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Silverberg Jonathan I JI Departments of Dermatology, Preventive Medicine, and Medical Social Sciences, Northwestern University, Chicago, Ill; Department of Dermatology, Beth Israel Medical Center and St Luke's-Roosevelt Hospital Center, New York, NY. Electronic address: - - 2014
Climate factors and pollen counts may play a role in hay fever. We sought to determine the impact of specific climate factors and pollen counts on the US prevalence of hay fever and statewide variation in prevalence. We used a merged analysis of the 2007 National Survey of Children's Health ...
Altarescu Gheona G Genetics Unit, Shaare Zedek Medical Center, affliated with the Hadassah-Hebrew University Medical School, Jerusalem, - - 2014
Mutations in β-glucocerebrosidase, the genetic defect in Gaucher disease (GD), are an important susceptibility factor for Parkinson disease (PD). A PD effector is α-synuclein (SNCA) hypothesized to selectively interact with β-glucocerebrosidase under lysosomal conditions. SNCA polymorphism rs356219 may be associated with early-age-onset PD, common among patients with GD+PD. The objective ...
Levi-Zada Anat A Department of Entomology, Agricultural Research Organization, Volcani Center, Bet-Dagan, 50250, Israel, - - 2014
The diel periodicity of sex pheromone release was monitored in two mealybug species, Planococcus citri and Planococcus ficus (Hemiptera; Pseudococcidae), using sequential SPME/GCMS analysis. A maximal release of 2 ng/h pheromone by 9-12-day-old P. citri females occurred 1-2 h before the beginning of photophase. The highest release of pheromone by P. ficus ...
Setyawati Magdiel Inggrid MI Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, - - 2014
How silver nanomaterials (Ag NMs) could induce toxicity has been debated heatedly by many researchers. We utilized Ag nanoclusters (Ag NCs) with the same size and ligand protection but different core surface speciation. Ag(+)-rich NCs (Ag(+)-R NCs) and their counterpart, the reduced Ag(0)-rich NCs (Ag(0)-R NCs) are synthesized to represent ...
Liu Jun-Ping JP Institute of Ageing Research, School of Medicine, Hangzhou Normal University, 311121, Zhejiang, China; Department of Immunology, Monash University Central Clinical School, 3181, Prahran, Victoria, Australia; Department of Genetics, Faculty of Science, University of Melbourne, 3010, Parkville, Victoria, - - 2014
Human and other multi-cellular life species age and the aging processes become dominant in a late phase of lives. However, recent studies challenged the dogma suggesting that ageing in some animal species may never occur, but mammals undertake cell replicative senescence as early as before birth in embryos under physiological ...
Menter Thomas T Institute of Pathology, University Hospital, Basel, - - 2014
There is an increased susceptibility and mortality in the elderly due to pneumonia caused by Streptococcus pneumoniae. We aimed to assess the inflammatory cell composition with respect to age in pneumococcal pneumonia patients. Neutrophilic granulocytes and various lymphocyte and macrophage subpopulations were immunohistochemically quantified on lung tissue specimens of young ...
Tigges Julia J Leibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, - - 2014
Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage ...
San Román-Monserrat Irene I Servicio de Medicina Interna, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain. Electronic address: - - 2014
Fabry disease is an X-linked multisystemic lysosomal-storage condition. We describe a large family with a novel GLA mutation: p.M187R/g7219 T>G. Anamnesis/physical-exam, blood/urine analysis, α-Gal-A activity and/or genetic study of at-risk individuals and multidisciplinary evaluation in confirmed cases. 4 males and 13 heterozygous-females displayed the mutation. Cardiac/renal/neurological disease was diagnosed at ...
Lin Hsiang-Yu - - 2014
Mucopolysaccharidosis IVA (MPS IVA) is a rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase deficiency, which catalyzes a step in the catabolism of glycosaminoglycans, keratan sulfate and chondroitin-6-sulfate. This disease has a variable age of onset and rate of progression. A retrospective analysis of medical records of 24 patients with MPS ...
Crockett Cameron D CD University of Iowa Carver College of Medicine, Iowa City, IA, - - 2014
Introduction: X-linked myopathy with excessive autophagy (XMEA) is characterized by autophagic vacuoles with sarcolemmal features. Mutations in VMA21 result in insufficient lysosome acidification, causing progressive proximal weakness with onset before age 20 and loss of ambulation by middle age. Methods: We describe a patient with onset of slowly progressive proximal ...
