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Mirsaeidi Mehdi - - 2014
Background.The clinical presentation and outcome of sarcoidosis varies by race. However, the race difference in mortality outcome remains largely unknown. Methods.We studied mortality related to sarcoidosis from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. We compared the comorbid conditions between sarcoidosis related deaths ...
Arnaud Laurent L Department of internal medicine & French National Reference Center For Systemic Lupus and the Antiphospholipid Syndrome, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 47-83 bd de l'hôpital, F-75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, F-75005 Paris, France. Electronic address: - - 2014
To date, only a small number of studies have examined the epidemiology of systemic lupus erythematosus (SLE) on a nation-wide basis. We used French national administrative databases to analyze the nation-wide prevalence and incidence rates of SLE within the largest French health insurance scheme, which covers 86% of the population ...
Labat-Robert J J Laboratoire de recherche ophtalmologique, hôtel-Dieu, université Paris 5, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, - - 2014
Longevity and aging are differently regulated. Longevity has an important part of genetic determinants, aging is essentially post-genetic. Among the genes involved in longevity determination, sirtuins, activated also by calorie restriction and some others as the TOR pathway, attracted special interest after the insulin-IGF pathway first shown to regulate longevity ...
Tsai Jeng-Dau JD Institute of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan ; Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, - - 2014
Systemic lupus erythematosus (SLE) affects central and peripheral nervous systems, manifesting neuropsychiatric disorders that vary from subtle signs to life-threatening complications. This study compared the risk of epilepsy between a general population and patients with SLE. From the national insurance claims data of the Taiwan National Health Research Institutes, we ...
Eysteinsdottir T - - 2013
Association between bone mineral density and bone mineral content in old age and milk consumption in adolescence, midlife, and old age was assessed. The association was strongest for milk consumption in midlife: those drinking milk daily or more often had higher bone mineral density and content in old age than ...
Manna Soumen K SK Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, - - 2013
Development of methods for rapid screening and stratification of subjects after exposure is an integral part of countermeasures against radiation. The potential demographic and exposure history-related heterogeneity of exposed populations warrants robust biomarkers that withstand and reflect such differences. In this study, the effect of aging and repeated exposure on ...
Ramezani Tehrani Fahimeh - - 2013
Studies indicate that milk intake is associated with insulin-like growth factor 1 (IGF-1) concentrations and height in childhood, whether milk and other dairy products promote puberty remains unclear. This study aimed to investigate influences of pre-pubertal intakes of milk, yogurt and cheese on menarcheal age in Tehranian girls. The associations ...
Brandlová Karolína - - 2013
Allosuckling is a situation when a female nurses a non-filial offspring. It was described in various ungulate species; however for camels this is the first description of this behaviour. The aim of the study was to assess the occurrence of allosuckling in captive camels (Camelus bactrianus) and to test whether ...
Morgan Jessica - - 2012
The present study examined adult age and sex differences in self-reported aspirations and personal meaning. Young, midlife, and older adults (N = 2,557) from the United Kingdom or United States completed an online survey of their aspiration striving, aspiration importance, and personal meaning (subscales of Purposeful Life, Exciting Life, Accomplished ...
- - 2012
Reports an error in "Uncertain aspirations for continuing in education: Antecedents and associated outcomes" by Leslie Morrison Gutman, Ingrid Schoon and Ricardo Sabates (Developmental Psychology, Advanced Online Publication, Dec 19, 2011, np). There is an error in the last line of Table 2. It should read "Uncertain Aspirations → Enrollment ...
Butler Susan G - - 2012
To identify treatable risk factors for aspiration in older adults, particularly those associated with sarcopenia, we examined tongue composition. We hypothesized that isometric and swallowing posterior tongue strength would positively correlate with posterior tongue adiposity, and healthy older adults who aspirate would have greater tongue adiposity than healthy older adults ...
Seshadri Krishna G - - 2012
Art through the ages has been a marker of societal trends and fashion. Obesity is proscribed by physicians and almost reviled by today's society. While Venus (Aphrodite) continues to be the role model for those to aspire to free themselves from the clutches of obesity, Paleolithic humans had a different ...
