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Sotiropoulos Ioannis I RIKEN Brain Science Institute, Laboratory for Alzheimer's Disease, Wako-shi, Saitama, Japan Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, - - 2014
Tau-mediated neurodegeneration is a central event in Alzheimer's disease (AD) and other tauopathies. Consistent with suggestions that lifetime stress may be a clinically-relevant precipitant of AD pathology, we previously showed that stress triggers tau hyperphosphorylation and accumulation; however, little is known about the etiopathogenic interaction of chronic stress with other ...
Cenini Giovanna G Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging University of Kentucky, Lexington, KY 40506 - - 2014
Down syndrome (DS) is one of the most common causes of intellectual disability, due to trisomy of all or part of chromosome 21. DS is also associated with the development of Alzheimer disease (AD) neuropathology after the age of 40 years. To better clarify the cellular and metabolic pathways that ...
Parikh Vinay V Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA 19122. Electronic address: - - 2014
Substantial evidence suggests that cerebral deposition of the neurotoxic fibrillar form of amyloid precursor protein, β-amyloid (Aβ), plays a critical role in the pathogenesis of Alzheimer's disease (AD). Yet, many aspects of AD pathology including the cognitive symptoms and selective vulnerability of cortically-projecting basal forebrain (BF) cholinergic neurons are not ...
Inoue Yoshimitsu - - 2014
Purpose: The present study examined sex differences in the sweat gland response to acetylcholine (ACh) in physically trained and untrained male and female subjects. Sweating responses were induced on the forearm and thigh in resting subjects by ACh iontophoresis using a 10% solution at 2 mA for 5 min at ...
Eisenach J H JH Departments of Anesthesiology, Physiology and Biomedical Engineering, Mayo Clinic, 200 First St. SW, Rochester, MN - - 2014
A major feature of endothelial dysfunction is reduced endothelium-dependent vasodilation, which in aging may be due to decreased production of endothelial prostacyclin, or nitric oxide (NO), or both. We tested this hypothesis in 12 younger (age 18-38, 6 women) and 12 older healthy adults (age 55-73, 6 postmenopausal women). Endothelium-dependent ...
Evtugyn Gennady A GA Analytical Chemistry Department of Kazan Federal University, 18 Kremlevskaya Street, Kazan 420008, Russian Federation. Electronic address: - - 2014
New acetylcholinesterase (AChE) sensor based on Ag nanoparticles decorated with macrocyclic ligand has been developed and successfully used for highly sensitive detection of organophosphate and carbamate pesticides. AChE was immobilized by carbodiimide binding on carbon black (CB) layer deposited on a glassy carbon electrode. The addition of Ag nanoparticles decreased ...
Lee Jeong Beom JB Department of Physiology, College of Medicine, Soonchunhyang University, Cheonan, Republic of - - 2014
1.The aim of this study was to quantitatively investigate the age and sex-related differences in sudomotor function in healthy humans. 2.Quantitative sudomotor axon reflex test (QSART) with iontophoresis (2 mA for 5 min) and 10% acetylcholine (ACh) were performed to determine axon reflex-mediated (AXR) and directly activated (DIR) sweating. All ...
Al Zadjali Said S Ministry of Environment and Climate Affairs, P.O. Box 32,1, Muscat 100, Oman; Centre for Environmental Strategy, Faculty of Engineering Physical Sciences, University of Surrey, Guildford, Surrey GU2 7JH, - - 2014
In a study of pesticide use on farms in Oman, over 200 respondents were surveyed from amongst owners of and workers on farms that belonged to a Farmers' Association (FA) and those that did not belong to the FA. A questionnaire was used to gauge attitudes to pesticide use whilst ...
Hart Emma C EC University of - - 2014
Inter-individual variability in sympathetic nerve activity (SNA) has provided insight into integrative mechanisms contributing to blood pressure (BP) regulation in humans. In young people, the influence of high SNA on BP is balanced by lower cardiac output and less adrenergic vasoconstrictor responsiveness. Older people have higher SNA and BP. We ...
Yew Ming Kun MK Department of Civil Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, - - 2014
The objective of this study was to investigate the effects of different species of oil palm shell (OPS) coarse aggregates on the properties of high strength lightweight concrete (HSLWC). Original and crushed OPS coarse aggregates of different species and age categories were investigated in this study. The research focused on ...
