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Kaur Kulbir K Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA; Biology / Neuroscience Graduate Program, City University of New York - Graduate Center, 365 5(th) Avenue, New York, NY 10016, USA; Center for Developmental Neuroscience and Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, - - 2014
Autism is a behaviorally defined neurodevelopmental disorder. Although there is no single identifiable cause for autism, the role of genetic and environmental factors has been implicated in autism. Extensive evidence suggests increased oxidative stress and mitochondrial dysfunction in autism. In the present study, we examined whether bisphenol A (BPA) is ...
Jovanović Darka Sešlija DS Department of Evolutionary Biology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despota Stefana Blvd 142, Belgrade, 11060, Serbia, - - 2014
Mitochondria are suggested to play a central role in ageing and evolution of longevity. Gradual decline in mitochondrial function during ageing and concomitant increase in production of reactive oxygen species (ROS) leads to oxidative damage of macromolecules and impairment of ATP synthesis. To assess relationship between ageing and oxidative stress ...
- - 2014
Essential facts [Figure: see text] Cold weather has a direct effect on the number of people experiencing heart attacks, stroke, respiratory disease and flu. According to the Office for National Statistics, an estimated 31,100 excess winter deaths occurred in England and Wales in 2012/13 - a rise of 29 per ...
Donato Anthony J AJ University of Utah, Department of Internal Medicine, Division of Geriatrics, Salt Lake City, Utah Veteran's Affairs Medical Center-Salt Lake City, Geriatric Research, Education and Clinical Center, Salt Lake City, Utah Department of Exercise and Sports Science, Salt Lake City, - - 2014
The critical influence of the white adipose tissue (WAT) on metabolism is well-appreciated in obesity, but adipose tissue dysfunction as a mechanism underlying age-associated metabolic dysfunction requires elucidation. To explore this possibility, we assessed metabolism and measures of epididymal (e)WAT mitochondria and artery function in young (6.1 ± 0.4 mo) ...
Lauri Andrea A Laboratorio Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino (CCM), IRCCS, Milano, Italy. Electronic address: - - 2014
Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part ...
Szklarczyk Radek R Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands Department of Clinical Genetics, Unit Clinical Genomics, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands - - 2014
Various molecular and cellular pathways are active in eukaryotes to control the quality and integrity of mitochondria. These pathways are involved in keeping a 'healthy' population of this essential organelle during the lifetime of the organism. Quality control (QC) systems counteract processes that lead to organellar dysfunction manifesting as degenerative ...
Mourmoura Evangelia E Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, Université Joseph Fourier, BP 53, 38041, Grenoble cedex 09, - - 2014
This study was aimed at characterizing the functional progression of the endothelial (ECs) and smooth muscle cells (SMCs) of the coronary microvasculature between youth and old age, as well as at determining the mechanisms of the observed changes on the basis of the glucose tolerance, mitochondrial energy metabolism, and oxidative ...
Katewa Subhash D SD Buck Institute for Research on Aging, Novato, CA 94945, - - 2014
One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
Li Luosheng L The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, SE-171 76 Stockholm, - - 2014
Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release and thereby glucose homeostasis is associated with subtle changes in Ca(2+) dynamics in mouse β-cells. We show that these changes are likely to be accounted for by impaired ...
Matias Gonçalo G GlaxoSmithKline Vaccines, Wavre, - - 2014
Influenza and respiratory syncytial virus (RSV) cause substantial mortality from respiratory and other causes in the USA, especially among people aged 65 and older. We estimated the influenza-attributable mortality and RSV-attributable mortality in the USA, stratified by age and risk status, using outcome definitions with different sensitivity and specificity. Influenza- ...
Hur Jae H JH Department of Biology, Harvey Mudd College, Claremont, CA, 91711, USA, - - 2014
The role of mitochondrial complex I in aging has been studied in both C. elegans and Drosophila, where RNAi knock down of specific complex I subunits has been shown to extend lifespan. More recently, studies in Drosophila have shown that an increase in mitochondrial activity, including complex I-like activity, can ...
Tsutsui Yuji Y Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, - - 2014
We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis. We used a NEMA IEC body phantom filled with an (18)F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were ...
Mercken Evi M EM Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, - - 2014
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, ...
