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Lin Song S Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, - - 2014
Studies have proved that microRNA-101 (miR-101) functions as a tumor suppressor and is associated with growth and apoptosis of various human cancers. However, the role of miR-101 in osteosarcoma and the possible mechanism by which miR-101 affects the tumor growth and apoptosis have not been fully elucidated. In this study, ...
Huang Jian-Wei JW Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China, - - 2014
Estrogen-related receptor alpha (ERRα) plays an important role in the development of hormone-dependent cancers, but its roles in lung cancer remain elusive. The present study was aimed to investigate the effects of ERRα on the proliferation and metastasis of lung cancer A549 cells. The mRNA and protein levels of ERRα ...
Saxena Aditya A Department of Zoology, University of Cambridge, Cambridge, United - - 2014
Most epithelial tubes arise as small buds and elongate by regulated morphogenetic processes including oriented cell division, cell rearrangements, and changes in cell shape. Through live analysis of Drosophila renal tubule morphogenesis we show that tissue elongation results from polarised cell intercalations around the tubule circumference, producing convergent-extension tissue movements. ...
Dong Chenbo C Department of Chemical Engineering, West Virginia University, Morgantown WV, 26506, - - 2014
Toxicity of engineered nanomaterials is associated with their inherent properties, both physical and chemical. Recent studies have shown that exposure to multi-walled carbon nanotubes (MWCNTs) promotes tumors and tumor-associated pathologies and lead to carcinogenesis in model in vivo systems. Here in we examined the potential of purified MWCNTs used at ...
Kanthilal Manisha M Center for Biomedical Engineering, Brown University, Providence, RI 02912 ; Department of Molecular Pharmacology, Physiology, & Biotechnology, Brown University, Providence, RI - - 2014
The stromal vascular fraction (SVF) of human adipose tissue is a heterogeneous population, with component cell types that may or may not contribute to its regenerative potential. Recent findings indicate that single-cell mechanical biomarkers are characteristic of cell type and can be used comparably to gene and protein expressions to ...
Zhamanbaeva G T GT Department of Biophysics and Biomedicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan, - - 2014
We studied the effects of ethanol extract from Hippophae rhamnoides L. leaves on the growth and differentiation of human acute myeloid leukemia cells (KG-1a, HL60, and U937). The extract of Hippophae rhamnoides L. leaves inhibited cell growth depending on the cell strain and extract dose. In a high concentration (100 ...
Zhou Baosheng B Department of Neurosurgery, The First Central Hospital of Tianjin, 56 Fukang Road, Tianjin, 300192, - - 2015
Cell division cycle 2 (CDC2) is always overexpressed in malignant tumor cells and is correlated with chemosensitivity, but it is unclear whether CDC2 overexpression contributes to the chemoresistance potential of glioma cells. The aim of study was to determine the relationship of CDC2 expression with the prognosis and chemoresistance of ...
Niesen Judith J Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 52074, Aachen, - - 2014
Rhabdomyosarcoma (RMS) is a rare and aggressive soft tissue sarcoma with limited treatment options and a high failure rate during standard therapy. New therapeutic strategies based on targeted immunotherapy are therefore much in demand. The epidermal growth factor receptor (EGFR) has all the characteristics of an ideal target. It is ...
Sun Ting T Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, China, - - 2014
We have previously demonstrated that novel 1-alkyl-tryptophan analogs 1-butyltryptophan (1-BT) can serve as a potential antitumor agent. However, the molecular mechanisms of 1-BT on cancer cells remain to be elucidated. The effect of 1-BT on cell proliferation was detected by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and clone formation assay ...
Guo Lihua - - 2014
BackgroundIncreasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in gastric cancer (GC). In this study, we aimed to investigate the expression of miR-133b in a large number of GC samples and elucidate its role in GC carcinogenesis and the detailed mechanism.MethodsWe used Taqman probe stem-loop ...
