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Jadali Zohre Z Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis.A systematic review of ...
- - 2014
Cover: Micrograph showing LNCaP cells transfected with miR-663. See article by Jiao et al. on pages 834-844.
Robertson D S DS Malvern, Worcestershire, United - - 2014
The origins of the characteristics associated with cells from both benign and malignant (cancer) tumors are proposed. It is shown that these deviant cells can originate as the result of the failure of the normal biochemical control of the formation of DNA and RNA. This change in characteristics is proposed ...
Jalalvand Elham E Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, SE-171 77, Stockholm, - - 2014
Cerebrospinal fluid-contacting (CSF-c) cells are found in all vertebrates, but their function remains elusive. In the lamprey spinal cord, they surround the central canal and some have processes passing the gray matter to the lateral edge of the flattened spinal cord. Stimulation of CSF-c cells at the central canal elicits ...
Khurelbaatar Zagarzusem - - 2014
We demonstrate locally contacted PEDOT:PSS Schottky diodes with excellent rectifying behavior, fabricated on n-type Si substrates using a spin-coating process and a reactive-ion etching process. Electrical transport characterizations of these Schottky diodes were investigated by both current-voltage (I-V) and capacitance-voltage (C-V) measurements. We found that these devices exhibit excellent modulation ...
Hasan Murtaza - - 2014
In this study, we report the cellular uptake studies of novel LX loaded nanoliposomes in H2O2 stress SH-SY5Y Cells synthesized by thin film evaporation method. We have isolated the smallest size nanoliposomes after 90 min ultrasonification, keeping Polydisperse Index as 0.259. The morphology, size, zepta potential and drug efficiency of ...
Wang Congzhou C Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, - - 2014
Probing the interaction forces that drive biomolecular recognition on cell surfaces is essential for understanding diverse biological processes. Force spectroscopy has been a widely used dynamic analytical technique, allowing measurement of such interactions at the molecular and cellular level. The capabilities of working under near physiological environments, combined with excellent ...
Eibel Hermann H Center for Chronic Immunodeficiency, University Medical Center Freiburg, Engesserstr. 4, Freiburg, 79108, Germany, - - 2014
In this review we summarize recent insights into the development of human B cells primarily by studying immunodeficiencies. Development and differentiation of B cells can be considered as a paradigm for many other developmental processes in cell biology. However, it differs from the development of many other cell types by ...
Dammeyer Pascal P Division of Biochemistry, Department of Medical Biochemistry and - - 2014
Abstract Conclusion: Inhibition of thioredoxin reductase (TrxR) may be a contributing factor in cisplatin-induced ototoxicity. Direct exposure of organ of Corti to cisplatin and oxaliplatin gives equal loss of hair cells. Objectives: Platinum-containing drugs are known to target the anti-oxidant selenoprotein TrxR in cancer cells. Two such anti-cancer, platinum-containing drugs, ...
He Huiying H *Department of Pathology, Peking University, Health Science Center, Beijing, China †Department of Pathology, R.T. Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, - - 2014
Epithelial-to-mesenchymal transition (EMT) describes a phenotypical change induced in epithelial cells that lose their cell-cell basement membrane contacts and their structural polarity to become spindle-shaped and morphologically similar to mesenchymal/myofibroblast cell. The abnormal induction of EMT has been demonstrated to contribute to cancer dissemination and progression. Renal cell carcinoma (RCC) ...
Karabanovas Vitalijus - - 2014
The practical use of quantum dots (QD) as diagnostic, visualizing and therapeutic nano-agents depends on the understanding of fundamental mechanisms of their entrance and trafficking within cells. Here we show that CdSe/ZnS carboxylic-coated QD (COOH-QD) enter fibroblast cells via lipid raft/caveolin-mediated endocytosis, pass early sorting endosomes and accumulate in the ...
