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Juozulynas, Algirdas
The aim of the study was a questionnaire-based investigation of the physical and psychological dimensions of health-related quality of life among Lithuanian seamen. Method. The WHOQOL-BRIEF questionnaire, an abbreviated 26-item version of the WHQOL-100, was developed using data from the field-trial version of the WHOQOL-100. The data were analyzed using ...
North Brian J BJ Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, MA, - - 2014
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to underlie normal aging and age-related diseases. Understanding why BubR1 declines ...
Stein Liana R LR Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, - - 2014
Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age. The molecular mechanisms responsible for these declines remain unclear. Here, we show that levels of NAD(+) and nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in mammalian NAD(+) biosynthesis, decrease with age in the hippocampus. Ablation ...
Imai Shin-Ichiro SI Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: - - 2014
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. ...
Kim Hyung-Jin HJ Center for Metabolic Function Regulation & Department of Microbiology, Wonkwang University School of Medicine, 460 Iksan-Daero, Iksan, Jeonbuk, 570-749, - - 2014
Age-related hearing loss (ARHL), a degenerative disorder characterized by age-dependent progressive increase in the threshold of auditory sensitivity, affects 40% of people over the age of 65, and it has emerged as an important social and public health problem. Various factors, including genetic and environmental components, are known to affect ...
Ghosh Debolina D Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, 62794-9626, - - 2014
Aging, a major risk factor in Alzheimer's disease (AD), is associated with an oxidative redox shift, decreased redox buffer protection, and increased free radical reactive oxygen species (ROS) generation, probably linked to mitochondrial dysfunction. While NADH is the ultimate electron donor for many redox reactions, including oxidative phosphorylation, glutathione (GSH) ...
Godoy Juan A JA Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Av. Alameda 340, Santiago, - - 2014
Ageing is a stochastic process associated with a progressive decline in physiological functions which predispose to the pathogenesis of several neurodegenerative diseases. The intrinsic complexity of ageing remains a significant challenge to understand the cause of this natural phenomenon. At the molecular level, ageing is thought to be characterized by ...
Guest Jade J Australasian Research Institute, Sydney Adventist Hospital, Sydney, New South Wales, Australia ; Department of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, - - 2014
An extensive body of evidence indicates that oxidative stress and inflammation play a central role in the degenerative changes of systemic tissues in aging. However a comparatively limited amount of data is available to verify whether these processes also contribute to normal aging within the brain. High levels of oxidative ...
Reyes Ocampo Jazmin J Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, S.S.A., Insurgentes Sur 3877, 14269 México, DF, Mexico ; Área de Neurociencias, Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, - - 2014
The kynurenine pathway (KP) is the main route of tryptophan degradation whose final product is NAD(+). The metabolism of tryptophan can be altered in ageing and with neurodegenerative process, leading to decreased biosynthesis of nicotinamide. This fact is very relevant considering that tryptophan is the major source of body stores ...
Braidy Nady N Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, - - 2013
Over the last decade, the importance of NAD(+) has expanded beyond its role as an essential cofactor for energy metabolism. NAD(+) has emerged as a major signalling molecule that serves as the sole substrate for several enzymatic reactions including the DNA repair enzyme, poly(ADP-ribose) polymerase (PARP), NAD-dependent protein deacetylases or ...
Wierman Margaret B - - 2013
The Sirtuins are a phylogenetically conserved family of NAD(+) dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+) or biosynthesis intermediates, thus linking them to cellular metabolism. The Sir2 protein ...
Dantas L G - - 2013
Background: The prevalence of nonadherence to dialysis (NAD) presents a wide variation, depending on the parameters used and demographic regions studied. This study aimed to assess the prevalence and predictors of NAD of patients with chronic kidney disease undergoing hemodialysis (HD). Materials and Methods: This was a cross-sectional study with ...
Miyamoto K - - 2013
In vivo two-photon tomography is a novel noninvasive three-dimensional optical skin imaging technology with subcellular resolution which enables the sensitive detection of endogenous fluorophores. One of these fluorophores, NAD(P)H (a coenzyme which plays an important role in the release of free energy during glycolysis, and influences filaggrin and lipid synthesis), ...
