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Results 351 - 400 of 2093
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Aniket Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, - - 2014
Pro-osteogenic stimulation of bone cells by bioactive ceramic-coated orthopedic implants is influenced by both surface roughness and material chemistry; however, their concomitant impact on osteoblast behavior is not well understood. The aim of this study is to investigate the effects of nano-scale roughness and chemistry of bioactive silica-calcium phosphate nanocomposite ...
Chen Chih-Lung CL Graduate Institute of Life Science, National Defense Medical Center, Taipei 114, Taiwan; Genomics Research Center, Academic Sinica, Taipei 115, - - 2014
A short G1 phase is a characteristic feature of the cell cycle structure of pluripotent cells, and is reestablished during Yamanaka factor-mediated pluripotent reprogramming. How cell cycle control is adjusted to meet the requirements of pluripotent cell fate commitment during reprogramming is less well understood. Elevated levels of cyclin D1 ...
Cao Liang - - 2014
BackgroundThe omentum is one of the initial sites for peritoneal metastasis because it possesses milky spots that provide a microenvironment for cancer cells to readily migrate and grow into micrometastases. This study investigated the role of the CCL22-CCR4 axis in gastric cancer cells selectively infiltrating into milky spots.MethodsGastric cancer MFC ...
Bar-Nur Ori O 1] Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [3] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [4] Department of Stem Cell and Regenerative Biology, Cambridge, Massachusetts, - - 2014
The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) upon overexpression of OCT4, KLF4, SOX2 and c-MYC (OKSM) provides a powerful system to interrogate basic mechanisms of cell fate change. However, iPSC formation with standard methods is typically protracted and inefficient, resulting in heterogeneous cell populations. We show ...
Amcheslavsky Alla A Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, - - 2014
Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine cells, in regulating intestinal stem cells remains unclear. We show here that newly eclosed scute ...
Tamari Keisuke K Department of Radiation Oncology, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, - - 2014
Osteosarcoma is the most common primary bone malignancy in pediatric and adolescent populations. Recurrence and metastatic potential can be due to a subpopulation of cells with stem cell-like characteristics, such as tumor-initiating cells (TICs), which maintain the capacity to regenerate entire tumors. Targeting the TICs in osteosarcoma is a promising ...
Hu Juan J Single-molecule Detection and Imaging Laboratory, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Guangdong 518055, China. - - 2014
We develop a simple and sensitive method for multiplex detection of lung cancer cells at the single-molecule level, with a detection limit of 15 cells per mL for A549 cells and 4 cells per mL for H23 cells, without the involvement of any sequence-based amplification. This method holds great potential ...
Burdak-Rothkamm Susanne S Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, UK, - - 2014
Radioprotective agents are of interest for application in radiotherapy for cancer and in public health medicine in the context of accidental radiation exposure. Methylproamine is the lead compound of a class of radioprotectors which act as DNA binding anti-oxidants, enabling the repair of transient radiation-induced oxidative DNA lesions. This study ...
Wu Lei L Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, 1 Minde Road, Nanchang, 330006, Jiangxi, People's Republic of - - 2014
Glioblastoma multiforme (GBM) is the prevalent and most fatal brain tumor in adults. Invasion and a high rate of recurrence largely contribute to the poor prognosis of GBM. The current standard therapy for GBM includes surgery with maximum feasible resection, radiotherapy, and treatment with chemotherapeutic agent temozolomide. Annexin A5 reportedly ...
Hernández-Coronado C G CG 1Departamento Producción Agrícola y Animal,Universidad Autónoma Metropolitana-Xochimilco,Calzada del Hueso 1100,CP 04960,México - - 2014
The follicle destiny towards ovulation or atresia is multi-factorial in nature and involves outcries, paracrine and endocrine factors that promote cell proliferation and survival (development) or unchain apoptosis as part of the atresia process. In several types of cells, sphingosine-1-phospate (S1P) promotes cellular proliferation and survival, whereas ceramide (CER) triggers ...
Yu Gan G Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and - - 2014
PTENP1 is a pseudogene of the PTEN tumor suppression gene (TSG). The functions of PTENP1 in clear cell renal cell carcinoma (ccRCC) have not yet been studied. We found that PTENP1 is down-regulated in ccRCC tissues and cells due to methylation. PTENP1 and PTEN are direct targets of microRNA miR-21 ...
English Diana P DP Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, - - 2014
Solitomab is a novel, bispecific, single-chain antibody that targets epithelial cell adhesion molecule (EpCAM) on tumor cells and also contains a cluster of differentiation 3 (CD3) (T-cell coreceptor) binding region. The authors evaluated the in vitro activity of solitomab against primary chemotherapy-resistant epithelial ovarian carcinoma cell lines as well as ...
