Search Results
Results 1 - 50 of 1694
1 2 3 4 5 6 7 8 9 10 >
Acevedo Cristian A CA Centro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso, Chile, - - 2014
Biomaterials based on crosslinked sponges of biopolymers have been extensively used as scaffolds to culture mammal cells. It is well known that single biopolymers show significant change over time due to a phenomenon called physical ageing. In this research, it was verified that scaffolds used for skin tissue engineering (based ...
Rajak S K SK Livestock Research Centre, National Dairy Research Institute, Karnal 132001, India - - 2014
Present study analyzed the changes in peripheral blood testosterone concentrations and testicular cytogram in relation to age and semen quality in crossbred males. Three different age groups of crossbred males viz. bull calves (6 months, n = 5), young bulls (15 months, n = 5) and adult bulls (4 to ...
Lin Yun - - 2014
Telomeres are essential in maintaining chromosome integrity and in controlling cellular replication. Attrition of telomere length in peripheral blood mononuclear cells (PBMCs) with age is well documented from cross-sectional studies. But the actual in vivo changes in telomere lengths and its relationship with the contributing factors within individuals with age ...
Ishigami Akihito A Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, - - 2014
Senescence marker protein-30 (SMP30)/gluconolactonase (GNL) is an age-associated protein in that its presence decreases with aging. Here, we used immunohistochemical analysis to investigate the changes of SMP30/GNL in individual cells of the liver from progressively aged mice. Male C57BL/6 strain mice at 1, 3, 6, 12, 24 and 30 months-of-age ...
Feng Xingmei X Department of stomatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province 226001, People's Republic of - - 2014
Mesenchymal stem cells derived from human dental pulp (DP-MSCs) are characterized by self-renewal and multi-lineage differentiation, which play important roles in regenerative medicine. Autologous transfers, as non-immunogenic, constitute the safest approach in cellular transplantations. However, their use may be limited by age-related changes. In the study, we compared DP-MSCs isolated ...
Chinta Shankar J SJ Buck Institute for Research on Aging, Novato, CA 94945, - - 2014
Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors ...
Ki Sanghee S Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, - - 2014
Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here, we present transcriptional profiling of purified thymic stromal subsets from mice 1, 3, and 6 months of age spanning early ...
Martin Nadine N Cell Proliferation Group, Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, - - 2014
The p16(INK4a) cell cycle regulator is one of the best ageing biomarkers because it is suppressed in early embryogenesis and progressively induced during ageing. p16(INK4a) plays a crucial role in key cell fate decisions which contribute to ageing, such as cellular senescence and stem cell dynamics. Detailed examination of the ...
Beerman Isabel I Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, MA 02116, USA. Electronic address: - - 2014
Aging is invariably associated with alterations of the hematopoietic stem cell (HSC) compartment, including loss of functional capacity, altered clonal composition, and changes in lineage contribution. Although accumulation of DNA damage occurs during HSC aging, it is unlikely such consistent aging phenotypes could be solely attributed to changes in DNA ...
Kumar Surender S Department of Inorganic and Physical Chemistry, Indian Institute of Science - 560012, India. - - 2014
Silver nanoparticles-anchored reduced graphene oxide (Ag-RGO) is prepared by simultaneous reduction of graphene oxide and Ag(+) ions in an aqueous medium by ethylene glycol as the reducing agent. Ag particles of average size of 4.7 nm were uniformly distributed on the RGO sheets. Oxygen reduction reaction (ORR) is studied on ...
Tian Xiao-Li XL Department of Human Population Genetics and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine (IMM), Peking University, Beijing 100871, China. Electronic address: - - 2014
Advanced age is an independent risk factor for ageing-related complex diseases, such as coronary artery disease, stroke, and hypertension, which are common but life threatening and related to the ageing-associated vascular dysfunction. On the other hand, patients with progeria syndromes suffer from serious atherosclerosis, suggesting that the impaired vascular functions ...
Jung Hwa Jin HJ Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 11363, - - 2014
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles ...
Chen R R From the Department of Diagnostic Radiology and Nuclear Medicine (R.C., J.K., E.H.H., E.R.M.), University of Maryland, Baltimore, Maryland; Department of Neurology (M.A.), Medical University of Silesia, Katowice, Poland; Department of Radiology (R.A.Z.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Department of Radiology (R.C., R.A.Z.), Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. - - 2014
Age-related changes in brain morphology are crucial to understanding the neurobiology of sickle cell disease. We hypothesized that the growth trajectories for total GM volume, total WM volume, and regional GM volumes are altered in children with sickle cell disease compared with controls. We analyzed T1-weighted images of the brains ...
