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Brom Maarten M Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, The Netherlands - - 2014
Targeting of the Glucagon-like peptide 1 receptor with (111)In-labeled exendin is an attractive approach to determine the beta cell mass (BCM). Preclinical studies as well as a proof-of-concept study in type 1 diabetic patients and healthy subjects showed a direct correlation between BCM and radiotracer uptake. Despite these promising initial ...
Li Xiaodong - - 2014
Disodium edetate (EDTA-Na), a popular hexadentate ligand in analytical chemistry, was successfully introduced in organic solar cells (OSCs) as cathode interfacial layer. The inverted OSCs with EDTA-Na showed superior performance both in power conversion efficiency and devices stability compared with conventional devices. Interestingly, we found that the performance of devices ...
Walsh Noreen M NM Department of Pathology, Capital District Health Authority and Dalhousie University Halifax, NS, - - 2014
Hypertrophic discoid lupus erythematosus, a rare variant of lupus skin disease, can be difficult to distinguish from squamous neoplasms and certain dermatoses microscopically. Recognition, recently, of the pathogenetic significance of plasmacytoid dendritic cells in cutaneous lupus erythematosus, and of their patterns of distribution in different manifestations of the disease, prompted ...
Zhu Xiuzhen X Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, - - 2014
Electrophoresis and dielectrophoresis of cells can reveal many distinct cellular properties but are often conducted separately. Herein a simultaneous strategy was proposed, and a simple method was established by making cells migrate through a cross channel under a micro video for real-time observation. The experiment can be performed within 0.044-1s. ...
Ceko M J MJ School of Chemistry and Physics, The University of Adelaide, SA 5005, Australia. - - 2014
Studies of selenium (Se) status indicate that Se is necessary for fertility but how precisely is not known. We aimed to show that Se was important in bovine female reproductive function. The elemental distribution in the bovine ovary (n = 45 sections) was identified by X-ray fluorescence (XRF) imaging. Se ...
Pasirayi Godfrey G School of Science and Engineering, Teesside University, Borough Road, Middlesbrough TS1 3BA, United Kingdom. Electronic address: - - 2014
A reusable low cost microfluidic cell culture array device (MCCAD) integrated with a six output concentration gradient generator (cGG) and 4×6 arrays of microchamber elements, addressed by a series of row and columnar pneumatically actuated normally closed (NC) microvalves was fabricated for cell-based screening of chemotherapeutic compounds. The poly(dimethylsiloxane) (PDMS) ...
Gord Alexander A Center for Mathematical and Computational Biology, Department of Mathematics, University of California, Irvine, CA 92617, USA Center for Complex Biological Systems, University of California, Irvine, CA 92617, - - 2014
Skin is a complex organ tasked with, among other functions, protecting the body from the outside world. Its outermost protective layer, the epidermis, is comprised of multiple cell layers that are derived from a single-layered ectoderm during development. Using a new stochastic, multi-scale computational modelling framework, the anisotropic subcellular element ...
Ju Xiao-Min XM School of Biology and Basic Medical Sciences, Soochow University, 199 Ren-Ai Road, 215123, Suzhou, People's Republic of - - 2014
In this study, pullulan production was achieved by whole-cell bioconversion with Aureobasidium pullulans CCTCC M 2012259. Response surface methodology was applied to optimize the seed medium for incubating cells with high capability of pullulan bioconversion. Three medium components, namely, yeast extract, MgSO4·7H2O, and glucose were identified by Plackett-Berman design as ...
Wang Hao H Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou 310058, - - 2014
Cyanobacteria-derived toxin microcystin-LR (MCLR) has been widely investigated in its effects on normal cells, there is little information concerning its effects on cancer cells. In the present study, the SMMC-7721 human liver cancer cell line treated with MCLR was used to investigate the change of PP2A, cytoskeleton rearrangement, phosphorylation levels ...
Grasselli E E DISTAV, Dipartimento di Scienze della Terra, dell'Ambiente e della Vita, Università di Genova, Corso Europa 26, 16132 Genova, Italy; INBB, Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy. Electronic address: - - 2014
Tetrabromobisphenol A (2,2-bis(3,5-dibromo-4-hydroxyphenyl propane-TBBPA) is the most produced brominated flame retardant, detected in the environment and in biological samples. TBBPA shares structural similarities with thyroid hormones (THs), and it has been shown to interfere with different aspects of TH physiology, this raising concern on its possible effects as an endocrine ...
