Search Results
Results 1 - 50 of 1072
1 2 3 4 5 6 7 8 9 10 >
Fesseau Roselyne R Department of Anesthesiology and Intensive Care, EA 4564 MATN, IFR 150, Pediatric Unit, University Public Hospital, Toulouse, - - 2014
There have been recent changes with regard to tools and concepts for respiratory management of children undergoing general anesthesia. To determine the practice of pediatric anesthetists concerning: preoxygenation, breathing systems, ventilation modes, anesthetic agent and airway device, strategies for a general anaesthetic of less than 30 min using spontaneous respiration, ...
Song Shige S Queens College & CUNY Institute for Demographic Research, The City University of New York, 65-30 Kissena Blvd., Queens, NY, 11367, USA, - - 2014
This study tests the evolutionary hypothesis that maternal nutritional condition can influence offspring sex ratio at birth in humans. Using the 1959-1961 Chinese Great Leap Forward famine as a natural experiment, this study combines two large-scale national data sources and difference-in-differences method to identify the effect of famine-induced acute malnutrition ...
Nam Sung Min SM Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South - - 2014
In this study, we compared N-methyl-D-aspartate receptor type 1 (NMDAR1) and 4-hydroxynonenal (4-HNE) in the hippocampus of D-galactose (D-gal)-induced and naturally aging models of mice. These markers represent general phenotypes in aging, and they allowed us to examine the possibility of D-gal as a chemical model agent for aging. We ...
Dismore Lorelle L Teesside University, - - 2014
Social constructions of men towards the availability of a male hormonal contraceptive, the 'male pill', were explored. A qualitative approach applying semi-structured interviews and scenarios with 22 men (mean age 35 years) from the North East of England revealed two core constructs and six sub-constructs using a Thematic-Construct Analysis in line ...
Kim S Y SY Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of - - 2014
Female sex and age more than 65 years are common risk factors for the development of torsades de pointes in association with heart rate-corrected QT (QTc) interval prolongation, which can be induced by tracheal intubation during general anaesthesia. However, the administration of remifentanil can prevent intubation-induced QTc interval prolongation. We compared ...
Kim Mi-Yeong MY Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan 614-735, Korea. ; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, - - 2014
Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults. The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults. A total of 208 healthy nonasthmatic adults ...
Kato Motohiro M Department of Pediatrics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, - - 2014
There is no standard treatment for adolescents aged 15 years or older with acute lymphoblastic leukemia (ALL), although this age group has been reported as having a poorer prognosis compared to younger patients. We retrospectively analyzed the outcomes of three consecutive Tokyo Children's Cancer Study Group ALL trials (1995-2006) of 373 ...
Drummond Murray M Flinders University, Australia - - 2014
This is an article about boys and their construction of masculinities. It draws on 5 years of qualitative research data from the same group of boys from early childhood through to 10 years of age in an attempt to articulate the way in which boys come to view their bodies, ...
Hoonhorst Susan J M SJ University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, GRIAC research institute, Groningen, the - - 2014
Cigarette smoking is the main cause of chronic obstructive pulmonary disease (COPD) inducing oxidative stress and local tissue injury, resulting in pulmonary inflammation. Advanced glycation end products (AGEs) are produced by glycation and oxidation processes and their formation is accelerated in inflammatory conditions. In this study we assessed whether AGE ...
Smulders Stijn S Center for Environment and Health, KU Leuven, Leuven, Belgium - - 2014
The unique physical and chemical properties of nanomaterials have led to their increased use in many industrial applications, including as a paint additive. For example, titanium dioxide (TiO2) engineered nanoparticles (ENPs) have well-established anti-UV, self-cleaning and air purification effects. Silver (Ag) ENPs are renowned for their anti-microbial capabilities and silicon ...
Tamura Naoaki N Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, - - 2014
Amniotic fluid embolism (AFE) is a rare, high-risk obstetric complication primarily found in the lungs and potentially related to anaphylaxis. Tryptase release from the mast cell reflects anaphylaxis. Case report and findings: A female, aged over 40 years, presented with uterine atony and lethal hemorrhage after induced vaginal labor. Cervical ...