Geiger Hartmut H Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA; Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany. Electronic address: - - 2014
Aging of stem cells might be the underlying cause of tissue aging in tissue that in the adult heavily rely on stem cell activity, like the blood forming system. Hematopoiesis, the generation of blood forming cells, is sustained by hematopoietic stem cells. In this review article, we introduce the canonical ...
Demirovic Dino D Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, - - 2014
Repeated exposure to mild heat shock (HS) has been shown to induce a wide range of health promoting hormetic effects in various biological systems, including human cells undergoing aging in vitro. In order to understand how cells distinguish between mild and severe stress, we have investigated the extent of early ...
Kuipers Sjoukje D SD Department of Biomedicine, University of Bergen, Bergen, - - 2014
Adult hippocampal neurogenesis drastically diminishes with age but the underlying mechanisms remain unclear. Here, age-related influences on the hippocampal early neuroprogenitor cell (NPC) pool was examined by quantifying changes in Sox1-expressing cells in the dentate gyrus subgranular zone from early adulthood (3 months) to middle age (12 months). Proliferation of distinct NPC ...
Zheng Ji J Department of Chemistry, Shantou University, Guangdong 515063, P. R. China. - - 2014
A series of Ag(i) coordination oligomers with Ag-Ag distances tuned by amine auxiliary ligands were designed and synthesized. Their dual emissions could be adjusted by changing either excitation energy or temperature. The emission assignments were clarified by both experimental and DFT evidence herein.
Squitti Rosanna R Dept. of Neuroscience, AFaR - Osp. Fatebenefratelli, Isola Tiberina, Rome, Italy; Laboratory of Neurodegeneration, IRCSS "San Raffaele Pisana", Rome, - - 2014
Objectives: Meta-analyses show that non-bound ceruloplasmin (Non-Cp) copper (also known as 'free' or labile copper) in serum is higher in patients with Alzheimer's disease (AD). It discriminates subjects with Mild Cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed in ...
Mathew Philips P Reader, Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital , Annamalai University, Chidambaram, Tamil Nadu, India - - 2014
Oral Squamous cell carcinoma (OSCC) is often preceded by potentially malignant disorders (PMDs) like oral submucous fibrosis (OSMF). The rate of transformation of OSMF to OSCC ranges from 3 to 19%. OSMF is etiologically related to chewing of areca nut (betel nut), a habit prevalent among the population groups in ...
Rodriguez Manuel M Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna La Laguna, Tenerife, Canary Islands, Spain ; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Madrid, - - 2014
Available data show marked similarities for the degeneration of dopamine cells in Parkinson's disease (PD) and aging. The etio-pathogenic agents involved are very similar in both cases, and include free radicals, different mitochondrial disturbances, alterations of the mitophagy and the ubiquitin-proteasome system. Proteins involved in PD such as α-synuclein, UCH-L1, ...
Herzog Fabian F Adolphe Merkle Institute, BioNanomaterials, University of Fribourg, Rte de l'Ancienne Papeterie, CP 209, 1723 Marly, - - 2014
In the emerging market of nano-sized products, silver nanoparticles (Ag NPs) are widely used due to their antimicrobial properties. Human interaction with Ag NPs can occur through the lung, skin, gastrointestinal tract, and bloodstream. However, the inhalation of Ag NP aerosols is a primary concern. To study the possible effects ...
Fukada So-Ichiro S Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University Osaka, - - 2014
Advances in medical science and technology allow people live longer lives, which results in age-related problems. Humans cannot avoid the various aged-related alterations of aging; in other words, humans cannot remain young at molecular and cellular levels. In 1956, Harman proposed the "free radical theory of aging" to explain the ...
Bennmann Dorit D Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Halle (Saale), - - 2014
Advanced glycation endproducts (AGEs) represent a non-enzymatic posttranslational protein modification. AGEs are generated by a series of chemical reactions of free reducing monosaccharides, such as glucose, fructose or metabolites of the monosaccharide metabolism with amino groups of proteins. After oxidation, dehydration and condensation, stable AGE-modifications are formed. AGE-modified proteins accumulate ...
Adeyemo Titilope T Department of Haematology and Blood transfusion, College of Medicine, University of Lagos, P.M.B 12003, Surulere, Lagos, - - 2014
Sickle cell disease (SCD) is the most common inherited disorder of haemoglobin worldwide. This study evaluated the chromatographic patterns and red blood cell indices of sickle cell patients to determine the co-inheritance of other haemoglobin(Hb) variants and β-thalassaemia trait. Red cell indices, blood film, sickle solubility test, Hb electrophoresis using ...
