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Lin Chi Hua Sarah CH New York Medical - - 2014
A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful anti-angiogenic peptide, endostatin, represents one of the potent systemic causes for multi-organ microvascular rarefaction and ...
Nishino Jo J Center for Information Biology, National Institute of Genetics, Mishima, - - 2014
Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon-α, and ribavirin (PEG-IFN-α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment (P = 7.31 × 10(-8) ). The model incorporating genotype of the ...
Gharibi Borzo B Dept of Periodontology, Dental Institute, King's College London, Tower Wing, Guy's Hospital, London, SE1 9RT, - - 2014
The decline in mesenchymal stem cell (MSC) self-renewal and function with aging contributes to diseases associated with impaired osteogenesis. MSC donor age in prolonged culture also limits the therapeutic potential of these cells for tissue engineering and regenerative medicine. Here we demonstrate an intervention to preserve the immature state MSC ...
Baravalle Günther G Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA - - 2014
Dendritic cells (DCs) play an important role in immune homeostasis through their ability to present Ags at steady state and mediate T cell tolerance. This characteristic renders DCs an attractive therapeutic target for the induction of tolerance against auto-antigens or allergens. Accordingly, Ag-conjugated DC-specific Abs have been proposed to be ...
Knuppertz Laura L Institute of Molecular Biosciences and Cluster of Excellence Frankfurt Macromolecular Complexes; Department of Biosciences; J W Goethe University; Frankfurt, - - 2014
The filamentous ascomycete Podospora anserina is a well-established aging model in which a variety of different pathways, including those involved in the control of respiration, ROS generation and scavenging, DNA maintenance, proteostasis, mitochondrial dynamics, and programmed cell death have previously been demonstrated to affect aging and life span. Here we ...
Li Hongliang H Heart Rhythm Institute, Department of Medicine, University of Oklahoma Health Sciences Center and Veterans Affairs Medical Center, Oklahoma City, OK 73104, - - 2014
It is well established that atrial fibrillation (AF) is far more common in elderly humans. Autonomic activation is thought to be an operative mechanism for AF propensity. The aim of the study was to investigate the impact of age on atrial tachyarrhythmia induction in a rabbit model. Six old (aged ...
Shi Cheng C Lewis-Sigler Institute for Integrative Genomics and Dept. of Molecular Biology, Princeton University, Princeton, NJ 08544, - - 2013
Interactions between the germline and the soma help optimize reproductive success. We discovered a new phenomenon linking reproductive status to longevity: in both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing post-reproductive lifespan. Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibility, and subsequent lifespan ...
Jouhanneau Mélanie M Laboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, Nouzilly, - - 2013
Testosterone-dependent olfactory signals emitted by male are well known to accelerate female puberty in mice (Vandenbergh effect). However, it remains unclear whether these chemosignals also influence adult expression of male-directed odor preference. Therefore, we exposed female mice to intact or castrated male bedding (vs clean bedding as control) during the ...
Reece A S AS School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, - - 2013
Despite intriguing initial and associational studies, there remains little research on opiate-related arterial dysfunction and no longitudinal studies. As opiates act potently via P16INK4A/CDKN2A identified on GWAS screens, and as arterial ageing is a surrogate for organismal ageing, this area is of general concern. Thirty-eight male controls compared with 198 ...
Sorrentino Jessica A - - 2014
While murine-based systems to identify cancer-promoting agents (carcinogens) are established, models to identify compounds that promote aging (gerontogens) have not been described. For this purpose, we exploited the transcription of p16INK4a, which rises dynamically with aging and correlates with age-associated disease. Activation of p16INK4a was visualized in vivo using a ...
Miller Justine D - - 2013
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it to the modeling of Parkinson's disease ...
Umadevi Subramanian - - 2013
Advanced glycation en d products (AGEs) play a major role in the development of cardiovascular disorders in diabetic patients. Recent studies evidenced the beneficial role of phytochemicals in reducing the risk of cardiovascular diseases. Hence the present study was framed to investigate the protective role of Gallic acid (GA) on ...
Boyle Andrew J - - 2013
Aging is associated with higher incidence of heart failure and death following myocardial infarction (MI). The molecular and cellular changes that lead to these worse outcomes are not known. Young and aging mice underwent induction of MI by LAD ligation. There was a significant increase in mortality in the aging ...
