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Gratz Iris K IK Department of Dermatology, University of California San Francisco, San Francisco, CA - - 2014
Immune homeostasis in peripheral tissues is achieved by maintaining a balance between pathogenic effector T cells (Teffs) and protective Foxp3(+) regulatory T cells (Tregs). Using a mouse model of an inducible tissue Ag, we demonstrate that Ag persistence is a major determinant of the relative frequencies of Teffs and Tregs. ...
Rtimi S - - 2013
This study reports the design, preparation, testing and surface characterization of uniform films deposited by sputtering Ag and Ta on non-heat resistant polyester to evaluate the Escherichia coli inactivation by TaON, TaN/Ag, Ag and TaON/Ag polyester. Co-sputtering for 120s Ta and Ag in the presence of N2 and O2 led ...
Alves Markênia Kélia Santos - - 2013
CDKN2A promoter hypermethylation has been widely related to many cancers. In astrocytomas, although CDKN2A (p16(INK4A) protein) is often inactivated, there are still some controversial issues regarding the mechanism by which this alteration occurs. Thus, we analyzed a series of astrocytomas to assess the association between CDKN2A expression and methylation of ...
Jin Jung Kyung - - 2013
The molecular inflammation hypothesis of aging proposes that redox dysregulation causes an age-related activation of NF-κB and its signaling to upregulate various proinflammatory genes. In the present study, we focused on the inactive form of the protein phosphastase 2A (PP2A). More specifically, we aimed to define the correlation between PP2A ...
Godler David E DE Cyto-molecular Diagnostic Research Laboratory, Victorian Clinical Genetics Services and Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Victoria 3052, Australia. - - 2013
Methylation of the fragile X-related epigenetic element 2 (FREE2) located on the exon 1/intron 1 boundary of the FMR1 gene is related to FMRP expression and cognitive impairment in full mutation (FM; CGG>200) individuals. We examined the relationship between age, the size of the FMR1 CGG expansion and the methylation ...
Su Rina - - 2012
The objective of this study was to determine the bactericidal mechanisms of Ag-doped multi-walled carbon nanotube (MWCNT) nanoparticles (Ag(0)/MWCNTs) to Escherichia coli DH5α. The contributions of silver ion dissolution, reactive species, and direct contact on bacteria inactivation were systematically determined. The relatively higher survival rate of bacteria exposed to 0.02mgL(-1) ...
Cumurcu Tongabay - - 2012
PURPOSE: To evaluate the tear film function and ocular surface changes in heavily drinking men. METHODS: This prospective case-control study involved 35 male subjects with heavy alcohol consumption (group 1) and 35 age- and sex-matched control subjects (group 2). Best-corrected visual acuity measurement, slit-lamp examination, Schirmer I test, tear film ...
Ventura Maria Teresa - - 2012
The constant increase in the elderly population worldwide has led to a greater interest in immunologic responses during aging. Thus, special attention to allergic diseases in elderly people has begun to emerge, but little is known about the effect and features of allergic rhinitis in elderly people. To evaluate the ...
Xue Xia - - 2012
The whitefly Bemisia tabaci is cryptic species complex composed of numerous species. Individual species from the complex harbor a diversity of bacterial endosymbionts including Wolbachia. However, while Wolbachia is known to have a number of different roles, its role in B. tabaci is unclear. Here, the antibiotic rifampicin is used ...
Atalay Sacide - - 2012
We aimed to investigate the diagnostic utility of osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and alkaline phosphatase (ALP) in pre- and postmenopausal women for femoral neck, L1-4, and L2-4 bone mineral density (BMD) values by taking into consideration their age, body mass index (BMI), and menopausal status. Premenopausal (N=40) and postmenopausal ...
Marwaha Raman K - - 2011
We undertook this study to establish age-specified bone mineral density (BMD) reference range for Indian females using dual-energy X-ray absorptiometry. BMD at multiple skeletal sites was measured in 2034 healthy women aged 18-85yr. The effect of anthropometry and biochemical parameters on BMD was determined. Peak BMD was observed between 30 ...
