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Mandal Pravat K - - 2011
Glutathione (GSH) serves as an important anti-oxidant in the brain by scavenging harmful reactive oxygen species that are generated during different molecular processes. The GSH level in the brain provides indirect information on oxidative stress of the brain. We report in vivo detection of GSH non-invasively from various brain regions ...
Venkateshappa C - - 2011
Parkinson's disease (PD) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (SN) of the ventral mid brain leading to dopamine depletion in the striatum. Oxidative stress and mitochondrial damage have been implicated in the death of SN neurons during the evolution of PD. In ...
Motawi Tarek K - - 2011
This study investigates the effect of aminoguanidine (AG), a selective inducible nitric oxide synthase (iNOS) inhibitor, and pentoxifylline (PTX), a tumour necrosis factor-alpha (TNF-α) inhibitor, on lipopolysaccharide (LPS)-induced cardiac stress. Rats were divided into four groups: group I served as a control, group II (LPS) received a single intraperitoneal injection ...
Knott Katrina K - - 2011
We examined biomarkers of selenium status (whole blood Se; serum Se; glutathione peroxidase activity) and thyroid status (concentrations and ratios of thyroxine, T4; tri-iodothyronine, T3; albumin) in polar bears to assess variations among cohorts, and relationships to circulating concentrations of contaminants. Concentrations of total mercury (Hg) in whole blood were ...
Arzate-Cárdenas Mario Alberto - - 2011
Daphnia schodleri is a naturally occurring cladoceran in Mexican freshwater bodies and its relative big size and short life cycle allow its use in toxicological bioassays. Generally, life stages at opposite sides of a normal distribution are considered to be the most susceptible and/or sensitive because of several sub-individual level ...
Hadzi-Petrushev Nikola - - 2011
In the present study, we investigated both the age- and heat exposure-related redox changes of blood plasma by analyzing GSH, thiol status and carbonyl groups. Our results clearly indicated that the plasma redox balance shifted toward oxidation during both aging and acute heat exposure. To further confirm this age- and ...
Amato Elvio - - 2011
In the present work, we describe a simple procedure to produce biomimetically coated silver nanoparticles (Ag NPs), based on the postfunctionalization and purification of colloidal silver stabilized by citrate. Two biological capping agents have been used (cysteine Cys and glutathione GSH). The composition of the capped colloids has been ascertained ...
Fabian Elisabeth - - 2011
Eur J Clin Invest 2011 ABSTRACT: Background  Since oxidative stress might cause and promote cardiovascular risk factors such as oxidized low-density lipoproteins (oxLDL), apolipoprotein(a) [apo(a)], asymmetric dimethylarginine (ADMA) and fetuin A, we investigated antioxidant enzyme activities in relation to the vascular redox balance and these risk factors in elderly people. ...
Powe Camille E - - 2011
Studies examining the relationship between total circulating 25-hydroxyvitamin D [25(OH)D] levels and bone mineral density (BMD) have yielded mixed results. Vitamin D-binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D. We hypothesized that free and bioavailable 25(OH)D, calculated from total 25(OH)D, ...
Denniss Steven G - - 2011
The role of the anti-oxidant glutathione (GSH) in mediating endothelial (dys)function, and how that role may depend on age, is unclear. The main purpose of the current study was to investigate the effect of 10d treatment with the GSH-depleting drug L-buthionine sulfoximine (BSO) on endothelium-derived relaxing (EDRF) and contracting (EDCF) ...
Kaushal Deepti - - 2011
The potential benefiting effects of probiotic Dahi on age-inflicted accumulation of oxidation products, antioxidant enzymes and expression of biomarkers of ageing were evaluated in mice. Probiotic Dahi were prepared by co-culturing in buffalo milk (3% fat) Dahi bacteria (Lactococcus lactis ssp. cremoris NCDC-86 and Lactococcus lactis ssp. lactis biovar diacetylactis ...
Torres Larissa Lobo - - 2011
Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative stress in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to investigate plasma production of the lipid peroxidation marker, malonaldehyde (MDA) ...
Nowak Madeleine - - 2011
We measured serum 25 hydroxyvitamin D [25(OH)D] levels of ambulatory adults in tropical Australia to determine whether it is appropriate to continue promoting sun-safety in this population. In August 2006 (winter), self-administered questionnaires were completed by 145 Meals-on-Wheels volunteers (49.3% male; mean age 57.8±14.7 years; 76.6% response) from Townsville, Queensland ...
Mutti Donald O - - 2011
Epidemiologic evidence indicates that time outdoors reduces the risk of myopia, suggesting a possible role for vitamin D. This case-control study was conducted to determine whether single-nucleotide polymorphisms (SNPs) within VDR at 12q13.11 and GC at 4q12-13 are associated with myopia. The primary analysis was conducted on 81 white adult ...
Valezi Antonio Carlos - - 2011
To evaluate the oxidative stress and inflammatory markers in obese patients before and after Roux-en-Y vertical banded gastroplasty. We studied 20 class III obese patients undergoing Roux-en-Y vertical banded gastroplasty, seven men and 13 women, mean age 39 years, and 20 non-obese subjects, nine males and 11 females, mean age ...
