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Li Yufei - - 2013
Connective tissue aging and diabetes related comorbidity are associated with compromised tissue function, increased susceptibility to injury, and reduced healing capacity. This has been partly attributed to collagen cross-linking by advanced glycation end-products (AGEs) that accumulate with both age and disease. While such cross-links are believed to alter the physical ...
Pezic Angela - - 2013
Our aim was to examine the association between ethnicity, phenotype, sun behaviour and other characteristics, and constitutive and relative facultative skin pigmentation. 191 participants were recruited, with a mean age of 7.6 years (SD 3.4), during 2009-2011 from Maternal and Child Health Centres and schools in Melbourne, Australia. Parental questionnaire ...
Yu Tung-Yang - - 2013
ABSTRACT: BACKGROUND: Most tendon pathology is associated with degeneration, which is thought to involve cyclic loading and cumulative age-related changes in tissue architecture. However, the association between aging and degeneration of the extracellular matrix (ECM) in tendons has not been investigated extensively. METHODS: We examined tenocytes from Achilles tendons taken ...
Simpson Jodie L - - 2013
Chronic obstructive pulmonary disease (COPD) is a common and serious respiratory disease, particularly in older individuals, characterised by fixed airway obstruction and persistent airway neutrophilia. The mechanisms that lead to these features are not well established. We investigated the contribution of age, prior smoking, and fixed airflow obstruction on sputum ...
Rybczynski Natalia - - 2013
The mid-Pliocene was a global warm period, preceding the onset of Quaternary glaciations. Here we use cosmogenic nuclide dating to show that a fossiliferous terrestrial deposit that includes subfossil trees and the northern-most evidence of Pliocene ice wedge casts in Canada's High Arctic (Ellesmere Island, Nunavut) was deposited during the ...
Pradeep Avani R - - 2013
A defined role for reactive oxygen species (ROS) in the tissue destruction that characterizes periodontitis has been described. Protein carbonyl (PC) is the most widely used biomarker for oxidative damage to proteins, and reflects cellular damage induced by multiple forms of ROS. The purpose of this study is to determine ...
Itoh Shinsuke - - 2013
To examine the role of connective tissue growth factor CCN2/CTGF (CCN2) in the maintenance of the articular cartilaginous phenotype, we analyzed knee joints from aging transgenic mice (TG) overexpressing CCN2 driven by the Col2a1 promoter. Knee joints from 3-, 14-, 40-, and 60-day-old and 5-, 12-, 18-, 21-, and 24-month-old ...
Yeşil Hilal - - 2013
This cross-sectional study was conducted to determine the prevalence of symptomatic knee, hand and hip osteoarthritis among men and women at or over 40 years of age, living in the Bayraklı Adalet district of İzmir. The study included a sample size of 522 people calculated using the Epi Info™ software. ...
Tsutaya Takumi - - 2013
Nitrogen isotope analysis of bone collagen has been used to reconstruct the breastfeeding practices of archaeological human populations. However, weaning ages have been estimated subjectively because of a lack of both information on subadult bone collagen turnover rates and appropriate analytical models. Temporal changes in human subadult bone collagen turnover ...
Jenabian Niloofar - - 2013
Background: Chronic renal failure patients undergoing hemodialysis are susceptible to periodontal diseases due to systemic complications of the disease and using different drugs. The present study investigated the periodontal status of patient's who underwent hemodialysis, in Babol, northern Iran. Methods: One-hundred-fifteen hemodialysis patients (63 males, 52 females) with the mean ...
Jentzsch Thorsten T Division of Trauma Surgery, Department of Surgery, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, - - 2013
We retrospectively analyzed CT scans of 620 individuals, who presented to our traumatology department between 2008 and 2010. Facet joint (FJ) arthritis was present in 308 (49.7%) individuals with a mean grade of 1. It was seen in 27% of individuals ≤40 years and in 75% of individuals ≥41 years ...
den Dekker Martijn A M MA Center for Medical Imaging - North East Netherlands, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands ; Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The - - 2013
Advanced glycation endproducts (AGEs) may be involved in the development of atherosclerosis, beyond diabetes and renal disease. Skin autofluorescence (AF) is a non-invasive marker for AGEs. We examined whether skin AF is increased in (subclinical) atherosclerosis and associated with the degree of atherosclerosis independent of diabetes and renal function. A ...