Uchiki Tomoaki T Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, - - 2012
Epidemiologic studies indicate that the risks for major age-related debilities including coronary heart disease, diabetes, and age-related macular degeneration (AMD) are diminished in people who consume lower glycemic index (GI) diets, but lack of a unifying physiobiochemical mechanism that explains the salutary effect is a barrier to implementing dietary practices ...
Hasan K M Mehedi KM Biotechnology and Genetic Engineering Discipline, Khulna University, Bangladesh. - - 2012
Psychological stress has extreme adverse consequences on health. However, the molecular mechanisms that mediate and accelerate the process of aging due to stress hormone are not well defined. This review has focused on diverse molecular paths that come out in response to chronic psychological stress via releasing of excessive glucocorticoids ...
Dasuri Kalavathi K Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, - - 2011
Intracellular proteins are degraded by a number of proteases, including the ubiquitin-proteasome pathway (UPP). Impairments in the UPP occur during the aging of a variety of tissues, although little is known in regards to age-related alterations to the UPP during the aging of adipose tissue. The UPP is known to ...
Dragovic Srdjan M - - 2011
Cytoplasmic Ags derived from viruses, cytosolic bacteria, tumors, and allografts are presented to T cells by MHC class I or class II molecules. In the case of class II-restricted Ags, professional APCs acquire them during uptake of dead class II-negative cells and present them via a process called indirect presentation. ...
Das Debjani - - 2011
Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers' brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers'. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. ...
Peters Jan J Department of Systems Neuroscience, Universitaetsklinikum Hamburg-Eppendorf, Germany. - - 2011
Adolescents are particularly vulnerable to addiction, and in the case of smoking, this often leads to long-lasting nicotine dependence. The authors investigated a possible neural mechanism underlying this vulnerability. Functional MRI was performed during reward anticipation in 43 adolescent smokers and 43 subjects matched on age, gender, and IQ. The ...
Merriman Harold L - - 2011
Though popular, there is little agreement on what whole-body vibration (WBV) parameters will optimize performance. This study aimed to clarify the effects of age, sex, hertz and time on four physical function indicators in community-dwelling older adults (N = 32). Participants were exposed to 2 min WBV per session at either ...
Lagunov Alexander - - 2011
The objective of this study was to determine the effect of in utero and lactational exposure to nicotine on the male reproductive tract. Dams were randomly assigned to receive saline or nicotine bitartrate (1mg/kg-d s.c.) daily for two weeks prior to mating until weaning (postnatal day 21). Male offspring were ...
Lopez-Quintero Catalina C New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, - - 2011
This study aims to estimate general and racial-ethnic specific cumulative probability of developing dependence among nicotine, alcohol, cannabis or cocaine users, and to identify predictors of transition to substance dependence. Analyses were done for the subsample of lifetime nicotine (n=15,918), alcohol (n=28,907), cannabis (n=7389) or cocaine (n=2259) users who participated ...
Mackinlay Elizabeth - - 2010
Spiritual reminiscence is a way of telling a life story with emphasis on meaning. Spiritual reminiscence can identify meaning associated with joy, sadness, anger, guilt, or regret. Exploring these issues in older age can help people to reframe some of these events and come to new understanding of the meaning ...
Sinka Lidia - - 2010
The relative contributions of Alzheimer disease (AD) and vascular lesion burden to the occurrence of cognitive decline are more difficult to define in the oldest-old than they are in younger cohorts. To address this issue, we examined 93 prospectively documented autopsy cases from 90 to 103 years with various degrees ...
Gao Sujuan S Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA. - - 2011
To examine the association between changes in body mass index (BMI), dementia, and mild cognitive impairment (MCI). Prospective observational study. Urban community in Indianapolis, Indiana. Participants were African Americans aged 65 and older enrolled in the Indianapolis Dementia Project and followed through 2007. This analysis included 1,331 participants who did ...
