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Russell J R W JR Department of Plant Sciences, University of Oxford, Oxford, - - 2014
Separate sexes have evolved on numerous independent occasions from hermaphroditic ancestors in flowering plants. The mechanisms of sex determination is known for only a handful of such species, but, in those that have been investigated, it usually involves alleles segregating at a single locus, sometimes on heteromorphic sex chromosomes. In ...
Hassen Anwar Seid AS Dubti Pastoral and Agro-Pastoral Research Center, Afar Pastoral and Agro-Pastoral Research Institute, P.O. Box 16, Samara, Ethiopia, - - 2014
The study was conducted in Chifra district in Awsi-Resu zone of Afar Regional State to explore production objectives and strategies of sheep and goats in pastoral and agro-pastoral production systems. Cross-sectional survey with systematic random selection of 180 households (90 households from each production system was conducted. Descriptive statistics, t ...
Bouchard Jill J Department of Anatomy, University of California San Francisco, San Francisco, California, 94143, USA; The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, 94143, - - 2014
The effects of aging were traditionally thought to be immutable, particularly evident in the loss of plasticity and cognitive abilities occurring in the aged central nervous system (CNS). However, it is becoming increasingly apparent that extrinsic systemic manipulations such as exercise, caloric restriction, and changing blood composition by heterochronic parabiosis ...
Rose Michael R MR Department of Ecology and Evolutionary Biology, University of California, Irvine, Calif., - - 2015
There is not one systems biology of aging, but two. Though aging can evolve in either sexual or asexual species when there is asymmetric reproduction, the evolutionary genetics of aging in species with frequent sexual recombination are quite different from those arising when sex is rare or absent. When recombination ...
Hardeland Rüdiger R Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Göttingen, Göttingen, - - 2015
From the perspective of systems biology, melatonin is relevant to aging in multiple ways. As a highly pleiotropic agent, it acts as a modulator and protectant of mitochondrial electron flux, a potent antioxidant that supports the redox balance and prevents excessive free radical formation, a coregulator of metabolic sensing and ...
Abrams Alan P AP Geriatric Medical Fellowship Program, Division of Gerontology, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: - - 2014
This article reviews the concepts of physiologic reserve, the principles of the normative aging process as exemplified by the cardiovascular, neurologic, and musculoskeletal systems. How these principles apply to oral health, and age-related changes in the oral cavity itself, is reviewed and suggests how they may affect disease management by ...
Bgatova Natalia N Research Institute of Clinical and Experimental Lymphology Siberian Branch of RAMS, Novosibirsk, - - 2014
The neurodegeneration is one of the features of aging and age-related disorders. Yet, only several antiaging interventions are known to affect the processes of neurodegeneration. Here we show that overexpression of the pro-longevity gene D-GADD45 in Drosophila neurons leads to a postponed manifestation of histological and ultrastructural features of age-dependent ...
Vellé Alba A Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC , 50009 Zaragoza, - - 2014
A cationic [Ag2(bis-NHC)2](2+) system behaves as an excellent host for Ag(+). In the solid-state variation, Ag···Ag are the only bonding interactions between host and guest, overcoming their inherent electrostatic repulsion. It represents a clear example of ligand-unsupported ("pure") argentophilicity. In solution, we also found evidence for this kind of Ag···Ag ...
Tang Bor Luen BL Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Medical Drive, Singapore - - 2014
We hypothesize herein that synthetic mitochondria, engineered or reprogrammed to be more energetically efficient and to have mildly elevated levels of reactive oxygen species (ROS) production, would be an effective form of therapeutics against systemic aging. The free radical and mitochondria theories of aging hold that mitochondria-generated ROS underlies chronic ...
Arismendi Ebymar E Servei de Pneumologia (Institut Clínic del Tòrax), Hospital Clínic, Barcelona, Spain; Fundació Clínic per la Recerca Biomèdica, Hospital Clínic, Barcelona, Spain; CIBER Enfermedades Respiratorias (CIBERES), Barcelona and Palma de Mallorca, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, - - 2014
Obesity is associated with low-grade systemic inflammation. The "inflammome" is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery ...