Hamilton Raymond F RF Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA. - - 2014
Silver (Ag) nanomaterials are increasingly used in a variety of commercial applications. This study examined the effect of size (20 and 110 nm) and surface stabilization (citrate and PVP coatings) on toxicity, particle uptake and NLRP3 inflammasome activation in a variety of macrophage and epithelial cell lines. The results indicated ...
Miyayama Takamitsu T Research Center for Environmental Risk, National Institute for Environmental - - 2014
  Silver nanoparticles (AgNPs) are commercially used mainly as antibacterial reagents in wound dressing and deodorant powders. However, the mechanisms underlying Ag toxicity in mammals are not fully understood. In the present study, we assessed cellular distribution and toxicity of AgNPs and AgNO3 in mouse macrophage cell line (J774.1) and those ...
Sinn David L DL Department of Primary Industries, Parks, Water, & The Environment, Hobart, Tasmania, Australia; School of Zoology, University of Tasmania, Hobart, Tasmania, Australia; Department of Psychology, University of Texas at Austin, Austin, - - 2013
Translocation of endangered animals is common, but success is often variable and/or poor. Despite its intuitive appeal, little is known with regards to how individual differences amongst translocated animals influence their post-release survival, growth, and reproduction. We measured consistent pre-release responses to novelty in a familiar environment (boldness; repeatability = 0.55) and ...
Hsu Chin-Yuan CY Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan. Electronic address: - - 2013
The trophocytes and fat cells of honeybees (Apis mellifera) have been used in cellular senescence studies, but the changes of cellular degradation activity with aging in workers is unknown. In this study, cellular degradation activity was evaluated in the trophocytes and fat cells of young and old workers reared in ...
Tashiro Kanae - - 2013
Autophagy is an intracellular degradative system that is believed to be involved in the aging process. The contribution of autophagy to age-related changes in the human skin is unclear. In this study, we examined the relationship between autophagy and skin aging. Transmission electron microscopy and immunofluorescence microscopy analyses of skin ...
Brand Guilherme Dotto - - 2013
High-throughput mass spectrometry methods have been developed to screen newborns for lysosomal storage disorders, allowing the implementation of newborn screening pilot studies in North America and Europe. It is currently feasible to diagnose Pompe, Fabry, Gaucher, Krabbe, and Niemann-Pick A/B diseases, as well as mucopolysaccharidosis I, by tandem mass spectrometry ...
de Ruijter J - - 2013
Mucopolysaccharidosis III (MPS III), known as Sanfilippo disease, is a lysosomal storage disorder mainly characterized by progressive neurodegeneration with cognitive decline and relatively attenuated somatic signs and symptoms. Although short stature is invariably present in patients with the other mucopolysaccharidoses, it has not been sufficiently addressed in MPS III. The ...
Pyo Jong-Ok JO Bio-MAX Institute, Seoul National University School of Biological Sciences, Seoul, - - 2013
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced ...
Zhao Hui H Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, - - 2013
We examined the effect of aging on Fas ligand (FasL) function in a mouse model of choroidal neovascularization (CNV). Young and aged mice were laser treated to induce CNV. Bone marrow chimeras were performed between young and aged mice. FasL protein expression was examined in the eye and soluble FasL ...
Mohamed Nur-Ezan - - 2013
Dementia with Lewy bodies and Parkinson's disease dementia are different clinical phenotypes of Lewy body dementias differentiated by the temporal relationship between parkinsonism and dementia onset. At present, it is unclear whether the glutamatergic system is affected in these disorders. In this study, we measured α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA subunits ...
Sabharwal Sanjeev - - 2013
: Children with Blount disease are often obese and have muliplanar limb deformities including leg length discrepancy. Surgical options for these skeletally immature patients include guided growth and realignment osteotomy. Suboptimal outcomes such as persistent valgus overcorrection after proximal tibial osteotomy in children with early-onset Blount disease and undercorrection after ...
