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Results 151 - 200 of 1943
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Choi Jae Woo - - 2012
BACKGROUND: Various skin parameters including skin visco-elasticity and hydration level affect the formation of wrinkles. OBJECTIVE: The aim of this study was to investigate the comprehensive and objective relationship between age, skin visco-elasticity, hydration level, and the occurrence of wrinkles using bioengineering equipments for the first time. METHODS: A total ...
Osborne R - - 2012
The use of global gene expression profiling, also known as transcriptomics or genomics, provides a means to identify key pathways affected in ageing skin that can be improved with appropriate cosmetic compounds. Aspects of skin ageing that can be addressed include matrix production, barrier, lipid synthesis, antioxidant capacity and hyperpigmentation. ...
Marsella Rosanna - - 2012
Background -  Cutaneous impairment plays a crucial role in atopic dermatitis (AD). Transepidermal water loss (TEWL) measurement is an indirect assessment of skin barrier function and correlates with disease severity in humans. Skin impairment also exists in canine AD; however, concerns exist regarding variability and reliability of TEWL measurements in dogs. ...
Kircik Leon H - - 2012
Background: Although reliable prevalence data are not available, adult acne is thought to be somewhat common, and it is not unusual for patients to have acne as well as early signs of skin aging. A novel anti-acne/anti-aging formulation (Treatment A) has been developed for daily use by patients to address ...
Hughes Maria Celia MC Cancer and Populations Studies, Queensland Institute of Medical Research, Brisbane, Qld, Australia. - - 2012
Evidence suggests that skin surface microtopography is a valid measure of photoaging among young adults, but whether this applies to older adults is unknown. We investigated the association between degree of photoaging as measured by histological dermal elastosis and skin microtopography grades by decade of age from 40 to 89 ...
Ohshima Hiroshi - - 2012
BACKGROUND/AIM: The decrease of skin elasticity on the cheek is a major concern to woman. The Cutometer(®) has been widely used to evaluate skin elasticity and its change with aging. Cutometer parameters derived from one suction have been traditionally used to evaluate skin elasticity, and few reports describe the use ...
Kim Da-Hee - - 2012
In February 2010, dermatitis characterized by scale and self-trauma due to puritis was recognized in a group of 22 four-toed hedgehogs (Atelerix albiventris Wagner, 1841) from a local pet shop in Gwangju, Korea. Microscopic examinations of skin scraping samples showed numerous mites of all developmental stages. Morphologically, pedicels of adult ...
Angelova-Fischer I - - 2012
Background:  The barrier perturbation pattern and molecular markers of inflammation upon tandem repeated irritation in chronologically aged skin have not been previously studied. Objectives:  We aimed to investigate the barrier impairment kinetic and in vivo cytokine profile following sequential irritation with sodium lauryl sulphate (SLS) and undiluted toluene in aged ...
Hofmann Britt - - 2012
Advanced glycation end products (AGEs) seem to be involved in ageing as well as in the development of cardiovascular diseases. During ageing, AGEs accumulate in extracellular matrix proteins like collagen and contribute to vessel stiffness. Whether non-invasive measurement of AGE accumulation in the skin may reflect vessel function and vessel ...
Levakov Aleksandra - - 2012
Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients ...
Al-Mutairi Nawaf - - 2012
Background: The primary cause of skin cancers is exposure to ultraviolet (UV) radiation. And, for decades sun protection has been promoted in various public health education campaigns. Recently, however, vitamin D deficiency has been related to increased risk of skin cancers. And, skin being the primary site for the synthesis ...
Konda S - - 2012
Changes in the skin that occur in the elderly may put them at increased risk for altered percutaneous penetration from pharmacotherapy along with potential adverse effects. Skin factors that may have a role in age-related percutaneous penetration include blood flow, pH, skin thickness, hair and pore density, and the content ...
Schouest Jonathan M - - 2012
A three month, open-label, single center study was conducted to determine whether a uniquely derived serum containing barley bioengineered, human-like epidermal growth factor protein could improve visible signs of photodamage and aging in facial skin. Twenty-nine females, aged 39 to 75 years, with mild to severe, fine and course rhytids, ...
Ramos-E-Silva Marcia - - 2012
Skin, together with its appendages, forms an organ with several defensive roles; among them it acts as a barrier, which is one of its very important protective functions. There has been increased interest in studying the effects of age on these functions. There are different intensities and timing involved in ...
El-Aal Nagwa H Abd - - 2012
Identifying the molecular mechanisms of intrinsic aging is critical in developing modalities for reversal of cutaneous aging. The objective was to evaluate the expression of epidermal Fas, epidermal thickness, collagen, and elastic fibers degeneration in unexposed skin of aged individuals compared with young ones. Skin biopsies were taken from normal ...
Zouboulis C C - - 2012
Abstract Intrinsic skin aging represents the biological clock of the skin cells per se and reflects the reduction processes that are common in internal organs. The reduced secretion of the pituitary, adrenal glands, and the gonads contributes to characteristic aging-associated body and skin phenotypes as well as behavior patterns. Our ...