Mahajan Anand A AA Sinhgad Institute of Pharmacy, Narhe, Pune - 411041, affiliated to University of Pune, India. - - 2014
In search of novel cytotoxic agents based on acridone scaffold, twenty five derivatives of acridone-2-carboxamide were synthesized and evaluated against a panel of eleven cancer cell lines by using MTT assay. Amides, A5 and A8 (IC50 = 0.3 μM) exhibited good cytotoxicity against MCF7. Compound A22 (IC50 = 4.3 μM) ...
Yang Tian T Department of Respiratory Medicine, The First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, - - 2014
The current study aims to investigate the fuctional role of miRNA-25 in non-small cell lung cancer (NSCLC) cells. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-25 in NSCLC cell lines and 11 pairs of human NSCLC and non-cancerous tissues. The inhibitor of miR-25 was ...
Wissing Marie - - 2014
BackgroundCorona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Polycystic ovary syndrome (PCOS) is a common cause of infertility. It is controversial whether PCOS ...
Chen Jiang-Wei JW Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, - - 2014
Nucleus pulposus (NP) cells reside in a hypoxic environment in vivo, while the mechanisms of how NP cells maintain survival under hypoxia are not clear. Autophagy is an important physiological response to hypoxia and implicated in the survival regulation in most types of cells. This study was designed to investigate ...
Bruhn Christopher C Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI), 07745 Jena, - - 2014
Cell cycle progression is coordinated with metabolism, signaling and other complex cellular functions. The investigation of cellular processes in a cell cycle stage-dependent manner is often the subject of modern molecular and cell biological research. Cell cycle synchronization and immunostaining of cell cycle markers facilitate such analysis, but are limited ...
Saeed Aram A School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, - - 2014
A dual thermoresponsive and magnetic colloidal gel matrix is described for enhanced stem-cell culture. The combined properties of the material allow enzyme-free passaging and expansion of mesenchymal stem cells, as well as isolation of cells postculture by the simple process of lowering the temperature and applying an external magnetic field. ...
Eytan Danielle F DF Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, U.S.A; NIH Medical Research Scholars Program, National Institutes of Health, Bethesda, Maryland, U.S.A; Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, - - 2014
Head and neck squamous cell carcinoma (HNSCC) cells are resistant to cell death induced by tumor necrosis factor ligands such as tumor necrosis factor α (TNFα) or TNF-related apoptosis-inducing ligand (TRAIL) and cytotoxic chemotherapies. Recently, genetic alterations in cell death pathways, including inhibitor of apoptosis proteins, have been demonstrated in ...
Du Xuewen - - 2014
As an important and necessary step of sampling biological speci-mens, the separation of malignant cells from a mixed population of cells usually requires sophisticated instruments and/or expensive reagents. For the health care in developing regions, there is a need of inexpensive sampling method to capture tumor cells for rapid and ...
Ju Sung-Min SM Department of Pathology, College of Korean Medicine, Wonkwang University , Iksan, Jeonbuk , Republic of Korea - - 2014
Abstract Context: Nardostachys chinensis Batalin (Valerianaceae) has been used in Korean traditional medicine to elicit stomachic and sedative effects. However, the anti-leukemic activities of N. chinensis have not been well examined. Objective: To investigate the effect of N. chinensis on differentiation and proliferation in the human promyelocytic leukemic HL-60 cells. ...
Govindasamy Niraimathi N Institute for Stem Cell Biology and Regenerative Medicine (inStem), National Centre for Biological Sciences, GKVK Campus, Bellary Road, Bangalore 560065, - - 2014
Adult stem cells face the challenge of maintaining tissue homeostasis by self-renewal while maintaining their proliferation potential over the lifetime of an organism. Continuous proliferation can cause genotoxic/metabolic stress that can compromise the genomic integrity of stem cells. To prevent stem cell exhaustion, highly proliferative adult tissues maintain a pool ...
Huang Jing J Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information Engineering, Shanghai University, Shanghai, PR - - 2014
Raman spectroscopy has been widely used in biomedical research and clinical diagnostics. It possesses great potentials for the analysis of biochemical processes in cell studies. In this article, the surface-enhanced Raman spectroscopy (SERS) of normal and cancerous liver cells incubated with SERS active substrates (gold nanoparticle) was measured using confocal ...
