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Stone Jonathan J Bosch Institute, Sydney, Australia Disciplines of Physiology, Sydney, - - 2014
This review traces evidence that age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral ...
Kumral Bahadir B From the *Department of Forensic Medicine, Namik Kemal University, Faculty of Medicine, Tekirdag; †Department of Forensic Medicine, Abant İzzet Baysal University, Faculty of Medicine, Bolu; ‡Department of Forensic Medicine, Kahramanmaras Sutcu İmam University, Faculty of Medicine, Kahramamaras; §The Ministry of Justice, Council of Forensic Medicine, Istanbul, - - 2014
Hanging is a type of strangulation by means of rope or any other similar material. This kind of ligature strangulation occurs by weight of the body dragging due to gravity and applying force to the neck. Hanging almost never occurs by accident, but occurs mostly as a way to commit ...
Rudd Rose A - - 2014
Nationally, death rates from prescription opioid pain reliever (OPR) overdoses quadrupled during 1999-2010, whereas rates from heroin overdoses increased by <50%. Individual states and cities have reported substantial increases in deaths from heroin overdose since 2010. CDC analyzed recent mortality data from 28 states to determine the scope of the ...
Wingren Carl Johan CJ Department of Forensic Medicine in Lund, The National Board of Forensic Medicine, Sölvegatan 25, SE-223 62 Lund, Sweden; Unit for Forensic Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. Electronic address: - - 2014
Obesity is a global problem and in aspects of lethal ethanol intoxications virtually unexplored. The cause of death in ethanol intoxication is generally considered to be suppression of the respiratory function. Previous research indicates that respiratory function is more vulnerable in obese subjects than in those of normal weight. We ...
Norheim Ole F OF Department of Global Public Health and Primary Care, University of Bergen, Norway. Electronic address: - - 2014
The UN will formulate ambitious Sustainable Development Goals for 2030, including one for health. Feasible goals with some quantifiable, measurable targets can influence governments. We propose, as a quatitative health target, "Avoid in each country 40% of premature deaths (under-70 deaths that would be seen in the 2030 population at ...
Mokdad Ali A AA Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. - - 2014
Liver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors such as alcohol use and hepatitis B and C infection. We estimated annual age-specific mortality from liver cirrhosis in 187 ...
Vardoulakis Sotiris S Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, U.K.; National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia; and Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, - - 2014
Background: High and low ambient temperatures are associated with increased mortality in temperate and subtropical climates. Temperature related mortality patterns are expected to change throughout this century due to climate change. Objectives: We compared mortality associated with heat and cold in UK regions and Australian cities for current and projected ...
Melaku Yohannes Adama - - 2014
In developing countries, investigating mortality levels and causes of death among all age female population despite the childhood and maternal related deaths is important to design appropriate and tailored interventions and to improve survival of female residents. Under Kilite-Awlealo Health and Demographic Surveillance System, we investigated mortality rates and causes ...
Baig Ulfat I - - 2014
Several unresolved issues, paradoxes, and information voids characterize the field of evolution of aging. The recent discovery of aging-like phenomenon in Escherichia coli, marked by asymmetric segregation of damaged components, particularly protein aggregates, has created a number of new possibilities that remain underexplored. Bacterial systems can potentially throw light on ...
Hutchinson John P JP University of Nottingham, Epidemiology and Public Health, Nottingham, United Kingdom ; - - 2014
Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited. Objectives: We aimed to collate death certification data from multiple countries to determine global trends in mortality from idiopathic pulmonary fibrosis. Methods: Data were obtained ...
Deevska Gergana G University of Kentucky, United - - 2014
In hepatocytes, aging-associated decline in GSH has been linked to activation of neutral sphingomyelinase (nSMase), accumulation of bioactive ceramide and inflammation. In this study, we seek to test whether dietary supplementation with cysteine precursor, L-2-Oxothiazolidine-4-carboxylic acid (OTC), would correct the aging-associated differences in hepatic GSH, nSMase, and ceramide. Young and ...
Straif-Bourgeois Susanne S School of Public Health at Louisiana State University Health Sciences Center in New - - 2014
This report is a purely descriptive study of firearm-related deaths occurring in Louisiana from 1999 to 2010. Mortality data were collected from death certificates from this 12-year period to describe firearm fatalities by year, race, gender, age group, and manner of death (accident, homicide, suicide). Louisiana data were also compared ...
