Search Results
Results 1 - 50 of 29142
1 2 3 4 5 6 7 8 9 10 >
Chen Jing-Xiao JX School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR China; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR - - 2014
A novel micelle based on heparosan and deoxycholic acid (DOCA) conjugate (HD) as drug carrier was reported here. As the surface was negatively charged, this micelle could resist serum adsorption, showing favorable stability. Moreover, fluorescence observation confirmed that it was able to deliver model hydrophobic drug doxorubicin (DOX) into HeLa ...
Dobrzyński Maciej M http://orcid.org/0000-0002-0208-7758 Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland - - 2014
We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input-output characteristics (the dose-response curve) and variability in protein abundance. Large cell-to-cell variation in the nonlinear dose-response characteristics can be beneficial to facilitate two distinct groups of response levels ...
Zheng Shuyao S Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida College of Medicine, University of Florida, 1275 Center Dr, Room J597, Gainesville, FL, 32610-0275, - - 2014
Clinical onset of type 1 diabetes (T1D) is thought to result from a combination of overt beta cell loss and beta cell dysfunction. However, our understanding of how beta cell metabolic abnormalities arise during the pathogenesis of disease remains incomplete. Despite extensive research on the autoimmune nature of T1D, questions ...
Oróstica María L ML Laboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, ChileLaboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, - - 2014
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor (ER) with subsequent production of cAMP and inositol triphosphate (IP3). However, the role of the different oviductal cellular phenotypes on this ...
Freund Guillaume G Ecole Supérieure de Biotechnologie de Strasbourg, UMR 7242, CNRS/Université de Strasbourg, Boulevard Sébastien Brant, Illkirch, - - 2014
Intrabodies, when expressed in cells after genetic fusion to fluorescent proteins, are powerful tools to study endogenous protein dynamics inside cells. However, it remains challenging to determine the conditions for specific imaging and precise labelling of the target antigen with such intracellularly expressed antibody fragments. Here, we show that single-chain ...
Baker Richard M RM Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, - - 2014
Understanding single and collective cell motility in model environments is foundational to many current research efforts in biology and bioengineering. To elucidate subtle differences in cell behaviour despite cell-to-cell variability, we introduce an algorithm for tracking large numbers of cells for long time periods and present a set of physics-based ...
Abouchar Laurent L Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, - - 2014
Developmental processes in multicellular organisms occur in fluctuating environments and are prone to noise, yet they produce complex patterns with astonishing reproducibility. We measure the left-right and inter-individual precision of bilaterally symmetric fly wings across the natural range of genetic and environmental conditions and find that wing vein patterns are ...
Jadali Zohre Z Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis.A systematic review of ...
Jin Jin J Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. - - 2014
Murine P19 embryonal carcinoma cells are multipotent cells that can differentiate into cardiomyocytes when treated with dimethyl sulfoxide. This experimental model provides an invaluable tool to study different aspects of cardiac differentiation, such as the function of cardiac‑specific transcription factors and signaling pathways, and the regulation of contractile protein expression. ...
Feng Jihong J Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. - - 2014
Although human peroxiredoxin 2 (PRDX2) has been implicated in tumor progression (e.g., invasion and metastasis), little is known regarding its role in the epithelial‑mesenchymal transition (EMT) process during tumorigenesis. The present study offers the first evidence, to the best of our knowledge, that the antioxidant enzyme PRDX2 has an important ...
Luo Jinghua J Department of Radiotherapy, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. - - 2014
The aim of the present study was to investigate the effects of aloe-emodin (AE) on the radiosensitivity and differentiation of HeLa human cervical cancer cells. Cell proliferation was assessed in the HeLa cervical cancer cell line by a methylthiazolyldiphenyl-tetrazolium bromide assay. Radiosensitivity was determined by a colony‑forming assay. Flow cytometry ...
Dal-Pra Sophie S Division of Cardiology, Department of Medicine, Duke University Medical Center & Duke Cardiovascular Research Center, GSRBII, Room 4022, 210 Research Drive, Durham, NC, 27710, - - 2014
Reconstitution of cardiac muscle as well as blood vessels to provide sufficient oxygenation and nutrients to the myocardium is an important component of any therapeutic approach for cardiac repair after injury. Recent reports of reprogramming somatic cells directly to cells of another lineage raised the possibility of using cell reprogramming ...
Han Yu Y 1Department of Gastrointestinal Oncology 2Department of Chest Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China *these authors contributed equally to this - - 2014
Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cancer biology, and functional lncRNAs can be used for cancer diagnosis and prognosis. One lncRNA that has attracted significant attention is urothelial carcinoma-associated 1 (UCA1), which ...
