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Aguilar-Toral Roxana R Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Avenida Fco. J. Mújica S/N, Morelia, Mich, 58030, - - 2014
Increased membrane unsaturation has been associated with shorter longevity due to higher sensitivity to lipid peroxidation (LP) leading to enhanced mitochondrial dysfunction and ROS overproduction. However, the role of LP during aging has been put in doubt along with the participation of electron leak at the electron transport chain (ETC) ...
Johannessen Ane - - 2014
Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bias may be present in their material and what characterizes the ...
Dia Ndongo - - 2014
In Africa, especially in West Africa, studies about the prevalence and diversity of respiratory viruses (influenza and others) in elderly people are largely lacking. In studies done elsewhere, it is well established that older people, when compared with younger adults, are at greater risk of significant morbidity and mortality from ...
Szabo Shelagh M SM ICON Epidemiology, Vancouver, British Columbia, - - 2014
To estimate the risk of childhood chronic respiratory morbidity among those hospitalized for severe lower respiratory tract infection (LRTI) in early childhood, and to determine whether severe LRTI is an independent predictor. The population-based Régie de l'Assurance Maladie du Québec datasets were used to identify LRTI hospitalizations before age 2 years ...
Poulose Ninu N Department of Medical Laboratory, Imaging and Radiological Sciences, Georgia Regents University, Augusta, GA30912, - - 2014
Aging is characterized by increased oxidative stress, heightened inflammatory response, accelerated cellular senescence and progressive organ dysfunction. The homeostatic imbalance with aging significantly alters cellular responses to injury. Though it is unclear whether cellular energetic imbalance is a cause or effect of the aging process, preservation of mitochondrial function has ...
Zang Qun S QS Departments of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, - - 2014
The incidence of sepsis and its attendant mortality risk are significantly increased with aging. Thus, severe sepsis in the elderly is likely to become an emerging concern in critical care units. Cardiac dysfunction is an important component of multi-organ failure after sepsis. In our laboratory, utilizing a pneumonia-related sepsis animal ...
Gulec Balbay Ege E Düzce University, Medical Faculty, Department of Chest Diseases, Düzce, - - 2014
Introduction and aim. The presented study was undertaken to investigate the respiratory health problems in family barns with one or more cows and at least one family member working in the barn. Methods. 150 workers (128 female, 22 male) from 4 villages of Yığılca district near the city of Düzce ...
Kalfalah Faiza F Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich-Heine-University, Med. Faculty, Düsseldorf, - - 2014
Extrinsic skin ageing converges on the dermis, a post-mitotic tissue compartment consisting of extracellular matrix and long-lived fibroblasts prone to damage accumulation and maladaptation. Aged human fibroblasts exhibit mitochondrial and nuclear dysfunctions, which may be a cause or consequence of ageing. We report on a systematic study of human dermal ...
Colom Bartomeu B Centre for Microvascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. - - 2014
The incidence of cardiac disease is age and sex dependent, but the mechanisms governing these associations remain poorly understood. Mitochondria are the organelles in charge of producing energy for the cells, and their malfunction has been linked to cardiovascular disease and heart failure. Interestingly, heart mitochondrial content and functionality are ...
Zhang Yingmei Y Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071 USA; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032. Electronic address: - - 2014
Cardiac aging is associated with compromised myocardial function and morphology although the underlying mechanism remains elusive. ALDH2, an essential mitochondrial enzyme governing cardiac function, displays polymorphism in human. This study was designed to examine the role of ALDH2 in aging-induced myocardial anomalies. Myocardial mechanical and intracellular Ca(2+) properties were examined ...
Clay Candice C - - 2014
Many respiratory viruses disproportionately impact the elderly. Likewise, advanced age correlated with more adverse disease outcomes following severe acute respiratory syndrome coronavirus (SARS-CoV) infection in humans. We used an aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Nonhuman primates ...
