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Fortress Ashley M AM Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, - - 2014
Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone acetylation has been associated with age-related memory decline in male rodents, little is known about whether histone acetylation is altered by aging in female rodents. In young female mice, the ability of 17β-estradiol (E2) to ...
Daryabari H H Department of Animal Science, College of Agriculture, Shiraz University, Shiraz 71441-65186, - - 2014
Published data on the probable involvement of avidin and avidin-related protein-2 (AVR2) in sustaining sperm viability in sperm storage tubules in 38-wk-old turkeys, and the high affinity of avidin or its analogs to biotin suggest that supplementary biotin may increase oviductal avidin and AVR2 expression, thereby attenuating the adverse effect ...
Kirejczyk Jan K JK Department of Pediatric Surgery, Medical University of Bialystok, Bialystok, - - 2014
Hypocitraturia is considered a major risk factor for calcium stone formation. However, there is no widely accepted reference database of urinary citrate excretion in children. The aim of our study was to determine the amount of citrate eliminated in the urine over a 24-h period in a pediatric cohort and ...
Eisenberg Tobias T Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, - - 2014
Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast. Blocking the ...
Keller Guillermo Alberto - - 2014
Introduction: Metabolic clearance of isoniazid (INH) may be up to 10 times faster in individuals who are rapid acetylators compared with slow acetylators. In addition, the acetylation phenotype has been suggested to change with age. A better knowledge of the age distribution of the acetylation genotype and phenotype in children ...
Nagasawa Miho M Department of Animal Science and Biotechnology, Azabu - - 2014
This study aimed to investigate the therapeutic effects of N-acetyl-d-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error ...
Zhang Hualin H Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan, 430070, P.R. China - - 2014
Abstract Histone acetylation is one of the most important posttranslational modifications that contribute to transcriptional initiation and chromatin remodeling. In our previous study, we enhanced sperm chromatin remodeling within the bovine sperm injection-derived androgenentic (SpI-AG) embryos by sperm pretreatment, and thereby improved their early developmental competence. In this study, we ...
Coplan Jeremy D JD Department of Psychiatry, Division of Neuropsychopharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, - - 2014
We previously demonstrated an inverse relationship between both dentate gyrus neurogenesis - a form of neuroplasticity - and expression of the antiapoptotic gene marker, BCL-2 and adult macaque body weight. We therefore explored whether a similar inverse correlation existed in humans between body mass index (BMI) and hippocampal N-acetyl-aspartate (NAA), ...
Eckoldt-Wolke Felicitas F Clinic for Pediatric Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, - - 2014
This chapter refers only to female patients with congenital adrenal hyperplasia (CAH). CAH represents the largest subgroup of individuals with 46,XX disorders of sex development. The stimulation of the androgen production leads to a prenatal virilization among these girls. The phenotype is influenced by the severity of the enzyme defect, ...
Tomaiuolo Francesco F Auxilium Vitae Volterra, Volterra, - - 2014
We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect ...
Montalvo-Ortiz Janitza L JL Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL, - - 2013
Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psychopathological conditions, including psychosis and the behavioral disturbances associated with dementia. However, clinical experience suggests these drugs may be less efficacious in the elderly individuals than in the young. Recent studies suggest that aging may ...
Suri Deepika - - 2013
The early stress of maternal separation (ES) exerts long-lasting effects on cognition and anxiety. Recent evidence indicates enhanced hippocampus-dependent spatial learning in young adult ES animals, which shifts towards a decline in long-term memory in middle-aged life. Further, we find that ES animals exhibit enhanced anxiety in young adulthood that ...
Pavlopoulos Elias - - 2013
To distinguish age-related memory loss more explicitly from Alzheimer's disease (AD), we have explored its molecular underpinning in the dentate gyrus (DG), a subregion of the hippocampal formation thought to be targeted by aging. We carried out a gene expression study in human postmortem tissue harvested from both DG and ...
Lin Chien-Yu - - 2013
Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based ...
