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Results 351 - 400 of 2028
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Carmen Figueroa-Aldariz M M Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico D.F., - - 2014
Canonical Wnt signaling is altered in most cases of colorectal cancer. Experimental evidence indicates that protein phosphatase 2A (PP2A) may play either positive or negative roles in Wnt signaling but its precise in vivo functions remain elusive. In this work, using colon cultured cell lines we showed that basal PP2A ...
Zuryń Agnieszka A Department of Histology and Embryology, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, Karlowicza 24, 85-092 Bydgoszcz, - - 2014
Cyclin D1 drives cell cycle progression at the G1/S transition and is believed to play a significant role in tumorigenesis, contributing to efficient proliferation of many cancer cells. Consequently, it is also recognized as an end-point biomarker of therapeutic outcome for different treatment modalities in cancer. In this study we ...
Appukuttan Avinash A Department of Clinical Pharmacology, Ruhr-University Bochum, - - 2014
Pharmacological modulation of tumor radiosensitivity is a promising strategy for enhancing the outcome of radiotherapy. cAMP signaling plays an essential role in modulating the proliferation and apoptosis of different cell types, including cancer cells. Until now, the regulation of this pathway was restricted to the transmembrane class of adenylyl cyclases. ...
Maity Jyotirindra J Department of Life Science and Biotechnology, Jadavpur University, Kolkata, 700032, - - 2014
Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to normal cells. While the ...
Vergilio C S CS Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brazil, 28013-602. Electronic address: - - 2014
Mercury (Hg) is a highly toxic metal that can exert multiple adverse effects, ultimately leading to cell death. Before causing death, the Hg enters the cells and affects diverse intracellular targets. The present study aimed to investigate the structure and function of several organelles or cellular structures, including mitochondria, acidic ...
Yuan Qinghua Q Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR - - 2014
Background: In recent years, miRNAs have been suggested to play key roles in the formation and development of human glioma. The aim of this study is to investigate the effect and mechanism of miR-184 expression on the malignant behavior of human glioma cells. Methods: The relative quantity of miR-184 was ...
Feng Xiaohua X Department of Otolaryngology, General Hospital of Guangzhou Command, Guangzhou, - - 2014
Themetastasis-associated gene 1 (MTA1) oncogene hasbeen suggested to be involved in the regulation of cancer progression. However, there is still no direct evidence that MTA1 regulates cisplatin (CDDP) resistance, as well as cancer stem cell properties. In this study, we found that MTA1 was enriched in CNE1/CDDP cells. Knock down ...
Krehbiel Joel D JD Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, United - - 2014
Microbubbles were added to an algal solution with the goal of improving cell disruption efficiency and the net energy balance for algal biofuel production. Experimental results showed that disruption increases with increasing peak rarefaction ultrasound pressure over the range studied: 1.90 to 3.07MPa. Additionally, ultrasound cell disruption increased by up ...
Saeed Waqar Khalid WK Waqar Khalid Saeed, Dae Won Jun, Department of Gastroenterology, Hanyang University School of Medicine, Seoul 133-070, South - - 2014
Cell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ's physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, ...
Zhou Lili - - 2014
Background Many studies have demonstrated that microRNA-21 (miR-21) acts as an oncogene in the tumourigenesis of a variety of tumours and may be involved in the chemotherapeutic drug resistance of tumour cells. In this study, we utilized the leukaemia cell line K562 as an in vitro cell model to investigate ...
Jin Yue - - 2014
Abstract Purpose: The current study investigated the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. Methods: SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycle distribution. The ...
Li Aifeng A College of Environmental Science and Engineering, Ocean University of China, Qingdao, China, - - 2014
We reported previously that okadaic acid (OA) and dinophysistoxin-1 (DTX1) were responsible for diarrhetic shellfish poisoning (DSP) incidents due to consuming cultivated mussels (Mytilus galloprovincialis) in coastal cities near the East China Sea in May 2011. Pectenotoxin-2 (PTX2) and its seco acids were also present in these mussels. Causative species ...
Cankara Pirol Seyma S Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, - - 2014
We synthesized a series of novel amide derivatives of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid and assessed their antiproliferative activities against three human cancer cell lines (Huh7, human liver; MCF7, breast and HCT116, colon carcinoma cell lines) with the sulforhodamine B assay. Compound 4j with 2-chloro-4-pyridinyl group in the amide part exhibited promising cytotoxic ...
Ogbodu Racheal O RO Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South - - 2014
This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic ...
Becker Lindsey E LE Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY, 40202 - - 2014
Cancer is a multistep disease that begins with malignant cell transformation and frequently culminates in metastasis. MicroRNAs (miRNAs) are small regulatory 21-25-nt RNA molecules and are frequently deregulated in cancer. miR-200a is a member of the miR-200 family, which are known inhibitors of the epithelial to mesenchymal transition. As such, ...