Beauchet O O Department of Internal Medicine and Geriatrics, Angers University Hospitals, 49933 Angers cedex 9, France. - - 2011
Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged ...
Ross A Catharine - - 2011
The Institute of Medicine Committee to Review Dietary Reference Intakes for Calcium and Vitamin D comprehensively reviewed the evidence for both skeletal and nonskeletal health outcomes and concluded that a causal role of calcium and vitamin D in skeletal health provided the necessary basis for the 2011 Estimated Average Requirement ...
Hyppönen Elina - - 2011
High vitamin D intake in childhood has been suggested to have an adverse influence on linear growth. In Finland, in the mid-1960s the official recommendation for infant vitamin D supplementation was 2000 iu/d (50 μg/d). We investigated whether high-dose vitamin D supplementation in infancy was associated with subsequent growth in ...
Pérez-López Faustino R - - 2011
BACKGROUND: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism. OBJECTIVE: To review the influences of vitamin D on the aging ...
Schierbeck Louise Lind - - 2011
AIMS: To investigate levels of vitamin D and parathyroid hormone (PTH) in a population of heart failure (HF) patients, and to evaluate whether vitamin D and PTH are related to prognosis. METHODS AND RESULTS: This was a prospective study of 148 HF outpatients (mean age 68 years, 102 men) with ...
Sambrook P N - - 2011
Sunlight exposure by improving vitamin D status could be a simple public health strategy in reducing falls among frail elder people. In a randomised controlled trial, adherence to sunlight exposure was low (median adherence, 26%) and no effect of increased UV exposure on falls risk was observed (incidence rate ratio ...
McNeill G - - 2011
Background/Objectives:Cross-sectional and longitudinal studies provide some evidence for an association between intake of antioxidants and B vitamins, and cognitive function in later life, but intervention studies have not provided clear evidence of beneficial effects. The possibility that those with higher cognitive ability during earlier adult life consume more nutrient-rich diets ...
Houston Denise K DK Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157-1207, USA. - - 2011
Vitamin D deficiency is common among older adults and is associated with poor physical performance; however, studies examining longitudinal changes in 25-hydroxyvitamin D (25[OH]D) and physical performance are lacking. We examined the association between 25(OH)D and physical performance over 12 months in older adults participating in the Lifestyle Interventions and ...
Hemilä Harri - - 2011
BACKGROUND: antioxidants might protect against oxidative stress, which has been suggested as a cause of aging. METHODS: the Alpha-Tocopherol-Beta-Carotene (ATBC) Study recruited males aged 50-69 years who smoked at least five cigarettes per day at the baseline. The current study was restricted to participants who were followed up past the ...
Kalichman Leonid - - 2011
The aim is to evaluate the association between the serum level of vitamin D and prevalence and severity of radiographic hand OA. The study population comprised Chuvashians (91 men with a mean age of 46.24 (20-75) and 99 women with a mean age of 44.94 (18-74)). OA was evaluated for ...
Perlstein Todd S - - 2011
Anemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We utilized the Third National Health and Nutrition Examination Survey (NHANES III) to examine the association of vitamin D deficiency with ...
Emir Uzay E UE Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. - - 2011
In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double-edited (1)H MRS at 4 T in the occipital cortex of healthy young [age (mean ± standard deviation) = 20.4 ± 1.4 years] and elderly (age = 76.6 ± 6.1 years) human subjects. Elderly subjects had a ...
Miljkovic Iva I Department of Epidemiology, Graduate School of Public Health, Pittsburgh, University of Pittsburgh, PA 15213, USA. - - 2011
Vitamin D deficiency is highly prevalent worldwide, and is linked to several major chronic, inflammatory and autoimmune diseases. Vitamin D deficiency has not been evaluated in dark skinned individuals living in areas of high sun exposure utilizing more reliable mass spectrometry assay techniques. We determined the prevalence of 25-hydroxyvitamin D ...
Formiga F - - 2011
Objectives: To calculate the prevalence of hypovitaminosis D in subjects aged 85 years old and to study the relationship between some common geriatric evaluation scales and vitamin D status. Design: Prospective cohort study. Setting: A community-based study. Participants: 312 subjects aged 85 years old. Measurements: Geriatric assessment was based on ...
Robillard Julie M - - 2011
Glutathione (GSH), the major endogenous antioxidant produced by cells, can modulate the activity of N-methyl-D-aspartate receptors (NMDARs) through its reducing functions. During aging, an increase in oxidative stress leads to decreased levels of GSH in the brain. Concurrently, aging is characterized by calcium dysregulation, thought to underlie impairments in hippocampal ...
Rybka Joanna - - 2011
Oxidative stress has been reported to increase with aging. Oxidative stress is also associated with hypertension, and antioxidant treatment has been shown to enhance antioxidant defense system. We therefore aimed to analyze the relationship between aging and some markers of oxidative stress in elderly patients with essential hypertension compared with ...
Yildirim Zuhal - - 2011
To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and ...