Sun Yue - - 2011
Autosomal dominant hypophosphatemic rickets (ADHR; MIM 193100) is a hereditary disorder characterized by isolated renal phosphate wasting, hypophosphatemia, and inappropriately normal 1,25-dihydroxyvitamin D(3) levels. Recent studies have shown that the fibroblast growth factor 23 (FGF23) gene is responsible for this disease. FGF23 protein is a phosphaturic factor that is elevated ...
Perinetti Giuseppe - - 2011
Identification of skeletal maturation phases is of primary importance in terms of individual responsiveness to nearly all dentofacial orthopaedic treatments. In this regard, dentition phase and chronological age are still widely used to define the timing of and responsiveness to orthodontic treatments. Recently, gingival crevicular fluid (GCF) alkaline phosphatase (ALP) ...
Wong R W K - - 2011
Preliminary results were determined for a database on 3-dimensional (3D) cephalometrics using McNamara's analysis in an adult southern Chinese population based on cone-beam computerized tomography (CBCT). 3D dentoskeletal morphology was assessed from CBCTs from 80 (39 males; 41 females; 21-30 years) consecutive adult southern Chinese without gross craniofacial deformity or ...
Chen Wei-Yu - - 2011
The purpose of this study was to link toxicokinetics/toxicodynamics and subcellular partitioning for assessing the susceptibility and the growth inhibition risks of abalone Haliotis diversicolor supertexta exposed to waterborne and foodborne cadmium (Cd) and silver (Ag). We reanalyzed published data on growth inhibition and subcellular partitioning associated with the present ...
Agusa Tetsuro - - 2011
Body distribution and growth- and nutritional status-dependent accumulation of 21 trace elements were investigated in harbor seals (Phoca vitulina) stranded in the North Sea coast in 2002. Higher concentrations and burdens of Mn, Se, Mo, Ag, Sn, Hg, and Bi in the liver, Cd in the kidney, As in the ...
Storr Helen L - - 2011
Objective: There are few published comparisons between paediatric and adult-onset Cushing's disease (CD). We compare the epidemiology, diagnostic features and cure rate by transsphenoidal surgery (TSS) in these groups. Design: Retrospective review of patient databases in single university hospital centre. Patients: Forty-one paediatric (mean age 12.3±3.5 yr; range 5.7-17.8) and ...
Manteca Xavier - - 2011
With increasing age, some dogs develop a neurogenerative disease that is commonly referred to as canine cognitive dysfunction syndrome (CDS). Diagnosis of CDS can be clinical or based on laboratory tests. The main behavioral changes associated with CDS are disorientation, altered interactions with people or other animals, sleep-wake cycle alterations, ...
Gupta Neera - - 2011
Growth impairment in Crohn's disease (CD) is more common in males than females for unknown reasons. Since insulin-like growth factor-1 (IGF-1) is important for statural growth, we hypothesized that IGF-1 levels are lower in males with CD. Sex differences in hormone Z-scores based on chronological age (CA-Z) and bone age ...
Mangat Birinder K BK Department of Medicine, University of British Columbia, Vancouver, British - - 2011
There is currently little available information regarding the impact of ethnicity on the clinical features of inflammatory bowel disease (IBD). Migrating populations and changing demographics in Vancouver, British Columbia (BC) provide a unique opportunity to examine the role of ethnicity in the prevalence, expression and complications of IBD. To determine ...
Devaney Joseph M JM Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children’s National Medical Center, 111 Michigan Ave. NW, Washington, DC 20010, - - 2011
Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin,insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. We hypothesized that AKT1 variants may play a role in the endophenotypes ...
Hipfner J M - - 2011
In 2003 and 2004, we measured mercury concentrations and δ(15)N and δ(13)C values in the whole blood of adults of two species of seabirds, Cassin's auklet (Ptychoramphus aleuticus) and rhinoceros auklet (Cerorhinca monocerata), during their prelaying, incubation, and provisioning periods. We also collected whole blood from the offspring of both ...
Ferrari M - - 2011
To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities. Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF<15 μg/l). Iron deficiency (ID) was defined as high-soluble transferrin receptor (sTfR>8.5 mg/l) plus ...