Jennings Benjamin C BC Life Sciences Institute, 210 Washtenaw Avenue, University of Michigan, Ann Arbor, Michigan 48109-2216, United - - 2013
The upsurge in drug-resistant tuberculosis (TB) is an emerging global problem. The increased expression of the enhanced intracellular survival (Eis) protein is responsible for the clinical resistance to aminoglycoside (AG) antibiotics of Mycobacterium tuberculosis . Eis from M. tuberculosis (Eis_Mtb) and M. smegmatis (Eis_Msm) function as acetyltransferases capable of acetylating ...
Chiu Pui-Wai - - 2013
Magnetic resonance spectroscopy (MRS) can explore aging at a molecular level. In this study, we investigated the relationships between regional concentrations of metabolites (such as choline, creatine, myo-inositol, and N-acetyl-aspartate) and normal aging in 30 cognitively normal subjects (15 women and 15 men, age range 22-82, mean = 49.9 ± 18.3 years) using quantitative proton ...
Matozzo Valerio - - 2013
In this study, the seasonal variations in the morphometric features and in the cellular and biochemical parameters of the haemolymph were investigated in both male and female crabs (Carcinus aestuarii). Crabs were seasonally (November 2010-August 2011) collected from the Lagoon of Venice, and the moult stage, weight, width and length ...
Xu Cheng - - 2013
SIRT1, a longevity regulator and NAD(+)-dependent deacetylase, plays a critical role in promoting metabolic fitness associated with calorie restriction and healthy ageing. Using a tissue-specific transgenic approach, the present study demonstrates that over-expression of human SIRT1 selectively in adipose tissue of mice prevents ageing-induced deterioration of insulin sensitivity and ectopic ...
Mondino Marine M EA4615, CH le Vinatier, Université Claude Bernard Lyon 1 , Lyon , - - 2013
Reduced N-acetyl-aspartate (NAA) levels have been reported in the prefrontal cortex (PFC) in patients with schizophrenia using proton magnetic resonance spectroscopy. However, it is unclear whether this NAA reduction predates the illness onset and is reported in subjects at-risk for developing schizophrenia (HRS). The aim of this study was to ...
Lee Ah Reum AR Division of Biological Science, Graduate School of Biology-Oriented Science and Technology, Kinki University, Wakayama 649-6493, - - 2013
Postovulatory mammalian oocyte developmental potential decreases with aging in vivo and in vitro. Aging oocytes typically show cellular fragmentation and chromosome scattering with an abnormally shaped spindle over time. Previously, it was shown that histone acetylation in the mouse oocyte increased during aging and that treatment with trichostatin A (TSA), ...
Zhang Wuxia - - 2012
The linear non-sulfated glycosaminoglycan, hyaluronic acid (HA), is widely distributed throughout connective, epithelial and neural tissues etc., and is of great importance in tissue hydration, lubrication and cellular function. Along with the age growth, HA will lose its acetyl groups under action of HA N-deacetylase in vivo. However, the biological ...
Baltan Selva S Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. - - 2012
Aging increases the vulnerability of aging white matter to ischemic injury. Histone deacetylase (HDAC) inhibitors preserve young adult white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. In isolated optic nerve from 12-month-old mice, deprived of oxygen and glucose, we show that pan- and Class I-specific ...
Pricer Rachel E - - 2012
The Mycobacterium tuberculosis enhanced intracellular survival (Eis_Mtb) protein is a clinically important aminoglycoside (AG) multi-acetylating enzyme. Eis homologues are found in a variety of mycobacterial and non-mycobacterial species. Variation of the residues lining the AG-binding pocket and positions of the loops bearing these residues in the Eis homologues dictates the ...
Watanabe Ken-Ichi - - 2012
It is currently accepted that epigenetics plays an important role in normal genetics and differentiation, and its failure triggers various diseases such as cancer, aging, metabolic diseases, and abnormal differentiations. The typical mechanism involves the modification of histones and the methylation of DNA. In this study, we investigated the modification ...
Chervona Yana Y Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, - - 2012
Exposure to arsenic (As) is associated with an increased risk of several cancers as well as cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro. Water and urinary As concentrations as well as global levels of histone 3 ...
Piesiewicz A - - 2012
Previously, we have demonstrated that the timing of the nocturnal peak of activity of the pineal arylalkylamine-N-acetyltransferase - a key enzyme in the melatonin biosynthesis pathway - in 3-wk-old chickens kept from the day of hatch under controlled laboratory conditions (L:D 12:12) varies depending on the season of hatch (summer ...
