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Koyama E E Division of Orthopaedic Surgery - - 2014
The Proteoglycan 4 (Prg4) product lubricin plays essential roles in boundary lubrication and movement in limb synovial joints, but its roles in temporomandibular joint (TMJ) are unclear. Thus, we characterized the TMJ phenotype in wild-type and Prg4(-/-) mouse littermates over age. As early as 2 weeks of age, mutant mice ...
Fu Yuhong Y Neuroscience Research Australia, Sydney, NSW, Australia School of Medical Science, The University of New South Wales, Sydney, NSW, - - 2014
The J20 mouse expresses human mutant amyloid-β protein precursor (hAβPPSwInd) and is an established transgenic model of Alzheimer's disease (AD). From the age of 5 months, amyloid-β (Aβ) deposits appear in the hippocampus with concomitant increase of AD-associated features. Although changes occurring after the appearance of Aβ deposits have been ...
Raj Divya D A DD Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, the - - 2014
Aging is associated with reduced function, degenerative changes, and increased neuroinflammation of the central nervous system (CNS). Increasing evidence suggests that changes in microglia cells contribute to the age-related deterioration of the CNS. The most prominent age-related change of microglia is enhanced sensitivity to inflammatory stimuli, referred to as priming. ...
Pérez-Jiménez Mercedes M MM Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas - Universidad Pablo de Olavide - Junta de Andalucía, Carretera de Utrera, km1, Seville, 41013, - - 2014
Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the NE are a causal effect of normal and premature aging is still controversial. ...
Riesen Michèle M Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United - - 2014
In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor. Here we describe the role of mdl-1 in C. elegans germline proliferation and aging. The deletion allele mdl-1(tm311) shortened lifespan, and did so significantly more so ...
Yang Su S Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Room 355, Atlanta, GA 30322, - - 2014
Although protein-misfolding-mediated neurodegenerative diseases have been linked to aging, how aging contributes to selective neurodegeneration remains unclear. We established spinocerebellar ataxia 17 (SCA17) knockin mice that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamoxifen-mediated Cre recombination. We find that more mutant TBP ...
Yamamoto T T Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, - - 2014
This study compared the growth rates of female masu salmon Oncorhynchus masou, who possessed a male-specific gene marker, the growth hormone pseudogene (GHp), and normal females, as estimated from their scale growth. There was a difference between the growth rates of GHp-positive females and those of normal females of the ...
Fraser Eleanor J EJ Program in Genetics, Department of Anatomy, University of California San Francisco, San Francisco, California, United States of - - 2014
Olfaction exerts a profound influence on reproductive physiology and behavior in many animals, including rodents. Odors are recognized by sensory neurons residing in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) in mice and many other vertebrates. The relative contributions of the MOE and VNO in the display ...
Bilen Julide J Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA - - 2013
Juvenile hormone (JH) coordinates timing of female reproductive maturation in most insects. In Drosophila melanogaster, JH plays roles in both mating and egg maturation. However, very little is known about the molecular pathways associated with mating. Our behavioral analysis of females genetically lacking the corpora allata, the glands that produce ...
Marcil-Ferland Dominique - - 2013
Abstract Individuals experiencing poor growth early in life may later make up their size deficit. Compensatory growth or growth prolongation may lead to such catch-up, involving different life-history trade-offs under natural conditions. Frequent recaptures and detailed monitoring of animals surviving to asymptotic size are required to compare growth tactics and ...
English Sinead S Large Animal Research Group, Department of Zoology, University of Cambridge Cambridge, CB2 3EJ, - - 2013
In polygynous species, variance in reproductive success is higher in males than females. There is consequently stronger selection for competitive traits in males and early growth can have a greater influence on later fitness in males than in females. As yet, little is known about sex differences in the effect ...
Kowald Axel - - 2013
The mitochondrial theory of ageing is one of the main contenders to explain the biochemical basis of the ageing process. An important line of support comes from the observation that mtDNA deletions accumulate over the life course in post-mitotic cells of many species. A single mutant expands clonally and finally ...