Pavuk M M Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. Electronic address: - - 2013
Serum concentrations of 35 ortho-substituted polychlorinated biphenyl congeners (PCBs) were measured in 765 adults from Anniston, Alabama, where PCBs were manufactured between 1929 and 1971. As part of the Anniston Community Health Survey (ACHS), demographic data, questionnaire information, and blood samples were collected from participants in 2005-2007. Forty-six percent of ...
Peshin Sharda Shah SS Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: - - 2014
The study was designed to analyze the incidence and pattern of pesticide poisoning calls reported to the National Poisons Information Centre (NPIC), AIIMS, New Delhi and highlight the common classes of pesticides involved in poisoning. The telephone calls received by the Centre during the thirteen year period (1999-2012) were entered ...
Daly Donna M - - 2013
The prevalence of lower urinary tract storage disorders such as overactive bladder syndrome (OAB) and urinary incontinence (UI) significantly increase with age. Previous studies have shown alterations in detrusor function and urothelial transmitter release but there are few studies which have investigated how the urothelium and sensory pathways are affected. ...
Runkle Jennifer D - - 2013
To compare workplace characteristics, workplace behaviors, and the health beliefs of female farmworkers of childbearing age with actual biomarkers of exposure to organophosphate pesticides and to the fungicide mancozeb. Hispanic and Haitian farmworkers between the ages of 18 and 40 years working in nursery or fernery operations were recruited to ...
Svedberg Pia - - 2013
The aims of the present study are to investigate whether there are differences in health-related quality of life (HRQoL) between girls and boys in two different age groups, to study how much of children's variance in HRQoL can be explained by common psychosomatic health symptoms, and to examine whether the ...
Bohnen Nicolaas I NI From the Department of Radiology, Division of Nuclear Medicine (N.I.B., K.A.F., R.A.K., P.J.H.S., M.L.T.M.M.), and Department of Neurology (N.I.B., K.A.F., V.K., R.L.A.), University of Michigan; Neurology Service and GRECC (N.I.B., R.L.A.), VAAAHS, Ann Arbor, MI; and Department of Internal Medicine (S.S.), Division of Geriatrics, University of Pittsburgh, - - 2013
We investigated dopaminergic and cholinergic correlates of gait speed in Parkinson disease (PD) and non-PD control subjects to test the hypothesis that gait dysfunction in PD may result from multisystem degeneration. This was a cross-sectional study. Subjects with PD but without dementia (n = 125, age 65.6 ± 7.3 years) ...
Kemp J - - 2013
With aging, skin is likely to become less hydrated, thereby increasing its resistance to electrical current. This, rather than sensorial/perceptual differences per se, may be the primary cause of differences between younger and older adults in somatosensorial perception in response to electrical stimuli. To assess whether aging alters the perception ...
Topczewski Joseph J - - 2013
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents ...
Libertini G - - 2013
In the late seventies, a small tribal population of Paraguay, the Ache, living under natural conditions, was studied. Data from this population turn out to be useful for considerations about evolutionary hypotheses on the aging phenomenon. 1) Ache show an age-related increasing mortality, which strongly limits the mean duration of ...
Burgerhout Erik - - 2013
European eels (Anguilla anguilla) migrate ~6000km towards their spawning area in the Sargasso Sea. Based on the recent discovery that males swim even more efficiently than females, it was predicted that males also would be able to swim ~6000km within six months. Additionally, eels do not mature naturally in captivity ...
Smith Caroline J - - 2013
Aging is associated with attenuated thermoregulatory function which varies regionally over the body. Decrements in vasodilation and sweating are well documented with age yet limited data are available concerning the regional relation between these responses. We aimed to examine age-related alterations in the relation between regional sweating (RSR) and skin ...
Zilkens Renate R - - 2013
The Australian Pharmaceutical Benefits Scheme (PBS) first subsidized cholinesterase inhibitors (CEIs) for Alzheimer's disease in 2001, introducing a novel therapy for a previously untreatable common condition. This study aims to determine Australian rates of CEI use and to assess equality of access to treatment based on socioeconomic status and geographic ...
Bertrand Marion - - 2013
Dementia is considered as underdiagnosed. We examined whether the proportion of persons aged 65 years and older who had been diagnosed as demented has changed over a 7-year period. The study population was constituted by a cohort of about 70,000 persons who were representative of the French elderly covered by ...
