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Créac'h Christelle C Pain Center & Department of Neurology, CHU Saint-Etienne, 42055, Saint-Etienne, France; Central Integration of Pain Lab, INSERM U1028 &UMR 5292, Centre for Neuroscience of Lyon, - University Claude Bernard of Lyon & University Jean Monnet, 42023, Saint-Etienne, - - 2014
Introduction: Aging has been reported to reduce the amplitude of laser evoked potentials. However, it is unknown whether this effect depends on the length of the sensory fibers. This is an important issue, since most painful neuropathies are length-dependant. Methods: We conducted a study of 40 healthy subjects, half of ...
Abraham Solana S Laboratorio de Investigaciones Ecoetológicas de Moscas de la Fruta y sus Enemigos Naturales (LIEMEN), PROIMI, Tucumán, Argentina; CONICET, Argentina. Electronic address: - - 2014
In numerous insects, accessory gland products (AGPs) transferred from males to females during mating are responsible for female sexual inhibition, but these products can be affected by male condition. Here, we investigated the effect of AGPs on female receptivity of the Mexican fruit fly Anastrepha ludens (Loew), and the effect ...
Amitay-Rosen Tal T a Department of Physical Chemistry , Israel Institute for Biological Research , P.O.B. 19, Ness-Ziona 74100 , - - 2014
Abstract The effects of an eight-year natural aging of ASC impregnated activated carbon on the adsorption capacity and breakthrough times of model organic vapors and of the nerve agent sarin were investigated. Aging delayed methanol breakthrough from dry air on pre-dried carbon, but shortened the breakthrough time of both methanol ...
Esopenko Carrie C Baycrest Health Sciences, Rotman Research Institute, Toronto, Ontario, Canada ; - - 2014
Traumatic brain injury (TBI) is a highly prevalent condition with significant effects on cognition and behavior. While the acute and sub-acute effects of TBI recover over time, relatively little is known about the long-term effects of TBI in relation to neurodegenerative disease. This issue has recently garnered a great deal ...
Golem Devon L DL 1Department of Family and Consumer Science, New Mexico State University 2Department of Exercise Science and Sport Studies, Rutgers - - 2014
Improvements in muscular power and anaerobic performance have resulted from use of jaw-repositioning mouth guards designed with advanced dental techniques. The high cost of such techniques has dissuaded the widespread use. Recently, more affordable, over-the-counter (OTC) jaw-repositioning mouth guards have become available. The primary objective of this study was to ...
Vopat Bryan G - - 2014
Decades of research support the fact that much age-related deterioration is the result of the effects of sedentary lifestyles and the development of medical conditions rather than of aging itself. Elite older athletes, who demonstrate enhanced performance compared with historic cohorts and even some younger peers, are models of this ...
Köteles F F Eötvös Loránd University Institute for Health Promotion and Sport Sciences Bogdánfy Ödön u. 10 H-1117 Budapest - - 2014
Effects of inhaled essential oils (EOs) cannot be explained by pharmacological mechanisms alone. The study aimed to investigate the effects of pleasantness of and expectancies evoked by EOs. A double-blind experiment with a within-subject design was carried out with the participation of 33 volunteering adults (15.2% male; mean age 37.7 ...
Wattie Nick N Faculty of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON, L1H 7K4, Canada, - - 2014
The policies that dictate the participation structure of many youth sport systems involve the use of a set selection date (e.g. 31 December), which invariably produces relative age differences between those within the selection year (e.g. 1 January to 31 December). Those born early in the selection year (e.g. January) ...
Wade M M Department of Applied Psychology and Human Development,University of - - 2014
The effect of low birth weight on children's development has been documented for a range of neurocognitive outcomes. However, few previous studies have examined the effect of birth weight variability within the normal range on children's neuropsychological development. The current study examined birth weight variation amongst children weighing ≥2500 g ...
Ayoubi Farah - - 2014
To compare gait variability among older community-dwellers with and without fear of falling and history of falls, and 2) to examine the association between gait variability and fear of falling while taking into account the effect of potential confounders. Based on a cross-sectional design, 1,023 French community-dwellers (mean age +/- ...
