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Bove R R Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, - - 2014
Gonadal steroids may modulate disease course in multiple sclerosis (MS). To assess the prevalence and clinical associations of hypogonadism in men with MS. Male patients, aged 18-65 years, with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) and their first symptom < 10 years prior were selected from a longitudinal clinical ...
Celojevic Dragana D Department of Clinical Neuroscience and Rehabilitation/Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg , Gothenburg , Sweden - - 2014
Abstract Background: Ephrin receptors (Ephs) are tyrosine kinases that together with their ligands, ephrins, are considered important in cell-cell communication, especially during embryogenesis but also for epithelium homeostasis. Studies have demonstrated the involvement of mutations or common variants of the gene encoding Eph receptor A2 (EPHA2), in congenital cataract and ...
Koyanagi Takashi T Ono Pharmaceutical Co., Ltd., Mishima-gun , Osaka , Japan - - 2014
Abstract 1.  The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in cynomolgus monkeys (3-18 years old) and beagle dogs (2-11 ...
Schrack Jennifer A JA Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, - - 2014
To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults. Cross-sectional analysis. Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (BLSA). Persons aged 40 to 96 (mean 68.2 ± 11.0) who underwent a comprehensive physical examination, cognitive assessment, RMR testing, body ...
Tackney Justin J Department of Anthropology, University of Utah, Salt Lake City, Utah, - - 2014
Slower rates of aging distinguish humans from our nearest living cousins. Chimpanzees rarely survive their forties while large fractions of women are postmenopausal even in high-mortality hunter-gatherer populations. Cellular and molecular mechanisms for these somatic aging differences remain to be identified, though telomeres might play a role. To find out, ...
McComb Karen K Mammal Vocal Communication and Cognition Research, School of Psychology, University of Sussex, Brighton BN1 9QH, United - - 2014
Animals can accrue direct fitness benefits by accurately classifying predatory threat according to the species of predator and the magnitude of risk associated with an encounter. Human predators present a particularly interesting cognitive challenge, as it is typically the case that different human subgroups pose radically different levels of danger ...
Matysioková Beata - - 2014
Male contribution to parental care varies widely among avian species. Yet the reasons for this variation, as well as its consequences, are still unclear. Because the amount of care provided by one sex is ultimately constrained by the time available for energy acquisition, contribution by the other sex should increase ...
Peters Erica N EN From the Friends Research Institute (ENP, FJV), Baltimore, MD; Yale University School of Medicine (ENP), New Haven, CT; Department of Health Behavior (PSH), University of Alabama at Birmingham School of Public Health, Birmingham, AL; and Department of Psychiatry and Behavioral Neurobiology (CBC, KLC), The University of Alabama at Birmingham, Birmingham, - - 2014
African American youth who use marijuana are less likely to attend and complete treatment than white youth. Limited information is available on racial and age variation in treatment attendance and completion among adults who use marijuana. The current research examined differences in community-based substance abuse treatment attendance and completion between ...
Kempinska-Podhorodecka Agnieszka A Medical Biology Laboratory Pomeranian Medical University, Szczecin, Poland. - - 2014
The common PNPLA3 (adiponutrin) variant p.I148M represents a major genetic driver of progression in non-alcoholic fatty liver disease (NAFLD). NAFLD is commonly associated with traits of the metabolic syndrome, therefore it is mostly suspected in obese individuals. Here, we investigate the association between the PNPLA3 variant and anthropometric traits in ...
Chung Ping-Lin PL Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
Human skeletal aging is characterized as a gradual loss of bone mass due to an excess of bone resorption not balanced by new bone formation. Using human marrow cells, we tested the hypothesis that there is an age-dependent increase in osteoclastogenesis due to intrinsic changes in regulatory factors [macrophage-colony stimulating ...
Ayyavoo Ahila A Liggins Institute, University of Auckland, Auckland, New Zealand; Gravida: National Centre for Growth and Development, Auckland, New - - 2014
We aimed to assess possible differences in insulin sensitivity and other metabolic, anthropometric and cardiovascular parameters between boys and girls prior to puberty. We studied 85 healthy prepubertal children (33 girls and 52 boys) aged 8·7 ± 1·9 years (range 4·0-11·9 years), born 38-40 weeks gestation, and of birth weight appropriate-for-gestational-age. Insulin sensitivity was measured ...