Orhan Ilkay Erdogan - - 2013
Inhibitory effect of the n-hexane, dichloromethane, ethyl acetate, and ethanol extracts from Anethum graveolens L. (dill) cultivated under organic (AG-O) and conventional (AG-C) conditions was tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase at 200 μg mL(-1). Their antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), N,N-dimethyl-p-phenylendiamine (DMPD), and nitric oxide ...
King Kerensa A - - 2013
The listing of several runs of Pacific salmon as threatened or endangered and associated federal, state, and local efforts to restore/enhance salmon habitat in the Pacific Northwest make it imperative that the factors associated with these population declines are understood. Prespawn mortality (PSM) has been documented in coho salmon (Oncorhynchus ...
Chandar Nellore Bhanu - - 2013
We have examined the aging process of soman inhibited AChE using Density functional theory (DFT) calculations. The catalytic serine of AChE can be phosphonylated by the nerve agent soman, and subsequently can undergo an aging process. The consequences of irreversible inhibition of AChE due to the aging process is fatal ...
Dhalla Amar Santosh - - 2013
Serum cholinesterase (SChE) activity is considered as a biomarker and is also taken as an exposure index to assess the low level, chronic residue exposures among sprayers. Thus, cholinesterase activity was studied in the professional rural Punjabi sprayers of Bathinda district in Punjab. This study was made to estimate the ...
Jiang Wei - - 2013
Exposure to nerve agents or organophosphorus pesticides (OP) can have life-threatening effects. Human plasma butyrylcholinesterase (BChE) inactivates these poisons by binding them to serine 198. After hours or days, these OP adducts acquire a negative charge by dealkylation in a process called aging. Our goal was to develop a method ...
Chennupati Ramesh - - 2013
BACKGROUND AND PURPOSE: We investigated the effects of aging on the contributions of nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) to endothelium-dependent relaxation in saphenous arteries of male and female C57BL/6J mice aged 12, 34, and 64 weeks. EXPERIMENTAL APPROACH: Vasomotor responses of saphenous arteries were analyzed by wire-myography in ...
Jiang Wei W Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, - - 2013
The phosphoramidate nerve agent tabun inhibits butyrylcholinesterase (BChE) and acetylcholinesterase by making a covalent bond on the active site serine. The adduct loses an alkyl group in a process called aging. The mechanism of aging of the tabun adduct is controversial. Some studies claim that aging proceeds through deamination, whereas ...
Fujii Naoto N The University of Oregon, Department of Human Physiology, Eugene, OR 97403-1240, - - 2013
Cigarette smoking attenuates acetylcholine (ACh)-induced cutaneous vasodilation in humans, but the underlying mechanisms are unknown. We tested the hypothesis that smokers have impaired nitric oxide (NO)- and cyclooxygenase (COX)-dependent cutaneous vasodilation to ACh infusion. Twelve young smokers, who have smoked more than 5.2 ± 0.7 yr with an average daily ...
Chastanet S - - 2013
To report the patterns of reflux in the great saphenous vein as well as to investigate the correlations between patterns of reflux, the demographics and the clinical findings in the population studied. A total of 1882 limbs were assessed by duplex ultrasound examination in 1449 patients (348 men and 1101 ...
Rehman Rehana - - 2013
The objective of the study was to identify the occurrence and outcome of low back ache amongst computer users and their relation to age, gender, occupation and duration of computer use. A self reported questionnaire tailored from Occupational Health and Safety Act of the Ministry of Labor, Ontario, Canada was ...
Westcott Erika B EB Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, - - 2013
Abstract  Mesenteric arteries (MAs) are studied widely in vitro but little is known of their reactivity in vivo. Transgenic animals have enabled Ca(2+) signalling to be studied in isolated MAs but the reactivity of these vessels in vivo is undefined. We tested the hypothesis that ageing alters MA reactivity to ...
Tahir Seema - - 2012
The exposure assessment study was conducted in the southern Punjab, the cotton growing area of Pakistan among two female groups, one as cotton pickers (occupationally exposed) and the other group as non-pickers. The average blood cholinesterase activity before the spraying in non-pickers were found to be 5.32 ± 0.70 kU/L with the average ...
Sirin Gulseher Sarah - - 2012
Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ACh) and terminates synaptic signals. The catalytic serine of AChE can be phosphonylated by soman, one of the most potent nerve agents, and subsequently undergo an aging reaction. This phosphonylation and aging process leads to ...