Côté-Maurais Guillaume G Institut National de la Recherche Scientifique-Institut Armand-Frappier, 531 boul. Des Prairies, Laval, Québec, Canada H7V - - 2014
Immunotoxicity studies of nanoparticles on T cells addressed their effects on activation by T antigen receptor, but have neglected the regulation of proliferation by IL-2. In this study, the IL-2-dependent T lymphoblastoid WE17/10 cell line was used to compare silver (Ag-NPs) and fullerene (C60-NPs) nanoparticles' toxicity and evaluate whether these ...
Ebejer J L JL Environmental and Rural Sciences, University of New England, Armidale, NSW, Australia, - - 2014
The heritability of attention-deficit/hyperactivity disorder (ADHD) is higher for children than adults. This may be due to increasing importance of environment in symptom variation, measurement inaccuracy when two raters report behavior of a twin-pair, a contrast effect resulting from parental comparison of siblings and/or dimensionality of measures. We examine rater ...
Nascimento Bárbara Mazetti BM UFPR, Curitiba, Brazil, - - 2014
This study aimed to investigate the following environmental effects in Suffolk lambing: contemporary groups, type of birth, and age of animal and age of dam at lambing on conformation (C), precocity (P), musculature (M), and body weight at postweaning (W), and the heritability coefficients and genetic correlations among these traits. ...
Moore Patrick V PV Centre for Health Policy and Management, Trinity College Dublin, 3/4 Foster Place, College Green, Dublin 2, Ireland, - - 2014
Concerns about the long-term sustainability of health care expenditures (HCEs), particularly prescribing expenditures, has become an important policy issue in most developed countries. Previous studies suggest that proximity to death (PTD) has a significant effect on total HCEs, with its exclusion leading to an overestimation of likely growth. There are ...
Galbraith Sally S School of Mathematics and Statistics, The University of New South Wales, - - 2014
Longitudinal studies are often used to investigate age-related developmental change. Whereas a single cohort design takes a group of individuals at the same initial age and follows them over time, an accelerated longitudinal design takes multiple single cohorts, each one starting at a different age. The main advantage of an ...
Rathi Sre P R PR Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India. Electronic address: - - 2014
Simple, yet an effective and rapid approach for the green synthesis of silver nanoparticles (Ag NPs) using root extract of Erythrina indica and its in vitro antibacterial activity was tried against human pathogenic bacteria and its cytotoxic effect in breast and lung cancer cell lines has been demonstrated in this ...
Namjoshi Gajanan S GS MSD Pharmaceuticals Pvt Ltd, Mumbai, India. Electronic address: - - 2014
Burden of rotavirus gastroenteritis (RVGE) in outpatient setting in India is not fully understood. A prospective study was undertaken to describe RVGE among Indian children less than 5 years of age presenting in outpatient departments with acute gastroenteritis (AGE). This study was conducted at 11 outpatient departments (OPDs) of private ...
Banks Gareth G MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, - - 2014
The circadian system is entrained to the environmental light/dark cycle via retinal photoreceptors and regulates numerous aspects of physiology and behavior, including sleep. These processes are all key factors in healthy aging showing a gradual decline with age. Despite their importance, the exact mechanisms underlying this decline are yet to ...
Kawazu Kei - - 2014
The success of mating disruption using synthetic sex pheromones depends not only on preventing mating, but also on delayed mating in the target insect. Using the rice leaffolder moth, Cnaphalocrocis medinalis (Guenée), we determined the effect of increased age at mating imposed on males only (male treatment), females only (female ...
Zhang Bo B College of Plant Protection, Nanjing Agricultural University, Agricultural Pests Management Laboratory of Ministry of Education, Nanjing 210095, PR - - 2014
Abstract The domed fitness functions are suggested to describe developmental patterns of progeny parasitoids in relation to host age at oviposition in solitary koinobint parasitoids that are engaged in single parasitism, but few studies have investigated the applicability of the functions as related to superparasitism. The present study was designed ...
Zhang Fei-Fei FF School of Civil Engineering, Hefei University of Technology, Hefei 230009, - - 2014
Roxarsone (3-nitro-4-hydroxy benzene arsenic acid) is an organoarsenic feed additive and has been widely used in the poultry industry to prevent coccidiosis and improve feed efficiency. The presence of roxarsone and its degradation products results in the instability of the anaerobic methanogenic process. This study investigated the degradation and speciation ...
Waldmann Elisabeth E Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria, - - 2014
An endoscopists adenoma detection rate (ADR) of less than 20 % correlates with high risk for occurrence of interval cancer. The impact of high-definition (HD) imaging on the ADR is discussed controversially. We aimed to investigate whether detection rates of individual endoscopists increase within 1 year before and 1 year after the switch ...
