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Cecil C A M CA 0000000223895922 Institute of Psychiatry, King's College London, London, - - 2014
Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems is a key marker. However, it is unclear whether such a ...
Vos F I FI Fetal Medicine Unit, University Medical Centre Groningen, University of Groningen, The - - 2014
To evaluate the nasal bone length (NBL), the maxilla nasion mandible (MNM) angle, the fetal profile (FP) line, the prenasal thickness (PT), the prenasal thickness to nasal bone length (PT-NBL) ratio and the prefrontal space ratio (PFSR) as second and third trimester markers for trisomy 18 (T18). The NBL, MNM ...
Trinity Joel D JD Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, - - 2014
Reduced shear stress and augmented oscillatory shear rate are associated with the proatherogenic phenotype observed with aging. To date, mechanisms contributing to the age-related alterations in shear rate in humans have only been examined in the conduit vessels of the arm. Therefore, this study sought to examine the contribution of ...
Jo Hyun Jin HJ Seoul National University Bundang - - 2014
Little is known about the time-course of aging on interstitial cells of Cajal (ICC) of colon. The aim of this study was to investigate the change of morphology, ICC and neuronal nitric oxide synthase (nNOS) immunoreactive cells in the aged rat. The proximal colon of 344 Fischer rats at four ...
Sverdlov Aaron L AL University of Adelaide, The Queen Elizabeth Hospital, Adelaide, Australia (A.L.S., D.T.N., W.P.C., Y.Y.C., - - 2014
Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in aging are modulated by NO. We therefore postulated ...
Abu El Maaty Mohamed A MA Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Al Tagamoa Al Khames, New Cairo, 11835, - - 2013
Mounting evidence has presented nitric oxide (NO) and vitamin D (vitD) as having independently complex roles in osteoarthritis (OA). However, a mechanistic or an observational connection between them has never been investigated in the disease. This study investigates the correlation between circulating 25-hydroxyvitamin D [25(OH)D] and total NO as nitrate/nitrite ...
Novella Susana - - 2013
The present study investigated the time-course for aging-associated effects on contractile and relaxing vascular responses and nitric oxide (NO) production in aorta from female senescence-accelerated resistant (SAMR1) and prone (SAMP8) mice. Both SAMR1 and SAMP8 were studied at three different ages: 3-(young), 6-(middle age) and 10-(old) months. Concentration-response curves to ...
Stanhewicz Anna E - - 2013
Functional constitutive nitric oxide synthase (NOS) and its cofactor tetrahydrobiopterin(BH4) are required for full reflex cutaneous vasodilation, and are attenuated in primary aging. Acute locally-administered BH4 increases reflex vasodilation through NO-dependent mechanisms in aged skin. We hypothesized that oral sapropterin (Kuvan®, shelf-stable pharmaceutical formulation of BH4) would augment reflex vasodilation ...
Tenenbaum Shay S Department of Orthopedic Surgery, Chaim Sheba Medical Center, Tel Hashomer, - - 2013
Most studies on the prevalence of flexible pes planus (FPP) have been conducted in pediatric populations and older adults. There is limited comparable information on these parameters for the adolescent age group. The purpose of this study was to report the prevalence of FPP and its association with body mass ...
Zhang Yuan - - 2013
Hydrogen sulfide (H(2)S) is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H(2)S has been gaining increasing attention as an important endogenous signaling molecule because of its significant effects on the cardiovascular and nervous systems. Substantial evidence ...
Cheng Qiqing - - 2013
Tanshinones are abietane-type norditerpenoid quinone natural products found in a well-known traditional Chinese medicinal herb, Salvia miltiorrhiza Bunge. The copalyl diphosphate synthase of S. miltiorrhiza (SmCPS) is the key enzyme in the first step for transformation of geranylgeranyl diphosphate (GGPP) into miltiradiene, which has recently been identified as the precursor ...
Li X-H - - 2013
Accumulation evidence shows that β-amyloid (Aβ) is a neurotoxic and accumulation of Aβ is responsible for the pathology of Alzheimer's disease (AD). However, it is currently not fully understood what makes Aβ toxic and accumulated. Previous studies demonstrate that Aβ is a suitable substrate for glycation, producing one form of ...
