Search Results
Results 201 - 250 of 1943
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Thurstan Sarah A - - 2012
Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and ...
Sivka Urška - - 2012
Despite being genetically very closely related, the marble trout Salmo marmoratus and the brown trout Salmo trutta exhibit marked phenotypic differences, particularly with regard to skin pigmentation. Histological analysis of skin from the head and gill cover of differently aged individuals of the two species was carried out in order ...
Goodman Greg J - - 2012
A software program called "HOYS" has been developed to depict various aspects and degrees of aging at 35 constituent subregions of seven distinct facial or exposed extrafacial regions. This program is underpinned by five-point photonumeric Likert scales characterizing skin surface and volume changes across five decades for each of the ...
den Engelsen Corine - - 2012
Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central ...
Velarde Michael C - - 2012
Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive oxygen species (ROS) have been shown to cause cellular senescence in culture, and accumulated molecular damage due to ...
Passtoors Willemijn M - - 2012
The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for mRNAs whose ...
Firooz Alireza - - 2012
Understanding the physiological, chemical, and biophysical characteristics of the skin helps us to arrange a proper approach to the management of skin diseases. The aim of this study was to measure 6 biophysical characteristics of normal skin (sebum content, hydration, transepidermal water loss (TEWL), erythema index, melanin index, and elasticity) ...
Peeters Maarten W - - 2012
The aim of the study was to evaluate whether subject positioning would affect the measurement of raw body volume, thoracic gas volume, corrected body volume and the resulting percent body fat as assessed by air displacement plethysmography (ADP). Twenty-five young adult men (20.7±1.1 y, BMI = 22.5±1.4 kg/m(2)) were measured using the ...
Schade Daynika J - - 2012
Early body condition may be important for adult behavior and fitness, and is impacted by a number of environmental conditions and biotic interactions. Reduced fecundity of adult females exposed to larval competition may be caused by reduced body condition or shifts in relative body composition, yet these mechanisms have not ...
Abattouy N - - 2012
To investigate sensitization to third-stage Anisakis simplex larvae in a randomly selected population in northern Morocco. We studied sera obtained from clinical analysis laboratories in Tangier and Tetuouan and from fishermen at Tangier port. The age of the study population ranged from 6 to 83 years. ImmunoCAP and immunoblotting techniques ...
Mills Melissa B MB Department of Genetics, Stanford University School of Medicine/Lucile Packard Children's Hospital, 300 Pasteur Drive, Boswell Building A097, Stanford, CA 94304, USA. - - 2012
Autosomal dominant conditions are known to be associated with advanced paternal age, and it has been suggested that retinoblastoma (Rb) also exhibits a paternal age effect due to the paternal origin of most new germline RB1 mutations. To further our understanding of the association of parental age and risk of ...
Ghazaryan Ara A - - 2011
BACKGROUND: Tissue glycation, the main cause of many diabetes-related complications, results in the accumulation of advanced glycation endproducts (AGE). OBJECTIVES: These AGEs are endogenous fluorophores that can serve as a viable pathological indicator for disease diagnostics. Here we explore the capabilities of multiphoton microscopy to non-invasively localize and quantify the ...
Puleo Connor Morrow - - 2011
De novo events appear more common in female and simplex autism spectrum disorder (ASD) cases and may underlie greater ASD risk in older fathers' offspring. This study examined whether advancing paternal age predicts an increase in simplex (n = 90) versus multiplex ASD cases (n = 587) in 677 participants ...
Veiga-Junior Nélio Neves - - 2012
The aim of this study was to search for clinical and laboratorial data in 46,XY patients with ambiguous genitalia (AG) and normal testosterone (T) synthesis that could help to distinguish partial androgen insensitivity syndrome (PAIS) from 5α-reductase type 2 deficiency (5α-RD2) and from cases without molecular defects in the AR ...
Kakasheva-Mazhenkovska L - - 2011
(Full text is available at http://www.manu.edu.mk/prilozi). The aim of this paper was to create a reference model for the qualitative and quantitative characteristics of healthy human skin in different body regions and different life periods. For this purpose we have taken skin biopsy specimens from 15 different body regions: capillitium, ...
Kakasheva-Mazhenkovska L - - 2011
(Full text is available at http://www.manu.edu.mk/prilozi). The aim of this paper is to present the dynamics of changes in the structural components of the skin of the capillitium throughout the entire life by use of morphometric analysis. For this purpose skin biopsy specimens were collected from patients from Plastic and ...
Isa Noor Hayati Mohd - - 2011
Demodicosis is an infestation of the skin with Demodex, an ectoparasite commonly found on the face. A cross-sectional study was conducted to detect the presence of the ectoparasite and the outcome of facial cleanser and moisturizer usage on its infestation. Universal sampling was performed among 390 medical students, age 20-25 ...
Baresch Andres - - 2011
• Premise of the study: The fossil leaf Karatophyllum bromelioides L. D. Gómez found in Costa Rica was proposed by Gómez (1972) to belong to the Bromeliaceae and to date from the middle Tertiary. If the age and affinity of this specimen were proven to be correct, it would constitute ...