Llabjani Valon V Centre for Biophotonics, Lancaster University, Lancaster LA1 4YQ, UK; Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: - - 2014
Understanding how organisms respond to trace elements is important because some are essential for normal bodily homeostasis, but can additionally be toxic at high concentrations. The inflection point for many of these elements is unknown and requires sensitive techniques capable of detecting subtle cellular changes as well as cytotoxic alterations. ...
Mikulic Paulina P School of Biological Sciences, Monash University, Clayton, VIC 3800, Australia. Electronic address: - - 2014
This study aimed to determine the contrasting ecotoxicity effects of zinc on growth and photosynthesis in a neutrophilic (Chlamydomonas reinhardtii) and an extremophilic (Cyanidium caldarium) alga. Experiments were carried out to see if cells acclimated to zinc would respond differently to cells that were unexposed to zinc. The study also ...
Lopez-Camacho Cesar C Department of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine, Burlington, - - 2014
Core Binding Factor β (CBFβ) is complexed with the RUNX family of transcription factors in the nucleus to support activation or repression of genes related to bone (RUNX2), hematopoiesis (RUNX1) and gastrointestinal (RUNX3) development. Furthermore, RUNX proteins contribute to the onset and progression of different types of cancer. Although CBFβ ...
Wolkow Natalie N F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, 305 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, - - 2014
The purpose of our studies was to examine the relationship between iron and melanogenesis in retinal pigment epithelial cells, as prior observations had suggested that iron may promote melanogenesis. This relationship has potential clinical importance, as both iron overload and hyperpigmentation are associated with age-related macular degeneration (AMD). Human fetal ...
Salaroli Roberta R Department of Biomedical and Neuromotor Sciences, "Alma Mater Studiorum" University of Bologna, Via Massarenti 9, 40138, Bologna, - - 2014
Medulloblastomas (MBs) associated with the Wnt activation represent a subgroup with a favorable prognosis, but it remains unclear whether Wnt activation confers a less aggressive phenotype and/or enhances radiosensitivity. To investigate this issue, we evaluated the biological behavior of an MB cell line, UW228-1, stably transfected with human β-catenin cDNA ...
Li Mu M Thermo Fisher Scientific, Austin, TX 78744, - - 2014
Exosomes are tiny vesicles (30-150 nm) constantly secreted by all healthy and abnormal cells, and found in abundance in all body fluids. These vesicles, loaded with unique RNA and protein cargo, have a wide range of biological functions, including cell-to-cell communication and signalling. As such, exosomes hold tremendous potential as ...
Gilchrist Christopher L CL Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, - - 2014
Tissue and biomaterial microenvironments provide architectural cues that direct important cell behaviors including cell shape, alignment, migration, and resulting tissue formation. These architectural features may be presented to cells across multiple length scales, from nanometers to millimeters in size. In this study, we examined how architectural cues at two distinctly ...
Gupta Pranav P Morehouse School of Medicine, Atlanta, GA, - - 2014
Poor clinical outcome of lung cancer (LuCa) is primarily due to lack of knowledge about specific molecules involved in its progression and metastasis. In this study, we for the first time show the clinical and biological significance of CC chemokine receptor-9 (CCR9) in non-small cell lung cancer (NSCLC). Expression of ...
Chen Jing-Xiao JX School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR China; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR - - 2014
A novel micelle based on heparosan and deoxycholic acid (DOCA) conjugate (HD) as drug carrier was reported here. As the surface was negatively charged, this micelle could resist serum adsorption, showing favorable stability. Moreover, fluorescence observation confirmed that it was able to deliver model hydrophobic drug doxorubicin (DOX) into HeLa ...
Greunke Christian C Institute of Biochemistry and Molecular Biology, Rheinische Friedrich-Wilhelms-University of Bonn, Nussallee 11, D-53115 Bonn, - - 2014
The bronchospasmolytic and secretolytic effects of ivy leaves dry extracts can be explained by an increased β2-adrenergic responsiveness of the bronchi. Recently, it was shown that α-hederin inhibits the internalization of β2-adrenergic receptors (ß2AR) under stimulating conditions. α-Hederin pretreated alveolar type II cells and human airway smooth muscle cells revealed ...
Marschall Robert R Institut fuer Biologie und Biotechnologie der Pflanzen, Westf. Wilhelms-Universität Muenster, Hindenburgplatz 55, D-48143 Muenster, - - 2014
Reactive oxygen species (ROS) are produced in conserved cellular processes either as by-products of the cellular respiration in mitochondria, or purposefully for defense mechanisms, signaling cascades or cell homeostasis. ROS have two diametrically opposed attributes due to their highly damaging potential for DNA, lipids and other molecules and due to ...
