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Röhrborn Diana D Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Düsseldorf, - - 2014
Dipeptidyl peptidase 4 is an important drug target for diabetes and a novel adipokine. However, it is unknown how soluble DPP4 (sDPP4) is cleaved from the cell membrane and released into the circulation. We show here that MMP1, MMP2 and MMP14 are involved in DPP4 shedding from human vascular smooth ...
Cheng Xudong X College of Pharmacy, Nanjing University of Chinese Medicine, Jiangsu 210046, China; Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu 210028, - - 2014
The migration and invasion characteristics that are related to inflammatory response play important roles in the development of lung cancer. Astagaloside IV (AS-IV), an effective saponin component isolated from Astragali Radix, has been reported to inhibit metastasis of tumor cells. However, little is known about the underlying mechanism of AS-IV ...
Fan Yue-Chao YC Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu Province, People's Republic of China, - - 2014
This study was designed to explore the role of Cullin1 (Cul1) in the pathogenesis of human glioma and to investigate the role of Cul1 in the growth, migration and invasion of glioma cells. Expression of Cul1 in 191 glioma tissues, 8 normal brain tissues and 8 tumor adjacent normal brain ...
Tang Ying Y Department of Oncology, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, P.R. - - 2014
Overexpression of ABCG2 is considered a major mechanism of cancer drug resistance. Recent studies have shown that ABCG2 can regulate the switch between symmetric and asymmetric cell division in adult stem cells; however, the relationship between ABCG2 and cell division in drug-resistant cancer cells remains to be determined. In the ...
Guo Hua H Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of - - 2014
Survivin has multiple functions in the progression of cancer. The aim of the present study was to investigate the influence of YM155, a specific survivin inhibitor, on the biological behavior of U87 glioblastoma cells. The proliferative activity and growth rate of U87 cells were determined by colony formation assay and ...
Fanos Vassilios V Department of Surgery, Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Policlinico Monserrato, Azienda Ospedaliera Universitaria di Cagliari, University of Cagliari, 09042, Monserrato, CA, Italy, - - 2014
The development of the mammalian kidney is a complex and in part unknown process which requires interactions between pluripotential/stem cells, undifferentiated mesenchymal cells, epithelial and mesenchymal components, eventually leading to the coordinate development of multiple different specialized epithelial, endothelial and stromal cell types within the kidney architectural complexity. We will ...
Chin Chih-Chien CC Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, - - 2014
The CC chemokine receptor 6 (CCR6) and its ligand CCL20 are involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC. In addition, interleukin-17 (IL-17), produced by a T cell subset named "Th17," has been identified as an important player in inflammatory responses, and has emerged ...
Liao Yi-Chun YC Institute of Pharmacology, National Yang-Ming University, Taipei, 112, - - 2014
Inorganic arsenite (iAs) is a human carcinogen. Numerous studies have shown that mutation-activated H-Ras is frequently observed in human urothelial carcinomas. The interaction between iAs, an environmental factor, and H-Ras, an oncogene, is not clear. In this study, we explored the genotoxic effects of iAs in human urothelial cells ectopically ...
Terry Alan J AJ Division of Mathematics, University of Dundee, Dundee, DD1 4HN, UK, - - 2014
In animal cells, the transcription factor NF-[Formula: see text]B regulates many stressful, inflammatory, and innate immune responses. Experiments have revealed that, in response to cell stimulation, NF-[Formula: see text]B can exhibit oscillatory dynamics where the nature of these dynamics can influence the pattern of NF-[Formula: see text]B-dependent gene expression. Oscillations ...
Kenny Hilary A - - 2014
Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as the omentum, which are covered by a single layer of mesothelial cells. Mesothelial cells are generally thought to be "bystanders" to the metastatic process and simply displaced by OvCa cells to access the submesothelial extracellular matrix. Here, using ...
Wu C Y CY Department of Gastroenterology, Shenyang General Hospital of PLA, No. 83 Wenhua Road, Shenyang, 110016, - - 2014
KAI1 closely correlates with pancreatic cancer metastasis. There might be some factors that protect the cells from a proliferation inhibition by KAI1 in the solid tumors' microenvironment. Hypoxia and ischemia are the main characteristics of the microenvironment within solid tumors. Whether they affect the KAI1 inhibitory effects on cell proliferation ...
