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Doney Brent B 1Division of Repiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown, WV , - - 2014
Abstract Background: The study evaluated the change in the prevalence of airflow obstruction in the U.S. population 40-79 years of age from years 1988-1994 to 2007-2010. Methods: Spirometry data from two representative samples of the U.S. population, the National Health and Nutrition Examination Surveys (NHANES) conducted in 1988-1994 and 2007-2010, were ...
Cheng Shaokoon S Neuroscience Research Australia, Sydney School of Medical Science, UNSW - - 2014
A patent upper airway is essential for survival. Increased age, obesity and some upper airway anatomical features are associated with failure to maintain upper airway patency during sleep, leading to obstructive sleep apnoea. However, many healthy subjects with these risk factors do not develop this condition. The aim of this ...
Zhu D D Department of Cardiology, Peking University Third Hospital, 49 Huayuan-Bei Road, Beijing, 100191, - - 2014
This paper explores age- and gender-specific changes in Doppler echocardiographic index-E' of left ventricular diastolic function. The study involved 366 hypertensive patients (197 men and 169 women) who were aged from 20 to 90 years (mean 58.60 ± 15.68 years), without a diagnosis of any other disease. Early diastolic mitral inflow velocity (E), late ...
Tsai Wen-Chin WC Division of Cardiology, Tzu-Chi General Hospital, Hualien, - - 2014
Aging and testosterone deficiency contribute to the pathogenesis of atrial fibrillation (AF). We determine the effects of testosterone replacement on the electrophysiology and arrhythmogenesis of pulmonary vein (PV) and left atrium (LA) in aged rabbits. Electrocardiography, heart rate variability, echocardiography, Western blot and conventional microelectrodes were used in aged rabbits ...
Salminen Lauren E LE Department of Psychology, University of Missouri-Saint Louis, 1 University Boulevard, Stadler Hall 442 A, St. Louis, MO, 63121, USA, - - 2014
Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact ...
Beckett Nigel N aImperial College London, Faculty of Medicine, London, UK bMedical University of Milano, Cardiovascular Rehabilitation and Cardiac Disease Unit, Milan, Italy cMater Hospital, Dublin, Ireland dHypertension & Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Belgium eDepartment Hypertension and Diabetology, Meical University of Gdansk, Poland fWhitby Group Practice, Whitby gLondon School of Hygiene and Tropical Medicine, London, UK *All committee members and investigators are listed in the On-line - - 2014
The results of the Hypertension in the Very Elderly Trial showed positive benefits from blood pressure-lowering treatment in those aged 80 and over. An analysis by the pre-specified subgroups [age, sex, history of cardiovascular disease (CVD) and initial SBP] was performed. The Hypertension in the Very Elderly Trial was a ...
Ianhez Mayra M Hospital das clínicas (Dermatology Department), Universidade Federal de Goiás, UFG, 1a avenida, qd 68 lt AR 1-, Setor Leste Universitário, Goiânia, Goiás CEP: 74605-020, Brazil. Electronic address: - - 2014
Cryosurgery with liquid nitrogen is one of the most used treatments for actinic keratosis. We aimed to study the effectiveness of two consecutive sessions of cryosurgery for actinic keratosis and investigate factors associated with its therapeutic success. Hence, we conducted a longitudinal study including 92 patients of both sexes, aged ...
Sueta Daisuke D Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, - - 2014
Elderly hypertensive patients are characterized by blood pressure (BP) variability, impaired autonomic function, and vascular endothelial dysfunction and stiffness. However, the mechanisms causing these conditions are unclear. The present study examined the effect of angiotensin receptor blockers (ARBs) on aged spontaneously hypertensive rats (SHR). We surgically implanted telemetry devices in ...
Rumball-Smith Juliet - - 2014
There is growing evidence to suggest unemployment has a role in the development and incidence of cardiovascular disease. This study explores the contribution of breaks in employment to the development of hypertension, a key risk factor for coronary heart disease. We use data from the Survey of Health, Ageing, and ...
Egan Brent M BM University of South Carolina School of Medicine & Greenville Health System, Care Coordination Institute, Greenville, - - 2014
Joint National Committee goal blood pressure (BP) for all adults was <140/<90 mmHg or lower from 1984 to 2013. Adults ≥60 years (older) have mainly isolated systolic hypertension (ISH) with major trials attaining systolic BP <150 but not <140. The main objective was to assess changes in hypertension control to ...
Nilsson Peter M PM Department of Clinical Sciences, Lund University, Skane University Hospital, - - 2014
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into ...
