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Sanders Yvonne V YV Department of Hematology, Erasmus University Medical Center, Rotterdam, The - - 2014
Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related differences in bleeding phenotype between elderly VWD patients and those ...
Sartorius Gideon A GA Andrology Department, Concord Hospital, Sydney, NSW, Australia; ANZAC Research Institute, University of Sydney, Sydney, NSW, - - 2014
Male sexual function is highly androgen dependent but whether aromatization of testosterone (T) to estradiol is required remains contentious. This study aims to investigate the effects of selective estrogen deficiency induced by a nonaromatizable androgen, dihydrotestosterone (DHT), on sexual function of healthy middle-aged and older men. Randomized clinical trial of ...
Hernandez Maria Isabel - - 2014
Prepubertal hypertrichosis is a reportedly benign condition characterized by an excessive growth of vellous hair in non-androgen dependent areas of the body compared to the amount usually present in normal subjects of the same age, race and sex. Although this condition is usually considered idiopathic and regarded as benign, it ...
Cui Yuqian Y Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University; National Research Center for Assisted Reproductive Technology and Reproductive Genetics; Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of - - 2014
To determine the serum antimüllerian hormone (AMH) reference values in Chinese women with and without polycystic ovary syndrome (PCOS), and the associations of AMH with clinical or biochemical characteristics. Retrospective study. Academic institutions. Totals of 1,896 infertile control women and 304 women with PCOS. None. Serum basal AMH levels and ...
Ress Krista K Department of Immunology, Institute of Bio- and Translational Medicine and Centre of Excellence for Translational Medicine, University of Tartu, Tartu, - - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin disease that can be classified into an extrinsic or intrinsic type. A high percentage of patients, especially adults with the extrinsic type of AD, have been reported to show antibodies to antinuclear proteins (ANA). We aimed to study the prevalence of ANA ...
Ahern T T Weight Management Service (T.A., A.K., E.O., C.D., C.W., D.O.), St Columcille's Hospital, Loughlinstown, County Dublin, Ireland; Obesity Research Group, Education and Research Centre (T.A., A.K., C.W., D.O.), Department of Endocrinology (T.A., A.K., C.W., M.J.M., D.O.), and Metabolism Laboratory (M.K., M.J.M.), St Vincent's University Hospital, Elm Park, Dublin 4, - - 2014
Context: Mortality is 85% higher in severely obese subjects (body mass index [BMI] > 40 kg/m(2)) than in subjects with a healthy BMI; poor physical function may be contributory. Hypovitaminosis D is common in obese subjects and is associated with physical dysfunction in the elderly. Objective: We determined the relationship ...
Keller Erica E Department of Obstetrics and - - 2014
Metabolic characteristics of PCOS women and PCOS-like, prenatally androgenized (PA) female monkeys worsen with age, with altered adipogenesis of subcutaneous (SC) abdominal adipose potentially contributing to age-related adverse effects on metabolism. This study examines whether adipocyte morphology and gene expression in SC abdominal adipose differ between late reproductive-aged PA female ...
Takahashi Haruhiko H Department of Gastroenterology, Fukuoka University Chikushi - - 2014
The prevalence of ulcerative colitis (UC) is increasing steadily in Japan. In Western countries, a bimodal distribution, with UC onset peaks in youth and middle age, is observed, and smoking cessation is reported as a risk factor for UC. However, there are few reports on a bimodal distribution of onset ...
Lewerin Catharina C Section of Hematology and Coagulation, Department of Internal Medicine, at the Institute of Medicine (C.L, H.N-E.), Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Clinical Chemistry and Transfusion Medicine (S.J.), Sahlgrenska Academy at the University of Gothenburg, Sweden; Center for Bone and Arthritis Research (CBAR) (H.J., V.S., M.L., D.M.) Geriatric Medicine at the Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Sweden; Clinical and Molecular Osteoporosis Research Unit (M.K.K.), Department of Clinical Sciences and Orthopaedics, Lund University, Malmö, Sweden; Department of Family and Preventative Medicine (E.B-C.), University of California, San Diego, USA; Center for Bone and Arthritis Research (CBAR) (L.V., C.O.) Department of Internal Medicine, at the Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, - - 2014
Context: Blood hemoglobin (Hb) declines with age in healthy elderly men, in whom decreasing testosterone has been regarded as part of normal ageing. However, the association between Hb and serum estradiol is incompletely known. Objective: To determine whether estradiol is associated with anemia/Hb and established determinants of Hb in elderly ...