Petrosyan Agavni - - 2013
Methuselah (mth) is a chromosome 3 Drosophila mutant with an increased lifespan. A large number of studies have investigated the genetic, molecular, and biochemical mechanisms of the mth gene. Much less is known about the effects of mth on preservation of sensorimotor abilities throughout Drosophila's lifespan, particularly in late life. ...
Avchalumov Yosef - - 2013
Abnormal plasticity in the cortico-basal ganglia-thalamocortical loop has been suggested to represent a key factor in the pathophysiology of dystonia. In a model of primary paroxysmal dystonia, the dt(sz) mutant hamster, previous experiments have shown a strongly increased long-term-potentiation (LTP) in comparison to non-dystonic control hamsters. These basal changes, i.e. ...
Lucanic Mark M Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. - - 2013
Non-coding small RNAs of the micro-RNA class (miRNA) are conserved regulators of gene function with a broad impact on biological processes. We screened miRNA levels for age-related changes in individual worms and investigated their influence on the lifespan of the nematode C. elegans. We measured the abundance of 69 miRNAs ...
Behrendt Rayk - - 2013
Aicardi-Goutières syndrome (AGS) is a hereditary autoimmune disease, which clinically and pathogenetically overlaps with SLE and therefore can be regarded as a monogenic variant of SLE. Both conditions are characterized by chronic activation of antiviral type I IFN responses. AGS can be caused by mutations in one of several genes ...
Zhang Shasha S State Key Laboratory of Biomembrane and Membrane Biotechnology and Peking-Tsinghua Center for Life Sciences, School of Life Sciences, and Peking University-International Data Group-McGovern Institute for Brain Research, Peking University, Beijing 100871, - - 2013
A role for serotonin in male sexual preference was recently uncovered by our finding that male mutant mice lacking serotonin have lost sexual preference. Here we show that female mouse mutants lacking either central serotonergic neurons or serotonin prefer female over male genital odors when given a choice, and displayed ...
Rakshit Kuntol - - 2013
Circadian clocks generate daily rhythms in molecular, cellular, and physiological functions providing temporal dimension to organismal homeostasis. Recent evidence suggests two-way relationship between circadian clocks and aging. While disruption of the circadian clock leads to premature aging in animals, there is also age-related dampening of output rhythms such as sleep/wake ...
Godfrey Anna L AL Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Cambridge, - - 2013
Subclones homozygous for JAK2V617F are more common and larger in patients with polycythemia vera compared to essential thrombocythemia, but their role in determining phenotype remains unclear. We genotyped 4564 erythroid colonies from 59 patients with polycythemia vera or essential thrombocythemia to investigate whether the proportion of JAK2V617F -homozygous precursors, compared ...
Bartke Andrzej A Southern Illinois University School of Medicine, Department of Internal Medicine, Geriatric Research, Springfield, Illinois 62703, USA. - - 2013
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the "healthspan" is also extended with delays in ...
Scherfer Christoph C Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Unit 1000, Houston, TX 77030, - - 2013
Organismal lifespan has been the primary readout in aging research. However, how longevity genes control tissue-specific aging remains an open question. To examine the crosstalk between longevity programs and specific tissues during aging, biomarkers of organ-specific aging are urgently needed. Since the earliest signs of aging occur in the skin, ...
Singh Lakshman L Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2013
Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important cellular mechanism that may in part explain osteoblast dysfunction that occurs with aging is senescence of mesenchymal progenitor cells (MPCs). In the telomere-based Wrn(-/-) Terc(-/-) model of accelerated ...
Berry Miriam R MR Division of Renal Medicine, University of Cambridge, Cambridge, - - 2013
Gitelman syndrome (GS) is a rare inherited disorder caused by mutations in SLC12A3, encoding the thiazide-sensitive transporter NCCT (sodium chloride co-transporter) in the distal tubule. It is characterized by renal potassium (K) and magnesium (Mg) wasting, relative hypotension and hypocalciuria. However, there is phenotypic variability and long-term studies are scarce. ...
Büchter Christian - - 2013
Myricetin is a naturally occurring flavonol found in many plant based food sources. It increases the lifespan of Caenorhabditis elegans, but the molecular mechanisms are not yet fully understood. We have investigated the impact of this flavonoid on the transcription factors DAF-16 (C. elegans FoxO homologue) and SKN-1 (Nrf2 homologue), ...
