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Sivan Sarit Sara SS Department of Biotechnology Engineering, ORT Braude College, Karmiel 21982 Israel. Electronic address: - - 2014
Aggrecan is the major non-collagenous component of the intervertebral disc. It is a large proteoglycan possessing numerous glycosaminoglycan chains and the ability to form aggregates in association with hyaluronan. Its abundance and unique molecular features provide the disc with its osmotic properties and ability to withstand compressive loads. Degradation and ...
Zorel Valdenilson José VJ Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário, 13607-339, Araras, SP, - - 2014
The plantaris longus tendon (PLT) in bullfrog develops a fibrocartilage-like tissue in the area that is functionally subject to compressive forces. The aim of this study was to analyze the modifications of the pressure-bearing region in bullfrog PLT with different ages (7, 180, and 1,080 days after the end of ...
Musumeci G G Department of Bio-Medical Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, - - 2014
Osteoarthritis (OA) is a common musculoskeletal disorder characterized by slow progression and joint tissue degeneration. Aging is one of the most prominent risk factors for the development and progression of OA. OA is not, however, an inevitable consequence of aging and age-related changes in the joint can be distinguished from ...
Damodarasamy Mamatha M Department of Medicine, University of Washington, Seattle, - - 2014
Age-related changes in the extracellular matrix contribute to delayed wound repair in aging. Hyaluronan, a linear nonsulfated glycosaminoglycan, promotes synthesis and assembly of key extracellular matrix components, such as the interstitial collagens, during wound healing. The biological effects of hyaluronan are mediated, in part, by hyaluronan size. We have previously ...
Milenkovic Petar P Laboratory for Anthropology, Institute of Anatomy, School of Medicine, University of Belgrade, 4/2 Dr Subotica, 11000, Belgrade, - - 2014
The ossification patterns of medial clavicle and the first costal cartilage represent interesting features of the same anatomical region which are accessible for conventional radiographic and computed tomography (CT) examinations in the same field of view. This study encompassed Serbian population and was carried out to examine whether CT analyses ...
Kwok Jeanie J Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093; Department of Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093; Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA - - 2014
With aging, the menisci become more susceptible to degeneration due to sustained mechanical stress accompanied by age-related changes in the extracellular matrix (ECM). However, the mechanistic relationship between age-related meniscal degeneration and osteoarthritis (OA) development is not yet fully understood. We have examined the nanomechanical properties of the ECM of ...
Yamaguchi Ryosuke R Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis (RDA) and developmental dysplasia of the hip (DDH). We studied ...
Yen A M-F AM School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan - - 2014
Periodontal disease and colorectal cancer have inflammatory processes in common. It is therefore worthwhile to investigate whether there is an association between periodontal probing depth and fecal hemoglobin concentration (FHbC), an indicator of colorectal neoplasms, in 40- to 44-year-old Taiwanese. We enrolled a total of 6,214 attendees aged 40 to ...
Lim W H WH Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, 94305, USA; Department of Orthodontics, School of Dentistry & Dental Research Institute, Seoul National University, Seoul, - - 2014
Many in vitro studies have investigated age-related biological changes in cells comprising the periodontium but the basic question of whether the periodontium can maintain its integrity with age remains unanswered. Thus, the aim of this study was to understand how, in the absence of disease, advancing age impacts the structure ...
Freedman Jane E JE University of Massachusetts Medical School, Worcester, MA - - 2014
The most common arrhythmia in older adults is atrial fibrillation with an estimated prevalence of approximately 9% in adults aged 80 years or older and a concomitant increased burden of developing stroke. Additionally, over the past decade, both the incidence and prevalence of atrial fibrillation has markedly increased(1) and, with ...
Xu Haidong H Department of Orthopedics, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, 305 Zhongshan East Road, Nanjing, 210002, - - 2014
Matrix metalloproteinases (MMPs) have been known to play a pivotal role in the age- and/or disease-related degradation of intervertebral discs. We aimed to explore as to whether the expression of these enzymes is correlated to disc degeneration caused by increasing age and severity of herniation in the East Asian population. ...