Bonta Marinela M Department of Psycho-Neuroscience and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Romania; - - 2013
Structural and functional alterations, as well as changes occurring in the aspect of the skin during the ageing process, are due to some complex mechanisms, determined by intrinsic and extrinsic factors, which act synergistically. This study aims to analyze the histological changes of collagen and elastic fibers and of skin ...
Zheng Qian Q Global Research and Development, Avon Products Inc., Suffern, New York, - - 2013
During aging, the reduction of elastic and collagen fibers in dermis can lead to skin atrophy, fragility, and aged appearance, such as increased facial wrinkling and sagging. Microfibril-associated glycoprotein-1 (MAGP-1) is an extracellular matrix protein critical for elastic fiber assembly. It integrates and stabilizes the microfibril and elastin matrix network ...
Haftek Marek M Université Lyon 1, Laboratoire de Recherche Dermatologique, Faculté de Médecine et de Pharmacie, Lyon, - - 2013
Epidemiologic information regarding the prevalence of "fragile skin" in different adult populations is currently limited. The objective of the current survey was to assess the occurrence of perceived "fragile skin" across different skin types in the general adult population. Individuals aged 15-65 years from five representative geographic regions (France, Spain, ...
Torricelli P - - 2012
Little is known about tendons and tenocyte biological behaviour during aging and, especially, oestrogen deficiency. The aim of this study was to evaluate in vitro the proliferation and metabolism of tenocytes isolated from the Achilles tendons of ovariectomised (OVX), middle-aged (OLD) and young (YOUNG) rats. An in vitro model of ...
Gulihar Abhinav - - 2012
PURPOSE: The goal of this study was to examine the effect of different irrigation fluids on human articular cartilage. METHODS: Femoral heads were obtained from 9 patients with fractured neck of femur (mean age, 89 years; 7 female) and tibial plateaus from 2 female patients at the time of total ...
Tirgan Michael H - - 2012
Keloid disorder (KD) is a fibroproliferative ailment of the cutaneous connective tissue secondary to dysregulation in various skin repair and healing processes. This disorder is characterized by excess collagen and/or glycoprotein depositions in the dermis. Age of onset of KD is not well documented. Based on clinical observations, various authors ...
Ong Kwok Leung - - 2012
OBJECTIVE: Arthritis is associated with cardiovascular diseases (CVDs). However, there are limited epidemiologic studies on arthritis in a national survey study. We therefore investigated the prevalence of self-reported arthritis and its association with CVDs. METHODS: Data from 15,888 subjects aged 40 years or older in the United States National Health ...
Tadakamadla Jyothi - - 2012
To assess the effect of smoking on lip and gingival pigmentation and also to assess the relationship of pigmentation with periodontal parameters. 109 smokers and an equal number of control subjects who were nonsmokers in the age range of 35 - 44 years comprised the study sample. All the participants ...
Sacitharan Pradeep K PK Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, United - - 2012
Arthritic disease is one of the most common age-related pathologies worldwide. The erosion of cartilaginous tissues from articular surfaces within the joint and the failure to efficiently repair and regenerate this region with age lead to debilitating joint destruction, severe pain, and a crippling loss of function. In addition to ...
Javed Fawad - - 2012
Background: It is known that gutka-chewing jeopardizes periodontal health; however, severity of periodontal inflammation in gutka-chewers with and without prediabetes remains unknown. The aim was to investigate the association of periodontal inflammatory conditions with gutka-chewing and pre-diabetes. Methods: In this cross-sectional study, the effect of gutka use on periodontal health ...
van Doorn Nienke L - - 2012
Non-enzymatic deamidation accumulates in aging tissues in vivo and has been proposed to be potentially useful as a molecular clock. The process continues post mortem, and here we explore the increase in levels of deamidation in archaeological collagen, as measured during Zooarchaeology by Mass Spectrometry (ZooMS) analysis. With the high ...
Liu Guo-Min - - 2012
The conventional lumbar separation was performed by removing soft tissue, subsidiary structures and leaving only the vertebral body. The vertebral body was cut into two halves along the median sagittal plane, keeping the upper and lower end plates of each half, which were subsequently used for biomechanical, morphological and density ...