Osterman Michelle Jk - - 2014
Data from the Natality Data File, National Vital Statistics System After nearly 20 years of consecutive increases, induction of labor for singleton births reached a high of 23.8% in 2010, then declined in 2011 (23.7%) and 2012 (23.3%). Trends in induction rates vary by gestational age, with rates for most ...
Nogueira Jordana de Almeida Jde A Departamento de Enfermagem Clínica, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, - - 2014
to analyze the sociodemographic characteristics, epidemic trend and spatial distribution of the risk of AIDS in adults 50 years of age and over. population-based, ecological study, that used secondary data from the Notifiable Disease Information System (Sinan/AIDS) of Paraíba state from the period January 2000 to December 2010. during the ...
Gould Christine E CE West Virginia University, Morgantown, West Virginia, - - 2014
ABSTRACT Background: Worry is experienced by many older adults, yet our understanding of the emotional experience of late-life worry is poor as findings regarding older adults are inferred from findings of studies conducted with young adults. In the present study, we aimed to characterize age differences in affect, self-reported arousal, ...
Agawa Tsuyoshi T *Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan; and †Department of Ophthalmology, National Defense Medical College, Saitama, - - 2014
To measure intraocular cytokine levels in patients with exudative age-related macular degeneration and analyze changes in the cytokine profile 2 days after intravitreal bevacizumab injection. This prospective case-control study enrolled 37 patients (37 eyes) with age-related macular degeneration including polypoidal choroidal vasculopathy. Twenty-eight age-matched patients (28 eyes) who underwent cataract ...
Leśniewicz Anna A Analytical Chemistry Division, Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland, - - 2014
The mineral composition of pathologically unchanged human fascia lata was examined here using inductively coupled plasma optical emission spectrometry (ICP-OES) method for the first time. The total concentrations of Ag, Al, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Mo, Ni, P, Pb, Sr, Ti, V and Zn ...
Mularz Amanda A University of California, Los Angeles, Los Angeles, - - 2014
Given increasing scrutiny on cesarean delivery rates and induction as a possible contributing factor, we sought to examine the association between maternal age and successful induction of labor in the context of gestational age and parity. Outcomes after induction of labor in term singleton pregnancies from 2006 to 2010 were ...
Quigley Charmian A CA Quigley: Indiana University School of Medicine, Indianapolis, IN, 46202.; Wan: Novartis Pharmaceuticals, E Hanover, NJ, 07936.; Garg: GCE Solutions Inc, Bloomington, IL, 61701.; Kowal: Thomas Jefferson University, Philadelphia, PA, 19107.; Cutler: Gordon Cutler Consultancy, LLC, Deltaville, VA, 23043.; Ross: Thomas Jefferson University, Philadelphia, PA, - - 2014
Context: The optimal approach to estrogen replacement in girls with Turner syndrome has not been determined. Objective: The aim of the study was to assess the effects of an individualized regimen of low-dose ethinyl estradiol (EE2) during childhood (CLDE) followed by a pubertal induction regimen staring after age 12 and ...
Heggebö Jostein J Department of Surgery, Experimental Surgery and Regenerative Medicine, University of Munich , - - 2014
Bone morphogenetic protein 2 (BMP-2) is a potent osteoinductive cytokine and a growing number of in vitro studies analyze its effects on human mesenchymal stem cells (hMSC) derived from aged or osteoporotic donors. In these studies the exact quantification of osteogenic differentiation capacity is of fundamental interest. Nevertheless, the experimental ...
Perry Rebecca J RJ University of Glasgow Department of Child Health, Royal Hospital for Sick Children, Glasgow, - - 2014
Background: A UK study showed final height in Turner syndrome (TS) girls receiving growth hormone is affected by age at pubertal induction and oxandrolone (Ox). Using data from that study, we analysed the effect of timing of oral ethinylestradiol (EE2) and Ox on height velocity (HV), bone maturation and pubertal ...