Elewa Rana Mohsen - - 2012
Abstract Background and Objective: Skin, being a mirror of the body, is a major target for aging research. Aging is a complex process that involves the decline of function or dysfunction of many systems. The corticotropin-releasing hormone (CRH) system is involved in skin inflammation. In addition, CRH has a suggested ...
Dallara Jean-Marie - - 2012
Hand rejuvenation aims to restore volume and produce smooth, elastic skin. A combined treatment has been proposed: Juvéderm Ultra® 3 for filling and smoothing the skin and Juvéderm® Hydrate to rehydrate and restore skin quality. Twenty physicians enrolled 99 subjects (i.e., 198 hands). At the first visit, hands were injected ...
Fink B - - 2012
Although there is evidence that perception of facial age, health and attractiveness is informed by shape characteristics as well as by visible skin condition, studies on the latter have focused almost exclusively on female skin. Recent research, however, suggests that a decrease in skin colour homogeneity leads to older, less ...
Bruning Rebecca S - - 2012
Local skin heating is used to assess microvascular function in clinical populations because NO is required for full expression of the response; however, controversy exists as to the precise NO synthase (NOS) isoform producing NO. Human aging is associated with attenuated cutaneous vasodilation but little is known about the middle ...
Fiedler M - - 2012
Background: Skin aging is a risk factor for a decubitus and biophysical skin properties could help to identify persons at risk. Whether such biophysical properties of aged human skin differ between areas is undetermined. Objective: To investigate whether viscoelasticity, hydration or friction differ between important areas for decubitus risk. Methods: ...
Lagarrigue Sophie Garrido - - 2012
Reflectance confocal microscopy (RCM) may help to quantify variations of skin pigmentation induced by different stimuli such as UV radiation or therapeutic intervention. The objective of our work was to identify RCM parameters able to quantify in vivo dermis papilla density and epidermis pigmentation potentially applicable in clinical studies. The ...
Ishitsuka Y - - 2012
Background.  Photoageing of skin is thought to be caused by protein denaturation, which can be induced by ultraviolet radiation. Previous studies have also reported that inflammation is related to protein denaturation; however, the influence of inflammation on skin ageing has not been explored in detail. Aim.  To investigate the possible ...
Marotta Francesco - - 2012
Abstract This study tested the activity of LD-1227, which contains a caviar-derived homogenate added with coenzyme Q(10) (CoQ(10))-selenium component (CaviarLieri(®), Lab-Dom, Switzerland), in aged human skin and its potential role on skin mitochondria function. Human dermal fibroblasts were obtained from healthy donors over 70 years old and treated with LD-1227 ...
Martins Camila Marinelli - - 2012
Domestic animals in urban areas may serve as reservoirs for parasitic zoonoses. The aim of this study was to monitor the parasitic status of household dogs in an urban area of Pinhais, in the metropolitan region of Curitiba, Paraná State, Brazil, after a one-year period. In May 2009, fecal samples, ...
Kimlin Michael G - - 2012
BACKGROUND: Ultraviolet radiation exposure during an individuals' lifetime is a known risk factor for the development of skin cancer. However, less evidence is available on assessing the relationship between lifetime sun exposure and skin damage and skin aging. OBJECTIVES: This study aims to assess the relationship between lifetime sun exposure ...
Schreml Stephan - - 2012
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo. Methods: Time domain dual lifetime referencing with luminescent sensor foils was used for pH(SS) measurements. pH(SS) was ...
Hoesly Fridolin J - - 2012
OBJECTIVE: To assess the safety of a novel microneedle device on facial skin of healthy individuals of all Fitzpatrick skin types. DESIGN: Subject- and live rater-blinded, sham-controlled, randomized trial. SETTING: University-based ambulatory dermatology service providing both primary and referral care. PARTICIPANTS: Healthy adults recruited from postings. Intervention  Device or sham ...
Bosschaart Nienke - - 2012
OBJECTIVE:Although transcutaneous bilirubinometers have existed for over 30 years, the clinical utility of the technique is limited to a screening method for hyperbilirubinemia, rather than a replacement for invasive blood sampling. In this study, we investigate the reason for this limited clinical value and address possibilities for improvement.METHODS:To obtain better ...
Wu Shulian - - 2012
The characteristics of skins in different aging processes were obtained by optical coherence tomography (OCT) single scattering model, and their optical parameters were analyzed quantitatively. Significant differences were found in epidermis thickness and attenuation coefficients in chronological aging skins and photonaging skins. These parameters can be served as indicators of ...
Elsner P - - 2012
The use of cosmetics and medical cosmetic procedures by men has been widely ignored in dermatological research in the past, but it is finding increasing attention. As men are changing their habits and increasingly tend to use cosmetic products, the dermatologist will be asked for expert advice regarding efficacy and ...
