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Silva Silvana Marques E SM Coloproctology Service, University Hospital of Brasília, Brasília University, Brasília, DF, - - 2014
Colorectal cancer is a major cause of morbidity and mortality and can arise through the adenoma-carcinoma sequence. Colonoscopy is considered the method of choice for population-wide cancer screening. To assess the characteristics of endoscopically resected polyps in a consecutive series of patients who underwent colonoscopy at a university hospital and ...
Cunha F S FS Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, - - 2014
Male-to-female transsexual persons use oestrogens + antiandrogens to adapt their physical bodies to the female sex. Doses are usually somewhat higher than those used by hypogonadal women receiving oestrogen replacement. Particularly in cases of self-adminstration of cross-sex hormones, doses may be very high. Oestrogens are powerful stimulators of synthesis and release of ...
Ring Margareta M 1] Section of Clinical Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden [2] Department of Clinical Physiology, Karolinska University Hospital, Karolinska University Hospital, Stockholm, - - 2014
Arterial stiffness is an important cardiovascular risk marker, which can be measured noninvasively with different techniques. To validate such techniques in healthy subjects, we compared the recently introduced oscillometric Arteriograph (AG) technique with the tonometric SphygmoCor (SC) method and their associations with carotid ultrasound measures and traditional risk indicators. Sixty-three ...
Pinola P P Department of Obstetrics and Gynaecology, Oulu University Hospital, University of Oulu and Medical Research Center Oulu, Oulu, - - 2014
Can serum anti-Müllerian hormone (AMH) levels measured in female adolescents predict polycystic ovary syndrome (PCOS)-associated features in adolescence and early adulthood? AMH levels associated well with PCOS-associated features (such as testosterone levels and oligoamenorrhoea) in adolescence, but was not an ideal marker to predict PCOS-associated features in early adulthood. Several ...
- - 2014
An estimated 1.3 million people over the age of 65 are believed to be malnourished in the UK.
Graffe Alix A Ophthalmology, Angers University Hospital, Angers, 49933, - - 2014
Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% ...
Kiuru Eveliina E Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, - - 2014
Background: The impact of the age and sex adjusted body mass index (ISO-BMI) in the obese vs. non-obese children and adolescents with cholecystectomy for cholelithias is rarely reported. Patients and Methods: The national database was searched for cholecystectomies performed in paediatric patients between 1997 and 2011, and the 59 paediatric ...
Kitano Naomi N Department of Public Health, School of Medicine, Wakayama Medical - - 2014
Background: To clarify the contribution of patient age to the development of coronary artery lesions (CALs) associated with Kawasaki disease (KD), epidemiologic features and prognostic factors were investigated using hospital-based complete enumeration surveys in a specific area.Methods: Consecutive KD cases identified between October 1999 and September 2012 in Wakayama Prefecture, ...
Forbes Michael M Department of Pediatrics; Akron Children's Hospital; Akron, OH - - 2014
Monthly doses of palivizumab, an RSV-specific monoclonal antibody, reduce RSV-related hospitalizations (RSVH) in high-risk children; however, no specific palivizumab level has been correlated with disease severity in humans. A post hoc analysis of a previous randomized, placebo-controlled trial evaluated the relationship between serum palivizumab level at the time of RSVH ...
Kessler Jeffrey I JI Kaiser Permanente Southern California, Los Angeles, California, USA - - 2014
Osteochondritis dissecans (OCD) of the ankle is a disorder of the talar or distal tibial subchondral bone and articular cartilage whose incidence in children is not clearly known. To assess the demographics and epidemiology of OCD of the ankle in children. Descriptive epidemiologic study. A retrospective chart review of an ...
Cicero Arrigo Francesco Giuseppe AF Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy, - - 2014
Contrasting evidence shows a possible association between serum uric acid (SUA) and cognitive function in elderly subjects. We aimed at evaluating the impact of circulating SUA levels on cognitive function in a cohort of pharmacologically untreated young elderly subjects. For this study, we selected 288 healthy young elderly participants from ...
