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Blaydon Diana C DC Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United - - 2011
We performed genetic and immunohistochemical studies in a sister and brother with autosomal recessive neonatal inflammatory skin and bowel lesions. The girl died suddenly at 12 years of age from parvovirus B19-associated myocarditis; her brother had mild cardiomyopathy. We identified a loss-of-function mutation in ADAM17, which encodes a disintegrin and ...
Li Yan - - 2011
Few studies have described the age-related changes in both peripheral and central systolic blood pressures (SBPs) in populations. We addressed this issue in 1066 women and 978 men, all untreated (mean age, 45.1 years; 27.2% hypertensive) and randomly selected from a Chinese population, of whom 369 and 330 underwent a ...
Liguz-Lecznar Monika - - 2011
Matrix metalloproteinase (MMP) activity is implicated in the degradation of the extracellular matrix during cerebral ischemia. Although many studies have demonstrated spatiotemporal patterns of activation of gelatinases (MMP-9 and MMP-2) after ischemic stroke in young adult rodents, no data exist on MMP activity in old brains. In this study, we ...
Leong Daniel J - - 2011
It is well accepted that aging is one of the most prominent risk factors for the initiation and progression of osteoarthritis. One of the most pronounced age-related changes in chondrocytes is the exhibition of a senescent phenotype, which is the result of several factors including the accumulation of reactive oxygen ...
Colín-González Ana Laura - - 2011
Different garlic products reduce the cerebral ischemic damage due to their antioxidant properties. In this work, we investigated the effect of aged garlic extract (AGE) on cyclooxygenase-2 (COX-2) protein levels and activity, and its role as a possible mechanism of neuroprotection in a cerebral ischemia model. Animals were subjected to ...
Harten Ingrid A - - 2011
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, progressive segmental premature aging disease that includes scleroderma-like skin, progressive joint contracture, and atherosclerosis. Affected individuals die prematurely of heart attacks or strokes. Extracellular matrix dysregulation is implicated as a factor in disease progression. We analyzed messenger RNA and protein levels for matrix ...
Hiraiwa Hideki - - 2011
OBJECTIVE: To investigate the inflammatory effects of advanced glycation end-products (AGEs) through the receptor for AGE in meniscal cells from osteoarthritic knees, and examine effects of hyaluronan (HA) on AGE-induced inflammation. METHODS: Meniscal cells from human osteoarthritic knees were cultured with or without glycolaldehyde-AGE-bovine serum albumin and 800 kDa HA. The ...
Joa Kyung Lim - - 2011
To understand the neural generator of double-peak potentials and the change of latency and amplitude of double peaks with aging. In 50 healthy subjects made up of groups of 10 people per decade from the age of 20 to 60, orthodromic sensory nerve conduction studies were performed on the median ...
Zigouris Andreas - - 2011
The present study investigates the histological alterations and expression of matrix metalloproteinase 9 (MMP-9) in disc specimens of 43 patients who underwent surgery for lumbar disc herniation. The immunostaining for MMP-9 was evaluated semi-quantitatively. Histologic degeneration was scored between 0 and 12 depending on the degree of chondrocyte proliferation and ...
Cochran Rory - - 2011
The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat OP poisoning involves an oxime reactivator (2-PAM, obidoxime, TMB4, or HI-6) combined with atropine and on occasion an anticonvulsant. Butyrylcholinesterase, administered ...
Wang Xiaoyu - - 2011
CCN-2, also known as connective tissue growth factor (CCN-2/CTGF) is a cysteine rich, extracellular matrix protein that acts as a pro-fibrotic cytokine in tissues in many diseases, including in diabetic nephropathy. We have published that soluble advanced glycation end products (AGEs), that are present in increased amounts in diabetes, induce ...
Zhou Shuanhu - - 2011
Human bone marrow stromal cells (hMSCs) have the potential to differentiate into osteoblasts; there are age-related decreases in their proliferation and differentiation to osteoblasts. Parathyroid hormone (PTH), when applied intermittently in vivo, has osteoanabolic effects in a variety of systems. In this study, we compared PTH signaling and osteoanabolic effects ...
