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Tilles Gérard G Bibliothèque Henri-Feulard, Hôpital Saint-Louis, Paris, - - 2014
From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as ...
Wang Mingyi M Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, Md., - - 2014
Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. ...
Lövdén Martin M Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany. Electronic address: - - 2014
The integrity of the brain's white matter is important for neural processing and displays age-related differences, but the contribution of changes in white matter to cognitive aging is unclear. We used latent change modeling to investigate this issue in a sample of very old adults (aged 81-103 years) assessed twice ...
Ramos Patrícia P REQUIMTE, Department of Chemical Sciences, Laboratory of Applied Chemistry, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, - - 2014
Using inductively coupled plasma-mass spectrometry after samples microwave-assisted acid digestion, zinc (Zn), copper (Cu), and manganese (Mn) levels were measured in 14 different areas of the human brain of adult individuals (n = 42; 71 ± 12, range 50-101 years old) without a known history of neurodegenerative, neurological, or psychiatric disorder. The main goals of ...
Banks William A WA Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington. Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle. - - 2014
Aging and obesity exert important effects on disease. Differentiating these effects is difficult, however, because weight gain often accompanies aging. Here, we used a nested design of aged, calorically restricted, and refed rats to measure changes in brain and blood levels of cytokines and gastrointestinal hormones, brain amyloid precursor protein ...
Thurman David J DJ Emory University School of Medicine, Department of Neurology, Decatur, GA, USA - - 2014
This report reviews recent research on the epidemiology of traumatic brain injuries among children and youth aged 0 to 20 years. Studies representing populations in North America, Europe, Australia, and New Zealand yield these median estimates of the annual incidence of childhood brain injuries: 691 per 100 000 population treated ...
Zhu Zude Z Department of Anatomy and Neurobiology. Electronic address: - - 2014
Age-related increases in right frontal cortex activation are a common finding in the neuroimaging literature. However, neurocognitive factors contributing to right frontal over-recruitment remain poorly understood. Here we investigated the influence of age-related reaction time (RT) slowing and white matter (WM) microstructure reductions as potential explanatory factors for age-related increases ...
Hanlon Colleen A CA Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC, - - 2014
Although established adult smokers with long histories of nicotine dependence have lower neural tissue volume than non-smokers, it is not clear if lower regional brain volume is also observed in younger, less established smokers. The primary goal of this study was to investigate neural tissue volume in a large group ...
Shen Yao Y Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, - - 2014
Astrocytes play multiple roles in physiological and pathological conditions in brain. However, little is known about the alterations of astrocytes in age-related changes, and few aging models of the astrocytes in vitro have been established. Therefore, in the present study, we used d-galactose (D-Gal) to establish astrocytes aging model to ...
Deoni S C L SC Advanced Baby Imaging Laboratory,School of Engineering, Brown University,Providence, - - 2014
Increasing evidence suggests that autism is associated with abnormal white-matter (WM) anatomy and impaired brain 'connectivity'. While myelin plays a critical role in synchronized brain communication, its aetiological role in autistic symptoms has only been indirectly addressed by WM volumetric, relaxometry and diffusion tensor imaging studies. A potentially more specific ...
Chen Jiu J Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu, P.R. - - 2014
The apolipoprotein E (APOE) gene has been confirmed as the major genetic risk factor for the conversion of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). The present study was to assess whether there was a specific interaction of APOE by the aging process on brain morphology in aMCI. ...
Josephs Keith A KA 1 Department of Neurology (Behavioural Neurology), Mayo Clinic, Rochester, MN 55905, USA 2 Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN 55905, USA - - 2014
Primary progressive apraxia of speech is a recently described neurodegenerative disorder in which patients present with an isolated apraxia of speech and show focal degeneration of superior premotor cortex. Little is known about how these individuals progress over time, making it difficult to provide prognostic estimates. Thirteen subjects with primary ...
Han Qingyu Q Key Laboratory of High Efficiency and Clean Mechanical Manufacture, School of Mechanical Engineering, Shandong University, Jinan, 250061 P.R. - - 2014
This study aims to assess the prefrontal functional connectivity using wavelet coherence analysis of cerebral tissue oxyhaemoglobin concentrations (Delta [HbO2]) signals in elderly subjects with cerebral infarction (CI) during the resting state. Continuous recordings of near-infrared spectroscopy (NIRS) signals were obtained from the left and right prefrontal lobes in 10 ...