Azim Hatem A HA Jr Jose Baselga, Memorial Sloan-Kettering Cancer Center, NY; James G. Greger Jr, GlaxoSmithKline, Collegeville, PA; Hatem A. Azim Jr, Martine Piccart, Evandro de Azambuja, BrEAST Data Centre, Institut Jules Bordet, Université Libre de Bruxelles; Phuong Dinh, Breast International Group, Brussels; Peter Vuylsteke, Sint-Elisabeth Hospital, Namur, Belgium; Dominique Agbor-tarh, Ian Bradbury, Frontier Science, Kincraig, Kingussie, Scotland; Ian Smith, Royal Marsden Hospital, and Institute of Cancer Research, London, United Kingdom; Serena Di Cosimo, IRCCS Fondazione Instituto Nazionale dei Tumori, Milan, Italy; Serena Di Cosimo, SOLTI Breast Cancer Research Group, Barcelona, Spain; Christian Jackisch, Kilinikum Offenbach, Offenbach; Bahriye Aktas, Kliniken Essen-Mitte, Evang, Essen; Holger Eidtmann, University Hospital Kiel, Kiel, Germany; Sung-Bae Kim, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Chiun-Sheng Huang, National Taiwan University Hospital; Ruey Kuen Hsieh, Mackey Memorial Hospital, Taipei, Taiwan; and Lydia Dreosti, University of Pretoria, Pretoria, South - - 2013
We investigated the pattern of rash, diarrhea, and hepatic adverse events (AEs) secondary to lapatinib and their association with age and pathologic complete response (pCR) in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALLTO) phase III trial. Patients with HER2-positive early breast cancer were randomly assigned to receive lapatinib (Arm ...
Yamasaki Kei - - 2013
The incidence of bepridil-induced pulmonary toxicity, such as interstitial pneumonia, is still unknown. The aim of the present study was to evaluate the incidence of bepridil-induced pulmonary toxicity. A total of 253 patients treated with bepridil between January 2009 and January 2011 were retrospectively evaluated. Eight out of the 222 ...
Gilbert John J JJ Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA. - - 2013
Brachionus calyciflorus typically develops long, defensive spines only in response to a kairomone from the predatory rotifer, Asplanchna. However, in the absence of any environmental induction, females of some clones produce daughters with increasingly long spines as they age; late-born individuals can have posterolateral spines as long as those induced ...
Chaplin Jay W JW Department of Immunology and 2 Molecular and Cellular Biology Program, University of Washington, Seattle, WA - - 2013
Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic cells (DCs), and then the Ag-anti-receptor is inoculated with an adjuvant. Here we report that targeting Ag to a receptor expressed on both B ...
Ismail Ahmad Filza - - 2013
Noise is known to be one of the environmental and occupational hazards listed in the Factory and Machinery Act 1967. Quarries with loud deafening sounds from trucks and machineries pose the risk of noise-induced hearing loss to workers. This study was designed to assess the knowledge, attitude and practice towards ...
Stapanian Martin A - - 2013
Concentrations of 86 congeners of polychlorinated biphenyls (PCBs) were determined for 25 adult female and 25 adult male burbot (Lota lota) from Lake Erie. Significant differences in mean proportions of total PCB concentration between males and females ages 14-17 were found for 26 congeners. Males generally had higher mean proportions ...
Hoyer Carolin - - 2013
Although preconceptional and periconceptional maternal stress is a recognized risk factor for offspring neurodevelopmental disturbances, less is known about the relevance of paternal exposures. These have hitherto been investigated mainly with respect to substance-induced impairment in the progeny. In recent years, experiential influences on offspring have come into focus through ...
Niu B - - 2013
/st>We determined the minimal alveolar concentration (MAC) of sevoflurane inducing an isoelectric EEG in 50% of adult subjects (MACie). /st>We included 31 middle-aged subjects; 30 subjects finished the study protocol and received sevoflurane at preselected concentrations according to a modified Dixon 'up-and-down' design starting at 1.7 vol% with 0.2 vol% ...
Adachi Yushi U - - 2013
The required dose of anesthetics is generally smaller in patients with low cardiac output (CO). A high CO decreases the blood concentration of anesthetics during induction and maintenance of anesthesia. However, a high CO may also shorten the delivery time of anesthetics to the effect site, e.g. the brain. We ...
Huang L - - 2013
/st>The ultrasound cardiac output monitor (USCOM) is a continuous wave Doppler system designed to measure cardiac output (CO) non-invasively and intermittently either from the pulmonary or from the aortic valve. USCOM scan quality is critical to obtaining reliable data and during anaesthesia it is said to deteriorate with increasing age. ...
