Search Results
Results 1 - 50 of 1625
1 2 3 4 5 6 7 8 9 10 >
Flechtner-Mors Marion - - 2014
Objective of the present study was to examine the association between adiponectin and hepatic steatosis, and other biochemical and anthropometric parameters in healthy subjects. A total of 1349 subjects (age 18-65 years) underwent ultrasound examination of the liver. Mean adiponectin concentration for the study collective was 11.35 +/- 6.28 mug/mL. ...
Tritos Nicholas A NA Neuroendocrine Unit (N.A.T., K.K.M., A.K., B.M.K.B.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Department of Endocrinology (G.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Endocrinology (M.K.), Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom; Department of Medical Endocrinology (U.F.-R.), Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark; Division of Endocrinology, Diabetes, and Clinical Nutrition (K.C.J.Y.), Oregon Health and Science University, Portland, Oregon; Pfizer, Inc (D.K.), New York, New York; and Pfizer Endocrine Care (P.J.J., M.K.-H.), Sollentuna, - - 2014
Context: GH deficiency (GHD) may occur in adults with cured acromegaly (acroGHD). Objective: Our objective was to examine the effectiveness and safety of GH replacement in acroGHD. Design: This study was a retrospective analysis of data from KIMS (Pfizer International Metabolic Database). Setting: We conducted a pharmaco-epidemiological survey of >16 ...
Yin Z-G ZG Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, - - 2014
Metabolic syndrome (MetS) has been reported to be associated with silent lacunar infarction, which is highly related to white matter lesions (WMLs). However, little is known about the relationship between MetS and the prevalence of WMLs. The association between MetS, its components and WMLs in middle-aged and elderly patients was ...
Wang Hongyu H Department of Vascular Medicine, Peking University Shougang Hospital , Beijing , P.R. China - - 2014
Abstract Objectives: Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. However, there was little research about the CAVI value between different countries. The aim of the present study was to compare CAVI between Chinese and Japanese subjects and ...
Wang Han-Mei HM Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, No. 148, Baojian Road, Nangang District, Harbin, 150086, - - 2014
To study the association between known risk factors for cardiovascular disease and intima-media thickness (IMT) in the carotid and popliteal arteries in middle-aged and elderly Chinese adults. 686 middle aged and elderly Chinese adults from the China Da Qing Diabetes Prevention Study who had full clinical, laboratory, ultrasound examination results ...
Clarke-Harris Rebecca R Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, - - 2014
The early environment, acting via epigenetic processes, is associated with differential risk of cardio-metabolic disease (CMD) which can be predicted by epigenetic marks in proxy tissues. However, such measurements at time points disparate from the health outcome or the environmental exposure may be confounded by intervening stochastic and environmental variation. ...
Kawasumi Koh - - 2014
In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the ...
Pinto Camila S CS Endocrinology Division, Diabetes Center, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, - - 2014
The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 ± 4.0 years, disease duration 9.8 ± 4.8 years) and for ...
Vigna G B GB Medical Department, Azienda Ospedaliera-Universitaria di Ferrara, Ferrara, Italy. Electronic address: - - 2014
The relationships between very high plasma HDLc and subclinical atherosclerosis are still a matter of debate. Twenty subjects with primary hyperalphalipoproteinemia (HAL, with HDLc in the highest 10th percentile and absence of overt secondary causes of this condition), aged 30-65 years, were compared with 20 age and sex-matched controls. Lipid ...
Nam Ga Eun GE Department of Family Medicine, Korea University College of Medicine, Seoul, South - - 2014
This study aimed to investigate recent trends in the prevalence and parameters of dyslipidemia and rates of lipid-lowering medication use in Korean adults. Trends in lipid profiles in subjects with hypertension, diabetes or obesity were also studied. Data from the Korea National Health and Nutrition Examination Survey in 2005, 2008 ...
Kappelgaard Anne-Marie AM Medical Affairs, Global Marketing GHT, Novo Nordisk A/S, Søborg, - - 2014
Background/Aims: An examination of the effects of up to 260 weeks of growth hormone (GH) therapy on metabolic parameters in Japanese children born small for gestational age (SGA). Methods: Data were analysed from a 156-week extension of a 104-week multicentre, randomised, double-blind, parallel-group trial. Sixty-five children born SGA (age 3-<8 ...