Nosaka Mizuho - - 2013
We immunohistochemically examined the expression of IFNγ, TNFα, and TNF receptor p55 (TNF-Rp55) in a stasis-induced venous thrombus murine model. IFNγ(+), TNFα(+), and TNF-Rp55(+) cells could be first detected 7, 3, and 3 days after inferior vena cava (IVC) ligation. Thereafter, the numbers of these positive cells increased with time after ...
Rodríguez-Muela Natalia N Department of Cellular and Molecular Biology, CIB, CSIC, Ramiro de Maeztu 9, E-28040, Madrid, - - 2013
Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged-related macular degeneration, major cause of blindness in the elderly population. Accumulation of undegraded material as lipofuscin represents a hallmark in many pathologies of the aged eye. Autophagy is a highly conserved intracellular degradative pathway ...
Guan Jing-Zhi - - 2013
Telomere attrition proceeds with the aging process, and is also associated with aging disease conditions, such as Alzheimer's disease (AD). The aging process also affects subtelomeric methylation status. In the present study, the telomere length and the subtelomeric methylation status in female AD patients were analyzed to see how AD ...
Nauta Ferdau L FL Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The - - 2013
Albuminuria is associated with risk for renal and cardiovascular disease. It is difficult to predict which persons will progress in albuminuria. This study investigated whether assessment of urinary markers associated with damage to different parts of the nephron may help identify individuals that will progress in albuminuria. Individuals were selected ...
Janson David - - 2013
Serial passaging has a profound effect on primary cells. Since serially passaged cells show signs of cellular aging, serial passaging is used as an in vitro model of aging. To relate the effect of in vitro aging more to in vivo aging, we generated human skin equivalents (HSEs). We investigated ...
Rodrigues Jorge - - 2013
Green tea (GT) displays strong anti-oxidant and anti-inflammatory properties mostly attributed to (-)-epigallocatechin-3-gallate (EGCG), while experiments focusing on other catechins are scarce. With the present work we intended to analyze the neuroprotective effects of prolonged consumption of a GT extract (GTE) rich in catechins but poor in EGCG and other ...
Kim Su Kyoung - - 2013
Hatchery seeds released into open coasts for wildstock enhancement are often a biological pollutant and affect the recipient ecosystem integrity. We studied morphological changes in two hatchery populations of the starry flounder Platichthys stellatus; one released into the open coast from the hatchery (released population) and the other kept in ...
Wen Yan Y Department of Obstetrics/Gynecology, Stanford University School of Medicine, Stanford, California 94305-5317, USA. - - 2013
We aimed to derive induced pluripotent stem cell (iPSC) lines from vaginal fibroblasts from older women with pelvic organ prolapse. We examined the effect of donor age on iPSCs and on the cells redifferentiated from these iPSCs. Vaginal fibroblasts were isolated from younger and older subjects for reprogramming. iPSCs were ...
Chen Jianchun J Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, - - 2013
Recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of podocytes. The mammalian homologue of yeast vacuolar protein sorting defective 34 (mVps34) has been implicated in the regulation of autophagy, but its role in podocytes is unknown. We generated a line of podocyte-specific mVps34-knockout (mVps34(pdKO)) ...
Salvioli Stefano - - 2013
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, ...
Torres Manuel - - 2012
ABSTRACT: BACKGROUND: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also ...
Kaarniranta Kai - - 2012
Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly in the developed countries. The number of AMD patients will double during the next decades due to increasing number of aged people. Chronic oxidative stress, inflammation and accumulation of protein-rich deposits both in the retinal ...
Salvioli Stefano - - 2012
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, ...
Pata Giacomo - - 2012
BACKGROUND: We aimed to evaluate risk factors for postoperative complications after total gastrectomy with "over-D1" lymphadenectomy. METHODS: Data on 161 patients (54 cases aged >75 years: elderly group) operated on between 2005 and 2011 were reviewed. Risk factors analyzed for complications (Clavien-Dindo classification) included sex, age, American Society of Anesthesiologists ...
Nowaczyk Piotr - - 2012
The aim of the study was to assess sentinel lymph node biopsy (SLNB) results in colon cancer (CC) regarding basic anthropometric features of the studied population and their derivatives calculated using mathematical formulas. One hundred three SLNBs in CC have been analysed. Various indicators were calculated for every patient using ...