Sputova Klara K Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. - - 2013
Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomerase activity correlated with age in normal human mammary epithelial cells (HMEC), or with phenotypes of aging in breast. Accordingly, flow ...
Fenton Richard A - - 2012
Adenosine (ADO) released in the heart results in enhanced coronary blood flow and reduced catecholamine release and myocardial responsiveness to adrenergic stimulation (anti-adrenergic action). ADO release from the adrenergic-stimulated aged heart is less than that from the young adult heart. Because adrenergic signaling in the aged heart is impaired, this ...
Dallaire Alexandra - - 2012
Small non-coding microRNAs are believed to be involved in the mechanism of aging but nothing is known on the impact of microRNAs in the progeroid disorder Werner syndrome (WS). WS is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the ...
Meyer Lauren L University of Washington School of Medicine, Seattle, WA 98195, - - 2012
Sudden cardiac arrest is a leading cause of death in children and young adults. This study determined the incidence, cause, and outcomes of cardiovascular-related out-of-hospital cardiac arrest (OHCA) in individuals <35 years of age. A retrospective cohort of OHCA in children and young adults from 1980 through 2009 was identified ...
Babušíková E - - 2012
Altered Ca(2+) handling may be responsible for the development of cardiac contractile dysfunctions with advanced age. In the present study, we investigated the roles of oxidative damage to sarcoplasmic reticulum (SR) and expression of Ca(2+)-ATPase (SERCA 2a) and phospholamban in age-associated dysfunction of cardiac SR. SR vesicles were prepared from ...
Taylor Anne L - - 2012
Fixed-dose combined isosorbide dinitrate/hydralazine (FDC I/H) significantly improved outcomes in patients with advanced heart failure (HF) receiving background neurohormonal therapy in the African-American Heart Failure Trial (A-HeFT). In this analysis, we investigated treatment effects by age <65 or ≥65 years. Time-to-event curves were produced by the Kaplan-Meier method. Hazard ratios ...
Navarro-Otano Judith - - 2012
BACKGROUND: In Parkinson's disease (PD), alpha-synuclein (AS) aggregates occur frequently in peripheral autonomic nervous system (pANS). Their presence in asymptomatic subjects suggests incidental Lewy-body disease (iLBD) that is thought to reflect pre-clinical PD. Cardiac involvement has been detected in post-mortem studies in both, PD and also in iLBD. In vivo documentation ...
Smith D - - 2012
Previous reports indicate that the "athlete's heart" is more prominent in males than females, but the mechanisms responsible for this sex difference have not been elucidated. This study examined male-female differences in cardiac mass and volume in highly trained athletes and normally active individuals to assess the relative contributions of ...
Sliwa Karen - - 2012
Historically, sub-Saharan Africa has reported low levels of atherosclerotic cardiovascular disease (CVD). However as these populations undergo epidemiological transition, this may change. This was an observational cohort study performed at Chris Hani Baragwanath Hospital in Soweto, South Africa. As part of the Heart of Soweto study, a clinical registry captured ...
Havmoeller Rasmus R Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, - - 2013
Sudden cardiac death (SCD) is a large public health problem that warrants on-going evaluation in the general population. While single-year community-based studies have been performed there is a lack of studies that have extended evaluation to multiple years in the same community. From the on-going Oregon Sudden Unexpected Death Study, ...
Adam Martin - - 2012
BACKGROUND: Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES: We investigated whether long-term exposure to traffic-related PM(10) (TPM(10)) is associated with HRV in older subjects and/or in participants taking specific cardiovascular treatment or with self-reported heart disease. METHODS: ...
Phillips Anna C AC School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United - - 2012
In recent analyses of data from a large community sample, negative cross-sectional and prospective associations between cardiac stress reactivity and obesity were observed. The present study reexamined the association between cardiovascular reactivity and adiposity in the Dutch Famine Birth Cohort, with the additional aim of examining the association between cortisol ...