Stanhewicz Anna E - - 2013
Reflex vasoconstriction is attenuated in aged skin due to a functional loss of adrenergic vasoconstriction. Bioavailability of tetrahydrobiopterin (BH4), an essential cofactor for catecholamine synthesis, is reduced with aging. Locally-administered BH4 increases vasoconstriction through adrenergic mechanisms in aged human skin. We hypothesized that oral sapropterin (Kuvan®, pharmaceutical BH4) would augment ...
Takeda Naoko - - 2013
Aging is a dominant risk factor for end-stage renal disease. We analyzed the mechanism involved in age-related exacerbation of proteinuria-induced proximal tubular cell (PTC) damage by focusing on endoplasmic reticulum-related unfolded protein response (UPR). After equal-degree induction of proteinuria in 24-month-old (aged) and 3-month-old (young) mice by intraperitoneal free fatty ...
Sharma Shilpa - - 2013
Herein, a green method for the development of a novel biodegradable silver nanoparticles (NPs) impregnated alginate-chitosan-blended nanocarrier (Ag NPs-Alg-Chi NC) is reported. The synthesis of Ag NPs-Alg-Chi NC is based on the polyelectrolyte complex formation between alginate and chitosan. The composite NC is characterized by ultraviolet-visible spectroscopy, transmission electron microscopy, ...
Chang Po-Chun - - 2013
Aim: Advanced glycation end products (AGE) have been found in inflamed gingival tissue and shown to interfere with the integrity of extracellular matrix and cell-matrix interactions. This study aimed to investigate the modulatory effect of aminguanidine (AG), an AGE inhibitor, in various stages of experimental periodontitis. Materials and Methods: Thirty-six ...
Nelms Brittany M BM Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, - - 2013
At temperate latitudes, Culex (Diptera: Culicidae) mosquitoes typically overwinter as adult females in reproductive arrest and also may serve as reservoir hosts for arboviruses when cold temperatures arrest viral replication. To evaluate their role in the persistence of West Nile virus (WNV) in the Sacramento Valley of California, the induction ...
Nabhan Zeina - - 2013
Objective: To characterize hormone replacement therapy in a cohort of adolescent boys and girls with hypogonadotropic hypogonadism (HH) with a focus on changes in management during the past 10 years.Methods: Medical records of patients followed for HH during the past 10 years were reviewed.Results: A total of 45 patients (22 ...
Robinson Mark W - - 2013
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated ...
Roulin Anne C - - 2013
Dormancy is a common adaptation in invertebrates to survive harsh conditions. Triggered by environmental cues, populations produce resting eggs that allow them to survive temporally unsuitable conditions. Daphnia magna is a crustacean that reproduces by cyclical parthenogenesis, alternating between the production of asexual offspring and the sexual reproduction of diapausing ...
Okazaki Ryuji - - 2013
We previously reported that in p53(+ / -) mice that had been given a whole-body dose of 3 Gy at 8 weeks of age, p53-dependent delayed effects of radiation, as manifested in T-cell receptor (TCR) variant fractions (VF) instability in mouse splenocytes, were biphasic, namely, induction of TCR-VF mutation reappeared ...
Martirosyan Alina - - 2013
Abstract The increasing commercial use of silver nanoparticles (Ag-NPs) will inevitably lead to elevated silver exposure and thus to potential human health complications. In this study the acute toxicity of Ag-NPs < 20 nm alone and upon co-administration with food matrix component phenolic compounds (PCs) on the cell-based models of ...
Yorifuji Takashi - - 2013
Yusho disease, a polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF) mixed poisoning caused by contaminated rice oil, occurred in Japan in 1968. The evidence on reproductive outcome is limited. We therefore evaluated the regional impact of the exposure to the PCB and PCDF mixture on stillbirth rate and secondary sex ...
Coleman Jessica G - - 2013
As the production and applications of nano silver (nano Ag) increase, it is essential to characterize fate and effects in environmental systems. Nano Ag materials may settle from suspension, therefore, our objective was to utilize environmentally relevant bioassays and study the impact, bioaccumulation, tissue distribution, uptake and depuration of nano ...
Portillo W - - 2013
Non-copulating (NC) males are those animals that do not mate in spite of repeated testing with sexually receptive females. They have been observed in several species including rats and mice. The present experiment was designed to perform a detailed behavioral characterization of NC male mice. Thus, we evaluated their sexual ...
