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Zahmatkesh Mona Haddad - - 2014
Ionizing radiation is the more effective therapy to reduce tumor growth through damaging the DNA of cells. In response to DNA damage, cells activate the checkpoint kinases such as CHK2, which signal to initiate repair processes and cell-cycle arrest, until the damaged DNA is repaired. At present, the development of ...
Wang Da-Hu DH Department of Dermatology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. - - 2014
The aim of the present study was to investigate the role of EphA2 in the carcinogenesis and progression of gastric carcinoma. Moreover, we aimed to determine the effect of geldanamycin (GA), an inhibitor of Hsp90, on the proliferation and apoptosis of human gastric carcinoma cells. Gastric carcinoma tissues, paired adjacent ...
Gong Xin X Department of Reproductive Endocrinology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, P.R. - - 2014
Uterine natural killer (uNK) cells are recruited into the uterus during establishment of the implantation and placentation of the embryo, and are hypothesized to regulate uterine spiral artery remodeling and angiogenesis during the initial stages of pregnancy. Failures in uNK cell activation are linked to diseases associated with pregnancy. However, ...
Slastnikova Tatiana A - - 2014
The review is devoted to a subcellular drug delivery system, modular nanotransporters (MNT) that can penetrate into target cells and deliver a therapeutic into their subcellular compartments, particularly into the nucleus. The therapeutics which need such type of delivery belong to two groups: (i) those that exert their effect only ...
Ampollini Luca L Thoracic Surgery, Department of Surgical Science, University Hospital of Parma, Parma, Italy - - 2014
The aim of the present study was to characterize the biological properties and in vivo tumourigenic potential of mesenchymal cells (MCs) obtained from non-small-cell lung cancer (NSCLC) samples. NSCLC samples (53 adenocarcinomas and 24 squamous-cell carcinomas) surgically removed from 46 males and 31 females were processed to identify mesenchymal cells ...
O'Leary Conor J CJ The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, 4072, - - 2014
A comprehensive understanding of adult neurogenesis is essential for the development of effective strategies to enhance endogenous neurogenesis in the damaged brain. Olfactory interneurons arise throughout life from stem cells residing in the subventricular zone of the lateral ventricle. Neural precursors then migrate along the rostral migratory stream (RMS) to ...
Jord Adel Al AA 1] Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, F-75005 Paris, France [2] Inserm, U1024, F-75005 Paris, France [3] CNRS, UMR 8197, F-75005 Paris, - - 2014
The semi-conservative centrosome duplication in cycling cells gives rise to a centrosome composed of a mother and a newly formed daughter centriole. Both centrioles are regarded as equivalent in their ability to form new centrioles and their symmetric duplication is crucial for cell division homeostasis. Multiciliated cells do not use ...
Li Hong-Wei HW Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, The Fourth Military Medical University, Xi'an, 710032, - - 2014
HAb18G/CD147 belongs to the immunoglobulin superfamily and predominantly functions as an inducer of matrix metalloproteinase secretion for tumor invasion and metastasis. This study was designed to investigate the effects of HAb18G/CD147 knockout on hepatocellular carcinoma cells using zinc-finger nuclease (ZFNs)-targeted gene knockout approach. The HCC cell line SMMC-7721 was used ...
Yang Yuan Y Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Department of Health Statistics, Second Military Medical University, Shanghai, China; National Innovation Alliance for Hepatitis & Liver Cancer, Shanghai, - - 2014
Pioglitazone (PGZ), a synthetic PPARγ ligand, is known to have anti-tumor activity. However, it is unclear how it acts against hepatocellular carcinoma (HCC). We hypothesized that the pathological receptor for advanced glycation end products (RAGE) is involved in the PGZ anti-tumor process. To test this notion, human primary HCC tissues ...
