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Results 301 - 350 of 2623
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Tsiantoulas Dimitrios D From the Department of Laboratory Medicine, Medical University of Vienna, Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria (D.T., C.J.B.); and Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S., - - 2014
Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main families: the B1 and the B2 cells. B1 cells are atheroprotective mainly via the production of natural IgM antibodies that bind oxidized low-density lipoprotein and apoptotic cells. ...
Satué María M Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS). University of Balearic Islands, Palma de Mallorca, - - 2014
The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on metabolic activity ...
Graupner Anne A Department of Chemicals and Radiation, National Institute of Public Health, Oslo 0456, Norway,Department of Plant and Environmental Sciences, University of Life Sciences, Aas 1430, Norway, andLitron Laboratories, Rochester, NY 14623, - - 2014
Many studies have investigated genotoxic effects of high Se diets but very few have addressed the genotoxicity of Se deprivation and its consequences in germ cells and none in somatic cells. To address these data gaps, C57BL/6 male mice were subjected to Se deprivation starting in the parental generation, i.e. ...
Du Feng F Department of Nephrology, Shengjing Hospital, China Medical University, Shenyang 110004, China - - 2014
The epithelial-mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like cells plays a substantial role in renal tubulointerstitial fibrosis, which is a common pathological character of end-stage renal disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT in tubular epithelial cells and increases Bcl-2-associated athanogene 3 (BAG3) expression in neural progenitor ...
Gargiulo Lucía L Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490, C1428ADN, CABA, - - 2014
Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast ...
Matoba Shogo S Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, - - 2014
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT embryos fail to develop to term due to undefined reprogramming defects. Here, we identify histone H3 lysine 9 trimethylation (H3K9me3) of donor cell genome as a ...
Chanvorachote Pithi P Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand, - - 2014
Caveolin-1 (Cav-1), a protein component of cellular membrane, has been reported to regulate several cancer cell behaviors. However, its role on cancer metastasis in anoikis resistant cells is unknown. The present study aimed to investigate the correlation between Cav-1 level and aggressive behaviors of anoikis resistant cancer cells. Cav-1 and ...
He Youdi Y Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. - - 2014
Mounting evidence has suggested that inflammation associated with interleukin (IL)‑6 and T‑helper (Th)17 cells, has a role in the development of atherosclerotic cerebral infarction (ACI). However, it remains unclear which population of cells determines the levels of IL‑6, and the role of IL‑6‑secreting cells in inducing Th17 cell production. In the present ...
Choi Soon Won SW Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of - - 2014
The retinal pigment epithelium (RPE) is a highly specialized cell type located between the choroid and neural retina of the eye. RPE degeneration causes irreversible visual impairment, extending to blindness. Cell therapy has recently emerged as a potential therapeutic approach for retinal degeneration. MicroRNA-based differentiation of stem cells is a ...
Yan Xiaomin X State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. - - 2014
Triptolide is a diterpene triepoxide, extracted from the Chinese herb Tripterygium wilfordii Hook F, which has been shown to have antitumor activity in a number of cancers. Neuroblastoma is an aggressive extracranial pediatric solid tumor, with significant chemotherapeutic resistance. In this study, triptolide was hypothesized to be a potential therapeutic ...
Zhou Zhou Z Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, - - 2014
The functions of the actin-myosin-based contractile ring in cytokinesis remain to be elucidated. Recent findings show that in the fission yeast Schizosaccharomyces pombe, cleavage furrow ingression is driven by polymerization of cell wall fibers outside the plasma membrane, not by the contractile ring. Here, we show that one function of ...
Xiao Wenkai W Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. - - 2014
Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to inhibit tumor cell proliferation and induce apoptosis in cancer models in vitro and in vivo. In the present study, tetrandrine significantly inhibited the proliferation of mouse endothelial cells (EOMA cell) and induced G1/S arrest in EOMA cells, in which the expressions of cyclin D and cyclin E ...
Yin Jirong J Dental Institute, Chinese PLA General Hospital, Beijing 100853, P.R. - - 2014
Zinc finger protein, X-linked (ZFX) has been identified as a transcriptional factor and is implicated in the development of variant types of cancer. Furthermore, it has been reported that ZFX is essential for the survival and self-renewal of embryonic stem cells. To investigate the involvement of ZFX in squamous cell ...
Berger Carolina C Clinical Research Division - Program in Immunology, Fred Hutchinson Cancer Research Center - - 2014
Genetic engineering of T cells for adoptive transfer by introducing a tumor-targeting chimeric antigen receptor (CAR) is a new approach to cancer immunotherapy. A challenge for the field is to define cell surface molecules that are both preferentially expressed on tumor cells and can be safely targeted with T cells. ...