Siegel C S CS Department of Neurology, The University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, United - - 2013
Previous literature suggests that cell death pathways activated after cerebral ischemia differ between the sexes. While caspase-dependent mechanisms predominate in the female brain, caspase-independent cell death induced by the activation of poly(ADP-ribose) polymerase (PARP) predominates in the male brain. PARP-1 gene deletion decreases infarction volume in the male brain, but ...
Wang Shaowu - - 2012
In this paper, hierarchical heteroassemblies made of interwoven Ag core nanowires (NWs) covered by ZnO branched nanorods (ZnO BNRs) are successfully prepared on a large scale via a solution bottom-up strategy coupling with a templating method. Briefly, heteroepitaxial growth of ZnO nanorods (ZnO NRs) on ZnO seed-coated Ag NWs is ...
Zhang Xin - - 2012
Au-Ag bimetallic core-shell nanoparticles are synthesized in situ in polyelectrolyte multilayers via a sequential ion-exchange/reduction process. The Au-Ag bimetallic nanoparticles show a higher catalytic activity than Au and Ag monometallic ones for the reduction of 4-nitrophenol by NaBH(4) .
An Qiao - - 2012
Highly active surface-enhanced Raman scattering (SERS) substrates of Ag nanoparticle (Ag-NP) modified Fe(3)O(4)@carbon core-shell microspheres were synthesized and characterized. The carbon coated Fe(3)O(4) microspheres were prepared via a one-pot solvothermal method and were served as the magnetic supporting substrates. The Ag-NPs were deposited by in situ reduction of AgNO(3) with ...
Chauhan Nitin - - 2012
To quantify the degree of perceived age change after aesthetic facial surgical procedures to provide an objective measure of surgical success. Sixty patients undergoing various aging face surgical procedures were randomly chosen for analysis. Preoperative and postoperative photographs were evaluated. Raters were presented with photographs in a random assortment and ...
Helmkamp James C - - 2012
We compared state-specific all-terrain vehicle (ATV) fatality rates from 2000-2007 with 1990-1999 data, grouping states according to helmet, training, and licensure requirements. We used the CDC WONDER online database to identify ATV cases from 2000-2007 and calculate rates per 100,000 population by state, gender, and age. ATV deaths (n=7,231) occurred ...
Jamal Wael - - 2012
A retrospective cohort study was performed to evaluate the outcome of modified natural IVF-intracytoplasmic sperm injection (mnIVF-ICSI) cycles to compare 81 mnIVF-ICSI first cycles using ejaculated spermatozoa with 44 mnIVF-ICSI first cycles using surgically retrieved spermatozoa. There were no differences between the two groups in terms of number of oocytes ...
Chi Yue - - 2012
In this work, we report a facile method to generate core-shell structured Fe(3)O(4)@SiO(2)-Ag magnetic nanocomposite by an in situ wet chemistry route with the aid of polyvinylpyrrolidone as both reductant and stabilizer. This method can effectively prevent Ag nanoparticles from aggregating on the silica surface, thus resulting highly dispersed and ...
Domenick Natalie - - 2012
BACKGROUND: Female sex and older age are known risk factors for adverse outcomes in peripheral artery disease. This study reports on the outcomes of tibial artery endovascular intervention (TAEI) by age and gender in patients treated for critical limb ischemia. METHODS: All TAEIs for tissue loss or rest pain (Rutherford ...
Liu Hui - - 2012
Mastery of the structure of nanomaterials enables control of their properties to enhance their performance for a given application. Herein we demonstrate the synthesis of metal nanomaterials with hollow interiors or cage-bell structures based on the inside-out diffusion of Ag in core-shell structured nanoparticles. It begins with the synthesis of ...
Potapov Evgenij - - 2012
Long-term mechanical circulatory support (MCS) with ventricular assist devices (VADs) is now an acceptable option for patients with end-stage heart failure (HF). There are growing numbers of reports identifying sex-related differences in the development and prognosis of HF and cardiac surgery. With the experience of 1,607 VAD implantations in our ...
Alvarado Rosalinda R Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2012
This study examines a modern cohort of women with ductal carcinoma-in-situ (DCIS) in order to identify potential differences in clinical presentation, treatments, and outcome based on age. From 1996 to 2009, a total of 2037 patients with pure DCIS were treated. Clinical presentation, pathologic factors, type of surgery and adjuvant ...
