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Results 451 - 500 of 2571
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Wang Xiao-Hu XH Medical School of Southeast University, Nanjing 210009, Jiangsu, - - 2014
Although tumor necrosis factor alpha (TNF-α) is known to play a critical role in intervertebral disc (IVD) degeneration, the effect of TNF-α on nucleus pulposus (NP) cells has not yet been elucidated. The aim of this study was to explore the effect of TNF-α on proliferation of human NP cells. ...
Yang Nai-Di ND National University of Singapore, - - 2014
Artesunate (ART) is an anti-malaria drug that has been shown to exhibit anti-tumor activity and functional lysosomes are reported to be required for ART-induced cancer cell death while the underlying molecular mechanisms remain largely elusive. In this study, we aimed to elucidate the molecular mechanisms underlying ART-induced cell death. We ...
da Silva Marcondes Daniela Beck DB Programa de Pós-graduação em Ciências Farmacêuticas. Universidade Federal do Paraná. Av. Lothário Meissner, 632. Jardim Botânico - 80210-170 - Curitiba - PR - Brazil. Electronic address: - - 2014
The stem barks of Lafoensia pacari have been traditionally used not only by South Amerindians but also by Brazilian and Paraguayan populations for treating a variety of unhealthy conditions to which their biological potential has been scientifically documented in several reports over the last decade. Although its anticancer usage is ...
Liang Xiao X The Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, - - 2014
Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells (TICs) is still problematic. This study investigated possibilities to isolate a population of cancer cells with tumour initiating properties based on their adherence ...
Wang Xing X Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. - - 2014
Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. OAZ1 is also involved in other major cellular events, including differentiation and apoptosis. Recent studies have shown that OAZ1 has tumor suppressor activities and its effects on cell proliferation and ...
Zhang Chenjing C Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. - - 2014
The aim of the present study was to investigate the effect of cantharidin (CTD) on human gastric cancer cells and to explore the underlying mechanisms of these effects. The human gastric cancer SGC-7901 and BGC-823 cell lines were treated with CTD. MTS assays were then employed to examine cellular proliferation, ...
Ye Lan L Cancer Center, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
Radiotherapy is the main locoregional control modality for a number of types of malignant tumors, including glioblastoma. However, radiotherapy fails to prevent recurrence in numerous patients due to the intrinsic radioresistance of cancer cells. Cell senescence is significant in tumor suppressor mechanisms and is closely associated with the radioresistance of ...
Kawaguchi Tsukasa T Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, - - 2014
CD26 is a membrane glycoprotein that has multiple functions, including dipeptidyl peptidase IV activity. CD26 expression varies in different tumor types, and its role in tumor growth in hepatocellular carcinoma (HCC) remains unclear. CD26 expression levels were examined in resected HCCs and surrounding non-cancerous lesions. The effect of CD26 knockdown ...
Jin Jing J State Key Laboratory of Military Stomatology, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, People's Republic of - - 2014
Root resorption during orthodontic treatment is a complex and sterile inflammatory process, which is characterized by the recruitment of mononuclear cells in the local periodontal ligament. This study aimed to investigate whether interleukin (IL)-1β could induce the migration of monocytes through upregulating monocyte chemoattractant protein (MCP)-1 expression in human periodontal ...
Kilinc Devrim D UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, - - 2014
Multifunctional nanoparticles that actively target-specific tissues are studied for cancer diagnosis and treatment. Magnetically and optically active particles are of particular interest because they enable multiple imaging modalities and physically modulated therapies, such as magnetic hyperthermia. Fe-Au nanorods are synthesized that have a long iron segment, coated with polyethylene glycol, ...
Oka Hiroko H Department of International Collaboration Development for Dentistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku Hiroshima, 734-8553, - - 2014
Background: F-spondin, known as a secreted neuronal glycoprotein, is highly expressed on the tooth root surface and we had reported F-spondin is one of the specific markers of cementoblasts in periodontal tissue. In chronic periodontitis, significant cemental resorption rarely occurs on the root side, although alveolar bone resorption by osteoclasts ...
Fülbier Angela - - 2014
Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cells. Therefore, we used this technique to transfect ASCs with a vector encoding for Ambystoma mexicanum epidermal lipoxygenase (AmbLOXe) which is ...
Xiong Fengzhu F Department of Systems Biology, Harvard Medical School, Boston, MA 02115, - - 2014
Epithelial cells acquire functionally important shapes (e.g., squamous, cuboidal, columnar) during development. Here, we combine theory, quantitative imaging, and perturbations to analyze how tissue geometry, cell divisions, and mechanics interact to shape the presumptive enveloping layer (pre-EVL) on the zebrafish embryonic surface. We find that, under geometrical constraints, pre-EVL flattening ...
