Search Results
Results 101 - 150 of 2180
1 2 3 4 5 6 7 8 9 10 >
Wu Jinfeng J Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. - - 2014
Icariside II (IS) is a metabolite of icariin, which is derived from Herba Epimedii. In the present study, the antiproliferative effects of IS on A375 human melanoma cells were examined in vitro and a possible mechanism through the ROS‑p38‑p53 pathway is discussed. A cell WST‑8 assay revealed that treatment with ...
Busch Maike M Department of Neuroanatomy, Medical Faculty, Institute of Anatomy, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, - - 2014
Retinoblastoma (RB) is the most common malignant intraocular childhood tumor. Forty years after their first description, in the present study, we re-characterized seven established retinoblastoma cell lines with regard to their RB1 mutation status, morphology, growth pattern, endogenous apoptosis levels, colony formation efficiency in soft agar and invasiveness and dissemination ...
Bannunah Azzah M - - 2014
This study investigated the effect of nanoparticle size and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial transport. Initially, toxicity assays showed that cell viability and cell membrane integrity were dependent on the surface ...
Orzechowska Emilia Joanna - - 2014
Low cellular level of BID is critical for viability of numerous cancer cells. Sensitization of cells to anticancer agents by BID overexpression from adenovirus or pcDNA vectors is a proposed strategy for cancer therapy; however it does not provide any stringent control of cellular level of BID. The aim of ...
Feng Liang L Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 148 Baojian Road, Nangang District, Harbin, 150086, - - 2014
Ser/Thr protein phosphatase 5 (PPP5C) has been reported to participate in tumor progression. However, its functional role in hepatocellular carcinoma (HCC) remains unknown yet. In this study, we firstly evaluated the expression levels of PPP5C in six HCC cell lines by real-time PCR and found that PPP5C was widely expressed ...
Tsang Matthew M Departments of Dentistry and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Bldg., London, ON, N6A 5C1, - - 2014
Connective tissue growth factor (CTGF/CCN2), a member of the CCN family of matricellular proteins is upregulated in both fibrosis as well as tissue repair. Recently, we showed that, in mice, CCN2 expression by fibroblasts was required for dermal fibrogenesis, but not for cutaneous tissue repair. Lineage tracing analysis linked the ...
Bai Haihua H Department of Chemistry and Institute for Nano-Chemistry, Jinan University, Guangzhou, - - 2014
Apigenin is a flavonoid, which has been proved to possess effective anti-cancer bioactivities against variety of cell lines. However, little is known about its effect on the cell-surface and the interaction between cell-surface and the reacting drug. In this study, human breast cancer line (MCF-7) was selected to be as ...
Stachowiak Radosław R Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland, - - 2014
Internalins comprise a class of Listeria monocytogenes proteins responsible for activation of signalling pathways leading to phagocytic uptake of the bacterium by the host cell. In this paper, a possible role of Lmo0171-a new member of the internalin family was investigated. Disruption of the lmo0171 gene resulted in important cell ...
Thimmegowda N R NR World Class Institute (WCI), Korea Research Institute of Bioscience and Biotechnology (KRIBB), 363-883, Republic of Korea; Department of chemistry, Govt.S K S J T Institute, 560001, Bangalore, Karnataka, - - 2014
In the present study we have synthesized novel water soluble derivatives of natural compound aloe emodin 4(a-j) by coupling with various amino acid esters and substituted aromatic amines, in an attempt to improve the anticancer activity and to explore the structure-activity relationships. The structures of the compounds were determined by ...
Gnanasegaran Nareshwaran N cGMP-Compliant Stem Cell Laboratory, Hygieia Innovation Sdn. Bhd, Lot 1G-2G, Lanai Complex No. 2, Persiaran Seri Perdana, Precinct 10, 62250, Federal Territory of Putrajaya, - - 2014
Among the debilitating diseases, neurological related diseases are the most challenging ones to be treated using cell replacement therapies. Recently, dental pulp stem cells (SHED) were found to be most suitable cell choice for neurological related diseases as evidenced with many preclinical studies. To enhance the neurological potential of SHED, ...
Gwozdzinska Paulina P Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90363 Lodz, Poland. - - 2014
Conjugated phenylenevinylene oligoelectrolytes, which consist of a phenylenevinylene core equipped at each end with hydrophilic pendent groups, are shown to be good candidates for mammalian cell membrane staining. When used in the micromolar concentration range, they express low to moderate cell toxicity for selected regular and cancerous cell lines as ...
Hori Hideo H Faculty of Clinical Engineering, School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, - - 2014
Scaffolds, growth factors, and cells are three essential components in regenerative medicine. Nonwoven filters, which capture cells, provide a scaffold that localizes and concentrates cells near injured tissues. Further, the cells captured on the filters are expected to serve as a local supply of growth factors. In this study, we ...