Nikulshin S S Clinical Laboratory, Children's Clinical University Hospital, Riga, - - 2014
Myeloperoxidase (MPO) is an enzyme produced by neutrophil leukocytes and released upon activation, killing pathogens and causing tissue damage. As neutrophils in neonates are functionally immature, cellular MPO content in children may be age-related and different from adults. Hematological analyzer ADVIA 2120i (Siemens AG), while routinely assessing neutrophil count, measures ...
Puri Archana A Department of Pediatric Surgery, Lady Hardinge Medical College, New Delhi, India. Electronic address: - - 2014
To evaluate bladder growth after combined bladder and epispadias repair (CBER) in children aged 5-years or more, and to correlate their bladder histology with final surgical outcome. We prospectively evaluated eight late bladder exstrophy (BE) referrals, within a series of 26 patients, managed over a study period of 5 years. ...
Tomei Ernesto - - 2014
To evaluate bone age determination using MRI of the hand and wrist. A total of 179 (78 female and 101 males, 11 to 16 years old) subjects of 252 normal volunteers met entrance criteria. A low field open magnet (0.2 Tesla) was used for this study; coronal T1-weighted images with ...
Hazeldine Jon J MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Immunity and Infection, Birmingham University Medical School, Birmingham, B15 2TT, - - 2014
Neutrophil extracellular traps (NETs) are a recently discovered addition to the defensive armamentarium of neutrophils, assisting in the immune response against rapidly dividing bacteria. Although older adults are more susceptible to such infections, no study has examined whether aging in humans influences NET formation. We report that TNF-α-primed neutrophils generate ...
Eckstein Felix F Instituts of Anatomy, Paracelsus Medical University, Salzburg, Austria & Chondrometrics GmbH, Ainring, Germany. Electronic address: - - 2014
Knee replacement (KR) represents a clinically important endpoint of knee osteoarthritis (KOA). Here we examine the four-year trajectory of femoro-tibial cartilage thickness loss prior to KR vs. non-replaced controls. A nested case-control study was performed in Osteoarthritis Initiative (OAI) participants: Cases with KR between 12-60 month (M) follow-up were each ...
Souza Richard B RB Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA. Electronic address: - - 2014
The objective of this study was to evaluate the effects of mechanical loading on knee articular cartilage T1ρ and T2 relaxation times in patients with and without OA. MR images were acquired from 137 subjects with and without knee OA under two conditions: unloaded and loaded at 50% body weight. ...
Cáceres M M Molecular and Cell Biology Program, Facultad de Medicina, Universidad de Chile, Santiago, - - 2014
Aging may negatively affect gingival wound-healing. However, little is known about the mechanisms underlying this phenomenon. The present study examined the cellular responses associated with gingival wound-healing in aging. Primary cultures of human gingival fibroblasts were obtained from healthy young and aged donors for the analysis of cell proliferation, cell ...
Ishida Masanori M *Department of Radiology, Graduate School of Medicine, The University of Tokyo; †Department of Radiology, Mutual Aid Association for Tokyo Metropolitan Teachers and Officials, Sanraku Hospital; and ‡Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, - - 2014
To evaluate radiographic features of endotracheal/endobronchial fluid in the airway (FA) observed on postmortem computed tomography (PMCT). We studied 164 subjects who died at our hospital between April 2009 and September 2012. Fluid in the airway was considered positive when fluid was identified in the lumen of 1 of the ...
Bentov Itay I Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington, Box 359724, 325 Ninth Avenue, Seattle, WA, 98104, USA, - - 2014
Skin aging results in increased susceptibility to injury and impaired wound healing. Proliferation of fibroblasts is reduced in aged dermis, which contributes to delays in wound closure. Age-associated differences are regulated, in part, by local or systemic factors such as the IGF-1/IGF1R system. The aim of this study was to ...
