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Serban Andreea Iren AI Department of Preclinical Sciences, University of Agronomical Sciences and Veterinary Medicine, 105 Splaiul Independentei, 050097, Bucharest, - - 2014
Interstitial fibrosis is induced by imbalances in extracellular matrix homeostasis. Advanced glycation end products (AGEs) can bind and activate the receptor for AGEs (RAGE), which is involved in diabetic nephropathy. We set out to identify the role of AGEs in producing alterations leading to matrix hypertrophy and the pathway through ...
Nguyen The Thuong TT MéDIAN Biophotonique et Technologies pour la Santé, CNRS FRE 3481 MEDyC, SFR Cap-Santé, UFR Pharmacie, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51096 Reims Cedex, France. - - 2014
During chronological skin aging, alterations in dermal structural proteins cause morphological modifications. Modifications are probably due to collagen fiber (type I collagen) rearrangement and reorientation with aging that have not been researched until now. FTIR microspectroscopy appears as an interesting method to study protein structure under normal and pathological conditions. ...
Qian Feng F Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, - - 2014
Aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. Here we show reduced expression of Toll-like receptor 1 (TLR1) in polymorphonuclear leukocytes (PMN) and an underlying age-dependent deficiency in PMN bioenergetics. In older (>65 years) adults, stimulation through ...
Kim Hee Kyung HK 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH - - 2014
OBJECTIVE. T2 relaxation times on MRI are sensitive to the configuration of cartilage collagen and continually increase during aging in adults. In children, T2 relaxation times increase as a result of cartilage microstructure changes in early inflammatory arthritis. The purpose of this study was to determine age- and sex-related differences ...
Aslam Imran I From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, - - 2014
To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function. Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure ...
Chang P-C PC Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, - - 2014
The blocking of advanced glycation end-products (AGE) has been shown to reduce diabetic complications and control periodontitis. This study investigated the pattern of palatal wound-healing after graft harvesting under the administration of aminoguanidine (AG), an AGE inhibitor, or N-phenacylthiazolium bromide (PTB), a glycated cross-link breaker. Full-thickness palatal excisional wounds (5.0 ...
Sokolis Dimitrios P DP Laboratory of Biomechanics, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Electronic address: - - 2014
We hypothesized that female gender may have a specific negative impact on the mechanical characteristics, composition, and expression of matrix metalloproteinases/tissue inhibitors (MMPs/TIMPs) in the wall of ascending thoracic aortic aneurysms (ATAAs). Degenerative ATAAs were resected from 35 patients (age: 67±2 years, male: 20, ATAA diameter: 5.5±0.1cm) undergoing elective surgery. ...
Kutlu Haytoglu N S NS Department of Dermatology, Istanbul Education and Research Hospital, Istanbul, - - 2014
Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy. The sun-exposed malar area, the anterior aspect of ear lobule, and the sun-protected posterior ...
Plate Johannes F JF Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, NC, - - 2014
BACKGROUND:Advanced patient age is associated with recurrent tearing and failure of rotator cuff repairs clinically; however, basic science studies have not evaluated the influence of aging on tendon-to-bone healing after rotator cuff repair in an animal model.Hypothesis/ PURPOSE:This study examined the effect of aging on tendon-to-bone healing in an established ...
Langton A K AK Centre for Dermatology, Salford Royal NHS Foundation - - 2014
Geographical ancestry plays a key role in determining the susceptibility of human skin to external insults and dermatological disease. Despite this, studies of human skin using individuals of diverse geographic ancestry primarily focus on epidermal pigmentation, with few reports characterising the underlying biology of the dermis and dermal-epidermal junction (DEJ) ...
Francin Pierre-Jean PJ UMR 7365 CNRS-Universite de Lorraine, Biopôle de l'Universite de Lorraine, campus Biologie-Sante, Avenue de la forêt de Haye, BP 184, 54505 Vandoeuvre-les-Nancy, France. Electronic address: - - 2014
Conflicting findings raise questions about the role of adiponectin in osteoarthritis (OA). The current study aimed to investigate in OA patients the association between the production of adiponectin and the grade of cartilage destruction, and to provide functional evidence for a potential role of adiponectin in OA. The expression of ...