Duscher Dominik D Hagey Laboratory for Pediatric Regenerative Medicine; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, - - 2014
Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have previously been shown to play an important role in neovascularization and deficiencies in these cells have been described in aged patients. Here we utilize ...
Zhou Hui H Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, United States of America; Center for Translational Neuroscience, University of Missouri School of Medicine, Columbia, Missouri, United States of - - 2014
Aged garlic extract (AGE) is widely used as a dietary supplement, and is claimed to promote human health through anti-oxidant/anti-inflammatory activities with hypolipidemic, antiplatelet and neuroprotective effects. Prior studies of AGE have mainly focused on its organosulfur compounds, with little attention paid to its carbohydrate derivatives, such as N-α-(1-deoxy-D-fructos-1-yl)-L-arginine (FruArg). ...
Meyer Matthias R MR Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, United - - 2013
Aging, a physiological process and main risk factor for cardiovascular and renal diseases, is associated with endothelial cell dysfunction partly resulting from NADPH oxidase-dependent oxidative stress. Because increased formation of endothelium-derived endothelin-1 (ET-1) may contribute to vascular aging, we studied the role of NADPH oxidase function in age-dependent contractions to ...
Shi Long - - 2013
Delayed healing of corneal epithelial wounds is a serious complication in diabetes. Advanced glycation end products (AGEs) are intimately associated with the diabetic complications and are deleterious to the wound healing process. However, the effect of AGEs on corneal epithelial wound healing has not yet been evaluated. In the present ...
Kayaaltı Zeliha Z Institute of Forensic Sciences, Ankara University, No: 27, Dikimevi, 06590, Ankara, Turkey, - - 2013
Aging is a complex and multifactorial process that is stimulated by a number of factors including genes and life-style. It is thought that the production of reactive oxygen species (ROS) in the face of antioxidant enzymes and molecules is related to aging and age-related diseases. NAD(P)H oxidase system is the ...
Benato Livia - - 2013
Analysis of vitamins and trace elements has gained importance in avian medicine in recent years. It has become evident that interpretation should be based on species-specific reference intervals due to differences in intervals between species. This study was performed to evaluate the blood concentrations of vitamins A (retinol), B1 (thiamine), ...
Martuscelli M - - 2013
Aim of this research was to study the effect of some agronomic and oenological factors on the content of biogenic amines as quality index of sixty-five Abruzzo wines. Sum of amines was found to be decreasing in the order: red (19.3±12.8mgL(-1)), rosé (9.20±6.34mgL(-1)), white (7.67±3.84mgL(-1)) wine. Significant differences in relationship ...
Liu Samuel S - - 2013
Biogenic amines are known to play critical roles in key insect behaviors such as feeding and reproduction. This study documents the effects of reserpine on mating and egg-laying behaviors of the stable fly, Stomoxys calcitrans (L.) (Diptera: Muscidae), which is one of the most significant biting fly pests affecting cattle. ...
Joseph Michael F MF Kinesiology Dept, University of Connecticut, Storrs, CT, - - 2012
Achilles tendon rupture is often the result of a long-term degenerative process, frequently occurring asymptomatically. To determine the prevalence of asymptomatic Achilles tendinopathy in an active, asymptomatic, young-adult population and to compare these findings across gender. Convenience sample, cohort study. Research laboratory A sample of 52 (28 male, 24 female) ...
Ali A - - 2012
A 10-year-old, clinically healthy, male dromedary camel had presented a history of progressive unilateral testicular enlargement over the past 5 years. The animal had mated with 32 females during that period; all had conceived. The sex ratio of his offspring was one male to 31 females. Ultrasound examination of the right ...
Schramm Christoph - - 2012
Background:  It is often difficult to determine the correct size of endotracheal tubes (ETT) needed for intubating pediatric patients. Therefore, we evaluated the role of ultrasound in pediatric patients to compare the correct size of an uncuffed (ETT) with the minimal transverse diameter of the subglottic airway (MTDSA) measured by ...
Buchanan Daniel N - - 2012
The relationship of three-dimensional ultrasound (3DUS)-derived carotid vessel wall volume (VWV) was evaluated with respect to age and sex. B-mode and 3DUS images were acquired for 316 subjects from diverse groups including obese primary prevention, diabetic nephropathy, renal transplant and rheumatoid arthritis populations. The relationship for intima-media thickness (IMT) and VWV ...