Wang Jing - - 2014
Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with small molecule inhibitors, particularly with GANT-61, significantly suppresses NB growth. However, NB with MYCN amplification is less sensitive to GANT-61 than those without ...
Santos Mariana M Neuroscience Laboratory, Health Sciences Department, Centre for Cell Biology, University of Aveiro, 3810-193, Aveiro, - - 2014
Cell division in eukaryotes requires the disassembly of the nuclear envelope (NE) at the beginning of mitosis and its reassembly at the end of mitosis. These processes are complex and involve coordinated steps where NE proteins have a crucial role. Lamina-associated polypeptide 1 (LAP1) is an inner nuclear membrane protein ...
Zamaraev Alexey V AV Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, - - 2014
Programmed cell death plays a central role in the regulation of homeostasis and development of multicellular organisms. Deregulation of programmed cell death is connected to a number of disorders, including cancer and autoimmune diseases. Initiation of cell death occurs in the multiprotein complexes or high molecular weight platforms. Composition, structure, ...
Ma Yanxin Y Department of Nuclear Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. - - 2014
MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non‑small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR‑106a in NSCLC-cell resistance to DDP and its precise molecular mechanism has remained ...
Yang Shaobo S Department of Surgery, Children's Hospital, Fudan University, Shanghai 201102, P.R. - - 2014
SOX2 is a transcription factor associated with the pluripotency, proliferative potential, and self-renewing properties observed with embryonic stem cells and germ cells. SOX2 expression has been reported in several cancers and is implicated in tumorigenesis. We previously found that SOX2 expression was correlated to the clinical stage of neuroblastoma. Recently, ...
Chaudhary P P Department of Molecular and Medical Genetics, Texas Center for Health Disparities and the Institute for Cancer Research, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, - - 2014
Background:Annexin A2 (AnxA2), a calcium-dependent phospholipid binding protein, is abundantly present at the surface of triple-negative and Herceptin-resistant breast cancer cells. Interactions between cell-surface AnxA2 and tyrosine kinase receptors have an important role in the tumour microenvironment and act together to enhance tumour growth. The mechanism supporting this role is ...
Zuo J J Department of Stomatology, Xiangya Hospital, Central South University, Changsha, 410008, - - 2014
A variety of inflammatory cytokines have been demonstrated to participate in tumorigenesis and progression. Secretory leukocyte protease inhibitor (SLPI) has been demonstrated to show a broad-spectrum of anti-inflammatory effects. This study investigates the expression of SLPI in human pancreatic cancer tissues and cells as well as its biological effects in ...
Lau Sean K SK Department of Pathology, Southern California Permanente Medical Group, Kaiser Permanente Orange County-Anaheim Medical Center, 3440 East La Palma Avenue, Anaheim, CA, 92806, USA, - - 2014
Spindle cell lipoma is a histologically distinct variant of lipoma characteristically arising in the subcutis of the posterior neck, upper back, or shoulder. Spindle cell lipomas infrequently occur within the oral cavity and, in particular, rarely involve the tongue. The clinical and pathologic features of eight cases of spindle cell ...
Shimizu Tatsuya T Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical - - 2014
In addition to stem cell biology, tissue engineering is an essential research field for regenerative medicine. In contrast to cell injection, bioengineered tissue transplantation minimizes cell loss and has the potential to repair tissue defects. A popular approach is scaffold-based tissue engineering, which utilizes a biodegradable polymer scaffold for seeding ...
Teimoori-Toolabi Ladan L aDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine bBiosensor Research Center, Endocrinology and Metabolism Cellular and Molecular Science Institute, Tehran University of Medical Sciences cMolecular Medicine Department, Biotechnology Research Center dVirology Department, Pasteur Institute of Iran, Tehran, - - 2014
Colon cancer is the second to third common cancer worldwide. Several efforts have been made to reveal the pathways responsible for drug resistance in this type of cancer. We aimed to investigate the effect of silencing both mutant and wild-type Kristen Rous sarcoma (k-ras) on the response of human colorectal ...
Bao Lingjie L Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. - - 2014
Cisplatin resistance is a major challenge in the clinical treatment of ovarian cancer, of which the underlying mechanisms remain unknown. The aim of the present study was to explore the role of autophagy in cisplatin resistance in ovarian cancer cells. A2780cp cisplatin‑resistant ovarian carcinoma cells and the A2780 parental cell ...
