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Labat-Robert J J Hotel-Dieu Hospital, Paris V University, Paris, - - 2014
In this chapter, we describe in detail the age-dependent modifications of connective tissues, separately for their cellular and extracellular compartments. Cell aging was studied by the in vitro method established by Hayflick as well as by ex vivo explant cultures, and results with both methods are discussed. Follows then the ...
van der Kraan Peter M PM Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The - - 2014
Age is the most important risk factor for primary osteoarthritis (OA). Members of the TGF-β superfamily play a crucial role in chondrocyte differentiation and maintenance of healthy articular cartilage. We have investigated whether age-related changes in TGF-β superfamily signaling components play a role in the relationship between OA-related cartilage degradation ...
Hanada Michiko M Faculty of Animal Health Technology, Department of Animal Health Technology, Yamazaki Gakuen University, Tokyo 150-0046, - - 2014
Uteri from 50 necropsied nonpregnant Japanese Thoroughbred brood mares (1-30 years of age) were investigated to clarify the histopathological characteristics of endometrosis in Japanese Thoroughbred mares and the distribution pattern of endometrosis lesions in the uterus as a whole. Endometrosis was observed in all animals over 6 years of age ...
Herrero Carlos Fernando P S CF Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, - - 2014
Endplate separations are defined as the presence of a space between the hyaline cartilage and the cortical bone of the adjacent vertebral body. This study evaluates endplate separations from the vertebral body and intervertebral discs and verifies if endplate separation is related to age and the spinal level. Groups were ...
Wan Chao C State Key Laboratory of Tribology, Tsinghua University, Beijing, - - 2014
The mechanical properties of ligaments are key contributors to the stability and function of musculoskeletal joints. Ligaments are generally composed of ground substance, collagen (mainly type I and III collagen), and minimal elastin fibers. However, no consensus has been reached about whether the distribution of different types of collagen correlates ...
Bradke Brian S BS Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, United States of - - 2014
Nonenzymatic glycation (NEG) describes a series of post-translational modifications in the collagenous matrices of human tissues. These modifications, known as advanced glycation end-products (AGEs), result in an altered collagen crosslink profile which impacts the mechanical behavior of their constituent tissues. Bone, which has an organic phase consisting primarily of type ...
Hinman Rana S RS Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, University of Melbourne, Victoria, - - 2013
Objective: To document the prevalence of radiographic OA in the medial and lateral patellofemoral joint (PFJ) compartments relative to prevalence of tibiofemoral joint (TFJ) OA in middle-aged and older adults with chronic patellofemoral knee pain. Methods: A convenience sample of 224 people who volunteered for a clinical trial underwent weight-bearing ...
Nowotny Kerstin K Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University, Jena, - - 2013
Skin aging is a multifactorial process leading to structural and physiological changes.Protein modifications are known to play here an important role. Since collagen is the most abundant protein in the extracellular matrix of the skin and due to its slow turnover rates it is a frequent target of modifications by ...
Sunwoo Woong Sang - - 2013
IMPORTANCE Rib cartilage from the sixth, seventh, and eighth ribs offers a long cartilaginous curvature, making the material reliable for grafting. Calcification of cartilage causes unexpected absorption, difficult manipulation, and donor site morbidity. Most studies of calcification were performed in Western countries. OBJECTIVE To investigate the incidence, degree, and pattern ...
Fields Aaron J AJ Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, 513 Parnassus Avenue, S-1157, San Francisco, California, - - 2014
Endplate cartilage integrity is critical to spine health and is presumably impaired by deterioration in biochemical composition. Yet, quantitative relationships between endplate biochemical composition and biomechanical properties are unavailable. Using endplate cartilage harvested from human lumbar spines (six donors, ages 51-67 years) we showed that endplate biochemical composition has a ...
Kim Tae-Hwan TH *Spine Center, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea; and †Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, - - 2013
Cross-sectional study of preselected cohort of patients with neck pain. To determine the association between joint laxity and lumbar disc degeneration in young adults. Joint laxity is known to be closely related with orthopedic injuries and disease; however, studies about the relationship between spinal disorder and joint laxity are lacking. ...