Hildebrandt Julia C JC Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, D-72076 Tübingen, - - 2014
Onchocerca ochengi is a nodule-forming filarial nematode parasite of cattle in tropical Africa and closely related to the human pathogen Onchocerca volvulus. The adult worms reside in intradermal nodules. While females are sedentary, males may move between nodules. The first stage larvae (microfilariae) disperse in the skin of the host ...
Jensen Martin Borch MB Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, - - 2014
Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a ...
Rożek-Piechura Krystyna K Department of Physiotherapy, University School of Physical Education in Wroclaw, - - 2014
objective. The aim of this study was to evaluate functioning of the respiratory system and to estimate the correlation between the function parameters of the respiratory system and the level of physical activity and body composition in the adult rural population. The study involved a group of 116 people from ...
Aledo Juan Carlos JC Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071-Málaga, - - 2014
The quest to understand why and how we age has led to numerous lines of investigation that have gradually converged to consider mitochondrial metabolism as a major player. During mitochondrial respiration a small and variable amount of the consumed oxygen is converted to reactive species of oxygen (ROS). For many ...
Das Debangshu D Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, 700 026, - - 2014
The respiratory effects of chronic low-level arsenic exposure from groundwater have been investigated in West Bengal, India. The participants (834 non-smoking adult males) were subdivided in two groups: an arsenic-exposed group (n = 446, mean age 35.3 years) drinking arsenic-contaminated groundwater (11-50 μg/L) and a control group of 388 age-matched men drinking water containing ...
Osborne Neville N NN Fundación de Investigación Oftalmológica, Avda. Doctores Fernández-Vega 34, E-33012 Oviedo, Asturias, Spain. Electronic address: - - 2014
Neurons depend on their mitochondria for optimum function and become susceptible with age. Mitochondrial function is gradually impaired during aging because more electrons are converted to reactive oxygen species rather than being converted to ATP. Retinal ganglion cell mitochondria are additionally affected in glaucoma because of reduced oxygen delivery. Thus, ...
Ottóffy Gábor G Department of Pediatrics, University of Pécs, Pécs, - - 2014
Our aim was to investigate the ecological association between death from infectious disease of the respiratory system and the risk of acute lymphoid leukaemia (ALL) in children aged less than 7 years. Poisson regression analyses were carried out using overall data and gender-specific models. The study included 176 cases (92(52.3 %) boys ...
Pant Niraj N Department of Reproductive Biology, All India Institute of Medical Sciences, (AIIMS), Ansari Nagar, New Delhi, 110029, India, - - 2014
Scientific concern exists about the toxic effect of dichlorodiphenyldichloroethylene (p, p'-DDE) and lindane on male infertility, and the mechanism underlying male reproductive toxicity of this pesticide remains unanswered. We investigated not only the possible association between the chlorinated pesticide levels and semen quality in nonoccupationally exposed men, but also the ...
Callahan Damien M DM 1University of - - 2014
Age-related loss of skeletal muscle mass and function is implicated in the development of disease and physical disability. However, little is known about how age affects skeletal muscle structure at the cellular and ultrastructural levels or how such alterations impact function. Thus, we examined skeletal muscle structure at the tissue, ...
Sgarbi Gianluca G DIBINEM, Department of Biomedical and Neuromotor Sciences University of Bologna, 40126 Bologna, - - 2014
Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated from the skin ...
Frech Tracy M TM Division of Rheumatology, Department of Internal Medicine, University of Utah, USA; Salt Lake Regional Veterans Affair Medical - - 2014
Objectives: The aim of this research was to examine parental influence on the development of Systemic Sclerosis (SSc). We designed three studies: (1) mitochondrial inheritance; (2) birth order (a possible surrogate marker for microchimerism); and (3) paternal age at conception (a possible surrogate for telomere erosion) to examine their association ...
Porter George - - 2014
Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related damage to mitochondria may be a critical feature, which manifests in an exacerbation of IR injury. SIRT3, the major mitochondrial NAD(+)-dependent lysine deacetylase, regulates a variety of functions and its inhibition may disrupt ...
Liu Ye Y Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, - - 2014
First proposed by D Harman in the 1950s, the Mitochondrial Free Radical Theory of Aging (MFRTA) has become one of the most tested and well-known theories in aging research. Its core statement is that aging results from the accumulation of oxidative damage, which is closely linked with the release of ...