Mather Karen A KA Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales, Sydney, - - 2014
As the population is ageing, a better understanding of the underlying causes of age-related cognitive decline (cognitive ageing) is required. Epigenetic dysregulation is proposed as one of the underlying mechanisms for cognitive ageing. We review the current knowledge on epigenetics and cognitive ageing and appraise the potential of epigenetic preventative ...
Xu Liming L Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. - - 2014
An interfacial lattice Ag(+) doped on TiO2 (Ag(+)/TiO2) was prepared by eluting Ag(0) clusters from a hydrothermally prepared Ag(0)/Ag(+)/TiO2 composite. An Ag(+)/TiO2@Ag(0) composite photocatalyst was subsequently obtained via a secondary Ag(0) clusters loading process to the Ag(+)/TiO2. The photocatalytic activity of Ag(+)/TiO2@Ag(0) was greatly improved compared to Ag(0)/Ag(+)/TiO2 and Ag(+)/TiO2. ...
King Kevin S KS Department of Radiology, University of Texas Southwestern Medical Center, - - 2014
Telomere length has been associated with dementia and psychological stress, but its relationship with human brain size is unknown. To determine if peripheral blood telomere length is associated with brain volume. Peripheral blood leukocyte telomere length and brain volumes were measured for 1960 individuals in the Dallas Heart Study, a ...
Pedersen Asger R AR Aarhus University, Hammel, Denmark - - 2014
Background. The impact of age on rehabilitation outcome after traumatic brain injury (TBI) as measured by changes in the Functional Independence Measure (FIM) has been addressed in several seemingly conflicting reports. Differences may be explained by different study populations and different ways of analyzing data. Objective. To investigate the role ...
Madden David J DJ Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710 USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 USA. Electronic address: - - 2014
Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature search task, detection of a shape singleton. On half of the trials, a salient distractor (a color singleton) was present ...
Shivakumar Venkataram V The Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India; Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India. Electronic address: - - 2014
The etiopathogenesis of schizophrenia is poorly understood. Within the proposed "neurodegeneration paradigm", observations have been put forth for "accelerated aging" in this disorder. This proposition is largely based on the neuroscience research that demonstrates progressive changes in brain as well as other systemic abnormalities supportive of faster aging process in ...
Serulle Yafell Y Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, New York, NY, 10016, USA, - - 2014
Evidence suggests that normal pressure hydrocephalus (NPH) is underdiagnosed in day to day radiologic practice, and differentiating NPH from cerebral atrophy due to other neurodegenerative diseases and normal aging remains a challenge. To better characterize NPH, we test the hypothesis that a prediction model based on automated MRI brain tissue ...
Phillmore Leslie S LS Departments of Psychology and Neuroscience, Dalhousie University, PO Box 15000, Halifax, Nova Scotia, Canada, B3R - - 2014
Plasticity in behavior is mirrored by corresponding plasticity in the brain in many songbird species. In some species, song system nuclei (Phillmore et al., 2006) are larger in birds in breeding condition than birds in non-breeding condition, possibly due to increased vocal output in spring. FoxP2, a transcription factor associated ...
Han Rui R Department of Radiology, Wuhan Integrated Traditional Chinese Medicine and Western Medicine Hospital, Wuhan, - - 2014
Objectives: This study was designed to investigate the feasibility of apparent diffusion coefficient (ADC) values in evaluating normal fetal brain development from gestational week 24 up to term age. Methods: Diffusion-weighted imaging (DWI) was performed on 40 normal fetuses (with normal results on sonography and normal fetal MRI results), with ...
Cherry Brandon H BH Department of Integrative Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA, - - 2014
Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments ...
Kumari Anita A Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, - - 2014
Nogo-A, a myelin-associated neurite growth inhibitory protein, is implicated in synaptic plasticity. It binds to its receptor namely the Nogo-66 receptor1 (NgR1) and regulates filamentous (F) actin dynamics via small GTPases of the Rho family, RhoA kinase (ROCK), LimK and cofilin. These proteins are associated with the structural plasticity, one ...
Kuan Ai-Seon AS Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, - - 2014
Head injury has been suggested to correlate with meningioma. However, results of studies investigating the relationship between head injury and meningioma were inconsistent. Therefore, we conducted this study to assess the association between head injury and meningioma, and to determine the possible risk factors. Head injury patients aged 18 years ...
Andrade de Oliveira Ailton A Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, - - 2014
Background: Neuroimaging techniques combined with computational neuroanatomy have been playing a role in the investigation of healthy aging and Alzheimer's disease (AD). The definition of normative rules for brain features is a crucial step to establish typical and atypical aging trajectories. Objective: To introduce an unsupervised pattern recognition method; to ...