Mitchell Ryan K RK Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, - - 2014
Type 2 diabetes (T2D) is characterised by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. Whilst deletion of the homologous murine Tcf7l2 gene throughout the developing pancreas leads to ...
Del Nagro Christopher C Genentech, United - - 2014
Depletion of the central metabolite NAD in cells results in broad metabolic defects leading to cell death and is a proposed novel therapeutic strategy in oncology. There is however a limited understanding of the underlying mechanisms that connect disruption of this central metabolite with cell death. Here we utilize GNE-617, ...
Morimoto Ayumi A Department of Clinical Laboratory, Toki General Hospital, Toki, - - 2014
Objective: To evaluate the expression of antibodies against calretinin, cytokeratin 5/6, desmin, D2-40, HBME-1, mesothelin, thrombomodulin, WT1, Ber-EP4, CEA, EMA and MOC-31 individually and to compare it with a new rapid procedure for fluorescence immunocytochemistry (ICC) using liquid-based cytology (LBC). Study Design: Sixty-four peritoneal cell specimens prepared with the LBC ...
Luo Qingquan Q Nanjing Medical University, Nanjing, 210029, - - 2014
Trim44 is an important member of the tripartite motif-containing protein (TRIM) family. Recent research reported that Trim44 might play an important role in tumorigenesis, although its role in non-small cell lung cancer (NSCLC) and the related mechanisms is not yet known. In this study we analyzed 30 pairs of NSCLC ...
Wu Yuanyuan Y State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China, - - 2014
The Aurora kinase family, as a group of serine/threonine kinases regulating cell cycles, are frequently overexpressed or amplified in human tumors. Here, we showed that the small molecule S4 could inhibit Aurora kinase in both of biochemincal and cell-based levels. The Aurora B inhibition of S4 treatment inhibited the phosphorylation ...
Plouffe Brian D - - 2014
The purification and sorting of cells using microfluidic methodologies has been a remarkably active area of research over the last decade. Much of the scientific and technological work associated with microfluidic cell separation has been driven by needs in clinical diagnostics and therapeutic monitoring, most notably in the context of ...
Martínez-Ramos Cristina C Center for Biomaterials and Tissue Engineering, Universitat Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia, - - 2014
Background: Cancer research focuses increasingly on cancer stem cell study as those cells are thought to be the root of chemo and radioresistance of the most aggressive cancer types. Nevertheless, two-dimensional (2D) cell culture and even three-dimensional (3D) spheroid models, with their limited ability to reflect cell-extracellular matrix interactions, are ...
Liu Ming-Ming - - 2014
Sixteen furoxan-based nitric oxide (NO) releasing coumarin derivatives (6a-c, 8a-g, 10a, 13a-b, 15 and 17a-b) were designed, synthesized and evaluated against the A549, Hela, A2780, A2780/CDDP and HUVEC cell lines. Most derivatives displayed potent anti-proliferation activities. Among them, 8b exhibited the strongest anti-proliferation activity on the four sensitive cell lines ...
Lamour Guillaume G Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 Rue des Saints-Pères, 75006, Paris, - - 2014
Nanoscale gradients in energy of adhesion are physical cues from the extracellular environment that can significantly affect cell functions and enhance the neuronal differentiation of PC12 cells. How such surface effects can trigger differentiation and initiate neurite outgrowth, remains to be elucidated. Here we used surface modification, atomic force microscopy ...
Hamouda Houda - - 2014
Cell surfaces are covered with a dense carbohydrate layer referred to as the glycocalyx. Since different cell types express different glycan signatures, it is of paramount importance to have robust methods to analyze the glycome of living cells. The common procedure involves first cell lysis and extraction of membranes (glyco)proteins ...
Kobayashi Mari M Joint Graduate School of Tokyo Women's Medical University and Waseda University, Shinjuku-ku, Tokyo, 162-8666, Japan; Panasonic Healthcare, Nishi-shinbashi MF Bldg, Minato-ku, Tokyo, 105-8433, - - 2014
Cell sheet technology has a history of application in regenerating various tissues, having successfully completed several clinical trials using autologous cell sheets. Tomographic analysis of living cell sheets is an important tool in the field of cell sheet-based regenerative medicine and tissue engineering to analyze the inner structure of layered ...
