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Dhahbi Joseph M JM Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA; Center for Genetics, Childrens Hospital Oakland Research Institute, Oakland, CA 94609, USA. Electronic address: - - 2014
Small noncoding RNAs (sncRNAs) mediate a variety of cellular functions in animals and plants. Deep sequencing has made it possible to obtain highly detailed information on the types and abundance of sncRNAs in biological specimens, leading to the discovery that sncRNAs circulate in the blood of humans and mammals. The ...
Gupta Shashi Kumar SK Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, - - 2014
The increasing burden of ageing populations and their healthcare expenditure is a major challenge worldwide. Ageing is a complex disorder and can be defined as progressive decline in function with time leading to increased incidence of various cardiovascular, neurological and immunological diseases. The human genome comprises of many protein coding ...
Abe Masashi M Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2014
MicroRNAs (miRNAs) are 20- to ∼24-nucleotide (nt) small RNAs that impact a variety of biological processes, from development to age-associated events. To study the role of miRNAs in aging, studies have profiled the levels of miRNAs with time. However, evidence suggests that miRNAs show heterogeneity in length and sequence in ...
Mu Ying Y College of Life Sciences and Biotechnology, Beijing Forestry University, Mail-box 162#, No. 35 Qinghua East Road, Haidian District Beijing, 100083 People's Republic of China ; National Engineering Laboratory for Tree Breeding, Beijing, 100083 People's Republic of China ; Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, Beijing, 100083 People's Republic of China ; The Tree and Ornamental Plant Breeding and Biotechnology Laboratory of State Forestry Administration, Beijing, 100083 People's Republic of - - 2014
Telomeres and telomerase have important biological functions and can protect chromosome ends. In this study, sex- and season-dependent changes in telomere length and telomerase activity in ash and willow were analyzed. A statistical analysis showed that the telomere lengths of male and female trees differed significantly (P < 0.05). In ash, the ...
Petersen Johannes J Department of Radiology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, - - 2013
Chronic apical periodontitis (CAP) appears to be a risk factor for coronary heart disease. The aims of the study were to estimate the significance of AP for the atherosclerotic burden and to examine the potential effect of endodontic treatment. The whole-body computed tomography (CT) examinations of 531 patients with a ...
Gendron Christi M CM Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, - - 2014
Sensory perception can modulate aging and physiology across taxa. We found that perception of female sexual pheromones through a specific gustatory receptor expressed in a subset of foreleg neurons in male fruit flies, Drosophila melanogaster, rapidly and reversibly decreases fat stores, reduces resistance to starvation, and limits life span. Neurons ...
Zmora Nilli - - 2013
The crustacean male-specific androgenic hormone is widely accepted as a key factor in sexual differentiation and in the development of secondary sex characteristics. However, the mechanism by which the plethora of different reproductive strategies are controlled and executed in crustaceans is not known. We discovered in the blue crab, Callinectes ...
Cheng Guanghui - - 2013
Telomeres play an important role in the maintenance of genomic stability/integrity and are synthesized by the RNA-dependent polymerase telomerase. Progressive telomere shortening contributes to both in vitro and in vivo aging, and telomere length dynamics and telomerase expression profile in human tissues during extrauterine life have been well characterized. However, ...
Carvalho Ana - - 2013
The expression of the ribosomal RNA (rRNA) genes from rye, located within the nucleolus organizer regions (NORs), is repressed by cytosine methylation in wheat x rye hybrids and in triticale, as consequence of nucleolar dominance. Our previous study revealed that bread wheat cultivars with a maximum number of four Ag-NORs ...
Lok Judith J - - 2013
To assess whether CD8 T-cell activation predicts risk of AIDS and non-AIDS morbidity during suppressive antiretroviral treatment (ART). Posthoc analyses of ART-naive participants in prospective ART studies. Participants with HIV-RNA levels 200 copies/ml or less and CD8 T-cell activation data (%CD38HLA-DR) at year-1 of ART were selected to determine years 2-5 ...
