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McDonald Courtney A - - 2014
Preterm newborns often, require mechanical respiratory support that can result in ventilation-induced lung injury (VILI), despite exogenous surfactant treatment. Human amnion epithelial cells (hAECs) reduce lung inflammation and resultant abnormal lung development in preterm animals; co-administration with surfactant is a potential therapeutic strategy. We aimed to determine whether hAECs remain ...
Frisco-Cabanos Heidie L HL Institute for Integrated Cell-Material Sciences (WPI-iCeMS) and Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011 (Japan); Graduate School of Medicine Kyoto University - - 2014
One of the major problems encountered in cell transplantation is the low level of survival of transplanted cells due to detachment-induced apoptosis, called anoikis. The present study reports on the chemical synthesis and biological evaluation of water-soluble molecules that protect suspended cells from anoikis. The synthetic molecules bind to and ...
George Isabelle I Univ Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology (BFA) (BFA) UMR 8251 CNRS, F-75205, Paris, France. Electronic address: - - 2014
Inhalation is the most frequent route of unintentional exposure to nanoparticles (NPs). Our aim was to compare different in vitro models of human lung epithelial monolayers for their suitability to assess the translocation of 50 nm fluorescently labelled silica NPs (50 nm-SiO2-FITC-NPs). Human bronchial epithelial cell lines NCI-H292 and Calu-3 ...
Kawanishi Kunio K Department of Medicine, Kidney Center, Tokyo, - - 2014
Mesothelial cells are an integral part of the peritoneum and play an important role in maintaining its structural and functional properties. In recent years a number of studies on mesothelial cells have been performed to evaluate the localization, secretional properties and the ability of regeneration and transdifferentiation of these cells. ...
Herce Henry D HD Department of Biology; Technische Universität Darmstadt; Darmstadt, - - 2014
Proliferating Cell Nuclear Antigen (PCNA) is a key protein in DNA replication and repair. The dynamics of replication and repair in live cells is usually studied introducing translational fusions of PCNA. To obviate the need for transfection and bypass the problem of difficult to transfect and/or short lived cells, we ...
Riihilä Pilvi P 1] Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland [2] MediCity Research Laboratory, University of Turku, Turku, - - 2014
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising worldwide. We have examined the role of complement components in the progression of cSCC. Analysis of cSCC cell lines (n=8) and normal human epidermal keratinocytes (n=11) with whole transcriptome profiling (SOLiD), quantitative RT-PCR, and western blotting revealed marked overexpression of ...
Zou Xiao-Yan XY Department of Dermatology, Hubei Maternity and Child Health Hospital, Wuhan, - - 2014
Glyoxalase I (GLO1) is a methylglyoxal detoxification enzyme being implicated in the progression of multiple malignancies. However, currently, the role of GLO1 in human nonmelanoma skin tumors remains unclear. To explore the expression of GLO1 in cutaneous neoplasms and its role in the pathogenesis of skin cancers, we determined the ...
Sengupta Aritra A School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, - - 2014
Efficient intracellular delivery of molecules is needed to modulate cellular behavior for laboratory and medical applications, but is often limited by trade-offs between achieving high intracellular delivery and maintaining high cell viability. Here, we studied photoacoustic delivery of molecules into cells by exposing DU145 human prostrate carcinoma cells to nanosecond ...
Lv Xiaoyan X Department of Dermatology, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, - - 2014
Increasingly recognized importance has been assumed for microRNA (miRNA) in the regulation of the delicate balance of gene expression. In our study, we aimed to explore the regulation role of miR181c towards Six2 in metanephric mesenchyme (MM) cells. Bioinformatics analysis, luciferase assay and semi-quantitative real-time (RT) PCR, subsequently RT PCR, ...
Mizunoya Wataru W Department of Bioresource Sciences, Graduate School of Agriculture, Kyushu University, Fukuoka, - - 2014
In this study, we examined the effects of several egg white proteins (ovalbumin, ovomucoid, ovotransferrin and lysozyme) on proliferation and myotube growth in C2C12 murine myoblast cells. Cell proliferation was measured using a water-soluble tetrazolium salt (WST-8)-based assay and then validated using Giemsa staining. Significant proliferative activities of C2C12 cells ...