Dardelle Flavien F Laboratoire de Glycobiologie et Matrice Extracellulaire Végétale (Glyco-MEV), EA 4358, Normandy University, IRIB, VASI, 76821 Mont-Saint-Aignan Cedex, France, COBRA, UMR6014 and FR3038, Normandy University, INSA Rouen, CNRS, IRCOF, 76821 Mont-Saint-Aignan Cedex, France, Laboratoire Polymères, Biopolymères, Surfaces, UMR CNRS 6270, Normandy University, 76821 Mont-Saint-Aignan Cedex, France and Génétique et Amélioration des Fruits et Légumes, INRA UR1052, 84143 Montfavet Cedex, - - 2014
In flowering plants, fertilization relies on the delivery of the sperm cells carried by the pollen tube to the ovule. During the tip growth of the pollen tube, proper assembly of the cell wall polymers is required to maintain the mechanical properties of the cell wall. Xyloglucan (XyG) is a ...
Cutler Roy G RG Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, - - 2014
Sphingolipids are a highly conserved lipid component of cell membranes involved in the formation of lipid raft domains that house many of the receptors and cell-to-cell signaling factors involved in regulating cell division, maturation, and terminal differentiation. By measuring and manipulating sphingolipid metabolism using pharmacological and genetic tools in Caenorhabditis ...
Hevir-Kene Neli N Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, - - 2014
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or formation of DNA-damaging species. To characterize model cell lines of endometrial cancer, we determined the expression profiles of the estrogen receptors (ERs) ESR1, ESR2 and GPER, and 23 estrogen ...
Jain Aditi A Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida 201307, Uttar Pradesh, - - 2014
Heart is an organ which is under a constant work load that generates numerous stress responses. Heart failure is associated with increased plasma norepinephrine (NE) and hypertrophic cell death. Within the current study we try to understand the concentration dependent molecular switch from hypertrophy to apoptosis under stress. The effect ...
Wang Shoufeng S Department of Thoracic Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. - - 2014
This study aimed to evaluate the biological functions of excision repair cross complementation goup 1 (ERCC1) in cell proliferation, cell cycle, invasion and cisplatin response of non-small cell lung cancer (NSCLC) cells. Firstly, ERCC1 gene was successfully transfected into H1299 cells by gene cloning and transfection techniques. Then, cell proliferation ...
Miyatake Yukiko Y Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan; Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland. Electronic address: - - 2014
Adult T-cell leukemia/lymphoma (ATL) is an intractable T-cell malignancy accompanied by massive invasion of lymphoma cells into various tissues. We demonstrate here that ATL cells cultured on a layer of epithelial-like feeder cells form anchorage-dependent multicellular aggregates (Ad-MCAs) and that a fraction of MCA-forming ATL cells acquire CD44 high cancer ...
Kapodistria Katerina K Institute of Biosciences and Applications, National Centre for Scientific Research, N.C.S.R. "Demokritos", Terma Patriarchou Grigoriou & Neapoleos,15310 Agia Paraskevi, Attiki, - - 2014
Nephrin, a cell surface signaling receptor, regulates podocyte function in health and disease. We study the role of nephrin in β-cell survival signaling. We report that in mouse islet β-cells and the mouse pancreatic beta-cell line (βTC-6 cells) nephrin is associated and partly co-localized with PI3-kinase. Incubation of cells with ...
Tanabe Tsuyoshi - - 2014
Secretory phospholipases A2 (sPLA2) initiate the biosynthesis of eicosanoids, they are increased in the airway of persons with severe asthma, and they induce mucin hypersecretion. We used IL-13 transformed highly enriched goblet cells and differentiated (ciliary cell enriched) human bronchial epithelial (HBE) cell culture to evaluate the relative contribution of ...
Chen Huaxia H , Jinan, - - 2015
The aim of this study was to investigate the role of RUNX3 in esophageal squamous cell carcinoma (ESCC) cells biological behavior and the relationship between the expression of RUNX3 and MMP-9, TIMP-1, ICAM-1. RUNX3 levels in 90 esophageal squamous cell carcinoma specimens using immunohistochemical staining to examine the correlation between ...
