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Results 251 - 300 of 1057
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Loeser Richard F - - 2011
Osteoarthritis is strongly linked to aging but the mechanisms for this link are incompletely understood. The recent literature was reviewed to find studies providing new insights into the connection between aging and osteoarthritis. Basic aging studies in nonarticular cells suggest that a cell stress or cell damage response contributes to ...
Cano-Pumarega Irene - - 2011
RATIONALE: Obstructive sleep apnea (OSA) and systemic hypertension (SH) are highly prevalent. Although their association has been suggested in cross-sectional studies, conflicting evidence has emerged from longitudinal studies. OBJECTIVES: To assess the association between OSA and SH in the middle-aged general population. METHODS: We included 2,148 subjects in a longitudinal ...
Singh Rumani - - 2012
Lifelong dietary restriction (DR) is known to have many potential beneficial effects on brain function as well as delaying the onset of neurological diseases. In the present investigation, the effect of late-onset short-term intermittent fasting dietary restriction (IF-DR) regimen was studied on motor coordination and cognitive ability of ageing male ...
Pan Yong - - 2011
As a major intracellular source of reactive oxygen species (ROS), mitochondria are involved in aging and lifespan regulation. Using the yeast chronological aging model, researchers have identified conserved signaling pathways that affect lifespan by modulating mitochondrial functions. Caloric restriction and a genetic mimetic with reduced target of rapamycin signaling globally ...
Patel Molini M MM Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, College of Physicians and Surgeons, 630 W. 168th St, NY 10032, - - 2011
Exposures to ambient air traffic-related pollutants and their sources have been associated with respiratory and asthma morbidity in children. However, longitudinal investigation of the effects of traffic-related exposures during early childhood is limited. We examined associations of residential proximity and density of traffic and stationary sources of air pollution with ...
Monaghan Pat - - 2012
Stressful conditions early in life can give rise to exaggerated stress responses, which, while beneficial in the short term, chronically increase lifetime exposure to stress hormones and elevate disease risk later in life. Using zebra finches Taeniopygia guttata, we show here that individuals whose glucocorticoid stress hormones were experimentally increased ...
Ahn Ji Hyeon - - 2011
We previously reported that no distinct neuronal loss occurred in the aged dog spinal cord, although oxidative stress was increased in the aged dog spinal cord. Thioredoxin 2 (Trx2)/peroxiredoxin 3 (Prx3) redox system is a major route for removing H(2)O(2) in the central nervous system. In the present study, we ...
Guevara Rocío - - 2011
Mitochondria are the main source of free radical species and the most direct target for their damaging effects, which especially affect the brain mitochondrial function, which is better maintained by females than males. The aim of this work was to investigate the age-related changes in rat brain mitochondrial oxidative status ...
Hekimi Siegfried S Department of Biology, McGill University, Montréal, Canada H3A 1B1. - - 2011
The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based on the observed association of the rate of aging and the aged phenotype with the generation of ROS and oxidative damage. However, recent findings, ...
Lee Jae-Eun - - 2011
Even though CR has shown to enhance base excision repair (BER) and nucleotide excision repair (NER) capacities, it has not been reported whether CR can enhance non-homologous end joining (NHEJ) activity. To examine the effect of CR on NHEJ activity, ad libitum (AL)- and calorie restricted (CR)-dieted rats were used. ...
Kuhla Angela - - 2011
The objective of this study is to clarify whether age-related oxidative stress enhances hepatic vulnerability via increased interaction of advanced glycation endproducts (AGE) with their receptor RAGE. To further address the role of uncoupling of mitochondrial respiration, mitochondrial uncoupling protein-2 wild-type (UCP2+/+) and knock out (UCP2-/-) mice were used and ...
Tomobe Koji - - 2011
SAMP8 mice show spontaneously accelerated aging and a short life span with systemic accumulation of oxidative stress. Nrf2 translocates into the nucleus upon oxidative stress and induces the expression of detoxifying and antioxidant enzymes. Recently, several studies reported that Nrf2 is associated with aging and various diseases. In the present ...