Fuchs Lior - - 2012
PURPOSE: The effect of advanced age per se versus severity of chronic and acute diseases on the short- and long-term survival of older patients admitted to the intensive care unit (ICU) remains unclear. METHODS: Intensive care unit admissions to the surgical ICU and medical ICU of patients older than 65 years were ...
Li Qinghong - - 2012
Aging hallmarks include decreased progenitor cell functions. The Wnt/β-catenin signaling pathway has emerged as a key player in cellular aging in recent years. Wnt activity changes in aged tissues including skin, serum, muscle and artery. In heart, it is hypothesized that Wnt signaling increases with aging and this signaling drives ...
Stein Gideon Y - - 2012
The prevalence of heart failure (HF) among hospitalized elderly patients is high and steadily growing. However, because most studies have focused mostly on young patients, little is known about the clinical characteristics, echocardiographic measures, prognostic factors, and outcome of hospitalized elderly HF patients. We identified all HF patients aged ≥50 ...
Daniels Karla M - - 2012
Cardiac rehabilitation improves function and compliance and also reduces morbidity and mortality in female and male cardiovascular disease patients but remains significantly underutilized. At every age, and especially in their senior years, female cardiovascular disease patients are under-referred relative to men. Lack of standardized referral processes, misconceptions by physicians and ...
Kutty Shelby - - 2012
BACKGROUND: -Cardiac magnetic resonance imaging (CMR) is an important clinical tool for serial follow-up of patients with congenital heart disease, but normative data for great vessel dimensions in pediatric subjects are scarce. We investigated ascending aortic (AO) and main pulmonary artery (MPA) dimensions in normal children and young adults in ...
Koestenberger Martin - - 2012
Longitudinal myocardial function has gained more interest in the last years. The mitral annular plane systolic excursion (MAPSE) is an echocardiographic measurement to assess left ventricular (LV) long-axis function in adults. The aim of this study was to evaluate MAPSE values in a healthy pediatric population and to propose reference ...
Sangaralingham S Jeson - - 2012
Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The ...
Ristić Arsen D - - 2012
The epicardial halo delineates the heart shadow in fluoroscopy. To establish whether the sign is applicable to pericardiocentesis guidance, three investigators evaluated its intensity as absent = grade 0, indistinct = 0.5, clear = 1, intensive = 2 in posterior-anterior (PA) and lateral fluoroscopies recorded before pericardiocentesis or cardiac catheterization (Philips Integris-II BH3000). Three populations were studied: (a) ...
Aro Aapo L - - 2012
BACKGROUND: T-wave inversion in right precordial leads V(1)-V(3) is a relatively common finding in a 12-lead electrocardiogram (ECG) of children and adolescents and is infrequently found also in healthy adults. However, this ECG pattern can also be the first presentation of arrhythmogenic right ventricular cardiomyopathy (ARVC). The prevalence and prognostic ...
McNarry M A - - 2012
Heart rate variability (HRV) and phase-rectified signal averaging (PRSA) estimates of heart rate dynamics are diminished in older people compared with younger people. However, it is not fully elucidated whether these differences are related to age per se or to the concomitant influence of aerobic fitness. Aerobic fitness (peak oxygen ...
Noci B - - 2012
Growth, gravidity and lactation put high demands on the performance of the myocardium. The aim of this study, which was performed in 40 female and 20 male bovines ranging from 1 to 4.5 years old, was to determine gross and microscopic morphometric data of bovine myocardium to establish a comparative measure ...
Saleem Shemaila - - 2012
To identify the basic values of heart rate variability in Pakistani population and to verify our hypothesis that there are gender differences in cardiovascular autonomic modulation. The descriptive cross sectional study based on convenience probability sampling was conducted at Armed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD) Pakistan. ...
Moslehi Javid - - 2012
Studies in humans and in mice have highlighted the importance of short telomeres and impaired mitochondrial function in driving age-related functional decline in the heart. Although telomere and mitochondrial dysfunction have been viewed mainly in isolation, recent studies in telomerase-deficient mice have provided evidence for an intimate link between these ...
Dai Dao-Fu DF Department of Pathology, University of Washington, Seattle, - - 2012
Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of mitochondria both in lifespan determination and in cardiovascular aging. In this article we review the evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and ...
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