Flores Sebastian E SE Department of Surgery, University of Otago Christchurch, PO Box 4345, Christchurch, New - - 2014
Despite the evidence suggesting a role for Helicobacter pylori in the induction of systemic iron deficiency anaemia, little is known about the possibility of infection-associated changes in cellular iron homeostasis at the gastric epithelium. In this study we compared four different techniques for measuring iron in AGS cells, a gastric ...
Chen Pei-Yi PY Center of Medical Genetics, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan. - - 2014
Fisetin (3,7,3',4'-tetrahydroxyflavone), a flavonol compound of flavonoids, exhibits a broad spectrum of biological activities including anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective effects. The aim of this study is to investigate the cytoprotective effect of fisetin and the underlying molecular mechanism against hypoxia-induced cell death in PC12 cells. The results of this ...
Zhang Wei W Department of Orthopaedic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China, - - 2014
Beclin-1, a well-known key regulator of autophagy, has been implicated in many disorders, including cancer, aging, and degenerative diseases. Previous studies demonstrated that Beclin-1 participated in tumorgenesis and was highly expressed in colorectal cancer cells, primary duodenal adenocarcinoma, and hepatocellular carcinoma cells, and overexpression of Beclin-1 could induce autophagic cell ...
Xing Li-Li LL Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, - - 2014
Neuroblastoma is an embryonic neoplasm originating from the neural crest with cellular heterogeneity as one of its oncobiological characteristics. This study was undertaken to determine whether human neuroblastoma contains stem cell-like cells. Twenty patients with neuroblastoma who have been treated in our hospital since January 2005 were divided into pre-operative ...
Lin Xu-Yong XY Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, - - 2014
High expression of carbonic anhydrase IX (CA IX) has been reported in clear cell renal cell carcinoma (ccRCC); few studies have reported CA IX expression in other tumours with predominantly clear cell morphology. The aim of study was to examine the expression and diagnostic implications of CA IX in these ...
Jurczyk Matthew M Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Chicago, - - 2014
Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of ...
Lee Jeong-Won JW Departments of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, - - 2014
Sphingosine kinase 1 (SK1) is over-expressed in multiple types of human cancer. SK1 has growth-promoting effects and has been proposed as a potential therapeutic target. We investigated the therapeutic effects of SK1 inhibition in epithelial ovarian carcinoma (EOC). SK1 siRNA or inhibitors were tested in EOC cell lines, including A2780, ...
Norouzy Amir A Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen - - 2014
The macrocycle p-sulfonatocalix[4]arene (CX4) and the fluorescent dye lucigenin (LCG) form a stable host-guest complex, in which the dye fluorescence is quenched. Incubation of live V79 and CHO cells with the CX4/LCG chemosensing ensemble resulted in its spontaneous uptake. Subsequent addition of choline, acetylcholine, or protamine, which have a high ...
Xu Hongxia H Department of Nutrition, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400038, China. - - 2014
Platycodin D (PD), a major saponin derived from Platycodin grandiflorum, exerted cytotoxicity against prostate cancer cell lines (PC3, DU145 and LNCaP cells) with IC50 values in the range of 11.16 to 26.13μmol/L, whereas RWPE-1cells (a non-malignant human prostate epithelial cell line) were not significantly affected. A further study in these ...
Han Xiao-Jian XJ Institute of Translational Medicine, Nanchang University, Nanchang, P.R. - - 2014
Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial fission and migration in metastatic MDA-MB‑231 cells, but not in non-metastatic MCF-7 cells. Inhibition of Drp1-dependent mitochondrial fission by Mdivi-1 or silencing Drp1 attenuated hypoxia-induced mitochondrial fission and migration in MDA-MB‑231 cells. ...
Zhang Kailiang K Department of Neurosurgery, Tianjin Medical University General Hospital; Laboratory of Neuro-Oncology, Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Chinese Glioma Cooperative Group (CGCG), 6 Tiantanxi Li, Beijing 100050, - - 2014
Inhibitor of β-catenin and T-cell factor (ICAT) is a key component of Wnt/β-catenin signaling. ICAT blocks the formation of the β-catenin/TCF complex and has been demonstrated to be involved in embryonic development and carcinogenesis. As an inhibitor of canonical Wnt signaling, ICAT was presumed to be a tumor-suppressor gene. However, ...