Singh Amrinder - - 2012
Chronic periodontitis is seen in majority of population and is responsible for the high tooth morbidity as well as mortality. One thousand and twenty-six subjects were selected by multistage stratified randomized sampling technique. They were examined in free dental camps organized in preselected rural areas by using community periodontal index ...
Baroni Eloina do Rocio Valenga Edo - - 2012
Evaluate the influence of aging on the quality of the skin of white women, analyzing the dermal collagen. Pre-auricular flaps were collected for histological and morphometric analysis of 218 white women who underwent spontaneous facial aesthetic plastic surgery. Picrosirius ultrared stain was used for analysis and quantification of collagen in ...
Sataranatarajan Kavithalakshmi - - 2012
We explored molecular events associated with aging-induced matrix changes in the kidney. C57BL6 mice were studied in youth, middle age and old age. Albuminuria and serum cystatin C level (an index of glomerular filtration) increased with aging. Renal hypertrophy was evident in middle-aged and old mice and was associated with ...
Canavarro Cristiane - - 2012
SUMMARY This randomized split-mouth study aimed to examine the levels of matrix metalloproteinases (MMPs) -1, -2, -3, -7, -8, -12, and -13 in the gingival crevicular fluid (GCF) at different time points during orthodontic tooth movement. A total of 16 healthy orthodontic subjects (7 females, 9 males; mean age, 17.7 ...
Laxafoss Erling - - 2012
INTRODUCTION: The aim of the present study was to describe the changes in the axis of the knee joint in both radiologically osteoarthritic and non-osteoarthritic knees, on the basis of angles measurable in standardized clinical short knee radiographs, in a cross sectional study of an epidemiological cohort. DESIGN: From the ...
Farnsworth Nikki L - - 2012
Age is a risk factor in developing osteoarthritis, but the link is not well understood. It is thought that age predisposes the tissue to osteoarthritis when other risk factors are involved, e.g. abnormal biomechanics. Therefore, this study aimed to test the hypothesis that chondrocyte response to injurious loading is dependent ...
Inci Mehmet - - 2012
The objective of this study was to determine femoral cartilage thickness (FCT) in patients with Klinefelter syndrome (KS), which is the most common sex chromosome disorder in men with varying degrees of androgen deficiency. This cross-sectional controlled study was conducted in a tertiary care center. Participants were 33 male patients ...
Rakhra K S - - 2012
Advanced MRI cartilage imaging such as T(1)-rho (T1ρ) for the diagnosis of early cartilage degradation prior to morpholgic radiological changes may provide prognostic information in the management of joint disease. This study aimed first to determine the normal T1ρ profile of cartilage within the hip, and secondly to identify any ...
Ferraz Mara Lúcia da Fonseca - - 2012
To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and ...
Tobón-Arroyave Sergio I - - 2012
AIM: To determine the variations in salivary concentrations of sRANKL, osteoprotegerin (OPG) and its ratio, regarding the periodontal status. MATERIALS AND METHODS: Ninety-seven chronic periodontitis (CP) subjects and 43 healthy controls were selected. Periodontal status was assessed based on full-mouth clinical periodontal measurements. sRANKL and OPG salivary levels were analysed ...
Türkmen Süha - - 2012
AIM: To define radiological physiological changes in the larynx by establishing an age-related scale. MATERIALS AND METHODS: The present retrospective study used radiological records of patients that had undergone lateral cervical imaging. Three hundred patients were included. Thyroid cartilage was divided into anatomical regions. The hyoid bone was evaluated as ...
Cha Jang Gyu - - 2012
To compare changes in T2 relaxation on magnetic resonance (MR) images of knee articular cartilage in younger and older amateur athletes before and after running. By using a 3.0-T MR imager, quantitative T2 maps of weight-bearing femoral and tibial articular cartilages in 10 younger and 10 older amateur athletes were ...
Andersen Paal Skytt - - 2012
Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus ...
Aït-Belkacem Dora - - 2012
ABSTRACT. Polarization resolved second harmonic generation (PSHG) is developed to study, at the microscopic scale, the impact of aging on the structure of type I collagen fibrils in two-dimensional coatings. A ribose-glycated collagen is also used to mimic tissue glycation usually described as an indicator of aging. PSHG images are ...
