Search Results
Results 1 - 50 of 964
1 2 3 4 5 6 7 8 9 10 >
Stapleton Heather M HM Nicholas School of the Environment, Duke University, Durham, NC, USA. Electronic address: - - 2014
Polybrominated diphenyl ether (PBDE), flame retardants (FRs) have been ubiquitously detected at high concentrations in indoor environments; however, with their recent phase-out, more attention is being focused on measurements of exposure to alternative FRs such as organophosphate FRs (OPFRs). In our previous research, we found that PBDE residues measured on ...
Agrafiotis Michalis M 0000-0003-3563-1390 2nd Department of Intensive Care Medicine, "G. Papanikolaou" General Hospital of Thessaloniki, G. Papanikolaou Avenue, Exohi, 57010 Thessaloniki, - - 2014
Purpose. To determine the effect of each of independent acid base variables on the anion gap (AG) value in cardiac surgical patients. Methods. This retrospective study involved 128 cardiac surgical patients admitted for postoperative care. The variation of AG (AGvar) between the day of admission and the first postoperative day ...
Laine M A MA Institute of Dentistry, University of Turku, FI-20520 Turku, Finland. Electronic address: - - 2014
The aim was to study the impact of dietary intervention on the properties of paraffin-stimulated saliva, and on dental caries. At 7 months of age 1062 infants (540 intervention; 522 controls) started in the prospective, randomized Special Turku Intervention Project (STRIP) aimed at restricting the child's saturated fat and cholesterol ...
Berman T - - 2013
Exposure to organophosphate pesticides (OPs) in agricultural and urban populations has been associated with a range of adverse health effects. The purpose of the current study was to estimate exposure to OPs in the general adult population in Israel and to determine dietary and demographic predictors of exposure. We measured ...
Zur Loye Hanno - - 2013
Duward F. Shriver passed away at the age of 78 on March 6, 2013. He was well-known to generations of inorganic and organometallic chemists from his classic textbooks.
McTeer Jennifer - - 2013
Abstract This study assessed the bioavailability, toxicity and transfer of silver nanoparticles (AgNPs) in comparison with AgNO3 in two model food chain organisms; the alga Chlamydomonas reinhardtii and the grazing crustacean Daphnia magna. The effects of phosphate, a potential Ag+ binding ligand and a determinant of phytoplankton productivity, were evaluated. ...
Yasin Abeer - - 2013
ABSTRACT: BACKGROUND: Fibroblast growth factor-23 (FGF-23), a novel marker of bone disease in chronic kidney disease (CKD) has been shown to correlate with vascular calcifications. We aimed to describe the effect of the calcium phosphate product (Ca*P) on FGF-23 concentrations in children and young adults without confounding cardiovascular disease. METHODS: ...
Harper Julie C - - 2012
Objective: There is an increasing interest in gender differences both in the pathogenesis and treatment of skin diseases. We investigate whether there were any treatment differences in male and female subjects treated with clindamycin phosphate 1.2%/benzoyl peroxide (BPO) 2.5% gel as monotherapy for moderate to severe acne. Methods: We performed ...
Srebońćan Emil - - 2012
Concentrations of cadmium, lead and mercury were determined in muscle, liver and kidney tissue from three different age groups of red deer (young animals aged 6 or 7 months, middle-aged animals aged 3 to 5 years, old animals aged over 8 years) from the Baranja region of Croatia. Median cadmium concentrations were ...
Sung Young-Hoon YH Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. - - 2013
Mitochondria-related mechanisms have been suggested to mediate methamphetamine (METH) toxicity. However, changes in brain energetics associated with high-energy phosphate metabolism have not been investigated in METH users. Phosphorus-31 ((31)P) magnetic resonance spectroscopy (MRS) was used to evaluate changes in mitochondrial high energy phosphates, including phosphocreatine (PCr) and β-nucleoside triphosphate (β-NTP, ...
Ferlitsch Monika - - 2012
von Willebrand factor antigen (vWF-Ag) is elevated in patients with liver cirrhosis, but the clinical significance is unclear. We hypothesized that vWF-Ag levels may correlate with portal pressure, measured by hepatic venous pressure gradient (HVPG), and predict clinically significant portal hypertension (CSPH; HVPG ≥ 10 mmHg), decompensation and mortality. Portal ...