Yut Iliya - - 2011
Oxidative age hardening of bitumen results in increasing fatigue susceptibility of bituminous mixtures, thus reducing the service life of asphalt pavements. Polymer additives to bitumen have been shown to improve its viscoelastic properties and, in some cases, reduce the level of bitumen hardening. Fourier transform infrared (FT-IR) spectroscopy enables evaluation ...
Serviddio Gaetano - - 2011
Aging is a physiologic state in which a progressive decline of organ functions may be accompanied by developing age-related diseases and neurodegenerative diseases. The causes of such conditions remain unknown, being probably related to a multifactor process. To date, the Free Radical and Mitochondrial theories seem to be the two ...
Bell Eric L - - 2011
Sirtuins are NAD(+) dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 ...
Musicco Clara - - 2011
Oxidative stress has a central role in aging and in several age-linked diseases such as neurodegenerative diseases, diabetes and cancer. Mitochondria, as the main cellular source and target of reactive oxygen species (ROS) in aging, are recognized as very important players in the above reported diseases. Impaired mitochondrial oxidative phosphorylation ...
Kowald Axel - - 2011
Mitochondria are organelles of eukaryotic cells that contain their own genetic material and evolved from prokaryotic ancestors some 2 billion years ago. They are the main source of the cell's energy supply and are involved in such important processes as apoptosis, mitochondrial diseases, and aging. During recent years it also ...
Karma Sonia - - 2011
Background: Background: The management of the older constituted a problematic that will be more attractive in the future because of the population's advanced age. Aim: To evaluate the management of the older more than 75 years that presented an arrest chest. Methods: Retrospective study during 12 months (from the first ...
Hartmann Nils - - 2011
Among vertebrates that can be kept in captivity the annual fish Nothobranchius furzeri possesses the shortest known lifespan. It also shows typical signs of ageing and is therefore an ideal model to assess the role of different physiological and environmental parameters on ageing and lifespan determination. Here we used Nothobranchius ...
Acuña-Castroviejo Darío - - 2012
We assessed whether melatonin administration would prevent the hyperoxidative status that occurs in lung mitochondria with age. Mitochondria from lungs of male and female senescent prone mice at 5 and 10 months of age were studied. Age-dependent mitochondrial oxidative stress was evaluated by measuring the levels of lipid peroxidation and ...
Ungvari Zoltan Z Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, - - 2011
There is strong evidence showing that aging is associated with vascular oxidative stress, which has been causally linked to the development of cardiovascular diseases. NF-E2-related factor-2 (Nrf2) is a transcription factor, which is activated by reactive oxygen species in the vasculature of young animals leading to the upregulation of various ...
Zhang Le L Pennington Biomedical Research Center/LSU System, Baton Rouge, LA 70808, - - 2011
As a part of aging there are known to be numerous alterations which occur in multiple tissues of the body, and the focus of this study was to determine the extent to which oxidative stress and hypoxia occur during adipose tissue aging. In our studies we demonstrate for the first ...
Lores-Arnaiz S - - 2011
Brain aging has been associated with mitochondrial dysfunction and changes in nitric oxide levels. The aim of this study was to evaluate the susceptibility of synaptic and non-synaptic mitochondria to aging-dependent dysfunction. State 3 respiratory rate and respiratory control were 43% and 33% decreased, respectively in brain cortex synaptosomes from ...
Masharawi Y - - 2011
Quantifying the human vertebral geometry is important for accurate medical procedures. We aimed to characterize the neural arch (NA) shape at T1-L5. All T1-L5 dry vertebrae (N = 4,080) of 240 individuals were measured and analyzed by age, gender, and ethnicity. A 3D digitizer was used to measure the dimensions ...
Valerio Alessandra - - 2011
Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms ...
