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Zhang Jing J MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, - - 2014
A general view is that Schizosaccharomyces pombe undergoes symmetric cell division with two daughter cells inheriting equal shares of the content from the mother cell. Here we show that CTP synthase, a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTP, can form filamentous cytoophidia in the ...
Martínez-Serrano María José MJ *Institut Clinic of Gynecology, Obstetrics and Neonatology, †Immunology Department, Centre de Diagnòstic Biomèdic, and ‡Institut Clinic of Hematologic Diseases and Clinical Oncology, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Faculty of Medicine-University of Barcelona, Barcelona, - - 2014
Current evidence suggests that the presence of tumor-initiating cells (TICs) in epithelial ovarian cancer (EOC) has a role in chemoresistance and relapse. Surface markers such as CD44/CD24, CD117, and CD133 expression have been reported as potential markers for TICs related to ovarian cancer and tumorigenic cell lines. In this study, ...
Majeed Hamid H Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, People's Republic of China, - - 2014
Flow cytometry exactly discriminated three subpopulations, i.e., viable, damage and sublethal cells of L. monocytogenes, S. aureus and E. coli when treated at their MIC values. Purity gum ultra (PGU) a large molecule surfactant-based CO nanoemulsion exerted significant impact on cellular subpopulations of L. monocytogenes and S. aureus, with more ...
Wan Jiawei J School of Physics and Technology, Wuhan University, Wuhan, Hubei, 430072, P.R. China; CAS Laboratory for Nanosystem and Hierarchy Fabrication, National Center for Nanoscience and Technology, Beijing, 100190, P.R. - - 2014
Pt-Ni alloy nanoparticles are synthesized and used as counter electrodes in dye-sensitized solar cells (DSSCs) for the first time. A PCE of 9.15% is achieved with the Pt3 Ni counter electrode, displaying an evident improvement compared with the conventional pure Pt (8.33%). The cell stability is also obviously increased with ...
Gutzman Jennifer H JH Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. Electronic address: - - 2014
During brain morphogenesis, the neuroepithelium must fold in specific regions to delineate functional units, and give rise to conserved embryonic brain shape. Individual cell shape changes are the basis for the morphogenetic events that occur during whole tissue shaping. We used the zebrafish to study the molecular mechanisms that regulate ...
Fang Su-Chiung SC Biotechnology Center in Southern Taiwan, Academia Sinica, Tainan County 741, Taiwan (S.-C.F., C.-L.C., C.-H.C.);Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan (S.-C.F., C.-L.C., C.-H.C.);Institute of Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan (C.-L.C.); andDonald Danforth Plant Science Center, St. Louis, Missouri 63132 (C.L.-P., J.G.U.) scfang@gate.sinica.edu.tw - - 2014
We previously identified a mutation, suppressor of mating type locus3 15-1 (smt15-1), that partially suppresses the cell cycle defects caused by loss of the retinoblastoma tumor suppressor-related protein encoded by the MAT3 gene in Chlamydomonas reinhardtii. smt15-1 single mutants were also found to have a cell cycle defect leading to ...
Meng Qing-Bin QB Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China; Department of Gastrointestinal Surgery,the First Hospital of Wuhan,Wuhan - - 2014
Objective To investigate the effects of eukaryotic translation initiation factor 5A2(EIF5A2)down-regulation by small interfering RNA(siRNA)on aggressiveness of human gastric cancer cell and its potential mechanisms. Methods The expressions of EIF5A2 in human gastric cancer cell lines(MKN28 and HGC27)and immortalized gastric mucosal epithelial cells(GES-1)were measured by real-time quantitative reverse transcription polymerase ...
Li Ying-Ji YJ Department of Hygiene and Public Health, Nippon Medical School, Tokyo, - - 2014
Epithelial-mesenchymal transition (EMT) is critical for embryonic development, and this process is recapitulated in adults during wound healing, tissue regeneration, fibrosis and cancer progression. Cell migration is believed to play a key role in both normal wound repair and in abnormal tissue remodeling. Prostaglandin E2 (PGE2) inhibits fibroblast chemotaxis, but ...
