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Lichter D G DG The Departments of Neurology and Psychiatry, School of Medicine and Biomedical Sciences, University at Buffalo, VA Western NY Healthcare System, 3495 Bailey Avenue, Buffalo, NY 14215, USA. Electronic address: - - 2014
Although boys are disproportionately affected by tics in Tourette syndrome (TS), this gender bias is attenuated in adulthood and a recent study has suggested that women may experience greater functional interference from tics than men. The authors assessed the gender distribution of adults in a tertiary University-based TS clinic population ...
Bouglé D D Service de Pédiatrie, CHU de Caen, - - 2014
Objectives:  High TSH levels often observed in overweight subjects are associated with metabolic risk. Thyroid hormones which are involved in fat and carbohydrates metabolism are more rarely studied; their blood levels were measured to more precisely explain the relationships between thyroid function and obesity, in healthy overweight youth. This correlation ...
Marcovecchio M Loredana ML Department of Paediatrics, University of Chieti, Chieti, - - 2014
Background: To assess whether previously identified obesity-susceptibility loci were associated with overweight/obesity risk in a homogeneous population of Caucasian schoolchildren and whether these associations varied with age. Methods: Seven hundred and forty-five schoolchildren (353 boys, mean age: 8.3 ± 1.4 years) underwent anthropometric assessments. A saliva sample was collected for ...
Benmohammed K K Department of Endocrinology, Diabetology and Nutrition, Ben Badis University Hospital, Metabolic diseases research laboratory, University of Constantine 3, 2500 - - 2014
This study aimed to estimate, in a large group of Algerian adolescents, the prevalence of the metabolic syndrome (MetS), using four definitions (by Cook, De Ferranti, Viner and the IDF), and to test the validity of unique thresholds of waist circumference, waist/height ratio and BMI in screening for the MetS ...
Twig Gilad G Department of Medicine - - 2014
Context: The natural progression of metabolic abnormalities among patients with inherited auto-inflammation is unclear. Objective: To assess the cardio-metabolic risk of participants with familial Mediterranean Fever (FMF). Design & Setting: Nationwide cross-sectional and longitudinal cohorts. Participants: The prevalence of components of the metabolic syndrome at age 17 was assessed from ...
Soler C C Departament de Biologia Funcional i Antropologia Física, Universitat de València, Burjassot, - - 2014
Phenotype-linked fertility hypothesis (PLFH) predicts that male secondary sexual traits reveal honest information about male fertilization ability. However, PLFH has rarely been studied in humans. The aim of the present study was to test PLFH in humans and to investigate whether potential ability to select fertile partners is independent of ...
Watkins Deborah J DJ Department of Epidemiology, Brown University , Providence, Rhode Island 02912, United - - 2014
The variability and predictors of urinary concentrations of phthalate metabolites in preschool-aged children have not been thoroughly examined. Additionally, the impact of temporal changes in the use and restriction of phthalates in children's products has not been assessed. Our objective was to identify demographic, behavioral, and temporal predictors of urinary ...
Wert David M DM Department of Physical Therapy, University of Pittsburgh, Pittsburgh, - - 2014
The purpose of this study was to assess the relative and absolute reliability of metabolic measures of energy expenditure and gait speed during overground walking in older adults with mobility limitation. Thirty-three [mean age (SD), 76.4 (6.6) years, 66% female] older adults with slow gait participated. Measures of energy expenditure ...
Lukas Dieter D Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK - - 2014
Although differences in breeding lifespan are an important source of variation in male fitness, the factors affecting the breeding tenure of males have seldom been explored. Here, we use cross-species comparisons to investigate the correlates of breeding lifespan in male mammals. Our results show that male breeding lifespan depends on ...
Webb David D Department of Anthropology, Kutztown University, Kutztown, - - 2014
In 1965, Ciur-Izbuc Cave in the Carpathian Mountains of Romania was discovered to contain about 400 ancient human footprints. At that time, researchers interpreted the footprints to be those of a man, woman and child who entered the cave by an opening which is now blocked but which was usable ...
Ayalon Nir N Cardiovascular Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, - - 2014
Metabolic syndrome (MS) is commonly associated with left ventricular (LV) diastolic dysfunction and LV hypertrophy. We sought to examine whether preclinical LV diastolic dysfunction can occur independent of LV hypertrophy in MS. We recruited 90 consecutive participants with MS and without cardiovascular disease (mean age 46 years, 78% women) and 26 ...
Terao Chikashi C Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Objective: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) are markers to rheumatoid arthritis (RA). Smoking and shared epitope (SE) in HLA-DRB1 are associated with the production of these autoantibodies in RA. Detailed distribution and characterization of ACPA and RF in the general population has remained unclear. We aimed to ...