Lenskjold A - - 2013
Achilles tendinopathy is a highly prevalent sports injury. Animal studies show a growth response in tendons in response to loading in the immature phase but not after puberty maturation. The aim of this investigation was to examine the structural and material properties in long distance runners who were either physically ...
Kolozsvári Bence Lajos - - 2013
Purpose: To study the association between different types of mediators in the tear fluid and topographic indices characterizing the severity of keratoconus (KC). Methods: In this study, nonstimulated tear fluid samples were collected from 14 eyes of 11 patients with KC. The following indices were measured by corneal topography: maximum ...
Matzenauer Christian - - 2013
Age estimation based on aspartic acid racemization (AAR) has been applied successfully to various tissues. For routine uses, AAR is analyzed in dentine. For cases in which teeth are unavailable, analyzing AAR in purified elastin has been shown to be an alternative method. The suitability of elastic cartilage from the ...
Moghimi Nasrin - - 2013
This study aims to conduct an urban Community Oriented Program for Control Of Rheumatic Diseases (COPCORD) study in Sanandaj (Kurdistan, Iran). Sanandaj with a population of 311,446 (2006 census), Caucasian of Kurdish subgroup, was selected as the field. Sanandaj was divided into 100 clusters and subjects were randomly selected from ...
Miura Jiro J Division for Interdisciplinary Dentistry, Osaka University Dental Hospital, Japan. Electronic address: - - 2014
Cross-linking of collagen by Advanced Glycation End-products (AGEs) occurs by non-enzymatic glycation (Maillard reaction). The purpose of this study was to examine whether AGEs are formed in human dentinal collagen, and to consider any possible influence of AGEs on dentinal physiology. Mechanical characteristics, fluorescence spectra and immunohistochemical analyses of demineralized ...
Gray Kristen E - - 2013
Telomere length is a marker of cellular aging that varies with the individual, is inherited, and is highly correlated across somatic cell types within persons. Interindividual variability of telomere length may partly explain differences in reproductive aging rates. We examined whether leukocyte telomere length was associated with menopausal age. We ...
Vos Lukas M - - 2013
Most of the current understanding of articular cartilage maintenance and degradation is derived from large load-bearing synovial joints, in particular the knee joint. The aim of this study was to identify valuable degradation markers for cartilage degradation in the temporomandibular joint (TMJ) by comparing the relative concentrations of carboxyterminal telopeptides ...
Staufenbiel Ingmar - - 2013
Marfan syndrome (MFS) is a disorder of the connective tissues. Alterations of the elastic fibers may manifest in different tissues especially in the skeletal, cardiovascular and ocular system. Oral manifestations like orthodontic or skeletal anomalies and fragility of the temporomandibular joint have been well described by various authors. However, no ...
Suvan J J Unit of Periodontology, UCL, Eastman Dental Institute, London, - - 2014
Body mass index (BMI) and obesity are associated with the prevalence, extent, and severity of periodontitis. This study investigated the predictive role of overweight/obesity on clinical response following non-surgical periodontal therapy in patients with severe periodontitis. Two hundred sixty adults received an intensive course of non-surgical periodontal therapy. Periodontal status ...
Leaker Sarah Helen - - 2013
Old age, pressure ulcers and malnutrition may co-exist. Wounds in older people may already be slow to heal as a result of compromised skin integrity, which occurs as part of the normal ageing process. Malnutrition is also more common in older people, and evidence has shown that inadequate nutrition may ...
Chai Toby C TC University of Maryland, Baltimore, Maryland. Electronic address: - - 2014
Urinary biomarkers were measured in women at baseline and 1 year after surgery for stress urinary incontinence, and associations with clinicodemographic covariates and outcomes were analyzed. Preoperative and postoperative urine specimens from 150 women were assayed for inflammatory biomarkers (tumor necrosis factor-α, interferon-γ, interleukin-1β, interleukin-6, interleukin-10, interleukin-12p70, interleukin-17 and nerve ...
Paim Layde R - - 2013
Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role ...
Chang Jun - - 2013
The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage. Surprisingly, we found that ...
Gentile Nicole M - - 2013
The increasing incidence of microscopic colitis has been partly attributed to detection bias. We aimed to ascertain recent incidence trends and the overall prevalence of microscopic colitis in a population-based study. Using data from the Rochester Epidemiology Project, we identified residents of Olmsted County, Minnesota who were diagnosed with collagenous ...