Zhao Rui R Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA - - 2014
Rapid progression through the cell cycle and a very short G1 phase are defining characteristics of embryonic stem cells. This distinct cell cycle is driven by a positive feedback loop involving Rb inactivation and reduced oscillations of cyclins and cyclin-dependent kinase (Cdk) activity. In this setting, we inquired how ES ...
Emery Edward C EC Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambirdge, CB2 - - 2014
Stimulus-coupled incretin secretion from enteroendocrine cells plays a fundamental role in glucose homeostasis, and could be targeted for the treatment of type-2 diabetes. Here, we investigated the expression and function of transient receptor potential (TRP) ion channels in enteroendocrine L-cells producing glucagon-like peptide-1 (GLP-1). By microarray and qPCR analysis we ...
Xu Yunhua Y Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, P.R. - - 2014
The mitochondrial genome DNA copy number is critical for the functional maintenance of the mitochondria and energy acquisition for cell metabolism. Epithelial to mesenchymal transition (EMT) is an important process during embryonic development and has also been hypothesized to exhibit a significant role in cancer cell invasion and metastasis. In ...
Aioub Mena M Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive, Atlanta, Georgia 30332-0400, United - - 2014
Recently, we utilized the optical properties of gold nanoparticles (AuNPs) for plasmonically enhanced Rayleigh scattering imaging spectroscopy (PERSIS), a new technique that enabled the direct observation of AuNP localization. In this study, we employ PERSIS by using AuNPs as light-scattering probes to compare the relative efficacy of three chemotherapeutic drugs ...
Liu Dan D Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, 100084 Beijing, - - 2014
The germinal centre (GC) reaction supports affinity-based B-cell competition and generates high-affinity bone-marrow plasma cells (BMPCs). How follicular T-helper (TFH) cells regulate GC selection is not clear. Using competitive mixed chimaera, we show here that, beyond the role in promoting TFH development, ICOSL (inducible T-cell co-stimulator ligand, also known as ...
van Eyk Armorel Diane AD Division of Pharmacology, Department of Pharmacy and Pharmacology, University of the Witwatersrand , Parktown , South - - 2014
Abstract Context: Artificial sweeteners (AS) have been associated with tumor development (including colon cancer) in both animals and humans although evidence has been conflicting. Objectives: Additional research was thus conducted by studying the effects of 5 AS on the morphology, cell proliferation and DNA in cells by utilizing Caco-2, HT-29 ...
Furusawa Yukihiro Y Department of Biochemistry, Graduate School of Pharmaceutical Science, Keio University, Tokyo, 105-8512, - - 2014
Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous bacteria (SFB) facilitate the development of TH17 ...
Lee Chu-I CI Department of Medical Laboratory Science and Biotechnology, Fooyin University, 151 Jinxue Rd., Daliao Dist., Kaohsiung 83102, Taiwan, Republic of - - 2014
Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-d-glucan, three major effective components in A. camphorata extracts (ACE). ACE exhibited a selective cytotoxic effect on BxPC-3 human pancreatic cancer cells. ACE markedly inhibited the migration ability of ...
Jiang Qinglong Q Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, USA. - - 2014
Different lengths of rutile TiO2 nanowires (NW) with wide-open space for effective material filling were used as photoanodes for perovskite solar cells. Cells with 900 nm nanowires as photoanodes exhibit a current density of 22 mA cm(-2) and an efficiency of 11.7%, outperforming the reported TiO2 nanowire-based perovskite solar cells.
Fogli Laura K - - 2014
ABSTRACT Mantle cell lymphoma (MCL) is a rare B-cell malignancy that carries a relatively poor prognosis compared to other forms of non-Hodgkin's lymphoma. Standardized preclinical tools are desperately required to hasten the discovery and translation of promising new treatments for MCL. Through an initiative organized through the Mantle Cell Lymphoma ...
Vogt Niklas - - 2014
Abstract Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14)(q13;q32) leading to an overexpression of cyclin D1, a mediator of G1-S-phase transition. Thus MCL is regarded as a paradigm of lymphoma with a dysregulated cell cycle. The proliferation rate of MCL is in fact a strong predictor of outcome. ...
Groppelli Elisabetta E Division of Infection and Immunity, University College London, London, United - - 2014
Rapid HIV-1 spread between CD4 T lymphocytes occurs at retrovirus-induced immune cell contacts called virological synapses (VS). VS are associated with striking T cell polarization and localized virus budding at the site of contact that facilitates cell-cell spread. In addition to this, spatial clustering of organelles including mitochondria to the ...
Knight Laura M LM School of Molecular and Cellular - - 2014
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity of recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV Small and Large Tumour (ST and LT) antigens. Although a number of molecular ...
