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Shalev Idan I Department of Biobehavioral Health and The Network on Child Protection and Well-Being, Social Science Research Institute, The Pennsylvania State University, University Park, Pennsylvania; - - 2014
Perinatal complications predict increased risk for morbidity and early mortality. Evidence of perinatal programming of adult mortality raises the question of what mechanisms embed this long-term effect. We tested a hypothesis related to the theory of developmental origins of health and disease: that perinatal complications assessed at birth predict indicators ...
Preciado-Puga M C MC Departmente of Medical Science, Division of Health Science, University of Guanajuato, Campus - - 2014
Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did ...
DeLong Michael R MR Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North - - 2014
Deep brain stimulation (DBS) is a well-established modality for the treatment of advanced Parkinson disease (PD). Recent studies have found DBS plus best medical therapy to be superior to best medical therapy alone for patients with PD and early motor complications. Although no specific age cutoff has been defined, most ...
Stenhagen Ida S R - - 2013
The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-l-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).
Pastorelli Gianluca - - 2013
To enable conservation of amber in museums, understanding of chemical changes is crucial. While oxidation has been investigated particularly well for this natural polymer, further degradation phenomena in relation to humidity and pollutants are poorly studied or still unknown. Attenuated total reflectance-Fourier transform infrared spectroscopy was explored with regard to ...
Xie Shao-Hua - - 2012
BACKGROUND: Nasopharyngeal carcinoma (NPC) shows a male predominance in incidence while the underlying reasons have rarely been explored. METHODS: We analysed incident cases of NPC recorded in Hong Kong Cancer Registry during the period 1983-2008. All cases were divided into 5-year age groups. Age group specific incidence rates of NPC ...
Albuquerque Rui-Pionheiro - - 2012
The purpose of this study was to investigate the incidence of squamous cell carcinoma (SCC) of the anterior two thirds of the tongue in a population living in central and southern Portugal, all treated at Instituto Português de Oncologia de Lisboa, Francisco Gentil (IPOLFG). This study was a retrospective review ...
Titinchi Fadi - - 2012
J Oral Pathol Med (2012) Background:  Nevoid basal cell carcinoma syndrome (NBCCS) is a hereditary autosomal dominant syndrome presenting with a number of signs and symptoms in different population groups. Methods:  The investigators implemented a 40-year retrospective analysis of the clinical and radiological features of South Africans affected by NBCCS ...
Sahi Helka - - 2012
BACKGROUND: Statins (HMG-CoA-reductase inhibitors) are suggested to act as a predisposing factor for autoimmune diseases, have immunomodulatory effects, and possibly prevent some cancer types - the sum of these effects is unknown in cancers of viral aetiology, such as Merkel cell carcinoma (MCC). Aim of our study was to find ...
Zhang Yao Wei - - 2012
Mouse double minute 4 (MDM4) is a critical negative regulator of the tumor suppressor p53. The results of studies have revealed that an MDM4 polymorphism (rs1563828) may contribute to the earlier onset of several malignant diseases. However, the correlation between this polymorphism and nasopharyngeal carcinoma (NPC) susceptibility has not been ...
de Vries Esther - - 2012
OBJECTIVE: To estimate the population-based incidence of first and multiple basal cell carcinomas (BCCs) throughout Europe. DESIGN: The registry practices of 4 population-based cancer registries that routinely register BCC incidence were evaluated for inclusion of first and subsequent histologically confirmed BCCs. Where multiple BCCs were not routinely registered, comparisons with ...
Annertz Karin - - 2012
Abstract Conclusion: This study shows a persistent trend of an increase in the incidence of carcinoma of the tongue into the twenty-first century for both sexes and all age groups except for young males. Objectives: During the last decades increased incidence of squamous cell carcinoma (SCC) of the tongue in ...
Bilenchi Roberta - - 2012
  The term "ectopic nail" refers to nail tissue found in a location other than in the normal nail bed. Here we report a 9-year-old girl with an asymptomatic keratotic "horn" on the tip of her left fifth finger. Present since the age of 1 month, it was misdiagnosed as a ...
