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Corley Janie J Department of Psychology,University of Edinburgh,7 George Square,Edinburgh EH8 - - 2014
ABSTRACT Background: We examined the associations between serum cholesterol measures, statin use, and cognitive function measured in childhood and in old age. The possibility that lifelong (trait) cognitive ability accounts for any cross-sectional associations between cholesterol and cognitive performance in older age, seen in observational studies, has not been tested ...
Redondo Olga O 1Social and Cardiovascular Epidemiology Research Group,School of Medicine,University of Alcalá,Alcalá de Henares,Madrid - - 2014
To identify a body fat percentage (%BF) threshold related to an adverse cardiometabolic profile and its surrogate BMI cut-off point. Cross-sectional study. Two public schools in poor urban areas on the outskirts of Guatemala City. A convenience sample of ninety-three healthy, prepubertal, Ladino children (aged 7-12 years). Spearman correlations of ...
Cavallini Gabriella G Interdepartmental Research Centre on Biology and Pathology of Aging Via Roma 55, I-56126 Pisa, Italy. - - 2014
Aging has been defined as a gradually decreasing ability to maintain homeostasis and increasing risk to die. Growing evidence supports malfunctioning with age of quality control system. At an older age, accumulation of altered macromolecules and membranes may impair cell functioning; accumulation of altered mitochondria and peroxisomes may boost the ...
Freitas Wladimir M WM Department of Cardiology, Faculty of Medical Sciences, State University of Campinas Medical School (UNICAMP), Campinas, Sao Paulo, 13084-971, - - 2014
Although low-density lipoprotein cholesterol (LDL-C) has been consistently demonstrated a predictor of atherosclerotic disease in a large spectrum of clinical settings, among individuals aged of 80 years or older this concept is uncertain. This study was evaluated in a carefully selected population if the association between LDL-C and coronary atherosclerotic burden ...
Belcher Britni Ryan BR Cancer Prevention Fellowship Program, Division of Cancer Prevention, Risk Factor Monitoring and Methods Branch, Applied Research Program, National Cancer Institute, Bethesda, - - 2014
Discrepancies in self-report and accelerometer-measured moderate-to-vigorous physical activity (MVPA) may influence relationships with obesity-related biomarkers in youth. Data came from 2003-2006 National Health and Nutrition Examination Surveys (NHANES) for 2174 youth ages 12-19. Biomarkers were: body mass index (BMI, kg/m2), BMI percentile, height and waist circumference (WC, cm), triceps and ...
Keith Dove D Linus Pauling Institute, Oregon State University, United - - 2014
It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis in aged animals, ...
Dowd Jennifer B JB Department of Epidemiology and Biostatistics, City University of New York School of Public Health, Hunter College, City University of New York Institute for Demographic Research, City University of New York, New York, New York. Electronic address: - - 2014
People worldwide are becoming obese at earlier ages, increasing exposure to long-term obesity. To examine how BMI at age 25 years predicts later obesity and test the importance of long-term obesity beyond obesity severity for adult cardiovascular, inflammatory, and metabolic risk. Data from adults aged 35-64 years from the 1999-2010 ...
Baughman Penelope P National Institute for Occupational Safety and Health, Morgantown, WV, - - 2014
Policing is considered a high-stress occupation and officers have elevated cardiovascular morbidity and mortality. We evaluated the association between salivary cortisol response to a standardised challenge and the metabolic syndrome (MetSyn), an indicator of increased cardiovascular risk. Cross-sectional data from the Buffalo Cardio-Metabolic Occupational Police Stress Study (2004-2009) were analysed. ...
Martin Mauricio G MG Centro Biología Molecular "Severo Ochoa" CSIC-UAM, Madrid, Spain VIB Center for the Biology of Disease, Center for Human Genetics, University of Leuven (KU Leuven), Leuven, Belgium mauricio.m@immf.uncor.edu - - 2014
Cognitive decline is one of the many characteristics of aging. Reduced long-term potentiation (LTP) and long-term depression (LTD) are thought to be responsible for this decline, although the precise mechanisms underlying LTP and LTD dampening in the old remain unclear. We previously showed that aging is accompanied by the loss ...
Hanssen Nordin M J NM CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht, the - - 2014
Experimental data suggest a role for advanced glycation endproducts (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, epidemiological evidence of an association between high plasma AGEs and increased cardiovascular risk remains inconclusive. Therefore, in a case-cohort study comprising 134 cardiovascular cases and a random subcohort of ...
Grosman Halina H Clinical Biochemistry Department, Facultad de Farmacia y Bioquímica, INFIBIOC, Universidad de Buenos Aires , Buenos Aires , Argentina - - 2014
Abstract Objective: To evaluate the relationship between testosterone levels and the metabolic syndrome (MS) in men older than 45 years. Methods: Six hundred and sixty men (45-70 years) selected from 2906 participants of a population screening for prostate cancer were included in this study. Testosterone and the components of MS ...