Lin Chi Hua Sarah CH New York Medical - - 2014
A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful anti-angiogenic peptide, endostatin, represents one of the potent systemic causes for multi-organ microvascular rarefaction and ...
Nishino Jo J Center for Information Biology, National Institute of Genetics, Mishima, - - 2014
Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon-α, and ribavirin (PEG-IFN-α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment (P = 7.31 × 10(-8) ). The model incorporating genotype of the ...
Gharibi Borzo B Dept of Periodontology, Dental Institute, King's College London, Tower Wing, Guy's Hospital, London, SE1 9RT, - - 2014
The decline in mesenchymal stem cell (MSC) self-renewal and function with aging contributes to diseases associated with impaired osteogenesis. MSC donor age in prolonged culture also limits the therapeutic potential of these cells for tissue engineering and regenerative medicine. Here we demonstrate an intervention to preserve the immature state MSC ...
Baravalle Günther G Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA - - 2014
Dendritic cells (DCs) play an important role in immune homeostasis through their ability to present Ags at steady state and mediate T cell tolerance. This characteristic renders DCs an attractive therapeutic target for the induction of tolerance against auto-antigens or allergens. Accordingly, Ag-conjugated DC-specific Abs have been proposed to be ...
Knuppertz Laura L Institute of Molecular Biosciences and Cluster of Excellence Frankfurt Macromolecular Complexes; Department of Biosciences; J W Goethe University; Frankfurt, - - 2014
The filamentous ascomycete Podospora anserina is a well-established aging model in which a variety of different pathways, including those involved in the control of respiration, ROS generation and scavenging, DNA maintenance, proteostasis, mitochondrial dynamics, and programmed cell death have previously been demonstrated to affect aging and life span. Here we ...
Chang Po-Chun PC Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, - - 2014
Background: Advanced glycation end products (AGEs) are involved in the inflammatory process and are considered to be etiologic factors of diabetic periodontitis. The purpose of this study is to investigate the capability of N-phenacylthiazolium bromide (PTB), a glycated cross-link breaker, in the modulation of periodontitis in various disease phases. Methods: ...
Li Hongliang H Heart Rhythm Institute, Department of Medicine, University of Oklahoma Health Sciences Center and Veterans Affairs Medical Center, Oklahoma City, OK 73104, - - 2014
It is well established that atrial fibrillation (AF) is far more common in elderly humans. Autonomic activation is thought to be an operative mechanism for AF propensity. The aim of the study was to investigate the impact of age on atrial tachyarrhythmia induction in a rabbit model. Six old (aged ...
Christian Sherri L SL Department of Chemistry and Biochemistry, Alaska Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA ; Department of Biochemistry, Memorial University of Newfoundland St. John's, NL, - - 2014
Hibernation is a unique physiological adaptation characterized by periods of torpor that consist of repeated, reversible, and dramatic reductions of body temperature, metabolism, and blood flow. External and internal triggers can induce arousal from torpor in the hibernator. Studies of hibernating animals often require that animals be handled or moved ...
Shi Cheng C Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, - - 2014
Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibility, and subsequent ...
Jouhanneau Mélanie M Laboratoire de Physiologie de la Reproduction et des Comportements, UMR 7247 INRA/CNRS/Université de Tours, Nouzilly, - - 2013
Testosterone-dependent olfactory signals emitted by male are well known to accelerate female puberty in mice (Vandenbergh effect). However, it remains unclear whether these chemosignals also influence adult expression of male-directed odor preference. Therefore, we exposed female mice to intact or castrated male bedding (vs clean bedding as control) during the ...
Reece A S AS School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, - - 2013
Despite intriguing initial and associational studies, there remains little research on opiate-related arterial dysfunction and no longitudinal studies. As opiates act potently via P16INK4A/CDKN2A identified on GWAS screens, and as arterial ageing is a surrogate for organismal ageing, this area is of general concern. Thirty-eight male controls compared with 198 ...