Zhang Yunjuan Y Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. - - 2014
Epigallocatechin‑3‑gallate (EGCG) is a constituent of green tea and has been associated with anticancer activity. In the present study, the inhibitory effect of EGCG on human hepatocellular cancer cells was examined by cell viability assay, in vitro apoptosis assay and cell cycle analysis. In addition, gene expression was measured to elucidate the ...
Zhang Hong-Fei HF State Key Laboratory of Medical Molecular Biology,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing - - 2014
Objective To investigate the role of TXNDC5 in serum starvation-induced proliferation inhibition of HeLa cell. Methods TXNDC5 was either over-expressed or knocked down by small interfering RNA(siRNA)in HeLa cells which were then cultured in conventional medium or serum starvation medium. The protein level of TXNDC5 was evaluated by Western blot ...
Sun A A Key Lab of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, - - 2014
A new ovarian cell line, CSO, was established from half-smooth tongue sole Cynoglossus semilaevis. Primary culture of CSO cells was initiated from digestion of ovarian tissues pieces by trypsin solution and cultured at 24° C in Dulbecco's modified Eagle's medium-F12 medium (DMEM-F12, 1:1) (pH 7·0), supplemented with 20% foetal bovine ...
Milton Claire C CC Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St. Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, University of Melbourne, Parkville, VIC 3010, - - 2014
The Salvador-Warts-Hippo (Hippo) pathway is an evolutionarily conserved regulator of organ growth and cell fate. It performs these functions in epithelial and neural tissues of both insects and mammals, as well as in mammalian organs such as the liver and heart. Despite rapid advances in Hippo pathway research, a definitive ...
Graupner Anne A Department of Chemicals and Radiation, National Institute of Public Health, Oslo 0456, Norway,Department of Plant and Environmental Sciences, University of Life Sciences, Aas 1430, Norway, andLitron Laboratories, Rochester, NY 14623, - - 2014
Many studies have investigated genotoxic effects of high Se diets but very few have addressed the genotoxicity of Se deprivation and its consequences in germ cells and none in somatic cells. To address these data gaps, C57BL/6 male mice were subjected to Se deprivation starting in the parental generation, i.e. ...
Iskratsch Thomas T 1] Department of Biological Sciences, Columbia University, New York 10027, USA. - - 2014
Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces ...
Satué María M Group of Cell Therapy and Tissue Engineering, Research Institute on Health Sciences (IUNICS). University of Balearic Islands, Palma de Mallorca, - - 2014
The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on metabolic activity ...
Liu Yan Y Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409-1061, - - 2014
A microfluidic chip containing stamped antibody arrays was developed for simultaneous cell separation and drug testing. Poly(dimethyl siloxane) (PDMS) stamping was used to deposit antibodies in a microfluidic channel, forming discrete cell-capture regions on the surface. Cell mixtures were then introduced, resulting in the separation of cells when specific antibodies ...
Umesalma Syed S Department of Biochemistry, Cell Biology Unit, University of Madras, Maraimalai Campus (Guindy), Chennai, 600 025, Tamil Nadu, India, - - 2014
Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of human cancer. Ellagic acid (EA) has been known for its chemopreventive activity against various cancers and numerous investigations have shown its apoptotic activity both in vivo and in vitro. The present study was focused ...
Venza Mario M Department of Experimental Specialized Medical and Surgical and Odontostomatology Sciences, University of Messina, Messina, - - 2014
Cadmium (Cd) is a human carcinogen that likely acts via epigenetic mechanisms. However, the precise role of Cd in melanoma remains to be defined. The goals of this study are to: (i) examine the effect of Cd on the proliferation rate of cutaneous and uveal melanoma cells; (ii) identify the ...
Deák Magdolna M Department of Rheumatology, University of Szeged, Faculty of Medicine, Albert Szent-Györgyi Health Centre, Szeged, - - 2014
Secreted, extracellular galectin-1 (exGal-1) but not intracellular Gal-1 (inGal-1) has been described as a strong immunosuppressive protein due to its major activity of inducing apoptosis of activated T-cells. It has previously been reported that T-cells express Gal-1 upon activation, however its participation in T-cell functions has remained largely elusive. To ...