Hawley Nicola L NL Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, Rhode Island; The Alpert Medical School, Brown University, Providence, Rhode - - 2014
To describe the prevalence of obesity-related noncommunicable diseases (NCDs) and associated risk factors in a sample of Samoan adults studied in 2010 as part of a genome-wide assocation study (GWAS) for obesity related traits. Anthropometric and biochemical data collected from n = 3,475 participants (n = 1,437 male; n = ...
Li Wen-Cheng WC Department of Occupation Medicine, Keelung Chang-Gung Memorial Hospital, No. 222, Maijin Rd., Keelung, - - 2014
Obesity, metabolic syndrome (MS), and chronic kidney disease (CKD) are all becoming increasingly prevalent worldwide. Body mass index (BMI) has traditionally been employed to identify overweight or obese individuals, yet multiple studies have yielded conflicting results when BMI was used to evaluate the association between obesity and CKD. The purpose ...
Simino Jeannette J Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 South Euclid Avenue, Campus Box 8067, Saint Louis, MO 63110-1093, USA. Electronic address: - - 2014
To detect novel loci with age-dependent effects on fasting (≥8 h) levels of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides using 3600 African Americans, 1283 Asians, 3218 European Americans, and 2026 Mexican Americans from the Family Blood Pressure Program (FBPP). Within each subgroup (defined by network, race, and sex), we ...
Robinson Jennifer J Professor, Departments of Epidemiology & Medicine, University of Iowa. Electronic address: - - 2014
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in developed and developing countries. Despite decades of effort, unhealthy lifestyle habits and ASCVD risk factor levels remain high, and are increasing in many population groups. A new approach to ASCVD prevention is needed. Multiple lines of evidence from animal ...
Flechtner-Mors Marion - - 2014
Objective of the present study was to examine the association between adiponectin and hepatic steatosis, and other biochemical and anthropometric parameters in healthy subjects. A total of 1349 subjects (age 18-65 years) underwent ultrasound examination of the liver. Mean adiponectin concentration for the study collective was 11.35 +/- 6.28 mug/mL. ...
Tritos Nicholas A NA Neuroendocrine Unit (N.A.T., K.K.M., A.K., B.M.K.B.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; Department of Endocrinology (G.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Endocrinology (M.K.), Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom; Department of Medical Endocrinology (U.F.-R.), Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark; Division of Endocrinology, Diabetes, and Clinical Nutrition (K.C.J.Y.), Oregon Health and Science University, Portland, Oregon; Pfizer, Inc (D.K.), New York, New York; and Pfizer Endocrine Care (P.J.J., M.K.-H.), Sollentuna, - - 2014
Context: GH deficiency (GHD) may occur in adults with cured acromegaly (acroGHD). Objective: Our objective was to examine the effectiveness and safety of GH replacement in acroGHD. Design: This study was a retrospective analysis of data from KIMS (Pfizer International Metabolic Database). Setting: We conducted a pharmaco-epidemiological survey of >16 ...
Yin Z-G ZG Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, - - 2014
Metabolic syndrome (MetS) has been reported to be associated with silent lacunar infarction, which is highly related to white matter lesions (WMLs). However, little is known about the relationship between MetS and the prevalence of WMLs. The association between MetS, its components and WMLs in middle-aged and elderly patients was ...
Wang Hongyu H Department of Vascular Medicine, Peking University Shougang Hospital , Beijing , P.R. China - - 2014
Abstract Objectives: Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. However, there was little research about the CAVI value between different countries. The aim of the present study was to compare CAVI between Chinese and Japanese subjects and ...
Wang Han-Mei HM Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, No. 148, Baojian Road, Nangang District, Harbin, 150086, - - 2014
To study the association between known risk factors for cardiovascular disease and intima-media thickness (IMT) in the carotid and popliteal arteries in middle-aged and elderly Chinese adults. 686 middle aged and elderly Chinese adults from the China Da Qing Diabetes Prevention Study who had full clinical, laboratory, ultrasound examination results ...
Clarke-Harris Rebecca R Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, - - 2014
The early environment, acting via epigenetic processes, is associated with differential risk of cardio-metabolic disease (CMD) which can be predicted by epigenetic marks in proxy tissues. However, such measurements at time points disparate from the health outcome or the environmental exposure may be confounded by intervening stochastic and environmental variation. ...
Kawasumi Koh - - 2014
In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the ...
Pinto Camila S CS Endocrinology Division, Diabetes Center, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, - - 2014
The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 ± 4.0 years, disease duration 9.8 ± 4.8 years) and for ...
