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Wang Xiang-Qing - - 2014
To examine the association between headaches and epilepsy. Consecutive adult epileptic patients who went to the outpatient clinic of the Epilepsy Center of PLA General Hospital between February 01, 2012, and May 10, 2013, were recruited into this study. A total of 1109 patients with epilepsy completed a questionnaire regarding ...
May T W TW Epilepsy Center Bethel, Society for Epilepsy Research, Bielefeld, - - 2014
Due to demographic change and high incidence of epilepsy in elderly, the number of elderly with epilepsies is increasing. However, only few studies investigated the impact of epilepsy on quality of life (QoL). We investigated how epilepsy affects different aspects of QoL dependent on the age of the patients and ...
Carlson Chad C Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: - - 2014
Despite the increasing interest in sex differences in disease manifestations and responses to treatment, very few data are available on sex differences in seizure types and semiology. The Epilepsy Phenome/Genome Project (EPGP) is a large-scale, multi-institutional, collaborative study that aims to create a comprehensive repository of detailed clinical information and ...
Keezer Mark R MR Neuroepidemiology Research Unit, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, - - 2014
Accurate estimates of the incidence and prevalence of epilepsy allow us to better assess its societal impact. Prevalence and incidence studies often use unvalidated screening tools resulting in estimates of uncertain accuracy. We present the Canadian Longitudinal Study on Aging-Epilepsy Algorithm (CLSA-EA) as well as the results of our validation ...
Stephens Michelle L ML Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, - - 2014
Characterize glutamate neurotransmission in the hippocampus of awake-behaving rodents during focal seizures in a model of aging. We used enzyme-based ceramic microelectrode array technology to measure in vivo extracellular tonic glutamate levels and real-time phasic glutamate release and clearance events in the hippocampus of awake Fischer 344 rats. Local application ...
Verma Archana A Japan Epilepsy Research Foundation, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Urushiyama 886, Aoi-Ku, Shizuoka, 420-8688, Japan, - - 2014
Worldwide, mortality associated with epilepsy is a matter of grave concern. The mortality rate in epileptic population is two to three times more than that of the general population. Sudden unexplained death in epilepsy, better known as sudden unexpected death in epilepsy (SUDEP), is a mysterious and rare condition, in ...
Kendirli Mustafa Tansel MT Neurology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey - - 2014
Arrhythmia is not uncommon in the etiology of syncope which mimics epilepsy. Data about the epilepsy induced vagal tonus abnormalities have being increasingly reported. So we aimed to evaluate what a neurologist may gain by a simultaneous electrocardiogram (ECG) and electroencephalogram (EEG) recording in the patients who underwent EEG testing ...
Obiako O R OR Neurology Unit, Department of Medicine, Ahmadu Bello University Teaching Hospital (ABUTH)/Ahmadu Bello University Zaria, Zaria, - - 2014
Epilepsy is a complex chronic illness with variable treatment outcomes determined by factors specific to each affected person. We investigated prognostic factors for epileptic seizure outcome after 2 years of anti-epileptic drug (AED) monotherapy. Two hundred and thirty-four AED naïve epilepsy patients were started on AED monotherapy and monitored for 2 years ...
Soroko S I SI I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences (IEPhB RAS), Saint-Petersburg, - - 2014
The aim of the study was to reveal longitudinal changes in electroencephalogram spectral power and frequency (percentage frequency composition of EEG and alpha peak frequency) patterns in normal children from northern Russia. Fifteen children (9 girls and 6 boys) participated in the study. The resting state (eyes closed) EEGs were ...
Coulehan K - - 2014
Electrical status epilepticus of sleep (ESES) is a rare childhood epilepsy associated with global neuropsychological regression. Typically, ESES consists of bi-hemispheric epileptiform activity, however we present two patients (P1, age 8 & P2, age 11) with focal right hemisphere ESES. Similarities and differences between their neuropsychological profiles are highlighted. Language ...
Geffrey A - - 2014
To test an a priori hypothesis that surgical intervention for intractable epilepsy (IE) will improve quality of life (QOL) in an underserved, primarily immigrant, Hispanic population. Pre- and post-surgical Quality of Life in Epilepsy-31 (QOLIE-31; Spanish Version) results were compared for 22 adult Hispanics (males = 68.2 %; females = ...
Hamed Sherifa A SA Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt. Electronic address: - - 2014
Evidence from epidemiological, longitudinal, prospective, double-blinded clinical trials as well as case reports documents age-accelerated atherosclerosis with increased carotid artery intima media thickness (CA-IMT) in patients with epilepsy. These findings raise concern regarding their implications for age-accelerated cognitive and behavioral changes in midlife and risk of later age-related cognitive disorders ...