Corbin Zachary A ZA Department of Neurology, Massachusetts General Hospital, Boston, - - 2014
White matter hyperintensity (WMH), a common radiographic finding associated with stroke risk and outcome, has been linked to matrix metalloproteinase (MMP) activity and increased levels of oxidative stress in nonstroke populations. We sought to determine whether WMH severity is associated with plasma levels of MMPs and oxidative stress (F2-isoprostane) in ...
Calvi E N C EN Division of Plastic Surgery, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 715, 4o. andar, São Paulo, SP, 04023-062, - - 2014
To assess collagen content and types in the rectus abdominis muscle of cadavers of different ages. Forty fresh adult male cadavers within 24 h of death were obtained from an Institute of Legal Medicine and divided by age at death into Group 1 (mean age, 23.3 years; range, 18-30 years; n = 20) and Group ...
Tsai Sheng-Chueh SC Institute of Molecular and Cellular Biology, College of Life Science, National Taiwan University, Taipei, - - 2014
Blockade of advanced glycation end-products (AGE) is able to reduce diabetic complications and control periodontitis. This study aimed to determine whether the application of aminoguanidine (AG), an AGE inhibitor, or N-phenacylthiazolium bromide (PTB), an AGE breaker, facilitates the healing of an osseous wound in non-diabetic animals. 2.6 mm diameter full-thickness ...
Luria Ayala A Department of Orthopaedic Surgery, Stanford School of Medicine, Stanford, - - 2014
Articular cartilage has a unique functional architecture capable of providing a lifetime of pain-free joint motion. This tissue, however, undergoes substantial age-related physiologic, mechanical, biochemical, and functional changes that reduce its ability to overcome the effects of mechanical stress and injury. Many factors affect joint function in the maturing athlete-from ...
Hinman Rana S RS Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Victoria, - - 2013
Objective: To document the prevalence of radiographic OA in the medial and lateral patellofemoral joint (PFJ) compartments relative to prevalence of tibiofemoral joint (TFJ) OA in middle-aged and older adults with chronic patellofemoral knee pain. Methods: A convenience sample of 224 people who volunteered for a clinical trial underwent weight-bearing ...
Nowotny Kerstin K Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University, Jena, - - 2013
Skin aging is a multifactorial process leading to structural and physiological changes.Protein modifications are known to play here an important role. Since collagen is the most abundant protein in the extracellular matrix of the skin and due to its slow turnover rates it is a frequent target of modifications by ...
Sunwoo Woong Sang - - 2013
IMPORTANCE Rib cartilage from the sixth, seventh, and eighth ribs offers a long cartilaginous curvature, making the material reliable for grafting. Calcification of cartilage causes unexpected absorption, difficult manipulation, and donor site morbidity. Most studies of calcification were performed in Western countries. OBJECTIVE To investigate the incidence, degree, and pattern ...
Fields Aaron J AJ Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, 513 Parnassus Avenue, S-1157, San Francisco, California, - - 2014
Endplate cartilage integrity is critical to spine health and is presumably impaired by deterioration in biochemical composition. Yet, quantitative relationships between endplate biochemical composition and biomechanical properties are unavailable. Using endplate cartilage harvested from human lumbar spines (six donors, ages 51-67 years) we showed that endplate biochemical composition has a ...
Lenskjold A - - 2013
Achilles tendinopathy is a highly prevalent sports injury. Animal studies show a growth response in tendons in response to loading in the immature phase but not after puberty maturation. The aim of this investigation was to examine the structural and material properties in long distance runners who were either physically ...
Kolozsvári Bence Lajos - - 2013
Purpose: To study the association between different types of mediators in the tear fluid and topographic indices characterizing the severity of keratoconus (KC). Methods: In this study, nonstimulated tear fluid samples were collected from 14 eyes of 11 patients with KC. The following indices were measured by corneal topography: maximum ...
Matzenauer Christian - - 2013
Age estimation based on aspartic acid racemization (AAR) has been applied successfully to various tissues. For routine uses, AAR is analyzed in dentine. For cases in which teeth are unavailable, analyzing AAR in purified elastin has been shown to be an alternative method. The suitability of elastic cartilage from the ...
Moghimi Nasrin - - 2013
This study aims to conduct an urban Community Oriented Program for Control Of Rheumatic Diseases (COPCORD) study in Sanandaj (Kurdistan, Iran). Sanandaj with a population of 311,446 (2006 census), Caucasian of Kurdish subgroup, was selected as the field. Sanandaj was divided into 100 clusters and subjects were randomly selected from ...