Buszczak Michael M Department of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, - - 2014
Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.
Tegha-Dunghu Justus - - 2014
Understanding the molecular basis for proper cell division requires a detailed functional analysis of microtubule (MT) associated proteins. MT associated protein 1S (MAP1S), the most ubiquitously expressed MAP1 family member, is required for accurate cell division. Using quantitative analysis of MT plus end tracking we show here that MAP1S knockdown ...
Long Xin Hua XH Department of Orthopedics, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. - - 2014
Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus. The aim of this study was to investigate the combined inhibitory ...
Romano Nicole H NH Materials Science and Engineering Department, Stanford University, Stanford, CA 94305, USA. Electronic address: - - 2014
The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap. Many current strategies to stimulate regeneration take inspiration from this biological response, however, little is known about the balance of cell-matrix and Schwann cell-neurite dynamics required for ...
Salvador-Membreve Daile Meek C DM Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101, - - 2014
Trichomonas vaginalis, the causative agent of trichomoniasis is generally known to inhabit the genitourinary tract. However, several case reports with supporting molecular and immunological identifications have documented its occurrence in the respiratory tract of neonates and adults. In addition, the reports have documented that its occurrence is associated with respiratory ...
Jiang Qiying Q Department of Immunology, Basic Medical College of Zhengzhou University, Zhengzhou, Henan 450052, P.R. - - 2014
Heat shock factor 1 (HSF1), a main regulator of the heat shock response in eukaryotes, increases cell survival in numerous pathophysiological conditions. The aim of the present study was to o bserve the function of defective HSF1 expression in HEK293T cells. shRNA of human HSF1 was constructed into the retroviral vector ...
Jakab Martin M Institute of Physiology and Pathophysiology, Laboratory of Functional and Molecular Membrane Physiology, Paracelsus Medical University Salzburg, Salzburg, - - 2014
Background/Aims: The ATP12A gene codes for a non-gastric H(+)/K(+) ATPase, which is expressed in a wide variety of tissues. The aim of this study was to test for the molecular and functional expression of the non-gastric H(+)/K(+) ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 ...
Orchard-Webb David J - - 2014
Deregulated expression of the transmembrane glycoprotein CDCP1 (CUB domain-containing protein-1) has been detected in several cancers including colon, lung, gastric, breast, and pancreatic carcinomas. CDCP1 has been proposed to either positively or negatively regulate tumour metastasis. In this study we assessed the role of CDCP1 in properties of cells that ...
Ni Sujie S Department of Medical Oncology, Shanghai Cancer Center, Fudan University, No. 270 Dong An Road, Shanghai, 200032, - - 2014
NF45 (also known as ILF2), as one subunit of NF-AT (nuclear factor of activated T cells), repairs DNA breaks, inhibits viral replication, and also functions as a negative regulator in the microRNA processing pathway in combination with NF90. Recently, it was found that implicated in the mitotic control of HeLa ...
Feist Richard M RM Jr Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, 35294, - - 2014
The aim of this work is to evaluate the abundance, origins, and phenotypes of actively proliferating cells in proliferative diabetic retinopathy (PDR). Eleven epiretinal membranes from patients undergoing surgery for PDR were evaluated by indirect immunofluorescence for evidence of cell proliferation using the nuclear cell proliferation marker Ki67 and for ...
Wang Juan J Department of Pathology, The Second Hospital of Hebei Medical University, No. 215, Heping Western Road, Shijiazhuang, Hebei Province, People's Republic of - - 2014
Sterigmatocystin (ST), a mycotoxin commonly found in food and feed commodities, has been classified as a "possible human carcinogen." Our previous studies suggested that ST exposure might be a risk factor for esophageal cancer and that ST may induce DNA damage and G2 phase arrest in immortalized human esophageal epithelial ...
Ziegler Elke E Department of Gynecology and Obstetrics, Georg-August-University, Robert-Koch-Street 40, 37075, Göttingen, - - 2014
Epithelial-mesenchymal transition (EMT) is a cellular development program characterized by loss of cell adhesion and increased cell mobility. It is essential for numerous processes including metastasis. In this study we have generated "aggressive" MCF-7 breast cancer cells (MCF-7-EMT), which show significantly increased invasion in contrast to wild type MCF-7 (MCF-7 ...