Verma Suman S Division of Gastroenterology & Hepatology, University Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United - - 2012
Telomeres, a validated biomarker of aging, comprise multiple nucleotide repeats capping chromosomes that shorten with each cell cycle until a critical length is achieved, precipitating cell senescence. Only two previous studies focused on the effect of aging in "normal" liver tissue, but these studies were compromised by small sample size, ...
Li Xiaoming - - 2012
BACKGROUND: Nonalcoholic fatty liver disease is closely associated with metabolic syndrome and cardiovascular disease (CVD). We investigated whether the liver fat content (LFC) is independently associated with carotid artery intima-media thickness (CIMT) and evaluated the contribution of the LFC to the increased CIMT. METHODS: We conducted a community-based study among ...
Gagné F - - 2012
A simple, rapid and inexpensive screening test is presented to determine the presence of silver (Ag) nanoparticles in biological samples. The method is based on graphite furnace-atomic absorption spectrometry (Zeeman background correction) where an increase in the atomization temperature is observed with an increase in the particle size of Ag. ...
Kjartansdottir Ingibjörg - - 2012
Abstract Objective. Paracetamol is the most common cause of acute liver failure (ALF) in many countries. Much data on paracetamol toxicity originate from liver transplant centers and tertiary referral institutions. The authors analyzed the population-based annual incidence of paracetamol overdoses and ALF, and described the risk factors for hepatotoxicity. Methods. ...
Feldman R D - - 2012
Abstract Objectives: To compare the simultaneous reduction of blood pressure (BP) to below 150 mmHg and low-density lipoprotein cholesterol (LDL-C) after treatment with single-pill amlodipine/atorvastatin (SPAA) among younger (<65 years), older (≥65 years) and elderly (≥75 years) men and women with hypertension and dyslipidemia. Methods: Data from five, 14 to ...
Jaffer O S - - 2012
To assess the inter- and intra-observer variability of acoustic radiation force impulse (ARFI) quantification in liver segments with influence of age, body mass index (BMI) and liver capsule-to-box (CB) distance. 10 healthy volunteers were examined twice, by three experienced operators, separated by a 1-week interval. 10 readings were obtained, from ...
Mochizuki Kazuki - - 2012
PURPOSE: Elevated circulating activities of alanine aminotransferase (ALT), a marker for liver injury, and the lifestyle of a higher rate of eating in healthy and preclinical subjects are associated with increased risk of obesity and diabetes. In this study, we examined the associations between self-reported rate of eating and circulating ...
Franzini Maria - - 2012
BACKGROUND: Four fractions of gamma-glutamyltransferase (GGT) with different molecular weight (b-, m-, s-, and f-GGT) are present in human plasma. Differential GGT fraction pattern is found in non-alcoholic liver disease (NAFLD) and chronic viral hepatitis, characterized by normal or decreased b-GGT/s-GGT (b/s) ratio, respectively. METHODS: Chromatographic fractional GGT analysis was ...
Park Seung Ha - - 2012
OBJECTIVES:: For the pediatric population, upper reference limits (URLs) for aminotransferase levels have not been established. The prevalence of high aminotransferase levels provides important information regarding the burden of liver disease in the current childhood obesity endemic. STUDY DESIGN:: We set the URL of alanine aminotransferase (ALT) and aspartate aminotransferase ...
Kritikou I - - 2012
In obese males visceral adiposity has been associated with obstructive sleep apnoea (OSA), while studies in overweight males and females are limited. Our goal was to examine the association between OSA and visceral fat in a relatively non-obese population and assess the effects of a 2month placebo-controlled CPAP use on ...
Tandon Puneeta - - 2012
Severe muscle depletion, termed sarcopenia, as detected by cross-sectional imaging, holds promise for prognostication in patients with cirrhosis. Our aims were to describe the prevalence and predictors of sarcopenia in cirrhotic patients listed for liver transplantation (LT) and determine its independent prognostic significance for the prediction of waiting list mortality. ...
Park Seung Ha - - 2012
BACKGROUND: Trends in hepatitis B virus (HBV) infection are important in evaluating the effectiveness of the recommended routine vaccination of infants and adolescents. METHODS: The prevalence of HBV infection was determined in a representative sample of the Korea National Health and Nutrition Examination Survey for 1998 (n=9771) and 2009 (n=8304). ...