Montevecchi M M Department of Periodontology, University of Bologna, Bologna, - - 2014
In this study we investigated periodontal healing of mandibular second molars following 'orthodontic extraction' of adjacent impacted third molars, under the null hypothesis that there would be no difference in probing pocket depths (PPD) and clinical attachment levels (CAL) at the distal aspect of second molars before and after treatment. ...
Marcos-Garcés V V Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, - - 2014
The tissue organisation of dermal collagen is gaining importance as a contributing factor both in development and ageing, as well as in skin maturation processes. In this work we aim to study different representative parameters of this structural organisation in 45 human skin samples of assorted ages, by means of ...
Serban Andreea Iren AI Department of Preclinical Sciences, University of Agronomical Sciences and Veterinary Medicine, 105 Splaiul Independentei, 050097, Bucharest, - - 2014
Interstitial fibrosis is induced by imbalances in extracellular matrix homeostasis. Advanced glycation end products (AGEs) can bind and activate the receptor for AGEs (RAGE), which is involved in diabetic nephropathy. We set out to identify the role of AGEs in producing alterations leading to matrix hypertrophy and the pathway through ...
Nguyen The Thuong TT MéDIAN Biophotonique et Technologies pour la Santé, CNRS FRE 3481 MEDyC, SFR Cap-Santé, UFR Pharmacie, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51096 Reims Cedex, France. - - 2014
During chronological skin aging, alterations in dermal structural proteins cause morphological modifications. Modifications are probably due to collagen fiber (type I collagen) rearrangement and reorientation with aging that have not been researched until now. FTIR microspectroscopy appears as an interesting method to study protein structure under normal and pathological conditions. ...
Qian Feng F Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, - - 2014
Aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. Here we show reduced expression of Toll-like receptor 1 (TLR1) in polymorphonuclear leukocytes (PMN) and an underlying age-dependent deficiency in PMN bioenergetics. In older (>65 years) adults, stimulation through ...
Kim Hee Kyung HK 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH - - 2014
OBJECTIVE. T2 relaxation times on MRI are sensitive to the configuration of cartilage collagen and continually increase during aging in adults. In children, T2 relaxation times increase as a result of cartilage microstructure changes in early inflammatory arthritis. The purpose of this study was to determine age- and sex-related differences ...
Aslam Imran I From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, - - 2014
To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function. Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure ...
Pivatto Júnior Fernando - - 2014
Objective: This study aims to describe the correlation between age and occurrence of atrial fibrillation after aortic stenosis surgery in the elderly as well as evaluate the influence of atrial fibrillation on the incidence of strokes, hospital length of stay, and hospital mortality. Methods: Cross-sectional retrospective study of > 70 ...
Chang P-C PC Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, - - 2014
The blocking of advanced glycation end-products (AGE) has been shown to reduce diabetic complications and control periodontitis. This study investigated the pattern of palatal wound-healing after graft harvesting under the administration of aminoguanidine (AG), an AGE inhibitor, or N-phenacylthiazolium bromide (PTB), a glycated cross-link breaker. Full-thickness palatal excisional wounds (5.0 ...
Sokolis Dimitrios P DP Laboratory of Biomechanics, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Electronic address: - - 2014
We hypothesized that female gender may have a specific negative impact on the mechanical characteristics, composition, and expression of matrix metalloproteinases/tissue inhibitors (MMPs/TIMPs) in the wall of ascending thoracic aortic aneurysms (ATAAs). Degenerative ATAAs were resected from 35 patients (age: 67±2 years, male: 20, ATAA diameter: 5.5±0.1cm) undergoing elective surgery. ...