Ohgami Robert S RS From Stanford University Medical Center, Stanford, CA. - - 2014
To characterize the clinicopathologic features of cases of large B-cell lymphomas, poor in B cells and densely rich in programmed cell death-1 (PD-1)+ reactive T cells, which can mimic T-cell lymphomas. A single-institute retrospective review of cases between 2010 and 2013 was performed. Of 178 cases of large B-cell lymphomas, ...
Zhu Bao-Song BS Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215021, P.R. - - 2014
The aim of this study was to investigate the effects of the adenoviral-mediated autophagy gene, damage-regulated autophagy regulator (DRAM), on the proliferation and autophagy of SGC7901 human gastric cancer cells in vitro. The recombinant adenovirus, AdMax-pDC315-DRAM-EGFP, working as a virus vector of DRAM was constructed and infected into the SGC7901 ...
Zhu Yalin Y Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. - - 2014
The aim of the present study was to investigate the effects of propranolol and isoproterenol on the growth curve of infantile hemangioma endothelial cells (IHECs) in vitro and determine the functions of the β-adrenergic receptor in the pathogenesis of infantile hemangioma. IHECs were divided into three groups: The control group, ...
Zhang Jing J Department of Clinical Medicine, Medical College of Yan'an University, Yan'an, Shaanxi 716000, P.R. - - 2014
The present study aimed to investigate the effect of the inhibition of miR-145 on cyclin-dependent protein kinase 6 (CDK6) and the proliferation of human cervical carcinoma cells. The miR-145 sequence was synthesized and cloned into pcDNA™6.2-GW to construct the recombinant plasmid pcDNA6.2-GW-miR-145. HeLa cells were divided into the micro (mi)R-145, ...
Shao Hongmin H Department of Oncology, Hospital of Traditional Chinese Medicine, Yantai, Shandong 264000, P.R. - - 2014
Triptolide is a diterpene triepoxide compound extracted from the medicinal plant, Tripterygium wilfordii Hook F. The aim of the present study was to determine whether triptolide inhibits the proliferation of breast cancer cells and to further investigate the associated molecular mechanisms. The effects of triptolide on the cell viability of ...
Choi Eun Jeong EJ Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Republic of - - 2014
The present study investigated the effect of the phytochemical genistein on the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of estrogen receptor-α (ERα) expression and the induction of apoptosis. When MCF-7 human breast cancer cells were treated with 50, 100, 150 and 200 μM genistein for ...
Ma Li L Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300050, P.R. - - 2014
AG1478 is a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. The effect of AG1478 on the A549/DDP (cisplatin-resistant human lung adenocarcinoma) cell line is unknown. The aim of the present study was to investigate the effects of AG1478 on the A549/DDP cell line and its sensitive parental A549 ...
Yang Yang Y Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. - - 2014
Saw palmetto extract can induce the apoptosis of prostate cancer cells. The aim of the present study was to investigate the effect of saw palmetto extract on the phosphatidylinositol 3-kinase (PI3K)/Akt signaling transduction pathway in human glioma U87 and U251 cell lines. Suspensions of U87 and U251 cells in a ...
Jin Gang G Department of Medical Imaging, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China ; The No. 211 Hospital of the People's Liberation Army, Harbin, Heilongjiang 150086, P.R. - - 2014
Protein O-glucosyltransferase 1 (POGLUT1) is a novel gene that was initially isolated and identified from the bone marrow cells of patients with myelodysplastic syndrome/acute myeloid leukemia. Previous findings have suggested that POGLUT1 promotes the proliferation of U937 human tissue lymphoma cells. Furthermore, POGLUT1 has been identified in other tissues, including ...
Li Yun Y Department of Respiratory Medicine, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, P.R. China ; Department of Respiratory Medicine, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, P.R. - - 2014
The aim of the present study was to investigate the potential role of microRNA (miRNA or miR) in invasion and metastasis of non-small cell lung cancer (NSCLC). miRNA-microarray analysis was used to detect the differentially expressed miRNAs between various metastatic levels of NSCLC cells. The microarray results were verified by ...
Zhang Dejun D Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. - - 2014
The aim of the present study was to investigate whether radiation induces the mammalian target of rapamycin (Rap) (mTOR) signaling pathway in esophageal carcinoma Eca109 cells, and whether mTOR inhibition by rapamycin increases Eca109 cell radiosensitivity. Changes in the levels of mTOR signaling pathway and DNA damage-repair proteins in Eca109 ...
Zhang Qiu-Yue QY Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China ; Pediatrics Intensive Care Units, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
The aim of the present study was to investigate water transport dysfunction in alveolar epithelial type II cells (AECII), which were exposed to hyperoxia, and to investigate the mechanism of pulmonary edema resulting from hyperoxic lung injury. The lung cells of newborn rats were isolated for primary cell culture and ...