Finsterer Josef - - 2014
Recurrent vomiting due to bulimia associated with abuse of furosemide and laxatives causing severe hypokalemia may result in recurrent aborted sudden cardiac death (SCD) and seizures. We report a 25-year-old female with a history of bulimia associated with abuse of furosemide and laxatives since the age of 15 years, migraine ...
Coban Jale J Department of Biochemistry, Yeditepe University Medical Faculty, Istanbul, - - 2014
Olive leaf (Olea europaea L.) extract (OLE) is a powerful anti-oxidant rich in polyphenols. As oxidative stress plays an important role in aging, we investigated the effect of OLE on oxidative stress in the liver, heart and brain of aged rats. Young (age 3 months) and aged (age 20 months) ...
Tong Haiyan H Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park , NC , USA - - 2014
Abstract Context: Epidemiological studies have shown an association between the incidence of adverse cardiovascular effects and exposure to ambient particulate matter (PM). Diesel exhaust (DE) is a major contributor to ambient PM and gaseous emissions in urban areas. Objective: This was a pilot study designed to evaluate concentration-dependent effects of ...
Cho Eun-Min EM Kyung Hee University, College of Environment and Applied Chemistry, Yongin 446-701, Republic of - - 2014
Surface-enhanced Raman scattering (SERS) of an antifungal reagent, myclobutanil (MCB), was performed on Au and Ag nanoparticles (NPs) to estimate the drug-release behaviors in fungal cells. A density functional theory (DFT) calculation was introduced to predict a favorable binding site of MCB to either the Ag or Au atom. Myclobutanil ...
Pandey Ashutosh A Embryotoxicology Section, CSIR-Indian Institute of Toxicology Research, Lucknow, 226001, Uttar Pradesh, - - 2014
Dichloroacetic acid (DCA), a water disinfection by-product, has attained emphasis due to its prospect for clinical use against different diseases including cancer along with negative impact on organisms. However, these reports are based on the toxicological as well clinical data using comparatively higher concentrations of DCA without much of environmental ...
Paredes Jamespaul J Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center of Emory University, 954 Gatewood Drive, Atlanta, GA, 30329, USA, - - 2014
Chimpanzee (Pan troglodytes) and rhesus macaque (Macaca mulatta) and humans (Homo sapiens) share physiological and genetic characteristics, but have remarkably different life spans, with chimpanzees living 50-60 % and the rhesus living 35-40 % of maximum human survival. Since oxidative processes are associated with aging and longevity, we might expect to see ...
Balavandy Sepideh Keshan - - 2014
This study aims to investigate the influence of different stirring time for synthesis of silver nanoparticles in glutathione (GSH) aqueous solution. The silver nanoparticles (Ag-NPs) were prepared by green synthesis method using GSH as reducing agent and stabilizer, under moderate temperature at different stirring times. Silver nitrate (AgNO3) was taken ...
Henrie James - - 2014
Terror Management Theory (TMT) (Greenberg, Pyszczynski, & Solomon, 1986) suggests that culturally-provided worldviews (e.g., religion) may protect individuals from experiencing death anxiety, and several studies have supported this position. However, if one's worldview can offer protection, doubts concerning one's worldview could undermine this protection. The current study investigated whether age, ...
Renard Françoise F Department Public Health and Statistics, Institute of Public Health, Brussels, - - 2014
Reducing premature mortality is a crucial public health objective. After a long gap in the publication of Belgian mortality statistics, this paper presents the leading causes and the regional disparities in premature mortality in 2008-2009 and the changes since 1993. All deaths occurring in the periods 1993-1999 and 2003-2009, in ...
Mancini Gianni - - 2013
The present work aimed to investigate the effect of (PhSe)2 on cardiovascular age-related oxidative stress in hypercholesterolemic mice. To this end, LDL receptor knockout (LDLr(-/-) ) mice, 3 months (young adult) and 12 months (middle-aged) old, were orally treated with (PhSe)2 . Hypercholesterolemia, regardless of age, impaired the mitochondrial antioxidant ...
Zanobetti Antonella - - 2013
Ambient air pollution has been associated with sudden deaths, some of which are likely due to ventricular arrhythmias. Defibrillator discharge studies have examined the association of air pollution with arrhythmias in sensitive populations. No studies have assessed this association using residence-specific estimates of air pollution exposure. In the Normative Aging ...
Massarsky Andrey - - 2013
Silver nanoparticles (AgNPs) are present in a multitude of consumer and medical products; however, the toxicity of AgNPs is not fully understood. This research aimed to elucidate the relationship between AgNPs cytotoxicity and oxidative stress and damage in rainbow trout (Oncorhynchus mykiss) hepatocytes and erythrocytes in comparison to silver ions ...