Alayoubi Alaadin - - 2014
The highly malignant +SA mouse mammary epithelial cells were used as the model cell line over the years to establish the anticancer activity of tocotrienols. Tocotrienols, however, have poor oral bioavailability and were therefore entrapped into parenteral nanoemulsions for parenteral administration. The objective of this work was to test whether ...
Kim Eunjoo - - 2014
Common 2-dimensional (2D) cell cultures do not adequately represent cell-cell and cell-matrix signaling and substantially different diffusion/transport pathways. To obtain tissue-mimic information on nanoparticle toxicity from in vitro cell tests, we used a 3-dimensional (3D) culture of human lung cells (A549) prepared with elastin-like peptides modified with an arginine-glycine-aspartate motif. ...
Kim Hyojung - - 2014
Current-Voltage (I-V) and Capacitance-Voltage (C-V) characteristics of crystalline silicon solar cells were obtained under UV exposure. The solar cell parameters degraded with increasing exposure time. For example, open-circuit voltage (V(oc)), short-circuit current (J(sc)), fill-factor (FF) and efficiency (eta) were degraded. In this study, solar cell did not degrade at the ...
Fan Xing - - 2014
Controlling the blend morphology is critical for achieving high power conversion efficiency in polymer/fullerene bulk heterojunction (BHJ) photovoltaic devices. As a simple and effective method to control morphology, adding processing additives has been widely applied in the organic BHJ solar cells. In this paper, we demonstrate that adding 1,8-diiodooctane as ...
Bertoli Filippo F Centre For BioNano Interactions (CBNI), School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, - - 2014
Nanoparticles in contact with cells and living organisms generate quite novel interactions at the interface between the nanoparticle surface and the surrounding biological environment. However, a detailed time resolved molecular level description of the evolving interactions as nanoparticles are internalized and trafficked within the cellular environment is still missing and ...
Wang Yiwen Y Department of Pharmacy, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. - - 2014
Drug resistance limits the clinical application of cisplatin, a widely used chemotherapeutic agent. Gap junction (GJ) is a channel that enhances cytotoxicity of certain chemotherapeutic agents. Baicalein is well known for its antitumor activity. This study investigated the effect of baicalein on cisplatin cytotoxicity and the relationship between this effect and ...
Chen Siying S Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Methotrexate (MTX), as a chemotherapeutic drug, is widely used in the therapy of several cancer types. The efficiency of drug treatment is compromised by the appearance of multidrug resistance (MDR), and the underlying molecular mechanisms remain incompletely understood. We investigated the mechanism of MDR in the MTX-induced breast cancer MCF-7 ...
Jung Eui-Man EM Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of - - 2014
An embryonic stem cell test (EST) has been developed to evaluate the embryotoxic potential of chemicals with an in vitro system. In the present study, novel methods to screen toxic chemicals during the developmental process were evaluated using undifferentiated human embryonic stem (hES) cells. By using surface marker antigens (SSEA-4, ...
Nagyova Miriam M Institute of Neurobiology, Slovak Academy of Sciences, Center of Excellence for Brain Research, Soltesovej 4-6, 04001, Kosice, Slovakia, - - 2014
Mesenchymal stem cells (MSCs) have generated a great deal of promise as a potential source of cells for cell-based therapies. Various labeling techniques have been developed to trace MSC survival, migration, and behavior in vitro or in vivo. In the present study, we labeled MSCs derived from rat bone marrow ...
Fu Peifen P Department of Breast Surgery Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. - - 2014
The aim of the present study was to investigate the effects of tanshinone IIA (Tan IIA), an active constituent of Salvia miltiorrhiza Bunge, on epithelial-mesenchymal transition (EMT) and hypoxia-induced chemoresistance in breast cancer cells. To induce hypoxia, MCF-7 and HCC1973 cells were treated with 100 µM deferoxamine followed by doxorubicin (DOX). Cell viability and proliferation were ...