Xie Liang L Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Institute of Neuroscience, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, - - 2014
The cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research. Although living conditions affect behavioral and physiological characteristics in macaques, little data is available on how living conditions influence blood-based parameters in the cynomolgus monkey. We hypothesize that there are significant differences in serum biochemical and hematological parameters ...
Herrick Kirsten A - - 2014
Data from the National Health and Nutrition Examination Survey (NHANES) and the NHANES National Youth Fitness Survey, 2012. Nearly all (98.5%) youth aged 12-15 reported watching TV daily. More than 9 in 10 (91.1%) youth aged 12-15 reported using the computer daily outside of school. In 2012, 27.0% of youth ...
Mustafa Mahmoud M Urology Department, School of Medicine and Health Science, An-Najah University, Nablus, West-Bank, - - 2014
To evaluate the relationship between levels of total testosterone and total prostate-specific antigen (PSA) in healthy men with PSA<4 ng/mL. The study comprised 179 men with a mean age of 59.19±12 years who visited Osmaniye State Hospital, Osmaniye, Turkey, between January 2006 and January 2007 for a routine checkup. The ...
Saad Farid F Bayer Pharma, Global Medical Affairs Andrology, Berlin, Germany; Gulf Medical University School of Medicine, Ajman, UAE. Electronic address: - - 2014
Some men between the ages 45 and 60 years develop complaints and symptoms reminiscent of menopausal complaints in women. So, parallels were sought between the changes in female and male endocrinology during that period of life. Indeed, men do show a decline of serum testosterone from age 40 to 50 ...
Toms L-M L LM School of Clinical Sciences and Institute for Health and Biomedical Innovation, Queensland University of Technology, Gardens Point, Brisbane 4001, Australia. Electronic address: - - 2014
Some perfluoroalkyl and polyfluoroalkyl substances (PFASs) have become widespread pollutants detected in human and wildlife samples worldwide. The main objective of this study was to assess temporal trends of PFAS concentrations in human blood in Australia over the last decade (2002-2011), taking into consideration age and sex trends. Pooled human ...
Søeborg Tue T Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: - - 2014
The influence of sex, age, pubertal development and oral contraceptives on dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), testosterone (T), calculated free testosterone (fT), free androgen index (FAI) and selected ratios in 1798 serum samples from healthy children, adolescents and young adults was evaluated. Samples were analyzed by ...
Altara R R Maastricht University, Department of Pharmacology, Maastricht, - - 2014
Heart failure is a condition associated with high morbidity and mortality. Our current pharmacotherapeutic interventions can at best slow down the progression of the disease. At present, a proper molecular characterization of the disease process is lacking. Biomarkers that provides insight into the molecular mechanisms underlying the malfunctioning of the ...
Chen Ning-Yuan - - 2014
Variants in Methylenetetrahydrofolate reductase (MTHFR) gene may result in a lowered catalytic activity and associate with subsequent elevated serum homocysteine (Hcy) concentration, abnormal DNA synthesis and methylation, cardiovascular risk, and unhealthy aging. Several investigations on the relationship of MTHFR C677T polymorphism with serum lipid profile and longevity have been conducted ...
Perna Laura L Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, - - 2014
Background/Aims: Very few studies have investigated the longitudinal association between serum levels of 25-hydroxyvitamin D [25(OH)D] and cognitive impairment not due to dementia. This longitudinal study analysed 25(OH)D and the risk of cognitive decline among non-demented older adults. Methods: A subsample of the ESTHER cohort study, aged ≥70 years, was ...
Rodriguez-Merchan Emerito Carlos EC Department of Orthopaedic Surgery, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, - - 2014
Radiosynovectomy (RS) is the best choice for patients with persistent synovitis of the knee unresponsive to a 3-month trial of prophylactic factor replacement. If three consecutive RSs with 6-month intervals have been ineffective, an arthroscopic synovectomy should be indicated in patients older than 12 years of age (adolescents). In children ...
