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Komosinska-Vassev Katarzyna K Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, Poland. Electronic address: - - 2014
The influence of age and gender factor on the urinary excretion of total glycosaminoglycans (uGAGs) and their particular types: chondroitin/dermatan sulfates (CS/DS), heparan sulfates (HS) and hyaluronan (HA) was analyzed in healthy pediatric and adolescent population. Urine samples were collected from 95 healthy children. Sulfated GAGs excreted in urine were ...
Shimada Tsutomu T Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, 1600 Rockland Rd., Wilmington, DE, 19899-0269, - - 2014
Chondroitin 6-sulfate (C6S), a glycosaminoglycan (GAG), is distributed mainly in the growth plates, aorta, and cornea; however, the physiological function of C6S is not fully understood. One of the limitations is that no rapid, accurate quantitative method to measure C6S has been established. Mucopolysaccharidosis IVA and VII (MPS IVA and ...
Wu Jun J Department of laboratory medicine, Beijing Jishuitan Hospital, Beijing 100035, - - 2014
Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters: lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation ...
Wehner Gabriele G Department of Internal Medicine (G.W., H.U.S), and Institute of Human Genetics (G.W.), University of Bonn, Bonn, - - 2014
Background: The present study investigated the metabolism of estrone sulfate into bioactive estrogens in the human hair root, including the effects of hair growth phase, anatomical site, gender and age. Methods: Healthy male (n=18) and female (n=20) subjects were investigated. Growing (anagen) and resting (telogen) hair roots were collected from ...
Chu Biwu - - 2014
Smog chamber experiments were conducted to investigate the hygroscopicity of particles generated from photooxidation of alpha-pinene/NO(x) with different sulfate seed aerosols or oxidation conditions. Hygroscopicity of particles was measured by a tandem differential mobility analyzer (TDMA) in terms of hygroscopic growth factor (Gf), with a relative humidity of 85%. With ...
Calamia Valentina V 1] Servicio de Reumatología, Grupo de Proteómica, ProteoRed/ISCIII, INIBIC-Hospital Universitario A Coruña. C/As Xubias S/N. 15.006, A Coruña, Spain [2] Catedra Bioibérica-Universidade da Coruña. Hospital Universitario A Coruña. C/As Xubias S/N. 15.006, A Coruña, - - 2014
Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the OA joint. Quantitative proteomics technologies are demonstrating a very interesting power for studying the molecular effects of some drugs currently used ...
Muramoto David - - 2013
To augment data guiding thresholds for myocardial ischemia and cardiac risk, we studied resting ST amplitude in ambulatory patients and collegiate athletes. We analyzed 4041 ECGs from ambulatory visits at the Veterans Affairs in Palo Alto, California from 1997 to 1999 and 1114 screening ECGs from Stanford University athletes in ...
Tang Yurong - - 2013
Ag nanoclusters (NCs) possessed distinct physical and chemical attributes that made them excellent scaffolds for the development of novel bio-analytical methodology. In the present work, a green approach for the preparation of Ag nanoclusters (NCs) was proposed on the basis of templated polyethyleneimine (PEI) assisted in-situ reductive crystallization of Ag ...
Volpi Nicola - - 2013
The evaluation of plasmatic galactosaminoglycans, dermatan sulfate (DS) and chondroitin sulfate (CS) can be helpful in the early identification of MPS patients, also considering that primary storage of one type of GAG can lead to secondary accumulation of other lysosomal substrates. We explore the possibility to determine plasmatic DS and ...
Cushman Mary - - 2013
Venous thromboembolism is the third leading cause of vascular death,(1) with a high incidence, especially among older persons. Incidence rates increase from 1 per 10,000 annually among persons less than 40 years of age to nearly 1% annually among persons 80 years of age or older(2); more than one third ...
Takeshita Rafaela Sayuri Cicalise - - 2013
Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are the most abundant steroid hormones in primates, providing a large reservoir of precursors for the production of androgens. DHEAS levels decline with age in adult humans and nonhuman primates, prompting its consideration as a biomarker of senescence. However, the mechanisms responsible for this ...
León-Muñoz Luz M - - 2013
PURPOSE: Prolonged sitting time (ST) is associated with higher mortality. However, previous studies used only a single measure of ST at baseline, so they could not directly assess the impact of continued exposure to high ST, or of changes in ST, on mortality. We prospectively assessed the association of continued ...