Selman Moisés M Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico ; - - 2014
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the biopathological processes linking aging with IPF and the mechanisms responsible for the abnormal activation of epithelial cells ...
Wohlgemuth Stephanie E SE Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA. Electronic address: - - 2014
Aging is accompanied by a progressive increase in the incidence and prevalence of cardiovascular disease (CVD). The prolonged exposure to cardiovascular risk factors, together with intrinsic age-dependent declines in cardiac functionality, increases the vulnerability of the heart to both endogenous and exogenous stressors, ultimately enhancing the susceptibility to developing CVD ...
Gkotsi Despoina D Institute of Ophthalmology University College - - 2014
Progressive accumulation of age related mitochondrial DNA mutations reduce ATP production and increase reactive oxygen species output, leading to oxidative stress, inflammation and degradation. The pace of this is linked to metabolic demand. The retina has the greatest metabolic demand and mitochondrial density in the body and displays progressive age ...
Cao Weiwei W Lab of Pharmacology and Toxicology, School of Pharmaceutical Science, Sun Yat-sen University, East of Ring Road No. 132, Guangzhou Higher Education Mega Center, Guangdong, 510006, - - 2014
Advanced glycation end products (AGEs) and dendritic cells (DCs) are believed to play a key role in the development and progression of cardiovascular diseases. However, their role and interactive mechanism remain uncertain. The aim of the present study is to investigate the mechanism of AGE- and DC-mediated heart failure. Time- ...
Rippo Maria Rita MR Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Universita` Politecnica delle Marche, Ancona, Italy. Electronic address: - - 2014
Mitochondria are intimately involved in the aging process. The decline of autophagic clearance during aging affects the equilibrium between mitochondrial fusion and fission, leading to a build-up of dysfunctional mitochondria, oxidative stress, chronic low-grade inflammation, and increased apoptosis rates, the main hallmarks of aging. Current research suggests that a large ...
Gurley Emily S - - 2014
The timing of a child's first acute lower respiratory infection (ALRI) is important, because the younger a child is when he or she experiences ALRI, the greater the risk of death. Indoor exposure to particulate matter less than or equal to 2.5 µm in diameter (PM2.5) has been associated with ...
Whelan Fiona J FJ McMaster University, Department of Biochemistry and Biomedical Sciences, Hamilton, Ontario, Canada, McMaster University, Institute for Infectious Disease Research, Hamilton, Ontario, Canada ; - - 2014
Rationale: The microbial communities inhabiting the upper respiratory tract protect from respiratory infection. The maturity of the immune system is believed to be a major influence on the composition of the microbiome and, in youth, the microbiota and immune system are believed to mature in tandem. With age, immune function ...
Nisoli Enzo - - 2014
Healthy mitochondria are essential generators of cellular energy, while senescent or damaged mitochondria are bio-energetically inefficient and are sources of reactive oxygen species. The mitochondrial life cycle, comprising biogenesis, fusion/fission events and mitophagic elimination, is carefully orchestrated, and age-related decay of the lifecycle contributes to chronic degenerative diseases. Mitochondria make ...
Schiavi Alfonso A IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; University of Rome "Tor Vergata", 00133 Rome, - - 2014
Mitochondria are highly dynamic organelles which play a central role in cellular homeostasis. Mitochondrial dysfunction leads to life-threatening disorders and accelerates the aging process. Surprisingly, on the other hand, a mild reduction of mitochondria functionality can have pro-longevity effects in organisms spanning from yeast to mammals. Autophagy is a fundamental ...
Christian Brooke E BE Departments of Pathology, Yale School of Medicine, New Haven, CT 06520, - - 2014
Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.