Katsarou Zoe - - 2010
A translated version of the Mattis Dementia Rating Scale (DRS) into Greek ((DRS-GR) was applied to a sample of Greek population (N = 356) comprising normal middle-aged and elderly subjects (controls), as well as patients suffering from Parkinson's (PD) and Alzheimer's disease (AD) to test its reliability and validity. A ...
Lee Sang E - - 2010
To better understand conceptualizations of dementia, this study explored causal attributions of dementia among 209 Korean Americans, using a self-administered questionnaire in Korean. Findings show that Korean Americans endorsed various causal attributions. Factor analysis yielded 3 dimensions of their attributions including psychological, physical/environmental, and cognitive/social. Bivariate analyses showed that younger ...
Borson Soo S Alzheimer's Disease Research Center Satellite, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, 98195-6560, USA. - - 2010
Accurate assessment of the effect of dementia on healthcare utilization and costs requires separation of the effects of comorbid conditions, often poorly accounted for in existing claims-based studies. To determine whether two different types of comorbidity and risk adjustment scales, the Chronic Disease Score (CDS) and the Cumulative Illness Rating ...
Forsaa E B - - 2010
OBJECTIVE: To identify independent risk factors of mortality in a community-based Parkinson disease (PD) cohort during prospective long-term follow-up. METHODS: A community-based prevalent sample of 230 patients with PD from southwestern Norway was followed prospectively with repetitive assessments of motor and nonmotor symptoms from 1993 to 2005. Information on vital ...
Ubhi Kiren K Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, - - 2010
Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder of the aging population characterized by α-synuclein accumulation in cortical and subcortical regions. Although neuropathology in advanced age has been investigated in dementias such as Alzheimer Disease (AD), severity of the neuropathology in the oldest old with DLB remains uncharacterized. ...
Petersen R C RC Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. - - 2010
We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria. We evaluated an age- and sex-stratified random sample of Olmsted County residents who were 70-89 years old on October 1, 2004, using the Clinical Dementia Rating Scale, a neurologic evaluation, and ...
Garre-Olmo J - - 2010
OBJECTIVE: To estimate the incidence of early-onset dementia (EOD) and to compare the clinical characteristics of EOD vs late-onset dementia (LOD) in a geographically defined area. METHODS: We used data from the Registry of Dementia of Girona (ReDeGi), an epidemiologic surveillance system of dementia. The ReDeGi is a standardized clinical ...
Nepal Binod - - 2010
To model impact of modifiable risk behaviour on dementia prevalence among the Australian population aged 45 years and over. A group-based computer model was constructed to estimate the impact of modifying risk behaviour on dementia prevalence. Based on population ageing, the number of people aged 45 years and over living ...
Ogunniyi Adesola A Department of Medicine, College of Medicine, University of Ibadan, Nigeria. - - 2011
The relationship between weight and dementia risk has not been investigated in populations with relatively low body mass index (BMI) such as the Yoruba. This study set out to achieve this objective using a prospective observational design. The setting was Idikan Ward in Ibadan City, Nigeria. The participants were all ...
Yusuf Abdulkareem J - - 2011
ABSTRACTBackground: Dementia has important public health implications. The magnitude of the problem remains largely unknown in the developing countries.Methods: Three hundred and twenty-two community dwelling elderly persons and their caregivers in Zaria, Northern-Nigeria were enrolled in this study. They were interviewed using Community Screening Interview for Dementia (CSI-D), Consortium to ...
Prince Martin - - 2011
ABSTRACTBackground: Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. There is a limited literature linking short legs and small skulls to an increased risk for cognitive impairment and dementia in late life.Methods: One phase cross-sectional ...
Wei Yu-Jung Jenny - - 2010
Antiparkinson drugs (APDs) are the mainstay in the management of Parkinson's disease (PD). However, the use of APDs has not been investigated in a nationally representative sample. This study aimed to describe the prevalence and patterns of APD use and to identify determinants of APD use among elderly Medicare beneficiaries ...