Williamson Kate A KA Cardiovascular Research Group, University of Manchester, 3rd Floor Core Technology Facility, 46 Grafton St., Manchester, M13 9NT, - - 2013
Aging poses one of the largest risk factors for the development of cardiovascular disease. The increased propensity toward vascular pathology with advancing age maybe explained, in part, by a reduction in the ability of circulating endothelial progenitor cells to contribute to vascular repair and regeneration. Although there is evidence to ...
Roy Partha - - 2013
PURPOSE: Paracetamol (acetaminophen, APAP) overdose is often fatal due to progressive and irreversible hepatic necrosis. The aim of this work was to design Andrographolide (AG) loaded nanoparticles to prevent similar hepatic necrosis. METHODS: Functionalized AG-loaded PLGA nanoparticles carrying different densities of heparin were prepared following a facile emulsion solvent evaporation ...
Urbanski Henryk F HF Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA. - - 2013
The adrenal steroid, dehydroepiandrosterone sulfate (DHEAS), is generally regarded as being a reliable endocrine marker of aging, because in humans and nonhuman primates its circulating concentrations are very high during young adulthood, and the concentrations then decline markedly during aging. Despite promising results from early studies, we were recently surprised ...
Abraham Preetha Anna - - 2013
Dehydroepiandrosterone sulfate (DHEAS) declines with age and low endogenous DHEAS concentrations have been associated with obesity. In addition, DHEAS has been studied for its role in mood and wellbeing. However, limited data are available on salivary DHEAS concentrations in African Americans. Thus, we examined age-related changes in morning salivary DHEAS ...
Hayes Anthony J - - 2013
Age-related degenerative changes within the vertebral column are a significant cause of morbidity with considerable socio-economic impact worldwide. An improved understanding of these changes through the development of experimental models may lead to improvements in existing clinical treatment options. The zebrafish is a well-established model for the study of skeletogenesis ...
Lee Hsu-Yi HY Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, - - 2013
The nanostructure and nanomechanical properties of aggrecan monomers extracted and purified from human articular cartilage from donors of different ages (newborn, 29 and 38 year old) were directly visualized and quantified via atomic force microscopy (AFM)-based imaging and force spectroscopy. AFM imaging enabled direct comparison of full length monomers at ...
Zduńczyk Sławomir - - 2012
The activities of steroid sulphatase (StS) and estrogen sulphotransferase (EST) were determined in the epididymis of 18 boars. The animals were divided into three groups (n=6) according to age (8, 12 and 16 months). The boars were anesthetized and castrated. The tissue samples of different epididymal parts (caput, corpus and ...
Storey Michael - - 2012
The Toba supereruption in Sumatra, ∼74 thousand years (ka) ago, was the largest terrestrial volcanic event of the Quaternary. Ash and sulfate aerosols were deposited in both hemispheres, forming a time-marker horizon that can be used to synchronize late Quaternary records globally. A precise numerical age for this event has ...
Sjögreen L - - 2012
Background: Earlier studies have shown that individuals with thalidomide embryopathy can have skeletal deformities, ear and eye aberrations, and facial palsy. This study aimed to survey the frequency and characteristics of facial palsy in this group of individuals. Participants: Thirty-one individuals with thalidomide embryopathy (age range, 45-47 years) and 25 ...
Firat Penpe Gul - - 2012
BACKGROUND: The aim of this study was to evaluate the macular thickness (MT), ganglion cell complex (GCC), and circum-papillary retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) with spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 169 subjects were enrolled: ...
Vajaranant Thasarat S - - 2012
The aim of this study was to provide a comprehensive review on hormone-based pathophysiology of aging of the optic nerve and glaucoma, including a literature review and expert opinions. Glaucoma, a group of intraocular pressure-related optic neuropathies, is characterized by the slow progressive neurodegeneration of retinal ganglion cells and their ...
Clayton Lisa M - - 2012
PURPOSE: To explore the relationship of peripapillary retinal nerve fiber layer (ppRNFL) thinning in individuals exposed to the antiepileptic drug vigabatrin with respect to 2 separate variables: cumulative vigabatrin exposure and severity of vigabatrin-associated visual field loss (VAVFL). DESIGN: Cross-sectional observational study. PARTICIPANTS: Subjects were older than 18 years, 129 ...