Brown Jenifer M JM Division of Endocrinology, Diabetes, and - - 2014
Aging and abnormal aldosterone regulation are both associated with vascular disease. We hypothesized that aldosterone dysregulation influences the age-related risk of renal vascular and cardiovascular disease. We conducted an analysis of 562 subjects who underwent detailed investigations under conditions of liberal and restricted dietary sodium intake (1124 visits) in the ...
Kiyota Tatiana A TA Department of Internal Medicine, School of Medical Sciences, State University of Campinas, São Paulo, - - 2014
Hypertensive patients exhibit higher cardiovascular risk and reduced lung function compared with the general population. Whether this association stems from the coexistence of two highly prevalent diseases or from direct or indirect links of pathophysiological mechanisms is presently unclear. This study investigated the association between lung function and carotid features ...
Tuppin Philippe P Caisse Nationale d'Assurance Maladie des Travailleurs Salariés (CNAMTS), Paris, France. Electronic address: - - 2014
National population-based management and outcome data for patients of all ages hospitalized for heart failure have rarely been reported. National population-based management and outcome of patients of all ages hospitalized for heart failure have rarely been reported. The present study reports these results, based on 77% of the French population, ...
Perkiömäki Juha J Medical Research Center, University of Oulu, Oulu, Finland; University Hospital of Oulu, - - 2014
Autonomic nervous system modifies atrial electrophysiologic properties and arrhythmia vulnerability. Heart rate (HR) variability, an indicator of cardiac autonomic regulation, was measured in 784 subjects (mean age 51±6 years, 54% males) from a standardized 45-minute period in a study population (n = 1,045), which consisted of randomly selected hypertensive and ...
Mellor Kimberley M KM Department of Physiology, University of Melbourne, Melbourne, VIC, Australia, - - 2014
Clinically, heart failure is an age-dependent pathological phenomenon and displays sex-specific characteristics. The renin-angiotensin system mediates cardiac pathology in heart failure. This study investigated the sexually dimorphic functional effects of ageing combined with angiotensin II (AngII) on cardiac muscle cell function, twitch and Ca(2+)-handling characteristics of isolated cardiomyocytes from young ...
Teng Tiew-Hwa Katherine TH Combined Universities Centre for Rural Health, University of Western Australia, Australia. Electronic address: - - 2014
To compare the incidence of first heart failure (HF) hospitalisation, antecedent risk factors and 1-year mortality between Aboriginal and non-Aboriginal populations in Western Australia (2000-2009). A population-based cohort aged 20-84years comprising Aboriginal (n=1013; mean 54±14years) and non-Aboriginal patients (n=16,366; mean 71±11years) with first HF hospitalisation was evaluated. Age and sex-specific ...
Shan Haiyan H Department of Gerontology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, - - 2014
Angiotensin II (Ang II) plays important roles in ageing-related disorders through its type 1 receptor (AT1 R). However, the role and underlying mechanisms of AT1R in ageing-related vascular degeneration are not well understood. In this study, 40 ageing rats were randomly divided into two groups: ageing group which received no ...
Jefferson Angela L AL Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, 2525 West End Avenue, 12th Floor - Suite 1200, Nashville, TN, 37203, USA, - - 2014
The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data were included. Participants were categorized into ...
Salkic Sabina S Emergency medical services, Community Health Centre - - 2014
The objective of this study is to evaluate the incidence and clinical presentation of hypertensive crises in the Emergency medical services of the Community Health Centre "Dr. Mustafa Šehović" Tuzla in relation to age, sex, duration and severity of hypertension, as well as the prevalence of accompanying symptoms and clinical ...
Channanath Arshad Mohamed AM Dasman Diabetes Institute, Dasman, - - 2014
Given that BMI correlates with risk of Type 2 diabetes mellitus (T2DM), and that hypertension is a common comorbid condition, we hypothesize that hypertension augments significantly the impact of obesity on T2DM onset. We obtained data on T2DM in Kuwaiti natives from Kuwait Health Network Registry. We considered 1339 comorbid ...
Pena Geórgia das Graças Gd Maternal-Child Nursing and Public Health Department of the Nursing School, Nursing School, Federal University of Minas Gerais, (UFMG), 30130-100 Belo Horizonte, MG, - - 2014
Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. ...
Fukami Kei K Division of Nephrology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011 Japan ; Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, - - 2014
Advanced glycation end products (AGE)-receptor for AGE (RAGE) axis and renin-angiotensin system (RAS) play a role in diabetic nephropathy (DN). Matrix metalloproteinase-2 (MMP-2) activation also contributes to DN. However, the pathological interaction among AGE-RAGE, RAS and MMP-2 in DN remains unknown. We examined here the involvement of AGE and RAS ...