Patel Zamip P - - 2011
Male infertility assessment is more than a semen analysis. By interpreting a semen analysis, clinicians recognize its uses and limitations. Once understood, clinicians can then apply modern techniques of endocrine and radiologic evaluation to diagnosis of male reproductive dysfunction. It is important to identify patients with infertility not only to allow ...
Choi Han Seok - - 2010
Context: Vitamin D status in the Korean population has not been adequately determined. Objective: To investigate the vitamin D status and the prevalence of vitamin D insufficiency in the Korean population, and also identify the predictors for vitamin D insufficiency in Korea. Design and Setting: The Fourth Korea National Health ...
Akanji A O - - 2010
BACKGROUND & AIMS: Elevated circulating fasting total homocysteine (tHcy) concentration is associated with an increased risk of occlusive vascular disease in adults. Important determinants of tHcy levels are folate, vitamin B(12) and vitamin B(6). This study aimed to investigate age, gender, and body mass as determinants of folate, vitamin B(12) ...
González-Molero I - - 2010
Background:Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants.Objective:To study the population concentrations of vitamin D in a representative sample of the Spanish population.Subjects/Methods:The study involved two cohorts from ...
McDowell Tzu-Yun - - 2011
Background: Current evidence suggests that sun exposure and vitamin D intake, during childhood and adolescence, are associated with a reduced risk of multiple sclerosis (MS). However, the role of these environmental agents in the timing of disease symptom onset remains to be investigated. Methods: Using a cross-sectional study design, we ...
Selhub Jacob - - 2010
Deficiencies of the vitamins folate, B(12) , and B(6) are associated with neurological and psychological dysfunction and with congenital defects. In the elderly, cognitive impairment and incident dementia may be related to the high prevalence of inadequate B vitamin status and to elevations of plasma homocysteine. Plausible mechanisms include homocysteine ...
Li Fei - - 2011
Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. ...
Oren Yael - - 2010
Hypovitaminosis D has been shown to be extremely common in various regions around the world, mostly at high latitudes. Israel is characterized by certain features--cultural (e.g., ethnic isolates) and geographic (e.g., sunny climate)--that have been identified for their possible association with vitamin D status. To conduct an ecological study on ...
Ross A Catharine - - 2011
This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population needs for these nutrients in North America conducted a comprehensive review of the evidence for both skeletal and extraskeletal outcomes. The ...
Riggs Damien W - - 2011
Although ongoing legislative changes are important to protect the rights of all involved in assisted reproductive technologies, it cannot be guaranteed that legislation will ensure the successful operation of reproductive health clinics, as is indicated by ongoing reports of a dearth of donor sperm in clinics in some countries. Data ...
Nazemian Zohreh - - 2011
The negative correlation between fecundity and age in women has been extensively documented although data on reproductive performance in very young women is sparse. The objective of this study was to determine whether age ≤25 years has an impact on reproductive outcome in women undergoing IVF-ET. IVF outcome in 85 ...
Sud Sohil R - - 2010
Vitamin D (VitD) levels in older Mayans are currently unknown. Geographic factors, for example, residences in areas receiving ample sunlight at high altitudes and latitudes near the equator, would favor optimum VitD levels, whereas demographic factors, for example, darker skin pigmentation, clothing practices, and older age, would favor low 25-hydroxy-vitamin ...
Martí J I - - 2011
The importance of understanding the sperm changes after the cryopreservation process has been emphasized in human and veterinary andrology. In previous studies, we have shown that the morphometric characteristics assessed by computer-assisted analysis following the freeze-thawing process revealed differences in terms of dimension and shape between individuals that may be ...
Agarwal Rachna - - 2010
Vitamin B(12) and folate represent modifiable risk factors for dementia. They may increase the risk of Alzheimer's dementia (AD) and vascular dementia (VaD) as their deficiency can increase the homocysteine level due to slowed methylation reaction. Homocysteine has a neurotoxic effect that could lead to neurologic disturbances. Hence, it is ...
Cabrita E - - 2011
Improving fertilization success in captive Senegalese sole broodstocks has been a challenge in the last years. Recent reports suggest that low sperm volume and quality could be one of the reasons leading to poor fertilization rates, although further studies are needed to reach a conclusive explanation. Here, we report on ...
Carvalho J O - - 2010
The objective was to evaluate the structural and functional quality of bull sperm after sexing by flow cytometry. Frozen non-sexed (NS), sexed for X (SX) and sexed for Y (SY) sperm from four bulls was used. Frozen-thawed sperm was analyzed for motility, sperm head agglutination, morphology, capacitation, and integrity of ...
Desai Sonalde S Department of Sociology, University of Maryland, 2112 Art-Sociology Building, College Park, MD 20742, USA. - - 2010
Research on marriage in developing countries has been somewhat narrow in scope because of both conceptual and data limitations. While the feminist literature recognizes marriage as a key institutional site for the production and reproduction of gender hierarchies, little is known about the processes through which this relationship operates. This ...
Uneke C J - - 2010
Male factors are known to contribute significantly to the infertility problem. The urogenital bacteria profile and semen quality were investigated among 160 men attending infertility clinics in South-eastern Nigeria. Both semen and urine samples were obtained from each subject and analysed according to standard techniques. A total of 16 (10%) ...
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