Sorrentino Jessica A - - 2014
While murine-based systems to identify cancer-promoting agents (carcinogens) are established, models to identify compounds that promote aging (gerontogens) have not been described. For this purpose, we exploited the transcription of p16INK4a, which rises dynamically with aging and correlates with age-associated disease. Activation of p16INK4a was visualized in vivo using a ...
Miller Justine D JD The Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA; Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA; Gerstner Sloan-Kettering Graduate School, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, - - 2013
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it to the modeling of Parkinson's ...
Umadevi Subramanian - - 2013
Advanced glycation en d products (AGEs) play a major role in the development of cardiovascular disorders in diabetic patients. Recent studies evidenced the beneficial role of phytochemicals in reducing the risk of cardiovascular diseases. Hence the present study was framed to investigate the protective role of Gallic acid (GA) on ...
Boyle Andrew J - - 2013
Aging is associated with higher incidence of heart failure and death following myocardial infarction (MI). The molecular and cellular changes that lead to these worse outcomes are not known. Young and aging mice underwent induction of MI by LAD ligation. There was a significant increase in mortality in the aging ...
Azim Hatem A HA Jr Jose Baselga, Memorial Sloan-Kettering Cancer Center, NY; James G. Greger Jr, GlaxoSmithKline, Collegeville, PA; Hatem A. Azim Jr, Martine Piccart, Evandro de Azambuja, BrEAST Data Centre, Institut Jules Bordet, Université Libre de Bruxelles; Phuong Dinh, Breast International Group, Brussels; Peter Vuylsteke, Sint-Elisabeth Hospital, Namur, Belgium; Dominique Agbor-tarh, Ian Bradbury, Frontier Science, Kincraig, Kingussie, Scotland; Ian Smith, Royal Marsden Hospital, and Institute of Cancer Research, London, United Kingdom; Serena Di Cosimo, IRCCS Fondazione Instituto Nazionale dei Tumori, Milan, Italy; Serena Di Cosimo, SOLTI Breast Cancer Research Group, Barcelona, Spain; Christian Jackisch, Kilinikum Offenbach, Offenbach; Bahriye Aktas, Kliniken Essen-Mitte, Evang, Essen; Holger Eidtmann, University Hospital Kiel, Kiel, Germany; Sung-Bae Kim, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Chiun-Sheng Huang, National Taiwan University Hospital; Ruey Kuen Hsieh, Mackey Memorial Hospital, Taipei, Taiwan; and Lydia Dreosti, University of Pretoria, Pretoria, South - - 2013
We investigated the pattern of rash, diarrhea, and hepatic adverse events (AEs) secondary to lapatinib and their association with age and pathologic complete response (pCR) in the Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (NeoALLTO) phase III trial. Patients with HER2-positive early breast cancer were randomly assigned to receive lapatinib (Arm ...
Yamasaki Kei - - 2013
The incidence of bepridil-induced pulmonary toxicity, such as interstitial pneumonia, is still unknown. The aim of the present study was to evaluate the incidence of bepridil-induced pulmonary toxicity. A total of 253 patients treated with bepridil between January 2009 and January 2011 were retrospectively evaluated. Eight out of the 222 ...
Gilbert John J JJ Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA. - - 2013
Brachionus calyciflorus typically develops long, defensive spines only in response to a kairomone from the predatory rotifer, Asplanchna. However, in the absence of any environmental induction, females of some clones produce daughters with increasingly long spines as they age; late-born individuals can have posterolateral spines as long as those induced ...
Chaplin Jay W JW Department of Immunology and 2 Molecular and Cellular Biology Program, University of Washington, Seattle, WA - - 2013
Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic cells (DCs), and then the Ag-anti-receptor is inoculated with an adjuvant. Here we report that targeting Ag to a receptor expressed on both B ...