Aharon Sigalit S The Hebrew University of Jerusalem, Institute of Chemistry, Casali Center for Applied Chemistry, Israel. - - 2014
The inorganic-organic perovskite is currently attracting a lot of attention due to its use as a light harvester in solar cells. The large absorption coefficients, high carrier mobility and good stability of organo-lead halide perovskites present good potential for their use as light harvesters in mesoscopic heterojunction solar cells. This ...
Lassen Amanda - - 2014
The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. Anti-tumor effects of the combination ...
Shen Pengliang P Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, P.R., - - 2014
Kruppel-like factors (KLFs) are involved in various biological processes; emerging studies have indicated that KLF9 plays a critical role in regulating tumorigenesis. The role of KLF9 in prostate cancer (PCa), however, has not yet been investigated. The expression of KLF members, AKT- and apoptosis-related proteins were analyzed by Western blot ...
Pócza Tímea T 2nd Department of Pediatrics, Semmelweis University, Tűzoltó utca 7-9, H-1094, Budapest, - - 2014
As mammalian Target of Rapamycin (mTOR) plays role in protein synthesis and metabolism, mTOR pathway activation is involved in the pathogenesis of several types of tumors. Our aim was to elucidate its role in medulloblastoma in terms of prognosis and as a therapeutic target. Members of activated mTOR complex 1 ...
Van Khang Pham P a Shanghai Key Laboratory of New Drug Design , School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237 , P.R. - - 2014
Three new cardenolides (1-3) were isolated from the 90% ethanolic extract of the bark of a wild-type Calotropis gigantea. Their structures were determined by using NMR spectra and LC-MS analysis. Their inhibitory activities were evaluated against non-small cell lung carcinoma (A549) and human cervix epithelial adenocarcinoma (HeLa) cell lines. Compounds ...
Cheng Yunhui Y School of Chemistry and Biology Engineering, Changsha University of Science & Technology, Changsha, 410114, China, - - 2014
RVF (Arg-Val-Phe), a peptide derived from wheat germ, shows antioxidant properties. Here, the neuroprotective efficacies of RVF were investigated in human neuroblastoma cells (SH-SY5Y) that were pretreated with RVF (150-250 μM, 4 h) and exposed to H2O2 (200 μM). RVF increased viable cell numbers by 37 % and reduced the release of lactate dehydrogenase. ...
Horiguchi Kotaro K Laboratory of Anatomy and Cell Biology, Department of Health Sciences, Kyorin University, Tokyo, - - 2014
S100β-protein-positive cells in the anterior pituitary gland appear to possess multifunctional properties. Because of their pleiotropic features, S100β-positive cells are assumed to be of a heterogeneous or even a non-pituitary origin. The observation of various markers has allowed these cells to be classified into populations such as stem/progenitor cells, epithelial ...
Dilokpimol Adiphol A Department of Plant and Environmental Sciences; University of Copenhagen; Frederiksberg C, - - 2014
Arabinogalactan proteins are abundant cell-surface proteoglycans in plants and are involved in many cellular processes including somatic embryogenesis, cell-cell interactions, and cell elongation. We reported a glucuronosyltransferase encoded by Arabidopsis AtGlcAT14A, which catalyzes an addition of glucuronic acid residues to β-1,3- and β-1,6-linked galactans of arabinogalactan (Knoch et al. 2013). ...
Wilber Aaron A AA Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada T1K - - 2014
Navigation requires coordination of egocentric and allocentric spatial reference frames and may involve vectorial computations relative to landmarks. Creation of a representation of target heading relative to landmarks could be accomplished from neurons that encode the conjunction of egocentric landmark bearings with allocentric head direction. Landmark vector representations could then ...
Schuerch David - - 2014
Many advances have been made in recent years in cell culture models of the epithelial barrier of the lung from simple monolayers to complex 3-D systems employing different cell types. However, the vast majority of these models still present a static air-liquid interface which is unrealistic given the dynamic nature ...