Grant Philip M - - 2013
Background. Bone mineral density (BMD) decreases 2-6% in the two years after antiretroviral therapy (ART) initiation. Pre-ART immune deficiency and early immune recovery may contribute to this loss. Methods. We pooled data from three treatment-naive ART initiation studies in which serial whole-body dual-energy X-ray absorptiometry scans were performed. We used linear regression ...
Takahashi Kensuke - - 2013
Lower respiratory tract infection (LRTI) including Community-acquired pneumonia (CAP) is a common infectious disease that is associated with significant morbidity and mortality. The patterns of aetiological pathogens differ by region and country. Special attention must be paid to CAP in Southeast Asia (SEA), a region facing rapid demographic transition. Estimates ...
Tudela Rebeca - - 2013
In this study the catabolites derived from RNA degradation were assessed in Cava sparkling wines as a consequence of lees autolysis. For this purpose, the changes in the content of adenosine, guanosine, inosine, uridine, hypoxanthine, xanthine, and uric acid were determined by UHPLC-MS/MS, in sparkling wines produced on industrial scale, ...
Holmes Andrew P - - 2013
RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events. Previous studies have suggested a link between gene-specific reductions in adenosine to inosine RNA editing and aging ...
Sato Reiko - - 2013
BACKGROUND: Community-acquired pneumonia (CAP) causes substantial clinical and economic burden. While several studies have reported the cost to treat CAP, there is little information on the cost to treat by age, risk profile, and hospitalization in US adults aged ≥50 years. OBJECTIVE: To quantify the cost, from a payer perspective, of ...
Wyrwich Kathleen W - - 2013
PURPOSE: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality in older adults, yet few studies have comprehensively measured the burden of CAP symptoms and their impact from the patient perspective. Our Web-survey used the newly developed CAP burden of illness questionnaire (CAP-BIQ) designed to assess the presence ...
Jorgensen Anders - - 2013
Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We ...
Justice Amy C AC Department of Internal Medicine, Yale University and the Veterans Affairs Healthcare System, West Haven, CT 06516, USA. - - 2013
By supplementing an index composed of HIV biomarkers and age (restricted index) with measures of organ injury, the Veterans Aging Cohort Study (VACS) index more completely reflects risk of mortality. We compare the accuracy of the VACS and restricted indices (1) among subjects outside the Veterans Affairs Healthcare System, (2) ...
Gessner Bradford D - - 2012
We evaluated pneumococcal serotype/group distribution using polymerase chain reaction (PCR) testing on cerebrospinal fluid collected from patients from Burkina Faso and Togo who presented for care during 2007-2009. We identified 282 pneumococcal meningitis cases based on PCR, latex agglutination, or culture, of which 206 underwent serotyping. Serotype 1 was identified ...
Rieux Anais - - 2012
A longitudinal study was undertaken to characterize the course of Cryptosporidium infection in a dairy goat farm located in western France. Two cohorts of twenty-five and fifteen animals, respectively, were sampled once a week from birth to weaning. Each individual fecal sample was screened using direct immunofluorescence (IFT) and if ...
Qi Baiyu - - 2013
Bloodstain age is a parameter that can be used in crime scene investigations. Bloodstain age can be determined by measuring the 18S rRNA:β-actin mRNA ratio by Reverse Transcription-quantitative PCR (RT-qPCR). Since this ratio is a function of time, it can be used as an estimator of bloodstain age. However, it ...
Li Han-Mei - - 2012
A novel anionic PEG derivative with a wheat-like structure, PEG-poly(AGE-Suc) was synthesized. The spikelet part of this polymer consisted of 9.3 pairs of carboxylic acid-side chains was conjugated at one end of the PEG chain. The neutral linear PEG1580 was designed as the stalk part to improve the biocompatibility of ...
Chang Anne Lynn S - - 2013
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and ...
Landau Susan M - - 2012
To assess the association between lifestyle practices (cognitive and physical activity) and β-amyloid deposition, measured with positron emission tomography using carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB), in healthy older individuals. Cross-sectional clinical study. Berkeley, California. Volunteer sample of 65 healthy older individuals (mean age, 76.1 years), 10 patients with Alzheimer ...