Aguilar-Toral Roxana R Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Avenida Fco. J. Mújica S/N, Morelia, Mich, 58030, - - 2014
Increased membrane unsaturation has been associated with shorter longevity due to higher sensitivity to lipid peroxidation (LP) leading to enhanced mitochondrial dysfunction and ROS overproduction. However, the role of LP during aging has been put in doubt along with the participation of electron leak at the electron transport chain (ETC) ...
Johannessen Ane - - 2014
Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bias may be present in their material and what characterizes the ...
Szabo Shelagh M SM ICON Epidemiology, Vancouver, British Columbia, - - 2014
To estimate the risk of childhood chronic respiratory morbidity among those hospitalized for severe lower respiratory tract infection (LRTI) in early childhood, and to determine whether severe LRTI is an independent predictor. The population-based Régie de l'Assurance Maladie du Québec datasets were used to identify LRTI hospitalizations before age 2 years ...
Dia Ndongo - - 2014
In Africa, especially in West Africa, studies about the prevalence and diversity of respiratory viruses (influenza and others) in elderly people are largely lacking. In studies done elsewhere, it is well established that older people, when compared with younger adults, are at greater risk of significant morbidity and mortality from ...
Gulec Balbay Ege E Düzce University, Medical Faculty, Department of Chest Diseases, Düzce, - - 2014
Introduction and aim. The presented study was undertaken to investigate the respiratory health problems in family barns with one or more cows and at least one family member working in the barn. Methods. 150 workers (128 female, 22 male) from 4 villages of Yığılca district near the city of Düzce ...
Stauch Kelly L KL Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, - - 2014
Aging correlates with a progressive impairment of mitochondrial homeostasis and is an influential factor for several forms of neurodegeneration. However, the mechanisms underlying age-related alterations in synaptosomal mitochondria, a neuronal mitochondria population highly susceptible to insults and critical for brain function, remain incompletely understood. Therefore this study investigates the synaptic ...
Zang Qun S QS Departments of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, - - 2014
The incidence of sepsis and its attendant mortality risk are significantly increased with aging. Thus, severe sepsis in the elderly is likely to become an emerging concern in critical care units. Cardiac dysfunction is an important component of multi-organ failure after sepsis. In our laboratory, utilizing a pneumonia-related sepsis animal ...
Poulose Ninu N Department of Medical Laboratory, Imaging and Radiological Sciences, Georgia Regents University, Augusta, GA30912, - - 2014
Aging is characterized by increased oxidative stress, heightened inflammatory response, accelerated cellular senescence and progressive organ dysfunction. The homeostatic imbalance with aging significantly alters cellular responses to injury. Though it is unclear whether cellular energetic imbalance is a cause or effect of the aging process, preservation of mitochondrial function has ...
Assunção Silvana Neves Ferraz de SN Professor Edgard Santos University Hospital, School of Medicine, Federal University of Bahia, Salvador, - - 2014
To describe lung function findings in overweight children and adolescents without respiratory disease. This was a cross-sectional study involving male and female overweight children and adolescents in the 8-18 year age bracket, without respiratory disease. All of the participants underwent anthropometric assessment, chest X-ray, pulse oximetry, spirometry, and lung volume ...
Kalfalah Faiza F Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich-Heine-University, Med. Faculty, Düsseldorf, - - 2014
Extrinsic skin ageing converges on the dermis, a post-mitotic tissue compartment consisting of extracellular matrix and long-lived fibroblasts prone to damage accumulation and maladaptation. Aged human fibroblasts exhibit mitochondrial and nuclear dysfunctions, which may be a cause or consequence of ageing. We report on a systematic study of human dermal ...
Colom Bartomeu B Centre for Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. - - 2014
The incidence of cardiac disease is age and sex dependent, but the mechanisms governing these associations remain poorly understood. Mitochondria are the organelles in charge of producing energy for the cells, and their malfunction has been linked to cardiovascular disease and heart failure. Interestingly, heart mitochondrial content and functionality are ...
Zhang Yingmei Y Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071 USA; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032. Electronic address: - - 2014
Cardiac aging is associated with compromised myocardial function and morphology although the underlying mechanism remains elusive. ALDH2, an essential mitochondrial enzyme governing cardiac function, displays polymorphism in human. This study was designed to examine the role of ALDH2 in aging-induced myocardial anomalies. Myocardial mechanical and intracellular Ca(2+) properties were examined ...