Moran Andrew E AE Columbia University Medical Center, New York, - - 2014
Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with three non-fatal IHD sequelae: nonfatal acute myocardial infarction (AMI), angina pectoris, and ischemic heart failure. Our aim was to estimate global and regional burden of IHD in 1990 and 2010. ...
van Leeuwen N N Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The - - 2014
Long-lived individuals delay aging and age-related diseases like diabetes, hypertension, and cardiovascular disease. The exact underlying mechanisms are largely unknown, but enhanced mitochondrial biogenesis and preservation of mitochondrial function have been suggested to explain healthy ageing. We investigated whether individuals belonging to long-lived families have altered mitochondrial DNA (mtDNA) content, ...
Plohnke Nicole N Plant Biochemistry, Faculty of Biology & Biotechnology, Ruhr University Bochum, D-44780 Bochum, Germany. Electronic address: - - 2014
The mitochondrial free radical theory of aging (MFRTA) states that reactive oxygen species (ROS) generated at the respiratory electron transport chain are active in causing age-related damage of biomolecules like lipids, nucleic acids and proteins. Accumulation of this kind of damage results in functional impairments, aging and death of biological ...
Pacheco A P AP Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, - - 2014
Despite the increasing number of geriatric horses attended by veterinarians, there is a lack of understanding of aging-related changes on the respiratory system of horses. To identify aging-related changes on the respiratory function and bronchoalveolar lavage fluid (BALF) cytology of horses. Fifteen healthy young adult (2-11 years) and 16 healthy aged ...
Regmi Saroj G SG Center for Integrated Protein Science Munich - CIPSM, Department Biology II, Ludwig-Maximilians-University, Munich, 82152 Planegg-Martinsried, - - 2014
Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One mechanism through which mitochondrial dysfunction can be caused is through changes in mitochondrial morphology. To determine the role of mitochondrial morphology changes in age-dependent mitochondrial dysfunction, we studied mitochondrial morphology in body wall muscles of the nematodeC. elegans. ...
Shen En-Zhi EZ 1] College of Biological Sciences, China Agricultural University, Beijing 100094, China [2] National Institute of Biological Sciences, Beijing, Beijing 102206, China - - 2014
It has been theorized for decades that mitochondria act as the biological clock of ageing, but the evidence is incomplete. Here we show a strong coupling between mitochondrial function and ageing by in vivo visualization of the mitochondrial flash (mitoflash), a frequency-coded optical readout reflecting free-radical production and energy metabolism ...
Mészáros Desiree D Menzies Research Institute, University of Tasmania, Hobart, Tasmania, - - 2014
The role of indoor air pollution as a risk factor for asthma and respiratory symptoms in middle age is unclear. We investigated associations between indoor air pollution sources and (i) asthma phenotypes and (ii) asthma-related respiratory symptoms in middle-aged adults. Subjects (n = 5729) who participated in the 2004 survey ...
Tepper Leonie A LA Department of Pediatric Pulmonology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The - - 2014
Cystic fibrosis (CF) lung disease is characterized by bronchiectasis and trapped air on chest computed tomography (CT). We aim to validate bronchiectasis and trapped air as outcome measures by evaluating associations between changes in bronchiectasis, trapped air and patient-reported respiratory symptoms. A longitudinal cohort study has been conducted. CF patients ...
Hovland K H KH Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, N-0033 Oslo, - - 2014
BackgroundThis study is part of a 3-year follow-up of lung function among nitrate fertilizer production workers.AimsTo study the possible adverse effects of occupational exposure to aerosols and gases on pulmonary diffusing capacity.MethodsA longitudinal study of a cohort of fertilizer workers who performed single-breath carbon monoxide diffusing capacity (DLco) tests and ...
Ureshino Rodrigo Portes RP Federal University of Sao Paulo, Pharmacology, Sao Paulo, Brazil ; - - 2014
Significance: Aging is a multi-factorial process that may be associated with several functional and structural deficits that can evolve into degenerative diseases. In this review, we present data that may depict an expanded view of molecular aging theories, beginning with the idea that reactive oxygen species (ROS) are the major ...