Spina Alexander - - 2013
Recent studies have raised concern over possible associations between high selenium (Se) status and excess adiposity, known to be linked to adverse cardio-metabolic outcomes. Studies of Se status in relation to adiposity are scarce in the UK. This study examined cross-sectional associations of anthropometric indices with Se-status biomarkers in a ...
Negishi Takayuki - - 2013
In Japan, people using water from the well contaminated with high level arsenic developed neurological, mostly cerebellar, symptoms, where diphenylarsinic acid (DPAA) was a major compound. Here, we investigated the adverse effects of developmental exposure to 20 mg/L DPAA in drinking water [early period (0-6 weeks of age) and/or late-period ...
Saha Arindam - - 2013
Glutathione (GSH) and oxidized glutathione (GSSG) controls cellular function and efficiency of anticancer therapy. Reliable detection of cellular GSH/GSSG is challenging due to their ultralow concentration (typically femtomolar concentration) and interference by thiol based other molecules. Here we reports a 'turn-off' SERS based approach for reliable detection of cellular GSH ...
Chitty Kate M - - 2013
Alcohol misuse is highly prevalent in bipolar disorder (BD) and has been associated with increased formation of reactive oxygen species in the CNS. Proton magnetic resonance spectroscopy ((1)H-MRS) is an in vivo tissue-based imaging modality that allows the investigation of changes in the brains primary antioxidant, glutathione (GSH), as a ...
Dragicevic Vesna - - 2013
The 2,4-D (2,4-dichlorophenoxyacetic acid) is using as a growth regulator in tissue culture media. Maize seeds have poor ability to maintain germination rate in the long term. To examine the possible restorative effect of homeopathic 2,4-D potencies on maize seedlings originating from seeds damaged by accelerated aging. Seeds of four ...
Kankofer M - - 2013
Antioxidative/oxidative balance is crucial for proper functioning of cells and tissues. It is suggested that this balance can be partly controlled by sex steroid hormones and in consequence can exhibit age- and sex-related dependency. The aim of present study was to describe sex- and age-related changes in the activity of ...
Brasil Aline A - - 2013
Mutations in Cu,Zn-superoxide dismutase (Sod1) have been associated with familial amyotrophic lateral sclerosis (FALS), an age-related disease. Since several studies suggest that oxidative stress plays a central role in neurodegeneration, we aimed to investigate the role of the antioxidant glutathione (GSH) in the activation of human A4V Sod1 during chronological ...
Savery Laura C - - 2013
Pollution of the ocean by mercury (Hg) is a global concern. Hg persists, bioaccumulates and is toxic putting high trophic consumers at risk. The sperm whale (Physeter macrocephalus), is a sentinel of ocean health due to its wide distribution, longevity and high trophic level. Our aim was to survey Hg ...
Han Chul C Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32610, - - 2013
Reducing calorie intake extends the lifespan of a variety of experimental models and delays progression of age-related hearing loss (AHL). AHL is a common feature of aging and is characterized by age-related decline of hearing associated with loss of sensory hair cells, spiral ganglion neurons, and/or stria vascularis degeneration in ...
Pan Danzhen - - 2013
The purpose of this study was to assess hair selenium levels of liver patients suffering from hepatic simple steatosis and non-alcoholic steatohepatitis (NASH) in central areas of China. Selenium was measured by an atomic absorption spectrophotometer equipped with the hydride generation system. The levels of selenium in healthy individuals ranged ...
Chen Hongying - - 2013
Understanding of seed ageing, which leads to viability loss during storage, is vital for ex situ plant conservation and agriculture alike. Yet the potential for regulation at the transcriptional level has not been fully investigated. Here, we studied the relationship between seed viability, gene expression and glutathione redox status during ...
Roede James R JR Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, - - 2013
Due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate model of aging. Blood and extracellular fluid possess two major thiol-dependent redox nodes involving cysteine (Cys), cystine (CySS), glutathione (GSH) ...
Yuan Xun - - 2012
The integration of the unique thiol-Ag chemistry and the specific steric hindrance from the organic layer of fluorescent Ag nanoclusters (AgNCs) was first developed in this work to achieve a simple detection of cysteine (Cys) with high selectivity and sensitivity. The key design is a strongly red-emitting AgNC protected by ...