Vigna G B GB Medical Department, Azienda Ospedaliera-Universitaria di Ferrara, Ferrara, Italy. Electronic address: - - 2014
The relationships between very high plasma HDLc and subclinical atherosclerosis are still a matter of debate. Twenty subjects with primary hyperalphalipoproteinemia (HAL, with HDLc in the highest 10th percentile and absence of overt secondary causes of this condition), aged 30-65 years, were compared with 20 age and sex-matched controls. Lipid ...
Petrásová Darina - - 2014
Obesity and overweight are major contributors to the global burden of chronic diseases and disability in both majority and minority populations. Data from the cross-sectional population-based HepaMeta study conducted in Slovakia in 2011 were used. The sample comprised a total of 452 Roma. Measurements of special bioactive mediators were taken ...
Nam Ga Eun GE Department of Family Medicine, Korea University College of Medicine, Seoul, South - - 2014
This study aimed to investigate recent trends in the prevalence and parameters of dyslipidemia and rates of lipid-lowering medication use in Korean adults. Trends in lipid profiles in subjects with hypertension, diabetes or obesity were also studied. Data from the Korea National Health and Nutrition Examination Survey in 2005, 2008 ...
Kappelgaard Anne-Marie AM Medical Affairs, Global Marketing GHT, Novo Nordisk A/S, Søborg, - - 2014
Background/Aims: An examination of the effects of up to 260 weeks of growth hormone (GH) therapy on metabolic parameters in Japanese children born small for gestational age (SGA). Methods: Data were analysed from a 156-week extension of a 104-week multicentre, randomised, double-blind, parallel-group trial. Sixty-five children born SGA (age 3-<8 ...
Speeckaert Marijn M MM Department of Nephrology, Ghent University Hospital, Gent, Belgium. Electronic address: - - 2014
As ageing is a complex phenomenon characterized by intraindividual and interindividual diversities in the maintenance of the homeostatic condition of cells and tissues, changes in renal function are not uniform and depend on associated diseases and environmental factors. Multiple studies have investigated the possible underlying mechanisms of age-related decline in ...
Taniguchi Yu Y Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. - - 2014
Micronutrients are associated with dementia and cognitive decline among older adults. However, nutritional biomarkers of such decline have not been identified. We attempted to identify nutritional biomarkers that were independent risk markers of cognitive decline in a population of older Japanese. Among 873 cognitively intact adults aged 70 years or ...
Wang Zaimin Z Centre for Chronic Disease, School of Medicine, The University of - - 2014
Objective: To determine trends in health status over a 10-year interval in a high-risk remote Australian Aboriginal community. Methods: Two health surveys were performed, one between 1992 and 1997 and the other between 2004 and 2006, on people aged five years or older. Outcomes were compared across age-matched and sex-matched ...
Scuteri Angelo A San Raffaele Pisana (HSR) IRCCS, Rome, Italy. Electronic address: - - 2014
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim ...
Ando Ayumi A Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Yahaba, - - 2014
The objective of this study was to determine the associations of number of teeth with all-cause mortality and cause-specific mortality among middle-aged and elderly Japanese men. A total of 7779 men aged 40-79 years who were free from cardiovascular disease (CVD) were followed up prospectively for 5.6 years. Participants were categorized into ...
Boyne Michael S - - 2014
Abstract An earlier onset of puberty is associated with increased cardiometabolic risk. We investigated whether this relation was independent of faster childhood growth or current size in an Afro-Caribbean birth cohort (n=259). Anthropometry was measured at birth and then 6-monthly. Tanner staging started at age 8 years. Cardiometabolic risk factors ...
Hulmán Adam A Department of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, - - 2014
Secular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort. Development of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 308 participants aged from 35 to ...
Li Chung-Hao CH Department of Family Medicine, Tainan Municipal An-Nan Hospital- China Medical University, - - 2014
Tea has attracted considerable attention for its potential cardioprotective effects. The primary chemical components of tea are thought to have a beneficial effect by reducing arterial stiffness. The objective of this study was to assess the association between tea consumption and brachial-ankle pulse wave velocity (baPWV) in a relatively healthy ...
Aslan Raziye R Department of Family Medicine, Meram Medical Faculty, University of Konya, Turkey. Electronic address: - - 2014
In this study, we aimed to assess the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) in smokers and nonsmokers. This cross-sectional analytical study was conducted on 100 smokers and 100 nonsmokers. Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), triglyceride (TG), fasting ...
Mulero J J Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia, - - 2014
Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment and blindness among persons aged 60 years and older and many theories exist and feature mechanisms of oxidative stress, atherosclerotic-like changes, genetic predisposition, and inflammation in development of AMD. The aim of this study was to evaluate the ...