Ginisty Aurélie A University of Poitiers, CNRS ERL 7368, Signalisation et Transports Ioniques Membranaires, 86073, Poitiers , cedex, 09, - - 2014
Neural stem cells, whose major reservoir in the adult mammalian brain is the subventricular zone (SVZ), ensure neuropoiesis, a process during which many generated cells die. Removal of dead cells and debris by phagocytes is necessary for tissue homeostasis. Using confocal and electron microscopy, we demonstrate that cultured SVZ cells ...
Martello Graziano G Wellcome Trust-Medical Research Council Stem Cell Institute - - 2014
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture but can reenter embryonic development seamlessly, differentiating on schedule to form all elements of the fetus. Here we review the properties of these remarkable ...
Vrhovac Ivana I Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, - - 2014
Novel affinity-purified antibodies against human SGLT1 (hSGLT1) and SGLT2 (hSGLT2) were used to localize hSGLT2 in human kidney and hSGLT1 in human kidney, small intestine, liver, lung, and heart. The renal locations of both transporters largely resembled those in rats and mice; hSGLT2 and SGLT1 were localized to the brush ...
Kumar Sanjay - - 2014
Abstract The p53 tumor suppressor protein has been implicated as an activator of apoptosis. In order to investigate the effect of chelerythrine and staurosporine on the activation of p53-dependent/-independent pathways of DL cells death, cells were treated with chelerythrine and staurosporine for 1hr, 3hr and 6hr respectively. It was found ...
Chen Hsu-Hsin HH Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, - - 2014
The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers robust biochemical analysis of the processes that underlie early germ cell formation. Here, we demonstrate that DAZL, a germ cell-specific RNA binding protein, is a robust PGC marker during in vitro germ cell development. Using Dazl-GFP reporter ESCs, ...
Obchoei Sumalee S Department of Biochemistry, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, - - 2014
Cyclophilin A (CypA) was shown to be upregulated in human cholangiocarcinoma (CCA) tissues. Suppression of intracellular CypA (inCypA) significantly reduces cell proliferation in vitro and tumor growth in nude mice. In the present study, the effect and potential mechanism of secreted CypA (sCypA) on cell proliferation of CCA cell lines ...
Joniova Jaroslava J Department of Biophysics, Faculty of Science, University of Pavol Jozef Safarik, Jesenna 5, 041 54, Kosice, Slovak - - 2014
In order to explain the contribution of the protein kinase Cα (PKCα) in apoptosis induced by photo-activation of hypericin (Hyp), a small interfering RNA was used for post-transcriptional silencing of pkcα gene expression. We have evaluated the influence of Hyp photo-activation on cell death in non-transfected and transfected (PKCα(-)) human ...
Panneck Alexandra Regina AR Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385, Giessen, - - 2014
Specialized epithelial cells with a tuft of apical microvilli ("brush cells") sense luminal content and initiate protective reflexes in response to potentially harmful substances. They utilize the canonical taste transduction cascade to detect "bitter" substances such as bacterial quorum-sensing molecules. In the respiratory tract, most of these cells are cholinergic ...
Veigel Daniel D Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Vienna, Austria; Comprehensive Cancer Center, Medical University Vienna, Vienna, - - 2014
Ovarian cancer (OC) is caused by genetic aberrations in networks that control growth and survival. Importantly, aberrant cancer metabolism interacts with oncogenic signaling providing additional drug targets. Tumors overexpress the lipogenic enzyme fatty acid synthase (FASN) and are inhibited by FASN-blockers, whereas normal cells are FASN-negative and FASN-inhibitor-resistant. Here we ...
Burton Adam A Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM U964, Université de Strasbourg, F-67404 ILLKIRCH, Cité Universitaire de Strasbourg, - - 2014
Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a totipotent state. How embryonic cells subsequently acquire their fate and the role of chromatin dynamics in this process are unknown. Genetic and experimental embryology approaches have identified some of the players and morphological changes that are involved in ...
Zhao Jinjin J School of Materials Science and Engineering, Shijiazhuang Tiedao University, 17 Northeast, Second Inner Ring, Shijiazhuang, 050043, China. - - 2014
CuIn0.7Ga0.3S2 quantum dots (QDs) with particle size of 2-5 nm were directly synthesised by a vacuum one-pot-nanocasting process and homogeneously anchored on TiO2 nanocrystals (<50 nm) for the first time. We further present CuIn0.7Ga0.3S2 quantum dots and dye bilayer-sensitized solar cells with a power conversion efficiency 36.3% higher than mono-dye ...