Kotani Kazuhiko - - 2011
Aim:  Oxidative stress may be associated with the pathophysiology of knee osteoarthritis (OA), a health-care issue. The present study aimed to compare oxidative status levels of patients with and without knee OA, using the Reactive Oxygen Metabolites (d-ROMs, Diacron, Italy) test, which has proved to be clinically useful as an ...
Röcke Christina - - 2011
Objectives and Methods. Using 5 measurement bursts spanning 1 year, this study examined correspondences between retrospective end-of-year ratings and momentary ratings of positive affect (PA) and negative affect (NA) in 53 older adult participants from the Berlin Aging Study. RESULTS: Average momentary assessments were moderately positively correlated with retrospective ratings ...
Harrison Christopher - - 2011
From April 2006 to March 2010 in BEACH (Bettering the Evaluation and Care of Health), for females aged 14-17 years, contraception was managed at a rate of 8.8 per 100 encounters, second only to acute upper respiratory infections (10.1 per 100 encounters) as the most common problem managed for this ...
van Rijn Laurentius J - - 2011
Purpose:  This study aimed to investigate the prevalence of impairment of visual function amongst European drivers. Methods:  A total of 2422 drivers from five European countries underwent a battery of visual function tests, including tests for visual acuity (VA), visual field (VF), contrast sensitivity, straylight (glare sensitivity) and useful field ...
Sjöstrand Johan - - 2011
Purpose:  This study aimed to analyse the decline in visual acuity (VA) during normal ageing in two Scandinavian population samples of subjects aged ≥ 70 years and to study the age-specific decline in VA in eyes with early age-related maculopathy (ARM). Methods:  We carried out a cross-sectional analysis of data pertaining to ...
Mei Juan - - 2011
Aged refuse from waste landfills closed for eight years was examined and found to contain rich methanotrophs capable of biooxidation for methane. Specially, community structure and methane oxidation capability of methanotrophs in the aged refuse were studied. The amount of methanotrophs ranged 61.97 x 10(3)-632.91 x 10(3) cells/g (in dry ...
Park Seong-Hoon - - 2011
One fundamental observation in cancer etiology is that the rate of malignancies in any mammalian population increases exponentially as a function of age, suggesting a mechanistic link between the cellular processes governing longevity and carcinogenesis. In addition, it is well established that aberrations in mitochondrial metabolism, as measured by increased ...
Desler Claus - - 2011
Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression. Alterations of the mitochondrial genome accumulate both in aging tissue and tumors. This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related ...
Wang Jiajia - - 2011
To investigate associations between occupational exposure to cooking oil fumes (COFs) and potential oxidative and genotoxic effects in kitchen workers. Sixty-seven male kitchen workers and 43 male controls from Chinese restaurants in Guangzhou were recruited. For all the participants, the levels of 1-hydroxypyrene (1-OHP) and 8-hydroxy-2-deoxyguanosine (8-oxodG) in urine, binucleated ...
Chérif Saïda Fatma - - 2011
Potassium sodium silver tetra-niobium nona-oxide arsenate, K(0.12)Na(0.54)Ag(0.34)Nb(4)AsO(13), synthesized by solid-state reaction at 1123 K, adopts a three-dimensional framework delimiting tunnels running along [001] in which occupationally disordered sodium, silver, and potassium ions are located. Of the 11 atoms in the asymmetric unit (two Nb, one As, one Ag, one K, one ...
Goto Hajimu - - 2011
The purpose of our study is to investigate whether there is an age-related change in T1 rho values and to evaluate the effects of weight bearing on age-related increase in T1 rho values of normal cartilage. Thirty-two asymptomatic patients were examined using a 3.0T MRI to determine knee cartilage T1 ...
Suski Jan M - - 2011
Reactive oxygen species (ROS) are wieldy accepted as one of the main factors of the aging process. These highly reactive compounds modify nucleic acids, proteins and lipids and affect the functionality of mitochondria in the first case and ultimately of the cell. Any agent or genetic modification that affects ROS ...