Khasabov Sergey G SG University of - - 2014
The rostral ventromedial medulla (RVM) projects to the medullary and spinal dorsal horns and is a major source of descending modulation of nociceptive transmission. Traditionally, neurons in the RVM are classified functionally as ON, OFF and NEUTRAL cells based on responses to noxious cutaneous stimulation of the tail or hind ...
Zhang Lianghui L University of Illinois at Chicago, College of Medicine, Chicago, - - 2014
"These results show that a nucleus can promote the formation of a differentiated intestine cell and at the same time contain the genetic information necessary for the formation of all other types of differentiated somatic cell in a normal feeding tadpole. It is concluded that the differentiation of a cell ...
Zeppernick Felix F Departments of *Pathology and Gynecology and Obstetrics #Oncology, Johns Hopkins Medical Institutions, Baltimore, MD ¶The Wistar Institute, Philadelphia, PA †Department of Gynecology and Obstetrics, University Hospital Aachen, Aachen, Germany ‡Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center ∥Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen §Department of Pathology, Hvidovre Hospital, Denmark Gynecologic Clinic, Hvidovre, - - 2014
Serous borderline tumor also known as atypical proliferative serous tumor (APST) is the precursor of ovarian low-grade serous carcinoma (LGSC). In this study, we correlated the morphologic and immunohistochemical phenotypes of 71 APSTs and 18 LGSCs with the mutational status of KRAS and BRAF, the most common molecular genetic changes ...
Prasad Vibhu V Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland Molecular Life Sciences Graduate School, ETH and University of Zurich, - - 2014
Cancer cells are susceptible to oncolytic viruses, albeit variably. Human adenoviruses (HAdVs) are widely used oncolytic agents, engineered to produce progeny within the tumor, and elicit bystander effects. We searched for host factors enhancing bystander effects, and conducted a targeted RNA-interference screen against guanine-nucleotide exchange factors (GEFs) of small GTPases. ...
Hur Yoon-Sun YS Department of Biological Science, Sookmyung Women's University, Seoul, 140-742, - - 2014
Arabidopsis thaliana homeobox 12 (ATHB12), a homeodomain-leucine zipper class I (HD-Zip I) gene, is highly expressed in leaves and stems, and induced by abiotic stresses, but its role in development remains obscure. To understand its function during plant development, we studied the effects of loss and gain of function. Expression ...
Wang Linbo L Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, - - 2014
Fucoxanthin, a natural carotenoid, has been reported to have anti-cancer activity in human colon cancer cells, human prostate cancer cells, human leukemia cells, and human epithelial cervical cancer cells. This study was undertaken to evaluate the molecular mechanisms of fucoxanthin against human bladder cancer T24 cell line. MTT analysis results ...
Khoury Nathalie N Department of Natural Sciences, Lebanese American University, Beirut 1102 2801, - - 2014
Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. Recent studies have focused on the mechanism of action of kefir on cancer cells in vitro. The current study aims at examining the effect of kefir on cell survival, proliferation, and motility of colorectal cancer (CRC) cells. Kefir's ...
Villa Del Campo Cristina C Departamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/ Melchor Fernández Almagro, 3, E-28029 Madrid, - - 2014
Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition ...
Karthaus Wouter R WR Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, - - 2014
The prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murine lineage-tracing experiments show that luminal cells generate basal cells. It has remained challenging to address the molecular details of these transitions and whether ...
Su Kai K CSIRO Manufacturing Flagship, Bayview Avenue, Clayton, VICTORIA 3169, - - 2014
Pelvic organ prolapse is a major hidden burden affecting almost 1 in 4 women. It is treated by reconstructive surgery often augmented with synthetic mesh. To overcome the growing concerns of using current synthetic meshes coupled with the high risk of re-operation, a tissue engineering strategy has been developed, adopting ...