Nasto Luigi A - - 2012
NF-κB activity was pharmacologically and genetically blocked in an accelerated aging mouse model to mitigate age-related disc degenerative changes. To study the mediatory role of NF-κB-signaling pathway in age-dependent intervertebral disc degeneration. Aging is a major contributor to intervertebral disc degeneration (IDD), but the molecular mechanism behind this process is ...
Mantagou Lito - - 2012
OBJECTIVES:To provide data on the natural course of transcutaneous bilirubin (TcB) levels in neonates before the development of significant hyperbilirubinemia, and to assess the effect of different demographic and perinatal factors on the rate of TcB increase.METHODS:We analyzed 2454 TcB measurements from 419 neonates before the development of significant hyperbilirubinemia. ...
Kwok Anthony Wl - - 2012
ABSTRACT: Study Design. Cross-sectional study.Objective: To investigate changes in the morphology of the lumbar vertebrae and intervertebral discs associated with osteoporosis of the spine in elderly subjects.Summary of Background Data: Osteoporosis is a common condition that primarily affects the elderly with significant impact on quality of life. How exactly osteopenia ...
Cheng Xiaofei X Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Rd, Huangpu District, Shanghai 200003, People's Republic of - - 2013
The goal of this study was to determine which paraspinal approach provided a better transverse screw angle (TSA) for each vertebral level in lower lumbar surgery. Axial computed tomography (CT) images of 100 patients, from L3 to S1, were used to measure the angulation parameters, including transverse pedicle angle (TPA) ...
Lee Michael J - - 2012
ABSTRACT: Study Design. Systematic ReviewObjective. To determine the population risk of radiographic degeneration in the lumbar and cervical spine as well as the risk of adjacent segment pathology (ASP) among patients who receive and do not receive (but were eligible for) fusion for lumbar or cervical degeneration.Summary of Background Data. ...
Shaikh Kashif Ajaz - - 2012
: Pedicle screw fixation has a number of advantages over other methods of spine instrumentation. The anatomy of the pedicle is complex, however there are basic dimensions important for planning screw placement. Pedicle anatomy has been studied extensively in adults; however, there are only a few small studies examining the ...
Perdigão J - - 2012
SUMMARY The objective of this project was to study the influence of artificial aging and surface treatment on the microtensile bond strengths (μTBS) between zirconia and a phosphate monomer-based self-adhesive cement. Thirty zirconia disks (IPS e.max ZirCAD, Ivoclar Vivadent) were randomly assigned to two aging regimens: AR, used as received, ...
Watanuki Atsunori - - 2012
BACKGROUND: Little information is available on the prevalence, incidence, and risk factors associated with curve progression in de-novo degenerative lumbar scoliosis (DNDLS) in the general population. Development of treatment guidelines requires further knowledge about the etiology and natural history of DNDLS in the elderly. METHODS: To identify the cumulative incidence ...
Hsu Sheng-Yao - - 2012
The aim here was to investigate whether optic nerve head (ONH) parameters or retinal nerve fibre layer (RNFL) thickness correlate with age or disc area and whether the neuroretinal rim correlates with RNFL thickness. This cross-sectional study enrolled 133 healthy subjects and analysed one randomly selected eye of each subject. ...
Wang Yue - - 2012
Clinical observations suggest that endplate shape and size are related to complications of disc arthroplasty surgery. Yet, the morphology of the vertebral endplate has not been well defined. This study was conducted to characterize the morphology of lumbar vertebral endplates and to quantify their morphometrics using radiographic, visual and digital ...
Sivan Sarit-Sara - - 2012
BACKGROUND: Ageing and degeneration of human intervertebral disc (IVD) are associated with biochemical changes, including racemization and glycation. These changes can only be counteracted by protein turnover. Little is known about the longevity of IVD elastin in health or disease. Yet, such knowledge is important for a quantitative understanding of ...
Blake Glen M - - 2012
The T-score discordance among skeletal sites is an important aspect of dual-energy X-ray absorptiometry (DXA) measurements. In the spine, large T-score differences between vertebrae are frequently seen in elderly patients owing to degenerative disease. However, it is unclear how often such differences occur in younger adults with healthy spines. The ...
Ergun Tarkan - - 2012
OBJECTIVES: To investigate whether there is any relationship between the prevalence and the dimension of OLF and the presence and degree of facet joint degeneration. In addition, it revealed the prevalence and distribution of lumbar OLF with regard to age and spinal levels. METHODS: The stone protocol abdominal CT images ...