Suda Hitoshi H Life Sciences, Course of Biosciences, Tokai University, 3-20-1 Orido, Shimizu-ku, Shizuoka, 424-8610, Japan; School of Marine Science and Technology, Tokai University, 3-20-1 Orido, Shimizu-ku, Shizuoka, 424-8610, Japan. Electronic address: - - 2014
Lifespan among individuals ranges widely in organisms from yeast to mammals, even in an isogenic cohort born in a nearly uniform environment. Needless to say, genetic and environmental factors are essential for aging and lifespan, but in addition, a third factor or the existence of a stochastic element must be ...
Kumar Mritunjay M Assistant Professor, Department of Paediatrics, SGRR Institute of Medical and Health Sciences , Dehradun, Uttarakhand, India - - 2014
Status epilepticus (SE) is a common, life threatening neurologic disorder that is essentially an acute, prolonged epileptic crisis. SE can represent an exacerbation of a pre-existing seizure disorder, the initial manifestation of a seizure disorder, or an insult other than a seizure disorder. To study the aetiology, clinical profile, and ...
Tsao Chang-Yong CY Department of Pediatrics, Nationwide Children׳s Hospital, College of Medicine, The Ohio State University, Columbus, OH; Department of Neurology, Nationwide Children׳s Hospital, College of Medicine, The Ohio State University, Columbus, OH. Electronic address: - - 2014
We encountered an adolescent male with cerebellar ataxia since age 11, difficulty in vertical gaze from age 2, leg weakness since age 10, and partial epilepsy since age 8. At age 14, he developed visual and auditory hallucinations, as well as mild sensorineural deafness. He was evaluated as having a ...
Hobbs William R WR Division of Social Sciences, University of California San Diego, La Jolla, California, United States of - - 2014
We validate an online, personalized mortality risk measure called "RealAge" assigned to 30 million individuals over the past 10 years. 188,698 RealAge survey respondents were linked to California Department of Public Health death records using a one-way cryptographic hash of first name, last name, and date of birth. 1,046 were ...
Esterhammer Regina R Department of Radiology, Medical University Innsbruck, Innsbruck, - - 2014
Recently published studies have elucidated alterations of mitochondrial oxidative metabolism during ageing. The intention of the present study was to evaluate the impact of ageing on cardiac high-energy phosphate metabolism and cardiac function in healthy humans. 31-phosphorus 2-dimensional chemical shift imaging (31P 2D CSI) and echocardiography were performed in 196 ...
Kutsuma Ayano A Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, - - 2014
Skipping breakfast is considered to be an unhealthy eating habit linked to predispositions to obesity and type 2 diabetes. Because eating dinner late at night can elicit subsequent breakfast skipping, we investigated if skipping breakfast concomitant with late-night-dinner eating (LNDE) was associated with metabolic syndrome (MetS) and proteinuria in the ...
White Carl W - - 2013
An age-related increase in prostatic smooth muscle tone is partly responsible for the lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). Changes in the effectors of prostatic smooth muscle contraction with age may play a role in the development of these symptoms. Using a mouse model of prostate ...
Liao Yu-Ju - - 2013
We have developed a simple and selective nanosensor for the optical detection of adenosine triphosphate (ATP) using globular actin-conjugated gold/silver nanorods (G-actin-Au/Ag NRs). By simply mixing G-actin and Au/Ag NRs (length ∼56 nm and diameter ∼12 nm), G-actin-Au/Ag NRs were prepared which were stable in physiological solutions (25 mM Tris-HCl, 150 mM NaCl, 5.0 mM ...
Bozdogan Omer - - 2013
The number of ATP-dependent potassium channels in myocardial cells has been previously shown to change depending on gender and age. Different effects of the ATP-dependent potassium channel blocker, glybenclamide and ATP-dependent potassium channel opener, pinacidil on ischemia or reperfusion-induced arrhythmia observed in various research might depend on different ages and ...
Choi Joon-Seok - - 2013
The free radical theory of aging emphasizes cumulative oxidative damage in the genome and intracellular proteins due to reactive oxygen species (ROS), which is a major cause for aging. Caloric restriction (CR) has been known as a representative treatment that prevents aging; however, its mechanism of action remains elusive. Here, ...
Yaniv Yael Y Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, - - 2013
In advanced age, the resting myocardial oxygen consumption rate (MVO2) and cardiac work (CW) in the rat remain intact. However, MVO2, CW and cardiac efficiency achieved at high demand are decreased with age, compared to maximal values in the young. Whether this deterioration is due to decrease in myocardial ATP ...