Seifan Alon A Department of Neurology, Columbia University, New York, NY, USA Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, - - 2014
Background: Cerebral deposition of phospho-tau in Alzheimer's disease (AD) occurs with varying patterns within hippocampus. Lamina-specific tau changes in AD may reflect trans-synaptic propagation of phospho-tau along neuroanatomical pathways. Objective: To study patterns of tau deposition within inner (IML) and outer (OML) molecular layers of dentate gyrus and their clinical ...
Halfmann Kameko - - 2014
Objective: The neural systems most susceptible to age-related decline mirror the systems linked to decision making. Yet, the neural processes underlying decision-making disparities among older adults are not well understood. We sought to identify neural response patterns that distinguish 2 groups of older adults who exhibit divergent decision-making patterns. Method: ...
Yu Vickie Y - - 2014
It is well supported by behavioral and neuroimaging studies that typical language function is lateralized to the left hemisphere in the adult brain and this laterality is less well defined in children. The behavioral literature suggests there maybe be sex differences in language development, but this has not been examined ...
Papenberg Goran G Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden, - - 2014
Genetic factors may partly account for between-person differences in brain integrity in old age. Evidence from human and animal studies suggests that the dopaminergic system is implicated in the modulation of white-matter integrity. We investigated whether a genetic variation in the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism, which influences dopamine availability in ...
Harrison-Felix Cynthia L CL Craig Hospital, Research, Englewood, Colorado, United States ; - - 2014
This study characterized life expectancy after traumatic brain injury (TBI). The TBI Model Systems (TBIMS) National Database (NDB) was weighted to represent those 16 years of age and older completing inpatient rehabilitation for TBI in the United States (US) between 2001 and 2010. Analyses included Standardized Mortality Ratios (SMRs), Cox ...
Ambrose Charles T CT Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, - - 2014
Alzheimer's disease (AD) and related senile dementias (SDs) represent a growing medical and economic crisis in this country. Apart from cautioning persons about risk factors, no practical, effective therapy is currently available. Much of the recent research in AD has been based on the amyloid cascade theory. Another approach assumes ...
Failla Michelle D MD Department of Physical Medicine & Rehabilitation, University of Pittsburgh, School of Medicine, Pittsburgh PA Center for Neuroscience, University of Pittsburgh, Pittsburgh, - - 2014
Background. Mortality predictions following traumatic brain injury (TBI), and our understanding of TBI pathology, may be improved by including genetic risk in addition to traditional prognostic variables. One promising target is the gene coding for brain-derived neurotrophic factor (BDNF), a ubiquitous neurotrophin important for neuronal survival and neurogenesis. Objective. We ...
Vitaro Frank F University of Montreal, Montreal, QC, Canada, - - 2014
This study examined sibling influence over gambling involvement and delinquency in a sample of 628 twins (151 male dyads, 163 female dyads). Self-reports of gambling involvement and delinquency were collected for each twin at ages 13, 14 and 15 years. Results revealed evidence of between-twin influence. Higher levels of an adolescent's ...
Burke Sara N SN Evelyn F. McKnight Brain Institute, ARL Division of Neural Systems, Memory & - - 2014
The orbitofrontal cortex (OFC) and amygdala are both necessary for decisions based on expected outcomes. Although behavioral and imaging data suggest that these brain regions are affected by advanced age, the extent to which aging alters appetitive processes coordinated by the OFC and the amygdala is unknown. In the current ...
Moran Chris C Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Victoria, AustraliaNeurosciences, Monash Medical Centre, Monash Health, Melbourne, - - 2014
Type 2 Diabetes Mellitus (T2DM) is associated with brain atrophy, but the mechanisms underlying this link are unknown. Advanced glycation end products (AGEs) accumulate in T2DM resulting in inflammation, oxidative stress, and protein cross-linking, which are known contributors to neurodegeneration. We aimed to study whether tissue AGE accumulation is associated ...
Burke Luke K LK Department of Pharmacology, University of Cambridge, Cambridge, - - 2014
The phenomenon commonly described as "the middle-age spread" is the result of elevated adiposity accumulation throughout adulthood until late middle-age. It is a clinical imperative to gain a greater understanding of the underpinnings of age-dependent obesity and in turn, how these mechanisms may impact the efficacy of obesity treatments. In ...