Naylor Elizabeth C - - 2011
Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes in cutaneous cells, the ...
Chiossi Giuseppe - - 2011
The objective of this study was to investigate vascular function at different ages in a transgenic murine model of fetal vascular programming using a model of uteroplacental insufficiency induced by lack of endothelial nitric oxide synthase. Homozygous NOS3 knockout (KO) and wild-type (WT) mice were cross bred to produce WT, ...
Sauvet Fabien - - 2011
INTRODUCTION: Laser-Doppler flowmetry (LDF) coupled with acetylcholine chloride (ACh) iontophoresis is increasingly recognized as a reliable non-invasive method to study the endothelial function. However, ACh-vasodilation measurement appears highly variable possibly due to the ACh pharmacological properties itself. These problems may be partially overcome by using methacholine chloride (MCh), a more ...
Bruckner Anna L - - 2011
Epidermolysis bullosa (EB) is a family of rare, heterogeneous, genetic disorders characterized by fragility of the skin and mucous membranes. Reduced bone mass and fractures have been recognized as complications of generalized forms of EB. We sought to describe the range and to estimate the prevalence of low bone mass ...
Chang Li-Ching - - 2012
Various factors affect the central maxillary incisor papilla height (PH) and central clinically observable PH (COPH) such that a study of these factors and their interactions is needed. This study reports on an investigation of the factors associated with PH and COPH in patients with and without papilla recession. The ...
Chen H - - 2011
Despite increasing interest in age- and gender-related bone alterations, data on trabecular microstructure at the proximal tibia are scarce. The aim of this study was to identify trabecular microstructural change at the human proximal tibia with age and gender, using micro-computed tomography (micro-CT) and scanning electron microscopy (SEM). Fifty-six proximal ...
Katzmarzyk Peter T PT Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA. - - 2012
Several studies have documented relationships between adipose tissue and bone mineral density (BMD); however, the degree to which there are racial differences in this relationship is not known. The purpose of this study was to examine the relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and ...
Gracco Antonio - - 2011
OBJECTIVE: To verify, via CBCT, the existence of a definable distance for bodily intrusion of maxillary incisors, and its correlation to age, sex and/or facial biotype. MATERIALS AND METHODS: The sample consisted of sagittal sections obtained from 79 CBCTs of 220 maxillary incisors correctly aligned on their osseous base (maxillary ...
L'abbé E N - - 2011
Establishing ancestry from a skeleton for forensic purposes has been shown to be difficult. The purpose of this paper is to address the application of thirteen non-metric traits to estimate ancestry in three South African groups, namely White, Black and "Coloured". In doing so, the frequency distribution of thirteen non-metric ...
Baxter-Jones A D G - - 2011
Bone area (BA) and bone mineral content (BMC) were measured from childhood to young adulthood at the total body (TB) lumbar spine (LS), total hip (TH) and femoral neck (FN). BA and BMC values were expressed as a percentage of young adult values to determine if and when values reached ...
Dong X Neil - - 2011
Advanced glycation end products (AGEs) have been observed to accumulate in bone with increasing age and may impose effects on bone resorption activities. However, the underlying mechanism of AGEs accumulation in bone is still poorly understood. In this study, human cortical bone specimens from young (31±6years old), middle-aged (51±3years old) ...
Cohen-Kettenis Peggy T - - 2011
Puberty suppression by means of gonadotropin releasing hormone (GnRH) analogs is considered a diagnostic aid in gender dysphoric adolescents. However, there are also concerns about potential risks, such as poor outcome or post-surgical regret, adverse effects on metabolic and endocrine status, impaired increment of bone mass, and interference with brain ...
Baumbach S F - - 2011
PURPOSE: The aim of the study was to investigate possible linear intra-bone geometry dependencies by determining the relation between the maximum radius length and maximum distal width in two independent populations and test for possible gender or age effects. A strong correlation can help develop more representative fracture models and ...