Al-Khalaf Huda H HH Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC #03-66, P.O. Box 3354, Riyadh, 11211, Saudi - - 2013
Survivin, an important anti-apoptotic protein, is highly expressed in most cancers, which generally arise in cells of older individuals. We have shown here accumulation of survivin and phospho-survivin in aged normal human skin fibroblasts and mice organs. This age-related accumulation of survivin was due to protein stabilization through association with ...
Peart Jason N - - 2012
We test the hypothesis that moderate calorie restriction (CR) reverses negative influences of age on molecular determinants of myocardial stress resistance. Postischemic contractile dysfunction, cellular damage, and expression of regulators of autophagy/apoptosis and of prosurvival and prodeath kinases were assessed in myocardium from young adult (YA; 2- to 4-month-old) and ...
Moore Michael G - - 2012
Background. Few studies have been done that characterize basal cell carcinoma (BCC) in Asians because this tumor is relatively uncommon in this population group. Objective. To characterize BCC in Asians. Methods. We retrospectively examined fifteen patient variables and eight tumor variables of ten Asian patients with BCC and compared these ...
Alt Eckhard U - - 2012
Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been long known that aging impedes an organism's repair/regeneration capabilities. In order to study the age associated changes, the molecular characteristics of adipose tissue derived MSCs (ASCs) from ...
Imai Takashi - - 2011
In antigen (Ag) cross-presentation, dendritic cells (DCs) take up extracellular Ag and translocate them from the endosome to the cytosol for proteasomal degradation. The processed peptides can enter the conventional MHC I pathway. The molecules responsible for the translocation of Ag across the endosomal membrane into the cytosol are unknown. ...
Lancaster T S TS Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, - - 2011
Reduced efficacy of cardioprotective interventions in the aged female heart, including estrogen replacement, highlights the need for alternative therapeutics to reduce myocardial ischemia-reperfusion (I/R) injury in postmenopausal women. Here, we sought to determine the efficacy of protein kinase-Cε (PKCε)-mediated cardioprotection in the aged, estradiol-deficient rat heart. Infarct size and functional ...
Holtzer Caleb - - 2011
PURPOSE:: To determine whether sociodemographic factors are associated with delays at specific steps in the diagnostic process of Duchenne and Becker muscular dystrophy. METHODS:: We examined abstracted medical records for 540 males from population-based surveillance sites in Arizona, Colorado, Georgia, Iowa, and western New York. We used linear regressions to ...
Vlajkovic Srdjan M SM Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand. - - 2011
This study was undertaken to determine the role of adenosine signalling in the development of age-related hearing loss (ARHL). We and others have shown previously that adenosine signalling via A(1) receptors is involved in cochlear protection from noise-induced cochlear injury. Here we demonstrate that enhanced adenosine signalling in the cochlea ...
Muazzam Sana - - 2011
Gross Domestic Product (GDP) and unemployment has a strong documented impact on injury mortality. The aim of our study is to investigate the relationship of GDP per capita and unemployment with gender- and cause-specific injury mortalities in the member nations of Organization for Economic Cooperation and Development (OECD). Country-based data ...
Wood Joanne M - - 2011
Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment among older adults. This study explored the relationship between AMD, fall risk, and other injuries and identified visual risk factors for these adverse events. Participants included 76 community-dwelling individuals with a range of severity of AMD (mean age, ...
Kalaiselvan Ganapathy - - 2011
To find out the prevalence of "all" injuries, its nature, outcome and sources of treatment among rural population of Pondicherry. It was a triangulated study of quantitative (survey) and qualitative (Focus Group Discussion, FGD) methods. The trained second year medical undergraduate students paid house visits to all houses in five ...