Zeleke Zeyede K - - 2011
There are only a few follow-up studies of respiratory function among cement workers. The main aims of this study were to measure total dust exposure, to examine chronic respiratory symptoms and changes in lung function among cement factory workers and controls that were followed for one year. The study was ...
Sakwari Gloria - - 2011
Coffee processing causes organic dust exposure which may lead to development of respiratory symptoms. Previous studies have mainly focused on workers involved in roasting coffee in importing countries. This study was carried out to determine total dust exposure and respiratory health of workers in Tanzanian primary coffee-processing factories. A cross ...
Groleau Jessika - - 2011
Aging is associated with increased oxidative stress levels and impaired neovascularization following ischemia. CuZnSOD has an important role to limit oxidative stress in the vasculature. Here we investigated the role of CuZnSOD for the modulation of ischemia-induced neovascularisation during aging. Hindlimb ischemia was surgically induced in young (2- month-old) or ...
Dos Santos Daniela Micheline - - 2011
Purpose: The aim of this study was to evaluate the influence of two pigments (ceramic powder and oil paint) and one opacifier (barium sulfate) on the color stability of MDX4-4210 facial silicone submitted to accelerated aging. Materials and Methods: Sixty specimens of silicone were fabricated and divided into six groups--colorless ...
Harris Maureen E ME Department of Ophthalmology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, - - 2011
The purpose of this study was to determine whether recovery of scotopic sensitivity occurs in human ROP, as it does in the rat models of ROP. Following a cross-sectional design, scotopic electroretinographic (ERG) responses to full-field stimuli were recorded from 85 subjects with a history of preterm birth. In 39 ...
Guerreiro Maria J S - - 2010
Selective attention requires the ability to focus on relevant information and to ignore irrelevant information. The ability to inhibit irrelevant information has been proposed to be the main source of age-related cognitive change (e.g., Hasher & Zacks, 1988). Although age-related distraction by irrelevant information has been extensively demonstrated in the ...
Ben-David Boaz M - - 2010
An increase in Stroop effects with age can be interpreted as reflecting age-related reductions in selective attention, cognitive slowing, or color-vision. In the present study, 88 younger adults performed a Stroop test with two color-sets, saturated and desaturated, to simulate an age-related decrease in color perception. This color manipulation with ...
Owsley Cynthia C Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0009, USA. - - 2011
Given the increasing size of the older adult population in many countries, there is a pressing need to identify the nature of aging-related vision impairments, their underlying mechanisms, and how they impact older adults' performance of everyday visual tasks. The results of this research can then be used to develop ...
François M - - 2011
The ability to control locomotion through the environment and to intercept, or avoid objects is fundamental to the survival of all locomotor species. The extent to which this control relies upon optic flow, visual direction cues or non-visual sensory inputs has long been debated. Here we look at the use ...
Shevlin Mark - - 2011
Numerous studies of both clinical and large-scale population based samples have demonstrated that adverse childhood events are risk factors for subsequent psychosis. This study assessed the relationships between adverse childhood events and auditory and visual hallucinatory experiences. The study analysed data from the National Comorbidity Survey Replication conducted in the ...
Tan Thean Yen - - 2010
This study investigated the effect of different Mueller-Hinton agars and media age on tigecycline MICs, obtained by Etest. Variations in MIC values on different Mueller-Hinton were noted, which may result in changes in categoric susceptibility. The use of stored Mueller-Hinton media had minimal effect on MIC values.
Illing Sara - - 2010
To examine age-related changes in postural stability and sensory system functioning in men aged 30-80 years. Observational, cross-sectional study. One hundred six healthy men aged 30-80 years participated. Personal characteristics were recorded and outcome measures included: velocity of sway during bilateral stance on a firm and foam surface (eyes open ...
Kolesnikov Alexander V - - 2010
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically, photoreceptors. According to one hypothesis, the age-related deterioration in rod function is due to ...
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