Anliker Elmar - - 2011
PURPOSE:: To assess maximum voluntary forefoot ground reaction force (Fm1LH) during multiple one-legged hopping (m1LH, a new jumping maneuver) and to determine the correlation between tibial volumetric bone mineral content (vBMC, a valid surrogate of bone strength) and Fm1LH. METHODS:: One hundred and eighty-five females (8-82 years old) and 138 ...
Dall'ara Enrico - - 2011
This study investigated whether changes in hardness of human trabecular bone are associated with osteoarthritis. Twenty femoral heads extracted from subjects without musculoskeletal diseases (subject age: 49-83 years) and twenty femoral heads extracted from osteoarthritic subjects (subject age: 42-85 years) were tested. Sixty indentations were performed along the main trabecular ...
Perry Jamie L - - 2011
The purpose of this study was to assess displacement of oropharyngeal structures, particularly the hyoid bone and velum, and variations in timing of the pharyngeal stage of swallowing in the upright versus the supine position. Twelve Caucasian adult subjects between 19 and 27 years of age participated. Subjects were recorded swallowing ...
Hsieh Chi-Wen - - 2011
Background: The Tanner-Whitehouse III (TW3) method, popular for assessing children's bone age, is time-consuming in clinical settings; to depress this, a grouped-TW algorithm (GTA) was developed. Methods: Five hundred and thirty-four left-hand roentgenograms of individuals aged 2-15 years, including 270 training and 264 testing datasets, were evaluated by a senior ...
Kim Taehun - - 2011
We performed a monozygotic (MZ) cotwin-control study using the MZ twin pair difference in bone mineral density (BMD) to assess the relationship between body composition and BMD at weight-bearing sites. This study controlled for common genetic factors and applied only to environmental factors, using 185 MZ twin pairs aged 30-50 years ...
Rose Susan R - - 2011
BACKGROUND: Conflicting data exist regarding whether low bone mineral density (BMD) is associated with Fanconi anemia (FA). The current study identified the frequency of low BMD in FA, expecting low BMD even in childhood and before HCT. PROCEDURE: Thirty-seven FA patients (18 prior HCT, 19 no prior HCT), participating in ...
Thompson Jessica C JC School of Social Science, Archaeology Program, The University of Queensland, Brisbane QLD 4072, Australia. - - 2011
A detailed taphonomic analysis is reported for a sample of the larger mammalian faunal assemblage (>4.5 kg live body weight) from Blombos Cave. The analysis provides an assessment of human involvement in the accumulation and modification of the faunal assemblage, and precedes equally detailed analyses and separate reports of Middle Stone ...
Wang Yi-Xiang J - - 2011
To study the relationship between hip bone mineral density (BMD), lumbar disc degeneration, and lumbar disc space narrowing in elderly subjects. The study cohort comprised 196 females and 163 males (age range, 67-89 years) with no age difference between the two groups. Anteroposterior total hip areal BMD was measured with ...
Cutti P - - 2011
Background College age female athletes are susceptible to decreased bone mineral density (BMD) which puts them at an elevated risk for poor bone health in the future. Objective The primary purpose of this study was to compare site-specific and total body BMD of college-age female athletes across sports of varying ...
Perillo L - - 2011
Whether there are correlations between the stomatognathic system and body posture remains controversial. Here, we have investigated whether malocclusal traits and having a Helkimo Index ≥ 5 show detectable correlations with body-posture alterations in children and young adults. A total of 1178 11- to 19-year-old subjects were divided into four ...
Woestenenk Janna W - - 2011
BACKGROUND: Height is a strong prognostic factor in cystic fibrosis (CF) and is usually compared to reference values of healthy children by expressing height as a z-score height-for-age (HFA). However, HFA does not take into account a potential delay in bone age (BA) and the genetic potential of the child ...
Siilin Helene - - 2011
BACKGROUND: Age and sex are of importance in the development of primary hyperparathyroidism (PHPT), and the disease is most common in postmenopausal women. Skeletal complications are well known at an advanced stage of PHPT, although the impact on bone mineral density (BMD) is evident in patients with mild disease. This ...