Milić Mirta M Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000, Zagreb, - - 2014
The rapid progress and early commercial acceptance of silver-based nanomaterials is owed to their biocidal activity. Besides embracing the antimicrobial potential of silver nanoparticles (AgNPs), it is imperative to give special attention to the potential adverse health effects of nanoparticles owing to prolonged exposure. Here, we report a detailed study ...
Morabito Rossana - - 2014
Marine animals represent a good model for toxicological investigations, being a source of novel bioactive substances considered as a suitable research tool. Among stinging animals, Cnidarians possess specialized cells, termed nematocytes, containing an inverted tubule and toxins, synergistically responsible for mechanisms of defence and predation. Such compounds include proteins and ...
Tada Yukiyo Y Division of Molecular Signaling and Biochemistry, Department of Health Promotion, Kyushu Dental University, Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, Japan. Division of Dental Anesthesiology, Department of Control of Physical Functions, Kyushu Dental University, Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, - - 2014
Oral squamous cell carcinoma (OSCC) cells display significantly augmented nuclear factor-κB (NF-κB) activity, and inhibiting this activity suppresses malignant tumor characteristics. Thus, we evaluated the effect of IMD-0560, a novel inhibitor of IκB kinase (IKK) β that is under assessment in a clinical trial of rheumatoid arthritis, on bone invasion ...
Su Ke K Division of Nephrology, Renmin Hospital of Wuhan University , Wuhan, Hubei , People's Republic of China - - 2014
Abstract PCBs are a family of persistent environmental toxicants with a wide spectrum of toxic features, such as neurotoxic, hepatoxicity, immunotoxicity, endocrine disruption effects, and oncogenic effects. The kidney is the most important organ involved in the elimination of toxins and drugs. To date, little has been done to investigate ...
Buccoliero Anna Maria - - 2014
Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal cortical dysplasia IIb. In all cases, balloon cells, ...
Kim Bo Geun - - 2014
Though herbal medicines have been used for cancer prevention and treatment, their scientific evidences still remain unclear so far. Thus, complementary and alternative medicine (CAM) project has been actively executed to reveal the scientific evidences in the USA and other countries. In the present study, we elucidated antitumor mechanism of ...
Sage Peter T - - 2014
Follicular Tregs (Tfr cells) inhibit antibody production, whereas follicular Th cells (Tfh cells) stimulate it. Tfr cells are found in blood; however, relatively little is known about the developmental signals for these cells or their functions. Here we demonstrated that circulating Tfr and Tfh cells share properties of memory cells ...
Hu J J Department of Pathology, University of California San Diego, La Jolla, CA, - - 2014
In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly. In many GBMs, a truncated form of the EGFR (EGFRvIII) is expressed. Although EGFRvIII is constitutively ...
Ragkousi Katerina K Stowers Institute for Medical Research, Kansas City, MO - - 2014
Epithelia are polarized layers of adherent cells that are the building blocks for organ and appendage structures throughout animals. To preserve tissue architecture and barrier function during both homeostasis and rapid growth, individual epithelial cells divide in a highly constrained manner. Building on decades of research focused on single cells, ...
Tian Jihua J Department of Nephrology, The Affiliated People's Hospital of Shanxi Medical University, Shanxi Provincial People's Hospital, Shanxi Kidney Disease Institute, Taiyuan, Shanxi, 030012, China Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi, 030001, - - 2014
IgA nephropathy is the most frequent type of glomerulonephritis worldwide. The role of cell cycle regulation in the pathogenesis of IgA nephropathy has been studied. The present study was designed to explore whether rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms. After establishing an IgA nephropathy model, rats were randomly ...
Matsuoka Yosuke Y Department of Medical Genetics, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565-0871, - - 2014
Enterocyte shedding in the small intestine is often referred as an example of programmed cell death. However, little is known about the underlying mechanisms, although both apoptotic and nonapoptotic cell death have been suggested to play an important role. Here, we show by electron microscope that the majority of cells ...
Song Yuwen Y Department of Neurosurgery, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, - - 2014
Glioma is one of the most highly angiogenic tumors, and glioma stem cells (GSCs) are responsible for resistance to chemotherapy and radiotherapy, as well as recurrence after operation. Stathmin is substantial for mitosis and plays an important role in proliferation and migration of glioma-derived endothelial cells. However, the relationship between ...
Yang Z Z Department of Breast and Thyroid Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, 256603, - - 2014
miR-99a has been reported to function as a tumour suppressor in breast cancer. However, its role in the regulation of breast cancer stem cell (CSC) phenotype has up to now remained unknown. In this study, we isolated the side population (SP) cells by staining cultured MCF-7 and MDA-MB-231 cells with ...