Stiefel M - - 2012
The purpose of this study was to analyze the participation and performance trends of male triathletes in the "Ironman Switzerland" from 1995 to 2010. Participation trends of all finishers aged between 18 and 64 years were analyzed over the 16-year period by considering four 4-year periods 1995-1998, 1999-2002, 2003-2006, and ...
Zhou Kun - - 2012
Bridging between silver clusters and polyoxoanion clusters, the first 1D assembly, [Ag(34)(S(t)Bu)(26)(W(6)O(21))(CF(3)COO)](CF(3)COO)·Et(3)N·20CH(3)OH (1), based on POM-templated silver-thiolate nanoclusters featuring a [Ag(34)(S(t)Bu)(26)(CF(3)COO)](7+) shell and a [W(6)O(21)](6-) core is reported. This novel core-shell nanocluster possesses nanoscopic morphology, displays intense deep-blue emission in solution under ambient conditions and also shows special electrochemical properties.
Llorca Javier - - 2012
PURPOSE: Mortality by tuberculosis in Spain remains greater than in other highly developed countries. The aim of this study is to identify the temporal trends in tuberculosis mortality in Spain from 1971 to 2007. METHODS: Data were obtained from the Spanish National Institute for Statistics. Age- and sex-specific mortality rates and ...
Zhao Yong-Qi - - 2012
To evaluate the shear bond strength (SBS) between alumina-toughened zirconia (ATZ) cores and veneering ceramics, investigate the effect of aging in artificial saliva on SBS and compare it with that of yttria-stabilized tetragonal zirconia polycrystals(Y-TZP). Bars of ATZ and Y-TZP were layered with veneering ceramics in accordance to the recommendation ...
Denoble Petar J - - 2012
Decompression sickness (DCS) in recreational diving is a rare and usually self-limiting injury, but permanent disability can occur. Incidence rate estimates are difficult to establish because the number of divers at risk is usually unknown in population samples with well-documented DCS. We estimated the annual per-capita DCS incidence rates for ...
Rayburn William F - - 2012
To estimate promotion rates of physician faculty members in obstetrics and gynecology during the past 30 years Data were collected annually by the Association of American Medical Colleges from every school between 1980 and 2009 for first-time assistant and associate professors to determine whether and when they were promoted. Data ...
Garritano Célia Regina - - 2012
BACKGROUND: Although it is the second leading cause of deaths worldwide, the cerebrovascular accident (CVA) has shown a significant reduction in mortality rates in recent decades. OBJECTIVE: To evaluate the trend of CVA mortality rate in Brazil, in both sexes, older than 30 years old, between 2000 and 2009. METHODS: ...
Sahu Ayaskanta - - 2012
We dope CdSe nanocrystals with Ag impurities and investigate their optical and electrical properties. Doping leads not only to dramatic changes but surprising complexity. The addition of just a few Ag atoms per nanocrystal causes a large enhancement in the fluorescence, reaching efficiencies comparable to core-shell nanocrystals. While Ag was ...
Wang Hua-Jie - - 2012
Series of mono-dispersed bovine serum albumin (BSA)-conjugated PbS/Ag(2)S core/shell nano-composites with different Pb/Ag ratios had been successfully synthesized by an ion-exchange method under the gentle conditions using BSA-conjugated PbS nano-crystals as precursors, which were prepared by a biomimetic method. Fourier transform infrared spectra analysis and transmission electron microscopy (TEM) observation ...
Kasraian Leila - - 2012
The aim of this study was to determine any relationships between return rates of first-time donors, number of donations in the first year and the donors' demographic characteristics. Data from 1,500 volunteer, first-time donors who donated blood at Shiraz Blood Transfusion Centre (Iran) were obtained from the donor database. The ...
Ide Naoko - - 2012
PURPOSE: This study analysed suicide rates among first-generation immigrants in Australia from 1974 to 2006, and compared their suicide risks against the Australian-born population. It also examined the associations between the suicide rates of immigrants from 23 selected countries of birth during 2001-2006, and in their home countries. METHOD: Age-standardised ...
Bae Seungjin - - 2012
OBJECTIVES: To estimate the rates of peptic ulcer bleeding (PUB) incidence and the association of demographic factors with 30-day mortality after PUB. METHODS: Diagnostic algorithms for PUB were derived and validated on the basis of 115 true PUB patients at one tertiary hospital in 2005, followed by estimation of age-specific ...