Matsumae Yoshiharu Y Graduate School of Environmental Studies, Tohoku University, Aramaki 6-6-11-605, Aoba, Sendai 980-8579, - - 2014
We evaluated the intracellular NAD(P)H:quinone oxidoreductase (NQO) activity of single HeLa cells by using the menadione-ferrocyanide double-mediator system combined with scanning electrochemical microscopy (SECM). The double-mediator system was used to amplify the current response from the intracellular NQO activity and to reduce menadione-induced cell damage. The electron shuttle between the ...
Cui De-Xuan DX Pharmacy and Biological Science College, Weifang Medical University, Weifang, Shandong 261053, P.R. - - 2014
Aminopeptidase N (APN) is important in tumour processes. The present study detected the anti‑tumour activity of the novel APN inhibitor DH‑12a, which is an indoline‑2,3‑dione derivative. In the present study, Bestatin, a clinical APN inhibitor was used as a positive control. The expression of APN in the ES-2 and 3AO ...
Dobrzyński Maciej M http://orcid.org/0000-0002-0208-7758 Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland - - 2014
We show theoretically and experimentally a mechanism behind the emergence of wide or bimodal protein distributions in biochemical networks with nonlinear input-output characteristics (the dose-response curve) and variability in protein abundance. Large cell-to-cell variation in the nonlinear dose-response characteristics can be beneficial to facilitate two distinct groups of response levels ...
Chavali Pavithra L PL Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, - - 2014
The centrosome, a key microtubule organizing centre, is composed of centrioles, embedded in a protein-rich matrix. Centrosomes control the internal spatial organization of somatic cells, and as such contribute to cell division, cell polarity and migration. Upon exiting the cell cycle, most cell types in the human body convert their ...
Agircan Fikret G FG Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, - - 2014
The centrosome is the main microtubule (MT)-organizing centre of animal cells. It consists of two centrioles and a multi-layered proteinaceous structure that surrounds the centrioles, the so-called pericentriolar material. Centrosomes promote de novo assembly of MTs and thus play important roles in Golgi organization, cell polarity, cell motility and the ...
Fırat-Karalar Elif Nur EN Department of Biology, Stanford University, Stanford, CA 94305-5020, - - 2014
Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of ...
Sluder Greenfield G Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA - - 2014
This review discusses some of the history of the fundamental, but not fully solved problem of how the centrosome duplicates from one to only two as the cell prepares for mitosis. We start with some of the early descriptions of the centrosome and the remarkably prescient but then controversial inferences ...
Ishihara Keisuke K Department of Systems Biology, Harvard Medical School, Boston, MA, USA Marine Biological Laboratory, Woods Hole, MA, USA - - 2014
The large cells in early vertebrate development face an extreme physical challenge in organizing their cytoplasm. For example, amphibian embryos have to divide cytoplasm that spans hundreds of micrometres every 30 min according to a precise geometry, a remarkable accomplishment given the extreme difference between molecular and cellular scales in ...
Azimzadeh Juliette J CNRS/Université Paris-Diderot, Institut Jacques Monod, 15 rue Hélène Brion, 75209 Paris cedex 13, France - - 2014
The centrosome is the main organizer of the microtubule cytoskeleton in animals, higher fungi and several other eukaryotic lineages. Centrosomes are usually located at the centre of cell in tight association with the nuclear envelope and duplicate at each cell cycle. Despite a great structural diversity between the different types ...
Eyice O O School of Life Sciences, University of Warwick, Coventry, UK, CV4 7AL, - - 2014
Cell-specific ammonia oxidation rate (AOR) has been suggested to be an indicator of the performance of nitrification reactors and to be used as an operational parameter previously. However, published AOR values change by orders of magnitude and studies investigating full-scale nitrification reactors are limited. Therefore, this study aimed at quantifying ...
Zhong Haihong H Oncology Research, MedImmune - - 2014
MEDI-573 is a human antibody that neutralizes insulin-like growth factor (IGF)-1 and IGF-2. IGFs are over-expressed in multiple types of cancer; their over-expression is a potential mechanism for resistance to IGF-1 receptor (IGF-1R)-targeting therapy. Effects of IGF on cell proliferation, differentiation, and survival are mediated through its binding to and ...
Zheng Shuyao S Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida College of Medicine, University of Florida, 1275 Center Dr, Room J597, Gainesville, FL, 32610-0275, - - 2014
Clinical onset of type 1 diabetes (T1D) is thought to result from a combination of overt beta cell loss and beta cell dysfunction. However, our understanding of how beta cell metabolic abnormalities arise during the pathogenesis of disease remains incomplete. Despite extensive research on the autoimmune nature of T1D, questions ...
