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Otag I I Department of medical services, Vocational School of Health Services, Sivas, - - 2014
Background: Data on central region morphometry of a child brain is important not only in terms of providing us with information about central region anatomy of the brain but also in terms of the help of this information for the plans to be applied in neurosurgery. Objective: In the present ...
Maller Jerome J JJ 1 Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne Victoria, - - 2014
There are reports of differences in occipital lobe asymmetry within psychiatric populations when compared with healthy control subjects. Anecdotal evidence and enlarged lateral ventricles suggests that there may also be a different pattern of curvature whereby one occipital lobe wraps around the other, termed 'occipital bending'. We investigated the prevalence ...
Walhovd Kristine B KB Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Physical medicine and rehabilitation, Unit of neuropsychology, Oslo University Hospital, - - 2014
Changes in brain structure and activity as well as cognitive function are commonly seen in aging. However, it is not known when aging of brain and cognition starts, and how much of the changes observed in seemingly healthy older adults that can be ascribed to incipient neurodegenerative disease. Recent research ...
Poggesi Anna A Neuroscience Section, NEUROFARBA Department, University of Florence, Florence, - - 2014
To investigate the role of neurological abnormalities and magnetic resonance imaging (MRI) lesions in predicting global functional decline in a cohort of initially independent-living elderly subjects. The Leukoaraiosis And DISability (LADIS) Study, involving 11 European centres, was primarily aimed at evaluating age-related white matter changes (ARWMC) as an independent predictor ...
Oudekerk Barbara A BA University of Virginia, - - 2014
This study examined how age gaps among opposite-sex romantic partners related to sexual risk-taking and victimization by partners among 201 at-risk adolescents (60.2% female). We examined three questions: (a) is younger partner age, age gap between partners, or a combination of these two factors most strongly related to negative outcomes; ...
van Karnebeek Clara C Division of Biochemical Diseases, Department of Pediatrics, BC Children's Hospital, Vancouver, BC, V5Z 1M9, - - 2014
Deep brain stimulation (DBS) has been used to treat secondary dystonias caused by inborn errors of metabolism with varying degrees of effectiveness. Here we report for the first time the application of DBS as treatment for secondary dystonia in a 22-year-old male with X-linked adrenoleukodystrophy (X-ALD). The disease manifested at ...
Gildengers Ariel G AG Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, - - 2014
The aim of the present study was to examine the long-term effects of bipolar disorder (BD) on brain structure (gray matter volumes). Fifty-four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volumes were extracted ...
Li Xiaohua X pathology, Henan provincial Eye Hospital,1 Henan eye Institute,2 Department of Ophthalmology,3 Henan Provincial People's hospital,4 Department of Ophthalmology,5 Zhengzhou University People's hospital, pathology, Zhengzhou, 450003, - - 2014
Purpose:To analyze the age distribution of corneal disease in China by histopathological examination. Methods:Methods: A retrospective histopathological analysis of the age distribution of corneal disease was performed on corneal specimens from 3112 patients who underwent corneal surgery between 2001 and 2012 in Henan Eye Institute. Results:The distribution of the corneal ...
Koran Mary Ellen - - 2014
Individuals with Down Syndrome (DS) are reported to experience early onset of brain aging. However, it is not well understood how pre-existing neurodevelopmental effects versus neurodegenerative processes might be contributing to the observed pattern of brain atrophy in younger adults with DS. The aims of the current study were to: ...
Goh Suzanne S Department of Psychiatry, Columbia University Medical Center, New York, New - - 2014
IMPORTANCE Impaired mitochondrial function impacts many biological processes that depend heavily on energy and metabolism and can lead to a wide range of neurodevelopmental disorders, including autism spectrum disorder (ASD). Although evidence that mitochondrial dysfunction is a biological subtype of ASD has grown in recent years, no study, to our ...
Dean Douglas C DC 3rd Advanced Baby Imaging Laboratory, School of Engineering, Brown University, Providence, RI, 02912, USA, - - 2014
Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about ...
Nooijen Carla C Department of Rehabilitation Medicine and Physical Therapy, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands . - - 2014
Objective: To describe in detail the health-related physical fitness of adolescents and young adults with cerebral palsy, compared with able-bodied references, and to assess differences related to Gross Motor Functioning Classification System (GMFCS) level and distribution of cerebral palsy. Design: Cross-sectional. Subjects: Fifty ambulatory persons with spastic cerebral palsy, GMFCS ...