Bisson Jean-François - - 2013
The TLC-Ag dressings, a combination of technology lipido-colloid and silver salts, are used to promote healing in wounds with risks or signs of local infection, thanks to the antimicrobial properties of the silver salts. Nanocrystalline silver dressings containing nanocrystalline silver, also used to improve wound healing, present both antimicrobial and ...
Mangge Harald - - 2013
Objective: Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan-kynurenine pathway. The study aimed to assess whether this holds true across the lifespan from juvenility to adulthood. Design and Methods: We analyzed 527 participants aged between 10 and 65 years. ...
Veres Monika - - 2013
Epilepsy is a debilitating disease characterized by recurring seizures. Epilepsy can be studied using animal models, such as rodents prone to audiogenic seizure (AGS), which experience generalized seizures (loss of consciousness accompanied by rhythmic muscle spasms and rigid muscle stiffness) after intense sound stimulation. In 1933, a spontaneous mutation resulting ...
Kubota Akira - - 2013
This study focuses on gender-specific accumulation features of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in common (great) cormorants (Phalacrocorax carbo) collected from Lake Biwa, Japan. Male cormorants showed a tendency to have higher levels of PCDD/DFs and DL-PCBs than did females. For PCDDs, the male-to-female concentration ...
Korhonen Niina - - 2013
BACKGROUND: Fall-related injuries and deaths of elderly people are a major public health concern. METHODS: Using the Official Cause-of-Death Statistics of Finland we determined the current trends in the number and age-adjusted incidence (per 100,000 persons) of fall-induced deaths among older Finnish men and women by taking into account all ...
Gangoiti María Virginia - - 2013
Advanced glycation endproducts (AGEs) accumulate with age in various tissues, and are further increased in patients with Diabetes mellitus, in which they are believed to contribute to the development and progression of chronic complications that include a decrease in bone quality. Bisphosphonates are anti-osteoporotic drugs that have been used for ...
Vitale Giovanni - - 2013
Ageing is a process characterized by a progressive decline in cellular function, organismal fitness and increased risk of age-related diseases and death. Several hundred theories have attempted to explain this phenomenon. One of the most popular is the 'oxidative stress theory', originally termed the 'free radical theory'. The endocrine system ...
Brembilla-Perrot Béatrice - - 2013
BACKGROUND: Syncope in Wolff-Parkinson-White syndrome (WPW) is without relationship with WPW or reveals a poorly tolerated arrhythmia. Electrophysiologic study (EPS) is recommended. The purpose of the study was to evaluate the influence of the patient's age on the causes and prognosis of syncope. METHODS: A total of 98 patients, mean ...
Ito Katsura - - 2013
In Tetranychus spider mites (Acari: Tetranychidae), diapausing females have a conspicuous orange body colour, which is used as an indicator of diapause induction in many laboratory studies. However, to which extent body colour reflects reproductive activity is scarcely investigated. In this study, we investigated the relationship between body colour, reproductive ...
Derayat Amid - - 2013
Induction of triploidy has been suggested as an effective tool to prevent spawning of farmed fish. This experiment examined the growth potential of triploid cod when reared communally with diploid ones after the juvenile stage. Pressure treatment was used to induce triploidy in a batch of cod eggs in April ...
Williams Alison Leah - - 2013
The study investigated men's experiences of taking part in an age-appearance-focussed intervention which involved seeing how their faces would age with and without UV exposure. Thirty-five men gave accounts of their experiences whilst taking part in the intervention, and eight men discussed their experiences retrospectively in focus groups. Transcripts were ...
Yamabe Soichiro - - 2013
Mammalian cells attempt to maintain their homeostasis under endoplasmic reticulum (ER) stress. If the stress cannot be alleviated, cells are led to apoptosis through C/EBP homologous protein (CHOP) induction. ER stress is provoked in osteoarthritis (OA) chondrocytes, and intracellular accumulation of advanced glycation end products (AGEs) in chondrocytes is a ...
Martin Geoffrey V - - 2013
AimThe aim of this article is to determine if lightning is associated with the frequency of headache in migraineurs.MethodsParticipants fulfilling diagnostic criteria for International Headache Society-defined migraine were recruited from sites located in Ohio (n = 23) and Missouri (n = 67). They recorded headache activity in a daily diary for three to six ...
Imasawa Toshiyuki - - 2013
Low birth weight (LBW) is thought to be one of the risk factors for the progression of kidney diseases. This study hypothesized that the onset age of kidney disease, the rate of progression of kidney disease, or the age at the time of hemodialysis (HD) induction among HD patients that ...
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