Glycation, a non-enzymatic addition of reducing sugars to ε-amino groups of proteins, is a post-translational modification that results in the formation of irreversible advanced glycation end products (AGEs). Ageing related decline in myofibrillar protein function is effected by a number of structural and functional modifications including glycation. Functional properties of ...

SHORT LEUKOCYTE TELOMERE LENGTH (LTL) IS ASSOCIATED WITH ATHEROSCLEROSIS IN ADULTS AND: diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age-dependent LTL ...

Agonist to antagonist strength data is commonly analyzed due to its association with injury and performance. The purpose of this study was to examine the agonist to antagonist ratio of upper body strength using two simple field tests (timed push up/timed modified pull up) in recreationally active adults and to ...

There is limited empirical evidence regarding differences in sun protection practices in different regions of the USA. This study examined whether there are regional differences in the efficacy of exposure to UV photographs and photoaging information (e.g. wrinkles and age spots) for increasing sun protection behaviours. Students attending a public ...

Abstract Unlike the aging population without intellectual and developmental disabilities (IDD), few standardized performance measures exist to assess physical function and risk for adverse outcomes such as nonfatal, unintentional injuries. We modified 3 selected standardized performance tools in the areas of general fitness (2-Minute Walk Test), balance and gait (Performance-Oriented ...

Purpose: This study identifies clinical factors that predict multiple tooth loss in a socioculturally diverse population of older adults. Materials and Methods: A total of 193 participants from English-, Chinese-, or Punjabi-speaking communities in Vancouver, British Columbia, with low incomes and irregular use of dental services were followed for 5 ...

Longitudinal data on bone decline in ethnic Chinese elderly are sparse, especially in healthy, aged women. This study reviews the longitudinal change in bone mineral density (BMD) at the femoral neck, great trochanter, and Ward's triangle in healthy elderly Taiwanese women. A prospective cohort study was conducted, with 1500 women ...

ABSTRACT: In this study, we analyzed the key parameters of modified transcutaneous lower blepharoplasty based on multidisciplinary principles (biochemical findings and biophysical wrinkling theory). A total of 408 female patients received our subciliary lower blepharoplasty between March 2002 and January 2010. The severity of the eyebags (dynamic wrinkle numbers and ...

A preliminary inquiry, conducted on Martinique Island, sought to determine professional skippers' sun-protection knowledge and behavior. Fifty-two skippers (mean age: 41 years) completed a questionnaire; 39 (75 %) had a simple sunburn over the last 6 months and 3 (6%) severe sunburn; 54 (64%) declared achieving sun protection by wearing ...

The purpose of this study was to identify the risk factors associated with the masticatory dysfunction after maxillectomy using a colour-changing chewing gum. Thirty-nine patients who underwent maxillectomy between January 2002 and May 2010 in the Department of Kobe University Hospital were recruited for this study. There were 20 male ...

Impact of agriculture crop-residue burning (ACRB) was studied on pulmonary function tests (PFTs) of 50 healthy subjects (13-53 years). Human subjects with no previous history of lung disease were residents of five sampling sites. Investigations were carried out from February 2007 to January 2010 using spirometry. Simultaneously, concentration levels of ...

Tau protein could appear like a family of multiple isoforms rising by alternative splicing of its nuclear RNA or by different posttranslational modifications. The levels (or proportion) of these different tau isoforms could change in different neurons during development, aging or disease (tauopathies) in mammals. It is discussed that in ...

We evaluated the association of hearing loss with employment and income in adults. Patients with a coded diagnosis of hearing loss were identified from the 2006 and 2008 Medical Expenditure Panel Survey linked household and medical conditions files and compared to patients without hearing loss. Differences in employment, wage income, ...

Bait-trapping appears to be a generally useful method of studying fly populations. The aim of this study was to construct a new adult flytrap by some modifications in former versions and to evaluate its applicability in a subtropical zone in southern Iran. The traps were constructed with modification by adding ...

Racemisation is one of the most abundant modifications in long-lived proteins. It has been proposed that the accumulation of such modifications over time could lead to changes in tissues and ultimately human age-related diseases. Serine is one of the main amino acids involved in racemisation, however the site of D-Ser ...

The male of Hymenoepimecis japi (Hymenoptera, Ichneumonidae, Pimplinae) is described and illustrated. The specimen was collected in a modified web (cocoon web) of Leucauge roseosignata (Araneae, Tetragnathidae) made in a laboratory. Both, host and parasitoid were collected in Reserva Biológica Serra do Japi, located in Jundiaí, São Paulo, Brazil.