Miyagi Masayuki M 1Faculty of Dentistry, McGill University 2Alan Edwards Centre for Research on Pain 3McGill Scoliosis & Spine Research Group, McGill University 4Departments of Anesthesiology 5Pharmacology & Therapeutics, and 6Neurology & Neurosurgery, Faculty of Medicine, McGill University 7Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Study Design. Immunohistochemical and behavioral study using the SPARC-null mouse model of Low Back Pain (LBP) associated with accelerated Intervertebral Disc (IVD) degeneration.Objective. To determine if behavioral signs of LBP in SPARC-null mice are accompanied by sensory nervous system plasticity.Summary of Background Data. IVD pathology is a significant contributor to ...
Linton Kristen F KF Myron B. Thompson School of Social Work, University of Hawaii at Manoa , Honolulu, Hawaii , - - 2014
Abstract Primary objective: The purpose of this study was to compare the aetiology of TBI between different race, gender and age groups to understand demographic characteristics of people who experience TBI. Research design: A secondary data analysis of the Arizona Trauma Database consisting of 18 868 cases of TBI between 2008-2010 ...
Jack Clifford R CR Jr From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G., V.L., B.E.G.), Health Sciences Research (H.J.W., M.M.M., S.D.W., V.S.P.), and Neurology (D.S.K., R.C.P.), Mayo Clinic and Foundation, Rochester, - - 2014
To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration in a population-based sample. A total ...
Bamidis P D PD Group for Applied Neuroscience & Group for Assistive Technologies and Silverscience, Lab of Medical Physics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, PO Box 376, 54124, Thessaloniki, Greece. Electronic address: - - 2014
Maintaining a healthy brain is a critical factor for the quality of life of elderly individuals and the preservation of their independence. Challenging aging brains through cognitive training and physical exercises has shown to be effective against age-related cognitive decline and disease. But how effective are such training interventions? What ...
Esparza-Ros F F Chair of Sports Traumatology. University of San Antonio of Murcia, Murcia, - - 2014
A good control of the spinal posture may induce greater ability to change spinal angles in several positions. The spinal posture influences vertebral loading during daily activities. Neutral postures have been associated to lower spinal forces in the intervertebral joints. To compare the spinal posture and pelvic tilt between relaxed ...
Eramudugolla Ranmalee R 1 Centre for Research on Aging, Health and Wellbeing, Australian National University, - - 2014
There is continuing debate about long-term effects of brain injury. We examined a range of traumatic brain injury (TBI) variables (TBI history, severity, frequency, and age of injury) as predictors of cognitive outcome over 8 years in an adult population, and interactions with apolipoprotein E (APOE) genotype, sex, and age ...
Pasquini Lorenzo L Klinikum rechts der Isar, Technische Universität München, Neuroradiology, Munich, Germany ; - - 2014
In Alzheimer's disease (AD), recent findings suggest that amyloid-ß-pathology (Aß) might start 20-30 years before first cognitive symptoms arise. To account for age as most relevant risk factor for sporadic AD, it has been hypothesized that lifespan intrinsic (i.e. ongoing) activity of hetero-modal brain areas with highest levels of functional ...
Cadena-Del-Castillo Carla C Instituto de Fisiología Celular, Departamentos de Genética Molecular y, Universidad Nacional Autónoma de México, México D.F., México Neurociencia Cognitiva, Universidad Nacional Autónoma de México, México D.F., - - 2014
Alzheimer's disease (AD) is a complex disorder whose etiology is associated with environmental and genetic factors. Recently there have been several attempts to analyze the role of epigenetic alterations in the origin and progression of this neurodegenerative condition. To evaluate the potential participation of the methylation status of the genome ...
Kovacs Gabor G GG Institute of Neurology, Medical University of Vienna, Austria. Electronic address: - - 2014
The molecular and cellular mechanisms, which coordinate the critical stages of brain development to reach a normal structural organization with appropriate networks, are progressively being elucidated. Experimental and clinical studies provide evidence of the occurrence of developmental alterations induced by genetic or environmental factors leading to the formation of aberrant ...