O'Toole Aoibhlinn A Centre for Colorectal Diseases, St Vincent's University Hospital/University College Dublin (SVUH) , Elm Park, Dublin 4 , - - 2014
Abstract Objective. To assess mortality in inflammatory bowel disease (IBD) patients under 65 years of age and to identify the factors related to death in this age group. Methods. We studied 2570 IBD patients who were diagnosed as having disease before 65 years of age and attended a single tertiary ...
Tehrani F R - - 2014
ABSTRACT Objective: Despite the wide use of anti-Mullerian hormone (AMH) measurement as a clinical marker for assessment of ovarian reserve, a population based estimate for its reference valuesis not available. In this study we have estimated age-specific AMH levels in a large sample of fertile women directly selected from a ...
Caro Xavier J XJ Northridge Hospital Medical Center, Professional Building, 18350 Roscoe Boulevard, Suite 418, Northridge, CA, - - 2014
Objective. A subset of fibromyalgia (FM) patients exhibits a large fiber, demyelinating peripheral polyneuropathy, akin to that seen in chronic inflammatory demyelinating polyneuropathy (CIDP). It has been suggested that this demyelinating process is likely to be immune mediated. Since it is known that similar, large fiber neuropathic lesions may be ...
McQuaid Fiona F 1Oxford Vaccine Group Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom 2Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom 3Novartis Vaccines and Diagnostics S.r.l. Siena, Italy 4Novartis Vaccines and Diagnostics, Inc. Cambridge - - 2014
A serogroup B meningococcal vaccine (4CMenB) has been licensed by the European commission for use in various infant schedules. However, data are limited on persistence of serum bactericidal antibodies (SBA), which is necessary to inform cost-effectiveness analysis. Sera were obtained from three groups of 5 year-old children previously immunized at ...
Fallah M M Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, - - 2014
Increased risk of Hodgkin lymphoma (HL) associated with personal history of several autoimmune diseases (ADs), such as rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, and immune thrombocytopenic purpura, are known. Whether there are other HL-related ADs and whether the increased risk of HL after ADs holds across sex, age, year of ...
Kim Ha Yeon HY Department of Internal Medicine, Chonnam National University Medical School, Gwangju, - - 2014
Background/Aims: Blood pressure (BP) variability is known as a poor prognostic factor for cardiovascular outcomes. This study assessed the prognostic significance of BP variability in association with increasing age in hemodialysis patients. Methods : We retrospectively analyzed 2,174 patients on hemodialysis from March 2005 to December 2012. The impact of ...
Uçar Ahmet A Istanbul University, Istanbul Faculty of Medicine, Department of Paediatrics, Division of Growth-Development, Paediatric Endocrinology and - - 2014
Context: The causes of polycystic ovarian syndrome (PCOS) in girls with precocious adrenarche (PA) remain unclear. Objective: The goal was to compare the clinical, biochemical, and ultrasound characteristics of girls with PA whose size at birth was appropriate for gestational age (AGA) vs. those born small for gestational age (SGA). ...
Wang Ligong L Department of Radiology, Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Center for Biomedical Imaging, New York University Langone Medical Center, 660 First Avenue, 4th Floor, New York, NY 10016; School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu Province, China; School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu Province 215123, China. Electronic address: - - 2014
The objectives of this study were to investigate the changes in compartment-specific subchondral bone marrow lipids of femoral-tibial bone in acute anterior cruciate ligament (ACL)-injured patients compared to that of healthy volunteers and patients with osteoarthritis (OA) (Kellgren-Lawrence [KL] grade 2-3). A total of 55 subjects were recruited in the ...