Parmley Maria - - 2014
This study investigated how target sex, target age, and expressive ambiguity influence emotion perception. Undergraduate participants (N = 192) watched morphed video clips of eight child and eight adult facial expressions shifting from neutral to either sadness or anger. Participants were asked to stop the video clip when they first ...
Park Hyun-Joo HJ 1 Dongguk University, - - 2014
Summary.-The current study was an attempt to examine the interplay between domain-specific self-esteem and life satisfaction with middle-aged Koreans. For four domains (Social/Objective Ability, Positive Characteristics, Interpersonal Relationships, and Family), the mediating effects of the satisfaction index of domain-specific self-esteem between the importance index of domain-specific self-esteem and life satisfaction ...
Navascues-Cornago Maria M Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, United - - 2014
The aim of this study was to map the sensitivity of the marginal and other conjunctival regions and to investigate changes in the sensitivity of these regions when determined in the morning and evening. Thirty-five healthy, noncontact lens wearers (20 female, 15 male; age 27.7 ± 7.3 years) were enrolled. ...
Mesic Aner A Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and - - 2014
The cytokinesis-block micronucleus cytome (CBMN-Cyt) assay was developed as a system for evaluating DNA damage, cytostasis, and cytotoxicity. The aim of the present study was to estimate levels of micronuclei (MNi), nucleoplasmic bridges (NPBs), nuclear buds (NBUDs), cell death (apoptosis/necrosis), nuclear division index, and nuclear division cytotoxicity index values in ...
Waye Andrew - - 2014
A 5-day fathead minnow (FHM) spawning assay is used by industry to monitor pulp mill effluent quality, with some mill effluents capable of completely inhibiting spawning. The purpose of this report is to characterize the effect of an inhibitory effluent on egg and milt production in FHM. Eight tanks were ...
Tebruegge Marc M Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, UKDepartment of Paediatric Infectious Diseases & Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, UK Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK Department of Paediatrics, Faculty of Medicine, The University of Melbourne, Parkville, Australia - - 2014
Results from 3263 QuantiFERON-TB Gold-in-Tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively), than in adult patients (2.6%; chi-quare p<0.0001). A detailed analysis of indeterminate QFT-GIT results is presented.
Varnell Charles D CD Jr Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2 . 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When ...
Mr Pradeep P Senior Lecturer, Department of Oral Pathology & Microbiology, AME'S Dental College, Hospital and Research Institute , Raichur, Karnataka, India - - 2014
Oral cancer is one of the most debilitating diseases afflicting mankind. Consumption of tobacco in various forms constitutes one of the most important etiological factors in initiation of oral cancer. When the focus of today's research is to determine early genotoxic changes in human cells, micronucleus (MN) assay provides a ...
Hurtz Sona S Department of Neurology, University of California Los Angeles, Calif., - - 2014
Atrophy in both grey and white matter is found in normal aging. The prefrontal cortex and the frontal lobe white matter are thought to be the most affected regions. Our aim was to examine the effects of normal aging on cortical grey matter using a 3D quantitative cortical mapping method. ...
Shen Li-Ming - - 2014
Recently, the development of optical probes for the assay of thiols, e.g., cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), has been an active research area due to their biological significance. We have found that carbon dots (C-dots) exhibit direct reduction of Ag+ to elemental silver (Ag0) and the resulting Ag0 ...
Keith Scott Alexander SA Department of Pediatrics, University of Pittsburgh School of Medicine, 7129 Rangos Research Centre, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA - - 2014
A wealth of knowledge on the genetic mechanisms that govern aging has emerged from the study of mutants that exhibit enhanced longevity and exceptional resilience to adverse environmental conditions. In these studies, lifespan has been an excellent proxy for establishing the rate of aging, but it is not always correlated ...
Thomsen Lise L The Fertility Clinic, Viborg Hospital, Skive, - - 2014
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to ...
Davaasuren Anu A Department of Parasitology, National Center for Communicable Diseases, Ministry of Health, Ulaanbaatar 13374, Mongolia. ; Department of Parasitology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, - - 2014
Epidemiological situation of taeniasis in Mongolia was assessed based on mitochondrial DNA identification of the parasite species. Multiplex PCR was used on a total of 194 proglottid specimens of Taenia species and copro-PCR and loop-mediated isothermal amplification (LAMP) assays were utilized for detection of copro-DNA of 37 fecal samples from ...