Khoshgard Karim K Department of Medical Physics, Tarbiat Modares University, Tehran, - - 2014
Due to the high atomic number of gold nanoparticles (GNPs), they are known as new radiosensitizer agents for enhancing the efficiency of superficial radiotherapy techniques by increasing the dose absorbed in tumor cells wherein they can be accumulated selectively. The aim of this study was to compare the effect of ...
Beneyton Thomas T Laboratoire de Biologie Chimique, Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, 8 allée Gaspard Monge, F-67083 Strasbourg, - - 2014
We present a high-throughput droplet-based microfluidic analysis/screening platform for directed evolution of CotA laccase: droplet-based microfluidic modules were combined to develop an efficient system that allows cell detection and sorting based on the enzymatic activity. This platform was run on two different operating modes: the "analysis" mode allowing the analysis ...
Hou Yan-Jun YJ College of Animal Science and Technology, Nanjing Agriculture University, Nanjing, 210095, - - 2014
Zearalenone (ZEN) is a metabolite of Fusarium and is a common contaminant of grains and foodstuffs. ZEN acts as a xenoestrogen and is considered to be cytotoxic, tissue toxic, and genotoxic, which causes abortions and stillbirths in humans and animals. Since estrogens affect oocyte maturation during meiosis, in this study ...
Pitchai Daisy D Holy Cross College, PG & Research Department of Biotechnology, Trichy, Tamil Nadu, - - 2014
Costunolide, a sesquiterpene lactone is a plant-derived secondary metabolite found to be present in most of the pharmacologically active herbs, being the cause for their medicinal values. The present study aims to evaluate the cytotoxic effect of costunolide isolated from Costus speciosus rhizome extract on MDA-MB-231 cells and explore its ...
Gomillion Cheryl T CT Center for Biomaterials, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, - - 2014
End-capping by covalently binding functional groups to the ends of polymer chains offers potential advantages for tissue engineering scaffolds, but the ability of such polymers to influence cell behavior has not been studied. As a demonstration, polylactide (PLA) was end-capped with lithium carboxylate ionic groups (hPLA13kLi) and evaluated. Thin films ...
Segota Igor I Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, NY 14853, - - 2014
Unicellular eukaryotic amoebae Dictyostelium discoideum are generally believed to grow in their vegetative state as single cells until starvation, when their collective aspect emerges and they differentiate to form a multicellular slime mold. While major efforts continue to be aimed at their starvation-induced social aspect, our understanding of population dynamics ...
Shin Meong Cheol MC Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, MI, 48109, - - 2014
Protein toxins, such as gelonin, are highly desirable anti-cancer drug candidates due to their unparalleled potency and repetitive reaction mechanism in inhibiting protein translation. However, for its potential application in cancer therapy, there remains the cell membrane barrier that allows permeation of only small molecules, which must be overcome. To ...
Lai Min M Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States; College of Bioengineering, Chongqing University, Chongqing, China; College of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu Province, - - 2014
Surface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that osteoblast differentiation on microtextured titanium substrates is dependent on alpha-2 beta-1 (α2β1) integrin signaling. This study used focused ion beam (FIB) milling and scanning electron microscopy (SEM), combined with 3D image reconstruction, to ...
Fridman Yulia Y Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, - - 2014
Coherent plant growth requires spatial integration of hormonal pathways and cell wall remodeling activities. However, the mechanisms governing sensitivity to hormones and how cell wall structure integrates with hormonal effects are poorly understood. We found that coordination between two types of epidermal root cells, hair and nonhair cells, establishes root ...
Ledoux Quentin Q Département Valorisation des Productions Agricoles; Centre Wallon de Recherches Agronomiques; Gembloux, Belgium; Laboratoire de Chimie Organique et Médicinale; Université Catholique de Louvain; Louvain-la-Neuve, - - 2014
H 2O 2 acts as an important signaling molecule during plant/pathogen interactions but its study remains a challenge due to the current shortcomings in H 2O 2-responsive probes. In this work, ContPY1, a new molecular probe developed to specifically detect H 2O 2 was used to study the elicitation of ...