Desdicioğlu Kadir K Department of Anatomy, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, - - 2012
In this study, morphometric developments of the sphincter of Oddi in human fetuses were observed. We observed 113 human fetuses consisting of 67 male and 46 female subjects, whose ages varied between 14 to 40 weeks who showed no signs of any pathology or anomaly externally. The common external measurements ...
Peterson Jennifer R - - 2012
This study examined changes in the acoustic and temporal structure of ultrasonic vocalizations as a function of age and correlated acoustic changes with vocal fold microstructure. Ultrasonic vocalizations were recorded in three age groups of male rats: aged (24-26 months), middle-aged (17-18 months), and young (4-5 months). Acoustic and structural ...
Han Chul C Department of Aging, Division of Biology of Aging, University of Florida, 1600 SW Archer Road, PO Box 100143, Gainesville, FL 32610-0143, - - 2013
Hearing loss is the most common sensory disorder in the elderly population. Overall, 10% of the population has a hearing loss in the US, and this age-related hearing disorder is projected to afflict more than 28 million Americans by 2030. Age-related hearing loss is associated with loss of sensory hair ...
Little Keriann - - 2012
This study explores the longitudinal pathways by which risk and protective factors influence the development of alcohol-related harms in a representative community sample of 941 young adults (19-20 years) from Victoria, Australia, focusing on the role of concurrent risky drinking. Impulsivity at 15-16 years, alcohol-related harms at 15-16 years and 17-18 years, frequency of ...
Sohn Seo Young - - 2012
The diagnosis of pheochromocytoma depends on the documentation of catecholamine overproduction. The use of urinary fractionated metanephrines has recently become common for the diagnosis of pheochromocytoma. In order to avoid false positive and false negative results, optimal cut-off levels are necessary; however, there have been few published reports on whether ...
Sato Hayato - - 2012
Listening difficulty ratings [Morimoto et al., J. Acoust. Soc. Am. 116, 1607-1613 (2004)] were obtained for 20 young adult listeners and 34 elderly listeners in reverberant and noisy sound fields simulated in an anechoic room. The listening difficulty ratings were compared with acoustical objective measures. The results and analyses showed ...
Lin Emily - - 2012
Aims: This study examined the viability of using iPhone recordings for acoustic measurements of voice quality. Methods: Acoustic measures were compared between voice signals simultaneously recorded from 11 normal speakers (6 females and 5 males) through an iPhone (model A1303, Apple, USA) and a comparison recording system. Comparisons were also ...
Kurniawan Clara - - 2012
Next to outer hair cell dysfunction, age-related hearing loss may be explained by apolipoprotein E (APOE) genotype. In the Leiden 85-plus Study, a population-based study, the participants were 85 years old. We measured hearing loss by pure-tone audiometry in 435 participants in relation to APOE. Results demonstrated that those with ...
Ichikawa Kotaro - - 2012
Previous studies have demonstrated that vocal signals facilitate acoustic communication of dugongs. We recorded wild dugong calls from around Talibong Island, Thailand (n = 586) and in Moreton Bay, Australia (n = 331). We also recorded vocalizations of a newborn calf (n = 315) kept at Phuket Marine Biological Center, ...
Gondim Lys Maria Allenstein - - 2012
The number of people with impaired hearing is increasing; knowing its magnitude is essential for public health. OBJECTIVE: To study the prevalence and determinants of impaired hearing in Itajaí/SC. METHODS: A population-based survey based on a World Health Organization protocol. Field research was carried out from July 2008 to 2011. ...
Lapshina Ekaterina N - - 2012
Individualistic voices are important for establishing personalized relationships among individuals. In young animals, individual vocal identity is affected by permanent changes of the acoustics due to the growth of their vocal apparatus. Different acoustic variables change uncoordinatedly, so vocal individuality should be repeatedly upgraded along development. We compared classifying accuracy ...
Mishima Katsuaki - - 2012
OBJECTIVES: The purpose of this study was to explore the voice characteristics of patients with mandibular prognathism, and to investigate the effects of mandibular setback surgery on these characteristics using nonlinear dynamics and conventional acoustic analyses. MATERIALS AND METHODS: Sixteen patients (8 males and 8 females) who had skeletal 3, ...