Nahomi Rooban B RB Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, - - 2013
N(ε)-acetylation occurs on select lysine residues in α-crystallin of the human lens and alters its chaperone function. In this study, we investigated the effect of N(ε)-acetylation on advanced glycation end product (AGE) formation and consequences of the combined N(ε)-acetylation and AGE formation on the function of α-crystallin. Immunoprecipitation experiments revealed ...
Chen Wenjing - - 2012
We previously demonstrated that aminoglycoside acetyltransferases (AACs) display expanded cosubstrate promiscuity. The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis is responsible for the resistance of this pathogen to kanamycin A in a large fraction of clinical isolates. Recently, we discovered that Eis is a unique AAC capable of acetylating ...
Picone Simonetta - - 2012
OBJECTIVE: Lutein is an antioxidant carotenoid exerting a key role in eye health, but no reference curve in the perinatal period is available. DESIGN AND METHODS: We conducted a prospective study on the distribution of lutein and its metabolite 3'-oxolutein in arterial cord blood of preterm (n=40) and term (n=76) ...
Liang Xingwei - - 2012
It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age. Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process. Here, we review the epigenetic alterations, mainly focused on DNA methylation, ...
Hirano Kenichi - - 2012
BACKGROUND: The Japanese Orthopaedic Association has proposed the term locomotive syndrome ("locomo") to designate a condition of individuals in high-risk groups with musculoskeletal disease who are highly likely to require nursing care. The specific characteristics of "locomo" must still be determined. The spinal column is a major and important component ...
Eslami V - - 2012
Study design:Cross-sectional observational study.Objectives:To examine variables associated with the development of pressure ulcers (PU) in subjects with spinal cord injury (SCI).Setting:SCI patients under coverage of the State Welfare Organization of Iran.Methods:Mobile rehabilitation teams gathered data from 20 of the 30 provinces in Iran. There were 8104 SCI patients registered in ...
Alshahri S S - - 2012
Study design:Retrospective study.Objectives:To review traumatic spinal cord injury (TSCI) rates and epidemiology at the Riyadh Military Hospital (RMH) in Saudi Arabia and to hypothesise strategies for a more integrated approach to injury prevention in Saudi Arabia.Setting:RMH, Rehabilitation Division.Methods:A review was conducted of all patients with TSCI aged 14 years admitted ...
Oh Moo-Kyung - - 2012
The objective of this study was to identify the differences in obesity rates among people with and without disabilities, and evaluate the relationship between obesity rates and the existence of disabilities or characteristics of disabilities. Mass screening data from 2008 from the National Disability Registry and National Health Insurance (NHI) ...
Celigoj F Andrew - - 2012
PURPOSE: There are limited reports regarding the semen quality of men who sustained a spinal cord injury during the prepubertal period. We performed a retrospective chart review of 533 subjects with spinal cord injury to identify those injured during the prepubertal period and to characterize the semen quality of this ...
New P W - - 2012
Study design:Forecasting using population modelling.Objectives:To determine the prevalence of non-traumatic spinal cord injury (NTSCI) on 30 June 2010.Setting:Victoria, Australia.Methods:Modelling used the following data: incidence of NTSCI based on state-wide, population-based, health-administration database of hospital admissions; state and national population profiles and life tables; levels of NTSCI based on national rehabilitation ...
Middleton J W JW Rehabilitation Studies Unit, The University of Sydney, NSW State Spinal Cord Injury Service, Agency for Clinical Innovation, Sydney, Australia. - - 2012
Cohort of incident cases from 1955 to 2006. To analyse acute and long-term mortality, estimate life expectancy and identify survival patterns of individuals experiencing traumatic spinal cord injury (SCI). Specialised SCI unit in Australia. Data for patients with traumatic SCI admitted to a spinal unit in Sydney, Australia between January ...
Anderson Heather A - - 2012
Higher prevalence of strabismus in individuals with spina bifida myelomeningocele (SBM) has previously been attributed to hydrocephalus; however, SBM is associated with many other complications. This study investigates the relation between strabismus and other factors in SBM. Children aged 3 to 18 years with SBM (n = 112) received an ...