Umezu Tomohiro T Department of Molecular Science, Tokyo Medical University, Tokyo, Japan; - - 2014
Exosomes are small endosome-derived vesicles containing a wide range of functional proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the microenvironment. In multiple myeloma (MM), the massive proliferation of malignant plasma cells causes hypoxia. To date, the majority of in vitro hypoxia studies of cancer cells have ...
Zovko Ana A Dep. Oncology/patology, Karolinska - - 2014
Marine derived compounds have been explored and considered as possible antitumor agents. In this study we analyzed extracts of the sponge Cribrochalina vasculum for their ability to inhibit tumor cell proliferation. Screening identified two acetylenic compounds of similar structure that showed strong tumor specific toxicity in non small cell lung ...
Hwang C C CC Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, - - 2014
Reovirus is a potent oncolytic virus in many human neoplasms that has reached phase II and III clinical trials. Our laboratory has previously reported the oncolytic effects of reovirus in canine mast cell tumour (MCT). In order to further explore the potential of reovirus in veterinary oncology, we tested the ...
Bir Aritri A Department of Biochemistry, Institute of Post Graduate Medical Education and Research, 244B A. J. C. Bose Road, Kolkata, 700020, - - 2014
This study has shown that purified recombinant human α-synuclein (20 μM) causes membrane depolarisation and loss of phosphorylation capacity of isolated purified rat brain mitochondria by activating permeability transition pore complex. In intact SHSY5Y cells, lactacystin (5 μM), a proteasomal inhibitor, causes an accumulation of α-synuclein with concomitant mitochondrial dysfunction ...
Gao Huiping H State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital,Shanghai Jiaotong University School of - - 2014
Purpose:The aim of our study is to elucidate whether T cells expressing GPC3-targeted chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their potential in the treatment of HCC. Experimental Design:T cells expressing a first generation and third generation GPC3-targeted CAR were prepared using lentiviral vector transduction. The ...
Robitaille Christina N CN INRS-Institut Armand-Frappier, Université du Québec, 531 boulevard des Prairies, Laval, QC, H7V 1B7, - - 2014
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic proprieties by determining their effects on proliferation, prostatic specific antigen (PSA) secretion and androgen receptor (AR) expression and AR phosphorylation in androgen-dependent LNCaP human prostate cancer cells, as well as on the expression and ...
Liu Aifeng A Cancer Research Institute University of South China, Hengyang, Hunan 421001, P.R. - - 2014
Nasopharyngeal carcinoma (NPC) has a highly increased incidence rate (20/100,000) in Southern regions of China, while being rare in the rest of the world. NPC is a malignant type of cancer due to its high occurrence rate of metastasis; however, biomarkers for effective diagnosis and treatment are yet to be ...
Zhao Pengjun P Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310002, P.R. - - 2014
Rhizoma paridis is widely used for cancer therapy due to its potential involvement in the suppression of tumor growth. However, at present there is no clear explanation for the mechanism underlying the inhibitory effects of Rhizoma paridis combined with hyperthermia on tumor growth. The aim of the present study was ...
Liu Songyang S Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. - - 2014
A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein associated with metastasis in a number of types of cancer. Little is known, however, regarding the role of ADAM10 in hepatocellular carcinoma (HCC). The aim of the present study was to evaluate whether downregulation of ADAM10 effects HCC cell proliferation, cell ...
Yamada Tomohiro T Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan, - - 2014
The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell ...
Zhao Qinfu - - 2014
A redox-responsive delivery system based on colloidal mesoporous silica (CMS) has been developed, in which 6-mercaptopurine (6-MP) was conjugated to vehicles by cleavable disulfide bonds. The oligosaccharide of hyaluronic acid (oHA) was modified on the surface of CMS by disulfide bonds as a targeting ligand and was able to increase ...
Liu Tong - - 2014
NiO-YSZ hollow fiber anode support with different microstructures has been prepared using a phase-inversion method. The effect of the solid loading of the phase-inversion suspensions on the microstructure development of the NiO-YSZ anode support has been investigated. Solid loading in the suspension has been found to have an important influence ...
Fan Bo-Yi BY State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of - - 2014
Eleven new resin glycosides, aquaterins I-XI (1-11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1-11 were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic acid B and operculinic acids A and ...
Giuliani Patricia P Department of Experimental and Clinical Sciences, "G. d'Annunzio" University, Chieti-Pescara, 29 via dei Vestini, NPD PalB, 66013, Chieti, - - 2014
Increasing body of evidence indicates that neuron-neuroglia interaction may play a key role in determining the progression of neurodegenerative diseases including Parkinson's disease (PD), a chronic pathological condition characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra. We have previously reported that guanosine (GUO) antagonizes MPP(+)-induced cytotoxicity ...
1 2 3 4 5 6 7 8 9 10 >