Teunisse Robert J - - 2012
OBJECTIVE:: To assess the prevalence of musical hallucinations in patients referred for audiometric testing and to analyze associations with age, sex, degree of hearing loss, asymmetrical hearing loss, and tinnitus. METHODS:: Patients referred for audiometric testing underwent a semi-structured interview on tinnitus and musical hallucinations. RESULTS:: Out of 194 patients, ...
Muchitsch A P - - 2012
Muchitsch A. P., Winsauer H., Wendl B., Pichelmayer M., Kuljuh E., Szalay A., Muchitsch M. Remodelling of the palatal dome following rapid maxillary expansion (RME): laser scan-quantifications during a low growth period. Orthod Craniofac Res 2012;15:30-38 © John Wiley & Sons A/S STRUCTURED ABSTRACT: Objectives -  To evaluate changes in the ...
Mora Renzo - - 2012
The aim of this study was to evaluate changes in the acoustic features of voice in patients with sensorineural hearing loss. Thirty male patients, between 35 and 53 years of age with postlingual bilateral symmetric severe sensorineural hearing loss, were included (group A). As a control group (group B), 30 ...
Verhoef L - - 2012
SUMMARYHepatitis E virus (HEV) is now considered an endemic pathogen in industrialized countries, leading to acute and sometimes chronic hepatitis, mostly in vulnerable people. The endemic sources are unclear. A survey in The Netherlands in 2006-2007 showed a 1·9% seroprevalence of HEV antibodies measured by ELISA and confirmed by immunoblot ...
Scanlan Aaron T - - 2012
OBJECTIVES: To describe the physiological and activity demands experienced by Australian female basketball players during competition. DESIGN: A between-subjects (positional comparison) repeated measures (playing periods) observational experimental design was followed. METHOD: State-level basketball players (n=12; age: 22.0±3.7yr; body mass: 72.9±14.2kg; stature: 174.2±6.9cm; body fat: 17.2±5.6%; estimated V˙O(2max):43.3±5.7 ml kg(-1) min(-1)) volunteered to participate. ...
Lai Der-Chung - - 2012
The prevalence of autism spectrum disorders (ASD) in the world has increased dramatically in the recent decades. However, data at the national level are limited, and geographic differences are seldom evaluated. According to the law, the local governments in Taiwan began to certify disabled residents and provide various services in ...
Barros Fernando C FC Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Brazil. - - 2012
The number of cesarean sections (CSs) is increasing in many countries, and there are concerns about their short- and long-term effects. A recent Brazilian study showed a 58% higher prevalence of obesity in young adults born by CS than in young adults born vaginally. Because CS-born individuals do not make ...
Leong Yin-Hui - - 2012
Aflatoxins are one of the major risk factors in the multi-factorial etiology of human hepatocellular carcinoma. Therefore, the information on aflatoxins exposure is very important in the intervention planning in order to reduce the dietary intake of aflatoxins, especially among the children. This study investigated the relationship between aflatoxin B(1) ...
Astorino Todd A - - 2012
Astorino, TA, Allen, RP, Roberson, DW, and Jurancich, M. Effect of high-intensity interval training on cardiovascular function, &OV0312;o2max, and muscular force. J Strength Cond Res 26(1): 138-145, 2012-The purpose of this study was to examine the effects of short-term high-intensity interval training (HIIT) on cardiovascular function, cardiorespiratory fitness, and muscular ...
Dahm Theresa - - 2012
[This corrects the article on p. e26351 in vol. 6.].
Puca Annibale Alessandro - - 2012
Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was ...
John Andrew B - - 2012
Worker's compensation for hearing loss caused by occupational noise exposure is calculated by varying methods, from state to state within the United States (US), with many employing arithmetic formulas based on the pure-tone audiogram, to quantify hearing loss. Several assumptions unsupported or weakly supported by empirical data underlie these formulas. ...
Gochuico Bernadette R - - 2012
Pulmonary fibrosis develops in Hermansky-Pudlak syndrome (HPS) types 1 and 4. Limited information is available about lung disease in HPS type 2 (HPS-2), which is characterized by abnormal function of the adaptor protein-3 (AP-3) complex. To define lung disease in HPS-2, one child and two adults with HPS-2 were evaluated ...
