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Xu Yunhua Y Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, P.R. - - 2014
The mitochondrial genome DNA copy number is critical for the functional maintenance of the mitochondria and energy acquisition for cell metabolism. Epithelial to mesenchymal transition (EMT) is an important process during embryonic development and has also been hypothesized to exhibit a significant role in cancer cell invasion and metastasis. In ...
Liu Dan D Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, 100084 Beijing, - - 2014
The germinal centre (GC) reaction supports affinity-based B-cell competition and generates high-affinity bone-marrow plasma cells (BMPCs). How follicular T-helper (TFH) cells regulate GC selection is not clear. Using competitive mixed chimaera, we show here that, beyond the role in promoting TFH development, ICOSL (inducible T-cell co-stimulator ligand, also known as ...
van Eyk Armorel Diane AD Division of Pharmacology, Department of Pharmacy and Pharmacology, University of the Witwatersrand , Parktown , South - - 2014
Abstract Context: Artificial sweeteners (AS) have been associated with tumor development (including colon cancer) in both animals and humans although evidence has been conflicting. Objectives: Additional research was thus conducted by studying the effects of 5 AS on the morphology, cell proliferation and DNA in cells by utilizing Caco-2, HT-29 ...
Furusawa Yukihiro Y Department of Biochemistry, Graduate School of Pharmaceutical Science, Keio University, Tokyo, 105-8512, - - 2014
Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous bacteria (SFB) facilitate the development of TH17 ...
Lee Chu-I CI Department of Medical Laboratory Science and Biotechnology, Fooyin University, 151 Jinxue Rd., Daliao Dist., Kaohsiung 83102, Taiwan, Republic of - - 2014
Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-d-glucan, three major effective components in A. camphorata extracts (ACE). ACE exhibited a selective cytotoxic effect on BxPC-3 human pancreatic cancer cells. ACE markedly inhibited the migration ability of ...
Jiang Qinglong Q Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, USA. - - 2014
Different lengths of rutile TiO2 nanowires (NW) with wide-open space for effective material filling were used as photoanodes for perovskite solar cells. Cells with 900 nm nanowires as photoanodes exhibit a current density of 22 mA cm(-2) and an efficiency of 11.7%, outperforming the reported TiO2 nanowire-based perovskite solar cells.
Fogli Laura K - - 2014
ABSTRACT Mantle cell lymphoma (MCL) is a rare B-cell malignancy that carries a relatively poor prognosis compared to other forms of non-Hodgkin's lymphoma. Standardized preclinical tools are desperately required to hasten the discovery and translation of promising new treatments for MCL. Through an initiative organized through the Mantle Cell Lymphoma ...
Vogt Niklas - - 2014
Abstract Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14)(q13;q32) leading to an overexpression of cyclin D1, a mediator of G1-S-phase transition. Thus MCL is regarded as a paradigm of lymphoma with a dysregulated cell cycle. The proliferation rate of MCL is in fact a strong predictor of outcome. ...
Groppelli Elisabetta E Division of Infection and Immunity, University College London, London, United - - 2014
Rapid HIV-1 spread between CD4 T lymphocytes occurs at retrovirus-induced immune cell contacts called virological synapses (VS). VS are associated with striking T cell polarization and localized virus budding at the site of contact that facilitates cell-cell spread. In addition to this, spatial clustering of organelles including mitochondria to the ...
Knight Laura M LM School of Molecular and Cellular - - 2014
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity of recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV Small and Large Tumour (ST and LT) antigens. Although a number of molecular ...
Umezu Tomohiro T Department of Molecular Science, Tokyo Medical University, Tokyo, Japan; - - 2014
Exosomes are small endosome-derived vesicles containing a wide range of functional proteins, mRNA, and miRNA. Exosomal miRNA from cancer cells helps modulate the microenvironment. In multiple myeloma (MM), the massive proliferation of malignant plasma cells causes hypoxia. To date, the majority of in vitro hypoxia studies of cancer cells have ...
Zovko Ana A Dep. Oncology/patology, Karolinska - - 2014
Marine derived compounds have been explored and considered as possible antitumor agents. In this study we analyzed extracts of the sponge Cribrochalina vasculum for their ability to inhibit tumor cell proliferation. Screening identified two acetylenic compounds of similar structure that showed strong tumor specific toxicity in non small cell lung ...
Hwang C C CC Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, - - 2014
Reovirus is a potent oncolytic virus in many human neoplasms that has reached phase II and III clinical trials. Our laboratory has previously reported the oncolytic effects of reovirus in canine mast cell tumour (MCT). In order to further explore the potential of reovirus in veterinary oncology, we tested the ...