Peskind Elaine R ER Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle2Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, - - 2014
The Healthy Brain Initiative 2013-2018 seeks to optimize brain health as we age. Free radical injury is an important effector of molecular and cellular stress in the aging brain that derives from multiple sources. To identify potentially modifiable risk factors associated with increased markers of brain oxidative stress. This cross-sectional, ...
Chang Vicky C VC Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, - - 2014
To provide an overview of the epidemiology of work-related traumatic brain injury (wrTBI) in the state of Victoria, Australia. Specifically, we investigated sex differences in incidence, demographics, injury characteristics, in addition to outcomes associated with wrTBI. This study involved secondary analysis of administrative workers' compensation claims data obtained from the ...
Scharfman Helen E HE Departments of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry, New York University Langone Medical Center, New York, NY 10016. Electronic address: - - 2014
When all of the epilepsies are considered, sex differences are not always clear, despite the fact that many sex differences are known in the normal brain. Sex differences in epilepsy in laboratory animals are also unclear, although robust effects of sex on seizures have been reported, and numerous effects of ...
Vegh Marlene J MJ VU University Amsterdam, - - 2014
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive function observed during healthy brain aging is most likely caused by changes in brain connectivity and synaptic dysfunction in particular brain regions. Here we show that aged C57BL/6J wildtype mice have hippocampus-dependent spatial memory impairments. To ...
Harris Kelly C - - 2014
Abstract Background: The N1-P2 is an obligatory cortical response that can reflect the representation of spectral and temporal characteristics of an auditory stimulus. Traditionally, mean amplitudes and latencies of the prominent peaks in the averaged response are compared across experimental conditions. Analyses of the peaks in the averaged response only ...
Laing Andrew C AC Injury Biomechanics and Aging Laboratory, Department of Kinesiology, University of Waterloo, 200 University Ave West, Waterloo, Ontario, N2L 3G1, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, 818 West 10th Avenue, Vancouver, British Columbia, V5Z 1M9, - - 2014
Rat models are commonly used to investigate the pathophysiological pathways and treatment outcomes after spinal cord injury (SCI). The high incidence of fall-induced SCI in older adults has created a need for aging models of SCI in rats to investigate potential age-related differences in SCI severity and outcomes. The aims ...
Sato João Ricardo JR Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo Andre, Brazil; Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil. Electronic address: - - 2014
The investigation of neurodevelopment during late childhood and pre-adolescence has recently attracted a great deal of interest in the field of neuroimaging. One promising topic in this field is the formation of brain networks in healthy subjects. The integration between neural modules characterizes the ability of the network to process ...
Roy Maggie M CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France; Research Center on Aging, Université de Sherbrooke, Sherbrooke, Quebec, - - 2014
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks, and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal ...
Painter Michio W MW F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Immunology Program, Harvard Medical School, Boston, MA 02115, - - 2014
The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of functional recovery after nerve injury compared to 2-month-old animals. We find no difference in the intrinsic growth capacity between aged and young sensory neurons ...
Chang Kwang-Hwa KH Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan - - 2014
Abstract Purpose: To explore the association between muscle power impairment and each World Health Organization Disability Assessment Schedule second edition (WHODAS 2.0) domain score among subjects with physical disability. Methods: Subjects (≥60 years) with physical disability related to neurological diseases, including 730 subjects with brain disease (BD) and 126 subjects ...
Galea Liisa A M LA Department of Psychology, The University of British Columbia, Vancouver, BC, - - 2014
The peripartum period is accompanied by dramatic changes in hormones and a host of new behaviors in response to experience with offspring. Both maternal experience and maternal hormones can have a significant impact on the brain and behavior. This review outlines recent studies demonstrating modifications in hippocampal plasticity across the ...
Sakurai Ryota R - - 2014
The objective of this study was to investigate the relationship between normalized regional cerebral metabolic rates of glucose (normalized-rCMRglc) and gait function in physically and mentally high-functioning older women. One hundred eighty-two community-dwelling older women (mean age [SD], 69.4 [6.6] years) without disability in instrumental activities of daily living and ...
Gaur Pankaj P Biochemistry and Molecular Biology Lab, CAS in Zoology, Banaras Hindu, University, Varanasi, 221005, UP, - - 2014
Fragile X mental retardation protein (FMRP) has been implicated in learning, memory and cognition, therefore, information on alterations in FMRP expression during maturation and aging may provide a clue towards understanding mechanisms of age-dependent cognitive changes in the brain. In the present paper, we have studied Fmr-1 gene expression and ...
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