Sewaybricker Leticia Esposito - - 2013
To study the agreement among three distinct criteria for metabolic syndrome (MS) adapted to adolescents, and to identify associated factors for MS. Cross-sectional study with 65 obese subjects aged 10 to 18 years, attended to at the Outpatient Clinic for Obese Children and Adolescents at the Clinical Hospital of the ...
Chackrewarthy S - - 2013
Background. The prevalence of metabolic syndrome (MetS) within individual cohorts varies with the definition used. The aim of this study was to compare the prevalence of MetS between IDF and revised NCEP ATP III criteria in an urban Sri Lankan population and to investigate the characteristics of discrepant cases. Methods. ...
Ramli Anis Safura - - 2013
Metabolic syndrome (MetS) is a steering force for the cardiovascular diseases epidemic in Asia. This study aimed to compare the prevalence of MetS in Malaysian adults using NCEP-ATP III, IDF, and JIS definitions, identify the demographic factors associated with MetS, and determine the level of agreement between these definitions. The ...
Topè Avinash M AM Division of Food and Animal Science, College of Agriculture, Food Science and Sustainable Systems, Kentucky State University, Frankfort, KY, 40601, USA. - - 2013
There are limited data on the prevalence rate of Metabolic Syndrome (MetS) among college students attending any Historically Black College and University (HBCU), which are mostly attended by young African Americans (AA). We report the prevalence and gender differences in the components of MetS in a sample population from ...
Cohen Eytan - - 2012
There is a striking increase in the number of people with metabolic syndrome (MetS) as a result of the global epidemic of obesity and diabetes. Increasing evidence suggests that uric acid may play a role in MetS. To assess the prevalence of MetS in a large cohort from Israel and ...
Coen Paul M PM Department of Health and Physical Activity, University of Pittsburgh, Trees Hall Rm 134D, Allequippa St. and Darragh St., Pittsburgh, PA 15260, USA. - - 2013
Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults. Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed ...
Macintyre Jessica N - - 2012
Endothelin-1 (ET-1) is a vasoconstrictor implicated in age-related retinal pathologies. This study determined whether responses to ET-1 differed in retinal arterioles isolated from adult (2-3 months) and aged (>20 months) Fischer 344 rats of both sexes. Risk factors for retinal disease (retinal perfusion pressure, intraocular pressure, blood glucose) were not ...
Browning David J - - 2012
To describe the pharmacokinetics, preclinical studies, and clinical trials of the newly approved anti-vascular endothelial growth factor (VEGF) drug aflibercept (Eylea (VEGF Trap-Eye); Regeneron; and Bayer). Review with editorial commentary. A review of the medical literature and pertinent Internet postings combined with analysis of key studies with expert opinion regarding ...
Coscas Gabriel - - 2012
Purpose. To evaluate choroid thickness (CT) with RTVue spectral domain optical coherence tomography (SD-OCT) and the effect of age and myopia in eyes without posterior complications. Methods. In this multicenter cross-sectional study, all enrolled patients were over age 18 and divided them in 3 groups based on refraction: emmetropia (+1 ...
Tariq Yasser M - - 2012
PURPOSE: To investigate the association of premature birth with macular parameters measured by spectral domain coherence tomography (SD-OCT). METHODS: The Sydney Adolescent Vascular and Eye Study performed eye examinations in school students across Sydney between 2009 and 2011. Visual acuity, cycloplegic autorefraction, and optical biometry measurements were recorded. Macular parameters ...
Ma Wenxin W Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, - - 2013
Age-related macular degeneration is an outer retinal disease that involves aging and immune dysfunction. In the aging retina, microglia aggregate in the outer retina and acquire intracellular autofluorescent lipofuscin deposits. In this study, we investigated whether accumulation of A2E, a key bisretinoid constituent of ocular lipofuscin, alters the physiology of ...
Geirsdottir Asbjorg - - 2012
Purpose: To measure oxygen saturation in retinal vessels of healthy eyes to determine the effects of age, gender, and cardiovascular parameters as well as the reliability of the measurements and topographical differences.Methods: The Oxymap T1 retinal oximeter is based on a fundus camera. It simultaneously captures retinal images at two ...
Steinmetz Andrea - - 2012
The case of a 31-year-old captive female Western lowland gorilla (Gorilla gorilla gorilla) with decreased near vision but good distance vision is presented. Examination of the fundus revealed drusen-like bodies in the macula presumably because of an age-related macular degeneration (AMD).