Darelid Anna - - 2012
The aim of this study was to investigate the development of bone mineral density (BMD) and content (BMC) in relation to peak height velocity (PHV), and to investigate whether late normal puberty was associated with remaining low BMD and BMC in early adulthood in men. In total, 501 men (18.9 ± 0.5 ...
Cho Nam H - - 2012
Study Design. A community-based, cross-sectional study that is part of the prospective Korean Health and Genome Study.Objective. To determine the prevalence of low back pain (LBP) among middle-aged and elderly rural community residents in Korea and to examine the relevant risk factors, including activities reflecting the Asian lifestyle, and the ...
Shaikh Kashif A - - 2012
PURPOSE: The anatomy of the pedicle is complex and three-dimensional; however, there are basic dimensions important for possible screw placement. There are relatively few studies examining the pedicle anatomy in children. This study was performed to evaluate the feasibility of pedicle screw placement in children aged 5-16, based on key ...
Gonnelli Stefano - - 2012
This study aimed to investigate the associations of body composition and fat distribution with bone mineral density (BMD) in elderly Italian subjects. In 866 women (age 64.2±6.5yr) and 168 men (age 65.1±6.1yr), we measured BMD at lumbar spine, at femur, at the total body, and at the right hand. In ...
Grieshop Karl - - 2012
That male genital morphology evolves via postcopulatory sexual selection is a widely held view. In contrast, the precopulatory sexual selection hypothesis for genital evolution has received less attention. Here, we test the hypothesis that male genital spines of Drosophila ananassae promote competitive male copulation success. Using laser surgery to manipulate ...
Samartzis Dino - - 2012
To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. A population-based cross-sectional study of 2,599 southern Chinese volunteers was conducted. Subjects underwent radiographic and clinical assessment, and weight and height were measured. Sagittal ...
Crandall Carolyn J - - 2012
Adult bone mass depends on acquisition in childhood and decline in adulthood, and may be influenced by socioeconomic conditions over the entire life course. We examined associations of bone mineral density (BMD) in adulthood with life course socioeconomic status in 729 participants in the Midlife in the United States Biomarker ...
Schober H C - - 2012
This study reports gender-specific vertebral area gain data from children and adolescents. Vertebral area was measured on lateral and anteroposterior thoracic and lumbar spine radiographs from 100 female and 100male subjects aged 7-28yr. T9, T11, T12, L1, and L2 X-ray area calculation was based on calculation of the area of ...
Wang Yue - - 2012
BACKGROUND CONTEXT: Suspected as a cause of back pain, Modic changes (MCs) have received increasing attention in spine research and care. Yet, epidemiologic knowledge of MCs based on the general population, which may provide an important clinical reference, is limited. PURPOSE: To investigate the prevalence and distribution patterns of MCs ...
Kovacs F M - - 2012
Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects. Patients in this study serving as cases were 35-50 years of age with low back pain lasting >90 days, for whom a ...
Jimbo Shizuo - - 2012
STRUCTURED ABSTRACT: Study Design. A 12-year prospective study of pre-existing and de novo degenerative lumbar scoliosis (DLS) among community-based female volunteers.Objective. To investigate serial entire spine radiograph of healthy female volunteers and to clarify radiographic characteristics and predictors of pre-existing and de novo DLS.Summary of Background Data. DLS is among ...
Suri Pradeep - - 2012
Vascular disease has been proposed as a risk factor for disc height loss (DHL). To examine the relationship between quantitative measures of abdominal aortic calcifications (AACs) as a marker of vascular disease, and DHL, on computed tomography (CT). Cross-sectional study in a community-based population. Four hundred thirty-five participants from the ...
Aversa Antonio - - 2012
We evaluated the effects of long-term testosterone replacement therapy (TRT) on the bone mineral density (BMD) in obese patients with metabolic syndrome (MS) and late-onset hypogonadism (LOH). Sixty men (mean age 57 ± 10) with low serum testosterone (T < 320 ng/dL) and MS regardless the presence of osteoporosis were enrolled. Forty men ...