Masterson Timothy A - - 2012
Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The effect of advancing age on the clinicopathological outcomes of men with germ cell testicular cancers remains uncertain. Through the review and comparison of the present large cohort of men ...
Boukens Bastiaan J - - 2012
The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus node affects many people later in life, causing physiologically inappropriate heart rates, but the underlying ...
Hirano Shigeru - - 2012
OBJECTIVES/HYPOTHESIS: Aged vocal folds are characterized by atrophy of the mucosa, which causes mucosal wave deficiency and glottal insufficiency. This clinical trial examined the regenerative effects and safety considerations of basic fibroblast growth factor (bFGF) on restoration of aged vocal folds. STUDY DESIGN: Institutional review board-approved human clinical trial. METHODS: ...
Cossar Roisin - - 2012
PURPOSE:  This essay examines the human experience of aging in the distant past by investigating a group of aging men during the 14th century in an Italian city, Bergamo, using notarial "documents of practice" from that community. Studying the aging process and its effects on the lives of people in ...
Page A J - - 2012
Background. Advanced age is associated with a poorer prognosis in patients with melanoma. Despite this established finding, a decreased incidence of positive sentinel lymph nodes (SLNs) with advancing age has paradoxically been described. Methods. Using a single-institution database of melanoma patients between 1994 and 2009, the relationship between standard clinicopathologic ...
Ratts Robert B - - 2012
Age-associated decline of immune function is believed to be mainly due to alterations of immune cells. However, longitudinal changes of human immune cells with age have not yet been adequately addressed. To test the hypothesis that regeneration of lymphocytes and monocytes is robust throughout most of adult life until advanced ...
Bennett Dimitri - - 2011
INTRODUCTION: Data regarding the prevalence of immune thrombocytopenia (ITP) is limited, and is derived from North American population-based analyses. Therefore, the authors conducted the first study outside the United States (US) using the United Kingdom (UK) General Practice Research Database (GPRD) to estimate the adult prevalence of ITP in the ...
Loeb Gregory M - - 2011
For some Lepidopteran pests, such as the grape berry moth Paralobesia viteana (Clemens), poor correlation between males captured in traps baited with sex pheromone and oviposition activities of female moths has called into question the value of pheromone-based monitoring for these species. As an alternative, we compared the capture of ...
Schwarz Karine - - 2011
The paralyzed vocal fold positioning and the degree of dysphonia are important inputs when one is deciding upon treatment options for unilateral vocal fold paralysis (UVFP). OBJECTIVE: To check voice characteristics and paralyzed vocal fold position in men with UVFP. MATERIALS AND METHODS: This is a retrospective historical cross-sectional cohort ...
Listl Stefan - - 2011
Gerodontology 2011; doi: 10.1111/j.1741-2358.2011.00590.x Income-related inequalities in denture-wearing by Europeans aged 50 and above Background:  Despite its importance for the planning of future treatment needs and an optimised allocation of health care resources, only little is known about socio-economic inequalities in denture-wearing by late middle-aged and elderly generations. Objectives:  To ...
Duke J - - 2011
BACKGROUND: This study presents a 26-year epidemiological assessment of burn injury hospitalisations for people 15-29years of age in Western Australia. METHODS: Linked hospital morbidity and death data for all persons hospitalised with an index burn injury in Western Australia for the period 1983-2008 were analyzed. Annual age-specific incidence rates were ...
Hamdan Abdul-latif - - 2012
To determine the effect of a Mediterranean tongue trill (Zalghouta) on estimated glottal closed quotient (CQ). A total of 10 female subjects participated in this study. Vocal fold CQ was measured for both sustained vowel [a] and the tongue trill named Zlaghouta using electroglottography. Frequencies and means (±standard deviation) were ...
Quaio C R D C - - 2012
Hunter syndrome, or Mucopolysaccharidosis type II (MPS II), is a rare X-linked recessive disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS). The phenotypic spectrum varies from severe to attenuated clinical forms. We report a large Brazilian family with 16 affected individuals exhibiting a very attenuated form of ...
Sheppard Jeremy M - - 2011
Several investigations have demonstrated differences in anthropometry, jump performance, and strength variables between developmental and elite level volleyball players. However, within the elite level of play, the magnitude of change that can occur with training is unclear. The purpose of this investigation was to examine the anthropometric, vertical jump, and ...
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