Wang Yue-Hua YH National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, - - 2014
Advanced glycation end products (AGEs) have been identified in age-related intracellular protein deposits of neurodegenerative diseases. Methylglyoxal (MGO), a dicarbonyl metabolite, is a major precursor of AGEs which have been linked to the development of neurodegenerative diseases. Myricitrin, a flavanoid isolated from the root bark of Myrica cerifera, attenuated 6-OHDA-induced ...
Zhao Lin L Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Life Science, FIST, Xi'an Jiaotong University, Xi'an, - - 2014
Adipogenesis and lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic, age-related diseases. However, little is known about the age-related molecular changes in lipid accumulation and the mechanisms underlying them. Here, using 5-month- and 25-month-old rats (young and old, respectively), we found ...
Bulstrode H H University College London, Cancer Institute, London, - - 2014
Objective: Traumatic brain injury (TBI) is a multi-factorial pathology with great inter-individual variability in response to injury and outcome. Mitochondria contain their own DNA (mtDNA) with genomic variants that have different physiological and pathological characteristics, including susceptibility to neurodegeneration. Given the central role of mitochondria in the pathophysiology of neurological ...
Koyama Keisuke K Laboratory of Theriogenology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, - - 2014
The objective of this research was to clarify the aging-related changes in in vitro-matured bovine oocytes. Firstly, we examined the fertilization and embryonic development of bovine oocytes after 22 and 30-34 h of in vitro maturation (IVM). The oocytes after 30-34 h of IVM (penetrated by sperm at around 40 h ...
Dumit Verónica I VI 1] Freiburg Institute for Advanced Studies (FRIAS); School of Life Science (LifeNet), University of Freiburg, Freiburg, Germany [2] Center for Biological Systems Analysis (ZBSA), Philadelphia, PA, - - 2014
Aging is a common risk factor of many disorders. With age, the level of insoluble extracellular matrix increases leading to increased stiffness of a number of tissues. Matrix accumulation can also be observed in fibrotic disorders, such as systemic sclerosis (SSc). Although the intrinsic aging process in skin is phenotypically ...
Prolla Tomas A TA Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA. Electronic address: - - 2014
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) ...
Dechert Ronald E RE From the Departments of Surgery, University of Michigan, Ann Arbor, - - 2014
The oxygenation index (mean airway pressure × FIO2 divided by PaO2) was originally devised to measure severity of illness and predict outcome in neonatal respiratory failure. We evaluated the discrimination of a modified oxygenation index (modified with age) for predicting 28-day mortality in adults with respiratory failure (adult respiratory distress ...
Kredentser Maia S MS Manitoba Palliative Care Research Unit, 3017-675 McDermot Ave, Winnipeg, Manitoba, Canada R3E 0V9 - - 2014
To compare the causes and rates of death for people with and without schizophrenia in Manitoba, Canada. Using de-identified administrative databases at the Manitoba Centre for Health Policy, a population-based analysis was performed to compare age- and sex-adjusted 10-year (1999-2008) mortality rates, overall and by specific cause, of decedents aged ...
Regmi Saroj G SG Center for Integrated Protein Science Munich - CIPSM, Department Biology II, Ludwig-Maximilians-University, Munich, 82152 Planegg-Martinsried, - - 2014
Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One mechanism through which mitochondrial dysfunction can be caused is through changes in mitochondrial morphology. To determine the role of mitochondrial morphology changes in age-dependent mitochondrial dysfunction, we studied mitochondrial morphology in body wall muscles of the nematodeC. elegans. ...
Rambags B P B BP Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, The - - 2014
In many mammalian species, reproductive success decreases with maternal age. One proposed contributor to this age-related decrease in fertility is a reduction in the quantity or functionality of mitochondria in oocytes. This study examined whether maternal age or (in vitro maturation). IVM affect the quantity of mitochondria in equine oocytes. ...