Pansuwan Anupong - - 2011
The prevalence of adolescent anemia, iron deficiency and thalassemia were examined in 2 provinces of northeast Thailand. Blood specimens were collected from adolescent subjects aged 15-17 years in 2 areas; 185 (85 males and 100 females) in Mukdahan province and 313 (116 males and 197 females) in Roi-Et. RBC parameters, ...
Hermoso de Mendoza García María - - 2011
In the present study, bioaccumulation of lead, cadmium and zinc in liver, kidney and muscle of roe deer (Capreolus capreolus) from Galicia (NW Spain) was quantified. Metal analysis was performed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In general the quantified concentrations were associated with background environmental levels, except for ...
Rajput A H - - 2011
Most of the literature on pathology of essential tremor (ET) has reported no consistent abnormalities. Some recent studies however indicate that cerebellar Purkinje cell (PC) loss is the pathological basis of ET in most patients. To compare cerebellar PC loss in ET, with normal and tremor dominant Parkinson's disease [PD] ...
Pereira Thalita Cremonesi - - 2011
Zinc deficiency in children and adolescents impairs their growing, development and immune system. To verify the existence of plasma and leukocyte zinc deficiency in adolescents with autoimmune hepatitis. The study comprised 23 patients with autoimmune hepatitis, aged 10-18 years, assisted at the Ambulatory Service of Pediatric Hepatology of the University ...
Dexheimer Verena - - 2011
Mesenchymal stem cells (MSC) are promising for cell-based regeneration therapies but up to date it is still controversial whether their function is maintained throughout ageing. Aim of this study was to address whether frequency, activation in vitro, replicative function, and in vitro lineage choice of MSC is maintained throughout ageing ...
Blasiak Janusz - - 2011
Reactive oxygen species (ROS) may contribute to the pathogenesis of age-related macular degeneration (AMD) and they can be produced in the Fenton reaction catalyzed by Fe3+ ions. Therefore, altered homeostasis of iron in the retina may be the source of ROS and its damage resulting in clinically detectable AMD symptoms. ...
Malcolm Charlotte P - - 2010
BACKGROUND: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population ...
Shin Minah - - 2011
An association between cadmium exposure and bone mineral density (BMD) has been demonstrated in elderly women, but has not been well studied in youths and men. Some studies report either no or a weak association between cadmium exposure and bone damage. This study was designed to investigate the relationship between ...
Vincenzi Simone - - 2011
To understand the consequences of the invasion of the nonnative rainbow trout Oncorhynchus mykiss on the native marble trout Salmo marmoratus, we compared two distinct headwater sectors where marble trout occur in allopatry (MTa) or sympatry (MTs) with rainbow trout (RTs) in the Idrijca River (Slovenia). Using data from field ...
San Luciano Marta M Department of Neurology, Beth Israel Medical Center, New York, New York, USA. - - 2010
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2, PARK8) are the most commonly identified monogenic etiology of Parkinson disease (PD). Over-represented in the Ashkenazi Jewish population, these mutations are transmitted in an autosomal dominant manner with age-dependent reduced penetrance. The natural history and penetrance of these mutations in the ...
Nederhof E - - 2010
The purpose was to study how functional polymorphisms in the brain derived neurotrophic factor gene (BDNF val66met) and the serotonin transporter gene linked promotor region (5-HTTLPR) interact with childhood adversities in predicting Effortful Control. Effortful Control refers to the ability to regulate behavior in a goal-directed manner and is an ...
Jacobsen Rune - - 2010
Studies of Nordic twins suggest an increased genetic influence on mortality with age. Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals carrying a 'frail' or 'risky' genotype in a population will approach that of noncarriers with age because of selection pressure. The ApoE ε4 allele is ...
Akra-Ismail Maya - - 2010
several studies have looked at the potential link between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the risk of hypertension and have shown that the DD polymorphism may be associated with a higher prevalence of hypertension. Our objective was to assess for possible association between ACE variants and hypertension in ...