Demir Zeynep Z Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, - - 2014
Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purines (15-27), 9-(p-toluenesulfonyl/cyclopentyl/ethoxycarbonylmethyl)-6-(substituted amino/piperazino)purines (28-34, 36, 37, 38-41) were synthesized and evaluated initially for their cytotoxic activities on liver Huh7, breast T47D and colon HCT116 carcinoma cells. N(6)-(4-Trifluoromethylphenyl)piperazine derivative (17) and its 9-(p-toluene-sulfonyl)/9-cyclopentyl analogues (28, 36) had promising cytotoxic activities. Compounds 17, 28 and 36 ...
Wilkinson David G DG a Division of Developmental Neurobiology, MRC National Institute for Medical Research , London , - - 2014
Abstract There is increasing evidence that in addition to having major roles in morphogenesis, in some tissues Eph receptor and ephrin signaling regulates the differentiation of cells. In one mode of deployment, cell contact dependent Eph-ephrin activation induces a distinct fate of cells at the interface of their expression domains, ...
Maghsoudlou Panagiotis P Stem Cells and Regenerative Medicine Section, UCL Institute of Child Health and Surgery Unit, Great Ormond Street Hospital, 30 Guilford Street, London, WC1N 1EH, - - 2014
Long-gap esophageal atresia represents a significant challenge for pediatric surgeons and current surgical approaches are associated with significant morbidity. A tissue-engineered esophagus, comprising cells seeded onto a scaffold, represents a therapeutic alternative. In this study, we aimed to determine the optimal techniques for isolation and culture of mouse esophageal epithelial ...
Kang Hongjun H Key Laboratory of PLA, Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, P.R. - - 2014
The aim of the current study was to explore the application of microcarrier technology in the rapid amplification and chondrogenic differentiation of human adipose‑derived stem cells (ADSCs) in a rotating bioreactor. Human ADSCs were cultivated with Cytodex 3 microcarriers in a rotary cell culture system (RCCS), and using inverted and scanning ...
Xiao Xiangwei X Division of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, - - 2014
Genetic manipulations, with or without lineage tracing for specific pancreatic cell types, are very powerful tools for studying diabetes, pancreatitis and pancreatic cancer. Nevertheless, the use of Cre/loxP systems to conditionally activate or inactivate the expression of genes in a cell type- and/or temporal-specific manner is not applicable to cell ...
Zhang Yunlei Y a Centre of Biological Engineering, University of Minho, Braga Portugal and College of Life Science, Hunan Provincial Key Laboratory of Microbial Molecular Biology-State Key Laboratory Breeding Base of Microbial Molecular Biology , Hunan Normal University , Changsha , - - 2014
Lactoferrin (LF) is predominantly found in mammalian secretions with recognized anticancer potential, although the mechanisms involved in such activity are still unclear. Here, the stability, internalization, and cytotoxicity of bovine LF (bLF) and its variants were tested against a panel of breast cancer cells. bLF was found to be very ...
Tsiantoulas Dimitrios D From the Department of Laboratory Medicine, Medical University of Vienna, Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria (D.T., C.J.B.); and Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S., - - 2014
Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main families: the B1 and the B2 cells. B1 cells are atheroprotective mainly via the production of natural IgM antibodies that bind oxidized low-density lipoprotein and apoptotic cells. ...
Du Feng F Department of Nephrology, Shengjing Hospital, China Medical University, Shenyang 110004, China - - 2014
The epithelial-mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like cells plays a substantial role in renal tubulointerstitial fibrosis, which is a common pathological character of end-stage renal disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT in tubular epithelial cells and increases Bcl-2-associated athanogene 3 (BAG3) expression in neural progenitor ...
Gargiulo Lucía L Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490, C1428ADN, CABA, - - 2014
Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast ...
Weng Tingting T University of Texas-Houston Medical School, Houston, United States ; - - 2014
Rationale: Idiopathic Pulmonary Fibrosis (IPF) is a deadly lung disease with few therapeutic options. Apoptosis of alveolar epithelial cells, followed by abnormal tissue repair characterized by hyperplastic epithelial cell formation, is a pathogenic process that contributes to the progression of pulmonary fibrosis. However, the signaling pathways responsible for increased proliferation ...