Corbin Elise A - - 2014
Micro-electromechanical systems (MEMS) resonant sensors provide a high degree of accuracy for measuring the physical properties of chemical and biological samples. These sensors enable the investigation of cellular mass and growth rate, though previous sensor designs have been limited to the study of homogeneous cell populations. Population heterogeneity, as is ...
Surguchenko Valentina A VA Laboratory of Tissue Engineering and Delivery Systems, Department of Biomedical Technologies and Tissue Engineering, Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Shchukinskaya 1, Moscow, Russia, 123182; Institute of Biomedical Research and Technology (ANO), B.Tishinsky, 43/20, building 2, Moscow, Russia, - - 2014
The study results of in vitro formation of tissue-engineered cartilage construct on the basis of cell-engineered construct composed of biopolymer hydrogel matrix and human adipose tissue-derived mesenchymal stromal cells (hADSCs) are presented. It was revealed that hADSCs in biopolymer hydrogel matrix Sphero®GEL under chondrogenic conditions generate three-dimensional structures and produce ...
Kami Daisuke D Department of Regenerative Medicine; Kyoto Prefectural University of Medicine; Kyoto, - - 2014
Epigenetic interventions are required to induce reprogramming from one cell type to another. At present, various cellular reprogramming methods such as somatic cell nuclear transfer, cell fusion, and direct reprogramming using transcription factors have been reported. In particular, direct reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) has ...
Qin Xiaodong - - 2014
PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires cell signaling pathways in these "PKM2 knockdown resistant" cells, and whether the rewired pathways are needed for ...
Cho S I SI Department of Otolaryngology-Head and Neck Surgery, Chosun University School of Medicine, Gwangju, South - - 2014
Objective: Ototoxicity due to cisplatin therapy interferes with treatment and often forces a reduction in the dosage, duration and frequency of the cisplatin therapy. (-)-Epigallocatechin-3-gallate is known to have the highest antioxidant potency among all tea catechins. This study aimed to investigate the effect of (-)-epigallocatechin-3-gallate on cisplatin ototoxicity in ...
Wu Deyao D Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng, Jiangsu 224001, P.R. - - 2014
microRNA‑145 (miR‑145) has been reported to be frequently downregulated in various types of cancer, including renal, prostate, bladder, lung and colon cancer, as well as B‑cell malignancies. The present study examined the effects of miR‑145 on the cell proliferation, migration and invasion of renal cell carcinoma (RCC). Following transfection of ...
Paleos Constantinos M CM National Center For Scientific Research "Demokritos" , 15310 Aghia Paraskevi, Attiki, - - 2014
Conspectus Researchers have become increasingly interested in the preparation and characterization of artificial cells based on amphiphilic molecules. In particular, artificial cells with multiple compartments are primitive mimics of the structure of eukaryotic cells. Endosymbiotic theory, widely accepted among biologists, states that eukaryotic cells arose from the assembly of prokaryotic ...
Bo Tao - - 2014
ε-Poly-L-Lysine (ε-PL), a naturally occurring amino-acid homopolymer, has been widely used as a food preservative. However, its antimicrobial mechanism has not been fully understood. In this study, we investigated the antimicrobial mode of action of ε-PL on a yeast Saccharomyces cerevisiae. When treated with ε-PL at the concentration of 500 ...
Lu Ko-Hsiu KH a Department of Orthopedics, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan and School of Medicine , Chung Shan Medical University , Taichung , - - 2014
Flavanones demonstrate a propensity to antiproliferation and induce apoptosis of malignant cells. Among the 4 flavanones under study, 2'-hydroxyflavanone exhibited the greatest potency to reduce the cell viability of 143 B cells in 4 osteosarcoma cells. Flow cytometry analysis showed that 2'-hydroxyflavanone increased the hypodiploid cells in the sub-G1 phase ...
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