Wang Wei W Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. - - 2014
This study aimed to investigate the lethal effect of the combination of bluetongue virus (BTV) and radiation on RM-1 murine prostate cancer cells in vitro and in vivo. Various cell lines were infected with BTV and the cytotoxicity was tested by a lactate dehydrogenase (LDH) release bioassay. Additionally, the RM-1 ...
Chen Zhangxing Z Department of Gastroenterology, The 174th Hospital of the PLA, Xiamen University, Xiamen, Fujian 361003, - - 2014
The role of LIM domain-containing protein 1 (LIMD1) in the multidrug resistance of colorectal carcinoma (CRC) has not yet been established. The aim of the current study was to investigate the chemosensitivity of CRC multidrug-resistant (MDR) cells following the silencing of LIMD1. The MDR phenotypic Colo205 and HCT-8 cell lines ...
Peng Zhengjun Z Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Guangdong Province Key Laboratory of Stomatology Guangzhou, Sun Yat-Sen University, Guangdong, - - 2014
During tooth development, the special structure of dental follicle and dental papilla enables dental papilla cells (DPCs) and dental follicle cells (DFCs) to make contact with each other. Octamer-binding transcription factor 4 (Oct-4), sex determining region Y box-2 (SOX-2), and cellular homologue of avian myelocytomatosis virus oncogene (MYC) (OSM) are associated ...
Uemura Yusuke Y Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., 20-1 Hirai, Hinode-machi, Tokyo, 190-0182, Japan, - - 2014
We have demonstrated that Bifidobacterium animalis subsp. lactis LKM512 had some probiotic properties in vivo and in vitro. To further understand their mechanisms, the chemical structure of the extracellular polysaccharide that constructs the cell envelope was determined. The strain was anaerobically cultured in MRS broth at 37 °C for 20 h, then ...
Song Yuxian Y The State Key Laboratory of Pharmaceutical Biotechnology; Division of Immunology; Medical School; Nanjing University; Nanjing, PR - - 2014
MicroRNAs (miRNAs) dysregulation is critically involved in lung cancer. Regulating miRNAs by natural agents may be a new strategy for cancer treatment. We previously found that a novel small-molecule compound diaporine A (D261), a natural product of endophytic fungus 3lp-10, had potential anti-cancer activites. In the present study, the inhibitory ...
Barazzuol L - - 2014
Abstract Purpose: Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we use a combination of two novel treatment modalities, carbon ions and a histone deacetylase inhibitor (HDACi). We compare these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitisation ...
Tsai Meng-Lin - - 2014
We realized photovoltaic operation in large-scale MoS2 monolayers by the formation of a type-II heterojunction with p-Si. The MoS2 monolayer introduces a built-in electric field near the interface between MoS2 and p-Si to help photo-generated carrier separation. Such a heterojunction photovoltaic device achieves a power conversion efficiency of 5.23%, which ...
Singh Ajay Vikram - - 2014
This study reports a facile biomineralization route to gold microplates (GMPs) synthesis using bovine serum albumin (BSA) as reductant and stabilizing agent. Adding BSA to HAuCl4 solution yields spontaneous versatile anisotropic and partially hollow GMPs upon ageing. We hypothesize that, the instantaneous protein denaturation at low pH enabled access to ...
Kolacsek Orsolya O Research Centre for Natural Sciences, HAS, Institute of Molecular Pharmacology, Budapest, Hungary ; - - 2014
The Sleeping Beauty (SB) and piggyBac (PB) DNA transposons represent an emerging new gene delivery technology, potentially suitable for human gene therapy applications. Previous studies pointed to important differences between these transposon systems, depending on the cell types examined and the methodologies applied. However, efficiencies cannot always be compared due ...
Wang W-T WT Molecular Oncology Unit, YCR/CRUK Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield School of Medicine, Sheffield, - - 2014
While DNA damage response pathways are well characterized in cancer cells, much less is known about their status in normal cells. These pathways protect tumour cells from DNA damage and replication stress and consequently present potential therapeutic targets. Here we characterize the response of human telomerase reverse transcriptase (hTERT)-immortalized normal ...
Reinke Emily N - - 2014
ABSTRACT The treatment of chronic myelogenous leukemia with specific tyrosine kinase inhibitors typically results in clinical success although therapeutic failure frequently occurs. In order to investigate the biological consequences of treating CML cells with such drugs, we previously reported that the anti-oxidant selenoprotein GPx-1 was induced by imatinib in both ...
Kanjilal Baishali B U.S. Army Research Institute of Chemical Defense, Pharmacology and Immunology, Gunpowder, United - - 2014
Abstract The US military has placed major emphasis on developing therapeutics against nerve agents. Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering new nerve agent ...