Weiss Norbert - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: Supplementation with Aged Garlic Extract (AGE) has been shown to restore impaired endothelium-dependent vasodilator response in subjects with acutely elevated plasma homocysteine (Hcy) levels after an oral methionine load and in patients with chronic coronary artery disease. Moreover, AGE has been shown to inhibit the progression of coronary ...
Mancinelli E - - 2012
Free-catch urine samples were collected from forty-one clinically normal domestic rabbits of various ages, breeds and both sexes. The Test γ GT Liquid-0018257640 was used for the in vitro quantitative determination of γ-Glutamyl-transferase (GGT) and reference intervals for γ-glutamyl transferase (γ-glutamyl transpeptidase, γ-GT, GGT) and GGT index (γ-glutamyl transferase to ...
Goncharova Nadezhda D - - 2012
We have investigated age-related changes in the reliability of glutathione-related antioxidant enzyme defense in monkeys that differ in adaptive behavior. Activities of gluthatione reductase (GR), glutathione peroxidase (GSH-Px), and gluthatione-S-transferase (GST) and also lipid peroxidation products (TBARS) under basal conditions and under acute psycho-emotional stress were evaluated in erythrocytes of ...
Martino Davide D Department of Neurosciences and Sensory Organs and School of Motor Sciences, Aldo Moro University of Bari, Bari, - - 2012
The site of dystonia onset is known to affect the risk of spread in primary adult-onset focal dystonia, but other factors possibly influencing spread are unknown. This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia. Two survival models analyzed spread of dystonia in ...
Park Hee-Jin - - 2012
The purpose of this study was to evaluate interobserver agreement and whether or not a new MRI grading system correlates with symptoms and neurologic signs for assessing spinal canal compression. One hundred patients (52 men and 48 women; mean age, 50 years) underwent MRI of the cervical spine at our ...
Agrawal Yuri Y Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. - - 2012
To characterize the physiologic nature of the vestibular dysfunction that occurs with the normative aging process. Cross-sectional study. Tertiary care academic medical center. Fifty individuals age 70 years and above. Head thrust dynamic visual acuity testing and cervical and ocular vestibular-evoked myogenic potential (VEMP) testing. Semicircular canal function measured by ...
da Costa Ronaldo C - - 2012
No screening method is currently available to differentiate dogs with and without cervical spondylomyelopathy. Intravertebral and intervertebral ratios are used in horses and can predict cervical vertebral malformation. Intervertebral ratios could be a useful screening method for canine cervical spondylomyelopathy. Our purpose was to compare cervical intervertebral and intravertebral ratios ...
Kelly Marie - - 2012
INTRODUCTION: The Deep Cervical Flexors (DCFs) provide support and segmental stability to the cervical spine. However, their endurance capacity can be reduced in cervicogenic disorders. The Craniocervical Flexion Test (CCFT) is regarded as the most effective means of assessing the contractile performance of these muscles. However, limited normative data exists ...
Abbas Alaa K - - 2012
BACKGROUND We aimed to study the distribution and causes of trauma in women of child-bearing age. METHODS Data were collected from Al-Ain Hospital (United Arab Emirates-UAE) Trauma Registry. Females aged 16 to 45 years (child-bearing age) who were admitted with trauma between March 2003 and March 2006 were included in ...
Matsumoto M - - 2012
We conducted a prospective follow-up MRI study of originally asymptomatic healthy subjects to clarify the development of Modic changes in the cervical spine over a ten-year period and to identify related factors. Previously, 497 asymptomatic healthy volunteers with no history of cervical trauma or surgery underwent MRI. Of these, 223 ...
Lee Tae Hoon - - 2012
The anatomical knowledge is the most important and has a direct link with success of operation in cervical spine surgery. The authors measured various cervical parameters in cadaveric dry bones and compared with previous reported results. We made 255 dry bones age from 19 to 72 years (mean, 42.3 years) ...
Metso Tiina M - - 2012
The goal of this work was to explore age-dependent differences in cervical artery dissection (CeAD). This study is based on the Cervical Artery Dissection and Ischemic Stroke Patients population comprising 983 consecutive CeAD patients and 658 control patients with a non-CeAD ischemic stroke (IS), frequency-matched for age and gender. Patients ...
Bang Ji Young - - 2012
BACKGROUND: The National Health Service Cervical Screening Programme was established to decrease the incidence and mortality of cervical cancer in England. METHODS: To identify socioeconomic and general practice factors associated with cervical screening coverage in England, a national cross-sectional study was conducted using data on 26 497 476 female patients ...
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