Krill Aaron - - 2012
PURPOSE: While compensatory hypertrophy is expected in solitary kidneys, the definition of appropriate hypertrophy remains unclear. The normal renal growth rate in children age 1 to 18 years with 2 kidneys has been defined as 0.28 × age (years) + 6.1. Solitary kidneys appear to grow faster and larger and, ...
Speight K N - - 2012
The wild and captive koala population of the Mt Lofty Ranges in South Australia has a high level of renal dysfunction in which crystals consistent with calcium oxalate have been observed in the kidneys. This study aimed to describe the pathological features of the renal disease in this population, confirm ...
De Nicola Luca - - 2012
To define whether age modifies the prognosis of patients with chronic kidney disease (CKD) on nephrology care, we prospectively followed patients with CKD who have been receiving nephrology care in a clinic for 1 year or more. The incidence of end-stage renal disease (ESRD), defined by the occurrence of dialysis ...
Lora Claudia M - - 2012
Despite the large burden of chronic kidney disease (CKD) in Hispanics, this population has been underrepresented in research studies. We describe the recruitment strategies employed by the Hispanic Chronic Renal Insufficiency Cohort Study, which led to the successful enrollment of a large population of Hispanic adults with CKD into a ...
Sasser Jennifer M - - 2012
Aging kidneys exhibit slowly developing injury and women are usually protected compared with men, in association with maintained renal nitric oxide. Our purpose was to test 2 hypotheses: (1) that aging intact Fischer-344 (F344) female rats exhibit less glomerular damage than similarly aged males, and (2) that loss of female ...
Anne McRobert E - - 2012
Advanced glycation endproducts (AGEs) are important mediators of diabetic complications via incompletely understood pathways. We previously showed that AGEs bind to intracellular ERM proteins (ezrin, radixin and moesin), which modulate cell shape, motility, adhesion and signal transduction. AGEs bind to the N-terminal domain but not full-length ezrin. The AGE binding ...
Li Yonghua - - 2012
This cross-sectional study aimed to investigate blood mercury (B-Hg) concentration of residents living in the vicinity of Chatian mercury mine (CMM) in southwestern China and to assess the possible effects on renal function. It evaluates the effects of gender and age (children, <18 years; adults, 18-60 years; elderly, >60 years) on the B-Hg ...
Raghul Manian - - 2012
Prediction equations of glomerular filtration rate (GFR) may facilitate early detec-tion, evaluation and management of chronic kidney disease (CKD). However, the reliability of these equations was not extensively studied in our CKD population. Hence, the present study was aimed to determine the performance of modification of diet in renal disease ...
Ibrahim Salwa - - 2012
Our study aimed to obtain a comprehensive review of the incidence of biopsy-proven glomerulonephritis (GN) at the Cairo University Hospitals, Egypt, over the last five years. We analyzed the clinical and pathological data of all renal biopsy samples that were performed during the period from July 2003 to July 2008. ...
Hemmelgarn Brenda R - - 2012
CONTEXT Studies of kidney failure in older adults have focused on receipt of dialysis, which may underestimate the burden of disease if older people are less likely to receive treatment. OBJECTIVE To determine the extent to which age is associated with the likelihood of treatment of kidney failure. DESIGN, SETTING, ...
O'Brien Benjamin - - 2012
Increasing demand for donor kidneys, in parallel with trends toward more elderly and obese populations, make it important to continuously review donor pool inclusion criteria. Acceptance of elderly and obese living donors remains controversial, with a higher incidence of comorbidity and the greater risk of postoperative complications sighted as reasons ...
Pinto Vanda - - 2012
In the present study we hypothesised that age-associated changes in the renal aldosterone/mineralocorticoid receptor (MR) system may differ between normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). In WKY, body mass index significantly increased with age. Fat mass may operate as a confounding factor; therefore, WKY (WKY-FR) were pair-fed with ...
N Hew Miki - - 2012
PURPOSE: We evaluated the influence of age on gender related differences in the renal cell carcinoma presentation of patients operated on between 1995 and 2005 in a European country. We also assessed the trend of missing pathological data. MATERIALS AND METHODS: Data on all patients who underwent radical or partial ...
Lins Fernanda Luiza de Miranda Lins E - - 2012
This study aimed to characterize anatomical and biochemical properties of owl monkey kidneys in order to provide normal reference values. Sixty-nine Aotus azarai infulatus (45 males and 24 females) were divided into four different age groups (AG1: 3 months-1 year; AG2: 2-3 years; AG3: 4-6 years; and AG4: over 7 ...
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