Chittleborough Catherine R - - 2011
To examine associations between psychological distress (PD) and chronic health conditions among different age groups in a representative population sample. PD measured by the Kessler-10, and the presence of diagnosed chronic conditions were self-reported by respondents aged 18 years and over in a South Australian continuous computer-assisted telephone interviewing surveillance system ...
Lee M S - - 2011
Lee MS, Lyoo CH, Ryu YH, Lim HS, Nam CM, Kim HS, Rinne JO. The effect of age on motor deficits and cerebral glucose metabolism of Parkinson's disease. Acta Neurol Scand: 2011: 124: 196-201. © 2010 John Wiley & Sons A/S. Background -  No systematic study has been made to separate ...
Jawaid A - - 2011
Background:  The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (ALS). Methods:  ...
Polosak Jacek - - 2011
The WRN gene encodes DNA helicase participating in genome maintenance. We looked for associations of natural aging with expression and methylation of this gene in blood mononuclear cells and with its common polymorphisms. Analyses were performed in ethnically homogenous Polish Caucasians. The mean level of the WRN messenger RNA was ...
Yamamoto-Watanabe Yukiko - - 2010
Cystatin C (CC) is a cysteine protease inhibitor abundantly expressed in the central nervous system. Bunina bodies, small eosinophilic intraneuronal inclusions, are stain positive for CC and are the most specific histological hallmark of amyotrophic lateral sclerosis (ALS). In this study, employing a latex turbidimetric immunoassay, levels of CC in ...
Ritchie C W - - 2011
ABSTRACTBackground: Suicide rates are higher in the over 65s than in younger adults and there is a strong link between deliberate self harm (DSH) and suicide in older people. The association between personality disorder (PD) and DSH in older adults remains uncertain. Our objective was to describe this association.Methods: A ...
Panizzon M S - - 2010
The APOE epsilon4 allele is an established risk factor for Alzheimer disease (AD), yet findings are mixed for how early its effects are manifest. One reason for the mixed results could be the presence of interaction effects with other AD risk factors. Increasing evidence indicates that testosterone may play a ...
Heise V V Department of Psychiatry, University of Oxford, Oxford, - - 2011
The Apolipoprotein E (APOE) ɛ4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is also associated with structural gray matter and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, ...
Corbo Rosa Maria - - 2011
Aromatase (CYP19) and estrogen receptor-alpha (ESR1) are involved in the metabolism of estrogens, which have a relevant role in female and male aging. Moreover, due to their influence on fertility, both genes may be part of the longevity-fertility trade-off mechanism. This investigation examines the association of ESR1 (PvuII and XbaI) ...
Yerpude Pravin N - - 2010
To study the morbidity pattern among cotton mill workers. This cross-sectional study was conducted in cotton mills in Guntur District (AP) in January 2009 to May 2009. Total 474 workers were included in the study. All study subjects were male. Most of the study subjects belonged to age group 30-40 ...
Wong Ka Kit - - 2010
Olfactory dysfunction may precede common neurodegenerative disorders in the elderly, such as Alzheimer (AD) or Parkinson disease (PD). However, pathobiological mechanisms of olfactory loss in the elderly are poorly understood. Although nigrostriatal dopaminergic denervation is a key patholobiological feature of PD, age-associated nigrostriatal denervation (AASDD) occurs also with normal aging ...
Abbott Robert D - - 2012
Brain iron promotes neurodegeneration in Parkinson's disease (PD). While hemoglobin (Hb) is the most abundant source of peripheral iron in humans, its relationship with PD is uncertain. This report examines the association between Hb in late life and PD incidence. From 1991 to 1993, Hb was measured in 3507 men ...
Zheng Zhaoliang - - 2010
Pd and Pd-Ag bimetallic defect-rich nanocrystals were synthesized with iodobenzene as capping agent, followed by post-treatment with ice-cooled acetone.
Filippini N N University Department of Psychiatry, University of Oxford, Oxford, - - 2011
Increasing age and carrying an APOE ε4 allele are well established risk factors for Alzheimer's disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an accelerated aging process. We recently reported that APOE genotype modulates brain function decades before the appearance of any cognitive or ...
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