Lee Phil Jun PJ College of Pharmacy, Ajou University, Suwon 443-749, Republic of - - 2014
Heme oxygenase-1 (HO-1) and ATPase inhibitory factor (ATPIF) 1 is often overexpressed in different types of cancer cells. Chrysin is a naturally-occurring flavonoid with antioxidant potentials, but also known to promote apoptosis. We have synthesized four chrysin derivatives and found compounds 1 and 4 remarkably upregulated the expression of HO-1, ...
Dao Pascal - - 2014
A series of triazinic inhibitors of FAK have been recently showed to exert anti-angiogenic activity against HUVEC cells and anti-cancer efficacy against several cancers cell lines. We report herein that we further explored the heterocyclic core of these inhibitors by a fused imidazole ring with the triazine to provide imidazo[1,2-a][1,3,5]triazines. ...
Sarna Michal M Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Mickiewicza 30, Krakow, 30-059, Poland; Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Krakow, 30-387, - - 2014
The relationship between melanin pigmentation and metastatic phenotype of melanoma cells is an intricate issue, which needs to be unambiguously determined to fully understand the process of metastasis of malignant melanoma. Despite significant research efforts undertaken to solve this problem, the outcomes are far from being satisfying. Importantly, none of ...
Chen Liang-Yu LY Gamete Biology - - 2014
Peritubular myoid (PM) cells surround the seminiferous tubule and together with Sertoli cells form the cellular boundary of the spermatogonial stem cell (SSC) niche. However, it remains unclear what role PM cells have in determining the microenvironment in the niche required for maintenance of the ability of SSCs to undergo ...
Ohki Takeshi T Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, - - 2014
We have developed a technique for the endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to an esophageal ulcer following endoscopic submucosal dissection. The epithelial cell sheets successfully prevented esophageal stricture after endoscopic submucosal dissection. Key technology: epithelial cell sheets cultured from oral mucosal tissue and attached proteins ...
Castellarnau M M Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, - - 2014
This study presents stochastic particle barcoding (SPB), a method for tracking cell identity across bioanalytical platforms. In this approach, single cells or small collections of cells are co-encapsulated within an enzymatically-degradable hydrogel block along with a random collection of fluorescent beads, whose number, color, and position encode the identity of ...
Morales-Cruz Moraima - - 2014
BackgroundCytochrome c is an essential mediator of apoptosis when it is released from the mitochondria to the cytoplasm. This process normally takes place in response to DNA damage, but in many cancer cells (i.e., cancer stem cells) it is disabled due to various mechanisms. However, it has been demonstrated that ...
Greene Carol Ann CA Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New - - 2014
We previously reported that neural-crest-derived stromal cells from adult human and rat corneas can differentiate into neuron-like cells when treated with neuronal lineage specifying growth factors. However, it remains unclear whether this level of cell plasticity is unique to the corneal stromal cell population present in the eye. In this ...
Betts-Obregon Brandi S BS Biology, The University of Texas at San Antonio, One UTSA Circle, BSB 1.03.36, San Antonio, TX, 78249, United - - 2014
Purpose:Interphotoreceptor retinoid-binding protein's (IRBP) role in facilitating the exchange of retinoids between rod and cone photoreceptors, retinal pigment epithelium, and Müller cells in the visual cycle remains a mystery. IRBP's ability to bind the pericellular matrix of the cone outer segment and Müller cell villi suggests a function in all-trans ...
Marel Anna-Kristina AK Fakultät für Physik, Ludwig Maximilians Universität, München, Germany; Center for NanoScience, Ludwig Maximilians Universität, München, Germany; Nanosystems Initiative Munich, München, - - 2014
Collective migration of mechanically coupled cell layers is a notable feature of wound healing, embryonic development, and cancer progression. In confluent epithelial sheets, the dynamics have been found to be highly heterogeneous, exhibiting spontaneous formation of swirls, long-range correlations, and glass-like dynamic arrest as a function of cell density. In ...
Tian Xiaohong X Department of Tissue Engineering, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
Telomeres, telomerase and tankyrase (TNKS) have an extremely important and special association with human cell aging and cancer. Telomerase activity is abnormally high in cancer cells and is accompanied by the overexpression of tankyrase 1 (TNKS1). TNKS1 is a positive regulator of telomerase activation and telomere extension in the human body, ...