Sugimoto Naotoshi N Department of Physiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8640, Japan, - - 2014
The blood-brain barrier (BBB) selectively controls the homeostasis of the central nervous system (CNS) environment using specific structural and biochemical features of the endothelial cells, pericytes, and glial limitans. Glial cells, which represent the cellular components of the mature BBB, are the most numerous cells in the brain and are ...
Ryall Claire L CL Kingston University, United - - 2014
Understanding the mechanisms regulating islet growth and survival is critical for developing novel approaches to increasing or sustaining β cell mass in both type 1 and type 2 diabetes patients. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulation of cell ...
Zhu Beili B Department of Chemical Engineering and Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, USA; Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts, USA; Grass Center for Bioengineering, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, - - 2014
Skin stem cells resident in the bulge area of hair follicles and at the basal layer of the epidermis are multipotent and able to self-renew when transplanted into full-thickness defects in nude mice. Based on cell surface markers such as CD34 and the α6-integrin, skin stem cells can be extracted ...
Napsucialy-Mendivil Selene S Departamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 510-3, 62250 Cuernavaca, Morelos, - - 2014
ARABIDOPSIS HOMOLOG of TRITHORAX1 (ATX1/SDG27), a known regulator of flower development, encodes a H3K4histone methyltransferase that maintains a number of genes in an active state. In this study, the role of ATX1 in root development was evaluated. The loss-of-function mutant atx1-1 was impaired in primary root growth. The data suggest ...
Motté Evi E Brussels Free - - 2014
Beta cells generated from large-scale sources can overcome current shortages in clinical islet cell grafts provided they adequately respond to metabolic variations. Pancreatic (non)endocrine cells can develop from human embryonic stem (huES-)cells following in vitro derivation to pancreatic endoderm (PE) that is subsequently implanted in immune-incompetent mice for further differentiation. ...
Lee Woo-Yong WY Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1; Department of Physiology and - - 2014
CXCR6-GFP(+) cells, which encompass 70% invariant natural killer T cells (iNKT cells), have been found primarily patrolling inside blood vessels in the liver. Although the iNKT cells fail to interact with live pathogens, they do respond to bacterial glycolipids presented by CD1d on liver macrophage that have caught the microbe. ...
Pensa Sara S Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, - - 2014
Mammary gland involution involves a process that includes one of the most dramatic examples of cell death in an adult mammalian organism. We have previously shown that Stat3 regulates a lysosomal pathway of cell death in the first 48 hours of involution and induces lysosome leakiness in mammary epithelial cells. ...
Lee Jehn-Chuan JC Department of Otolaryngology, Mackay Memorial Hospital, Taipei, Taiwan, - - 2014
Oral squamous cell carcinoma (OSCC) is the most common phenotype of oral cancer. N-myc downstream regulated gene 1 (NDRG1) is a modulator for cell proliferation, differentiation, and invasion. The role and function of NDRG1 in OSCC cells remain inconclusive. The (3)H-thymidine incorporation and in vitro matrigel invasion assays revealed NDRG1-knockdown ...
Parsons Linda M LM Cell Cycle and Development Laboratory, Research Division, Peter MacCallum Cancer Centre, 7 St. Andrew's Place, East Melbourne, Melbourne, VIC 3002, Australia; Department of Genetics, University of Melbourne, 1-100 Grattan Street, Parkville, Melbourne, VIC 3010, - - 2014
The Drosophila melanogaster junctional neoplastic tumor suppressor, Lethal-2-giant larvae (Lgl), is a regulator of apicobasal cell polarity and tissue growth. We have previously shown in the developing Drosophila eye epithelium that, without affecting cell polarity, depletion of Lgl results in ectopic cell proliferation and blockage of developmental cell death due to deregulation ...
Parra Eduardo E Laboratory of Experimental Biomedicine, University of Tarapaca, Campus Esmeralda, Iquique, - - 2014
The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARF levels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification of EGR-1, TGF-β1 and p14ARF were observed in the two cell lines treated with different stimuli and ...