Forni Cristiana - - 2012
Knowledge about the long-term sequelae of rotationplasty, in adults treated surgically in childhood for Osteosarcoma in the lower limb, mainly concerns function and performance; the aim of this study is to explore the experience and the Quality of Life (QoL) of the patients who underwent Rotationplasty from 1986 to 2006 ...
Greenspan Robin L - - 2012
: The purpose of this study was to evaluate frequency, intensity, and associations of distal spinal cord F-18 FDG uptake visible on PET/CT. Normal cervical, but not distal cord uptake, has been reported previously. : This is a retrospective review of consecutive oncologic whole body PET/CTs from 14 June, 2006 ...
Alic Nazif - - 2012
RNA interference (RNAi) provides an important tool for gene function discovery. It has been widely exploited in Caenorhabditis elegans ageing research because it does not appear to have any non-specific effects on ageing-related traits in that model organism. We show here that ubiquitous, adult-onset activation of the RNAi machinery, achieved ...
Mangerich Aswin - - 2012
Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome maintenance and inflammation. The nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP1), which catalyzes the synthesis of the biopolymer poly(ADP-ribose), exhibits an essential role in both processes. On the one hand, PARP1 serves as a genomic ...
Dahlbom S Josefin - - 2011
Social defeat is a common model for studies on depression. However, such models are most often used to study aggression in males and sex differences in depression may therefore be overseen. This study investigated the potential of the zebrafish (Danio rerio) as a model for male and female aggression. In ...
Sperling Karl - - 2011
The objective of this study is to investigate the prevalence of Down syndrome (DS) associated with Chernobyl fallout. Maternal age-adjusted DS data and corresponding live birth data from the following seven European countries or regions were analyzed: Bavaria and West Berlin in Germany, Belarus, Hungary, the Lothian Region of Scotland, ...
Kranz Jasmin - - 2013
To analyse whether the permeability of the blood-brain barrier to the antimuscarinic drug trospium chloride is altered with ageing. This is a relevant question for elderly patients with overactive bladder syndrome who are treated with trospium chloride as the occurrence of adverse effects on the central nervous system (CNS) highly ...
Stoduto Gina - - 2011
BACKGROUND: Cocaine is one of the more commonly found illicit drugs in injured drivers. In this work, we examine the association between self-reported past year cocaine use and past year collision involvement in a large representative sample of adult drivers in Ontario. METHODS: Data are based on the CAMH Monitor, ...
Aragão Florbela da Rocha - - 2011
The aim of this study was to identify the effects of body composition and menopause characteristics on maximal oxygen uptake (V˙O2max) variation in postmenopausal women. The study was conducted on 208 healthy women aged 49 to 79 years. Data related to menopause were obtained through medical history. Measurements of fat ...
Bucerius Jan - - 2011
We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients. The atherosclerotic disease process is characterized by infiltration and retention of oxidized lipids in the artery wall, triggering a ...
Wong Ka Kit - - 2011
Gender differences in brain dopaminergic activity have been variably reported in the literature. We performed an evaluation for gender effects on striatal dopamine transporter (DAT) binding in a group of normal subjects. Community-dwelling adults (n=85, 50F/35M, mean age 62.7±16.2 SD, range 20-85) underwent DAT [(11)C]2-β-carbomethoxy-3β-(4-fluorophenyl) tropane (β-CFT) positron emission tomography ...
Patil Sumit T - - 2011
A total 375 Indian children of age 1 day to 19 years were studied (male 194 and female 181). For determining the bone age (skeletal age), wrist and hand radiographs were taken. The skeletal age was determined by blinded review of radiograph using Greulich and Pyle atlas (2nd edition, 1959). ...
Terry-McElrath Yvonne M YM Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48106-1248, USA. - - 2013
Young adults in the USA have one of the highest smoking prevalence rates of any age group, and young adulthood is a critical time period of targeting by the tobacco industry. The authors examined relationships between potential exposure to tobacco-related media campaigns from a variety of sponsors and 2-year smoking ...
Hill Kylie - - 2011
We sought to describe responses to the 6-min walk test (6MWT) in healthy Canadian adults in order to facilitate interpretation of its results in patient populations. Seventy-seven healthy Canadians aged 45 to 85 years (65 ± 11 years, 40 females) completed this study. During a single visit, three 6MWTs were undertaken. The main outcome ...