Rider Nicholas L - - 2011
Pyruvate kinase deficiency is a chronic illness with age specific consequences. Newborns suffer life-threatening hemolytic crisis and hyperbilirubinemia. Adults are at risk for infections because of asplenia, pregnancy-related morbidity, and may suffer organ damage because of systemic iron overload. We describe 27 Old Order Amish patients (ages 8 months-52 years) ...
Tank Elizabeth M H EM Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, - - 2011
The analysis of morphological changes that occur in the nervous system during normal aging could provide insight into cognitive decline and neurodegenerative disease. Previous studies have suggested that the nervous system of Caenorhabditis elegans maintains its structural integrity with age despite the deterioration of surrounding tissues. Unexpectedly, we observed that ...
Lee Choong Hyun - - 2011
In the present study, we compared HSP90 and its co-chaperone, p23, immunoreactivity and their protein levels in the hippocampus between adult (postnatal month 6) and aged (postnatal month 24) gerbils using immunohistochemistry and western blot analysis. HSP90 immunoreactivity was markedly increased in pyramidal cells in the hippocampus proper and in ...
Coronado Victor G - - 2011
Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Approximately 53,000 persons die from TBI-related injuries annually. During 1989-1998, TBI-related death rates decreased 11.4%, from 21.9 to 19.4 per 100,000 population. This report describes the epidemiology and annual rates of TBI-related deaths during ...
de la Cruz-Márquez J C - - 2011
Background An accentuated Quadriceps (Q) angle, genu valgum, flat feet, femoral anteversion, lumbar hyperlordosis and lower limb dysmetria can be factors favouring the occurrence of injuries. Objective To determine what degrees of Q angle can be tolerated by and what corrector guidelines can be established for volleyball players. Design A ...
Youngman Matthew J - - 2011
The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging in Caenorhabditis elegans, intestinal tissue deterioration and the increased intestinal proliferation of bacteria are observed, but how innate immunity changes during C. elegans ...
Ranney Megan L - - 2011
BACKGROUND: Violence is a leading cause of injury and death among adolescents. Reports indicate increasing incidence of violent injuries among adolescent females, but have not described characteristics of or charting completeness for these assault victims in the emergency department (ED). OBJECTIVES: To compare demographic and injury-related characteristics of assaulted urban ...
Saha Sukanta - - 2011
Individuals exposed to childhood trauma are more likely to report delusional-like experiences (DLE). This study examined the association between trauma exposure and DLE in a large community sample, investigating different trauma types and age-at-first-exposure to trauma. Subjects were from the Australian National Survey of Mental Health and Wellbeing 2007. Associations ...
Porto L - - 2011
PURPOSE: Chronic pituitary dysfunction is increasingly recognized as a sequela of traumatic brain injury (TBI). Our aim was to rule out any late morphometric changes of the pituitary gland and hypothalamus in survivors of TBI during childhood requiring intensive care. METHODS: We assessed morphometric abnormalities of the sella region and ...
Shamim Shahzad - - 2011
Our aim is to report the findings of the initial three years of road traffic injuries (RTI) surveillance at Karachi and to compare it with previously published RTI-related data from Pakistan and other low-and middle-income countries. Data were collected through the RTI surveillance programme at Karachi (RTIRP) from the five ...
Vrooijink Sharon H A - - 2011
PURPOSE: The primary purpose of this study was as follows: (1) to compare bony morphology in subjects with and without ACL injury. The secondary purposes were the following: (2) to compare bony morphology between men and women and (3) to determine whether MRI measurements of the notch correlate with intra-operative ...
Jacobsson L J - - 2011
The objective of the study was to assess sense of coherence (SOC) many years after traumatic brain injury (TBI) and explore the relationship between SOC and self-rated life satisfaction (LS) as well as measures of functioning and disability, sex, age at injury, injury severity and time post-injury. Sixty-six individuals (aged ...
McIntosh A - - 2011
Background Little is known about the injury incidence and risk factors in junior rugby union football. In particular, the timing of the introduction of the tackle, the skill associated with the highest incidence of injury, must be considered in the development pathway. Objective To measure the incidence of injury in ...