Gautier Jean-Charles JC 1Sanofi R&D, Paris, - - 2014
Differences were examined between male and female Sprague-Dawley rats in basal levels of a wide range of urinary biomarkers, including 7 recently qualified biomarkers. The data were generated from urine samples collected on 3 occasions from untreated rats included in a study of the effect of gentamicin nephrotoxicity on urinary ...
Zhang Zheng - - 2014
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been proposed as an ideal autologous stem cell source for cell-based therapy for myocardial infarction (MI). However, decreased viability and impaired function of aged MSCs hampered the therapeutic efficacy of engrafted MSCs, and the underlying mechanisms remain unclarified. Here, we investigated the role ...
Polanowski Andrea M AM Australian Antarctic Division, 203 Channel Highway, Kingston, TAS, 7050, - - 2014
Age is a fundamental aspect of animal ecology, but is difficult to determine in many species. Humpback whales exemplify this as they have a lifespan comparable to humans, mature sexually as early as four years and have no reliable visual age indicators after their first year. Current methods for estimating ...
Bidlingmaier Martin M Endocrine Research Laboratories (M.Bid., M.Bie.), Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336 Munich, Germany; Metabolic Center (N.F., H.W.), Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany; Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH) (R.T.E., A.D.), Institute of Epidemiology II, Neuherberg, Germany; Department of Endocrinology, Diabetes, and Nutrition (J.S., A.F.H.P., A.M.A.), Charité-University Medicine Berlin, Berlin, Germany; Experimental and Clinical Research Center (J.S.), Charité-University Medicine Berlin and Max-Delbrück Centre Berlin-Buch, Berlin, Germany; Center for Cardiovascular Research (J.S., A.M.A.), Charité-University Medicine Berlin, Berlin, Germany; Children's Clinic Randers (O.D.W.), Randers, Denmark; Göteborg Pediatric Growth Research Center (J.R.), The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Center for Pediatric Research (A.K.), Hospital for Children and Adolescents, Department of Women's and Child Health, University of Leipzig, Leipzig, Germany; Klinische Abteilung und Labor für Endokrinologie und Stoffwechsel (B.O.-P.), Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Austria; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe-Grosshadern (C.H.), Klinikum der Universität München, Munich, Germany; Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, Aarhus, Denmark; and Department of Clinical Nutrition (A.F.H.P., A.M.A.), German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, - - 2014
Context: Measurement of IGF-1 is a cornerstone in diagnosis and monitoring of GH-related diseases, but considerable discrepancies exist between analytical methods. A recent consensus conference defined criteria for validation of IGF-1 assays and for establishment of normative data. Objectives: Our objectives were development and validation of a novel automated IGF-1 ...
Stump Donald G DG Developmental and Reproductive Toxicology, WIL Research Laboratories, LLC, Ashland, - - 2014
The male and female pubertal assays, which are included in the U.S. Environmental Protection Agency's (EPA) Endocrine Disruptor Screening Program (EDSP) Tier 1 battery, can detect endocrine-active compounds operating by various modes of action. This article uses the collective experience of three laboratories to provide information on pubertal assay conduct, ...
Peck George W GW Vector Control Department, Entomology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring,MD 20910, - - 2014
We tested an immunomarking system that used egg white as marker and enzyme-linked immunosorbent assay as a detection assay to characterize face fly (Musca autumnalis DeGeer) dispersal from cow pats in a pastured beef cattle operation. In microcage assays, adult flies acquired marker after contact with cow pats that were ...
Sisterson Mark S - - 2014
A method to improve an assay relating adult feeding to egg maturation by the glassy-winged sharpshooter (Hemiptera: Cicadellidae) was evaluated. The assay consisted on confining females to cowpea stems and quantifying feeding and egg maturation. Feeding was quantified by measuring excreta production. The number of eggs matured during the assay ...
Zhang Wei-Guang WG Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing, - - 2014
To investigate the relationship between telomere length in peripheral blood white cells and cardiovascular function in a healthy, aging Han Chinese population. In 2012, peripheral blood leukocytes were obtained from 139 healthy individuals in Beijing, China, and telomere restriction fragment (TRF) length was assayed using a digoxigenin-labeled hybridization probe in ...