Marshall Michelle - - 2013
To determine whether erosive osteoarthritis shares the same pattern of joint involvement and risk profile as increasing grades of non-erosive hand osteoarthritis. Participants were from two population-based cohorts, aged ≥50 years, reporting hand symptoms in the previous month. Interphalangeal joints were assessed for erosive osteoarthritis (Verbruggen-Veys erosive or remodelled phase) ...
Jiang Rui - - 2013
With aging, the human fracture risk gradually increase. This is mainly due to the corresponding changes of the biomechanical parameters of human bone presents with aging. We measured the microstructural parameters of lumbar bone from women in several age groups by micro-computed tomography and scanning electron microscopy. We observed changes ...
Swami Viren - - 2013
This study examined skin tone dissatisfaction, measured using a skin tone chart, among a multiethnic sample of British adults. A total of 648 British White individuals, 292 British South Asians, and 260 British African Caribbean participants completed a visual task in which they were asked to indicate their actual and ...
Pawlaczyk Mariola M Department of Geriatrics and Gerontology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Mariola Pawlaczyk MD, - - 2013
The skin fulfills one of its most important functions, that is protection from mechanical injuries, due to the mechanism of reversible deformation of the structure. Human skin is a complex living material but in biomechanical tests it reveals its homogeneous nature. Biomechanical skin parameters change with time. Results of thickness ...
Dev Yash Paul YP Professor and Head, Department of Periodontics, Swami Devi Dayal Hospital and Dental College , India - - 2013
To determine whether there is a relationship between periodontal disease and rheumatoid arthritis. A total of 1520 (852 - periodontal group; 668 - general group) individuals of 30-70 years age group and residents of Baddi industrial estate in Himachal Pradesh, India, were assessed for the prevalence of rheumatoid arthritis and ...
Liutkeviciene Rasa - - 2013
Abstract Background: Matrix metalloproteinases (MMP) are responsible for the degradation of extracellular matrix components and play an important role in the physiological and pathological remodeling of tissues. Purpose: To assess the impact of MMP-2 Rs2285053 (C -> T), MMP-3 Rs3025039 (5A -> 6A), and MMP-9 Rs3918242 (C -> T) single nucleotide polymorphism on the development of ...
Gautieri Alfonso - - 2013
Ageing and diabetes share a common deleterious phenomenon, the formation of Advanced Glycation Endproducts (AGEs), which accumulate predominantly in collagen due to its low turnover. Though the general picture of glycation has been identified, the detailed knowledge of which collagen amino acids are involved in AGEs is still missing. In ...
Wilson Samantha L - - 2013
During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic and macroscopic properties of different-aged collagens from newborn to 2-yr-old rats, to examine the effect of aging on fibrillogenesis, ...
Farwick M - - 2013
Background: Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production. Here, their effects on cutaneous aging by means of objective instrumental measurements were elucidated. Methods: Reconstituted human epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of various ...
Radlović Vladimir V University Children's Hospital, Belgrade, Serbia. - - 2013
Pseudoachondroplasia (PSACH) is an autosomal dominant osteochondrodysplasia due to mutations in the gene encoding cartilage oligomeric matrix protein. It is characterized by rhizomelic dwarfism, limb and vertebral deformity, joint laxity and early onset osteoarthrosis. We present the girl with the early expressed and severe PSACH born to clinically and radiographically ...
Wilcox James R JR Healogics, Jacksonville, - - 2013
Chronic wounds usually get trapped in the inflammatory stage of wound healing; however, aggressive debridement transforms chronic wounds to acute wounds and therefore complete healing. To investigate healing outcomes and debridement frequency in a large wound data set. Retrospective cohort study. Data collected from 525 wound care centers from June ...
Krieger Elena - - 2013
Recently, research has focused intensely on age-related tissue changes, not only in the field of dermatology but also in dental sciences. Although many new insights into age-related morphological, ultrastructural and biochemical changes in the periodontal ligament tissue have been gained, the basic question of whether there is a quantitative change ...