Jaraj Daniel D From the Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry (D.J., T.M., I.S.), Hydrocephalus research unit, Department of Clinical Neuroscience and Rehabilitation (K.R., C.W.), Institute of Neuroscience and Physiology, Department of Radiology, Institute of Clinical Sciences (C.J.), Sahlgrenska Academy, University of Gothenburg, - - 2014
The aim of this study was to determine the prevalence of idiopathic normal-pressure hydrocephalus (iNPH) in elderly persons in a large population-based sample using radiologic and clinical examinations. We examined representative elderly populations aged 70 years and older that had undergone neuropsychiatric evaluations and CT of the brain between 1986 ...
Maitre Nathalie L - - 2014
Magnetic resonance imaging (MRI) is a useful tool to study brain growth and organization in preterm neonates for clinical and research purposes, but its practicality can be limited by time and medical constraints. The aim of this study was to determine if MRI relaxometry of the deep nuclei, as opposed ...
Sridharan Aadhavi A Neuroscience Training Program, University of Wisconsin-Madison, 1300 University Ave, Madison, WI 53706, USA; Medical Scientist Training Program, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53705, USA. Electronic address: - - 2014
The rhesus macaque exhibits age-related brain changes similar to humans, making an excellent model of normal aging. Calorie restriction is a dietary intervention that reduces age-related comorbidities in short-lived animals, and its effects are still under study in rhesus macaques. Here, using deterministic fiber tracking method, we examined the effects ...
Li Zengyong Z Key Laboratory of High Efficiency and Clean Mechanical Manufacture, School of Mechanical Engineering, Shandong University, Jinan 250061, People's Republic of - - 2014
This study aims to assess the prefrontal functional connectivity in elderly subjects with hypertension during the resting state using wavelet coherence analysis of changes in prefrontal tissue oxyhaemoglobin concentrations (Δ[HbO2]) signals measured by near-infrared spectroscopy (NIRS). Continuous recordings of NIRS signals were obtained from the left and right prefrontal lobes ...
Madhavan Kiely M KM Departments of Psychology University of Cincinnati Cincinnati, OH, USA; QLI Omaha, NE USA. Electronic address: - - 2014
Structural deterioration of brain tissue in older adults is thought to be responsible for the majority of age-related cognitive decline. Disruption of widespread cortical networks due to a loss of axonal integrity may also play an important role. Research examining correlations between structural change and functional decline has focused heavily ...
Ghisletta Paolo - - 2014
The brain-derived neurotrophic factor (BDNF) promotes activity-dependent synaptic plasticity, and contributes to learning and memory. We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. A total of 376 participants of the ...
Wang Shanshan S Department of Radiology, The First Hospital, China Medical University, #155, Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China. Electronic address: - - 2014
To investigate the microstructural integrity of superior cerebellar peduncles (SCP) and middle cerebellar peduncles (MCP) by using DTI tractography method, and further to detect whether the microstructural integrity of these major cerebellar pathways is related to motor function in children with diffuse periventricular leucomalacia (PVL) born preterm. 46 children with ...
Soo Cheryl C Australian Centre for Child Neuropsychology Studies, Murdoch Children's Research Institute, Royal Children's Hospital , Melbourne , Australia - - 2014
Abstract Background: A large literature documents psychosocial difficulties affecting participation in everyday activities following acquired brain injury (ABI). This study examined executive, behavioural and emotional contributions to psychosocial outcome in children with ABI. Method: Participants with ABI (n = 35; aged 7-18 years) were recruited from a rehabilitation department. Psychosocial functioning was ...
Kauffman Alexander A Department of Reproductive Medicine, University of California, San Diego, LA Jolla, CA, - - 2014
Age-related LH surge dysfunction in middle-aged rats is characterized, in part, by reduced responsiveness to estradiol (E2) positive feedback and reduced hypothalamic kisspeptin neurotransmission. Vasoactive intestinal peptide (VIP) neurons in the suprachiasmatic nucleus (SCN) project to hypothalamic regions that house kisspeptin neurons. Additionally, middle-age females express less VIP mRNA in ...
Gabard-Durnam Laurel J LJ University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095. Electronic address: - - 2014
Functional connections (FC) between the amygdala and cortical and subcortical regions underlie a range of affective and cognitive processes. Despite the central role amygdala networks have in these functions, the normative developmental emergence of FC between the amygdala and the rest of the brain is still largely undefined. This study ...