Gegg Moritz M Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Munich, - - 2014
Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. Here, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated during PCP acquisition in ciliated tissues. Fltp knock-out mice show BB docking and ciliogenesis defects in multiciliated lung ...
Hu Qirui Q Center for Stem Cell Biology and Engineering and Center for Nanomedicine and Sanford-Burnham Medical Research Institute, University of California Santa Barbara, Santa Barbara, California, USA; Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, - - 2014
Somatic cells can be reprogrammed to an altered lineage by overexpressing specific transcription factors. To avoid introducing exogenous genetic material into the genome of host cells, cell-penetrating peptides can be used to deliver transcription factors into cells for reprogramming. Position-dependent C-end rule (CendR) cell- and tissue-penetrating peptides provide an alternative ...
Twyffels Laure L Free University of Brussels - - 2014
Iodide is captured by thyrocytes through the Na(+)/I(-) symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen. ...
Ding Qiong J QJ Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, United - - 2014
Purpose: Loss or dysfunction of trabecular meshwork (TM) cells has been associated with the development of pathologically elevated IOP and it is conceivable that replacement of damaged TM cells could restore function to the TM. We propose that the use of TM-like cells derived from induced pluripotent stem cells (iPSCs) ...
Plak Katarzyna K Department of Cell Biochemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, the - - 2014
Cytokinesis is the final step of mitosis when a mother cell is separated into two daughter cells. Major cytoskeletal changes are essential for cytokinesis, it is however not well understood how the microtubules and actin/myosin cytoskeleton are exactly regulated in time and space. Here we show that during early stages ...
Itou Junji J Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: - - 2014
Proliferation analysis is one of the basic approaches to characterize various cell types. In conventional cell proliferation assays, the same sample cannot be observed over time, nor can a specific group within a heterogeneous population of cells, for example, cancerous cells, be analyzed separately. To overcome these limitations, we established ...
Wang Zhibin Z Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310-2870, - - 2014
Functionalization and assembly of live cells with microfabricated polymeric biomaterials have attracted considerable interests in recent years, but the conventional methods suffer from high cost, high complexity, long processing time or inadequate capability. This present study reports on the development of a novel method for functionalizing and assembling live cells ...
Sara Molladavoodi M Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1. Electronic address: - - 2014
It has been previously reported that mechanical stimulus can affect cellular behavior. While induced differentiation in stem cells, and proliferation and directional migration in fibroblasts are reported as responses to mechanical stimuli, little is known about the response of cells from the cornea. In the present study, we investigated whether ...
Tiernan Aubrey R AR School of Chemical & Biomolecular Engineering, Georgia Institute of - - 2014
Histone deacetylase inhibitors (HDACi) were recently identified as having significant clinical potential in reversing β-cell functional inhibition caused by inflammation, a shared precursor of Type 1 and Type 2 diabetes. However, HDACi are highly complex and little is known of their direct effect on important cell secretion pathways for blood ...
Hou Chunfeng C Department of Rheumatology, Jining First people's Hospital, Jining, Shandong 272111, PR - - 2014
MicroRNA let-7i is up-regulated in T cells from patients with Ankylosing Spondylitis (AS). In this study, we investigated the role of let-7i in T cells survival. Our results demonstrated down-regulation of insulin-like growth factor-1 receptor (IGF1R) in T cells from patients with AS. Luciferase reporter assay suggested IGF1R as direct ...
Nelson Charles C Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, - - 2014
Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell survival and cell death, but little is known about the mechanisms that distinguish its use during these distinct cell fates. Here, we identify the microRNA miR-14 as being both necessary ...
Kim In Gyu IG Department of Radiation Biology, Environment Radiation Research Group, Korea Atomic Energy Research Institute, Yuseong, Daejeon 305‑600, Republic of - - 2014
Various mechanisms have been proposed to underlie the cellular activity of genistein, based on biological experiments and epidemiological studies. The present study demonstrated that genistein inhibited the expression of cytoplasmic nicotinamide adenine dinucleotide phosphate (NADP)‑dependent isocitrate dehydrogenase (cICDH), thus increasing levels of intracellular reactive oxygen species (ROS) in human promyeloid ...
Poukkula Minna M Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014 Helsinki, - - 2014
Lamellipodia are dynamic actin-rich cellular extensions that drive advancement of the leading edge during cell migration [1-3]. Lamellipodia undergo periodic extension and retraction cycles [4-8], but the molecular mechanisms underlying these dynamics and their role in cell migration have remained obscure. We show that glia-maturation factor (GMF), which is an ...