Downes Kevin J KJ Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: - - 2014
The epidemiology of aminoglycoside-associated acute kidney injury (AG-AKI) has not been well described in pediatric patients with cystic fibrosis (CF). We aimed to assess the impact of daily serum creatinine (SCr) measurement on detection of AG-AKI at our institution. We examined a cohort of hospitalized patients with CF who received ...
Knipping Karen K Nutricia Research, Utrecht, The Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The - - 2014
Eosinophilic oesophagitis (EO) is an emerging worldwide disease, closely associated with male gender and allergic disorders. This study investigated the distribution of allergy markers in a cohort of children with EO. We analysed allergy markers in 91 children (62 males and 29 females) with EO and a control group of ...
Brick Katherine E KE Department of Dermatology, Mayo - - 2014
Bullous pemphigoid (BP) is an autoimmune blistering disease that is associated with increased mortality. We sought to determine the incidence and mortality of patients with BP. A total of 87 residents of Olmsted County, Minnesota, were identified who had their first lifetime diagnosis of BP from January 1960 through December ...
Giagulli V A VA Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy, - - 2014
This study examined whether the AR-CAG repeat length might affect clinical characteristics (testis volume) seminal parameters (sperm count and its mobility) along with hormonal serum profile [FSH, LH, Testosterone (T) and Inhibin B (InhB)] both in idiopathic male infertility (IM) and in infertility due to a previous condition of cryptorchidism ...
Zawadka-Kunikowska Monika M Department of Hygiene and Epidemiology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. M. Sklodowskiej-Curie 9, 85-094, Bydgoszcz, Poland, - - 2014
This study objectively analyzed postural instability and cognitive function in patients with Parkinson's disease (PD) and a group of healthy elderly and middle-aged individuals. The study included ten healthy middle-aged individuals (range 42-57 years), 14 healthy elderly individuals (range 60-90 years) and 15 PD patients (range 58-93 years). Center of pressure (COP) parameters ...
Krogenæs Anette - - 2014
Canine herpesvirus-1 (CHV1) causes a fatal hemorrhagic disease in neonatal puppies and is associated with infertility in female dogs. This study was conducted to assess the status of CHV1 infection in bitches in proestrus or estrus and to investigate possible risk factors by a detailed questionnaire. Blood samples were collected ...
Zahedifard Sara S Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. MBL deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), and is associated with predisposition to infections ...
Lee Jessica J JJ *Division of Gastroenterology and Nutrition †Clinical Research Center, Design and Analysis Core ‡Division of Endocrinology, Boston Children's Hospital, Boston, - - 2014
In this pilot study, we analyzed serum insulin-like growth factor 1 (IGF-1)- and IGF-binding protein-3-for-age z scores from 54 inflammatory bowel disease children with no, temporary, or permanent growth impairment. Although our findings did not reach statistical significance, patients with permanent linear growth impairment had lower IGF-1-for-age z scores (-1.76 ...
Karthikeyan Ramaraju R Department of Respiratory Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, - - 2014
Recent research using serum high sensitivity C-reactive protein (hs-CRP) has evidenced existence of low grade systemic inflammation in asthmatics whose correlation with various clinical indices is not fully studied. To investigate the relationship between systemic inflammation and various clinical and treatment characteristics of asthma. Forty asthmatics (22 steroid inhaling and ...
Rembach Alan A The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. - - 2014
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc ...
Fox Deborah J DJ 1New York State Department of Health, Albany, NY, - - 2014
This study examines trends in corticosteroid use for males with Duchenne muscular dystrophy by birth year, race/ethnicity, and knowledge of Duchenne muscular dystrophy family history. Firstborn males (n = 521) selected from a population-based surveillance system of Duchenne muscular dystrophy were analyzed using Kaplan Meier and regression methods. Comparing males ...
Fromm Annette - - 2014
Vascular morbidity and mortality due to cardiovascular disease (CVD) are high after ischemic stroke at a young age. Data on carotid intima-media thickness (cIMT) as marker of atherosclerosis are scarce for young stroke populations. In this prospective case-control study, we examined cIMT, the burden of vascular risk factors (RF) and ...