Guggenberger Roman - - 2012
Purpose:To determine normative diffusion values of the median nerve at several anatomic locations in healthy men and women of variable age and to compare these normative values with those in patients with carpal tunnel syndrome.Materials and Methods:After ethics board approval and written informed consent were obtained, 45 healthy volunteers (30 ...
Kang Sang-Hoon - - 2012
OBJECTIVE: We sought to standardize 3-dimensional anatomic positioning of the mandibular foramen (MnF) for inferior alveolar nerve block anesthesia. STUDY DESIGN: Three-dimensional mandibular computerized tomography (CT) images were reconstructed from data for 49 patients aged 8-16 years (growth group) and 59 patients aged 18-25 years (adult group). To measure MnF ...
Sueblinvong Viranuj - - 2012
Idiopathic pulmonary fibrosis (IPF) is a devastating progressive lung disease with an average survival of only 3 to 5 years. The mechanisms underlying the initiation and progression of IPF are poorly understood, and treatments available have only modest effect on disease progression. Interestingly, the incidence of IPF is approximately 60 ...
Heldal Anne Taraldsen - - 2012
To assess age- and sex-specific myasthenia gravis (MG) occurrence and incidence in the different geographical regions in Norway and thereby to identify factors that may contribute to the development of MG. Multiple Poisson regression analysis was used to assess variation in incidence dependent on year, gender and onset age in ...
Qiu Huai Yu - - 2012
To determine the etiology of optic neuritis in patients of different ages in China. Records of optic neuritis patients who were hospitalized in the Department of Neuro-ophthalmology, General PLA Hospital, Beijing, between January 1, 2011 and December 31, 2011 were retrospectively reviewed. A total of 132 patients were divided into ...
Tsai Der-Chong - - 2012
PURPOSE: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal schoolchildren with spectral domain optical coherence tomography (SD-OCT), and to evaluate the effects of age, spherical equivalent (SE) refraction, OCT signal strength, and cycloplegic treatment on RNFL thickness. METHODS: Comprehensive ophthalmic examinations were performed at a school ...
Lee Jong Yeon - - 2012
To evaluate the association between age and peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) spectral domain optical coherence tomography (OCT) in healthy Korean subjects. A total of 302 eyes from 155 healthy Korean subjects (age range, 20 to 79 years) underwent RNFL thickness measurements using ...
Cai Yan - - 2012
The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β -secretase (BACE1) and γ-secretase complex. However, extracellular Aβ deposition occurs ...
Velemínská J - - 2012
Sexual dimorphism is responsible for a substantial part of human facial variability, the study of which is essential for many scientific fields ranging from evolution to special biomedical topics. Our aim was to analyse the relationship between size variability and shape facial variability of sexual traits in the young adult ...
Boyle D J - - 2012
: Conflicting data exist on the contributions of advancing age and childbirth on the structure and function of the anal sphincter. This study aimed to examine the relative contributions of age and childbirth in a large cohort of women referred for investigation of symptoms of colorectal dysfunction (fecal incontinence and ...
Ubogu Eroboghene E EE Neuromuscular Immunopathology Research Laboratory, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. - - 2012
The objective of this study was to define the behavioral, electrophysiological, and morphological characteristics of spontaneous autoimmune peripheral polyneuropathy (SAPP) in female B7-2 deficient non-obese diabetic (NOD) mice. A cohort of 77 female B7-2 deficient and 31 wild-type control NOD mice were studied from 18 to 40 weeks of age. ...
Kang Woo Seok - - 2012
OBJECTIVES/HYPOTHESIS: To assess the normative size of the cochlear nerve (CN) and facial nerve (FN) in normal-hearing ears and to determine whether nerve size varies with age. STUDY DESIGN: Cross-sectional. METHODS: We included 169 ears with normal hearing between 2005 and 2010. The height, width, and cross-sectional area (CSA) of ...
Yuan Qiuju - - 2012
Post-injury nerve regeneration of the peripheral nervous system declines with age, but the mechanisms underlying the weakened axonal regeneration are not well understood. Increased synthesis and activity of the AP-1 transcription factor c-Jun have been implicated in efficient motor axonal regeneration. In the present study, we evaluated the hypothesis that ...