Shanmugasundaram Revathi R Department of Animal Sciences, Ohio Agricultural Research and Development Center, Wooster, - - 2014
An experiment was conducted to identify the effect of whole yeast cell product supplementation in turkeys following an experimental inflammatory challenge. A total of 105 one-day-old turkey tom poults were fed basal diets supplemented with 0, 0.1, and 0.2% whole yeast cell product (CitriStim, ADM, Quincy, IL). At 6 wk ...
Yoon Jung Hwan JH Departments of Pathology, Sahmyook University, Hwarangro 815, Nowon-gu, Seoul 139-742, South - - 2014
Helicobacter pylori CagA directly injected by the bacterium into epithelial cells via a type IV secretion system, leads to cellular changes such as morphology, apoptosis, proliferation and cell motility, and stimulates gastric carcinogenesis. We investigated the effects of CagA and GKN1 on cell proliferation, apoptosis, ROS production, epithelial-mesenchymal transition (EMT), ...
Galluzzi L L 1] Gustave Roussy Cancer Center, Villejuif, France [2] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France [3] Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, - - 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, ...
Ellestad Kristofor K KK Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, - - 2014
The expression of the coinhibitor PD-1 on T cells is important for the establishment of immune homeostasis. We previously found that PD-1 is particularly critical for the control of self-tolerance during lymphopenia-induced proliferation (LIP) of recent thymic emigrants (RTEs). Previous studies suggested that PD-1 modulates the generation of Treg cells, ...
Vales Gerard G Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona , Bellaterra , Spain , - - 2014
Abstract There is a great interest in a better knowledge of the health effects caused by nanomaterials exposures and, in particular to those induced by titanium dioxide nanoparticles (nano-TiO2) due to its high use and increasing presence in the environment. To add new information on its potential genotoxic/carcinogenic risk, we ...
Kumashiro Yoshikazu Y Institute of Advanced Biomedical Engineering and Science (TWIns), Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, - - 2014
A stripe-patterned thermo-responsive surface is prepared to enable cell separation without labeling. The thermo-responsive surface containing a 3 μm striped pattern exhibits various cell adhesion and detachment properties. A mixture of three cell types is separated on the patterned surface based on their distinct cell-adhesion properties, and the composition of ...
Tanaka Tsutomu T Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodaicho, Nada, Kobe, 657-8501, - - 2014
In yeast cell-surface displays, functional proteins, such as cellulases, are genetically fused to an anchor protein and expressed on the cell surface. Saccharomyces cerevisiae, which is often utilized as a cell factory for the production of fuels, chemicals and proteins, is the most commonly used yeast for cell-surface display. To ...
Liao Cheng-Gong - - 2014
BackgroundRecently, miR-10b is identified as a miRNA highly expressed in many human cancers, promoting cell migration and invasion. However, the specific function of miR-10b in hepatocellular carcinoma (HCC) is unclear at this point.MethodsThe miR-10b expression levels in 60 paired different TNM Stage HCC tumor tissues compared with adjacent non-tumor (ANT) ...
Liu Shou-Sheng SS Department of Hematology, First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Second Road, 510080 Guangzhou, PR - - 2014
The aim of this study was to investigate the antitumor effect of zoledronic acid (ZOL) in the NB4 human acute promyelocytic leukemia (APL) cell line and explore the potential mechanism of action of this compound. NB4 cells were exposed to various concentrations (0-200μM) of ZOL. Cell viability was measured by ...
Arellano-Anaya Zaira E ZE INRA, UMR 1225, IHAP, 31076, Toulouse, - - 2014
Cell-to-cell transfer of prions is a crucial step in the spreading of prion infection through infected tissue. At the cellular level, several distinct pathways including direct cell-cell contacts and release of various types of infectious extracellular vesicles have been described that may potentially lead to infection of naïve cells. The ...
Jiang Lizhu L Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University , 1 Youyi Road, 400016 Chongqing , P.R. - - 2014
Abstract Background. The forkhead box M1 (FOXM1) transcription factor plays an important role in the metastases of many cancers. Down-regulation of FOXM1 by its inhibitor, thiostrepton, can inhibit the metastatic potential of some cancers; however, there are few studies regarding the functional significance of FOXM1 and thiostrepton in the metastases ...
Li Sixing S Department of Engineering Science and Mechanics, The Pennsylvania State University , University Park, Pennsylvania 16802, United - - 2014
Precise reconstruction of heterotypic cell-cell interactions in vitro requires the coculture of different cell types in a highly controlled manner. In this article, we report a standing surface acoustic wave (SSAW)-based cell coculture platform. In our approach, different types of cells are patterned sequentially in the SSAW field to form ...