Friedrich Nele N Metabolic Center (N.F., H.W.), Institute of Clinical Chemistry and Laboratory Medicine, and Department of Psychiatry and Psychotherapy (H.J.G.), University Medicine Greifswald, D-17475 Greifswald, Germany; Department of Psychiatry and Psychotherapy (H.J.G.), Helios Hospital Stralsund, D-18437 Stralsund, Germany; Children's Clinic Randers (O.D.W.), DK-8900 Randers, Denmark; Department of Endocrinology, Diabetes, and Nutrition (A.M.A., J.S., A.F.H.P.) and Center for Cardiovascular Research (A.M.A., J.S.), Charité-University Medicine Berlin, D-10117 Berlin, Germany; Department of Clinical Nutrition (A.M.A., A.F.H.P.), German Institute of Human Nutrition Potsdam-Rehbruecke, D-14558 Nuthetal, Germany; Helmholtz Zentrum Muenchen-German Research Center for Environmental Health (R.T.E., A.D.), Institute of Epidemiology II, D-85764 Neuherberg, Germany; Experimental and Clinical Research Center (J.S.), Charité-University Medicine Berlin and Max-Delbrück Centre Berlin-Buch, D-13125 Berlin, Germany; Göteborg Pediatric Growth Research Center (J.R., J.D.), The Sahlgrenska Academy at University of Gothenburg, SE-41685 Gothenburg, Sweden; Institut für Laboratoriumsmedizin (J.K.), Klinische Chemie, Molekulare Diagnostik, University of Leipzig, D-04103 Leipzig, Germany; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe-Großhadern (C.H.), Klinikum der Universität München, D-81377 Munich, Germany; Endocrine Research Laboratories (M.B., M.B.), Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, D-80336 Munich, Germany; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University, and Department of Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, DK-8000 C Aarhus, - - 2014
Measurement of IGF-binding protein-3 (IGFBP-3) can aid the diagnosis of GH-related diseases. Furthermore, epidemiological studies suggest that IGFBP-3 and the molar IGF-I to IGFBP-3 ratio are associated with clinical end points like cancer or cardiovascular disease. However, their clinical use is limited by the lack of validated reference intervals. The ...
Gore M Odette MO Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, - - 2014
To determine the 99(th) percentile upper reference limit for the highly sensitive cardiac troponin T assay (hs-cTnT) in three large independent cohorts. The presently recommended 14 ng/L cutpoint for the diagnosis of myocardial infarction using the hs-cTnT assay was derived from small studies of presumably healthy individuals, with relatively little ...
Wang Xinfeng X 1Shandong Provincial Chest Hospital, Lab Medicine , Jinan , - - 2014
This study was performed aiming to evaluate the sensitivity of T-SPOT.TB assay in diagnosis of pediatric TB and investigate the association between age and results of T-SPOT.TB assay. Between March 2012 and September 2013, 102 patients, who aged ≤15 years old, were enrolled in this retrospective study and then were grouped ...
Wang Yuling Y Faculty of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitaetsstr. 5, D-45141 Essen, Germany. - - 2014
Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.
Aldrete Alfonso N García AN Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, Apartado Postal 70-153, 04510 México, D. F. MÉXICO.; Email: - - 2014
Acantholachesilla saltoensis gen. et sp. n. is described from Valle del Cauca, Colombia, in the Lachesillidae, tribe Graphocaeciliini (Eolachesillinae). The genus is related to Dagualachesilla and Dagualachesilloides that occur in the same area, differing from them in the male clunial projection, phallosome, and female subgenital plate and gonapophyses.
Hong Mei-Lan ML State Key Laboratory of Chemo/Bio-sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan - - 2014
A label-free fluorescent assay for the detection of trypsin by using oligonucleotide-templated silver nanoclusters (Ag NCs) and cytochrome c (Cyt c) has been demonstrated. When negatively charged Ag NCs and positively charged Cyt c are mixed, they tend to form a hybrid complex, and then lead the fluorescence of Ag ...
Friedland-Leuner Kristina K Molecular and Clinical Pharmacy, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, - - 2014
The etiology of common, nonfamiliar late-onset Alzheimer's disease (LOAD) is only partly understood and seems to be extremely complex including many genetic and environmental factors. The most important environmental risk factor to develop LOAD is aging itself. Aging and LOAD are considered to be strongly linked to mitochondrial dysfunction and ...
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