Chen Jun - - 2012
BACKGROUND: Recent studies suggest that the storage age of red blood cells (RBCs) may be associated with morbidity and mortality in surgical patients. We studied perioperative effects of RBC storage age in patients undergoing orthotopic liver transplant (OLT). METHODS: Adult patients who received ≥5 U of RBCs during OLT between January ...
Kosla Tadeusz - - 2012
The European bison (Bison bonasus) is the only living species of the bison genus in the Old World. It is the largest, wild, herbivorous mammal living in Europe. As a result of the efforts of biologists, the European bison has been saved as a species. In Poland, they were reintroduced ...
Zhu Y - - 2012
SUMMARYThis study aimed to determine current seroprevalence of hepatitis A virus (HAV) antibody in subjects aged 0-30 years in Shanghai. A total of 5515 subjects were recruited through random clustering sampling in 2009. Basic clinical and demographic information and records of HAV vaccination were acquired by questionnaire interviews and review ...
Guimarães Diana - - 2012
The concentration of lead in liver and kidneys of Wistar rats, fed with lead since fetal period in relation to their age and to a control group, was determined. A group of rats was exposed to lead acetate (n=30) in drinking water and the other group was exposed to normal ...
Campagna Marcello - - 2012
Continuous assessment of hepatitis A virus (HAV) seroepidemiology is a useful tool to control the risk of infection. This study aimed to evaluate the changing patterns of anti-HAV seroprevalence in a population,which isgenerally considered to be anarea ofhigh endemicity. Overall, the results of 3349 sera collected during the period 2005-2008 ...
Khoo E Y H - - 2012
BACKGROUND: Hyperalimentation for 4 weeks is associated with raised liver enzymes and liver fat content (LFC), which are two common features found in individuals with diabetes. AIM: We evaluated the effect of two mixed meal challenges on LFC, liver enzymes and serum bio-markers of liver injury and fibrosis in 16 healthy ...
Frith James J UK National Institute for Health Research, Biomedical Research Centre in Ageing-Liver Theme, Newcastle University, Newcastle, NE1 7RU, UK. - - 2012
Improved survival with chronic liver disease (CLD) and increased incidence in the older has led to a rapidly expanding population which faces similar "geriatric syndromes" as the general population. With risk factors such as autonomic dysfunction, cognitive impairment, and muscle abnormalities in CLD it is expected that falls and injury ...
Hashemi Mohammad - - 2012
BACKGROUND: The aim of the study was to investigate paraoxonase-1 (PON1) and aryl esterase (ARE) activities in patients with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: This case-control study was done on 83 subjects with confirmed NAFLD (50 male, 33 female, age; 40.46±12.13 years) and 138 healthy individuals (75 ...
Helmy Mai M - - 2012
Background: The effect of α-tocopherol or simvastatin treatment on antioxidant defense in liver of old rats was investigated. Methods: Endogenous thiobarbituric acid reactive substances (TBARS) and total nitrite/nitrate (NO(2)/NO(3)) levels as well as non-enzymatic glutathione (GSH) and enzymatic antioxidants [glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) ...
Hoshyari Ebrahim - - 2012
The objective of the present study was to investigate the levels of metals, namely cadmium, lead, and zinc, in Siberian gull (Larus heuglini) (n = 15), in order to: (1) examine the sex and gender related variation in trace metal accumulation, and (2) to determine the significant between metal concentrations in the ...
Gramenzi Annagiulia - - 2012
BACKGROUND: The prevalence of hepatitis C virus infection increases with advancing age, but elderly hepatitis C virus patients remain an understudied population. AIM: To define the virological, epidemiological and clinical profiles of Italian outpatients aged 65 years and over infected by hepatitis C virus. METHODS: We evaluated 1544 anti-hepatitis C ...
Lee Kang-Hoon - - 2012
We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain retroelements. In addition, there ...
Uemura Tadahiro - - 2012
Advanced age donors have inferior outcomes of liver transplantation for Hepatitis C (HCV). Aged donors grafts may be transplanted into young or low model for end stage liver disease (MELD) patients in order to offset the effect of donor age. However, it is not well understood how to utilize liver ...
Miyagi Shogo J - - 2012
This article reports on the development of UDP-glucuronosyltransferase 1A9 (UGT1A9) in neonatal and pediatric liver. The substrate 4-methylumbelliferone (4MU) with specific inhibition by niflumic acid was used to define specific UGT1A9 activity. Subsequently, in silico pharmacokinetic (PK) and physiology-based pharmacokinetic (PBPK) modeling was used to determine UGT1A9 maturation and hepatic ...