Dong Juan J Key Laboratory for Renewable Energy, Chinese Academy of Sciences (CAS), Beijing Key Laboratory for New Energy Materials and Devices, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, CAS, Beijing 100190, P. R. China. - - 2014
Al-doped ZnO (AZO) modified ZnO nanorods have been applied in CH3NH3PbI3 perovskite solar cells, which can show a positive effect on open circuit voltage and power conversion efficiency. The average power conversion efficiency is improved from 8.5% to 10.07% and the maximum efficiency reaches 10.7%.
Xiong Wei W 1] Department of Molecular and Cellular Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California, USA. - - 2014
Mechanosensation, the transduction of mechanical force into electrochemical signals, allows organisms to detect touch and sound, to register movement and gravity, and to sense changes in cell volume and shape. The hair cells of the mammalian inner ear are the mechanosensors for the detection of sound and head movement. The ...
Choi Du Seok DS University of California - - 2014
Formate dehydrogenase (FDH; EC 1.2.1.2) is a nicotinamide adenine dinucleotide (NAD)-dependent enzyme that catalyzes the oxidation of formate to carbon dioxide. Here, we report the identification and characterization of pepper (Capsicum annuum) mitochondrial FORMATE DEHYDROGENASE1 (FDH1) as a positive regulator of cell death and defense responses. Transient expression of FDH1 ...
Zhang Zhitao Z State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438, - - 2014
Power yourself up: a sweater made from solar cells! Stretchable and wearable fibers are shown to be highly efficient polymer solar cells. Their stable energy conversion efficiency variation is below 10% even after 1000 bending cycles or stretching under a strain of 30%. These fibers can easily be woven into ...
Amann P M PM RWTH Aachen University, Department of Dermatology and Allergology, Aachen, - - 2014
Retinoids such as all-trans retinoic acid (ATRA) influence cell growth, differentiation and apoptosis and may play decisive roles in tumor development and progression. An essential retinoid-metabolizing enzyme known as lecithin retinol acyltransferase (LRAT) is expressed in melanoma cells but not in melanocytes catalysing the esterification of all-trans retinol (ATRol). In ...
Soliño Lucia L IRTA, Marine Monitoring Subprogram, Ctra. Poble Nou, Km 5.5, 43540 Sant Carles de la Ràpita, Tarragona, Spain; Universitat Rovira i Virgili, Faculty of Medicine & Health Sciences, Pharmacology Unit, c./ St. Llorenç 21, 43201 Reus, Tarragona, - - 2014
Marine dinoflagelates from the genus Dynophisis are important producers of Diarrhetic Shellfish Poisoning (DSP) toxins which are responsible for human intoxications. The present work is an approach to study the relative toxicity of DSP toxins effects on Neuro-2a, NG108-15 and MCF-7 cell-lines. Certified standards of okadaic acid (OA), dinophysistoxin-1 (DTX-1) ...
Liu Bin B Laboratory of Medical Molecular Virology, School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China. Electronic address: - - 2014
Increasing evidence indicates that HIV-1 infection has an impact on cell autophagy, and a susceptible cell line is required for studying the relationship of HIV-1 with autophagy. However, there is limited information on the optimal cell line to evaluate the changes of autophagy affected by HIV infection. In this study ...
Yamamoto Eriko E Department of Obstetrics and Gynecology, Juntendo University, Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, - - 2014
Autophagy is a tightly regulated self-digestion system. As in other cell types, autophagy plays an essential role in the homeostasis of pancreatic beta cells. However, the mechanisms involved in the deterioration of beta cell function caused by autophagic failure have not yet been fully elucidated. To gain insight into its ...
Ding Yajie - - 2014
Wnt/β-catenin signaling via the β-catenin/TCF complex plays crucial roles in tissue homeostasis. Wnt stimulated β-catenin/TCF complex accumulation in the nucleus regulates cell survival, proliferation, and differentiation through the transcription of target genes. Compared with those in G1, LRP6 receptor activation and cytosolic β-catenin are both up-regulated in G2 cells. However, ...
Mouchet Nicolas N Genetic and Development Institute of Rennes (CNRS-UMR6290), University of Rennes I, Rennes, - - 2014
Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer that is predominantly caused by infection by the Merkel cell polyomavirus. The cell of origin for MCC is still debated because conflicting data suggest that MCC cells could be derived from Merkel cells (MCs) [1] or their ...
Battistini F D FD Departamento de Farmacia. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Ciudad Universitaria. X5000HUA Córdoba, Argentina. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET). Córdoba, - - 2014
We report Doxorubicin ionic complexes with hyaluronic acid (HiH-Dx) or its sodium salt (HiNa-Dx) as tumor-targeting delivery system. The complexes were prepared in situ by mixing aqueous solutions of Dx.HCl with HiH or HiNa. Clear colloidal dispersions with a high degree of counterionic condensation (cc) were obtained. Affinity constants (log ...