Matos Juliana L JL Department of Biology, Stanford University, Stanford, United - - 2014
The presumed totipotency of plant cells leads to questions about how specific stem cell lineages and terminal fates could be established. In the Arabidopsis stomatal lineage, a transient self-renewing phase creates precursors that differentiate into one of two epidermal cell types, guard cells or pavement cells. We found that irreversible ...
Grossi Mario - - 2014
Much evidence highlights the importance of polyamines for vascular smooth muscle cell (VSMC) proliferation and migration. Caveolin-1 (Cav-1) was recently reported to regulate polyamine uptake in intestinal epithelial cells. The aim of the present study was to assess the importance of Cav-1 for VSMC polyamine uptake and its impact on ...
Shirakawa Makoto M Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, - - 2014
Brassicales plants, including Arabidopsis thaliana, have an ingenious two-compartment defense system, which sequesters myrosinase from the substrate glucosinolate and produces a toxic compound when cells are damaged by herbivores. Myrosinase is stored in vacuoles of idioblast myrosin cells. The molecular mechanism that regulates myrosin cell development remains elusive. Here, we ...
Murakami Yusuke Y Division of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; - - 2014
TLR3 senses viral dsRNA in endolysosomes. The TLR3 ectodomain is cleaved by proteases such as cathepsins in endolysosomes. It remains controversial whether the N-terminal fragment of TLR3 ectodomain (TLR3N) is cleaved off or remains associated with the C-terminal TLR3 fragment (TLR3C). In addition to endosomes, TLR3 is reported to be ...
Wang Xiao-Hu XH Medical School of Southeast University, Nanjing 210009, Jiangsu, - - 2014
Although tumor necrosis factor alpha (TNF-α) is known to play a critical role in intervertebral disc (IVD) degeneration, the effect of TNF-α on nucleus pulposus (NP) cells has not yet been elucidated. The aim of this study was to explore the effect of TNF-α on proliferation of human NP cells. ...
Yang Nai-Di ND National University of Singapore, - - 2014
Artesunate (ART) is an anti-malaria drug that has been shown to exhibit anti-tumor activity and functional lysosomes are reported to be required for ART-induced cancer cell death while the underlying molecular mechanisms remain largely elusive. In this study, we aimed to elucidate the molecular mechanisms underlying ART-induced cell death. We ...
da Silva Marcondes Daniela Beck DB Programa de Pós-graduação em Ciências Farmacêuticas. Universidade Federal do Paraná. Av. Lothário Meissner, 632. Jardim Botânico - 80210-170 - Curitiba - PR - Brazil. Electronic address: - - 2014
The stem barks of Lafoensia pacari have been traditionally used not only by South Amerindians but also by Brazilian and Paraguayan populations for treating a variety of unhealthy conditions to which their biological potential has been scientifically documented in several reports over the last decade. Although its anticancer usage is ...
Liang Xiao X The Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, - - 2014
Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells (TICs) is still problematic. This study investigated possibilities to isolate a population of cancer cells with tumour initiating properties based on their adherence ...
Wang Xing X Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. - - 2014
Ornithine decarboxylase antizyme 1 (OAZ1) is an antizyme targeting ornithine decarboxylase for degradation, subsequently inhibiting polyamine production to prevent cell proliferation. OAZ1 is also involved in other major cellular events, including differentiation and apoptosis. Recent studies have shown that OAZ1 has tumor suppressor activities and its effects on cell proliferation and ...
Zhang Chenjing C Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. - - 2014
The aim of the present study was to investigate the effect of cantharidin (CTD) on human gastric cancer cells and to explore the underlying mechanisms of these effects. The human gastric cancer SGC-7901 and BGC-823 cell lines were treated with CTD. MTS assays were then employed to examine cellular proliferation, ...