Vafaie Faran - - 2013
Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r) ) that yields collagenase-resistant type I collagen. Compared to wild-type littermates, Col1a1(r/r) mice ...
Wickbom Anna - - 2013
The incidence of microscopic colitis (MC) has increased in several centers, but long-term epidemiologic data are missing. We report an epidemiologic study of collagenous colitis (CC) and lymphocytic colitis (LC) during 1999-2008, as a follow-up of our previous studies 1984-1998. Population-based study of residents of the catchment area of the ...
Li Yong - - 2013
Proteoglycans, a family of glycosaminoglycan (GAG) conjugated proteins, are important constituents of human skin connective tissue (dermis) and are essential for maintaining mechanical strength of the skin. Age-related alterations of dermal proteoglycans have not been fully elucidated. We quantified transcripts of 20 known interstitial proteoglycans in human skin and found ...
Vos Lukas M - - 2013
There is a growing interest in markers for cartilage degradation in synovial joints because of their potential diagnostic and prognostic value. Therefore, the aim of this study was to identify valuable degradation markers for temporomandibular joint (TMJ) osteoarthritis (OA) by comparing the relative concentrations of carboxyterminal telopeptides type I and ...
Hashimoto Ichiro - - 2013
Coccygeal pad is a nodular lesion in the sacrococcygeal area, typically involving a proliferation of collagen bundles. The etiology and optimal treatment remain unclear. We investigated the etiology using a systematic review of the available published work, two cases that we examined and treated, and measurements of body pressure in ...
Qin Zhaoping - - 2013
Chronic exposure of human skin to solar ultraviolet (UV) irradiation causes premature skin aging, which is characterized by reduced type I collagen production and increased fragmentation of the dermal collagenous extracellular matrix. This imbalance of collagen homeostasis is mediated, in part, by elevated expression of the matricellular protein cysteine-rich protein ...
Harbo M - - 2013
Ultra-short telomeres caused by stress-induced telomere shortening are suggested to induce chondrocyte senescence in human osteoarthritic knees. Here we have further investigated the role of ultra-short telomeres in the development of osteoarthritis (OA) and in aging of articular cartilage in human hips. Cartilage was obtained from four different distances of ...
Calleja-Agius Jean - - 2013
Collagen atrophy is a major factor in skin ageing. A strong correlation exists between skin collagen loss and oestrogen deficiency caused by the menopause. Skin ageing is associated with a progressive increase in extensibility and a reduction in elasticity. With increasing age, the skin also becomes more fragile and susceptible ...
Lin W - - 2013
The purpose of this study was to analyze the longitudinal association between physical activity levels and early degenerative cartilage changes in the knee, measured using T2 relaxation times over a period of 4 years in individuals without clinical or radiographic evidence of OA. Cartilage T2 was measured at baseline and ...
Grieve Rob - - 2013
To determine the prevalence of latent myofascial trigger points (MTrPs), specific diagnostic criteria and the association between gender and MTrP prevalence in the triceps surae and upper trapezius. Cross-sectional study. University, Faculty of Health and Life Sciences. Two hundred and twenty healthy volunteers (132 females and 88 males; mean age ...
Peeran Syed Wali - - 2013
The occurrence of periodontal diseases in humans has been a global problem. Certain risk factors affect the initiation, progression, and severity of periodontitis. The present study has been designed to assess the periodontal status in relation to risk factors such as age, gender, oral hygiene practices, and smoking among the ...
Goyal N N Department of Anatomy, Christian Medical College, Ludhiana, - - 2013
Background Osteoarthritis (OA) is a common problem in elderly, but it is not an inevitable feature of ageing. About 80-90% of individuals of both sexes have radiographic evidence of OA by the time they reach an age of 65. But not all of them have the symptoms like pain and ...
Bhardwaj Vinay Kumar VK Department of Public Health Dentistry, H.P. Government Dental College and Hospital, Shimla, Himachal Pradesh, - - 2013
The literature shows that an increased body mass index (BMI) may be a potential risk factor for periodontitis. Association between BMI and periodontitis has been ascribed to unhealthy dietary patterns with insufficient micronutrients and excess sugar and fat content. The present study intended to assess the relation between BMI and ...
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