Belsky Daniel W DW Duke University Medical Center, Center for the Study of Aging and Human Development , 2020 W Main St. , Suite 201 , Durham, North Carolina, United States, 27708 , 919-613-4534 ; - - 2014
Background. Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multi-system phenotype of accelerated aging. Objective. To test whether chronic asthma is associated with a proposed biomarker of accelerated aging, leukocyte telomere length. Method. Asthma was ascertained prospectively in ...
Griffin Justin W JW Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA, - - 2014
Elderly and young patients alike are undergoing shoulder replacement at increased rates. In an era of outcomes reporting, risk adjustment, and cost containment, identifying patients likely to have adverse events is increasingly important. Our objective was to determine whether patient age is independently associated with postoperative in-hospital complications or increased ...
Nakano Makiko - - 2014
Background:Dose-dependent adverse lung effects due to indium exposure have been reported in a cross-sectional study. This is a 5-year longitudinal cohort study of indium-exposed and unexposed workers, assessing indium exposure levels and its clinical lung effects. Methods:From 2008 to 2011, a 5-year follow-up study was conducted on 40 unexposed and ...
Cheng Daomei - - 2014
Objective An intervention study was performed to determine if supplement containing folic acid, vitamin B6, and vitamin B12 could improve cognitive function and lower homocysteine in middle-aged and elderly patients with hyperhomocysteinemia. Methods One hundred and four participants with hyperhomocysteinemia were recruited in Tianjin, China, aged 55-94 years old. Fifty-seven ...
Itty Sujit S *Department of Ophthalmology, Duke University Medical Center; †Department of Ophthalmology, Stanford Medical Center; ‡Department of Medicine, Duke University Medical Center; §Geriatric Research Education and Clinical Centers, Veterans Affairs Medical Center, Durham, North Carolina; ¶The Carolinas Center for Medical Excellence, Cary, North Carolina; and **Division of Biostatistics, Duke University Medical - - 2014
To compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients. Medical records of all patients diagnosed with age-related macular degeneration and tested for serum 25OHD level at a single medical center were reviewed. Control patients were ...
WysokiƄski A A Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, - - 2014
Introduction: The present study was undertaken to determine if patients with schizophrenia on clozapine monotherapy have lower serum levels of peptide YY [PYY(1-36)], which is an endogenous inhibitor of food intake, comparing to healthy controls. Methods: Data for 24 patients (mean age 38.8 years) with paranoid schizophrenia on clozapine monotherapy ...
Klingberg Eva E From the Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden. Supported by grants from The Health and Medical Care Executive Board of the Västra Götaland, Rune and Ulla Amlövs foundation for Rheumatology Research, Göteborg's Association Against Rheumatism, The Medical Society of Göteborg, the Medical Society of Göteborg and the Region Västra Götaland (agreement concerning research and education of doctors), COMBINE, the Margareta Rheuma research foundation, and the Inger Bendix foundation. E. Klingberg, MD, PhD; M. Nurkkala, PhD; H. Carlsten, MD, PhD, Professor; H. Forsblad-d'Elia, MD, PhD, Associate professor, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg. Address correspondence to Dr. E. Klingberg, Department of Rheumatology at Sahlgrenska/SU, Gröna stråket 14; S-413 45 Gothenburg, Sweden. E-mail: Eva.Klingberg@vgregion.se. Accepted for publication March 7, - - 2014
To identify biomarkers for bone metabolism in patients with ankylosing spondylitis (AS) and to determine the relationship between these biomarkers and disease activity, back mobility, osteoproliferation, and bone mineral density (BMD). Serum levels of Wingless protein (Wnt-3a), Dickkopf-1 (DKK-1), sclerostin, soluble receptor activator of nuclear factor-κΒ ligand (sRANKL), and osteoprotegerin ...
Rossi-Izquierdo Marcos M Department of Otolaryngology, University Hospital Lucus Augusti, Calle Dr. Ulises Romero, 1, 27003, Lugo, Spain, - - 2014
To assess whether a subjective questionnaire that measures the disability caused by balance disorders in daily life activities is correlated to objective assessment of balance in elderly patients with age-related instability. We included 37 subjects aged 65 years or more who presented balance disorders induced solely by age. Balance assessment was ...