Ye Lan L Cancer Center, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
Radiotherapy is the main locoregional control modality for a number of types of malignant tumors, including glioblastoma. However, radiotherapy fails to prevent recurrence in numerous patients due to the intrinsic radioresistance of cancer cells. Cell senescence is significant in tumor suppressor mechanisms and is closely associated with the radioresistance of ...
Kawaguchi Tsukasa T Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, - - 2014
CD26 is a membrane glycoprotein that has multiple functions, including dipeptidyl peptidase IV activity. CD26 expression varies in different tumor types, and its role in tumor growth in hepatocellular carcinoma (HCC) remains unclear. CD26 expression levels were examined in resected HCCs and surrounding non-cancerous lesions. The effect of CD26 knockdown ...
Jin Jing J State Key Laboratory of Military Stomatology, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, People's Republic of - - 2014
Root resorption during orthodontic treatment is a complex and sterile inflammatory process, which is characterized by the recruitment of mononuclear cells in the local periodontal ligament. This study aimed to investigate whether interleukin (IL)-1β could induce the migration of monocytes through upregulating monocyte chemoattractant protein (MCP)-1 expression in human periodontal ...
Kilinc Devrim D UCD Nanomedicine Centre, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, - - 2014
Multifunctional nanoparticles that actively target-specific tissues are studied for cancer diagnosis and treatment. Magnetically and optically active particles are of particular interest because they enable multiple imaging modalities and physically modulated therapies, such as magnetic hyperthermia. Fe-Au nanorods are synthesized that have a long iron segment, coated with polyethylene glycol, ...
Oka Hiroko H Department of International Collaboration Development for Dentistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku Hiroshima, 734-8553, - - 2014
Background: F-spondin, known as a secreted neuronal glycoprotein, is highly expressed on the tooth root surface and we had reported F-spondin is one of the specific markers of cementoblasts in periodontal tissue. In chronic periodontitis, significant cemental resorption rarely occurs on the root side, although alveolar bone resorption by osteoclasts ...
Fülbier Angela - - 2014
Adipose-derived stroma cells (ASCs) are attractive cells for cell-based gene therapy but are generally difficult to transfect. Nucleofection has proven to be an efficient method for transfection of primary cells. Therefore, we used this technique to transfect ASCs with a vector encoding for Ambystoma mexicanum epidermal lipoxygenase (AmbLOXe) which is ...
Xiong Fengzhu F Department of Systems Biology, Harvard Medical School, Boston, MA 02115, - - 2014
Epithelial cells acquire functionally important shapes (e.g., squamous, cuboidal, columnar) during development. Here, we combine theory, quantitative imaging, and perturbations to analyze how tissue geometry, cell divisions, and mechanics interact to shape the presumptive enveloping layer (pre-EVL) on the zebrafish embryonic surface. We find that, under geometrical constraints, pre-EVL flattening ...
Buszczak Michael M Department of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, - - 2014
Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.
Tegha-Dunghu Justus - - 2014
Understanding the molecular basis for proper cell division requires a detailed functional analysis of microtubule (MT) associated proteins. MT associated protein 1S (MAP1S), the most ubiquitously expressed MAP1 family member, is required for accurate cell division. Using quantitative analysis of MT plus end tracking we show here that MAP1S knockdown ...
Long Xin Hua XH Department of Orthopedics, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. - - 2014
Pirarubicin is frequently used in chemotherapy against tumors. However, clinical use is severely limited by the development of progressive dose-dependent cardiomyopathy and acquired drug resistance. LY294002 is a commonly used pharmacologic inhibitor, which selectively inhibits the phosphoinositide 3-kinase-AKT nexus. The aim of this study was to investigate the combined inhibitory ...
Romano Nicole H NH Materials Science and Engineering Department, Stanford University, Stanford, CA 94305, USA. Electronic address: - - 2014
The innate biological response to peripheral nerve injury involves a complex interplay of multiple molecular cues to guide neurites across the injury gap. Many current strategies to stimulate regeneration take inspiration from this biological response, however, little is known about the balance of cell-matrix and Schwann cell-neurite dynamics required for ...