Bir Aritri A Department of Biochemistry, Institute of Post Graduate Medical Education and Research, 244B A. J. C. Bose Road, Kolkata, 700020, - - 2014
This study has shown that purified recombinant human α-synuclein (20 μM) causes membrane depolarisation and loss of phosphorylation capacity of isolated purified rat brain mitochondria by activating permeability transition pore complex. In intact SHSY5Y cells, lactacystin (5 μM), a proteasomal inhibitor, causes an accumulation of α-synuclein with concomitant mitochondrial dysfunction ...
Gao Huiping H State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital,Shanghai Jiaotong University School of - - 2014
Purpose:The aim of our study is to elucidate whether T cells expressing GPC3-targeted chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their potential in the treatment of HCC. Experimental Design:T cells expressing a first generation and third generation GPC3-targeted CAR were prepared using lentiviral vector transduction. The ...
Robitaille Christina N CN INRS-Institut Armand-Frappier, Université du Québec, 531 boulevard des Prairies, Laval, QC, H7V 1B7, - - 2014
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic proprieties by determining their effects on proliferation, prostatic specific antigen (PSA) secretion and androgen receptor (AR) expression and AR phosphorylation in androgen-dependent LNCaP human prostate cancer cells, as well as on the expression and ...
Liu Aifeng A Cancer Research Institute University of South China, Hengyang, Hunan 421001, P.R. - - 2014
Nasopharyngeal carcinoma (NPC) has a highly increased incidence rate (20/100,000) in Southern regions of China, while being rare in the rest of the world. NPC is a malignant type of cancer due to its high occurrence rate of metastasis; however, biomarkers for effective diagnosis and treatment are yet to be ...
Zhao Pengjun P Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310002, P.R. - - 2014
Rhizoma paridis is widely used for cancer therapy due to its potential involvement in the suppression of tumor growth. However, at present there is no clear explanation for the mechanism underlying the inhibitory effects of Rhizoma paridis combined with hyperthermia on tumor growth. The aim of the present study was ...
Liu Songyang S Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. - - 2014
A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein associated with metastasis in a number of types of cancer. Little is known, however, regarding the role of ADAM10 in hepatocellular carcinoma (HCC). The aim of the present study was to evaluate whether downregulation of ADAM10 effects HCC cell proliferation, cell ...
Yamada Tomohiro T Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan, - - 2014
The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell ...
Zhao Qinfu - - 2014
A redox-responsive delivery system based on colloidal mesoporous silica (CMS) has been developed, in which 6-mercaptopurine (6-MP) was conjugated to vehicles by cleavable disulfide bonds. The oligosaccharide of hyaluronic acid (oHA) was modified on the surface of CMS by disulfide bonds as a targeting ligand and was able to increase ...
Liu Tong - - 2014
NiO-YSZ hollow fiber anode support with different microstructures has been prepared using a phase-inversion method. The effect of the solid loading of the phase-inversion suspensions on the microstructure development of the NiO-YSZ anode support has been investigated. Solid loading in the suspension has been found to have an important influence ...
Xiao Hui - - 2014
BackgroundHuman cells release nano-sized vesicles called exosomes, containing mRNA, miRNA and specific proteins. Exosomes from one cell can be taken up by another cell, which is a recently discovered cell-to-cell communication mechanism. Also, exosomes can be taken up by different types of cancer cells, but the potential functional effects of ...
Fan Bo-Yi BY State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of - - 2014
Eleven new resin glycosides, aquaterins I-XI (1-11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1-11 were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic acid B and operculinic acids A and ...
Giuliani Patricia P Department of Experimental and Clinical Sciences, "G. d'Annunzio" University, Chieti-Pescara, 29 via dei Vestini, NPD PalB, 66013, Chieti, - - 2014
Increasing body of evidence indicates that neuron-neuroglia interaction may play a key role in determining the progression of neurodegenerative diseases including Parkinson's disease (PD), a chronic pathological condition characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra. We have previously reported that guanosine (GUO) antagonizes MPP(+)-induced cytotoxicity ...
Wang Huan H Department of Chemical and Biological Engineering, 3415 Colorado Avenue, JSC Biotechnology Centre, 596 UCB, University of Colorado, Boulder, CO 80303, - - 2014
During every heartbeat, cardiac valves open and close coordinately to control the unidirectional flow of blood. In this dynamically challenging environment, resident valve cells actively maintain homeostasis, but the signalling between cells and their microenvironment is complex. When homeostasis is disrupted and the valve opening obstructed, haemodynamic profiles can be ...