Kelly Daniel F DF John Wayne Cancer Institute at Saint John's Health Center, Director, Brain Tumor Center, 2200 Santa Monica Blvd, Santa Monica, California, United States, 90404 ; - - 2014
Hypopituitarism is common after moderate and severe traumatic brain injury (TBI). Herein we address the association between mild TBI and pituitary and metabolic function in retired football players. NFL retirees aged 30-65 years with poor quality of life (QoL) were prospectively enrolled. Pituitary and metabolic syndrome testing was performed. Using ...
Elder Natalie M NM 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, - - 2014
Oxycodone is an opioid analgesic metabolized to oxymorphone and noroxycodone by cytochrome P450 (CYP) 2D6 and 3A4/5, respectively. This was a retrospective study to evaluate sex, age, urinary pH and concurrent medication use on oxycodone, oxymorphone and noroxycodone distributions. Urine specimens obtained from patients on chronic opioid therapy were analyzed ...
Van Dongen Stefan S Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, - - 2014
Ratios of digit lengths are studied intensively as markers of prenatal sex hormone levels. Study sexual dimorphism in ratios of metacarpals, which received less attention. We studied six metacarpal ratios in deceased human fetuses of ages 10 to 42weeks. We found no indication of a sexual dimorphism at this early ...
Gusella Milena M Department of Oncology, ULSS 18-Rovigo, S Maria della Misericordia Hospital, Rovigo General Hospital, Viale Tre Martiri 140, 45100, Rovigo, Italy, - - 2014
Pegylated liposomal doxorubicin (PLD) is often used in elderly people, due to its improved tolerability. However, clinical and pharmacological data in the subset of patients over 70 are scanty. PLD safety was evaluated in 35 patients (aged ≥70 years) who were treated with PLD as a single agent for 165 cycles. ...
Alharbi Khalid Khalaf KK Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi - - 2014
Rising levels of obesity are a global problem that is being exported from affluent to developing nations through the gradual "westernization of lifestyle". Population of Saudi Arabia is going through a nutrition transition where customary and traditional food is being replaced by fast food high in fat, sugar and salt. ...
Rolandsson M M Department of Health Sciences, Oral Health, Karlstad University, Karlstad, - - 2014
This study examined the prevalence of tobacco habits and the influence of the social environment among Swedish female athletes representing both individual and team sports in Sweden. A self-reported cross-sectional survey was performed with 791 female athletes 15-24 years old representing ten of the most common sports in Sweden. The questions ...
Stewart Kelly R KR Marine Mammal and Turtle Division, Southwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, La Jolla, California, United States of America ; The Ocean Foundation, Washington D. C., United States of - - 2014
For vertebrates with temperature-dependent sex determination, primary (or hatchling) sex ratios are often skewed, an issue of particular relevance to concerns over effects of climate change on populations. However, the ratio of breeding males to females, or the operational sex ratio (OSR), is important to understand because it has consequences ...
Baessler A A Clinic for Internal Medicine II, University of Regensburg, Regensburg, - - 2014
Objectives:This study aimed to examine the association of adipocyte fatty acid-binding protein (FABP4) levels with left ventricular diastolic dysfunction (LVDD) in obese subjects with varying degrees of the metabolic syndrome (MetS).Methods:Fifty morbidly obese subjects with LVDD were selected at random and matched by age (±5 years) and sex with 50 ...
Graversen Lise L Section for General Medical Practice, Department of Public Health, Aarhus University, Aarhus, - - 2014
If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high risk children is possible. The aim of this study was to test the associations between preschool weight and ...
Khonmee Jaruwan J Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, - - 2014
Chinese goral (Naemorhedus griseus) are a threatened species in Thailand and the focus of captive breeding for possible reintroduction. However, little is known of their biology or what factors in the captive environment affect welfare. Our objective was to determine the impact of gender, season, and management on goral adrenal ...
Bastiaans Elizabeth E Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California, United States of - - 2014
Color polymorphic sexual signals are often associated with alternative reproductive behaviors within populations, and the number, frequency, or type of morphs present often vary among populations. When these differences lead to assortative mating by population, the study of such polymorphic taxa may shed light on speciation mechanisms. We studied two ...
Devito Elise E EE Yale University, School of Medicine, Department of Psychiatry, New Haven, CT, - - 2013
Nicotine dependence is a serious public health concern. Optimal treatment of nicotine dependence will require greater understanding of the mechanisms that contribute to the maintenance of smoking behaviors. A growing literature indicates sex and menstrual phase differences in responses to nicotine. The aim of this study was to assess sex ...