Hanada Shinichiro - - 2012
Mallory-Denk bodies (MDBs) are hepatocyte cytoplasmic inclusions found in several liver diseases and consist primarily of the cytoskeletal proteins, keratins 8 and 18 (K8/K18). Recent evidence indicates that the extent of stress-induced protein misfolding, a K8>K18 overexpression state, and transglutaminase-2 activation promote MDB formation. In addition, the genetic background and ...
Fu Zidong Donna - - 2012
Aging is a physiological process characterized by progressive functional decline in various organs over time. To reveal possible molecular mechanisms of altered xenobiotic disposition and toxicity in elderly individuals, age-dependent mRNA profiles for 101 xenobiotic-processing genes (XPGs), including seven uptake transporters, 41 phase I enzymes, 36 phase II enzymes, 10 ...
Palou Mariona - - 2012
We aimed to assess the mechanisms responsible for hyperphagia and metabolic alterations caused by maternal moderate caloric restriction during gestation. Male and female offspring of control and 20% caloric-restricted rats (CR) were studied. They were fed a normal-fat diet until 4 months of age and then moved to a high-fat ...
Chung Goh Eun - - 2012
The aim of this study was to characterize the relationship between the broad spectrum of hypothyroidism and NAFLD. A cross-sectional study with 4648 health check-up subjects (2324 cases with hypothyroidism vs. age- and sex-matched controls) was conducted. The subjects were categorized as having either subclinical [thyroid-stimulating hormone (TSH) ≥4.1 mIU/L ...
Sutton Gregory M GM Protein Deficiency and Developmental Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA. - - 2013
Biological aging alters the metabolism and volume of adipose tissue depots. Recent evidence suggests that circadian mechanisms play a role in promoting adipogenesis, obesity, and lipodystrophy. The current study compared cohorts of younger (5-9 months) and older (24-28 months) C57BL/6 mice as a function of biological age and circadian time. ...
Son Nari - - 2012
We used UPLC-Q-TOF MS to analyze hepatic metabolites of rats aged 6, 12, 18, and 24 months; the MS data were processed by partial least-squares discriminant analysis (PLS-DA) to investigate the discrimination among sample groups. Rats were significantly separated with increasing age, except those aged between 6 and 12 months. ...
Shim J J - - 2012
SUMMARYKorea has recently experienced an increasing number of acute hepatitis A cases. We investigated the dynamics of hepatitis A and changes in the mean age of patients in a hospital in Seoul, Korea. Mean age increased consistently from 19 years in 1996 to 30 years in 2009 (P<0·0001). Between two ...
Eguchi Yuichiro - - 2012
BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the prevalence of nonalcoholic steatohepatitis (NASH) with liver fibrosis using established scoring systems in the general population. METHODS: A cross-sectional study was conducted among 8352 ...
Lee Kayoung - - 2012
This study assessed the association between vitamin D sufficiency (serum 25(OH)D ≥30 ng/mL) and alcohol consumption using data from the Korea National Health and Nutrition Examination Survey conducted in 2009. The following characteristics were obtained in 7,010 Korean participants ≥19-years-of-age: serum 25(OH)D level, alcohol consumption (drinking frequency, drinking number of ...
Huber Sandra - - 2012
Long-term temporal trends (1991-2008) and spatial differences of perfluoroalkylated substances (PFASs) were investigated in harbor porpoise (Phocoena phocoena) liver samples of juvenile females from the Baltic and North Sea. Additionally, spatial differences between the populations in the Baltic Sea and Atlantic Ocean (i.e. Iceland and Norway) and the influence of ...
Hiyoshi Mineyoshi - - 2012
In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol-O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to ...
Maio Sara - - 2012
In order to raise public awareness of the importance of early detection of airway obstruction and to enable many people who had not been tested previously to have their lung function measured, the European Lung Foundation and the European Respiratory Society (ERS) organised a spirometry testing tent during the annual ...
Decman Vilma - - 2012
Aging is associated with suboptimal CD8 T cell responses to viral infections. It is not clear whether these poor responses are due to environmental influences or quantitative and qualitative changes in the pool of responding CD8 T cells. Our studies demonstrated several deleterious age-related changes in the pool of Ag-specific ...
1 2 3 4 5 6 7 8 9 10 >