Pinti Marcello M Department of Life Sciences, University of Modena and Reggio Emilia, Modena, - - 2014
Mitochondrial components, including mitochondrial DNA (mtDNA), when released extracellularly, can act as "damage-associated molecular pattern" (DAMP) agents and cause inflammation. As many elderly people are characterized by a low-grade, chronic inflammatory status defined "inflamm-aging", we evaluated if circulating mtDNA can contribute to this phenomenon. Eight hundred and thirty-one Caucasian subjects ...
Szafranski Kirk K Department of Laboratory Medicine and Pathobiology; Faculty of Medicine, University of Toronto; Toronto, ON - - 2014
Caloric restriction (CR) is generally linked to lifespan extension in various organisms and may limit age-associated diseases. Processes through which caloric restriction promotes lifespan include obesity-countering weight loss, increased DNA repair, control of ribosomal and telomeric DNA repeats, mitochondrial regulation, activation of antioxidants, and protective autophagy. Several of these protective ...
Liang Vanessa V Brain and Mind Research Institute, University of Sydney, Camperdown, 2050, - - 2014
Protein misfolding and aggregation as a consequence of impaired protein homeostasis (proteostasis) not only characterizes numerous age-related diseases but also the aging process itself. Functionally related to the aging process are, among others, ribosomal proteins, suggesting an intimate link between proteostasis and aging. We determined by iTRAQ quantitative proteomic analysis ...
Long Yun Chau YC 1Yong Loo Lin School of Medicine National University of - - 2014
Cellular and organ metabolism affects organismal lifespan. Aging is characterized by increased risks for metabolic disorders, with age-associated degenerative diseases exhibiting varying degrees of mitochondrial dysfunction. The traditional view of the role of mitochondria generated reactive oxygen species (ROS) in cellular aging, assumed to be causative and simply detrimental for ...
He Yong-Han YH State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China; KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, - - 2014
Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function. A decline in the mtDNA content and subsequent dysfunction cause various senile diseases, with decreasing mtDNA content observed in the elderly individuals with age-related diseases. In contrast, the oldest old individuals, for example, centenarians, ...
Mulligan Christopher M CM *These authors contributed equally to this - - 2014
Aging results in a redistribution of polyunsaturated fatty acids (PUFAs) in myocardial phospholipids. In particular, a selective loss of linoleic acid (18:2n6) with reciprocal increases of long-chain PUFAs (eg, arachidonic and docosahexaenoic acids) in the mitochondrial phospholipid cardiolipin correlates with cardiac mitochondrial dysfunction and contractile impairment in aging and related ...
Mendelsohn Andrew R AR Panorama Research Institute, 1230 Bordeaux Dr, Sunnyvale, California, United States, 94089, 408-747-5201, Regenerative Sciences Institute, , 1230 Bordeaux Dr, Sunnyvale, California, United States, 94089, 650-965-1544 ; - - 2014
That some aging-associated phenotypes may be reversible, is an emerging theme in contemporary aging research. Gomes et al. report that age-associated oxidative phosphorylation (OXPHOS) defects in murine skeletal muscle are biphasic. In the first phase oxidative phosphorylation is decreased because of reduced expression of mitochondrially encoded genes. Treatment of moderately ...
Tam Zhi Yang ZY Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland. - - 2014
Aging has been associated with the accumulation of damages in molecules and organelles in cells, particularly mitochondria. The rate of damage accumulation is closely tied to the turnover of the affected cellular components. Perturbing mitochondrial turnover has been shown to significantly affect the rate of deterioration of mitochondrial function with ...
Abou-Elwafa Hala Samir - - 2014
ABSTRACT This research assessed the prevalence of respiratory complaints and the occupational risk factors among municipal solid waste (MSW) collectors. A comparative study was conducted upon MSW collectors in Western Municipality of Mansoura. Sociodemographic and occupational data were collected. Clinical examination and respiratory function measurements were performed. The prevalence of ...
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