Tong Youren - - 2012
Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses ...
Wells Deborah L - - 2011
For the first time, the development of paw preferences in the domestic cat, Felis silvestris catus, is explored. Twelve cats were tested at ages 12 weeks, 6 months, and 1 year on a challenge requiring them to use one of their paws to retrieve food. To control for repeated testing ...
Kwan Mun Keong - - 2011
INTRODUCTION: Studies of sacral pedicle anatomy have been reported in the European population. However, the feasibility for the use of S1, S2 and S2-ilium screws has not been fully investigated in the Asian population. PURPOSE: To assess feasibility, morphometric parameters and safety of S1, S2 and S2-ilium screw insertion in ...
Carpita Adriano - - 2011
It is well-known that Bactrocera oleae (olive fruit fly) females attract conspecific males by using 1,7-dioxaspiro[5,5]undecane (1) as the main component of their sex pheromone, and that 1 is produced in the female rectal gland. Although some authors have claimed that B. oleae males also attract females, to date no ...
de Paula Viveiros J - - 2011
The aging process may impair exercise tolerance in the heat. It is not clear whether this impairment is partly due to a reduction in aerobic capacity. To compare the exercise performance and thermoregulatory responses of middle-aged and young adults with similar aerobic capacities and training statuses, 7 middle-aged (54±2 years; ...
Stanhewicz Anna E - - 2012
Functional constitutive nitric oxide synthase (NOS) is required for full expression of reflex cutaneous vasodilation that is attenuated in aged skin. Both the essential cofactor tetrahydrobiopterin (BH(4)) and adequate substrate concentrations are necessary for the functional synthesis of nitric oxide (NO) through NOS, both of which are reduced in aged ...
Hirose Jun - - 2011
OBJECTIVE: To study the effects of aging and cartilage degeneration of the proximal tibiofibular- and femorotibial joint (PTFJ, FTJ) on the cartilage of the PTFJ using T(1)ρ and T(2) mapping. MATERIALS AND METHODS: We performed sagittal T(1)ρ and T(2) mapping of the PTFJ and FTJ on 55 subjects with knee ...
Okada Rieko - - 2011
BACKGROUND: This study aimed to investigate the associations of hyperfiltration and hypofiltration with prediabetes and prehypertension.METHODS: The study subjects included 99 140 people aged 20-89 years who underwent health checkups in Aichi Prefecture, Japan. The prevalence of hyperfiltration [estimated glomerular filtration rate (eGFR) above the age-/sex-specific 95th percentile] and hypofiltration (eGFR ...
Giffin Nick A - - 2011
Abstract The second to fourth digit ratio (2D:4D) is a sexually dimorphic trait with lower finger ratios considered more masculine. These digit ratios are believed to reflect the prenatal hormonal environment with higher exposure to androgens in utero leading to more masculine digit ratios. The 2D:4D ratio has been negatively ...
Stein-Zamir C - - 2011
SUMMARYWe investigated a measles outbreak in the Jerusalem district in 2007-2008 (992 cases). Most cases (72·6%) were aged <15 years, 42·9% aged <5 years, and 12·8% were infants aged <1 year. The peak incidence rate was in infants aged 6-12 months (916·2/100 000). This represents a significant shift from former ...
Byard Roger W - - 2011
Aim:  To determine whether there is a gender imbalance in infant deaths in shared sleeping compared to solitary sleeping situations. Methods:  Examination of autopsy reports of 133 infants aged between 7 and 364 days autopsied over a 19-year period from January 1991 to December 2009 was undertaken where death had ...
Dávila S G - - 2011
The purpose of this study was to analyze the effect of auditory enrichment (by means of classical music) or physical enrichment (by means of hanging colored string bunches and barley grains on the floor) on tonic immobility duration, heterophil to lymphocyte ratio, and fluctuating asymmetry (FA) in chicks of several ...
Mohan Kanwar - - 2011
To find the optimal dosage of cyclopentolate 1% for cycloplegic refraction in hypermetropes with brown irides, we investigated the difference in cycloplegic auto-refractions obtained after one, two, and three instillations in the same patient. The mean hypermetropia found after three instillations was statistically significantly more compared to that found after ...
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