Luck T - - 2011
Early diagnosis of dementia requires knowledge about associated predictors. The aim of this study was to determine the impact of mild cognitive impairment (MCI) and impairment in instrumental activities of daily living (IADL) on the time to an incident dementia diagnosis.MethodData were derived from the Leipzig Longitudinal Study of the ...
Dolan David - - 2010
Recent studies suggest that dementia in the most elderly (90 years of age and above) is only modestly related to Alzheimer's disease pathology. This raises the possibility that other, as yet unknown, disease processes may underlie dementia in this rapidly growing demographic group, and that efforts designed to combat Alzheimer's ...
Verdelho A - - 2010
OBJECTIVE: We aimed to study if age-related white matter changes (WMC) and vascular risk factors were predictors of cognitive decline in elderly subjects with WMC living independently. METHODS: The Leukoaraiosis and Disability prospective multinational European study (LADIS) evaluates the impact of WMC on the transition of independent elderly subjects into ...
Sekita A - - 2010
To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population. Four cross-sectional examinations were conducted among residents of a Japanese community aged >or=65 in 1985, 1992, 1998 and 2005. The age- and sex-adjusted prevalence of all-cause dementia significantly increased with ...
Johansson Lena - - 2010
The number of people with dementia has increased dramatically with global ageing. Nevertheless, the pathogeneses of these diseases are not sufficiently understood. The present study aims to analyse the relationship between psychological stress in midlife and the development of dementia in late-life. A representative sample of females (n = 1462) ...
Lipton Richard B RB Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, - - 2010
To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). Community-based prospective cohort study. Bronx, New York. A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting ...
Kim Tae Hui - - 2010
We developed a Korean version of Mini-Mental Status Examination (MMSE) optimized for screening dementia (MMSE-DS) and its' short form (SMMSE-DS). We constructed the MMSE-DS using the items of the two current Korean versions of MMSE and then construct the SMMSE-DS consisted of 13 items from the MMSE-DS based on the ...
Zhao Qianhua - - 2010
BACKGROUND: Despite rapid development of epidemiology in dementia, reported prevalence in Asia varies among studies and differs from that of Western countries. Few reported the mortality and predictive factors on survival of dementia in Asia, especially China. METHODS: To characterize the epidemiologic pattern of dementia in Shanghai, China, including prevalence ...
Iseki Eizo - - 2010
To construct a (18)F-FDG PET normative database of Japanese healthy elderly subjects and to apply it to demented and mild cognitive impairment (MCI) patients. Seventy-seven Japanese normal volunteers from 41 to 84 years of age (36 males and 41 females) who underwent clinical, neuropsychological, and MRI examinations were selected. In ...
Saldanha D - - 2010
There has been an exponential growth in the number of elderly population in India. This study aims to determine the prevalence of dementia in an urban center of Pune and to evaluate the corresponding socio-demographic correlates along with psychiatric morbidity in the study sample. The study population in Pune and ...
Meguro Kenichi - - 2011
In 1997 we examined the prevalence of dementia among the Japanese elderly immigrants living in the São Paulo metropolitan area (n=166). Herein, we followed up on these subjects for causes of death and dementia incidence. We were able to contact 108 subjects: 54 were already dead. The most common cause ...
Mathuranath P S PS Department of Neurology, Cognition & Behavioural Neurology Section (CBNS), Trivandrum, Kerala, India. - - 2010
Data on the prevalence of dementia in India with a large and aging population is scant. We studied prevalence of AD and dementia in Kerala, South India, and effects of age, education and gender on it. 2-phase survey on 2466 individuals aged > or = 55 years living in community. ...
van Hoof J - - 2010
In Western societies, the vast majority of people with dementia live at home and wish to remain doing so for as long as possible. Aging in place can be facilitated through a variety of environmental interventions, including home modifications. This article provides an overview of existing design principles and design ...
Desai Abhilash K - - 2010
Optimal cognitive function is vital to independence, productivity, and quality of life, and the debilitation associated with dementias makes them the most feared of conditions related to aging. Effective preventive measures are key components of any response to the potentially overwhelming problem of dementias. Increasing evidence points to the potential ...
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