Hunsaker Michael R MR Department of Psychiatry and Behavioral Sciences, U C Davis Medical Center; The MIND Institute, U C Davis Medical - - 2014
Nonhuman primates are widely used models to investigate the neural substrates of human behavior, including the development of higher cognitive and affective function. Due to their neuroanatomical and behavioral homologies with humans, the rhesus macaque monkey (Macaca mulatta) provides an excellent animal model in which to characterize the maturation of ...
Holtrop Joseph L JL Department of Bioengineering Department, University of Illinois at Urbana-Champaign; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign. Electronic address: - - 2014
Changes in fine motor control that eventually compromise dexterity accompany advanced age; however there is evidence that age-related decline in motor control may not be uniform across effectors. Particularly, the role of central mechanisms in effector-specific decline has not been examined but is relevant for placing age-related motor declines into ...
Sarkar Subhendra N SN Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, - - 2014
MRI appearance of subthalamic nucleus (STN) boundaries in Parkinson's patients is often unreliable and not well understood. An objective comparison between FSE T2 and inversion recovery (FSTIR) sequences for stereotactic placement of deep brain stimulators is presented to advance current understanding of STN tissue contrast for refractory Parkinson's disease (PD). ...
Lu Tao T Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, - - 2014
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are unknown. Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in ...
Carter A B AB Centre for Sustainable Tropical Fisheries and Aquaculture and School of Earth and Environmental Sciences, James Cook University, Townsville, Qld 4811, Australia; School of Marine and Tropical Biology, James Cook University and ARC Centre of Excellence for Coral Reef Studies, Townsville, Qld 4811, - - 2014
The effects of size and age on reproductive dynamics of common coral trout Plectropomus leopardus populations were compared between coral reefs open or closed (no-take marine reserves) to fishing and among four geographic regions of the Great Barrier Reef (GBR), Australia. The specific reproductive metrics investigated were the sex ratio, ...
Carlyle Becky C BC Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT - - 2014
The pattern of neurodegeneration in Alzheimer's disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. In contrast, primary sensory cortices have few NFTs, even in late-stage disease. Understanding this ...
Battistella Giovanni G Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), and University of Lausanne, Lausanne, - - 2014
The dose-dependent toxicity of the main psychoactive component of cannabis in brain regions rich with cannabinoid CB1 receptors is well known in animal studies. However, research in humans does not show common findings across studies regarding the brain regions that are affected after long-term exposure to cannabis. In the present ...
Abutalebi Jubin J Department of Speech and Hearing Sciences, University of Hong Kong, Hong Kong, China; Centre of Cognitive Neurosciences, Department of Clinical Neurosciences, San Raffaele Scientific Institute, San Raffaele University, Milano, Italy. Electronic address: - - 2014
Cerebral gray-matter volume (GMV) decreases in normal aging but the extent of the decrease may be experience-dependent. Bilingualism may be one protective factor and in this article we examine its potential protective effect on GMV in a region that shows strong age-related decreases-the left anterior temporal pole. This region is ...
Van Horn John Darrell JD The Institute for Neuroimaging and Informatics (INI) and Laboratory of Neuro Imaging (LONI), Keck School of Medicine of USC, University of Southern California, 2001 North Soto Street - Room 102, Los Angeles, CA, 90032, USA, - - 2014
Neuroimaging, genetics, and phenomic explorations in the study of brain aging seek to characterize typical patterns of morphometric, function, and connectomics and how these change over the lifespan. With a detailed but multifaceted knowledge of these patterns, neuroscientists and clinicians can better recognize the processes at play when age-related brain ...
Mora M M Department of Endocrinology and Nutrition, Hospital Clínic I Universitari of Barcelona, Barcelona, - - 2014
Cognitive state and brain volume have been related to body mass index, abdominal fat, waist-hip ratio, components of metabolic syndrome (MS) and ghrelin. Genetic variations within the ghrelin gene have been recently associated to MS. The aim of our study was to investigate cognitive state by Mini-Mental State Examination (MMSE) ...