Le Cigne Anthony A Faculté des Sciences et des Techniques, UFIP UMR CNRS 6286 & Université de Nantes, 44322, Nantes Cedex 3, France; Division of Mechanism and Regulation of DNA Repair, Faculté des Sciences et des Techniques, UFIP UMR CNRS 6286 & Université de Nantes, 44322, Nantes Cedex 3, France; Division of Epigenetics: Proliferation and Differentiation, Faculté des Sciences et des Techniques, UFIP UMR CNRS 6286 & Université de Nantes, 44322, Nantes Cedex 3, - - 2014
The homologous recombination factor RAD51 is highly conserved. This criterion enabled us to identify a RAD51 ortholog in Physarum polycephalum. We found that the Physarum protein presents a high homology to the human protein and cross-reacted with antibodies directed against the human RAD51. Taking advantage of the natural synchrony of ...
Jiang Jing J EaStCHEM, School of Chemistry, Joseph Black Building, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK. - - 2014
Hypoxia is considered to be a reductive disorder of cells that is caused either by a lack of oxygen or by the dysregulation of metabolic pathways and is thought to play a role in the pathology of diseases including stroke and cancer. One aspect of hypoxia that remains poorly investigated ...
Takenaka Toru T Tsukuba Research Center, Taiho Pharmaceutical Co. - - 2014
Adult intestinal stem cells (ISC) possess both a long-term proliferation ability and differentiation capability into enterocytes. As a novel in vitro system for the evaluation of drug absorption, we characterized a human small intestinal epithelial cell (HIEC) monolayer that differentiated from adult ISC. Continuous proliferation/differentiation from ISC consistently conferred the ...
Overby Darryl R DR Department of Bioengineering, Imperial College London, London SW7 2AZ, United - - 2014
Increased flow resistance is responsible for the elevated intraocular pressure characteristic of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis that altered biomechanical behavior of Schlemm's canal (SC) cells contributes to this dysfunction. We used atomic force microscopy, optical magnetic twisting cytometry, and ...
Elric Julien J Institut Pasteur - CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux 75724 Paris Cedex 15, France; Université Pierre et Marie Curie, Cellule Pasteur UPMC, rue du Dr Roux, 75015 Paris, - - 2014
The centrosome position is tightly regulated during the cell cycle and during differentiated cellular functions. Because centrosome organizes the microtubule network to coordinate both intracellular organization and cell signaling, centrosome positioning is crucial to determine either the axis of cell division, the direction of cell migration or the polarized immune ...
Starich Todd A TA University of - - 2014
In all animals examined, somatic cells of the gonad control multiple biological processes essential for germline development. Gap junction channels, composed of connexins in vertebrates and innexins in invertebrates, permit direct intercellular communication between cells and frequently form between somatic gonadal cells and germ cells. Gap junctions comprise hexameric hemi-channels ...
Cozzolino Immmacolata I Department of Public Health, University of Naples Federico II, Naples, Italy. Electronic address: - - 2014
Osteoclast-like giant cells (OGCs) may occur in several types of breast carcinomas (BS). Neuroendocrine differentiation may be present in BS but, associated with OGCs, neuroendocrine differentiation has been rarely reported. A case of invasive ductal carcinoma with OGCs and neuroendocrine differentiation diagnosed by fine needle cytology (FNC) is described. A ...
Gao Guang-Gang GG College of Pharmacy, Jiamusi University, Jiamusi, 154007, - - 2014
Using an ultrasensitive chemically reduced graphene oxide and ionic liquid modified glass carbon electrode (RGI-GCE), separated electrochemical signals of adenine and hypoxanthine in both human breast cancer (MCF-7) and mouse embryonic fibroblast (BALB/3T3) cells were observed. Being the first time, low-level expression of purine bases in noncancerous BALB/3T3 cell can ...
Torii Tomohiro T Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, - - 2014
The myelin sheath insulates neuronal axons and markedly increases the nerve conduction velocity. In the peripheral nervous system (PNS), Schwann cell precursors migrate along embryonic neuronal axons to their final destinations, where they eventually wrap around individual axons to form the myelin sheath after birth. ErbB2 and ErbB3 tyrosine kinase ...