Renvert Stefan S Oral Health Sciences, University of Kristianstad, Kristianstad, 29188, Sweden, - - 2014
This study aims to assess mortality risk and its association to health aspects in dentate individuals 60 years of age and older. Medical and periodontal data from 870 dentate individuals (age range 60-96) participating in the Swedish National Study on Aging and Care in Blekinge (SNAC-Blekinge) with survival statistics over 6 years ...
Newson R B RB Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, - - 2014
Geographical variation in the prevalence of sensitization to aeroallergens may reflect differences in exposure to risk factors such as having older siblings, being raised on a farm or other unidentified exposures. We wanted to measure geographical variation in skin prick test positivity and assess whether it was explained by differences ...
Joung Kyoung Eun KE Division of Newborn Medicine (K.E.J.), Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Beth Israel Deaconess Medical Center, and Harvard Medical School (K.E.J., C.S.M.), Boston, Massachusetts 02215; Department of Family Medicine (K.-H.P.), Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do 431-070, Korea; Section of Endocrinology (L.Z., A.S.-E., B.T., M.B., C.S.M.), Division of Endocrinology, Boston Veterans Affairs Healthcare System, Jamaica Plain, Massachusetts 02130; Section of Endocrinology, Diabetes, and Nutrition (A.S.-E., B.T., C.S.M.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118; Judge Baker Children's Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120; and Department of Psychiatry and Behavioral Sciences (J.A.C.), Stony Brook University School of Medicine, Stony Brook, New York - - 2014
Context: Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other ...
Nøst Therese Haugdahl TH Department of Environmental Chemistry, NILU - Norwegian Institute for Air Research, Fram Centre, Hjalmar Johansens Gate 14, NO-9296 Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Sykehusveien 44, NO-9037 Tromsø, Norway; Department of Laboratory Medicine, Diagnostic Clinic, University Hospital of North Norway, Sykehusveien 38, NO-9038 Tromsø, Norway. Electronic address: - - 2014
Longitudinal biomonitoring studies can provide unique information on how human concentrations change over time, but have so far not been conducted for per- and polyfluoroalkyl substances (PFASs) in a background exposed population. The objectives of this study were to determine: i) serum PFAS time trends on an individual level; ii) ...
Shi Anna J - - 2014
Abstract Background: Since patients with cystic fibrosis (CF) are living longer, chronic malabsorption of carotenoids associated with CF resulting in decreased macular pigment may affect macular long-term health in later life pathology. This study compared the macular pigment optical density (MPOD) and corresponding central macular volume (MV) of adult CF ...
Ollandini G G Department of Urology, University of Trieste, Trieste, - - 2014
We reviewed a large number of patients from 2000 to 2010 that underwent varicocoele correction using the retrograde sclerotization approach. Three hundred and seventy-six of them were included in the study, as they met the inclusion criteria. Mean age at the time of surgery was 32 years (SD: 6.5); 32% of ...
Mottalib Md Abdul - - 2014
Here, we report the phase distribution of chronic myeloid leukemia (CML), defined based on the World Health Organization criteria, among 63 patients in Bangladesh. All patients were diagnosed based on complete blood count, bone marrow examination including bone marrow aspiration and reverse-transcriptase polymerase chain reaction (RT-PCR). Out of 63 patients, ...
Neelam Kumari K Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, 90 Yishun Central, Yishun, Singapore, 768828, - - 2014
Purpose: To examine the spatial profile of macular pigment (MP) and its relationship with serum concentrations of lutein (L) and zeaxanthin (Z) in subjects from a Singapore Chinese population. Methods: In this cross-sectional study, the following details were recorded in 95 healthy subjects: sociodemographic, life style information, body mass index ...
Bammer C C Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, - - 2014
Myelodysplastic syndromes (MDS) are typical diseases of the elderly. The clinical outcome of a well-characterized cohort of patients with MDS was analyzed for prevalence and impact of comorbidities to establish the basis for tailored treatment algorithms. Focus was on age- and sex-related differences. The hematopoietic cell transplantation-comorbidity index (HCT-CI) was ...