Chong Vui Heng - - 2012
To assess the gender preferences, specifically the gender of the nursing staff (endoscopy assistants) and the impact on acceptance for screening colonoscopy (SC). Patients or relatives attending the clinics or health care workers working in a tertiary center were invited to participate in this questionnaire study. The questionnaire enquired on ...
Abraham Anasooya - - 2012
BACKGROUND: Randomized trials demonstrating the benefits of chemotherapy in patients with American Joint Committee on Cancer stage III colon cancer underrepresent persons aged ≥ 75 years. The generalizability of these studies to a growing elderly population remains unknown. METHODS: Using the California Cancer Registry for 1994 through 2008, the authors ...
O'Toole P W - - 2012
Clin Microbiol Infect 2012; 18 (Suppl. 4): 44-46 ABSTRACT: The human intestinal microbiota comprises a complex community whose composition has been resolved in fine detail by recent culture-independent methodologies. The adult intestinal microbiota is stable within individuals, and individual specific when examined at high resolution. Infants and older persons, however, ...
Kühne Ulrich - - 2012
Following the trend in facial cosmetic procedures, patients are now increasingly requesting hand rejuvenation treatments. Intrinsic ageing of the hands is characterized by loss of dermal elasticity and atrophy of the subcutaneous tissue. Thus, veins, tendons and bony structures become apparent. Among the available procedures, intrinsic ageing of the hands ...
Nagy-Szakal Dorottya D Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, - - 2012
Epidemiologic data suggest that early nutritional exposures may inflict persistent changes in the developing mammalian "super-organism" (i.e., the host and its residing microbiota). Such persistent modifications could predispose young adults to inflammatory bowel diseases (IBD). We recently observed that the dietary supplementation of four micronutrients to dams augmented colitis susceptibility ...
Foocharoen Chingching C Division of Allergy-Immunology-Rheumatology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand. - - 2012
Skin thickness progression in scleroderma (SSc) varies in daily clinical practice observation. To define the pattern of skin thickness among Thai sufferers of SSc and to ascertain the clinical correlation with each skin pattern. A 3-year follow-up cohort was performed on patients over 15 years of age in Khon Kaen, ...
Gondolesi G - - 2012
Normal small bowel length (SBL) has been reported within a wide range, but never studied in a cohort of either pediatric or adult deceased donors. Between 5/2006 and 2/2011, SBL was measured in all grafts procured for intestinal transplantation at a single center and used for either isolated intestinal transplant ...
Pereira A Dias - - 2012
BACKGROUND: The definition of Barrett's oesophagus lacks consensus, particularly the requirement of intestinal metaplasia for diagnosis. Scarce information exists on the prevalence and natural history of columnar-lined oesophagus without intestinal metaplasia. AIM: To evaluate the demographics and natural history of columnar-lined oesophagus without intestinal metaplasia ≥2 cm in length. METHODS: Patients ...
Kyrklund Kristiina - - 2012
: Limited information exists on what constitutes normal bowel function in children and adolescents. This information is essential for determining outcomes of surgery for anorectal malformations and other colonic disorders. : The aim of this study was to define bowel function and fecal continence in a large sample of individuals ...
Zubaidi Ahmad M - - 2012
To study bowel patterns (function/habits) and its associated variables in an adult Saudi population. In a cross sectional study, a 21-item questionnaire on bowel function (habits and frequency) was distributed to 10,000 high school students from all 5 regions of Riyadh City, Saudi Arabia, between February and April 2011. The ...
Scott Frank I - - 2012
Postoperative adhesions are common after surgery and can cause small-bowel obstruction (SBO) and require adhesiolysis. The impact that laparoscopy and other surgical advances have had on rates of SBO and adhesiolysis remains controversial. This study examines trends in discharges from US hospitals for SBO and adhesiolysis from 1988 to 2007. ...
Rao S S C - - 2012
There is scarce information regarding assessment of constipation in older subjects. We examined regional and whole-gut transit time (WGTT) with wireless motility capsule (WMC) and compared this with radioopaque markers (ROM) transit. 39 constipated and 11 healthy older subjects (≥65 years) ingested a ROM capsule and WMC, wore a data ...
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