Park Jina J Nanobiotechnology Major, Korea University of Science and Technology, 52 Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of Korea; Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of - - 2014
We demonstrated that a metal-clad waveguide (MCW)-based biosensor can be applied to label-free measurements of viability of adherent animal cells with osmotic stimulation in real time. After Chinese hamster ovary (CHO) and human embryonic kidney cell 293 (HEK293) cells were attached to a Concanavalin A (Con A)-modified sensor surface, the ...
Liu Haisong H Shenzhen Stem Cell Engineering Laboratory, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, - - 2014
The applications of human pluripotent stem cell (hPSC)-derived cells in regenerative medicine has encountered a long-standing challenge: how can we efficiently obtain mature cell types from hPSCs? Attempts to address this problem are hindered by the complexity of controlling cell fate commitment and the lack of sufficient developmental knowledge for ...
Gentile C C Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Michele Cipolla 74, 90123, Palermo, Italy, - - 2014
Dietary approaches to control inflammatory bowel diseases (IBD) may include proanthocyanidin-rich foods. Our previous research showed that a hydrophilic extract from Sicilian pistachio nut (HPE) contains substantial amounts of proanthocyanidins and possesses anti-inflammatory activities. We studied the effects of HPE and of its polymeric proanthocyanidin fraction (PPF) in a cell ...
Williamson Sean R SR 1] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA [2] Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, MI, - - 2014
Rare renal epithelial neoplasms have been recognized to have an angioleiomyoma or leiomyoma-like proliferation of stromal smooth muscle; however, the nature of these tumors and their relationships to other renal cell carcinomas are poorly understood. We analyzed 23 such tumors for their clinicopathological, immunohistochemical, and cytogenetic features using fluorescence in ...
Meng Fanjie F Department of General Surgery, North-China Oil Field General Hospital, Hebei Medical University, Renqiu 062552, - - 2014
Ras mutations contribute to human cancer development. The present study assessed the Ras V12 mutation in hepatocellular carcinoma (HCC) cells and the role of its silencing in vitro and in nude mouse xenografts. HCC BEL7402 cells expressed mutations of V12 (Val/Gly) and wild-type H-Ras, whereas SMMC7721 cells only expressed wild-type H-Ras. ...
Erdman Nick N Clemson University, Department of Bioengineering, Clemson, SC 29634, - - 2014
The ability to place individual cells into an engineered microenvironment in a cell-culture model is critical for the study of in vivo relevant cell-cell and cell-extracellular matrix interactions. Microfluidics provides a high-throughput modality to inject various cell types into a microenvironment. Laser guided systems provide the high spatial and temporal ...
Chen Zhi Z Department of Orthopedics, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, P.R. - - 2014
Cullin 4B (CUL4B) is a component of the Cullin4B-Ring E3 ligase complex (CRL4B) that functions in proteolysis and is implicated in tumorigenesis. Here, we report that CUL4B is associated with tumorigenesis by promoting proliferation and inhibiting apoptosis of human osteosarcoma cells. We performed RNA interference (RNAi) with a lentiviral vector ...
Gonzalez-Villasana Vianey V Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer - - 2014
Pancreatic stellate cells (PSCs) have been recognized as the principal cells responsible for the production of fibrosis in PDAC. Recently PSCs have been noted to share characteristics with cells of monocyte-macrophage lineage (MML cells). Thus, we tested whether PSCs could be targeted with the nitrogen-containing bisphosphonates (NBPs) [pamidronate (Pam) or ...
Yamahira Shinya S Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, - - 2014
Cell patterning on photo-responsive materials are a promising tool for preparing unique single-cell arrays. However, most conventional single-cell arrays on such smart materials can be applied only to adherent cells and limit cellular functions such as extension and migration within the patterned adhesive surfaces. In this study, a versatile single ...
Chen Bojiang B Departments of Respiratory Medicine, Chengdu, China; Departments of State Key Laboratory of Biotherapy, Chengdu, - - 2014
Ribosomal protein S6 (rpS6), a component of the small 40S ribosomal subunit, has been found to be associated with multiple physiological and pathophysiological functions. However, its effects and mechanisms in non-small cell lung cancer (NSCLC) still remain unknown. Here, we showed that expressions of total rpS6 and phosphorylation rpS6 (p-rpS6) ...