Fan Li L Department of Obstetrics and Gynecology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, - - 2014
The polyphenolic flavonoid silymarin that is the milk thistle extract, has been found to possess an anti-cancer effect against various human epithelial cancers. In this study, to explore the regulative effect of silymarin on human ovarian cancer line A2780s and PA-1 cells, 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide assay and flow cytometry ...
Keplinger T T ETH Zurich, Institute for Building Materials, Zurich Switzerland; Empa - Swiss Federal Laboratories for Material Testing and Research, Applied Wood Research Laboratory, Dübendorf, - - 2014
The hierarchical structure of wood is composed of a cellulose skeleton of high structural order at various length scales. At the nano- and microscale the specific structural features of the cells and cell walls result in a lightweight structure with an anisotropic material profile of excellent mechanical performance. By being ...
Liu Xuemin X Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, - - 2014
Hepatocellular carcinoma (HCC) ranks as the third leading cause of tumor-related mortality worldwide. Recently, syntenin was found to be upregulated in several tumors and to exert pivotal roles in the development of cancer. However, its function and the underlying mechanism in HCC remain to be defined. In the present study, ...
Zhang Guofeng G Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, 200065, Shanghai, China, - - 2014
Increased expression of Pituitary Tumor Transforming Gene 1 (Pttg1) has been shown in various tumor cells, including breast cancer (BC). However, the precise role of Pttg1 in the tumorigenesis is not clarified yet. Here, we examined BC from the patients and detected significant increases and correlation in Pttg1 and phosphorylated ...
Meng Gang G Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, - - 2014
Methyl-CpG-binding protein 2 (MeCP2) is a DNA methylation-related gene of the methyl-CpG-binding protein family. Here, we investigated the epigenetic function of the MeCP2 in SaOS2 and U2OS cell lines, and explored the antitumor effects of the gene silencing for osteosarcoma. In this study, chromatin immunoprecipitation assay was used to detect ...
Toh Pey Yi PY School of Chemical Engineering, Universiti Sains Malaysia, Nibong Tebal, Penang 14300, Malaysia. - - 2014
Successful application of a magnetophoretic separation technique for harvesting biological cells often relies on the need to tag the cells with magnetic nanoparticles. This study investigates the underlying principle behind the attachment of iron oxide nanoparticles (IONPs) onto microalgal cells, Chlorella sp. and Nannochloropsis sp., in both freshwater and seawater, ...
Tajima Shogo S Department of Pathology, Shizuoka Saiseikai General Hospital, Shizuoka, - - 2014
We present two cases of extensive goblet cell metaplasia in the peripheral lung. The first case was a 72-year-old male with a nodule (12 × 10 mm) detected by CT. Macroscopically, it contained abundant mucin; histopathologically, goblet cells were predominant, whereas ciliated and basal cells were sparse. A KRAS G12V mutation was ...
Wang Hongyan H Department of Radiation Oncology, School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia - - 2014
Ionizing radiation kills cells mainly due to the generation of DNA double-strand breaks (DSBs). High-linear energy transfer (LET) ionizing radiation induces more cell death and generates a higher relative biological effect (RBE) than low-LET ionizing radiation (such as X or γ ray). Although it is known that interference with the ...
Sato Katsutoshi K a  Cancer Metastasis Research - - 2014
Although it is known that cancer cells can develop radiation resistance after repeated exposures to X rays, the underlying mechanisms and characteristics of this radiation-induced resistance of cancer cells are not well understood. Additionally, it is not known whether cells that develop X-ray resistance also would develop resistance to other ...
Eckers Jaimee C JC a  Free Radical and Radiation Biology Division, Department of Radiation Oncology, - - 2014
Cellular quiescence is a reversible growth arrest in which cells retain their ability to enter into and exit from the proliferative cycle. This study investigates the hypothesis that cell growth-state specific oxidative stress response regulates radiosensitivity of cancer cells. Results showed that quiescent (low proliferative index; >75% G1 phase and ...
Carneiro Renê G S RG Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, - - 2014
The temporal balance between hyperplasia and hypertrophy, and the new functions of different cell lineages led to cell transformations in a centrifugal gradient that determines the gall globoid shape. Plant galls develop by the redifferentiation of new cell types originated from those of the host plants, with new functional and ...
Wu Qing Q Department of Respiratory Medicine, Guangxing Hospital, Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, People's Republic of China, - - 2014
Deregulation of centromere protein (CENP)-A, a centromere-specific histone variant, has in the past been linked to cancer initiation and progression. Additionally, our previous work has shown that CENP-A upregulation predicts a poor overall survival in patients with lung adenocarcinoma. The aim of this study was to uncover the biological role ...
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