Jeong Seo-Won SW Orthopaedic Research Center, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 62 Yoido-dong, Youngdeungpo-ku, Seoul 150-010, - - 2013
Our previous in vivo study demonstrated that human nucleus pulposus chondrocytes (NPCs) in aging discs exhibited characteristic senescent features such as an increased senescence-associated β-galactosidase (SA-β-gal) expression, shortened telomere, and decreased telomerase activity. The replicative p53-p21-pRB pathway, rather than the stress-induced p16-pRB pathway, played a more important role in the senescence ...
Tassiopoulos Katherine - - 2013
Hepatitis C infection (HCV) among individuals aged 15-24 years has increased in Massachusetts, likely due to injection drug use. The prevalence of injection equipment sharing (sharing) and its association with age was examined in a cohort of out-of-treatment Massachusetts substance users. This analysis included baseline data from a behavioral intervention ...
Schröder Helmut - - 2013
There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year ...
Walters Glenn D - - 2013
The relationship between childhood cruelty toward animals and subsequent aggressive offending was explored in 1,336 (1,154 male, 182 female) participants from the 11-wave Pathways to Desistance study (Mulvey, 2013). Aggressive and income offending at Waves 1 through 10 were regressed onto a dichotomous measure of prior involvement in animal cruelty ...
Trompetto Carlo - - 2013
Post-activation depression (PaD) refers to the inhibition of the H-reflex induced by a preceding conditioning stimulus able to activate the afferents mediating the H-reflex itself. PaD can be investigated assessing the frequency-related depression of the H-reflex. This parameter, which is highly correlated to the severity of spasticity, has been used ...
Xu L - - 2013
Previous small studies examining differences in testosterone concentrations by ethnicity found mixed results for Caucasians and Chinese men, which might be confounded by age differences and living standards. The aim of the present study is to examine the differences in total, free, and bioavailable testosterone concentrations between healthy young men ...
Walter L J - - 2013
Beef cattle from three independent studies conducted in the Texas panhandle (Experiment 1; n = 3,906 and Experiment 2; n = 4,000) and southern Idaho (Experiment 3; n = 542) were used to investigate the association of pro-melanin-concentrating hormone (PMCH) genotype with beef carcass quality and yield attributes. Tissue samples ...
Claessen Kim M J A - - 2013
BACKGROUNDADULT GH DEFICIENCY (GHD) IS ASSOCIATED WITH INCREASED CARDIOVASCULAR MORTALITY. RECOMBINANT HUMAN GH (RHGH) REPLACEMENT HAS BENEFICIAL SHORT-TERM METABOLIC EFFECTS. ALTHOUGH THESE POSITIVE EFFECTS SUSTAIN DURING LONGER FOLLOW-UP, THE PREVALENCE OF THE METABOLIC SYNDROME (MS) REMAINS INCREASED IN COMPARISON WITH POPULATION DATA NOT ADJUSTED FOR THE HIGHER MEAN BMI IN ...
Ferkin Michael H - - 2013
Many nonhuman animals are capable of discriminating a group or entity containing more objects from one containing less of the same objects. The capacity for making judgments of numerousness may also allow individuals to discriminate between potential mates. Female meadow voles (Microtus pennsylvanicus) may use judgments of relative numerousness to ...
Tseng Alice - - 2013
Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population. To investigate the association of age with potential drug-drug interactions (PDDIs) involving ARVs. We studied ARV-treated patients attending a tertiary care center. PDDIs were classified as "red flag" (contraindicated) or ...
Corona Giovanni G Sexual Medicine and Andrology Unit Department of Experimental, Clinical, and Biomedical Sciences, University of Florence, Florence, Italy; Endocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore-Bellaria Hospital, Bologna, - - 2013
We previously reported that in male patients consulting for sexual dysfunction, low prolactin (PRL) levels were associated with metabolic syndrome (MetS), arteriogenic erectile dysfunction, and incident major cardiovascular events. The aim of this study is to assess the clinical associations of PRL levels in the European Male Ageing Study (EMAS). ...
Kim Sangkyu - - 2013
Previously, we showed that FI34, a frailty index based on 34 health and function ability variables, is heritable and a reliable phenotypic indicator of healthy aging. We have now examined the relationship between major components of energy expenditure and the FI34 in participants of the Louisiana Healthy Aging Study. Resting ...