Background: Patterns and ease of stair ambulation influence amputees' level of satisfaction with their rehabilitation, confidence level, and motivation for continued rehabilitation, demonstrating the importance of stair-ascent data for rehabilitation. However, little is known about the determinants of stair-ascent patterns in unilateral transfemoral amputees.Objectives: To investigate the factors affecting stair-ascent ...

Aim: Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP genes polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects. ...

Objective: To update a 15-year-old study of 800 postlinguistically deaf adult patients showing how duration of severe to profound hearing loss, age at cochlear implantation (CI), age at onset of severe to profound hearing loss, etiology and CI experience affected CI outcome. Study Design: Retrospective multicenter study. Methods: Data from ...

OBJECTIVE: Stressful life events (SLE) have been associated with increased dementia risk, but their association with cognitive decline has been inconsistent. In a longitudinal population-based study of older individuals, we examined the association between SLE and cognitive decline, and the role of potential effect modifiers. METHODS: A total of 2665 ...

Background HIV infections among men who have sex with men (MSM) are increasing in Japan. Method: An anonymous self-administered questionnaire among clients of a gay bar in Osaka was used to analyse the relationship between age and unprotected anal sex (UAI). Results: The highest rate of UAI was reported among ...

Humans undergo biological ageing at different rates. This associates with functional decline in a number of physiological systems and increasing incidence of age-related pathologies. The discovery of robust biomarkers of ageing could be used to identify early divergence from a path of healthy ageing towards age-related disease. In the present ...

Total mercury levels in different feather types (down, contour, tail and flight) in Great Cormorants (Phalacrocorax carbo L.) were determined using CV-AAS. Feathers from Great Cormorants inhabiting the Vistula Lagoon ecosystem have an average Hg level of 7.14 ± 3.99 (μg/g w.w.). Age-dependent concentrations of Hg were statistically significant (ANOVA ...

Purpose: To investigate the prevalence of visual impairment in a rural northern Chinese population. Methods: A cross-sectional, population-based survey was conducted in 2010 in Ci County, Hebei Province in northern China. Residents aged 7 years and older in Lucunying Town, located within Ci County, underwent presenting visual acuity (VA) testing ...

Uncertainties surround the timing of modern human emergence and occupation in East and Southeast Asia. Although genetic and archeological data indicate a rapid migration out of Africa and into Southeast Asia by at least 60 ka, mainland Southeast Asia is notable for its absence of fossil evidence for early modern ...

OBJECTIVES: To determine the life expectancy and mortality rates in patients with type 2 diabetes mellitus when compared with the UK general population; to measure the years of life lost. DESIGN: Longitudinal and retrospective cohort study. SETTING: The Wirral Peninsula in the northwest of England. PARTICIPANTS: Total of 13 620 patients ...

ABSTRACT: BACKGROUND: Previous studies report association of contraceptives with moderate increase in urinary tract infection among sexually active premenopausal women. The aim of our study was to find out whether the use of hormonal contraceptives has any effect on microbiota of the vagina in the contraceptives users in Khairpur Sindh ...

C(U)RB-65 is now a generally accepted severity score for patients with community-acquired pneumonia (CAP) in Europe.In an observational study based on the large database from the German nationwide performance measurement program in healthcare quality including data from all hospitalised patients with CAP during 2008-2010, different CRB-age groups across the total ...

Highly fluorescent Ag nanoclusters (NCs) were successfully prepared by a simple and nontoxic approach, and the as-prepared Ag NCs could be utilized for the AFu detection with a lower detection limit of 0.001 U L(-1).

OBJECTIVE: The goal of this study was to determine the relationship between age and risk for depression among the old and the oldest old. Method MEDLINE, EMBASE, and the Cochrane Library database were used to identify potential studies. The studies were divided into cross-sectional and longitudinal subsets. For each study, ...

Objectives:To estimate the prevalence and determinants of obesity in childhood and adolescence and their association with blood pressure (BP) in Abu Dhabi, United Arab Emirates (UAE).Design:A cross-sectional population-representative study.Subjects:A total of 1541 students (grades 1-12; aged 6-19 years) were randomly selected from 246 schools (50% male). Anthropometric and demographic variables ...

BACKGROUND: The objective of this study was to determine the prevalence of Parkinson's disease (PD) among American Indian and Alaska Native (AI/AN) people. METHODS: We analyzed records for AI/AN people between 2002 and 2009 using inpatient and outpatient visit data from the Indian Health Service. Crude and age-adjusted prevalence, using ...

Age-related cataract (ARC) is the leading cause of blindness among older adults, and the chaperone-like activity of αA-crystallin (CRYAA) is considered to be critical for the maintenance of eye lens transparency. To assess the potential contribution of epigenetic regulation of CRYAA genes relevant to ARC pathogenesis, we evaluated DNA methylation, ...