Farag Youssef Mk - - 2014
Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. 6120 subjects participated in the Screening and Early Evaluation of Kidney disease (SEEK), a community-based screening program in 53 camps in ...
Zosky Graeme R GR University of Tasmania, School of Medicine, Hobart, Tasmania, Australia, University of Western Australia, Telethon Institute for Child Health Research, Subiaco, Australia ; - - 2014
Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency ...
Chin Kok-Yong KY Department of Pharmacology - - 2014
Abstract Objective: The role of insulin-like growth factor-1 (IGF-1) in bone health in men is debatable. This study aimed to determine whether IGF-1 is a mediator in age-related decline of bone health status measured by calcaneal speed of sound (SOS) in Malaysian men. Methods: The study recruited 279 Chinese and ...
Chung Min-Shen MS Division of Metabolism, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung, 833, - - 2014
To evaluate the correlates of nocturia and subsequent mortality in patients with type 2 diabetes mellitus (T2DM). A self-administered questionnaire containing overactive bladder symptom score was obtained from subjects with T2DM. Nocturia and severe nocturia were defined as rising ≥2 or ≥3 per night to void, respectively. Patient characteristics and ...
Fossati Nicola N Department of Urology, San Raffaele Turro, Vita-Salute San Raffaele University, Milan, - - 2014
To test the hypothesis that [-2]proPSA (p2PSA) and its derivates are more accurate than total-PSA (tPSA), free-PSA (fPSA) and percentage of fPSA to tPSA (%fPSA) in detecting prostate cancer (PCa) in men younger than 60 years. The analysis consisted of a nested case-control study from the PRO-psa Multicentric European Study ...
Wisse Laura E M LE Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, the - - 2014
We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic resonance imaging in 16 ...
Zheng Zhenzhen Z Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, - - 2014
Oxidative stress is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Serum uric acid (UA) has anti-oxidative effect. To clarify the associations between UA and sporadic ALS (SALS) in Chinese population. A total of 512 SALS patients and 501 age- and gender- matched healthy controls were included, with fasting ...
Honkalampi Kirsi K Department of Education and Psychology, University of Eastern Finland, Joensuu, - - 2014
Objectives: Clinical studies have demonstrated that circulating cytokine profiles may differ between alexithymic and non-alexithymic subjects. We examined whether the levels of adiponectin (μg/ml) and resistin (ng/ml) are independently related to alexithymic features in a population-based sample. Methods: In 2005, clinical data including laboratory assessments were obtained from a sub-sample ...
Harris Julia G JG Children's Hospital of Wisconsin, Milwaukee, - - 2014
Systemic lupus erythematosus (SLE) can lead to significant morbidity and mortality related to coronary artery disease. Obesity is an additional risk factor for cardiovascular disease that appears to be more prevalent in this population. Obesity in SLE has been linked to decreased health-related quality of life, functional limitations, pain, fatigue, ...
Artemiadis Artemios K AK Department of Neurology, 417 Army Share Fund - - 2014
Aims. To investigate the role of centrally recorded P300 in patients suffering from mesial temporal sclerosis-temporal lobe epilepsy (MTS-TLE). Methods. Sixteen patients (3 men and 13 women; median age: 32.5 years old) suffering from TLE with MTS and 43 healthy controls (12 men and 31 women; median age: 35 years ...
Thuesen Betina H BH Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, - - 2014
Besides the important skeletal functions, it has been suggested that vitamin D is involved in the pathogenesis of allergy and asthma and related to lung function. However, previous studies are inconclusive. The purpose of this study was to investigate associations of serum levels of 25-hydroxy vitamin D (25(OH)D) with atopy, ...
van Schoor N M NM Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands, - - 2014
Vitamin D levels remained fairly stable during ageing with increasing levels in persons aged 55-65 years old and decreasing levels in persons aged 65-88 years old. The seasonal variation was larger than the longitudinal change. Our findings implicate that vitamin D supplementation becomes more important in older age groups and during wintertime. ...
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