Bakolis I I Small Area Health Statistics Unit, MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, - - 2014
Exposure to house dust has been associated with asthma in adults, and this is commonly interpreted as a direct immunological response to dust mite allergens in those who are IgE sensitised to house dust mite. Mattress house dust mite concentrations were measured in a population based sample of 2890 adults ...
Güngör Sirel Gür SG Department of Ophthalmology, Faculty of Medicine - - 2014
Abstract Purpose: To evaluate the choroidal thickness in patients with ocular sarcoidosis during quiescent phase using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing it with normal subjects. Method: Eighteen eyes of 9 patients with ocular sarcoidosis (8 women, 1 man, mean age: 59.12 ± 18.49 years) were enrolled in this ...
Sjodin Andreas - - 2014
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) have been measured in serum collected in 2009 from a convenience sample of surplus serum from 300 Texas children (boys and girls) in the zero to 13 years of age range. Serum concentrations of traditional persistent organic pollutants such as ...
Wang Su-Fang SF Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University , Hefei, Anhui , - - 2014
In this study, we report the relationship between hyperuricemia and hypertension in a middle-aged Chinese population, emphasizing the difference of gender. The cross-sectional study was conducted among 1776 adults aged 45-60 years, who participated in the Hefei Nutrition and Health Study (2012). Hyperuricemia was defined as serum uric acid (SUA)> ...
Kerola Anne M AM Medical School, University of Helsinki, Helsinki, Finland. - - 2014
To evaluate the prevalence of levothyroxine-treated hypothyroidism in rheumatoid arthritis (RA) patients at the time of RA diagnosis in comparison to age- and sex-specific general population. Other objectives were to determine whether the risk of hypothyroidism varies by age at the onset of RA, or by sex or rheumatoid factor ...
Milian Monika M Department of Neurosurgery, University Hospital Tuebingen, - - 2014
Background: Female Cushing's disease (CD) patients with active disease present more frequently with depression compared to their male co-sufferers. This study investigated whether the gender difference prevails after remission and whether gender-specific factors contributing to mental health exist. Methods: Seventy-two biochemically cured CD patients (11 male, mean age 45.9 ± ...
Wilhelmsson Mari - - 2014
Testicular dysfunction and infertility are of major concern in long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). This study assesses predictive factors for very long-term testicular recovery after allogeneic HSCT in childhood and adolescence. Testicular volume, sperm production and long-term need of testosterone substitution were evaluated among 106 male ...
Katsuura-Kamano Sakurako S Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima, Japan, - - 2014
Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels ...
Cerman Eren E Department of Ophthalmology, Marmara University School of Medicine, Istanbul, Turkey. Electronic address: - - 2014
To determine the oldest age beyond which the chance of developing stereopsis is not possible even with excellent motor alignment in patients with infantile esotropia. The medical records of children with infantile esotropia who underwent a single operation and had alignment within 10(Δ) of orthotropia at all follow-up examinations were ...
Yi Shuhua S State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, - - 2014
Waldenström macroglobulinemia (WM) is an uncommon lymphoid malignancy. The characteristics and prognosis of WM have never been systematically studied in the East. We analyzed the clinical characteristics and the prognostic factors of 90 Chinese WM patients, and compared them with the Western reports. The median age was 62 years old ...
Shi Dongmin D Department of Laboratory Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, P.R. - - 2014
Cerebral infarction is usually associated with arteriosclerosis, vascular endothelial cell injury and blood flow through the vascular system. The diagnostic value of markers, including von Willebrand factor antigen (vWF:Ag), D-dimer (D-D) and fibrinogen/fibrin degradation product (FDP), have not been studied in patients with acute cerebral infarction. Thus, the aim of ...