Kutlu Haytoglu N S NS Department of Dermatology, Istanbul Education and Research Hospital, Istanbul, - - 2014
Increased interest in antiaging methods, mandates a development of reliable noninvasive technique to assess skin aging. In this study, we aimed to determine the effects of photoaging at histopathologic resolution by means of reflectance confocal microscopy. The sun-exposed malar area, the anterior aspect of ear lobule, and the sun-protected posterior ...
Plate Johannes F JF Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, NC, - - 2014
BACKGROUND:Advanced patient age is associated with recurrent tearing and failure of rotator cuff repairs clinically; however, basic science studies have not evaluated the influence of aging on tendon-to-bone healing after rotator cuff repair in an animal model.Hypothesis/ PURPOSE:This study examined the effect of aging on tendon-to-bone healing in an established ...
Langton A K AK Centre for Dermatology, Salford Royal NHS Foundation - - 2014
Geographical ancestry plays a key role in determining the susceptibility of human skin to external insults and dermatological disease. Despite this, studies of human skin using individuals of diverse geographic ancestry primarily focus on epidermal pigmentation, with few reports characterising the underlying biology of the dermis and dermal-epidermal junction (DEJ) ...
Francin Pierre-Jean PJ UMR 7365 CNRS-Universite de Lorraine, Biopôle de l'Universite de Lorraine, campus Biologie-Sante, Avenue de la forêt de Haye, BP 184, 54505 Vandoeuvre-les-Nancy, France. Electronic address: - - 2014
Conflicting findings raise questions about the role of adiponectin in osteoarthritis (OA). The current study aimed to investigate in OA patients the association between the production of adiponectin and the grade of cartilage destruction, and to provide functional evidence for a potential role of adiponectin in OA. The expression of ...
Corbin Zachary A ZA Department of Neurology, Massachusetts General Hospital, Boston, - - 2014
White matter hyperintensity (WMH), a common radiographic finding associated with stroke risk and outcome, has been linked to matrix metalloproteinase (MMP) activity and increased levels of oxidative stress in nonstroke populations. We sought to determine whether WMH severity is associated with plasma levels of MMPs and oxidative stress (F2-isoprostane) in ...
Calvi E N C EN Division of Plastic Surgery, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 715, 4o. andar, São Paulo, SP, 04023-062, - - 2014
To assess collagen content and types in the rectus abdominis muscle of cadavers of different ages. Forty fresh adult male cadavers within 24 h of death were obtained from an Institute of Legal Medicine and divided by age at death into Group 1 (mean age, 23.3 years; range, 18-30 years; n = 20) and Group ...
Tsai Sheng-Chueh SC Institute of Molecular and Cellular Biology, College of Life Science, National Taiwan University, Taipei, - - 2014
Blockade of advanced glycation end-products (AGE) is able to reduce diabetic complications and control periodontitis. This study aimed to determine whether the application of aminoguanidine (AG), an AGE inhibitor, or N-phenacylthiazolium bromide (PTB), an AGE breaker, facilitates the healing of an osseous wound in non-diabetic animals. 2.6 mm diameter full-thickness ...
Luria Ayala A Department of Orthopaedic Surgery, Stanford School of Medicine, Stanford, - - 2014
Articular cartilage has a unique functional architecture capable of providing a lifetime of pain-free joint motion. This tissue, however, undergoes substantial age-related physiologic, mechanical, biochemical, and functional changes that reduce its ability to overcome the effects of mechanical stress and injury. Many factors affect joint function in the maturing athlete-from ...
Gonçalves Rogério De Oliveira Rde O Unifoa, Volta Redonda, Rio de Janeiro, - - 2014
to evaluate the role of fibrillar extracellular matrix components in the pathogenesis of inguinal hernias. samples of the transverse fascia and of the anterior sheath of the rectus abdominis muscle were collected from 40 men aged between 20 and 60 years with type II and IIIA Nyhus inguinal hernia and ...