Mendonça L D - - 2011
Background Foot misalignments may contribute to development of sports injuries. Some evaluation protocols of foot alignment are not practical, have poor reliability and doesn't reflect functional foot behaviour. We propose a new measurement procedure to solve these problems. We also introduce the measure of the alignment of shank relative to ...
Jacobsson J - - 2011
Background Athletics is one of the most popular global sports, but little is known of injury patterns among élite athletic athletes. Injury prevalence has been proposed to be the most valid measure of injury burden in sports where athletes practice long hours and are at risk for overuse problems. Objective ...
Mendonça L D - - 2011
Background There is a high prevalence of shoulder injuries in volleyball and their preventive management is still a challenge. Isokinetic assessment is largely used in sports injury prevention. Few studies investigate the correlation between the isokinetic profile and injuries story, furthermore these studies analyses the agonist/antagonist ratio and do not ...
Shima Y - - 2011
Background The influence of psychological factors on injuries in female handball and basketball is poorly documented. Objective The aim of this study was to examine the influence of psychological factors on injuries in female handball and basketball players, especially for non-contact anterior cruciate ligament (ACL) injuries. Design Case control study. ...
Mendonça L D - - 2011
Background Knee injuries are prevalent in elite volleyball and their preventive management is still discussed. Isokinetic assessment is largely use in sports injury prevention; however few studies investigate the differences in the isokinetic profile of injured knees. These studies analyses the agonist/antagonist ratio and do not consider other parameters as ...
Scheetz Linda J - - 2011
Unintentional injuries are among the leading causes of death and disability in older adults. Although older adults account for approximately 12% of the US population, in 2008, they accounted for 15% of all traffic fatalities, 14% of all vehicle occupant fatalities, and 18% of all pedestrian fatalities. Severely injured older ...
Yeung Janice H H - - 2011
It has been suggested that women with traumatic brain injury have more favorable outcomes than do men because of higher levels of circulating estrogen and progesterone that may reduce brain edema. To determine whether there is any association between sex and mortality in TBI patients and whether there is any ...
Vlok Jennifer L - - 2011
Abstract -  Background/Aim: Few studies have investigated how patients feel about traumatic injuries to teeth. Dentists may focus on treating an injury and neglect to address how the patient views the severity, or aesthetics. Addressing these issues may improve trauma management and communication between dentists and patients. The aim of the ...
Jacobsson J - - 2011
Background Athletics is one of the most popular global sports, but also one of the most demanding with regard to human physical capacities. There are few prospective epidemiological studies available on athletic injury in populations of élite athletes. Objective To describe annual injury incidence rates among adult and youth elite ...
Guerrero Alejandro A Intertrauma Medical Consulting, 138 Mulberry Street, New York, NY 10013, USA. - - 2011
To provide a population-based analysis of childhood road traffic injuries (RTI) in two communities of the greater Accra region of Ghana, with the goal of establishing an RTI incidence baseline in these communities and to identify RTI characteristics in order to model a targeted injury prevention programme. Geographical cluster sampling ...
Beseler Cheryl L - - 2011
OBJECTIVE:: This study was designed to identify safety knowledge questions that differentiated those with high and low vulnerability to injury and assess differences in safety questions by sex and age. METHODS:: Colorado farm operators and their spouses were recruited in 1993 from farm truck registrations (n = 872) and between ...
Hedström Erik M - - 2011
OBJECTIVES: We present an overview of the injuries seen at the emergency department of a regional hospital in northern Sweden and the variations in the injury pattern with age, sex and time. METHODS: Data consisting of all injuries sustained by those 0-19years of age seen at the emergency department of ...
Esernio-Jenssen Debra - - 2011
Objective: To evaluate the effect of perpetrator gender on victim presentation and outcomes, and perpetrator legal outcomes for abusive head trauma (AHT). Methods: We performed a retrospective chart review of AHT cases from 1998 to 2008. Patient clinical data and information regarding perpetrator legal outcome was obtained. Relationship of brain ...
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