Meador Kimford J KJ Department of Neurology and Neurological Sciences, Stanford University, Stanford, - - 2014
IMPORTANCE Breastfeeding is known to have beneficial effects, but concern exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful. We previously noted no adverse effects of breastfeeding associated with AED use on IQ at age 3 years, but IQ at age 6 years is more predictive of ...
Nazir Shabnam S Kohat University of Science and Technology, Kohat, Pakistan, - - 2014
Rosuvastatin is used to treat dyslipidemia and is metabolized by CYP2C9 that shows variable metabolic activity in males and females. Pharmacokinetics (PK) of drugs varies in males and females that may result in altered drug response and therapeutic efficacy. In current study, PK of rosuvastatin has been evaluated in males ...
González L L Institute of Nutrition and Food Technology, University of Chile, Santiago, - - 2014
Background:Early adiposity rebound (< age 5y; AR) has been consistently associated with increased obesity risk, but its relationship with metabolic markers is less clear; in addition the biological mechanisms involved in these associations have not been established.Objective:We assess the association between timing of AR and metabolic status at age 7, ...
Metti Andrea L AL Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: - - 2014
We aimed to examine trajectories of inflammatory markers and cognitive decline over 10 years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70-79 years in the Health, Aging, and Body ...
Kiviniemi Antti M AM Department of Exercise and Medical Physiology, Verve Research, Oulu, Finland. Electronic address: - - 2014
Depressed baroreflex sensitivity (BRS) is associated with an increased risk of mortality in patients with a known cardiac disease. The prognostic significance of BRS in subjects without history of major cardiovascular (CV) events is unknown. The present study tested the hypothesis that impaired BRS predicts the CV mortality in a ...
Espinha Lívia P LP Department of Animal Morphology and Physiology, São Paulo State University - (UNESP FCAV), Jaboticabal, SP, Brazil; National Institute of Science and Technology in Comparative Physiology (INCT-FisiologiaComparada), - - 2014
Pulmonary ventilation (V⋅E), body temperature (Tb), mean arterial pressure (MAP), heart rate (fH) and metabolic rate [Formula: see text] were measured in 10 (d10)- and 21 (d21)-day-old male and female chicks exposed to 7% CO2. Under normocapnia, V⋅E was higher in d10 chicks than in d21 due to a higher ...
Yang Ai Min AM College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000, Gansu, China; School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, - - 2014
The prevalence of metabolic syndrome (MS) was investigated in Chinese nickel-exposed workers. A total of 35 104 subjects were enrolled in this study. The age-adjusted prevalence of MS, BMI⋝25, diabetes, hypertension, and abnormal lipid was 13.9%, 29.5%, 12.8%, 27.5%, and 47.1%, respectively. The prevalence of BMI⋝25, hyperglycemia, and hypertension increased ...
Li Pingyue - - 2014
Three-dimensional knee models of 148 Chinese (61 males, 87 female) and of 127 Caucasian (79 male, 48 female) were constructed. The anteroposterior (fAP, tAP) and mediolateral (fML, tML) dimensions of cross-section of the femur and tibia after simulated TKA bony resection were measured. Females have smaller femoral aspect ratios (fML/fAP) ...
Waade Ragnhild Birkeland RB Center for Psychopharmacology, Diakonhjemmet Hospital, PO Box 85 Vinderen, 0319, Oslo, Norway, - - 2014
The aim of the present study was to investigate the effect of age on venlafaxine and escitalopram serum concentrations in various cytochrome P450 (CYP) 2D6 and CYP2C19 genotype subgroups. Serum concentration measurements from CYP-genotyped patients treated with venlafaxine (n = 255) or escitalopram (n = 541) were collected retrospectively from a therapeutic drug monitoring ...
Kent Dennis V DV Department of Earth and Planetary Sciences, Rutgers University, Piscataway, NJ 08854;Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY 10964; - - 2014
A measured magnetozone sequence defined by 24 sampling sites with normal polarity and 28 sites with reverse polarity characteristic magnetizations was established for the heretofore poorly age-constrained Los Colorados Formation and its dinosaur-bearing vertebrate fauna in the Ischigualasto-Villa Union continental rift basin of Argentina. The polarity pattern in this ∼600-m-thick ...
Barakat Neveen H NH University of California San Diego (UC San Diego), Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, - - 2014
Hydrocodone combined with acetaminophen is commonly used for moderate pain. Hydrocodone is metabolized by cytochrome P450 (CYP) 2D6 into hydromorphone and by CYP3A4 into norhydrocodone. This was a retrospective study evaluating hydrocodone, hydromorphone and norhydrocodone distributions in urine. Urine specimens (n = 76,924) were obtained from patients on chronic opioid ...