Miura Jiro J Division for Interdisciplinary Dentistry, Osaka University Dental Hospital, Japan. Electronic address: - - 2014
Cross-linking of collagen by Advanced Glycation End-products (AGEs) occurs by non-enzymatic glycation (Maillard reaction). The purpose of this study was to examine whether AGEs are formed in human dentinal collagen, and to consider any possible influence of AGEs on dentinal physiology. Mechanical characteristics, fluorescence spectra and immunohistochemical analyses of demineralized ...
Gray Kristen E - - 2013
Telomere length is a marker of cellular aging that varies with the individual, is inherited, and is highly correlated across somatic cell types within persons. Interindividual variability of telomere length may partly explain differences in reproductive aging rates. We examined whether leukocyte telomere length was associated with menopausal age. We ...
Vos Lukas M - - 2013
Most of the current understanding of articular cartilage maintenance and degradation is derived from large load-bearing synovial joints, in particular the knee joint. The aim of this study was to identify valuable degradation markers for cartilage degradation in the temporomandibular joint (TMJ) by comparing the relative concentrations of carboxyterminal telopeptides ...
Suvan J - - 2013
Body mass index (BMI) and obesity are associated with the prevalence, extent, and severity of periodontitis. This study investigated the predictive role of overweight/obesity on clinical response following non-surgical periodontal therapy in patients with severe periodontitis. Two hundred sixty adults received an intensive course of non-surgical periodontal therapy. Periodontal status ...
Staufenbiel Ingmar - - 2013
Marfan syndrome (MFS) is a disorder of the connective tissues. Alterations of the elastic fibers may manifest in different tissues especially in the skeletal, cardiovascular and ocular system. Oral manifestations like orthodontic or skeletal anomalies and fragility of the temporomandibular joint have been well described by various authors. However, no ...
Leaker Sarah Helen - - 2013
Old age, pressure ulcers and malnutrition may co-exist. Wounds in older people may already be slow to heal as a result of compromised skin integrity, which occurs as part of the normal ageing process. Malnutrition is also more common in older people, and evidence has shown that inadequate nutrition may ...
Chai Toby C - - 2013
Urinary biomarkers were measured from women at baseline and 1 post-surgery for stress urinary incontinence (SUI) and associations with clinicodemographic covariates and outcomes were analyzed. Pre- and post-surgery urine specimens from 150 women were assayed for inflammatory biomarkers (TNF-α, IFN-γ, IL-1β, IL6,IL10, IL12p70, IL17, NGF) and tissue remodeling biomarkers (collagenase ...
Paim Layde R - - 2013
Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role ...
Chang Jun - - 2013
The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that ...
Gentile Nicole M - - 2013
The increasing incidence of microscopic colitis has been partly attributed to detection bias. We aimed to ascertain recent incidence trends and the overall prevalence of microscopic colitis in a population-based study. Using data from the Rochester Epidemiology Project, we identified residents of Olmsted County, Minnesota who were diagnosed with collagenous ...
Marshall Michelle - - 2013
To determine whether erosive osteoarthritis shares the same pattern of joint involvement and risk profile as increasing grades of non-erosive hand osteoarthritis. Participants were from two population-based cohorts, aged ≥50 years, reporting hand symptoms in the previous month. Interphalangeal joints were assessed for erosive osteoarthritis (Verbruggen-Veys erosive or remodelled phase) ...
Jiang Rui - - 2013
With aging, the human fracture risk gradually increase. This is mainly due to the corresponding changes of the biomechanical parameters of human bone presents with aging. We measured the microstructural parameters of lumbar bone from women in several age groups by micro-computed tomography and scanning electron microscopy. We observed changes ...
Swami Viren - - 2013
This study examined skin tone dissatisfaction, measured using a skin tone chart, among a multiethnic sample of British adults. A total of 648 British White individuals, 292 British South Asians, and 260 British African Caribbean participants completed a visual task in which they were asked to indicate their actual and ...
Dev Yash Paul YP Professor and Head, Department of Periodontics, Swami Devi Dayal Hospital and Dental College , India - - 2013
Aim: To determine whether there is a relationship between periodontal disease and rheumatoid arthritis. Methods: A total of 1520 (852 - periodontal group; 668 - general group) individuals of 30-70 years age group and residents of Baddi industrial estate in Himachal Pradesh, India, were assessed for the prevalence of rheumatoid ...