Rosario Pedro Weslley PW Santa Casa de Belo Horizonte, Belo Horizonte, MG, - - 2014
Objective: To establish serum TSH reference values for a population of Brazilian elderly, and to compare them to those found in the adult population. Subjects and methods: Healthy volunteers aged 70 to 85 years, without known thyroid disease or risk factors for thyroid dysfunction, who did not use any medication ...
Bener Abdulbari A Department of Medical Statistics and Epidemiology, Hamad Medical Corporation and Department of Public Health, Weill Cornell Medical College, Doha, Qatar. ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, - - 2014
Cross-sectional. The purpose of the study was to determine the prevalence of low back pain (LBP) in the primary care setting with emphasis on the socio-demographic contributing factors and impact of LBP on lifestyle habits. LBP is one of the most common medical conditions seen in the Primary Health Care ...
Adriani A A Department of Gastroenterology and Hepatology San Giovanni Battista (Molinette) Hospital, Turin, Italy - - - 2014
The decrease in bone density may occur as a result of inflammatory bowel disease (IBD). Studies conducted on this issue generally focused on treated IBD patients. It is thus difficult to discriminate the role of disease from the effect of therapy on bone density reduction. We evaluated the prevalence of ...
Rej Soham S Resident, Department of Psychiatry, McGill University, Montreal, - - 2014
Despite being a common and potentially serious condition, nephrogenic diabetes insipidus (NDI) remains poorly understood in older lithium users. Our main objective was to compare the prevalence of NDI symptoms and decreased urine osmolality ([UOsm] < 300 milli-Osmoles [mOsm/kg]) among geriatric and adult lithium users. We also assessed NDI symptoms, ...
Chong Elaine W EW *MBBS, PhD †MD, MPH ‡PhD §MD, PhD Centre for Eye Research Australia, the University of Melbourne, Victoria, Australia (EWC, RHG, JJW, TYW); Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin (RK, BEK); Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland (MFC); Centre for Vision Research, University of Sydney, Sydney, Queensland, Australia (JJW); Departments of Medicine, Epidemiology and Biostatistics, San Francisco VA Medical Center, University of California, San Francisco, California (MGS); and Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore - - 2014
Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD. A population-based, cross-sectional analysis of persons aged 45 ...
Stahl Christopher C CC Cincinnati Research in Outcomes and Safety in Surgery, Department of Surgery, University of Cincinnati, 234 Goodman St, ML 0772, Cincinnati, OH, 45219, - - 2014
Esophagectomy is a high-risk surgical procedure. As the population ages, more elderly candidates are being evaluated for esophagectomy. The effects of patient age on outcomes after esophagectomy need to be evaluated. We identified all nonemergent esophagectomies in patients at least 18 years of age within the University HealthSystems Consortium Clinical Database/Resource ...
Chen Aimin A Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, - - 2014
Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that were widely used as flame retardants in furniture, carpet padding, car seats and other consumer products over the past three decades. To examine whether in utero exposure to PBDEs is associated with child cognitive function and behavior in a U.S. study sample. ...
Bo T T Jiangsu University, Zhenjiang, Jiangsu Province, - - 2014
The aim of the study was to investigate the influence of serum testosterone concentrations on bone mineral densities (BMDs) in healthy aged men in Shanghai area. Eighty-four participants, registered in the physical examination center of our hospital were included. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to measure concentrations ...
Matell Henrik H Karolinska University Hospital, Sweden - - 2014
Natalizumab is approved for treatment of active forms of relapsing-remitting multiple sclerosis (MS) based on a pivotal phase III study comprising patients aged 18-50 years. The effect of natalizumab has not been specifically studied in older patients. We analyzed age-dependent effects on treatment-related outcome measures in 1872 patients, 189 of ...
Behrens Janina - - 2014
We investigated the applicability and feasibility of perceptive computing assisted gait analysis in multiple sclerosis (MS) patients using Microsoft KinectTM. To detect the maximum walking speed and the degree of spatial sway, we established a computerized and observer-independent measure, which we named Short Maximum Speed Walk (SMSW), and compared it ...
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