Perciavalle Valentina V 1 Department of Sciences of Formation, University of - - 2014
Summary.-The main purpose of the present investigation of 21 elite male swimmers was to assess whether the Ape Index (the ratio between the individual's arm span and height) and/or the second-to-fourth digit length ratio (2D:4D), i.e., the ratio between the length of the second and the fourth fingers of the ...
Bailey Jeannie F JF Depts. of Anthropology and Orthopaedics & Sports Medicine, University of Washington, Seattle, WA; Dept. of Orthopaedic Surgery, University of California, San Francisco, CA; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, Poolesville, MD. Electronic address: - - 2014
To compare gross and histologic patterns of age-related degeneration within the intervertebral disc and adjacent vertebra between rhesus monkeys and humans. We examined age-related patterns of disc degeneration from mid-sagittal sections of the intervertebral disc and adjacent vertebral bodies among six rhesus monkey thoracolumbar and seven human lumbar spines. Gross ...
Martins Clarissa S CS Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, - - 2014
The GHR polymorphisms contribution to the interindividual variability in prenatal and postnatal growth as well as to metabolic traits is controversial. The aim of this study is to analyze the association of the GHRfl/d3 polymorphism with prenatal and postnatal growth and metabolic outcomes in adult life and to compare the ...
Cena H H Department of Public Health, Experimental and Forensic Medicine - Unit of Human Nutrition, University of Pavia, Pavia, - - 2014
Obese adolescents with high proportion of visceral fat are at higher risk of developing the metabolic syndrome. The study aims to investigate if echocardiographic epicardial fat thickness (EF) could be predictive of visceral obesity (VO) early in life and to provide EF threshold values specific for male adolescents. Further aim ...
Weiss Lindsay M LM University of Connecticut School of - - 2014
Early onset drug use is associated with increased risk of developing substance use disorders, but relatively little is known about the correlates of early drug use among adults receiving treatment. A retrospective analysis of a randomized study of contingency management treatment compared cocaine-dependent patients who reported initial cocaine use at ...
Cavallari Larisa H - - 2014
To the Editor: Three articles in the December 12 issue(1)-(3) address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know ...
Pereira Naveen L - - 2014
To the Editor: Three articles in the December 12 issue(1)-(3) address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know ...
Schwarz Ute I - - 2014
To the Editor: Three articles in the December 12 issue(1)-(3) address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know ...
Koller Elizabeth A - - 2014
To the Editor: Three articles in the December 12 issue(1)-(3) address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know ...
- - 2014
To the Editor: Three articles in the December 12 issue(1)-(3) address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know ...
Yin Xue Yao XY Department of Endocrinology, Sir Run Run Shaw Hospital, Affiliated to School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, - - 2014
Central obesity is considered to be a central component of metabolic syndrome. Waist circumference (WC) has been widely used as a simple indicator of central obesity. This study is aimed to evaluate the sensitivity of WC cut-off values for predicting metabolic risk factors in middle-aged Chinese. The study involved 923 ...
Rajput Rajesh R Department of Endocrinology and Medicine Unit VI, Pt. B.D.S. PGIMS, Rohtak, Haryana, - - 2014
To compare waist circumference (WC), body mass index (BMI), waist hip ratio (WHR), and waist-to-height ratio (WHtR) and define an appropriate cut-off, which is most closely predictive of the non-adipose components of the IDF metabolic syndrome (MetS) definition. A total of 3,042 adults (1,693 in rural area and 1,349 in ...
Pathania Deepak D Department of Community Medicine, MMIMSR, Mullana, Haryana, - - 2014
Metabolic syndrome (MS) is a state of deranged metabolic and anthropometric status. It is considered a precursor to various cardiovascular and metabolic diseases. (1) To determine the prevalence of MS in adults aged 20 years and above in the rural area of Ambala district, Haryana. (2) To determine the sociodemographic ...
Mora Mireia M Department of Endocrinology and Nutrition, Hospital Clínic i Universitari of Barcelona, Barcelona, - - 2014
Ageing is a physiological process that may be influenced by genetic factors as well as metabolic and hormonal determinants. The aim was to describe metabolic and hormonal factors related to survival in the cohort of non-institutionalized people aged >70 years old of the Mataró Ageing Study. 313 individuals were included ...
Bove R R Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Brookline, MA, - - 2014
Gonadal steroids may modulate disease course in multiple sclerosis (MS). To assess the prevalence and clinical associations of hypogonadism in men with MS. Male patients, aged 18-65 years, with relapsing-remitting MS (RRMS) or clinically-isolated syndrome (CIS) and their first symptom < 10 years prior were selected from a longitudinal clinical ...
Markatseli Anastasia E AE Department of Endocrinology, University of Ioannina, 45110 Ioannina, - - 2014
To assess the potential association of the pentanucleotide (TAAAA)n repeat polymorphism in the promoter of SHBG gene with the age at menopause in a Greek female population. Cross-sectional study. Two hundred and ten postmenopausal women aged 46-63 years were enrolled. The age at the last menstrual period and anthropometric parameters ...