Gerlach Jörg C JC Departments of Surgery and Bioengineering, University of Pittsburgh, - - 2014
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) has been shown to play an important role in liver development, cell proliferation and differentiation. It is, however, largely unknown, if C/EBPα regulates cell differentiation and proliferation differently in the diverse cell types of the human liver. We investigated the role of ...
He Yong Y School of pharmacy, Anhui key laboratory of bioactivity of natural products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune medicine (Anhui Medical University), Ministry of Education, Hefei 230032, P.R. China; Institute for Liver Diseases of Anhui Medical University(ILD-AMU). Anhui Medical University, Hefei 230032, - - 2014
Long noncoding RNAs (lncRNAs) are being increasingly recognized as major players in governing fundamental biological processes through diverse mechanisms. Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a lncRNA correlated with several human cancers. Recently, the methylation-dependent downregulation of MEG3 has been described in ...
Xie Xinyou X Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Key Laboratory of Biotherapy of Zhejiang Province, Zhejiang University, Hangzhou 310016, - - 2014
Nicotinamide N-methyltransferase (NNMT), an enzyme involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, has been found to be overexpressed in several malignancies, including colorectal cancer. However, the biological function of NNMT and the related mechanisms in colorectal cancer have not been elucidated. In the present study, ...
Bunse C E CE Institute for Transfusion Medicine, Hannover Medical School, Germany; Integrated Research and Treatment Centre Transplantation - IFB-Tx, Hannover Medical School, - - 2014
Heme oxygenase (HO)-1, the inducible isoform of HO, has immunomodulatory functions and is considered a target for therapeutic interventions. In the present study, we investigated whether modulation of HO-1 might have regulatory effects on in vitro T-cell activation. The study examined whether: (1) HO-1 induction by cobalt-protoporphyrin (CoPP) or inhibition ...
Yoritsune Ken-Ichi KI Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Fukuoka, 812-8581, - - 2014
The cell surface of Schizosaccharomyces pombe is negatively charged due to the presence of pyruvylated oligosaccharides, which is important for cell-cell recognition. However, the mechanism of pyruvate supply to oligosaccharides is not clearly understood. Here, we analyzed three putative phosphoenolpyruvate (PEP) transporter genes (pet1(+) , pet2(+) and pet3(+) ) in ...
Zhou Lei L Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Xi'an Jiao tong University, Xi'an - PR - - 2014
PSF1 is a subunit of the GINS complex which is essential for establishment of DNA replication forks, and the progression of the replisome. Previous studies have shown a close relationship between PSF1 and cell cycle in the proliferation of immature cells as well as tumors. The purpose of this study ...
Farrell Jeffrey A JA Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138; email: - - 2014
Many, if not most, embryos begin development with extremely short cell cycles that exhibit unusually rapid DNA replication and no gap phases. The commitment to the cell cycle in the early embryo appears to preclude many other cellular processes that only emerge as the cell cycle slows just prior to ...
Perica Karlo K Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA; Institute of Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD, - - 2014
Artificial Antigen Presenting Cells (aAPC) are engineered platforms for T cell activation and expansion, synthesized by coupling T cell activating proteins to the surface of cell lines or biocompatible particles. They can serve both as model systems to study basic aspects of T cell signaling and translationally as novel approaches ...
Coperchini Francesca F Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors and Chair of Endocrinology University of Pavia, Via S. Maugeri 10, 27100, Pavia, - - 2014
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are widely used perfluorinated chemicals (PFCs). Previous studies detected PFOA and PFOS in human tissues including the thyroid gland. There are no studies on the in vitro effects of PFOA and PFOS on thyroid cells. Our study was aimed at evaluating the effect ...
Antunes-Ricardo Marilena M Centro de Biotecnología-FEMSA., Tecnológico de Monterrey-, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849, Monterrey, N.L., - - 2014
(OFI) contains health-promoting compounds like flavonoids, being the isorhamnetin glycosides the most abundant. We evaluated the effect of OFI extracts with different isorhamnetin glycosides against two different human colon cancer cells (HT-29 and Caco2). The extracts were obtained by alkaline hydrolysis with NaOH at 40 °C during 15, 30 or 60 min. ...
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