Speeckaert Marijn M MM Department of Nephrology, Ghent University Hospital, Gent, Belgium. Electronic address: - - 2014
As ageing is a complex phenomenon characterized by intraindividual and interindividual diversities in the maintenance of the homeostatic condition of cells and tissues, changes in renal function are not uniform and depend on associated diseases and environmental factors. Multiple studies have investigated the possible underlying mechanisms of age-related decline in ...
Taniguchi Yu Y Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. - - 2014
Micronutrients are associated with dementia and cognitive decline among older adults. However, nutritional biomarkers of such decline have not been identified. We attempted to identify nutritional biomarkers that were independent risk markers of cognitive decline in a population of older Japanese. Among 873 cognitively intact adults aged 70 years or ...
Wang Zaimin Z Centre for Chronic Disease, School of Medicine, The University of - - 2014
Objective: To determine trends in health status over a 10-year interval in a high-risk remote Australian Aboriginal community. Methods: Two health surveys were performed, one between 1992 and 1997 and the other between 2004 and 2006, on people aged five years or older. Outcomes were compared across age-matched and sex-matched ...
Scuteri Angelo A San Raffaele Pisana (HSR) IRCCS, Rome, Italy. Electronic address: - - 2014
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim ...
Ando Ayumi A Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Yahaba, - - 2014
The objective of this study was to determine the associations of number of teeth with all-cause mortality and cause-specific mortality among middle-aged and elderly Japanese men. A total of 7779 men aged 40-79 years who were free from cardiovascular disease (CVD) were followed up prospectively for 5.6 years. Participants were categorized into ...
Boyne Michael S - - 2014
Abstract An earlier onset of puberty is associated with increased cardiometabolic risk. We investigated whether this relation was independent of faster childhood growth or current size in an Afro-Caribbean birth cohort (n=259). Anthropometry was measured at birth and then 6-monthly. Tanner staging started at age 8 years. Cardiometabolic risk factors ...
Hulmán Adam A Department of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, - - 2014
Secular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort. Development of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 308 participants aged from 35 to ...
Li Chung-Hao CH Department of Family Medicine, Tainan Municipal An-Nan Hospital- China Medical University, - - 2014
Tea has attracted considerable attention for its potential cardioprotective effects. The primary chemical components of tea are thought to have a beneficial effect by reducing arterial stiffness. The objective of this study was to assess the association between tea consumption and brachial-ankle pulse wave velocity (baPWV) in a relatively healthy ...
Aslan Raziye R Department of Family Medicine, Meram Medical Faculty, University of Konya, Turkey. Electronic address: - - 2014
In this study, we aimed to assess the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) in smokers and nonsmokers. This cross-sectional analytical study was conducted on 100 smokers and 100 nonsmokers. Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), triglyceride (TG), fasting ...
Mulero J J Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia, - - 2014
Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment and blindness among persons aged 60 years and older and many theories exist and feature mechanisms of oxidative stress, atherosclerotic-like changes, genetic predisposition, and inflammation in development of AMD. The aim of this study was to evaluate the ...
Sato Kimiko K Prefectural University of - - 2014
Objectives: We examined the factors considered to change body composition and blood biochemistry indicators in menopausal middle-aged and elderly women. These changes result from exercise by walking as part of their daily activities and lemon consumption by women who live on the small islands of the Seto Inland Sea, Japan's ...
Marianecci Carlotta C Department of Drug Chemistry and Technologies, University Sapienza of Rome, Rome, - - 2014
Liquorice extracts demonstrate therapeutic efficacy in treating dermatitis, eczema, and psoriasis when compared with corticosteroids. In this work, nonionic surfactant vesicles (niosomes, NSVs) containing polysorbate 20 (Tween 20), cholesterol, and cholesteryl hemisuccinate at different molar concentrations were used to prepare monoammonium glycyrrhizinate (AG)-loaded NSVs. The anti-inflammatory properties of AG-loaded NSVs ...
Kaess Bernhard M BM Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom ; Deutsches Herzzentrum, Technische Universität, Munich, Germany ; Department for Internal Medicine II, University Hospital Regensburg, Regensburg, - - 2014
The impact of fast changes in obesity indices on other measures of metabolic health is poorly defined in the general population. Using the Polish accession to the European Union as a model of political and social transformation we examined how an expected rapid increase in body mass index (BMI) and ...
He Chih-Tsueng CT 0000-0002-1918-5186 Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, Taipei 10581, Taiwan ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, - - 2014
The aim of this cross-sectional study was to investigate the relationship between soluble form of receptor for advanced glycation end products (sRAGE), obesity, and metabolic syndrome (MetS) in adolescents. A total of 522 male and 561 female adolescents were enrolled into the final analyses. Anthropometric parameters, blood pressure, blood biochemistry, ...