Yoshida R R Department of Oral and Maxillofacial Surgery, Kumamoto University Graduate School of Life Sciences, Honjo 1-1-1, Chuo-ku, Kumamoto 860-8556, - - 2014
Background:Nucleostemin (NS) is essential for the maintenance of stem cell properties, the functions of which remain poorly understood in cancer cells. The purpose of this study was to explore the impact of NS on malignancy and its clinical significance in oral squamous cell carcinoma (OSCC) patients.Methods:We investigated the effects of ...
Raulf N N Department of Molecular Oncology, King's College London, Guy's Hospital Campus, Hodgkin Building, London SE1 1UL, - - 2014
Background:Current treatment strategies for head and neck cancer are associated with significant morbidity and up to 50% of patients relapse, highlighting the need for more specific and effective therapeutics. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and Smac mimetics (SMs) are promising anticancer agents, but their effect on head and neck ...
Kenicer Juliet - - 2014
Taxanes such as paclitaxel and docetaxel are used successfully to treat breast cancer, usually in combination with other agents. They interfere with microtubules causing cell cycle arrest; however, the mechanisms underlying the clinical effects of taxanes are yet to be fully elucidated. Isogenic paclitaxel resistant (PACR) MDA-MB-231, paclitaxel resistant ZR75-1 ...
Chang Renan R Department of Hepatobiliary Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, - - 2014
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Ubiquitin-proteasome system has been shown to play a pivotal role in the pathophysiology of HCC and other malignancies. UBE2Q1 is a putative E2 ubiquitin conjugating enzyme, and may be involved in the regulation of cancer-related proteins. In this ...
Coker-Gürkan Ajda A Molecular Biology and Genetics Department, Science and Literature Faculty, Istanbul Kultur University, Atakoy Campus, 34156, Istanbul, Turkey, - - 2014
Polyamines (PAs), such as putrescine, spermidine and spermine, are alkyl-amines that are essential for cell growth, proliferation, differentiation and cancer progression in eukaryotic cells. A designed PA analogue; DENSpm, induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells. Although the mechanism ...
Lange Ellen E Faculty of Biology, Morphology and Evolution of Invertebrates, Philipps-Universität Marburg, Karl-von-Frisch-Str. 8, 35032, Marburg, Germany, - - 2014
Guidance of cells and tissue sheets is an essential function in developing and differentiating animal tissues. In Hydra, where cells and tissue move dynamically due to constant cell proliferation towards the termini or into lateral, vegetative buds, factors essential for guidance are still unknown. Good candidates to take over this ...
Lu Tiangong T The University of - - 2014
ON01910.Na (Rigosertib, Estybon®), a styryl benzylsulfone, is a Phase III stage anti-cancer agent. This non-ATP competitive kinase inhibitor has multi-targeted activity, promoting mitotic arrest and apoptosis. Extensive Phase I/II studies with ON01910.Na, conducted in patients with solid tumours and haematological cancers demonstrate excellent efficacy. However, issues remain affecting its development. ...
Qu Xian X Cornell - - 2014
Size is a critical property of a cell, but how it is determined is still not well understood. The sepal epidermis of Arabidopsis thaliana contains cells with a diversity of sizes ranging from giant cells to small cells. Giant cells have undergone endoreduplication, a specialized cell cycle in which cells ...
Ravi Dashnamoorthy D Hematology/Oncology, Tufts Medical - - 2014
Purpose: Darinaparsin (Zio-101) is a novel organic arsenical compound with encouraging clinical activity in relapsed/refractory T-cell lymphoma (TCL) and Hodgkin lymphoma (HL), however little is known regarding its mechanism of action. Experimental Design: TCL cell lines (Jurkat, Hut78, and HH) and HL cell lines (L428, L540, and L1236) were examined ...
Wang Jingjing J Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. - - 2014
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma worldwide. Although patient outcomes have significantly improved to a greater than 40% cure rate by the combinatorial cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, which is widely used, resistance to the CHOP regimen continues to pose a ...
Shi Huaiping H College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, P.R. - - 2014
A number of studies have demonstrated that nocodazole suppresses Akt phosphorylation; however, the underlying molecular mechanism remains unclear. In the current study, the mechanism of nocodazole‑induced suppression of Akt phosphorylation was investigated. The cell cycle was analyzed using flow cytometry and EGF receptor dimerization was evaluated through a cross-linking assay. ...
Terasaki Hiroto H Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan - - 2014
Abstract We investigated the effect of thrombin on the secretion of vascular endothelial growth factor (VEGF), on cellular proliferation, and on the integrity of the barrier function of polarized retinal pigment epithelial (RPE) cells. In addition, we compared the responses of polarized to that of non-polarized RPE cells. Porcine polarized ...