Dou Yunling Y Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. - - 2014
Human pharyngeal squamous cell carcinoma (HNSCC) are highly invasive and proliferative and exhibit a poor five-year survival rate, mainly due to poor understanding of HNSCC pathogenesis mechanisms, preventing efficient treatment. Ubiquitin‑specific peptidase 22 (USP22) is an important component of cell cycle regulation, as it indirectly affects chromatin structure via histone ubiquitination ...
Li Jin J Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, Hunan 410078, P.R. - - 2014
In order to determine whether human parthenogenetic embryonic stem (hpES) cells have the potential to differentiate into functional cells, a modified four‑step protocol was used to induce the hpES cells into islet‑like clusters (ILCs) in vitro. Growth factors activin A, retinoic acid, nicotinamide, Exendin‑4 and betacellulin were added sequentially to the hpES cells at ...
Jiang Hao H Department of Toxicology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, - - 2014
1-Methylpyrene (1-MP) is a widespread pollutant that is carcinogenic in animals following metabolic activation. Previous studies have shown that benzylic hydroxylation of 1-MP, catalyzed by multiple CYP isoforms, gives rise to 1-hydroxymethylpyrene (1-HMP), which becomes bioreactive following further metabolism by various sulfotransferase (SULT) isoforms. However, the mutagenic and chromosome damaging ...
Lin Chin-Yin CY Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, - - 2014
Koelreuteria formosana ethanolic extract (KFEE) is obtained from natural plants that are endemic to Taiwan. In a previous study, it was demonstrated that KFEE inhibited low-density lipoprotein (LDL) and prevented oxidized LDL‑induced apoptosis in endothelial cells. In the present study, KFEE was shown to inhibit the invasion and migration of 786‑O‑SI3 renal cell carcinoma (RCC) cells while not ...
Lee Dong Hoon DH Department of Otorhinolaryngology - Head and Neck Surgery, Chonnam National University Medical School, Research Institute of Medical Sciences, Chonnam National University and Hwasun Hospital, Hwasun 519-809, Republic of - - 2014
Livin is one of the most important members of the inhibitor protein (IAP) family. It is overexpressed in several types of tumors and may have prognostic significance. The purpose of this study was to investigate Livin expression in human oral squamous cell carcinomas (OSCCs) and to determine whether Livin affects ...
Kaku Yoshiko - - 2014
The newly synthesized naftopidil analogue HUHS1015 reduced viability of MKN28 and MKN45 human gastric cancer cells in a concentration (0.3-100 µM)-dependent manner, with the potential greater than that for naftopidil. In the cell cycle analysis, HUHS1015 significantly increased the proportion at the subG1 phase of cell cycling in MKN28 cells. ...
Jonas Kristina K LOEWE Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, 35043 Marburg, Germany. Electronic address: - - 2014
A recent study shows that prolonged inhibition of bacterial cell division causes a block of DNA replication, which is followed by an irreversible cell cycle arrest. The finding indicates a tight coupling between cell division and DNA replication in bacteria.
Kong Dong D Laboratory of Protein Dynamics and Signaling, Center for Cancer Research-Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD - - 2014
Newly formed centrioles in cycling cells undergo a maturation process that is almost two cell cycles long before they become competent to function as microtubule-organizing centers and basal bodies. As a result, each cell contains three generations of centrioles, only one of which is able to form cilia. It is ...
Daum Gabor G Department of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, D-69120 Heidelberg, - - 2014
Cell-cell communication is essential for multicellular development and, consequently, evolution has brought about an array of distinct mechanisms serving this purpose. Consistently, induction and maintenance of stem cell fate by noncell autonomous signals is a feature shared by many organisms and may depend on secreted factors, direct cell-cell contact, matrix ...
Ono Yoshihiro J YJ Y Ono, Osaka Medical College, Obstetrics and Gynecology, Takatsuki, - - 2014
Dienogest, a synthetic progestin, was shown to be effective against endometriosis, although it is still unclear how it affects the ectopic endometrial cells. Decorin was shown to be a powerful endogenous tumor repressor acting in a paracrine fashion to limit tumor growth. Our objectives were to examine the direct effects ...
Rahman Atiqur A Department of Applied Chemistry and Chemical Technology, Islamic University, Kushtia 7003, Bangladesh. - - 2014
We examined the anticancer effect of limonin and imperatorin on various human cancer cells by MTT assay, and the results showed that imperatorin inhibited the cell growth of SNU 449 (liver cancer) and HCT-15 (colon cancer) cells in a dose-dependent manner, while limonin had less effect. Exposure of different concentrations ...