Knapp Karen M - - 2012
The precision errors of dual-energy X-ray absorptiometry (DXA) measurements are important for monitoring osteoporosis. This study investigated the effect of body mass index (BMI) on precision errors for lumbar spine (LS), femoral neck (NOF), total hip (TH), and total body (TB) bone mineral density using the GE Lunar Prodigy. One ...
Zárate-Kalfópulos Barón - - 2012
Object The aim of this study was to describe the pelvic parameters in a sample of healthy Mexican volunteers and to compare them with previously reported data for Caucasian and Asian populations. Methods This was a transversal study that included a sample population of healthy Mexican volunteers. Age, sex, and ...
Knight O'Rese J - - 2012
OBJECTIVE: To determine the effect of race, demographic, and ocular variables on optic nerve head and retinal nerve fiber layer (RNFL) thickness measurements using spectral-domain optical coherence tomography. METHODS: In a cross-sectional observational study, 284 normal subjects aged 18 to 84 years were evaluated at 7 sites using Cirrus HD-OCT. ...
Celan Dusan - - 2012
The purpose of the first part of the study was to establish the variability of repeated measurements in different measuring conditions. In the second part, we performed in a large number of patients, a measurement of thoracic kyphosis and lumbar lordosis and compared them to age, gender, and level of ...
Sousa Vicelina B - - 2012
Teak (Tectona grandis) is one of the most valuable timbers in international trade and an important species for tropical forestry. Teak is found on the island of East Timor but no information is available on teak growth from this region. A pure stand planted in 1940-50 in the North of ...
Toy Jason O - - 2012
SUMMARY OF BACKGROUND DATA:: Spinal osteoarthritis is greater in patients with known hip pathology secondary to alterations in spinopelvic geometry. To our knowledge, no study has investigated the long-term impact of slipped capital femoral epiphysis (SCFE) on the spine. OBJECTIVE:: To evaluate the relationship between SCFE and the presence of ...
Hernández-Orts Jesús S - - 2012
SUMMARYAcanthocephalans have evolved a hooked proboscis and some taxa have trunk spines to attach to their definitive hosts. These structures are generated before being used, thus a key question is how investment in attachment could optimally be allocated through the ontogeny. The number and arrangement of hooks and spines are ...
Weiss Hans-Rudolf - - 2012
A physiologic sagittal alignement of the spine with lumbar lordosis and thoracic kyphosis is the most stable position of the spine, while in patients with Idiopathic Scoliosis (IS) the sagittal profile of the spine is flattened or inversed. It has been shown that a correction of the sagittal profile also ...
Schlösser T - - 2012
Aim: To evaluate the closure pattern and symmetry of the left and right neurocentral junctions (NCJs) in the normal growing spine, in relation to preexistent spinal rotation and to the convexity of the curve in idiopathic scoliosis. Methods: CT scans of the thorax and abdomen of 199 non-scoliotic children (0-16 ...
Pezowicz Celina - - 2012
A good understanding of thoracic biomechanics is important for complete examination and control of chest behaviour under conditions of physiological and pathological work, and under the impact of external forces leading to traumatic loading of the chest. The purpose of the study was to analyse the mechanical properties of human ...
Liu Zhen - - 2012
Abnormal pattern of growth has been reported in adolescent idiopathic scoliosis (AIS) patients. However, the sequential changes of growth in different curve types of AIS have not been properly studied. The present study aimed to investigate the body growth characteristics of girls with single thoracic idiopathic scoliosis and lumbar idiopathic ...
Castelein René M - - 2012
The normal spine is not a symmetrical structure, as has been appreciated for a long time. The reason why the main thoracic vertebrae in idiopathic scoliosis predominantly rotate to the left at the infantile age and to the right at the adolescent age is unclear. We provided an in-depth analysis ...
Bae Jun Seok - - 2012
To compare radiographic analysis on the sagittal lumbar curve when standing, sitting on a chair, and sitting on the floor. Thirty asymptomatic volunteers without a history of spinal pathology were recruited. The study population comprised 11 women and 19 men with a mean age of 29.8 years. An independent observer ...
Klingberg Eva - - 2012
Osteoporosis can be a complication of ankylosing spondylitis (AS), but diagnosing spinal osteoporosis can be difficult since pathologic new bone formation interferes with the assessment of the bone mineral density (BMD). The aims of the current study were to investigate prevalence and risk factors for reduced BMD in a Swedish ...
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