Lee Ra Ham RH Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju 651-756, Republic of - - 2014
7,8-Dihydroxyflavone (7,8-DHF) is a member of the flavonoid family and has recently been identified as a brain-derived neurotrophic factor mimetic that selectively activates tropomyosin-receptor kinase B with high affinity. The antioxidant and anticancer effects of 7,8-DHF have been reported. However, the pharmacological mechanisms of 7,8-DHF in oral cancer are unclear. ...
Nagura Michikazu M Department of Gynecology and Obstetrics, Kyoto University Graduate School of - - 2014
Local invasion is a common pattern of spread in uterine cervical squamous cell carcinoma (CSCC). Although transforming growth factor-beta (TGF-β) facilitates invasion of various types of cancer cells, the role of the TGF-β pathway in CSCC is unclear. In this study, we analyzed the role of TGF-β signaling in the ...
Medina-Reyes Estefany I EI Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, CP 54059, Estado de México, - - 2014
Titanium dioxide has been classified in the 2B group as a possible human carcinogen by the International Agency for Research on Cancer, and amid concerns of its exposure, cell cycle alterations are an important one. However, several studies show inconclusive effects, mainly because it is difficult to compare cell cycle ...
Jia Jian-Wei JW Department of Oncology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, - - 2014
The targeted delivery of small interfering RNA (siRNA) to specific tumor tissues and tumor cells remains as one of the key challenges in the development of RNA interference as a therapeutic application. The ribosome assembly factor NIN/RPN12 binding protein (NOB1) has been suggested to be essential for processing of the ...
Moirangthem Dinesh Singh DS a Institute of Bioresources and Sustainable Development, Takyelpat Institutional Area , Imphal 795001 , Manipur , - - 2014
This study was conducted to determine the effect of Cephalotaxus griffithii needle essential oil (CGNO) on proliferation and migration of human cervical cancer (HCC) cells. CGNO treatment decreased the viability of all the tested HCC (HeLa, ME-180 and SiHa) cells. Morphological and DNA fragmentation analysis of CGNO-treated HeLa cells indicated ...
Shadi Somayeh S a Department of Biology, Faculty of Science , University of Isfahan , Isfahan , Islamic Republic of - - 2014
Acetone:chloroform (1:2) extract of the aerial parts of Euphorbia connata Boiss. (Euphorbiaceae) was investigated for its diterpenoids. This led to the isolation of one known and two new diterpenes, belonging to the pentahydroxy-13(17)-epoxy-8,10(18)-myrsinadiene and tetrahydroxy-5,6-epoxy-14-oxo-jatropha-11(E)-ene classes. The structures were elucidated based on (13)C and (1)H NMR as well as 2D ...
Liu Ruihan R Department of Obstetrics and Gynecology, Qilu Hospital of Shangdong University, No. 107 Wen Hua Xi Road, Jinan, 250012, Shandong, - - 2014
The purpose of our study was to investigate the therapeutic potential of Celecoxib for epithelial ovarian cancer, especially on cellular morphological changes, proliferation invasion and epithelial-mesenchymal transition (EMT). The MTT and transwell assays were performed to evaluate the effect of Celecoxib on proliferation and invasion ability of ovarian cancer cell ...
Ji Jiang J Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, - - 2014
Keloids are one of the common refractory conditions in dermatology and aesthetic plastic surgery. The most effective treatment is superficial radiotherapy followed by surgical removal. The rate of recurrence is strongly associated with the total dose of ionizing irradiation, and the underlying mechanism remains unclear. In this study, we used ...
Hawkins Kate K Kate Hawkins, Shona Joy, Tristan McKay, Molecular Cell Sciences, St George's University of London, London SW17 0RE, United - - 2014
Induced pluripotent stem (iPS) cells, somatic cells reprogrammed to the pluripotent state by forced expression of defined factors, represent a uniquely valuable resource for research and regenerative medicine. However, this methodology remains inefficient due to incomplete mechanistic understanding of the reprogramming process. In recent years, various groups have endeavoured to ...
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