Zhang Xiu-Zhen XZ 1 School of Life Sciences, Shandong University of Technology , Zibo, China - - 2014
Abstract This study aims at evaluating the anticancer effects of berberine hydrochloride (berberine) and d-limonene, alone and in combination, on human gastric carcinoma cell line MGC803 to determine whether berberine and d-limonene work synergistically and elucidate their mechanisms. MGC803 cells were treated with berberine and d-limonene, alone and in combination, ...
García-Gómez Candela C Department of Ecology, Faculty of Sciences, University of Málaga, Bvd. Louis Pasteur s/n, 29010 Málaga, Spain. - - 2014
The effects of increased CO2 and irradiance on the physiological performance of the chlorophyte Dunaliella tertiolecta were studied at different PAR and UVR (UVA + UVB) irradiances, simulating the solar radiation at different depths, at present (390 ppmv, LC) and predicted CO2 levels for the year 2100 (1000 ppmv, HC). ...
MacKay Joanna L JL Department of Chemical and Biomolecular Engineering, University of California-Berkeley, Berkeley, California 94720, - - 2014
The GTPases RhoA and Rac1 are key regulators of cell spreading, adhesion, and migration, and they exert distinct effects on the actin cytoskeleton. While RhoA classically stimulates stress fiber assembly and contraction, Rac1 promotes branched actin polymerization and membrane protrusion. These competing influences are reinforced by antagonistic crosstalk between RhoA ...
Sun Jing J Department of Periodontology, School of Stomatology Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine, 44-1# West Wenhua Road, Jinan, 250012, Shandong, People's Republic of - - 2014
Periodontal ligament-associated protein-1 (PLAP-1) is a newly discovered member of the extracellular matrix family of proteins known as proteoglycans and is a negative regulator that plays a crucial role in the homeostasis of periodontal tissues. It can protect the periodontal ligament from excessive osteogenesis. However, the molecular mechanisms of PLAP-1 ...
Sehrawat Anuradha A Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Pittsburgh, PA, - - 2014
We showed previously that zerumbone (ZER), a sesquiterpene isolated from subtropical ginger, inhibited in vitro (MCF-7 and MDA-MB-231cells) and in vivo (MDA-MB-231 cells) growth of human breast cancer cells in association with apoptosis induction. Here, we investigated the role of Notch receptors in anticancer effects of ZER (cell migration inhibition ...
Li Bo B Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2014
Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is characterized by elevated glycogen levels and fat deposition. These consistent metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIFs) secondary to von Hippel-Lindau (VHL) mutations that occur in over 90% of ccRCC tumours. However, ...
Tang Qin Q 1] Molecular Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. - - 2014
Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund. Mutant fish engraft muscle, blood stem cells and various cancers. rag2(E450fs) ...
Zhang Ming M University of Toronto, - - 2014
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Due to their direct stimulation of insulin secretion from pancreatic beta cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of ...
Kuete Victor V Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128, Mainz, - - 2014
Introduction Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds. This work was designed to assess the cytotoxicity and the mechanism of action of flavonoids ...
Shen Liming L College of Life Science, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen, 518060, People's Republic of - - 2014
Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder disease developed in patients with underlying renal insufficiency following exposure to gadolinium-based contrast agents (GBCAs). Previous studies have demonstrated that GdCl3 can promote NIH3T3 fibroblast cell proliferation, which provide a new clue to the role of GBCAs in the development of NSF. ...
Ohashi Haruka H Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho Fuchu, Tokyo, 183-8509, Japan, - - 2014
Irreversible shifts in ecosystems caused by large herbivores are becoming widespread around the world. We analyzed data derived from the 2009-2010 Sika Deer Impact Survey, which assessed the geographical distribution of deer impacts on vegetation through a questionnaire, on a scale of 5-km grid-cells. Our aim was to identify areas ...
Lee Young Ho YH Division of Rheumatology, Department of Internal Medicine Korea University Anam Hospital, Korea University College of Medicine, 126-1 5 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea, - - 2014
The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and mechanisms of Alzheimer's disease (AD) and to generate SNP to gene to pathway hypotheses. An AD genome-wide association study (GWAS) dataset that included 370,542 SNPs in 1,000 cases and 1,000 controls of European descent was used ...
Jablonska Olga O University of Warmia and Mazury in Olsztyn Department of Zoology Oczapowskiego 1A 10-719 Olsztyn - - 2014
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a by-product of human industrial activity, was found to affect ovarian steroidogenesis in animals, but the mechanism of its action is still unclear. The aims of the study were to examine the effect of TCDD on (1) progesterone (P4) and oestradiol (E2) production by granulosa cells ...
1 2 3 4 5 6 7 8 9 10 >