Selman Moisés M Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico ; - - 2014
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the biopathological processes linking aging with IPF and the mechanisms responsible for the abnormal activation of epithelial cells ...
Wohlgemuth Stephanie E SE Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA. Electronic address: - - 2014
Aging is accompanied by a progressive increase in the incidence and prevalence of cardiovascular disease (CVD). The prolonged exposure to cardiovascular risk factors, together with intrinsic age-dependent declines in cardiac functionality, increases the vulnerability of the heart to both endogenous and exogenous stressors, ultimately enhancing the susceptibility to developing CVD ...
Gkotsi Despoina D Institute of Ophthalmology University College - - 2014
Progressive accumulation of age related mitochondrial DNA mutations reduce ATP production and increase reactive oxygen species output, leading to oxidative stress, inflammation and degradation. The pace of this is linked to metabolic demand. The retina has the greatest metabolic demand and mitochondrial density in the body and displays progressive age ...
Cao Weiwei W Lab of Pharmacology and Toxicology, School of Pharmaceutical Science, Sun Yat-sen University, East of Ring Road No. 132, Guangzhou Higher Education Mega Center, Guangdong, 510006, - - 2014
Advanced glycation end products (AGEs) and dendritic cells (DCs) are believed to play a key role in the development and progression of cardiovascular diseases. However, their role and interactive mechanism remain uncertain. The aim of the present study is to investigate the mechanism of AGE- and DC-mediated heart failure. Time- ...
Rippo Maria Rita MR Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Universita` Politecnica delle Marche, Ancona, Italy. Electronic address: - - 2014
Mitochondria are intimately involved in the aging process. The decline of autophagic clearance during aging affects the equilibrium between mitochondrial fusion and fission, leading to a build-up of dysfunctional mitochondria, oxidative stress, chronic low-grade inflammation, and increased apoptosis rates, the main hallmarks of aging. Current research suggests that a large ...
Whelan Fiona J FJ McMaster University, Department of Biochemistry and Biomedical Sciences, Hamilton, Ontario, Canada, McMaster University, Institute for Infectious Disease Research, Hamilton, Ontario, Canada ; - - 2014
Rationale: The microbial communities inhabiting the upper respiratory tract protect from respiratory infection. The maturity of the immune system is believed to be a major influence on the composition of the microbiome and, in youth, the microbiota and immune system are believed to mature in tandem. With age, immune function ...
Gurley Emily S - - 2014
The timing of a child's first acute lower respiratory infection (ALRI) is important, because the younger a child is when he or she experiences ALRI, the greater the risk of death. Indoor exposure to particulate matter less than or equal to 2.5 µm in diameter (PM2.5) has been associated with ...
Nisoli Enzo - - 2014
Healthy mitochondria are essential generators of cellular energy, while senescent or damaged mitochondria are bio-energetically inefficient and are sources of reactive oxygen species. The mitochondrial life cycle, comprising biogenesis, fusion/fission events and mitophagic elimination, is carefully orchestrated, and age-related decay of the lifecycle contributes to chronic degenerative diseases. Mitochondria make ...
Schiavi Alfonso A IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; University of Rome "Tor Vergata", 00133 Rome, - - 2014
Mitochondria are highly dynamic organelles which play a central role in cellular homeostasis. Mitochondrial dysfunction leads to life-threatening disorders and accelerates the aging process. Surprisingly, on the other hand, a mild reduction of mitochondria functionality can have pro-longevity effects in organisms spanning from yeast to mammals. Autophagy is a fundamental ...
Christian Brooke E BE Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, - - 2014
Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.
Moran Andrew E AE Columbia University Medical Center, New York, - - 2014
Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with three non-fatal IHD sequelae: nonfatal acute myocardial infarction (AMI), angina pectoris, and ischemic heart failure. Our aim was to estimate global and regional burden of IHD in 1990 and 2010. ...
van Leeuwen N N Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The - - 2014
Long-lived individuals delay aging and age-related diseases like diabetes, hypertension, and cardiovascular disease. The exact underlying mechanisms are largely unknown, but enhanced mitochondrial biogenesis and preservation of mitochondrial function have been suggested to explain healthy ageing. We investigated whether individuals belonging to long-lived families have altered mitochondrial DNA (mtDNA) content, ...
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