Sato Kimiko K Prefectural University of - - 2014
Objectives: We examined the factors considered to change body composition and blood biochemistry indicators in menopausal middle-aged and elderly women. These changes result from exercise by walking as part of their daily activities and lemon consumption by women who live on the small islands of the Seto Inland Sea, Japan's ...
Marianecci Carlotta C Department of Drug Chemistry and Technologies, University Sapienza of Rome, Rome, - - 2014
Liquorice extracts demonstrate therapeutic efficacy in treating dermatitis, eczema, and psoriasis when compared with corticosteroids. In this work, nonionic surfactant vesicles (niosomes, NSVs) containing polysorbate 20 (Tween 20), cholesterol, and cholesteryl hemisuccinate at different molar concentrations were used to prepare monoammonium glycyrrhizinate (AG)-loaded NSVs. The anti-inflammatory properties of AG-loaded NSVs ...
Kaess Bernhard M BM Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom ; Deutsches Herzzentrum, Technische Universität, Munich, Germany ; Department for Internal Medicine II, University Hospital Regensburg, Regensburg, - - 2014
The impact of fast changes in obesity indices on other measures of metabolic health is poorly defined in the general population. Using the Polish accession to the European Union as a model of political and social transformation we examined how an expected rapid increase in body mass index (BMI) and ...
He Chih-Tsueng CT 0000-0002-1918-5186 Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, Taipei 10581, Taiwan ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, - - 2014
The aim of this cross-sectional study was to investigate the relationship between soluble form of receptor for advanced glycation end products (sRAGE), obesity, and metabolic syndrome (MetS) in adolescents. A total of 522 male and 561 female adolescents were enrolled into the final analyses. Anthropometric parameters, blood pressure, blood biochemistry, ...
Zamuner Marina M Faculty of Medicine, Pontifical Catholic University of Campinas (PUC-Campinas), 13060-904 Campinas, SP, - - 2014
To define whether the association of male lower urinary tract symptoms (LUTS) and metabolic syndrome (MS) is real or simply an epiphenomenon, 490 male adults (mean age 58 ± 9 years) underwent International Prostate Symptom Score (IPSS), physical and prostate digital examinations, blood analysis, and urinary tract transabdominal ultrasound with ...
Kim J J Division of Biological Sciences, University of California, 9500 Gilman Drive, La Jolla, CA, - - 2014
p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss of sebaceous gland (SG). The reduction ...
Bertolotti Marco M Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, - - 2014
The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. We analyzed serum samples collected from 201 adult (75 male, 126 female) subjects within the epidemiological MICOL study ...
Salinas Jennifer J JJ University of Texas Health Science Center, School of Public Health, Brownsville Campus, 80 Fort Brown, Brownsville, TX 78520. E-mail: - - 2014
Although the relationship between health behaviors and outcomes such as smoking and obesity with longer residence in the United States among Mexican American immigrants is established, the relationship between length of residency in the United States and risk for cardiovascular disease (CVD) is not fully understood. The objective of this ...
Yin Ze-Gang ZG Department of Neurology, Daping Hospital and Institute of Field Surgery, Third Military Medical University, Chongqing, - - 2014
Apolipoprotein A-I (apoA-I), the major protein for high density lipoprotein, is essential for reverse cholesterol transport. Decreased serum levels of apoA-I have been reported to correlate with subcortical infarction and dementia, both of which are highly related to white matter lesions (WMLs). However, the association between apoA-I and WMLs has ...
Shin Jeong Ah JA Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of - - 2014
We investigated whether thyroid function could identify obesity phenotype in euthyroid subjects. A cross-sectional analysis was performed among nondiabetic, euthyroid subjects. We stratified subjects into four groups by BMI and insulin resistance (IR). Of 6241 subjects, 33.8% were overweight or obese (OW/OB) and 66.2% were normal weight (NW). Free thyroxine ...
Koyama Satomi S Departments of Pediatrics, - - 2013
OBJECTIVE:The age of adiposity rebound (AR) is defined as the time at which BMI starts to rise after infancy and is thought to be a marker of later obesity. To determine whether this age is related to future occurrence of metabolic syndrome, we investigated the relationship of the timing of ...
Milman Sofiya - - 2013
A change in the lipoprotein profile is a metabolic hallmark of aging and has been the target for modern medical developments. Although pharmaceutical interventions aimed at lipid lowering substantially decrease the risk of cardiovascular disease, they have much less impact on mortality and longevity. Moreover, they have not affected death ...
Miedema Michael D MD Brigham and Women's Hospital, Division of Aging, and Boston Veteran Affairs Healthcare System, Harvard Medical School, Boston, - - 2014
Adult height has been hypothesized to be inversely associated with coronary heart disease; however, studies have produced conflicting results. We sought to examine the relationship between adult height and the prevalence of coronary artery calcium (CAC), a direct measure of subclinical atherosclerosis and surrogate marker of coronary heart disease. We ...
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