Lu Guan-Yu GY Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City 114, Taiwan, Republic of China; Department of Pharmacy, Shalu Division, Kuang Tien General Hospital, Taichung 433, Taiwan, Republic of - - 2014
The signaling characteristics of Na(+)/K(+)-ATPase are distinct from its ion pumping activity. Cardiac glycosides modulate the Na(+)/K(+)-ATPase protein complex upon binding, activate downstream signaling pathways and increase [Ca(2+)]i. Recent studies demonstrate that the depletion of p53 and hypoxia-induced factor 1α proteins is caused by cardiac glycosides. However, the detailed mechanisms ...
Hong Woo Young WY New Experimental Therapeutic Branch, National Cancer Center, 111 Jungbalsan-ro, Ilsamdong-gu, Goyang, Gyeonggi-do 410-769, South - - 2014
Here, we propose an integrated multifunctional system constructed by conductive disulfide-biotin-doped polypyrrole nanowires (SS-biotin-Ppy NWs) for capture, release, and in situ quantification of circulating tumor cells (CTCs). A well-ordered three-dimensional nanowire structure equipped with a monoclonal antibody offers a significant impact on the cell-capture efficiency, as well as on electrical- ...
Wu Yuanfeng Y Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, - - 2014
Triclosan is an anti-bacterial agent used in many personal care products, household items, medical devices, and clinical settings. Liver tumors occur in mice exposed to triclosan, a response attributed to peroxisome proliferator-activated receptor alpha (PPARα) activation; however, the effects of triclosan on mouse and human PPARα have not been fully ...
Li Yaqian Y Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, People's Republic of China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, People's Republic of - - 2014
The promise of cell therapy for repair and restoration of damaged tissues or organs relies on administration of large dose of cells whose healing benefits are still limited and sometimes irreproducible due to uncontrollable cell loss and death at lesion sites. Using a large amount of therapeutic cells increases the ...
Wang Wenshan W Institute for Diabetes, Obesity, Metabolism, Department of Cell and Developmental Biology, - - 2014
Brown adipocytes and muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic precursor activity in embryos was confined to ...
Kuhbier Joern W JW Hannover, Germany From the Department of Plastic, Hand and Reconstructive Surgery, Medical School - - 2014
Regarding aesthetics and long-term stability, cell-assisted lipotransfer is a promising method for breast reconstruction. Here, autologous fat grafts enriched with autologous adipose-derived stem cells are transferred. However, as adipose-derived stem cells secrete high amounts of growth factors, potential risks of tumor reactivation remain. In this study, influences of adipose-derived stem ...
Pusateri Allen A From the Department of Pathology and Molecular Biology, Morsani College of Medicine, University of South Florida, Tampa (Dr Margo). Dr Pusateri is a resident in training at the Department of Ophthalmology, Morsani College of Medicine, University of South Florida, - - 2014
Astrocytomas arising within the eye display 2 distinct histologies: one comprises interlacing bundles of spindle-shaped cells mixed with a minority of polygonal cells, and the other consists of large cells with abundant glassy cytoplasm (gemistocytic astrocytes) indistinguishable from cells found in subependymal giant cell astrocytoma. Both histologic patterns express glial ...
Di Stefano Bruno B Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, - - 2014
The induction of cell reprogramming by transcription factors into alternative cell fates opens new avenues for regenerative medicine. Thymic epithelial cells that were obtained from fibroblasts by Foxn1 overexpression support the formation of an ectopic thymus following transplantation.
Palusinska-Szysz Marta M Department of Genetics and Microbiology, Institute of Microbiology and Biotechnology, Maria Curie-Sklodowska University, Akademicka St. 19, 20-033, Lublin, - - 2014
Binding of human apolipoprotein E (apoE) to Legionella pneumophila lipopolysaccharide (LPS) was analysed at the molecular level by Fourier-transform infrared spectroscopy, thereby providing biophysical evidence for apoE-L. pneumophila LPS interaction. Atomic force microscopy imaging of apoE-exposed L. pneumophila cells revealed alterations in the bacterial cell surface topography and nanomechanical properties ...