O'Connell-Rodwell Caitlin E - - 2011
Elephant/human conflict mitigation solutions have been explored with varying degrees of success. We present findings on a potential acoustic tool to reduce negative outcomes of male elephants entering agricultural areas in the region northeast of Etosha National Park, Namibia. We monitored elephant traffic within and outside the park boundary using ...
Eppinger Ben B Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany. - - 2011
In this paper, we review the current literature to highlight relations between age-associated declines in dopaminergic and serotonergic neuromodulation and adult age differences in adaptive goal-directed behavior. Specifically, we focus on evidence suggesting that deficits in neuromodulation contribute to older adults' behavioral disadvantages in learning and decision making. These deficits ...
Obara Yoshiaki - - 2011
Virgin female cabbage butterflies, Pieris rapae crucivora, accept and mate with courting males, whereas mated females reject them and assume the "mate refusal posture". This study tested whether the biogenic amines, serotonin (5HT), dopamine (DA), and octopamine (OA), were responsible for this change in behavior. The results showed that 2-3-day-old ...
Ansah Twum A - - 2011
It has been well established that aging is the most prominent risk factor for PD. In the MPTP mouse model which has been widely used to study PD, studies have shown that MPTP exhibits its neurotoxic effects on the dopaminergic system in an age-dependent manner. Although it is recognized the ...
Ehleringer James R - - 2011
Measurements were made on the natural abundance (14)C content (Δ(14)C) of cocaine specimens seized between 2003 and 2009. The objective of this study was to determine the extent to which Δ(14)C analyses could quantify the "age" of recent cocaine seizures. Here "age" of a seized cocaine specimen is defined as ...
Zenk Shannon N - - 2012
Global positioning systems (GPS) have emerged as a research tool to better understand environmental influences on physical activity. This study examined the feasibility of using GPS in terms of perceived acceptability, barriers, and ease of use in a racially/ethnically diverse sample of lower socioeconomic position (SEP). Data were from 2 ...
Coria Francisco - - 2011
BACKGROUND: Isolated action tremor (IAT) is the hallmark clinical feature of essential tremor (ET), but it may also be a prominent feature of some individuals with Parkinson's disease (PD) suggesting a pathogenic relationship between these two disorders. OBJECTIVES: We investigated the integrity of the striatal presynaptic dopaminergic system in subjects ...
Gaillat Jacques - - 2011
(See the Editorial Commentary by Crumpacker II on pages 411-412.) Background. The consequences of the epidemiology of varicella for zoster epidemiology are still debated. We therefore compared the frequency of herpes zoster in an adult population with virtually no varicella zoster virus (VZV) exposure with that in the general population (GP). ...
Kurugöl Zafer - - 2011
In order to assess immunity to rubella in Izmir, Turkey, a total of 600 persons of 1-70 years of age were selected with cluster sampling. Of the 597 subjects, 120(20.1%) was susceptible to the rubella according to their serum antibody levels. Of children 1 to 6 years of age, 50.9% ...
Obeid Rima - - 2011
Advanced glycation end products (AGEs) contribute to aging. Cobalamin (Cbl) is required for cell growth and functions, and its deficiency causes serious complications. Diabetics and renal patients show high concentrations of Cbl, but metabolic evidence of Cbl deficiency that is reversible after Cbl treatment. Cbl might be sequestered in blood ...
Stanley E M - - 2011
GABAergic neurons of the medial septum of the basal forebrain make up a substantial portion of the septo-hippocampal pathway fibers, and are known to modulate hippocampal amino acid neurotransmission and support cognitive function. Importantly, these neurons are also implicated in age-related cognitive decline. Hypothalamic orexin/hypocretin neurons innervate and modulate the ...
Pope Sandra K - - 2011
Little is known about the relationship of gender with cocaine use in rural areas. This study describes these relationships among stimulant users residing in rural areas of Arkansas, Kentucky, and Ohio. Understanding the characteristics of crack and powder cocaine users in rural areas may help inform prevention, education, and treatment ...
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