Liu Qun Q Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, P.R. - - 2014
The development of acquired drug resistance is the primary cause of chemotherapy failure in the treatment of ovarian cancer. To examine the mechanism underlying Taxol (TAX) resistance in ovarian cancer and attempt to reverse it, the present study induced a TAX‑resistant ovarian cancer cell line SKOV3/TAX using a gradient concentration ...
Fischer Trevan D TD Trevan D Fischer, Jin-Hee Wang, Adrian Vlada, Jae-Sung Kim, Kevin E Behrns, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, United - - 2014
To investigate the role of sorafenib (SFN) in autophagy of hepatocellular carcinoma (HCC). We evaluated how SFN affects autophagy signaling pathway in human HCC cell lines. Two different human HCC cell lines, Hep3B and Huh7, were subjected to different concentrations of SFN. Cell viability and onset of apoptosis were determined ...
Guo Zhongqiang Z Department of Urology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing, 100034, - - 2014
Potassium inwardly rectifying channel, subfamily J, member 1 (KCNJ1), as an ATP-dependent potassium channel, plays an essential role in potassium balance. KCNJ1 variation is associated with multiple diseases, such as antenatal Bartter syndrome and diabetes. However, the role of KCNJ1 in clear cell renal cell carcinoma (ccRCC) is still unknown. ...
Klimaszewska-Łata Joanna J Department of Laboratory Medicine, Medical University of Gdańsk, - - 2014
There are significant differences between acetyl-CoA and ATP levels, enzymes of acetyl-CoA metabolism and toll-like receptor 4 contents in non-activated microglial N9 and non-differentiated cholinergic SN56 neuroblastoma cells. Exposition of N9 cells lipopolysaccharide caused concentration-dependent several-fold increases of nitrogen oxide synthesis, accompanied by inhibition of pyruvate dehydrogenase complex, aconitase and ...
Israël Maurice M , 2 av.Aristide Briand, 91440, Bures sur Yvette, France, - - 2014
Tumor cells display hybrid metabolic features: some of their enzymes are phosphorylated as normally observed when catabolic hormones stimulate Gs-coupled receptors, whereas other enzymes adopt a configuration normally found in anabolic situations, mediated via tyrosine kinase receptors. Consequently, tumor cells have to rewire their metabolic pathways differently, whereas differentiated cells ...
Lu Zhaoyang - - 2014
Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. FTY720, a new immunosuppressant, derived from ISP-1, has been studied for its putative anti-cancer properties. This study aimed ...
Hansakul Pintusorn - - 2014
Dioscoreanone (DN) isolated from Dioscorea membranacea Pierre has been reported to exert potent cytotoxic effects against particular types of cancer. The present study was carried out to investigate the cytotoxicity of DN against a panel of different human lung cancer cell lines. The study further examined the underlying mechanisms of ...
Gao Xiaohua X Molecular Pathogenesis Group, National Toxicology Program (NTP) Laboratory, Division of the NTP (DNTP), National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, - - 2014
It is proposed that cadmium (Cd) is an environmental "metalloestrogen" and its action is mediated via the estrogen receptor (ER). Cd mimics the effects of estrogen in the rat uterus, and blood Cd concentrations positively correlate with ER levels in uteri of women with fibroids. This study explored whether Cd ...
Sun Ranran R Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, 1 Jianshendong Road, Zhengzhou, 450000, - - 2014
Autophagy is a cellular degradation process for the clearance of damaged or superfluous proteins and organelles, the recycling of which serves as an alternative energy source during periods of metabolic stress to maintain cell homeostasis and viability. The anti-necrotic function of autophagy is critical for tumorigenesis of many tumor cells, ...
Kroemer Guido G 1] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, F-75006 Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, F-75005 Paris, France [3] Metabolomics and Cell Biology Platforms, Gustave Roussy, F-94805 Villejuif, France [4] Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75015 Paris, - - 2014
Cell-in-cell structures, also referred to as 'entosis', are frequently found in human malignancies, although their prognostic impact remains to be defined. Two articles recently published in Cell Research report the stimulation of entosis by one prominent oncogene, Kras, as well as by one class of tumor suppressors, namely epithelial cadherins ...
Sun Qiang Q 1] Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA [2] Laboratory of Cell Engineering, Institute of Biotechnology, Beijing 100071, - - 2014
Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of ...
Sun Qiang Q 1] Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA [2] Laboratory of Cell Engineering, Institute of Biotechnology, Beijing 100071, - - 2014
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an ...
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