Xu Wenchao W Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P.R. China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P.R. - - 2014
Lung cancer is the leading cause of cancer mortality worldwide. A common interest in lung cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. There is increasing evidence that microRNAs (miRNAs) are involved in lung cancer. To explore new biomarkers of chemical exposure in risk assessment ...
Li Qifei Q Department of Biological Engineering, Utah State University, Logan, UT, - - 2014
Traditional approaches to characterize stem cell differentiation are time-consuming, lengthy and invasive. Here, Raman microspectroscopy (RM) and atomic force microscopy (AFM) - both considered as non-invasive techniques - are applied to detect the biochemical and biophysical properties of trophoblast derived stem-like cells incubated up to 10 days under conditions designed ...
Carmen Figueroa-Aldariz M M Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico D.F., - - 2014
Canonical Wnt signaling is altered in most cases of colorectal cancer. Experimental evidence indicates that protein phosphatase 2A (PP2A) may play either positive or negative roles in Wnt signaling but its precise in vivo functions remain elusive. In this work, using colon cultured cell lines we showed that basal PP2A ...
Zuryń Agnieszka A Department of Histology and Embryology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Karlowicza 24, 85-092 Bydgoszcz, - - 2014
Cyclin D1 drives cell cycle progression at the G1/S transition and is believed to play a significant role in tumorigenesis, contributing to efficient proliferation of many cancer cells. Consequently, it is also recognized as an end-point biomarker of therapeutic outcome for different treatment modalities in cancer. In this study we ...
Appukuttan Avinash A Department of Clinical Pharmacology, Ruhr-University Bochum, - - 2014
Pharmacological modulation of tumor radiosensitivity is a promising strategy for enhancing the outcome of radiotherapy. cAMP signaling plays an essential role in modulating the proliferation and apoptosis of different cell types, including cancer cells. Until now, the regulation of this pathway was restricted to the transmembrane class of adenylyl cyclases. ...
Maity Jyotirindra J Department of Life Science and Biotechnology, Jadavpur University, Kolkata, 700032, - - 2014
Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to normal cells. While the ...
Vergilio C S CS Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brazil, 28013-602. Electronic address: - - 2014
Mercury (Hg) is a highly toxic metal that can exert multiple adverse effects, ultimately leading to cell death. Before causing death, the Hg enters the cells and affects diverse intracellular targets. The present study aimed to investigate the structure and function of several organelles or cellular structures, including mitochondria, acidic ...
Yuan Qinghua Q Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR - - 2014
Background: In recent years, miRNAs have been suggested to play key roles in the formation and development of human glioma. The aim of this study is to investigate the effect and mechanism of miR-184 expression on the malignant behavior of human glioma cells. Methods: The relative quantity of miR-184 was ...
Feng Xiaohua X Department of Otolaryngology, General Hospital of Guangzhou Command, Guangzhou, - - 2014
Themetastasis-associated gene 1 (MTA1) oncogene hasbeen suggested to be involved in the regulation of cancer progression. However, there is still no direct evidence that MTA1 regulates cisplatin (CDDP) resistance, as well as cancer stem cell properties. In this study, we found that MTA1 was enriched in CNE1/CDDP cells. Knock down ...
Krehbiel Joel D JD Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, United - - 2014
Microbubbles were added to an algal solution with the goal of improving cell disruption efficiency and the net energy balance for algal biofuel production. Experimental results showed that disruption increases with increasing peak rarefaction ultrasound pressure over the range studied: 1.90 to 3.07MPa. Additionally, ultrasound cell disruption increased by up ...
Saeed Waqar Khalid WK Waqar Khalid Saeed, Dae Won Jun, Department of Gastroenterology, Hanyang University School of Medicine, Seoul 133-070, South - - 2014
Cell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ's physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, ...
Zhou Lili - - 2014
Background Many studies have demonstrated that microRNA-21 (miR-21) acts as an oncogene in the tumourigenesis of a variety of tumours and may be involved in the chemotherapeutic drug resistance of tumour cells. In this study, we utilized the leukaemia cell line K562 as an in vitro cell model to investigate ...
Jin Yue - - 2014
Abstract Purpose: The current study investigated the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. Methods: SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycle distribution. The ...
Li Aifeng A College of Environmental Science and Engineering, Ocean University of China, Qingdao, China, - - 2014
We reported previously that okadaic acid (OA) and dinophysistoxin-1 (DTX1) were responsible for diarrhetic shellfish poisoning (DSP) incidents due to consuming cultivated mussels (Mytilus galloprovincialis) in coastal cities near the East China Sea in May 2011. Pectenotoxin-2 (PTX2) and its seco acids were also present in these mussels. Causative species ...