Chin Kok-Yong - - 2012
The local normative value in quantitative ultrasound (QUS) equipment needs to be established for wider application and accurate classification of patients into respective fracture risk groups. The present study aimed to establish the calcaneal speed of sound (SOS) value for Chinese and Malay men in Malaysia and determine the difference ...
Williams J E - - 2012
OBJECTIVE: To evaluate whether dual energy x-ray absorptiometry (DXA) and quantitative ultrasound (QUS) classify the same children as 'abnormal' (SD (z) score (SDS) ≤-2). METHODS: Speed of sound (SOS) was measured at the radius and tibia using QUS and lumbar spine bone mineral density (BMD) using DXA in 621 subjects ...
Lubusky Marek - - 2012
Aims. The aim of this study was to assess the feasibility and accuracy of fetal gender assignment by transabdominal ultrasound at 12-14 weeks of gestation. Methods. Fetal gender assessment was performed in 1222 singleton pregnancies. In all fetuses the crown-rump length (CRL) was measured and the genital area of the ...
Lim Sin How SH Department of Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA. - - 2012
This study aimed to examine trajectories with respect to the number of sexual partners among older men who have sex with men and to determine characteristics associated with trajectory groups. Nagin's group-based modeling was used to identify trajectories for 237 men from the Pitt Men's Study with respect to the ...
Deganello A - - 2012
AIM: To describe the prevalence of all forms of scrotal calcification within a symptomatic paediatric population and to compare this with previous reported data in paediatric and adult populations. MATERIALS AND METHODS: A retrospective analysis of testicular ultrasound examinations performed in a single institution over a 55 month period. All ...
Shaikh Z - - 2012
Ultrasound (US) changes within the Achilles tendon are present in asymptomatic Achilles individuals. We assessed the association of US signs with symptoms of Achilles tendinopathy in a study group of club level running athletes and in a control group of athletes training at least 2 times per week. The Achilles ...
Jones Rebecca M RM Autism Research Centre, Psychiatry Department, Cambridge University, Cambridge, UK. - - 2012
The 'extreme male brain' theory suggests females with Autism Spectrum Conditions are hyper-masculinized in certain aspects of behavior. We predicted that females with Gender Identity Disorder (who are masculinized) would have elevated Autism Spectrum Quotient (AQ) scores. AQ scores from five groups were compared: (1) n = 61 transmen (female-to-male transsexual people); ...
Delpachitra Pavitra - - 2012
Accurate determination of gestational age underpins good obstetric care. We assessed the performance of six existing ultrasound reference charts to determine gestational age in 1268 singleton IVF pregnancies, where "true" gestational age could be precisely calculated from date of fertilisation. All charts generated dates significantly different to IVF dates (P ...
Chen You-Peng - - 2012
Environmental alternations leading to fetal programming of cardiovascular diseases in later life have been attributed to maternal factors. However, animal studies showed that paternal obesity may program cardio-metabolic diseases in the offspring. In the current study we tested the hypothesis that paternal BMI may be associated with fetal growth. We ...
Maldonado André Luiz Louzada AL Department of Imaging Diagnostic, Federal University of São Paulo (UNIFESP), 05303-000 São Paulo, SP, - - 2012
Objective. To verify if the placental thickness allows determining the gestational age, evaluating the correlation between the referred gestational age with the studied one, and the accuracy of the placental thickness measurement (biometry) with fetal morphologic parameters in bitches. Methods. The placental thickness of 336 bitches of diverse breeds was ...
Wolski Cyprian - - 2011
At present, there is a number of diagnostic imaging procedures allowing for the evaluation of atherosclerosis. The earliest, subclinical stage of atherosclerosis can be visualized with the development of computed tomography (CT) and ultrasound (US) techniques. Therefore, the purpose of this study was to assess the degree of coronary artery ...
Jung Chang Hee - - 2011
Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, ...
Madimenos Felicia C - - 2011
Minimal data on bone mineral density changes are available from populations in developing countries. Using calcaneal quantitative ultrasound (QUS) techniques, the current study contributes to remedying this gap in the literature by establishing a normative data set on the indigenous Shuar and non-Shuar Colonos of the Ecuadorian Amazon. The paucity ...
Memon Sarwat - - 2011
The aim of this study was to develop a prediction equation for estimating the total widths of the mandibular permanent canines and premolars (TCPW) using the total widths of the mandibular first permanent molars and incisors (TWFMI). The sample comprised 288 mandibular dental casts of orthodontic patients (106 males and ...
1 2 3 4 5 6 7 8 9 10 >