Pawlaczyk Mariola M Department of Geriatrics and Gerontology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Mariola Pawlaczyk MD, - - 2013
The skin fulfills one of its most important functions, that is protection from mechanical injuries, due to the mechanism of reversible deformation of the structure. Human skin is a complex living material but in biomechanical tests it reveals its homogeneous nature. Biomechanical skin parameters change with time. Results of thickness ...
Liutkeviciene Rasa - - 2013
Abstract Background: Matrix metalloproteinases (MMP) are responsible for the degradation of extracellular matrix components and play an important role in the physiological and pathological remodeling of tissues. Purpose: To assess the impact of MMP-2 Rs2285053 (C -> T), MMP-3 Rs3025039 (5A -> 6A), and MMP-9 Rs3918242 (C -> T) single nucleotide polymorphism on the development of ...
Gautieri Alfonso - - 2013
Ageing and diabetes share a common deleterious phenomenon, the formation of Advanced Glycation Endproducts (AGEs), which accumulate predominantly in collagen due to its low turnover. Though the general picture of glycation has been identified, the detailed knowledge of which collagen amino acids are involved in AGEs is still missing. In ...
Wilson Samantha L - - 2013
During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic and macroscopic properties of different-aged collagens from newborn to 2-yr-old rats, to examine the effect of aging on fibrillogenesis, ...
Farwick M - - 2013
Background: Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production. Here, their effects on cutaneous aging by means of objective instrumental measurements were elucidated. Methods: Reconstituted human epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of various ...
Radlović Vladimir V University Children's Hospital, Belgrade, Serbia. - - 2013
Pseudoachondroplasia (PSACH) is an autosomal dominant osteochondrodysplasia due to mutations in the gene encoding cartilage oligomeric matrix protein. It is characterized by rhizomelic dwarfism, limb and vertebral deformity, joint laxity and early onset osteoarthrosis. We present the girl with the early expressed and severe PSACH born to clinically and radiographically ...
Wilcox James R JR Healogics, Jacksonville, - - 2013
Chronic wounds usually get trapped in the inflammatory stage of wound healing; however, aggressive debridement transforms chronic wounds to acute wounds and therefore complete healing. To investigate healing outcomes and debridement frequency in a large wound data set. Retrospective cohort study. Data collected from 525 wound care centers from June ...
Krieger Elena - - 2013
Recently, research has focused intensely on age-related tissue changes, not only in the field of dermatology but also in dental sciences. Although many new insights into age-related morphological, ultrastructural and biochemical changes in the periodontal ligament tissue have been gained, the basic question of whether there is a quantitative change ...
Vafaie Faran - - 2013
Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r) ) that yields collagenase-resistant type I collagen. Compared to wild-type littermates, Col1a1(r/r) mice ...
Wickbom Anna - - 2013
The incidence of microscopic colitis (MC) has increased in several centers, but long-term epidemiologic data are missing. We report an epidemiologic study of collagenous colitis (CC) and lymphocytic colitis (LC) during 1999-2008, as a follow-up of our previous studies 1984-1998. Population-based study of residents of the catchment area of the ...
Li Yong - - 2013
Proteoglycans, a family of glycosaminoglycan (GAG) conjugated proteins, are important constituents of human skin connective tissue (dermis) and are essential for maintaining mechanical strength of the skin. Age-related alterations of dermal proteoglycans have not been fully elucidated. We quantified transcripts of 20 known interstitial proteoglycans in human skin and found ...
Vos Lukas M - - 2013
There is a growing interest in markers for cartilage degradation in synovial joints because of their potential diagnostic and prognostic value. Therefore, the aim of this study was to identify valuable degradation markers for temporomandibular joint (TMJ) osteoarthritis (OA) by comparing the relative concentrations of carboxyterminal telopeptides type I and ...
Hashimoto Ichiro - - 2013
Coccygeal pad is a nodular lesion in the sacrococcygeal area, typically involving a proliferation of collagen bundles. The etiology and optimal treatment remain unclear. We investigated the etiology using a systematic review of the available published work, two cases that we examined and treated, and measurements of body pressure in ...
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