Puschmann Stefan - - 2012
Extracellular skin structures in human skin are impaired during intrinsic and extrinsic aging. Assessment of these dermal changes is conducted by subjective clinical evaluation and histological and molecular analysis. We aimed to develop a new parameter for the noninvasive quantitative determination of dermal skin alterations utilizing the high-resolution three-dimensional multiphoton ...
Humbert Philippe - - 2012
As time passes, wrinkles typically appear. These skin depressions that become deeper and deeper draw more and more coarser lines on almost all the visible parts of aging individual's skin. They are indeed the most obvious and maybe disliked signs of skin aging, and thus, preventing and treating them are ...
Periyasamy R - - 2012
BACKGROUND: Foot problems are common in older people and altered biomechanical parameters under the foot sole has been proposed as a key risk factor for foot lesions. Therefore the aim of this study was to investigate the age-related differences in the hardness of foot sole skin. METHODS: Twenty-six healthy volunteers ...
TomĨík Michal - - 2012
OBJECTIVES: Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and ...
Goto Masashi - - 2012
Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin anti-aging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging was caused by ...
Gebauer Vera - - 2012
The surface profile of human skin influences characteristically the distribution pattern of topically applied formulations and consequently the efficacy of sunscreens. The volumes of furrows and the spectroscopically determined factors of inhomogeneity are investigated for three sunscreens. A clear correlation between both measurands exists. The average values for younger (<32 ...
Di Lorenzo Gabriele - - 2012
Changes in rhinitis symptom severity tend to decrease with aging, but whether the decrease is associated with allergic skin test reactivity, serum total and specific IgE, and nasal eosinophils or determined only by aging is poorly understood. The aim of the study was to analyze sensitivity in vivo and in ...
Mair Sarah - - 2012
We studied the acceptability and feasibility of delivering sun protection messages via electronic media such as short message services (SMS) to people aged 18-40 years. An online survey was conducted using a pre-established panel of volunteers. We compared the characteristics of those who indicated that they would like to be ...
Zanna Giordana - - 2012
Objective-To determine whether high-frequency diagnostic ultrasonography is useful for assessment of skin thickness in Shar-Peis. Animals-10 healthy Shar-Peis and 10 healthy Beagles used as controls. Procedures-Ultrasonographic examination of the skin was performed on 4 cutaneous sites by use of a 13-MHz linear-array transducer, and the mean of 3 measurements was ...
Nyembue Tshipukane Dieudonné - - 2012
BACKGROUND: Allergic rhinitis (AR) is increasing worldwide, but little is known about AR in Africa. We aimed to establish the prevalence of AR and related allergic diseases, to classify AR according to the Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines, and to determine factors associated with allergy in ...
de Souza Lucena Ee - - 2012
Objectives:  Assess the prevalence and potential factors associated to actinic cheilitis (AC) in workers exposed to the sun. Materials and methods:  Workers assigned to urban beaches in a city in Northeastern Brazil completed a questionnaire containing personal and health data. Lips were examined to identify AC. Results:  A total of ...
Soska Vladimir - - 2012
Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls.Methods: 82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of ...
Spitale Robert C - - 2012
Cigarette smoking is well-known to associate with accelerated skin aging as well as cardiovascular disease and lung cancer, in large part due to oxidative stress. Because metabolites are downstream of genetic variation, as well as transcriptional changes and post-translational modifications of proteins, they are the most proximal reporters of disease ...
Kim Ji-Hoon - - 2012
Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including anti-inflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which ...
Rasul A - - 2012
This study was aimed to formulate and evaluate anti-aging effects of a topical cream (w/o emulsion) containig extract of Fennel (Foeniculum vulgare) versus its base. Formulation containing 4% concentrated extract of Foeniculum vulgare was developed by entrapping in the inner aqueous phase of w/o emulsion and base contained no extract. ...
Haag Markus - - 2012
Hormone concentrations decline with aging. Up to now it was not clear, whether the decrease of hormone concentrations in blood samples are also present in cutaneous suction blister fluids, and whether skin from different anatomical sites shows different hormone concentrations.Analysis of suction blister fluids and paired blood samples from young ...
Cheah Whye L - - 2012
Abstract This study examined the relationship between perceived built environment attributes and physical activity, physical fitness and body weight among adolescents aged 14-16 years in Sarawak. This was a cross-sectional study, using multi-stage sampling. A set of questionnaires consisting of socio-demographic information, a self-administered physical activity checklist and a Neighborhood ...
Morganti P - - 2012
Background: Nutritional and topical antioxidants and immuno-modulant compounds play a key role in maintaining healthy skin. However, little is known about the combined effects antioxidant cosmeceuticals and nutricosmetics can have on the appearance of aging skin. Objective: The clinical trial was designed to study the combined effects on skin hydration, ...
Winters Charlene A - - 2012
Describe respiratory health and quality of life in persons exposed to Libby amphibole asbestos (LAA) contaminated vermiculite. Cross-sectional descriptive. Asbestos-related disease clinic in Libby, Montana USA. 329 individuals exposed to LAA; mostly men, married, between 50 and 69 years; two-thirds lived in the surrounding county; one-third lived elsewhere in the ...
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