Zamuner Marina M Faculty of Medicine, Pontifical Catholic University of Campinas (PUC-Campinas), 13060-904 Campinas, SP, - - 2014
To define whether the association of male lower urinary tract symptoms (LUTS) and metabolic syndrome (MS) is real or simply an epiphenomenon, 490 male adults (mean age 58 ± 9 years) underwent International Prostate Symptom Score (IPSS), physical and prostate digital examinations, blood analysis, and urinary tract transabdominal ultrasound with ...
Kim J J Division of Biological Sciences, University of California, 9500 Gilman Drive, La Jolla, CA, - - 2014
p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss of sebaceous gland (SG). The reduction ...
Bertolotti Marco M Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, - - 2014
The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. We analyzed serum samples collected from 201 adult (75 male, 126 female) subjects within the epidemiological MICOL study ...
Salinas Jennifer J JJ University of Texas Health Science Center, School of Public Health, Brownsville Campus, 80 Fort Brown, Brownsville, TX 78520. E-mail: - - 2014
Although the relationship between health behaviors and outcomes such as smoking and obesity with longer residence in the United States among Mexican American immigrants is established, the relationship between length of residency in the United States and risk for cardiovascular disease (CVD) is not fully understood. The objective of this ...
Koyama Satomi S Departments of Pediatrics, - - 2013
OBJECTIVE:The age of adiposity rebound (AR) is defined as the time at which BMI starts to rise after infancy and is thought to be a marker of later obesity. To determine whether this age is related to future occurrence of metabolic syndrome, we investigated the relationship of the timing of ...
Milman Sofiya - - 2013
A change in the lipoprotein profile is a metabolic hallmark of aging and has been the target for modern medical developments. Although pharmaceutical interventions aimed at lipid lowering substantially decrease the risk of cardiovascular disease, they have much less impact on mortality and longevity. Moreover, they have not affected death ...
Miedema Michael D MD Brigham and Women's Hospital, Division of Aging, and Boston Veteran Affairs Healthcare System, Harvard Medical School, Boston, - - 2014
Adult height has been hypothesized to be inversely associated with coronary heart disease; however, studies have produced conflicting results. We sought to examine the relationship between adult height and the prevalence of coronary artery calcium (CAC), a direct measure of subclinical atherosclerosis and surrogate marker of coronary heart disease. We ...
Mikkelsen U R - - 2013
Human aging is associated with a loss of skeletal muscle and an increase in circulating inflammatory markers. It is unknown whether endurance training (Tr) can prevent these changes. Therefore we studied 15 old trained (O-Tr) healthy males and, for comparison, 12 old untrained (O-Un), 10 Young-Tr (Y-Tr) and 12 Young-Un ...
Pan Jian Gang - - 2013
Objectives: To evaluate the relationship between metabolic syndrome (MetS) and annual prostate growth rates in Chinese patients of different age decades with benign prostatic hyperplasia (BPH). Methods: We retrospectively analyzed the clinical data obtained from 1,052 Chinese men with BPH. Overnight fasting venous blood specimens were collected and serum levels ...
Wendell Carrington R - - 2013
Objective: Prior literature has identified inconsistent longitudinal associations between total cholesterol and cognitive decline. The authors examined prospective nonlinear relations of coincident trajectories of total cholesterol and cognitive function among persons free of stroke, dementia, and other neurological disease. Method: Up to 1,601 participants from the Baltimore Longitudinal Study of ...
Keefer Daniel J - - 2013
The purpose of this investigation was to determine if waist-to-height ratio (WHTR) or body mass index (BMI) is the better indicator of cardiovascular disease risk in children and adolescents of varying ages. Data from children and adolescents (N = 2300) who were part of the 2003-2004 National Health and Nutrition Examination Survey ...
Mutombo Paulin Beya Wa Bitadi - - 2013
Abstract Background: Type 2 diabetes (T2D) is among the leading public health problems in Japan, and glycated hemoglobin (HbA1c) can be used to screen the population for T2D. Gene polymorphisms, known to be associated with obesity, may predispose individuals to T2D. Rs17782313 the melanocortin 4 receptor (MC4R) has shown one ...