Rosario C O CO 1] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, - - 2014
Polo family kinase 4 (Plk4) is required for mitotic progression, and is haploinsufficient for tumor suppression and timely hepatocyte polarization in regenerating liver. At the same time, recent evidence suggests that Plk4 expression may have a role in clinical cancer progression, although the mechanisms are not clear. Here we identify ...
Li Lin L 1] School of Ocean, Shandong University, Weihai 264209, China [2] School of Pharmaceutical Sciences, Shandong University, Ji-nan 250012, - - 2014
Aim:Telekin, isolated from the Chinese herb Carpesium divaricatum, has shown anti-proliferation effects against various cancer cells, including hepatocellular carcinoma cells. In this study, we investigated the anti-proliferation mechanisms of telekin in human hepatocellular carcinoma HepG2 cells in vitro.Methods:HepG2 cells were treated with telekin. Cell viability was evaluated using MTT assay. ...
Lee Ji Young JY School of Life Science and Biotechnology, Kyungpook National - - 2014
To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2-methoxyestradiol (2-MeO-E2), 2-MeO-E2-induced cell cycle changes and apoptotic events were compared between human colon carcinoma cell lines HCT116 (p53+/+) and HCT116 (p53-/-). When both cell types were exposed to 2-MeO-E2, a reduction in the cell viability ...
Gómez-Lamarca M Jesús - - 2014
Coordinating exit from the cell cycle with differentiation is critical for proper development and tissue homeostasis. Failure to do so can lead to aberrant organogenesis and tumorigenesis. However, little is known about the developmental signals that regulate the cell cycle exit-to-differentiation switch. Signals downstream of two key developmental pathways, Notch ...
Xiao Ting Ting TT Department of Plant Sciences, Laboratory of Molecular Biology, Wageningen University, Droevendaalsesteeg 1, Wageningen 6708 PB, The - - 2014
Legume root nodules are induced by N-fixing rhizobium bacteria that are hosted in an intracellular manner. These nodules are formed by reprogramming differentiated root cells. The model legume Medicago truncatula forms indeterminate nodules with a meristem at their apex. This organ grows by the activity of the meristem that adds ...
Kasahara Atsuko A Department of Pathology and Immunology, University of Geneva, 1211 Geneva, - - 2014
Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca(2+) homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, ...
Han Seong-Su SS Division of Pediatric Hematology-Oncology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address: - - 2014
Piperlongumine (PL), a pepper plant alkaloid from Piper longum, has anti-inflammatory and anti-cancer properties. PL selectively kills both solid and hematologic cancer cells, but not normal counterparts. Here we evaluated the effect of PL on the proliferation and survival of B-cell acute lymphoblastic leukemia (B-ALL), including glucocorticoid (GC)-resistant B-ALL. Regardless ...
Auernheimer Vera V Department of Physics, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, - - 2014
We investigated the effect of the point mutation E29R on vinculin under cell mechanical aspects. MEFvcl KO cells were transfected with intact eGFP-vinculin (rescue) or mutant E29R vinculin. Cellular stiffness and adhesion strength of mutant E29R vinculin were considerably higher compared to rescue and MEFvcl KO cells. 2D traction microscopy ...
Liu Mingli M Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive Southwest, Atlanta, GA 30310, USA; Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, 720 Westview Drive Southwest, Atlanta, GA 30310, USA. Electronic address: - - 2014
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults with median survival time of 14.6months. A small fraction of cancer stem cells (CSC) initiate and maintain tumors thus driving glioma tumorigenesis and being responsible for resistance to classical chemo- and radio-therapies. It is desirable to ...
Lee Jong Min JM Department of Biological Sciences, College of Biological Science and Biotechnology, Cancer and Metabolism Institute, Konkuk University, Seoul 143-701, Republic of - - 2014
Methoxylated chalcones exert antitumor activities. In the present study, we characterized the cytotoxicity of methylated chalcone derivatives against human colon cancer cells. We synthesized a group of methoxychalcones and explored the molecular mechanisms underlying inhibition of tumor growth by these materials. A new synthetic methoxychalcone, 2'-hydroxy-2,4,6-trimethoxy-5',6'-naphthochalcone (named HMNC-74), most effectively ...
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