Nakamura Mai M Graduate School of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun, Gunma, 374-0193, - - 2014
Mouse embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have the ability to differentiate in vitro into various cell lineages including neurons. The differentiation of these cells into neurons has potential applications in regenerative medicine. Previously, we reported that a chick dorsal root ganglion (DRG)-conditioned medium (CM) promoted ...
Vaitkuviene Aida A Department of Physical Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Zygimantu 9, LT-01102 Vilnius, - - 2014
Diamond nanoparticles (DNPs) are very attractive for biomedical applications, particularly for bioimaging. The aim of this study was to evaluate the impact of DNPs on neural cancer cells and thus to assess the possible application of DNPs for these cells imaging. For this purpose, the neuroblastoma SH-SY5Y cell line was ...
Parker J Brandon JB Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, - - 2014
Host cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle progression and cell proliferation. Current models suggest a mechanism whereby HCF-1 functions as a direct coregulator of E2F proteins, facilitating the expression of genes necessary for cell proliferation. In this report, we show that HCF-1 recruitment to numerous ...
Matoba Shogo S Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, - - 2014
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT embryos fail to develop to term due to undefined reprogramming defects. Here, we identify histone H3 lysine 9 trimethylation (H3K9me3) of donor cell genome as a ...
Perez White Bethany E BE a Departments of - - 2014
Abstract Epithelial cells are tightly coupled together through specialized intercellular junctions, including adherens junctions, desmosomes, tight junctions, and gap junctions. A growing body of evidence suggests epithelial cells also directly exchange information at cell-cell contacts via the Eph family of receptor tyrosine kinases and their membrane-associated ephrin ligands. Ligand-dependent and ...
Taylor P P Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Apartado 20632, Caracas 1020-A, Venezuela. Electronic address: - - 2014
Inhibition assays on tumour cells in vitro are commonly used to confirm the activity of extracts, fractions and compounds from plants reported to be antitumoural. The majority of assays report the IC50 (50% inhibitory concentration), whereas others distinguish between inhibition of cell proliferation (cytostasis) and cell death (cytotoxicity). Here, we ...
Choi Soon Won SW Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Republic of - - 2014
The retinal pigment epithelium (RPE) is a highly specialized cell type located between the choroid and neural retina of the eye. RPE degeneration causes irreversible visual impairment, extending to blindness. Cell therapy has recently emerged as a potential therapeutic approach for retinal degeneration. MicroRNA-based differentiation of stem cells is a ...
Horita Nobukatsu N Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, - - 2014
The dynamics of intestinal stem cells are crucial for regulation of intestinal function and maintenance. Although crypt stem cells have been identified in the intestine by genetic marking methods, identification of plural crypt stem cells has not yet been achieved as they are visualised in the same colour. Intestinal organoids ...
Chu Jia-Hui JH Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, - - 2014
Sphingosine kinase 2 (SphK2) is a type of sphingosine kinase, which express highly in most of cancers. SphK2 produce sphingosine-1-phosphate (S1P) and then accumulate in cancer cells. Our previous study showed that S1P antagonized the effects of all-trans-retinoic acid (ATRA) via the receptor-dependent and independent pathway. In this study, we aimed ...
Berger Carolina C Clinical Research Division - Program in Immunology, Fred Hutchinson Cancer Research Center - - 2014
Genetic engineering of T cells for adoptive transfer by introducing a tumor-targeting chimeric antigen receptor (CAR) is a new approach to cancer immunotherapy. A challenge for the field is to define cell surface molecules that are both preferentially expressed on tumor cells and can be safely targeted with T cells. ...
Zhou Zhou Z Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, - - 2014
The functions of the actin-myosin-based contractile ring in cytokinesis remain to be elucidated. Recent findings show that in the fission yeast Schizosaccharomyces pombe, cleavage furrow ingression is driven by polymerization of cell wall fibers outside the plasma membrane, not by the contractile ring. Here, we show that one function of ...