Salem Ahmed H - - 2013
The aim of this analysis was to create a pharmacometric model of efavirenz developmental pharmacokinetics and pharmacogenetics in HIV-infected children. Data consisted of 3,172 plasma concentrations from 96 HIV-1 infected children who participated in the Pediatric AIDS Clinical Trials Group 382 (PACTG382) study. Analyses were performed using NONMEM and the ...
Hanssen Nordin M J - - 2013
Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) and their major precursor methylglyoxal are formed during high metabolic activity and can have detrimental effects on cellular function and may induce cell death. Therefore, we investigated ...
Justice Jamie N - - 2013
Motor function in humans can be characterized with tests of locomotion, strength, balance, and endurance. The aim of our project was to establish an analogous test battery to assess motor function in mice. Male C57BL/6 mice were studied at 3 (n = 87), 20 (n = 48) and 26 (n = 43) months of age. Tests ...
Huzen Jardi - - 2013
Human age-dependent telomere attrition and telomere shortening are associated with several age-associated diseases and poorer overall survival. The aim of this study was to determine longitudinal leukocyte telomere length dynamics and identify factors associated with temporal changes in telomere length. Leukocyte telomere length was measured by quantitative polymerase chain reaction ...
Lian W-C - - 2013
Type-2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term 'ominous octet' had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS. We ...
Kanchan Tanuj - - 2013
Estimation of sex is an important step in the evaluation of unknown human remains. Human skulls are shown to exhibit sexual dimorphism. The objective of the present study was to assess the mastoid region in sexing of unknown skulls. The present study was conducted on 118 (69 males and 49 ...
Tripathi Ravi S RS Department of Anesthesiology, Division of Critical Care, Critical Care and Burn, The Ohio State University Medical Center, 410 West 10 Avenue, Columbus, Ohio 43210, - - 2013
Here we posit for discussion the example of a reversible metabolic encephalopthy in a very elderly male that was missed clinically. A metabolic encephalopathy in extrememly elderly patients may be confused with delerium or inattention. A reversible cause of cognative dysfunction in the aged may be missed by practitioners because ...
Okuda Tomoko - - 2013
This study was initiated to investigate if spousal concordance in metabolic syndrome (MS) components exist in Japan. In all, 756 couples (mean age: 48.9 and 47.3 years for husbands and wives, respectively) were identified. Each subject was classified as an MS, MS reserves (MSRES) or no risk of MS (NonMS) case ...
Lee Jun Ho - - 2013
To evaluate which among the lower urinary tract symptom (LUTS)/benign prostatic hyperplasia (BPH) measures is the most relevant to erectile dysfunction (ED) and elucidate the role of metabolic syndrome (MetS) and testosterone in their relationship. A total of 2564 policemen aged 40-59 years who had participated in a health examination ...
Louie S G - - 2013
Background:The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on the disposition of capecitabine and its metabolites, the pharmacokinetics between patients 70 years and <60 years were compared in SWOG0030.Methods:Twenty-nine ...
Lindberg Magnus - - 2013
The aim of this study was to determine self-reported consumption of dermatological pharmaceuticals and quality of life (QoL), measured with Short Form 36, in relation to eczema, acne, psoriasis and other inflammatory skin conditions in the Swedish population. A questionnaire containing questions on the occurrence of skin diseases, health-related QoL ...
Müller Manfred J - - 2013
To present recent evidence on organ and tissue metabolic rates in humans to explain the variance in resting energy expenditure (REE). In humans, present knowledge on specific metabolic activities (i.e. ki-values) refers to seven organs and tissues - brain, heart, liver, kidneys, skeletal muscle, adipose tissue and residual mass - ...
Lecardonnel Jennifer - - 2013
The decline of tissue regenerative potential of skin and hair is a hallmark of physiological ageing and may be associated with age-related changes in tissue-specific stem cells and/or their environment. Human hair follicles (hHF) contain keratinocytes having the property of stem cells such as clonogenic potential. Growth capacity of hHF ...
Trumble Benjamin C - - 2013
Testosterone plays an important role in mediating male reproductive trade-offs in many vertebrate species, augmenting muscle and influencing behavior necessary for male-male competition and mating-effort. Among humans, testosterone may also play a key role in facilitating male provisioning of offspring as muscular and neuromuscular performance are deeply influenced by acute ...
Missoni Sasa - - 2013
The study deals with the connection between metabolic syndrome (MS) and smoking habits of 1602 males and 828 females aged 18-97 years from the island of Hvar, Croatia. The age-adjusted prevalence of MS was higher in males (18.1-31.2%) than females (9.7-24.2%) by all five criteria that were defined, except the ...
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