Eberhard Jörg - - 2013
To investigate the association between periodontal disease severity and cardiorespiratory fitness (CRF) in a cross-sectional study of sedentary men. Seventy-two healthy men (45 to 65 years) who did not join any sport activity and had a preferentially sitting working position were recruited. Periodontal status was recorded and CRF was measured ...
Dai Shifan - - 2013
To estimate age-related changes for serum concentration of non-high-density lipoprotein cholesterol (HDL-C), describe non-HDL-C distribution, and examine the prevalence of high non-HDL-C levels in children and adolescents by demographic characteristics and weight status. Data from 7058 participants ages 6-19 years in the 2005-2010 National Health and Nutrition Examination Surveys were ...
Koutseff Alexis - - 2013
Apolipoprotein E (ApoE) is found in three different forms in humans (ApoE2, ApoE3 and ApoE4), and ApoE polymorphism is recognized as a major risk factor for Alzheimer's disease (AD). ApoE is involved in lipid and cholesterol transport, cell repair, and amyloid-β deposition and certain studies suggest potential implications in neurogenesis. ...
Fahed Akl C - - 2013
Intima-media thickness (IMT) is a well-described marker of cardiovascular disease. In this study we aim to determine whether low-density lipoprotein (LDL) levels and disease-related mutation status can predict IMT in patients with severe familial hypercholesterolemia (FH) referred for or on LDL apheresis. Genetic screening, lipid profile testing, and IMT measurements ...
Usui Shiho - - 2013
The objectives of this study were to set specific dog breed and sex standards for total cholesterol (T-Cho) and total triglyceride (T-TG) concentrations in dogs and to quantify the associations between dog age and concentrations of both lipids for different breeds. Increased age was associated with higher T-Cho and T-TG ...
Dumurgier Julien - - 2013
Vascular risk factors contribute to motor decline in the elderly persons. We investigated the relationship between lipid-lowering drugs (LLDs) use and decline in walking speed (WS) in older adults. Data on 4,009 community-dwelling men and women, aged ≥65 years at baseline, are drawn from the Dijon (France) center of the ...
Vashum Khanrin P - - 2013
The aim of this research is to estimate the prevalence of excessive daytime sleepiness in an older population and associations with sociodemographic, health, and lifestyle factors using a cross-sectional, population-based study. Participants were men (1560) and women (1759), aged 55 to 85 years, enrolled in the Hunter Community Study, a ...
Jacobs Jeremy M - - 2013
The importance of cholesterol as a risk factor among older people, particularly among the very old, is controversial. Whether or not hypercholesterolemia warrants medical concern, and whether statins are beneficial among very old people, remain unresolved common clinical dilemmas. This study examines whether increased total cholesterol (TC) was associated with ...
Roy A - - 2013
Background: Coronary Heart Disease (CHD) is the leading cause of death in many developed countries. The relation between heart rate variability (HRV) and CHD was recently explored after the development of HRV techniques. Lower HRV was proven to be associated with a greater risk for developing hypertension among normotensive men, ...
Suwatanaviroj Tan T Nopparat Rajathanee Hospital, Bangkok, Thailand. - - 2013
To compare the prevalence of coronary artery disease (CAD) between Thai Muslim and Thai Buddhist patients. A hospital based retrospective study was carried out to investigate the prevalence of CAD and cardiovascular risk factors of these two ethnic and religious groups at Nopparat Rajathanee Hospital between June 2012 and December ...
Smiljanic Kosara - - 2013
Disturbance of cholesterol homeostasis in the brain is coupled to age-related brain dysfunction. In the present work, we studied the relationship between aging and cholesterol metabolism in two brain regions, the cortex and hippocampus, as well as in the sera and liver of 6-, 12-, 18- and 24-month-old male Wistar ...
Xu Yan-Ping - - 2013
To confirm the hypothesis that polymorphisms of the uncoupling protein 3 (UCP3) gene are associated with the occurrence of nonalcoholic fatty liver disease (NAFLD). A total of 250 NAFLD patients (147 males and 103 females) and 200 healthy individuals who served as controls (control, 109 males and 91 females), aged ...
Seidlerová Jitka - - 2013
Aortic stiffness is strongly related to age and mean arterial pressure (MAP). In the present analysis, we investigated whether antihypertensive treatment modulates the association of the aortic pulse wave velocity (PWV) with age and with MAP in the general population. In the Czech post-MONICA cross-sectional study, we measured the PWV ...
1 2 3 4 5 6 7 8 9 10 >