Yates Paul A PA From the Department of Nuclear Medicine and Centre for PET (P.A.Y., V.L.V., C.C.R.), Austin Health, Heidelberg; The University of Melbourne (P.A.Y., P.M.D., C.S., C.C.R.), Parkville; Department of Radiology (P.M.D., P.M.P., C.S.), Royal Melbourne Hospital, Parkville; National Ageing Research Institute (D.A.), Parkville; CSIRO Preventative Health Flagship (O.S.), Parkville; Florey Institute of Neuroscience and Mental Health (K.A.E., C.L.M., V.L.V.), The University of Melbourne, Parkville; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, Kew, Victoria; Centre of Excellence for Alzheimer's Disease Research and Care (R.N.M.), School of Exercise, Biomedical and Health Sciences, Edith Cowan University, - - 2014
We sought to determine the incidence and associations of lobar microbleeds (LMBs) in a longitudinal cohort with (11)C-Pittsburgh compound B (PiB) PET imaging. One hundred seventy-four participants from the observational Australian Imaging, Biomarkers and Lifestyle Study of Ageing (97 with normal cognition [NC], 37 with mild cognitive impairment [MCI], and ...
Jankowski K S KS University of Warsaw, Faculty of Psychology, Stawki 5/7, 00-183 Warsaw, Poland. Electronic address: - - 2014
The present study aimed at testing psychometric properties of the Composite Scale of Morningness (CSM) and validating it with mid sleep on free days (MSF) derived from the Munich ChronoType Questionnaire (MCTQ) in Poland, along with analyzing age and sex differences in the CSM and MSF. A sample of 952 ...
Wong Angelita Pui-Yee AP Department of Psychology, University of Toronto, Toronto, Canada; Rotman Research Institute, Baycrest, Toronto, - - 2014
The pituitary gland is a key structure in the hypothalamic-pituitary-gonadal (HPG) axis - it plays an important role in sexual maturation during puberty. Despite its small size, its volume can be quantified using magnetic resonance imaging (MRI). Here, we study a cohort of 962 typically developing adolescents from the Saguenay ...
Knopman David S DS Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA; Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: - - 2014
Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. We studied 806 cognitively ...
López de Abechuco E E AZTI-Tecnalia, Marine Research Division, Txatxarramendi Ugartea z/g, 48395 Sukarrieta, Bizkaia, - - 2014
Telomerase is a reverse transcriptase ribonucleoprotein that maintains the ends of linear chromosomes. This enzyme plays a major role in cell processes like proliferation, differentiation and tumorigenesis, being associated with aging and survival of species. In this study, the gene coding for TERT (telomerase reverse transcriptase) of two commercial fish ...
Scheinin Noora M NM Turku PET Centre, University of Turku and Turku University Hospital, - - 2014
Background/Objective: Our aim was to elucidate factors that contribute to amyloid-β (Aβ) accumulation in the brains of the seemingly healthy elderly population, and whether there is interplay between those factors. Methods: We conducted a cross-sectional positron emission tomography (PET) study with the amyloid tracer 11C-PIB, in 64 cognitively healthy subjects ...
Kim Jae-Min JM Department of Psychiatry, Chonnam National University Medical School, Gwangju, - - 2014
Brain-derived neurotrophic factor (BDNF) has been considered a risk factor for suicidal behavior in adult populations. BDNF secretion is influenced by epigenetic (DNA promoter methylation) and genetic (val66met polymorphism) profiles. We investigated the independent and interactive effects of BDNF methylation status and val66met polymorphisms on late-life suicidal ideation. In total, ...
Morales Angelica M AM 1] Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, USA [2] Psychiatry and Biobehavioral Sciences, Los Angeles, Los Angeles, California, USA [3] Brain Research Institute, University of California, Los Angeles, Los Angeles, California, - - 2014
The age period spanning late adolescence to emergent adulthood is associated with the highest prevalence of cigarette smoking in the United States, and is also a time of continued brain development. Nonetheless, while prior research has shown group differences in brain structure associated with smoking status in adults, few studies ...
Yi Ran R Department of Endocrinology and Metabolism, The First Affiliated Hospital of Harbin Medical University, Harbin, PR - - 2014
Alzheimer's disease (AD) is known as a leading cause of dementia in elderly persons. It is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction. AD can disrupt functional connectivity in distributed cortical networks. The S-estimator, which is a measure of multivariate intraregional synchronization, was analyzed in this study. Twenty ...
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