Yan Xiaomin X State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. - - 2014
Triptolide is a diterpene triepoxide, extracted from the Chinese herb Tripterygium wilfordii Hook F, which has been shown to have antitumor activity in a number of cancers. Neuroblastoma is an aggressive extracranial pediatric solid tumor, with significant chemotherapeutic resistance. In this study, triptolide was hypothesized to be a potential therapeutic ...
Rabineau Morgane M INSERM UMR 1121, 11 rue Humann, 67085 Strasbourg, France; Faculté de Chirurgie Dentaire, Université de Strasbourg, 8 rue Sainte-Elisabeth, 67000 Strasbourg, France; Fédération de Médecine Translationnelle, Strasbourg, - - 2014
Substrate stiffness is known to strongly influence the fate of adhering cells. Yet, little is known about the influence of the substrate stiffness on chromatin. Chromatin integrates a multitude of biochemical signals interpreted by activation or gene silencing. Here we investigate for the first time the organization of chromatin of ...
Chanvorachote Pithi P Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand, - - 2014
Caveolin-1 (Cav-1), a protein component of cellular membrane, has been reported to regulate several cancer cell behaviors. However, its role on cancer metastasis in anoikis resistant cells is unknown. The present study aimed to investigate the correlation between Cav-1 level and aggressive behaviors of anoikis resistant cancer cells. Cav-1 and ...
Xiao Wenkai W Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. - - 2014
Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to inhibit tumor cell proliferation and induce apoptosis in cancer models in vitro and in vivo. In the present study, tetrandrine significantly inhibited the proliferation of mouse endothelial cells (EOMA cell) and induced G1/S arrest in EOMA cells, in which the expressions of cyclin D and cyclin E ...
Mitchell Ryan K RK Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, - - 2014
Type 2 diabetes (T2D) is characterised by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. Whilst deletion of the homologous murine Tcf7l2 gene throughout the developing pancreas leads to ...
Li Jason Z JZ Virginia Tech CRC, Blacksburg, VA, - - 2014
Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. However, the exact mechanisms of this effect remain largely unknown. Using chemiluminescence ...
Fan Gui-Ling GL Department of Gastroenterology, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. - - 2015
Low expression levels of the programmed cell death 5 (PDCD5) gene have been reported in numerous human cancers, however, PDCD5 expression has not been investigated in hepatic cancer. The present study aims to investigate the biological behavior of PDCD5 overexpression in hepatocellular carcinoma (HCC) cells. The PDCD5 gene was stably ...
Morimoto Ayumi A Department of Clinical Laboratory, Toki General Hospital, Toki, - - 2014
Objective: To evaluate the expression of antibodies against calretinin, cytokeratin 5/6, desmin, D2-40, HBME-1, mesothelin, thrombomodulin, WT1, Ber-EP4, CEA, EMA and MOC-31 individually and to compare it with a new rapid procedure for fluorescence immunocytochemistry (ICC) using liquid-based cytology (LBC). Study Design: Sixty-four peritoneal cell specimens prepared with the LBC ...
Kim Dong Hwa DH Department of Orthopaedic Surgery, University of Pennsylvania, McKay Orthopaedic Research Laboratory, 36th Street and Hamilton Walk, 424 Stemmler Hall, Philadelphia, PA 19104-6081, USA; Translational Musculoskeletal Research Center, Philadelphia VA Medical Center, 3900 Woodland Avenue, Building 21, Room A200, Philadelphia, PA 19104, - - 2014
Degradation of the nucleus pulposus (NP) is an early hallmark of intervertebral disc degeneration. The capacity for endogenous regeneration in the NP is limited due to the low cellularity and poor nutrient supply of this avascular tissue. Towards restoring the NP, a number of biomaterials have been explored for cell ...
He Youdi Y Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. - - 2014
Mounting evidence has suggested that inflammation associated with interleukin (IL)‑6 and T‑helper (Th)17 cells, has a role in the development of atherosclerotic cerebral infarction (ACI). However, it remains unclear which population of cells determines the levels of IL‑6, and the role of IL‑6‑secreting cells in inducing Th17 cell production. In the present ...
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