Pérez Katherine - - 2012
AIMS: The aim of the present study was to estimate the incidence of hospital discharges for traumatic spinal cord injury (TSCI) and traumatic brain injury (TBI) in Spain by injury circumstances (traffic crashes and others), injury severity, gender and age group and to describe its trends over the period 2000-2009. ...
Wu Q Q Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, People's Republic of - - 2012
A retrospective epidemiological study. To describe the recent epidemiological characteristics of traumatic cervical spinal cord injury (TCSCI) in adults in Tianjin. Tianjin Medical University General Hospital. This study included all TCSCI patients aged ≥ 15 years who were admitted to a general hospital from December 2008 to November 2011. Epidemiological ...
Chazono Masaaki - - 2012
The aims of this study were to review published data on pedicle dimensions and bony spinal canal diameters calculated from CT examinations of the cervical spine through the English-language literature and analyze these data for ethnic disparities and similarities. The authors reviewed the literature on "pedicle" and "spinal canal" by ...
Bach John R - - 2012
OBJECTIVE: This work describes and correlates plateau/maximum observed vital capacity (VC) with spinal muscular atrophy (SMA) severity and prognosis for autonomous breathing. DESIGN: SMA severity was correlated with VC, onset, paradoxical breathing, age at definitive dependence on continuous mechanical ventilation (DDCV), and age at first respiratory hospitalization and gastrostomy. RESULTS: ...
Sakakibara B M - - 2012
Systematic review. To identify changes in subjective quality of life (QoL) as one ages with a spinal cord injury (SCI). Vancouver, Canada. Electronic databases were searched for studies reporting on age-related QoL changes over time. Data from relevant studies were transcribed into data extraction forms and analyzed by years post ...
Sweet Shane N - - 2012
Objective: It is crucial to understand long-term leisure time physical activity (LTPA) patterns of persons with spinal cord injury (SCI) as the challenges of living with this disability heavily influence LTPA levels. The purpose of this study was to explore emerging LTPA patterns in a sample of persons with SCI ...
Olgun Zeynep Deniz - - 2012
Study Design. Longitudinal case study.Objective. To determine if pedicle screws placed in an immature spine exert effect on the continued growth of the vertebral body.Summary of Background Data. Pedicle screws have revolutionized surgical treatment of spinal deformities by allowing a mode of secure fixation that provides consistently better correction rates ...
Phillips V L - - 2012
Study design:We analyzed longitudinal data on secondary outcomes from participants in a telerehabilitation study.Objectives:To examine the factors affecting return to productive activities and employment and the time to these events following a spinal cord injury (SCI).Setting:A large southeastern rehabilitation hospital in the United States.Methods:We used hazard regression models to analyze ...
Hwang M - - 2012
Study design:Cross-sectional surveyObjectives:To assess the prevalence of substance use in young adults with pediatric-onset spinal cord injury (SCI) and its relationship with demographic factors, and medical and psychosocial outcomes.Setting:Young adults living in the United States who received pediatric SCI care at one of three SCI programs at the Shriners Hospitals ...
Metring N L - - 2012
Study design:Cross-sectional study.Objectives:To evaluate the efficacy of the Postural Assessment Software PAS/SAPO in the posture analysis of individuals with spinal cord injury (SCI) during sitting position and to analyze if the use of different types of seat cushions-gel and foam, with no cushion-can interfere in the individual's posture during sitting ...
Krause James S - - 2012
Krause JS, Ricks JM. Stability of vocational interests after recent spinal cord injury: comparisons related to sex and race. OBJECTIVE: To identify the stability of vocational interests first assessed during inpatient rehabilitation for spinal cord injury and again an average of 834.9 days postinjury to determine the extent to which ...
van den Berg Maayken E L - - 2012
To assess the incidence of nontraumatic spinal cord injury (SCI) in a determined catchment area in Spain, and to evaluate clinical presentations and trends over time. Population-based case series study between January 1972 and December 2008 [corrected]. A hospital with a specialized SCI unit in a delimited health area in ...
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