Tian Ye Y Key Laboratory of Photochemical Conversion and Optoelectronic, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, - - 2014
Viral nanoparticles have attracted extensive research interests in diverse applications of diagnosis and therapy. In particular, filamentous M13 bacteriophages have shown great potential in biomedical applications. However, its pathways entering into cells still remain unclear, and this greatly hinders its further use as a drug or gene carrier. Here, a ...
Zahmatkesh Mona Haddad - - 2014
Ionizing radiation is the more effective therapy to reduce tumor growth through damaging the DNA of cells. In response to DNA damage, cells activate the checkpoint kinases such as CHK2, which signal to initiate repair processes and cell-cycle arrest, until the damaged DNA is repaired. At present, the development of ...
Wang Da-Hu DH Department of Dermatology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. - - 2014
The aim of the present study was to investigate the role of EphA2 in the carcinogenesis and progression of gastric carcinoma. Moreover, we aimed to determine the effect of geldanamycin (GA), an inhibitor of Hsp90, on the proliferation and apoptosis of human gastric carcinoma cells. Gastric carcinoma tissues, paired adjacent ...
Gong Xin X Department of Reproductive Endocrinology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, P.R. - - 2014
Uterine natural killer (uNK) cells are recruited into the uterus during establishment of the implantation and placentation of the embryo, and are hypothesized to regulate uterine spiral artery remodeling and angiogenesis during the initial stages of pregnancy. Failures in uNK cell activation are linked to diseases associated with pregnancy. However, ...
Slastnikova Tatiana A - - 2014
The review is devoted to a subcellular drug delivery system, modular nanotransporters (MNT) that can penetrate into target cells and deliver a therapeutic into their subcellular compartments, particularly into the nucleus. The therapeutics which need such type of delivery belong to two groups: (i) those that exert their effect only ...
Ampollini Luca L Thoracic Surgery, Department of Surgical Science, University Hospital of Parma, Parma, Italy - - 2014
The aim of the present study was to characterize the biological properties and in vivo tumourigenic potential of mesenchymal cells (MCs) obtained from non-small-cell lung cancer (NSCLC) samples. NSCLC samples (53 adenocarcinomas and 24 squamous-cell carcinomas) surgically removed from 46 males and 31 females were processed to identify mesenchymal cells ...
O'Leary Conor J CJ The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, 4072, - - 2014
A comprehensive understanding of adult neurogenesis is essential for the development of effective strategies to enhance endogenous neurogenesis in the damaged brain. Olfactory interneurons arise throughout life from stem cells residing in the subventricular zone of the lateral ventricle. Neural precursors then migrate along the rostral migratory stream (RMS) to ...
Jord Adel Al AA 1] Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, F-75005 Paris, France [2] Inserm, U1024, F-75005 Paris, France [3] CNRS, UMR 8197, F-75005 Paris, - - 2014
The semi-conservative centrosome duplication in cycling cells gives rise to a centrosome composed of a mother and a newly formed daughter centriole. Both centrioles are regarded as equivalent in their ability to form new centrioles and their symmetric duplication is crucial for cell division homeostasis. Multiciliated cells do not use ...
Li Hong-Wei HW Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, The Fourth Military Medical University, Xi'an, 710032, - - 2014
HAb18G/CD147 belongs to the immunoglobulin superfamily and predominantly functions as an inducer of matrix metalloproteinase secretion for tumor invasion and metastasis. This study was designed to investigate the effects of HAb18G/CD147 knockout on hepatocellular carcinoma cells using zinc-finger nuclease (ZFNs)-targeted gene knockout approach. The HCC cell line SMMC-7721 was used ...
Yang Yuan Y Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Department of Health Statistics, Second Military Medical University, Shanghai, China; National Innovation Alliance for Hepatitis & Liver Cancer, Shanghai, - - 2014
Pioglitazone (PGZ), a synthetic PPARγ ligand, is known to have anti-tumor activity. However, it is unclear how it acts against hepatocellular carcinoma (HCC). We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti-tumor process. To test this notion, human primary HCC tissues ...
Ginisty Aurélie A University of Poitiers, CNRS ERL 7368, Signalisation et Transports Ioniques Membranaires, 86073, Poitiers , cedex, 09, - - 2014
Neural stem cells, whose major reservoir in the adult mammalian brain is the subventricular zone (SVZ), ensure neuropoiesis, a process during which many generated cells die. Removal of dead cells and debris by phagocytes is necessary for tissue homeostasis. Using confocal and electron microscopy, we demonstrate that cultured SVZ cells ...
Martello Graziano G Wellcome Trust-Medical Research Council Stem Cell Institute - - 2014
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture but can reenter embryonic development seamlessly, differentiating on schedule to form all elements of the fetus. Here we review the properties of these remarkable ...
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