Li Xuefeng X Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, P. R. China 310014. zhuq@zjut.edu.cn - - 2014
Novel FRET-based small molecule probes targeting monoamine oxidases (MAOs) were designed and synthesized. These "Turn-ON" fluorescent probes were proved to be capable of directly reporting MAO activities in live mammalian cells.
Bronietzki Alisha W AW 1] Systems-Oriented Immunology and Inflammation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany [2] Institute for Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg, - - 2014
Autophagy is a vital catabolic process for degrading bulky cytosolic contents, which cannot be resorbed via the proteasome. First described as a survival mechanism during nutrient starvation conditions, recent reports have demonstrated that autophagy supports metabolic functions of T cells at various stages of maturation and effector function. Autophagy is ...
Weng Wen-Chin WC Department of Pediatrics, College of Medicine, National Taiwan University Hospital and National Taiwan University, Taipei, - - 2014
Calreticulin (CRT) has been previously correlated with the differentiation of neuroblastoma (NB), implying a favorable prognostic factor. Vascular endothelial growth factor (VEGF) has been reported to participate in the behavior of NB. This study investigated the association of CRT and VEGF-A in NB cells. The expressions of VEGF-A and HIF-1α, ...
Fu Yuejun Y Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, People's Republic of China, - - 2014
Deleterious invasiveness of glioma cells into the normal brain tissue is endorsed by its inherent ability to regulate the receptor-mediated adhesive properties, extracellular matrix degradation and remodeling and elevated secretory ability of metalloproteinase (MMPs) such as MMP-2. By doing so, it will create an intercellular space for the invasion of ...
Li Bo B Department of Mechanical Engineering, Biomedical Engineering and Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University, Baltimore, - - 2014
Cell migration plays a pivotal role in many physiologically important processes such as embryogenesis, wound-healing, immune defense, and cancer metastasis. Although much effort has been directed toward motility of individual cells, the mechanisms underpinning collective cell migration remain poorly understood. Here we develop a collective motility model that incorporates cell ...
Shin Yeon-Kyun YK Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address: - - 2014
The helical protein MLKL inserts into cell membranes and forms a permeation pore therein, resulting in cell death. In this issue of Structure, the article by Su and colleagues reports that helix 6 regulates the opening of the pore formed by preceding core helices.
Zhang Jiwei J Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214062, China. Contributed equally to this - - 2014
The expression of miR-638 was found downregulated in colorectal carcinoma (CRC) in our previous study. However, the role of miR-638 in CRC remains unknown. The aim of this study was to determine the function and mechanism of miR-638 in CRC. Here, we verified that miR-638 was frequently downregulated in CRC ...
Liu Hongxu H Department of Thoracic Surgery, The First Hospital, China Medical University, Shenyang 110001, China. Electronic address: - - 2014
SCIN (scinderin) is a calcium-dependent actin severing and capping protein. Homologue in zebrafish has been found to be related with cell death. In the present study, we found that SCIN is highly expressed in human lung cancer specimens. However, the role of SCIN in lung cancer has not yet been ...
Rosendahl Ann H AH Lund University, Department of Clinical Sciences Lund, Division of Surgery, Lund, Sweden; Lund University and Skåne University Hospital, Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund, Sweden. Electronic address: - - 2014
Pancreatic stellate cells (PSCs) play a key role in the dense desmoplastic stroma associated with pancreatic ductal adenocarcinoma. Studies on human PSCs have been minimal due to difficulty in maintaining primary PSC in culture. We have generated the first conditionally immortalized human non-tumor (NPSC) and tumor-derived (TPSC) pancreatic stellate cells ...
Li Bo B College of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA; Department of Tea Science, Zhejiang University, Hangzhou 310058, - - 2014
Adverse side effects and acquired resistance to conventional platinum based chemotherapy have become major impediments in ovarian cancer treatment, and drive the development of more selective anticancer drugs. Chaetoglobosin K (ChK) was shown to have a more potent growth inhibitory effect than cisplatin on two cisplatin-resistant ovarian cancer cell lines, ...
Ni Chao C Cancer Institute(Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Department of General surgery, Zhejiang Provincial People's Hospital, - - 2014
Increasing evidence showed invariant NKT cells (iNKT cell) are an attractive candidate for cancer immunotherapy, but its role in colorectal cancer treatment was still unclear. Here we reported iNKT cells exerted moderate cytotoxic effect against colorectal cancer cells (CRC cells) with the stimulation of α-Galcer, and the mutual recognition between ...
Cho Jin Hyoung JH Department of Oral Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 plus, Chonbuk National University, Jeonju 651-756, Republic of - - 2014
Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamous cell carcinoma (OSCC) cell ...
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