Kurzius-Spencer Margaret - - 2012
Familial aggregation of specific response to allergens and asthma adjusted for age and sensitization to multiple allergens was assessed in two large population cohorts. Allergen skin prick tests (SPTs) were administered to 1151 families in the Tucson Children's Respiratory Study (CRS) and 435 families in the Tucson Epidemiological Study of ...
Lohmann Ebba - - 2011
Abstract The prevalence and family structure of idiopathic Parkinson disease (iPD) in Turkey is not known. Patients with iPD were recruited consecutively at the Medical School of Istanbul University over an 18 month period. Clinical details were assessed with standardized forms. Of the 219 iPD patients, 136 had sporadic iPD ...
Hughes Ian P - - 2011
Objective:  To investigate response to growth hormone (GH) in the 1(st) , 2(nd) and 3(rd) years of treatment for all idiopathic GH deficient (GHD) and idiopathic short stature (ISS) patients in Australia. Context:  Eligibility for subsidised GH treatment in Australia is determined on auxological criteria for the indication of Short ...
Tomaszewski Paweł - - 2011
Since rock climbing grows in popularity, the number of the respective scientific reports increases. However, those concerning anthropometric profile of elite climbers are scarce and inconsistent, thus the aim of the study was to describe the anthropometric characteristics of competitive sport climbers. Male rock climbers (n = 21) aged 17 ...
Di Somma C - - 2011
Aging is associated with decay in the somatotroph axis, that has been considered to cause many of the catabolic sequelae of normal aging. The physiological changes that the human body undergoes during aging are similar to those observed in GH deficiency (GHD). Changes of aging are represented by increased fat ...
Platt Steven G - - 2012
The Siamese crocodile (Crocodylus siamensis) is considered one of the least studied and most critically endangered crocodilians in the world. Although few wild populations remain, more than 700,000 C. siamensis are held on commercial crocodile farms in Southeast Asia. Despite conservation concerns, many aspects of C. siamensis life history remain ...
Skytthe A - - 2011
In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger ...
Rossi L F - - 2011
The morphological and histological features of the unusual reproductive tract of the female lesser anteater, Tamandua tetradactyla (Myrmecophagidae, Xenarthra), are described for the first time. The present study aimed to establish the main similarities and differences between this species and other xenarthrans. The populations of this species are declining rapidly ...
Hiremath V K VK Department of Oral and Maxillofacial Pathology, Dean Mansarovar Dental College, Kolar Road, Bhopal India and Ex Faculty, School of Dental Sciences, University Sains - - 2011
The aims of this study were to determine the prevalence, size, shape, and location of torus palatinus (TP) and torus mandibularis (TM), and to assess their sex-related and age-related differences in the Malay population. Sixty-five subjects were assessed for the presence of both tori at the School of Dental Sciences ...
Chan Sarah S Institute for Science, Ethics and Innovation, University of Manchester, - - 2011
Animals, in the age of biotechnology, are the subjects of a myriad of scientific procedures, interventions, and modifications. They are created, altered, and experimented upon--often with highly beneficial outcomes for humans in terms of knowledge gained and applied, yet not without concern also for the effects upon the experimental subjects ...
Cvetkovska Emilija - - 2011
Idiopathic generalised epilepsies (IGE) constitute nearly one third of all epilepsies. IGEs manifest with absences, myoclonic jerks and generalised tonic-clonic seizures (GTCS), either alone or in varying combinations, and have a strong genetic background. We present two three-generation families with juvenile myoclonic epilepsy (JME) probands and other affected family members ...
Ducrocq Stéphane - - 2011
Recent excavations in northwestern Kenya have recovered a vertebrate fauna of late early or early late Oligocene age. Among the mammal remains, a fragmentary lower jaw and an isolated upper molar have been attributed to a small primate, Lokonepithecus manai gen. et sp. nov. Lokonepithecus is a primitive member of ...
Yu Junxiu - - 2011
An understanding of the clinical features of gastric cancer (GC) in hereditary diffuse gastric cancer (HDGC) families may be helpful in deciding who should receive prophylactic total gastrectomy and when. This study evaluates the sex ratio and age of onset features of these patients. Forty-seven HDGC families were screened from ...
Powell Lisa - - 2011
The history and pathophysiology of the Female Athletic Triad is discussed along with the short-term and long-term complications. The work-up for hormonal abnormalities and specific treatment options are discussed. Also, nutrition and its affect on the Female Athletic Triad is mentioned within the realm of treatment.
Smith Jordan Ned - - 2011
Age-dependent chlorpyrifos (CPF) metabolism was quantified by in vitro product formation in human hepatic microsomes (ages 13 d-75 y) and plasma (ages 3 d-43 y) with gas chromatography/mass spectrometry (GC/MS). Hepatic CPF cytochrome P450 (CYP) desulfuration (CPF to chlorpyrifos-oxon [CPF-oxon]) and dearylation (CPF to 3,5,6-trichloro-2-pyridinol [TCPy]) V(max) values were 0.35 ...