Distrutti Eleonora E S.C. di Gastroenterologia ed Epatologia, Azienda Ospedaliera di Perugia, Perugia, - - 2014
The intestinal microbiota is increasingly recognized as a complex signaling network that impacts on many systems beyond the enteric system modulating, among others, cognitive functions including learning, memory and decision-making processes. This has led to the concept of a microbiota-driven gut-brain axis, reflecting a bidirectional interaction between the central nervous ...
Cheng Susan S aBrigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA bNational University Health System, Singapore cNovartis, East Hanover, New Jersey dState University of New York at Buffalo, Buffalo, New York eUniversity of Alabama, Birmingham, Alabama fUniversity of Michigan, Ann Arbor, Michigan, - - 2014
Diastolic dysfunction is associated with adverse outcomes and is highly prevalent among older adults with hypertension. Lowering SBP with antihypertensive therapy has been shown to improve diastolic function, but whether or not age influences this effect is unknown. In the Exforge Intensive Control of Hypertension to Evaluate Efficacy in Diastolic ...
Juillière Yves Y Cardiology Department, institut Lorrain du coeur et des vaisseaux, allée du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address: - - 2013
Chronic heart failure (CHF) is a frequent severe disease. Disease-management programmes, which contain a therapeutic patient education component, will play a central role in improving delivery of care and reducing mortality and hospitalizations for CHF. In order to have an up-to-date overview of medical treatment of CHF in France implemented ...
Thawornchaisit Prasutr P School of Medicine, The University of Queensland. - - 2014
Surveys for chronic diseases, and large epidemiological studies of their determinants, often acquire data through self-report since it is feasible and efficient. We examined validity and associations of self-reported hypertension, as verified by physician telephone interview among participants in a large ongoing Thai Cohort Study (TCS). The TCS investigates the ...
Karlsgodt Katherine H - - 2013
Schizophrenia is considered a neurodevelopmental disorder, but whether the adolescent period, proximal to onset, is associated with aberrant development in individuals at clinical high risk (CHR) for psychosis is incompletely understood. While abnormal gray and white matter development has been observed, alterations in functional neuroimaging (fMRI) parameters during adolescence as ...
Entonen Anitta H - - 2013
Migraine has been suggested to be associated with hypertension. The aim of the present 5-year prospective cohort study was to examine whether self-reported migraine in 1998 predicted hypertension in 2003 in a Finnish working-age population. This cohort study consisted of 13 454 randomly selected initially non-hypertensive working-age participants of the ...
Talaei Mohammad - - 2013
The present study aimed to investigate the incidence and predictors of hypertension in an Iranian adult population. Isfahan Cohort Study was a longitudinal population-based study that was conducted on adults aged 35 years or older, living in urban and rural areas of three districts in central Iran. After 7 years ...
Power Melinda C - - 2013
Studies of hypertension and cognition variously report adverse, null, and protective associations. We evaluated evidence supporting three potential explanations for this variation: an effect of hypertension duration, an effect of age at hypertension initiation, and selection bias due to dependent censoring. The Normative Aging Study is a prospective cohort study ...
Ventetuolo Corey E - - 2013
Female sex is a risk factor for pulmonary arterial hypertension (PAH), yet females have better survival than males. We sought to determine if sex was associated with baseline hemodynamics in subjects with PAH, and whether age modified these relationships.We conducted a pooled analysis from 11 randomized trials submitted to the ...
Ho B K - - 2013
The objective of this study was to determine the prevalence and factors associated with the awareness, treatment and control of hypertension among the elderly population in Malaysia. Analysis of secondary data from a cross-sectional national population based survey using stratified multistage sampling conducted from April to August 2006 throughout Malaysia ...
Lapi Francesco - - 2013
BACKGROUND AND AIMS: Poor adherence to medications is a major health concern especially among older subjects. To plan future studies to improve adherence, an epidemiological study, called "Fiesole Misurata", was conducted. The aim of the present paper was to verify the representativeness of the database in evaluating the AntiHyperTensives (AHTs)-taking ...
Wang J - - 2013
This study aims to investigate the trends in prevalence, awareness, treatment and control of hypertension among rural residents aged 35-74 years in northern China during the country's rapid economic development from 1991 to 2011. Two surveys, conducted in 1991and 2011, included 2196 and 1939 participants aged 35-74 years from same ...
Sumner Helen H Respiratory Research Group, Faculty of Medicine and Human Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United - - 2013
Cough is one of the principal symptoms of chronic obstructive pulmonary disease (COPD) but the potential drivers of cough are likely to be multifactorial and poorly understood. To quantify cough frequency in an unselected group of subjects with COPD and investigate the relationships between cough, reported sputum production, smoking, pulmonary ...