Marttinen Risto H J - - 2011
Marttinen, RHJ, Judelson, DA, Wiersma, LD, and Coburn, JW. Effects of self-selected mass loss on performance and mood in collegiate wrestlers. J Strength Cond Res 25(X): 000-000, 2011-Wrestlers abruptly lose body mass before competition; however, the effects of "weight cutting" are poorly understood because of conflicting evidence. This study aimed ...
Pirgon Ozgur - - 2011
Aim:  The aim of this study was to investigate the relationships between bone mineral density (BMD) versus insulin resistance and metabolic risk factors in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Patients and methods:  82 obese adolescents (45 girls and 37 boys, mean age: 12.3 ± 1.7 years, mean ...
Fonseca H - - 2011
The aim of the present study was to analyze the lifelong differences of femur structure in sedentary and physically active animal models. Thirty male C57BL/6 mice, 2 months old, were either: i) housed in cages with running wheel (AA; n=10), ii) housed in cages without running wheel (AS; n=10), iii) ...
Gefen Ron - - 2011
OBJECTIVE: Hyperintense areas of vertebral bone marrow on fluid-sensitive sequences are at times seen on pediatric MRI of the cervical spine in children without suspicious clinical conditions to explain marrow pathology. Although these likely have no clinical significance they may be mistaken for pathology. The purpose of this study is ...
Tritos Nicholas A - - 2011
Context: GH deficiency (GHD) is associated with low bone mineral density (BMD). Risk factors for lower BMD in this GHD population have not been fully elucidated. In particular, there are limited published data in GH-naïve subjects. Objective: The objective of the study was to identify endocrine correlates of low BMD ...
Sheng Zhifeng - - 2011
Objectives  To elucidate the relationship between body composition and bone mineral density (BMD) and the prevalence of osteoporosis in central south Chinese postmenopausal women. Methods  A cross-sectional study was conducted on 954 healthy central southern Chinese postmenopausal women, aged 50-82. Total body, lumbar spine and left femur BMD and total ...
Kim Sung-Tae - - 2011
These cortical and trabecular bones maintain general bone structure. Bone mineral density (BMD) changes according to increasing age, sex, and teeth loss. From previous studies, the evaluation of BMD changes depended on conventional radiographic analysis. This study investigated the trabecular bone ratio (TBR) in maxillary bone samples based on data ...
Makrai László - - 2011
Enterococcus cecorum is the most frequently occurring enterococcal species in the intestine of chickens of over 12 weeks of age, and there are few reports on its isolation from the skeleton of broiler parent chicks. In the present study, observations on vertebral osteomyelitis and spondylolisthesis ('kinky back syndrome') showing high ...
Suri Sunjay - - 2011
To (1) document the prevalence and patterns of hypodontia (permanent tooth agenesis) in Down syndrome (DS) and (2) explore whether maxillary or mandibular hypodontia or simultaneous agenesis of all third molars was associated with differential alterations of the craniofacial morphology. Longitudinal panoramic radiographs of 25 white patients with DS (12 ...
Swarnkar Gaurav - - 2011
(2S,3S)-aromadendrin-6-C-β-D-glucopyranoside (AG) is a novel flavonol isolated from the extract of Ulmus wallichiana (Himalayan Elm). Extract of U. wallichiana is used as a traditional medicine for rapid fracture repair in India. We characterized the mechanism of action of AG in mouse bone cells by investigating its effect on the precursors ...
Hwang Kyung-A - - 2011
Skin is the most superficial body organ and plays an important role in protecting the body from environmental damage and in forming social relations. With the increase of the aging population in our society, dermatological and cosmetic concerns of skin aging are rapidly increasing. Skin aging is a complex process ...
Jackowski Stefan A - - 2011
A higher bone mass may reduce the risk of osteoporosis and fractures. The role of maturational timing for optimizing bone mass is controversial due to the lack of prospective evidence from childhood to adulthood. The purpose of this study was to examine the long term relationship between the onset of ...
Grün Rainer - - 2011
We present a detailed description of the geological setting of the burial site of the WLH 50 human remains along with attempts to constrain the age of this important human fossil. Freshwater shells collected at the surface of Unit 3, which is most closely associated with the human remains, and ...
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