Erke Maja G - - 2012
PURPOSE: To describe the sex- and age-specific prevalence of drusen, geographic atrophy, and neovascular age-related macular degeneration (AMD). DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Caucasian adults aged 65 to 87 years from the 6th Tromsø Study, a population-based study conducted in 2007-2008 in the municipality of Tromsø, Norway. METHODS: Digital color ...
Lindekleiv Haakon - - 2012
Purpose:  To project the number of persons with late age-related macular degeneration (AMD) in Scandinavia through 2040. Methods:  Age- and sex-specific prevalence rates of late AMD (choroidal neovascularization and geographic atrophy) from the European Eye Study and the Eye Diseases Prevalence Research Group were applied to the projected Danish, Norwegian ...
Goldenberg Dafna - - 2012
BACKGROUND AND OBJECTIVE:To evaluate choroidal thickness at five macular locations and assess the correlations between choroidal thickness at these locations with age, refractive error, and axial length. PATIENTS AND METHODS:Eighty-four eyes from 42 healthy adult volunteers were included. Enhanced depth imaging by spectral-domain optical coherence tomography was performed, and choroidal ...
OʼHara Ruth R Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA 94305, USA. - - 2012
Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults. In a cross-sectional study ...
Jonas Jost B - - 2012
Purpose:  To measure the concentration of cytokines in the aqueous humour of eyes with exudative age-related macular degeneration (AMD). Methods:  The clinical interventional study included a study group of 18 patients with exudative AMD and a control group of 20 patients undergoing routine cataract surgery. Age did not vary significantly ...
Hogg Ruth E - - 2012
PURPOSE: To examine associations between recognized genetic susceptibility loci and angiographic subphenotypes of the neovascular variant of age-related macular degeneration (nvAMD). METHODS: Participants (247 nvAMD, 52 early age-related macular degeneration [AMD], and 103 controls) were genotyped (complement factor H and ARMS2/HTRA1). nvAMD participants were assigned to one of two subcategories: ...
Fujiwara Atsushi - - 2012
PURPOSE: To investigate the subfoveal choroidal thickness of healthy Japanese subjects using enhanced depth imaging optical coherence tomography and to evaluate the association between subfoveal choroidal thickness and age in a group of subjects with a wide age range. SUBJECTS AND METHODS: A total of 145 eyes of 145 healthy ...
Sheffler Lindsey C - - 2012
Elbow flexion contracture is a well-known complication of brachial plexus birth palsy that adversely affects upper-extremity function. The prevalence, risk factors, and rate of progression of elbow flexion contracture associated with brachial plexus birth palsy have not been established, and the effectiveness of nonoperative treatment involving nighttime splinting or serial ...
Chen Yuh-Fang - - 2012
PURPOSE.: This study was designed to analyze macular tomography in patients of different ages with retinitis pigmentosa (RP) and correlate their visual function with macular thickness, which was measured by optical coherence tomography. METHODS.: In all, 75 RP patients and 75 controls were stratified into three age groups and macular ...
Al-Serafi Murad - - 2012
To clarify the efficacy of the macular mapping test (MMT) to identify eccentric fixation with preferred retinal loci (PRL). Retrospective observational case series from archived data. Cases with age-related macular degeneration with low vision in both eyes and best corrected visual activity (BCVA) of 20/50 to 20/400 in the better ...
Yannuzzi Lawrence A - - 2012
Eleven patients, 40 to 71 years old, had a choroidal vasculopathy that led to hemorrhagic and exudative macular degeneration. The patients had peculiar polypoidal, subretinal, vascular lesions associated with serous and hemorrhagic detachments of the retinal pigment epithelium. This macular disorder, which we have named idiopathic polypoidal choroidal vasculopathy (IPCV), ...
Damico Francisco Max - - 2012
Emerging treatments for dry age-related macular degeneration (AMD) and geographi c atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuroprotection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. Neuroprotective drugs, such as ciliary neurotrophic ...
Satake Masahiro - - 2012
Human T-cell leukemia virus type-1 (HTLV-1), a major source of adult T-cell leukemia and related diseases, is endemic to southwestern Japan. Mother-to-infant transmission via breast milk is an important route of infection, and establishing programs to prevent such transmission requires exact figures on the HTLV-1 prevalence rate and the number ...
Hunter Jessica Ezzell JE Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, - - 2012
To capture the neuropsychological profile among male carriers of the FMR1 premutation allele (55-200 CGG repeats) who do not meet diagnostic criteria for the late-onset fragile X-associated tremor/ataxia syndrome, FXTAS. We have initiated a multicenter collaboration that includes 3 independent cohorts, totaling 100 carriers of the premutation and 216 noncarriers. ...
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