Little Dianne D Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, United States of - - 2014
The risk of anterior cruciate ligament (ACL) injury and re-injury is greater for women than men. Among other factors, compositional differences may play a role in this differential risk. Patellar tendon (PT) autografts are commonly used during reconstruction. The aim of the study was to compare protein expression in male ...
Labat-Robert J J Hotel-Dieu Hospital, Paris V University, Paris, - - 2014
In this chapter, we describe in detail the age-dependent modifications of connective tissues, separately for their cellular and extracellular compartments. Cell aging was studied by the in vitro method established by Hayflick as well as by ex vivo explant cultures, and results with both methods are discussed. Follows then the ...
van der Kraan Peter M PM Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The - - 2014
Age is the most important risk factor for primary osteoarthritis (OA). Members of the TGF-β superfamily play a crucial role in chondrocyte differentiation and maintenance of healthy articular cartilage. We have investigated whether age-related changes in TGF-β superfamily signaling components play a role in the relationship between OA-related cartilage degradation ...
Hanada Michiko M Faculty of Animal Health Technology, Department of Animal Health Technology, Yamazaki Gakuen University, Tokyo 150-0046, - - 2014
Uteri from 50 necropsied nonpregnant Japanese Thoroughbred brood mares (1-30 years of age) were investigated to clarify the histopathological characteristics of endometrosis in Japanese Thoroughbred mares and the distribution pattern of endometrosis lesions in the uterus as a whole. Endometrosis was observed in all animals over 6 years of age ...
Herrero Carlos Fernando P S CF Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, - - 2014
Endplate separations are defined as the presence of a space between the hyaline cartilage and the cortical bone of the adjacent vertebral body. This study evaluates endplate separations from the vertebral body and intervertebral discs and verifies if endplate separation is related to age and the spinal level. Groups were ...
Wan Chao C State Key Laboratory of Tribology, Tsinghua University, Beijing, - - 2014
The mechanical properties of ligaments are key contributors to the stability and function of musculoskeletal joints. Ligaments are generally composed of ground substance, collagen (mainly type I and III collagen), and minimal elastin fibers. However, no consensus has been reached about whether the distribution of different types of collagen correlates ...
Bradke Brian S BS Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, United States of - - 2014
Nonenzymatic glycation (NEG) describes a series of post-translational modifications in the collagenous matrices of human tissues. These modifications, known as advanced glycation end-products (AGEs), result in an altered collagen crosslink profile which impacts the mechanical behavior of their constituent tissues. Bone, which has an organic phase consisting primarily of type ...
Hinman Rana S RS Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Victoria, - - 2013
Objective: To document the prevalence of radiographic OA in the medial and lateral patellofemoral joint (PFJ) compartments relative to prevalence of tibiofemoral joint (TFJ) OA in middle-aged and older adults with chronic patellofemoral knee pain. Methods: A convenience sample of 224 people who volunteered for a clinical trial underwent weight-bearing ...
Nowotny Kerstin K Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University, Jena, - - 2013
Skin aging is a multifactorial process leading to structural and physiological changes.Protein modifications are known to play here an important role. Since collagen is the most abundant protein in the extracellular matrix of the skin and due to its slow turnover rates it is a frequent target of modifications by ...
Sunwoo Woong Sang - - 2013
IMPORTANCE Rib cartilage from the sixth, seventh, and eighth ribs offers a long cartilaginous curvature, making the material reliable for grafting. Calcification of cartilage causes unexpected absorption, difficult manipulation, and donor site morbidity. Most studies of calcification were performed in Western countries. OBJECTIVE To investigate the incidence, degree, and pattern ...
Fields Aaron J AJ Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, 513 Parnassus Avenue, S-1157, San Francisco, California, - - 2014
Endplate cartilage integrity is critical to spine health and is presumably impaired by deterioration in biochemical composition. Yet, quantitative relationships between endplate biochemical composition and biomechanical properties are unavailable. Using endplate cartilage harvested from human lumbar spines (six donors, ages 51-67 years) we showed that endplate biochemical composition has a ...
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