He L - - 2012
The peripheral taste system remains plastic during adulthood. Sectioning the chorda tympani (CT) nerve, which sends sensory information from the anterior tongue to the central nervous system, causes degeneration of distal fibers and target taste buds. However, taste function is restored after about 40 days in young adult rodents. We ...
Verdier Valérie - - 2012
Both the central and the peripheral nervous systems are prone to multiple age-dependent neurological deficits, often attributed to still unknown alterations in the function of myelinating glia. To uncover the biological processes affected in glial cells by aging, we analyzed gene expression of the Schwann cell-rich mouse sciatic nerve at ...
Robert L - - 2012
Skin is the most voluminous organ of the body. It assumes several important physiological functions and represents also a "social interface" between an individual and other members of society. This is the main reason its age-dependent modifications are in the forefront of dermatological research and of the "anti-aging" cosmetic industry. ...
Nag T C - - 2012
We examined age-related changes in the human optic nerve (ON) from 10 postmortem donor eye samples (age: 21- to 94-year-old). In aged ON, many axons showed paucity of cytoskeleton, and possessed disorganized myelin that remained in the extracellular space. Lipid inclusions were detected in glia, as stained by oil red ...
Xing Yazhi - - 2012
Age-related hearing loss (presbyacusis) is the most common type of hearing impairment. One of the most consistent pathological changes seen in presbyacusis is the loss of spiral ganglion neurons (SGNs). Defining the cellular and molecular basis of SGN degeneration in the human inner ear is critical to gaining a better ...
Shiba Tomoaki - - 2012
To determine whether there is a significant correlation between optic nerve head circulation determined by pulse wave analysis of laser speckle flowgraphy (LSFG), and the cardio-ankle vascular index (CAVI), left ventricular (LV) function, and age. Forty-nine men who visited the Vascular Function Section of Toho University Sakura Medical Center, Chiba, ...
Malik A A Department of Ophthalmology Government Medical College and Hospital, Chandigarh, India. - - 2012
Measuring the thickness of the retinal nerve fiber layer is a potential method of recognizing axon loss prior to the visual field abnormality. To study normal individuals to quantify peripapillary retinal nerve fiber layer (RNFL) thickness in Asian Indian subjects. This was a prospective study of 150 normal subjects. Peripapillary ...
Vos P A J M - - 2011
OBJECTIVES: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence chondrocyte activity. In clinical ...
Bedel Laurent - - 2012
Structural properties of SiO(x)C(y)-Ag nanocomposite thin films prepared by a dual process PVD-PECVD in the same reactor have been investigated. The experimental results have demonstrated the influence of a PECVD process carried out at room temperature for the growth of a dielectric matrix on the size and the distribution density ...
Nguyen Uyen-Sa D T - - 2011
A recent surge in knee replacements is assumed to be due to aging and increased obesity of the U.S. population. To assess whether age, obesity, and change in radiographic knee osteoarthritis explain the trend in knee pain and osteoarthritis. Cross-sectional, using data from 6 NHANES (National Health and Nutrition Examination ...
Fritze Olaf - - 2011
Background: Age-related arterial alterations affecting cells, matrix and biomolecules are the main culprit for initiation and progression of cardiovascular disease. The objective of this study is to gain further insights into the complex mechanism of elastic tissue ageing in human aortic blood vessels. Methods: One hundred and nineteen human aortic ...
Trivedi Arjun - - 2011
OBJECTIVES: To investigate the effect of hemolysis and protease inhibitors on acylated ghrelin (AG) concentrations measured with a double antibody enzyme immunometric assay that uses an acetylcholinesterase (AChE)-Fab' conjugate. DESIGN AND METHODS: Samples were hemolysed or treated with PHMB (p-hydroxymercuribenzoate), PMSF (phenylmethanesulfonylfluoride) or AEBSF (4-(2-Aminoethyl) benzenesulfonyl fluoride) to prevent AG ...
Short Lindsey A - - 2012
The human face provides a wealth of information pertaining to the internal state and life-stage history of an individual. Facial width-to-height ratio is a size-independent sexually dimorphic trait, and estimates of aggression made by untrained adults judging own-race faces were positively associated with both facial width-to-height ratio and actual aggressive ...
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