Pueyo María J - - 2012
OBJECTIVES: To determine whether primary drug prevention of osteoporotic hip fracture is a useful measure in Catalonia and what would be their budgetary impact. MATERIAL AND METHODS: We performed a cost-utility social perspective study with a time horizon of 10 to 20 years. Univariate sensitivity analysis was performed. Doing nothing ...
Reeve Robert - - 2012
Dot enumeration (DE) and number comparison (NC) abilities are considered markers of core number competence. Differences in DE/NC reaction time (RT) signatures are thought to distinguish between typical and atypical number development. Whether a child's DE and NC signatures change or remain stable over time, relative to other developmental signatures, ...
Zhu Ji-Ping - - 2012
Series of anode materials (Ag modified Li4TiO512) were acquired through two types of solid state calcination (doping and coating). The samples were characterized by XRD and their grain sizes were examined by laser particle-size analyzer and the morphology of them were obtained by SEM. At 0.5 C discharging rate, the ...
Tan Alai A Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555-1148, USA. - - 2012
Most studies use age as a cutoff to evaluate screening mammography utilization, generally examining screening up to age 75 years (the age-cutoff method). However, many experts and guidelines encourage clinicians to consider patient health and/or life expectancy. To compare the accuracy of estimating screening mammography utilization in older women using ...
Ata Baris - - 2012
This study retrospectively analysed array comparative genomic hybridization (CGH) results of 7753 embryos from 990 patients to determine the frequency of embryonic euploidy and its relationship with the cohort size (i.e. the number of embryos available for biopsy and array CGH analysis). Linear regression analysis was performed to assess the ...
Parsons Brian A - - 2012
PURPOSE: Voiding dysfunction becomes increasingly prevalent with ageing. Clean intermittent self-catheterisation (ISC) is associated with a lower morbidity than indwelling transurethral or suprapubic catheterisation. However, doctors and patients sometimes fail to consider ISC as an option because of a perception it will be unmanageable or poorly tolerated. This study aimed ...
Munné Santiago - - 2012
OBJECTIVE: To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. DESIGN: Retrospective study. SETTING: Fertility centers. PATIENT(S): Infertile couples undergoing IVF. INTERVENTION(S): Patients underwent two consecutive cycles ...
Bayon Germain - - 2012
About 3000 years ago, a major vegetation change occurred in Central Africa, when rainforest trees were abruptly replaced by savannas. The consensus is that the forest disturbance was caused by climate change. We show here that chemical weathering in Central Africa, reconstructed from geochemical analyses of a marine sediment core, ...
Kelehear Crystal - - 2012
Ecology Letters (2012) ABSTRACT: Parasites of invading species undergoing range advance may be exposed to powerful new selective forces. Low host density in range-edge populations hampers parasite transmission, requiring the parasite to survive longer periods in the external environment before encountering a potential host. These conditions should favour evolutionary shifts ...
Su An-Kuo - - 2012
The goal of this research, conducted in the most southern part of Taiwan, was to create a new genotype: the "Hengchun Black Goat" (HB). Nubian (NU) goats were first crossed with a local breed, the Taiwan native (TN), then the F1 females were crossed with the imported black Boer (BO) ...
Shen Yu-Lin - - 2012
Without using any templates or surfactants, this study develops a high-yield process to prepare vertical Ag-Pt core-shell nanowires (NWs) by thermally assisted photoreduction of Ag NWs and successive galvanic replacement between Ag and Pt ions. The clean surface of Ag nanowires allows Pt ions to reduce and deposit on it ...
Uthicke S - - 2012
Coral reefs are under pressure from a variety of human-induced disturbances, but demonstration of ecosystem changes and identification of stressors are often difficult. We tested whether global change or increased agricultural runoff after European settlement of Northeast Australia (ca. 1860) has affected inshore reefs of the Great Barrier Reef. Eleven ...
Bastiaannet Esther - - 2012
Background. The incidence of ductal carcinoma in situ (DCIS) has increased at a fast rate.The aim of this study was to assess the incidence and treatment in the Netherlands and estimate the excess mortality risk of DCIS. Methods. From the Netherlands Cancer Registry, adult female patients (diagnosed 1997-2005) with DCIS ...
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