To investigate the critical period for overweight development during early childhood by examining growth trajectory and related sex differences. Using piecewise linear mixed models and logistic regression, we examined the effect of growth trajectory at different periods on overweight at age 4-5 by sex among 13,6 971 regularly followed children (mean: ...

Intralocus sexual conflict (IASC) occurs when a trait under selection in one sex constrains the other sex from achieving its sex-specific fitness optimum. Selection pressures on body size often differ between the sexes across many species, including humans: among men individuals of average height enjoy the highest reproductive success, while ...

BACKGROUND: The use of proton pump inhibitors (PPIs) is thought to increase the incidence of microscopic colitis (MC), although the exact mechanisms are not fully understood. Increased infiltration of intraepithelial lymphocytes (IELs) is a pathologic finding of MC (including collagenous or lymphocytic colitis). AIMS: We investigated whether PPI use is ...

The spatial distribution of Atlantic salmon Salmo salar young-of-the-year (0+) and 1 year old parr (1+) from the 2006 spawning cohort in a 5125 m reach of the River Skauga in central Norway was documented. A high degree of similarity was found between the distribution of 0+ and 1+ parr ...

Comment on: Pirazzini C, Giuliani C, Bacalini MG, Boattini A, Capri M, Fontanesi E, Marasco E, Mantovani V, Pierini M, Pini E, Luiselli D, Franceschi C. Garagnani P. Space/Population and Time/Age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and ...

The majority of studies on youth violence have focused on factors that increase the risk for youth violence. To assess whether determinants of violence operate as risk factors, direct protective factors, or both during adolescence and young adulthood. Data from participants in the National Longitudinal Study of Adolescent Health, aged ...

Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood ...

ABSTRACT: Whole-genome methylation analysis of newborns and centenarians reveals widespread epigenetic alterations, and provides new insight into age-related methylation pattern changes.

Objective: To examine the value of the Conners 10-item scale to predict academic outcomes at age 16 years in schoolchildren aged 7 and 10 years. Method: A cohort study of N = 544 children in a municipality of Stockholm County was conducted. Using the parent and teacher version of the ...

Purpose:To examine prevalence of refractive errors and its associated factors, such as body stature and educational level, among 19-year-old males in Seoul, Korea. Methods:A population-based cross-sectional study was performed in male subjects (n = 23,616; age = 19 years) who were normally resident in Seoul for male compulsory conscripts during ...

The distal half of a right human humerus (E.898), recovered ex situ in 1925 by Hrdlička at the Broken Hill Mine, Kabwe, Zambia, has figured prominently in assessments of Middle Pleistocene Homo postcranial variation and of the phylogenetic polarity and functional anatomy of Pleistocene Homo upper limb morphology. Reassessment of ...

Background. More than 90% of genital warts (GW) cases are caused by human papillomavirus (HPV) types 6 and 11. The introduction of HPV vaccines necessitates the estimation of the population-based incidence of GW immediately before and after vaccination uptake.Methods. Incidence proportions were calculated using the entire population aged 10-44 years living in ...

Background: Female sex has been suggested as a risk factor for stroke/thromboembolism in patients with non-valvular atrial fibrillation (AF) and therefore been included within risk scores, e.g. the CHA(2) DS(2) -VASc score, and guidelines. Objectives: We investigated the risk of stroke/thromboembolism associated with female sex in non-valvular AF patients. Patients/Methods: ...

The Paisley Caves in Oregon record the oldest directly dated human remains (DNA) in the Western Hemisphere. More than 100 high-precision radiocarbon dates show that deposits containing artifacts and coprolites ranging in age from 12,450 to 2295 (14)C years ago are well stratified. Western Stemmed projectile points were recovered in ...

SUMMARY AT A GLANCE: This article demonstrates that low eGFR measured at the first day of admission of ischemic stroke is a good predictor of death. ABSTRACT: Aims:   Low estimated glomerular filtration rate (eGFR) is associated to high mortality after stroke. However, ageing can influence eGFR directly and limit ...

BACKGROUND: Triggering factors seem to be multiple in the pathogenesis of facial hyperpigmentation (FH), as dark skin types, pregnancy, sun exposure… OBJECTIVES: The aim of this study was to investigate the risk factors for facial hyperpigmentation in maghrebian population. MATERIAL AND METHODS: Patients with facial hyperpigmentation were included in a ...

The foramen magnum (FM) has been an integral component of studies on the ontogeny and evolutionary transformation of the skull. While its shape is variable in different species and breeds, the morphological variations and metrical indices of the foramen have scarcely been studied in camels. A total of 30 adult ...