Kunnoor N S NS Department of Pharmacology, St John's Medical College, Bangalore 560034, Karnataka, India. - - 2014
This study aimed to examine age- and gender-related differences in the comorbidities, drug utilisation and adverse drug reaction (ADR) patterns of patients admitted to a coronary care unit (CCU). The present study was a retrospective cohort study. Two trained physicians independently reviewed the case records of CCU patients over a ...
Gupta S S Department of Oral Pathology, King George's Medical University, Lucknow, Uttar Pradesh, - - 2014
The aim of the study to find out role of CYP2E1 genetic polymorphism in development of oral leukoplakia among tobacco users in North Indian population, this study was carried out at Department of Oral and Maxillofacial Pathology, King George's Medical University, Lucknow, UP. Study include a total of 105 leukoplakia ...
Celojevic Dragana D Department of Clinical Neuroscience and Rehabilitation/Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg , Gothenburg , Sweden - - 2014
Abstract Background: Ephrin receptors (Ephs) are tyrosine kinases that together with their ligands, ephrins, are considered important in cell-cell communication, especially during embryogenesis but also for epithelium homeostasis. Studies have demonstrated the involvement of mutations or common variants of the gene encoding Eph receptor A2 (EPHA2), in congenital cataract and ...
Koyanagi Takashi T Ono Pharmaceutical Co., Ltd., Mishima-gun , Osaka , Japan - - 2014
Abstract 1.  The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in cynomolgus monkeys (3-18 years old) and beagle dogs (2-11 ...
Schrack Jennifer A JA Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, - - 2014
To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults. Cross-sectional analysis. Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (BLSA). Persons aged 40 to 96 (mean 68.2 ± 11.0) who underwent a comprehensive physical examination, cognitive assessment, RMR testing, body ...
Tackney Justin J Department of Anthropology, University of Utah, Salt Lake City, Utah, - - 2014
Slower rates of aging distinguish humans from our nearest living cousins. Chimpanzees rarely survive their forties while large fractions of women are postmenopausal even in high-mortality hunter-gatherer populations. Cellular and molecular mechanisms for these somatic aging differences remain to be identified, though telomeres might play a role. To find out, ...
McComb Karen K Mammal Vocal Communication and Cognition Research, School of Psychology, University of Sussex, Brighton BN1 9QH, United - - 2014
Animals can accrue direct fitness benefits by accurately classifying predatory threat according to the species of predator and the magnitude of risk associated with an encounter. Human predators present a particularly interesting cognitive challenge, as it is typically the case that different human subgroups pose radically different levels of danger ...
Peters Erica N EN From the Friends Research Institute (ENP, FJV), Baltimore, MD; Yale University School of Medicine (ENP), New Haven, CT; Department of Health Behavior (PSH), University of Alabama at Birmingham School of Public Health, Birmingham, AL; and Department of Psychiatry and Behavioral Neurobiology (CBC, KLC), The University of Alabama at Birmingham, Birmingham, - - 2014
African American youth who use marijuana are less likely to attend and complete treatment than white youth. Limited information is available on racial and age variation in treatment attendance and completion among adults who use marijuana. The current research examined differences in community-based substance abuse treatment attendance and completion between ...
Kempinska-Podhorodecka Agnieszka A Medical Biology Laboratory Pomeranian Medical University, Szczecin, Poland. - - 2014
The common PNPLA3 (adiponutrin) variant p.I148M represents a major genetic driver of progression in non-alcoholic fatty liver disease (NAFLD). NAFLD is commonly associated with traits of the metabolic syndrome, therefore it is mostly suspected in obese individuals. Here, we investigate the association between the PNPLA3 variant and anthropometric traits in ...
Rabkin Simon W SW Department of Medicine (Cardiology), University of British Columbia, 9th Floor 2775 Laurel St., Vancouver, B.C., V5Z 1M9, - - 2014
To explore the effect of aging on cardiac toxicity specifically the interaction of age and antipsychotic drugs to alter the QT interval. THE MEDLINE DATABASES WERE SEARCHED USING THE OVIDSP PLATFORMS WITH THE SEARCH STRATEGY: "QT interval" or "QT" and "age" or "aging". The entry criteria were: over 10,000 apparently ...
Zhao Jinying J Department of Epidemiology, Tulane University School of Public Health, New Orleans, LA 70112; - - 2014
Short telomere length, a marker of biological aging, has been associated with age-related metabolic disorders. Telomere attrition induces profound metabolic dysfunction in animal models, but no study has examined the metabolome of telomeric aging in human. Here we studied 423 apparently healthy American Indians participating in the Strong Family Heart ...
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