Itou Yoshie - - 2011
Adult hippocampal neurogenesis contributes to the hippocampal circuit's role in cognitive functioning. New neurons are generated from hippocampal neural stem cells (NSCs) throughout life, but their generation is substantially diminished in aged animals due to a decrease in NSC proliferation. Because acetylcholine (ACh) is an important neurotransmitter released in the ...
Leung Lawrence - - 2011
Mark, 54 years of age, has a nontender lump on his praecordium that has been present 'for a long time'. He vaguely recalls a smaller lump at the same site years ago, which he squeezed, with subsequent resolution. Mark denies any bleeding, however, he has noticed occasional yellowish-brown stains on ...
Wang T - - 2011
Many factors, such as nitric oxide synthase, androgen and growth factors, can regulate the tone of corpus cavernosum (CC) smooth muscle with an age-related tendency. It has been shown that the active metabolites of kallikreins-kinins system (KKS), including bradykinin, Lys-BK and Met-Lys-BK, can also relax the CC smooth muscle significantly ...
Ruggles Steven - - 2011
This study uses a new source of linked census data (N = 6,734) to test theories proposed to explain the high intergenerational coresidence in 19th-century America. Was it a system of support for dependent elderly, or did it reflect intergenerational interdependence? I focus on transitions from middle age to old ...
Wichard Wilfried - - 2011
Palerasnitsynus ohlhoffigen. et sp. n. is described fromBurmese amber of late Albian (Lower Cretaceous) age. This is the first record of the family Psychomyiidae from Burmese amber, and the earliest fossil record of the family. The genus Palerasnitsynusgen. n. differs from all other known psychomyiid genera by the absence of ...
Izquierdo Matías A - - 2011
Male genital mutilation is a common mechanism by which males reduce sperm competition by plugging female insemination ducts with different parts of its own genital system. This behavior is frequent in many spider families but is uncommon in Haplogynae. The reproductive biology of Dysderoidea is not well studied and the ...
Nagase Yoshikazu - - 2010
To analyze gender differences in cleft pattern by the clinical statistical study of Japanese patients with cleft lip and/or cleft palate. Cleft pattern modeling was used to analyze 782 patients with cleft lip and/or cleft palate (417 males and 365 females) who had been examined at the Cleft Lip and ...
Foy Michael R - - 2011
The ovarian steroid hormones estradiol and progesterone regulate a wide variety of non-reproductive functions in the central nervous system by interacting with molecular and cellular processes. A growing literature from studies using rodent models suggests that 17β-estradiol, the most potent of the biologically relevant estrogens, enhances synaptic transmission and the ...
Rodríguez-Sosa Leonardo - - 2011
In our study we investigated the influence of dopamine (DA) on the caudal photoreceptor (CPR) in crayfish. Here we report the following: (a) the chromatographic determination of DA in the sixth abdominal ganglion (6th AG) shows a variation in the content during a 24-h cycle with the maximum value at ...
Cordeiro Ana Lúcia - - 2010
Aging is the single most significant risk factor for erectile dysfunction (ED), leading to structural modification of cavernous tissue and altering expression of vascular growth factors. The angiopoietin/Tie2 system has been recently considered as a potential target for therapy of vascular disorders, including ED. Hence, the aim of this study ...
Shamolina T S - - 2010
The effects of immobilization (1 h/day) of female rats from days 15 to 18 of pregnancy on the secretion of sex steroid hormones depending on the stage of the estrous cycle, functional activity of the hypophyseal-adrenocortical system (HAS), and its sensitivity to regulatory signals were studied in their female offspring ...
Lee Choong Hyun - - 2011
Ribosomal protein S3 (rpS3) is well known to participate in DNA repair mechanisms. In the present study, we compared rpS3 immunoreactivity and its protein levels in the hippocampus among young, adult and aged gerbils. In the postnatal month (PM) 3 group as the young, rpS3 immunoreaction was observed in pyramidal ...
Taguchi Toru - - 2010
The change with age in pain perception in humans and the nociceptive behaviors in animals elicited by noxious stimuli to the skin are not well understood, and little is known about the peripheral neural mechanisms of cutaneous nociception in the aged. We systematically examined cutaneous nociceptor responses and nociceptive behaviors ...
Pétervári E - - 2011
Changes of the anorexigenic and hypermetabolic components of the overall catabolic effect of alpha-MSH were studied in rats as a function of age. In male Wistar rats a 7 day-long intracerebroventricular infusion of alpha-MSH suppressed food intake and caused a fall in body weight in 2 and 3-4 month-old (young) ...
Villar-Cheda Begoña - - 2012
An age-related proinflammatory, pro-oxidant state in the nigra may increase the vulnerability of dopaminergic neurons to additional damage. Angiotensin II, via type 1 (AT1) receptors, is one of the most important known inflammation and oxidative stress inducers. However, it is not known if there are age-related changes in the nigral ...
Shepherd Mark N - - 2012
Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined. Here, we show that ...
Moretti M - - 2011
Clinical findings reveal that middle-aged patients are more susceptible to suffer from psychiatric disorders than older ones. However, little is known about the emotional behavior of aging rodents. This study aimed to investigate behavioral alterations in male middle-aged Wistar rats in the open-field (OF) test (at illuminated and dimly light ...
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