Ismail Ahmad Filza - - 2013
Noise is known to be one of the environmental and occupational hazards listed in the Factory and Machinery Act 1967. Quarries with loud deafening sounds from trucks and machineries pose the risk of noise-induced hearing loss to workers. This study was designed to assess the knowledge, attitude and practice towards ...
Stapanian Martin A - - 2013
Concentrations of 86 congeners of polychlorinated biphenyls (PCBs) were determined for 25 adult female and 25 adult male burbot (Lota lota) from Lake Erie. Significant differences in mean proportions of total PCB concentration between males and females ages 14-17 were found for 26 congeners. Males generally had higher mean proportions ...
Hoyer Carolin - - 2013
Although preconceptional and periconceptional maternal stress is a recognized risk factor for offspring neurodevelopmental disturbances, less is known about the relevance of paternal exposures. These have hitherto been investigated mainly with respect to substance-induced impairment in the progeny. In recent years, experiential influences on offspring have come into focus through ...
Niu B - - 2013
/st>We determined the minimal alveolar concentration (MAC) of sevoflurane inducing an isoelectric EEG in 50% of adult subjects (MACie). /st>We included 31 middle-aged subjects; 30 subjects finished the study protocol and received sevoflurane at preselected concentrations according to a modified Dixon 'up-and-down' design starting at 1.7 vol% with 0.2 vol% ...
Adachi Yushi U - - 2013
The required dose of anesthetics is generally smaller in patients with low cardiac output (CO). A high CO decreases the blood concentration of anesthetics during induction and maintenance of anesthesia. However, a high CO may also shorten the delivery time of anesthetics to the effect site, e.g. the brain. We ...
Huang L - - 2013
/st>The ultrasound cardiac output monitor (USCOM) is a continuous wave Doppler system designed to measure cardiac output (CO) non-invasively and intermittently either from the pulmonary or from the aortic valve. USCOM scan quality is critical to obtaining reliable data and during anaesthesia it is said to deteriorate with increasing age. ...
Stanhewicz Anna E - - 2013
Reflex vasoconstriction is attenuated in aged skin due to a functional loss of adrenergic vasoconstriction. Bioavailability of tetrahydrobiopterin (BH4), an essential cofactor for catecholamine synthesis, is reduced with aging. Locally-administered BH4 increases vasoconstriction through adrenergic mechanisms in aged human skin. We hypothesized that oral sapropterin (Kuvan®, pharmaceutical BH4) would augment ...
Takeda Naoko - - 2013
Aging is a dominant risk factor for end-stage renal disease. We analyzed the mechanism involved in age-related exacerbation of proteinuria-induced proximal tubular cell (PTC) damage by focusing on endoplasmic reticulum-related unfolded protein response (UPR). After equal-degree induction of proteinuria in 24-month-old (aged) and 3-month-old (young) mice by intraperitoneal free fatty ...
Sharma Shilpa - - 2013
Herein, a green method for the development of a novel biodegradable silver nanoparticles (NPs) impregnated alginate-chitosan-blended nanocarrier (Ag NPs-Alg-Chi NC) is reported. The synthesis of Ag NPs-Alg-Chi NC is based on the polyelectrolyte complex formation between alginate and chitosan. The composite NC is characterized by ultraviolet-visible spectroscopy, transmission electron microscopy, ...
Chang Po-Chun - - 2013
Aim: Advanced glycation end products (AGE) have been found in inflamed gingival tissue and shown to interfere with the integrity of extracellular matrix and cell-matrix interactions. This study aimed to investigate the modulatory effect of aminguanidine (AG), an AGE inhibitor, in various stages of experimental periodontitis. Materials and Methods: Thirty-six ...
Nelms Brittany M BM Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, - - 2013
At temperate latitudes, Culex (Diptera: Culicidae) mosquitoes typically overwinter as adult females in reproductive arrest and also may serve as reservoir hosts for arboviruses when cold temperatures arrest viral replication. To evaluate their role in the persistence of West Nile virus (WNV) in the Sacramento Valley of California, the induction ...
1 2 3 4 5 6 7 8 9 10 >