Salvador-Membreve Daile Meek C DM Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101, - - 2014
Trichomonas vaginalis, the causative agent of trichomoniasis is generally known to inhabit the genitourinary tract. However, several case reports with supporting molecular and immunological identifications have documented its occurrence in the respiratory tract of neonates and adults. In addition, the reports have documented that its occurrence is associated with respiratory ...
Jiang Qiying Q Department of Immunology, Basic Medical College of Zhengzhou University, Zhengzhou, Henan 450052, P.R. - - 2014
Heat shock factor 1 (HSF1), a main regulator of the heat shock response in eukaryotes, increases cell survival in numerous pathophysiological conditions. The aim of the present study was to o bserve the function of defective HSF1 expression in HEK293T cells. shRNA of human HSF1 was constructed into the retroviral vector ...
Jakab Martin M Institute of Physiology and Pathophysiology, Laboratory of Functional and Molecular Membrane Physiology, Paracelsus Medical University Salzburg, Salzburg, - - 2014
Background/Aims: The ATP12A gene codes for a non-gastric H(+)/K(+) ATPase, which is expressed in a wide variety of tissues. The aim of this study was to test for the molecular and functional expression of the non-gastric H(+)/K(+) ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 ...
Orchard-Webb David J - - 2014
Deregulated expression of the transmembrane glycoprotein CDCP1 (CUB domain-containing protein-1) has been detected in several cancers including colon, lung, gastric, breast, and pancreatic carcinomas. CDCP1 has been proposed to either positively or negatively regulate tumour metastasis. In this study we assessed the role of CDCP1 in properties of cells that ...
Ni Sujie S Department of Medical Oncology, Shanghai Cancer Center, Fudan University, No. 270 Dong An Road, Shanghai, 200032, - - 2014
NF45 (also known as ILF2), as one subunit of NF-AT (nuclear factor of activated T cells), repairs DNA breaks, inhibits viral replication, and also functions as a negative regulator in the microRNA processing pathway in combination with NF90. Recently, it was found that implicated in the mitotic control of HeLa ...
Feist Richard M RM Jr Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, 35294, - - 2014
The aim of this work is to evaluate the abundance, origins, and phenotypes of actively proliferating cells in proliferative diabetic retinopathy (PDR). Eleven epiretinal membranes from patients undergoing surgery for PDR were evaluated by indirect immunofluorescence for evidence of cell proliferation using the nuclear cell proliferation marker Ki67 and for ...
Wang Juan J Department of Pathology, The Second Hospital of Hebei Medical University, No. 215, Heping Western Road, Shijiazhuang, Hebei Province, People's Republic of - - 2014
Sterigmatocystin (ST), a mycotoxin commonly found in food and feed commodities, has been classified as a "possible human carcinogen." Our previous studies suggested that ST exposure might be a risk factor for esophageal cancer and that ST may induce DNA damage and G2 phase arrest in immortalized human esophageal epithelial ...
Ziegler Elke E Department of Gynecology and Obstetrics, Georg-August-University, Robert-Koch-Street 40, 37075, Göttingen, - - 2014
Epithelial-mesenchymal transition (EMT) is a cellular development program characterized by loss of cell adhesion and increased cell mobility. It is essential for numerous processes including metastasis. In this study we have generated "aggressive" MCF-7 breast cancer cells (MCF-7-EMT), which show significantly increased invasion in contrast to wild type MCF-7 (MCF-7 ...
Gegg Moritz M Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Munich, - - 2014
Planar cell polarity (PCP) regulates basal body (BB) docking and positioning during cilia formation, but the underlying mechanisms remain elusive. Here, we investigate the uncharacterized gene Flattop (Fltp) that is transcriptionally activated during PCP acquisition in ciliated tissues. Fltp knock-out mice show BB docking and ciliogenesis defects in multiciliated lung ...
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