Cankara Pirol Seyma S Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, - - 2014
We synthesized a series of novel amide derivatives of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid and assessed their antiproliferative activities against three human cancer cell lines (Huh7, human liver; MCF7, breast and HCT116, colon carcinoma cell lines) with the sulforhodamine B assay. Compound 4j with 2-chloro-4-pyridinyl group in the amide part exhibited promising cytotoxic ...
Ogbodu Racheal O RO Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South - - 2014
This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic ...
Becker Lindsey E LE Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY, 40202 - - 2014
Cancer is a multistep disease that begins with malignant cell transformation and frequently culminates in metastasis. MicroRNAs (miRNAs) are small regulatory 21-25-nt RNA molecules and are frequently deregulated in cancer. miR-200a is a member of the miR-200 family, which are known inhibitors of the epithelial to mesenchymal transition. As such, ...
Shanmugasundaram Revathi R Department of Animal Sciences, Ohio Agricultural Research and Development Center, Wooster, - - 2014
An experiment was conducted to identify the effect of whole yeast cell product supplementation in turkeys following an experimental inflammatory challenge. A total of 105 one-day-old turkey tom poults were fed basal diets supplemented with 0, 0.1, and 0.2% whole yeast cell product (CitriStim, ADM, Quincy, IL). At 6 wk ...
Yoon Jung Hwan JH Departments of Pathology, Sahmyook University, Hwarangro 815, Nowon-gu, Seoul 139-742, South - - 2014
Helicobacter pylori CagA directly injected by the bacterium into epithelial cells via a type IV secretion system, leads to cellular changes such as morphology, apoptosis, proliferation and cell motility, and stimulates gastric carcinogenesis. We investigated the effects of CagA and GKN1 on cell proliferation, apoptosis, ROS production, epithelial-mesenchymal transition (EMT), ...
Galluzzi L L 1] Gustave Roussy Cancer Center, Villejuif, France [2] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France [3] Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, - - 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, ...
Ellestad Kristofor K KK Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, - - 2014
The expression of the coinhibitor PD-1 on T cells is important for the establishment of immune homeostasis. We previously found that PD-1 is particularly critical for the control of self-tolerance during lymphopenia-induced proliferation (LIP) of recent thymic emigrants (RTEs). Previous studies suggested that PD-1 modulates the generation of Treg cells, ...
Vales Gerard G Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona , Bellaterra , Spain , - - 2014
Abstract There is a great interest in a better knowledge of the health effects caused by nanomaterials exposures and, in particular to those induced by titanium dioxide nanoparticles (nano-TiO2) due to its high use and increasing presence in the environment. To add new information on its potential genotoxic/carcinogenic risk, we ...
Kumashiro Yoshikazu Y Institute of Advanced Biomedical Engineering and Science (TWIns), Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, - - 2014
A stripe-patterned thermo-responsive surface is prepared to enable cell separation without labeling. The thermo-responsive surface containing a 3 μm striped pattern exhibits various cell adhesion and detachment properties. A mixture of three cell types is separated on the patterned surface based on their distinct cell-adhesion properties, and the composition of ...
Tanaka Tsutomu T Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodaicho, Nada, Kobe, 657-8501, - - 2014
In yeast cell-surface displays, functional proteins, such as cellulases, are genetically fused to an anchor protein and expressed on the cell surface. Saccharomyces cerevisiae, which is often utilized as a cell factory for the production of fuels, chemicals and proteins, is the most commonly used yeast for cell-surface display. To ...
Liao Cheng-Gong - - 2014
BackgroundRecently, miR-10b is identified as a miRNA highly expressed in many human cancers, promoting cell migration and invasion. However, the specific function of miR-10b in hepatocellular carcinoma (HCC) is unclear at this point.MethodsThe miR-10b expression levels in 60 paired different TNM Stage HCC tumor tissues compared with adjacent non-tumor (ANT) ...
Liu Shou-Sheng SS Department of Hematology, First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Second Road, 510080 Guangzhou, PR - - 2014
The aim of this study was to investigate the antitumor effect of zoledronic acid (ZOL) in the NB4 human acute promyelocytic leukemia (APL) cell line and explore the potential mechanism of action of this compound. NB4 cells were exposed to various concentrations (0-200μM) of ZOL. Cell viability was measured by ...
Arellano-Anaya Zaira E ZE INRA, UMR 1225, IHAP, 31076, Toulouse, - - 2014
Cell-to-cell transfer of prions is a crucial step in the spreading of prion infection through infected tissue. At the cellular level, several distinct pathways including direct cell-cell contacts and release of various types of infectious extracellular vesicles have been described that may potentially lead to infection of naïve cells. The ...
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