Vacek James L - - 2013
Adults with developmental disability (DD) have high prevalence of coronary artery disease risk factors, as well as impediments to optimal diagnosis and management. We analyzed antihypertensive medication (AM) use and adherence patterns in a Kansas Medicaid cohort. We studied adults (18-64 years) with DD and claims for HT from 7/1/05 ...
Wong J S - - 2013
Atrial fibrillation (AF) is usually asymptomatic and often associated with established cardiovascular risk factors such as hypertension. The prevalence atrial fibrillation in patients admitted to Malaysian hospitals has been determined, but asymptomatic atrial fibrillation (AAF) in hypertensive patients in the primary care setting is not established. This study reports the ...
Kuroczycka-Saniutycz Elżbieta - - 2013
BACKGROUND: Experimental and epidemiological studies have demonstrated that urinary angiotensinogen (AGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension (HT). Several large-scale epidemiological studies have shown that an elevated serum uric acid (SUA) level is associated with HT. The aim of our study was ...
Tao Hehua - - 2013
This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Systolic pressure in the ...
Quan Hude - - 2013
BACKGROUND: This population-based study assessed rates of all-cause mortality, myocardial infarction, heart failure, and stroke for up to 12 years of follow-up in 3.5 million Canadian adults newly diagnosed with hypertension. METHODS: Hypertension cohort, outcomes, and covariates were defined using validated case definitions applied to inpatient and outpatient administrative health ...
Stein Gideon Y - - 2013
AIMS: The burden of heart failure (HF)-related hospitalization and mortality of female patients with HF is substantial. Currently, several gender-specific distinctions have been recognized amongst HF patients, but their relationships to outcomes have not been fully elucidated. Accordingly, in the current work, we aimed to explore gender-specific clinical and echocardiographic ...
Asekun-Olarinmoye Eo - - 2013
The purpose of this study was to determine the prevalence of hypertension in two rural communities of Osun State, Nigeria. A consenting adult population of the Alajue and Obokun rural communities in southwestern Nigeria that presented for the screening exercise participated in this community-based cross-sectional descriptive study. Two hundred and ...
Umeh E O - - 2013
Ultrasound measured Carotid Intima-Media Thickness (CIMT) is a simple and inexpensive tool for assessing the cumulative effects of hypertension on the carotid arterial walls. It is also an independent predictor of future myocardial infarctionand stroke risk. This study compared ultrasound measured CIMT in hypertensive adults with non-smoking normotensive controls. It ...
Dunn Jeffrey H - - 2013
The link between psychological stress and aging is intuitive although the underlying mechanisms are not well defined. Evidence suggests that chronic psychological stress stimulates the autonomic nervous system, renin-angiotensin system, and the hypothalamic-pituitary-adrenal axis when the body attempts to resolve perceived threats to homeostasis. Prolonged activation of these pathways can ...
Lau Dennis H - - 2013
Both ageing and hypertension are known risk factors for atrial fibrillation (AF) although the pathophysiological contribution or interaction of the individual factors remains poorly understood. Here we aim to delineate the arrhythmogenic atrial substrate in mature spontaneously hypertensive rats (SHR). SHR were studied at 12 and 15 months of age ...
Yoneyama Kihei K Johns Hopkins University, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, - - 2012
The aim of the present study was to evaluate how torsion is influenced by left ventricular (LV) remodeling associated with age, sex, and hypertension in a large community-based population. Myocardial shortening and torsion were assessed by tagged cardiac magnetic resonance in 1478 participants without clinically apparent cardiovascular disease in the ...
Lopez Oscar L - - 2012
The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011. Two hundred (70%) of the participants progressed ...
Bilotta Claudio - - 2012
PURPOSE: To analyse, in older community-dwelling people living in Italy's Lombardy region, 8-year trends in new users of spironolactone co-prescribed with angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs); blood test monitoring; and independent predictors of appropriate blood test monitoring. METHODS: The region's administrative health database from 2001 to 2008 ...
Baylis Chris C 1600 SW Archer Rd, Room M544, Department of Physiology and Functional Genomics, University of Florida, POB 100274, Gainesville FL 32667, USA. - - 2012
Females develop less age-dependent loss of renal function, which may be in part due to cardiorenal protective effects of estrogens. The impact of androgen level on cardiovascular-renal health is controversial. Estrogen acts through multiple mechanisms, sometimes beneficial, sometimes damaging, which makes it difficult to predict the effect of hormone replacement ...
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