Oróstica María L ML Laboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, ChileLaboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, - - 2014
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor (ER) with subsequent production of cAMP and inositol triphosphate (IP3). However, the role of the different oviductal cellular phenotypes on this ...
Freund Guillaume G Ecole Supérieure de Biotechnologie de Strasbourg, UMR 7242, CNRS/Université de Strasbourg, Boulevard Sébastien Brant, Illkirch, - - 2014
Intrabodies, when expressed in cells after genetic fusion to fluorescent proteins, are powerful tools to study endogenous protein dynamics inside cells. However, it remains challenging to determine the conditions for specific imaging and precise labelling of the target antigen with such intracellularly expressed antibody fragments. Here, we show that single-chain ...
Tatematsu Tsutomu T Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, - - 2014
Advances in the molecular segmentation of lung cancer has raised the possibility that neurotrophic tyrosine kinase receptor (NTRK) 1 fusions and NTRK1-3 expression may be promising molecular targets for future therapeutic interventions. We investigated the antitumor effects of a selective pan-NTRK inhibitor, AZD7451, by evaluating its antiproliferative effects on the ...
Dai Bingling B School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Eupolyphaga sinensis Walker has been reported to have anticoagulation, antithrombotic, liver protective and antitumor effects. In the present study, the inhibitory effects on proliferation of A549 human non‑small cell lung cancer cells and the underlying mechanisms were examined. Firstly, three solvents, 70% ethanol, distilled water and 95% ethanol, were used ...
Lin Chuang-Yu CY Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou, Taoyuan, - - 2014
Chitosan is a choice material for scaffolds in regenerative medicine. One of the applications is to bridge the damaged peripheral nerves. Previous studies showed that combination of chitosan conduits and cultured Schwann cells could increase the opportunity for re-connection of broken nerves. It has also been known that Schwann cells ...
Ganji Yasaman Y Faculty of Biomedical Engineering, Amirkabir University of Technology, 424 Hafez Ave., Tehran, Iran. Electronic address: - - 2014
Gold nanotubes/nanowires (GNT/NW) were synthesized by using the template-assisted electrodeposition technique and mixed with castor oil-polyethylene glycol based polyurethane (PU) to fabricate porous composite scaffolds for biomedical application. 100 and 50ppm of GNT/NW were used to synthesize composites. The composite scaffolds were characterized by Fourier transform infrared spectroscopy, dynamic mechanical ...
Lawson Tracy T School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, - - 2014
1064 I. 1064 II. 1066 III. 1066 IV. 1068 V. 1069 VI. 1070 VII. 1070 VIII. 1070 IX. 1071 X. 1072 XI. 1074 XII. 1074 1076 References 1076 SUMMARY: Stomata control gaseous fluxes between the internal leaf air spaces and the external atmosphere. Guard cells determine stomatal aperture and must ...
Badowski Michael M Department of Immunobiology, College of Medicine, The University of Arizona, Tucson, Arizona, - - 2014
Cord tissue (CT) storage is promoted as an opportunity to preserve a source of mesenchymal stromal cells (MSCs) for future use. We analyzed maximal MSC yields from fresh and frozen CT including functional capacity after long-term cryopreservation as a means of assessing potential utility. CT was evaluated immediately upon harvest ...
England Ryan W RW From the Departments of *Surgery, †Obstetrics and Gynecology, and ‡Pathology, College of Physicians and Surgeons, Columbia University, New York, - - 2014
Infantile hemangiomas (IHs) are the most common tumor of infancy, yet there are no Food and Drug Administration-approved therapeutics to date. Recently, the nonselective β-adrenergic-blocker propranolol has been shown to be a safe and effective means of treating IHs, although its mechanism has yet to be elucidated. We have previously ...
Huang Xiang X Department of Urology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, P.R. - - 2014
Hypoxia-inducible factor (HIF)-1α has been reported to be associated with malignancy in a number of types of cancer. However, the role of HIF-1 α in the regulation of prostate cancer (PCa) growth has yet to be elucidated. The present study aimed to investigate the effect of HIF-1α on the biological ...
Shi Shuqing S Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. - - 2014
The present study aimed to investigate the effect of shikonin on autophagy in BXPC-3 human pancreatic cancer cells and its underlying mechanism. Cell viability was assessed using the Cell Counting Kit-8 assay and the expression of light chain (LC) 3, p62, phosphoinositide 3-kinase (PI3K), Akt, phosphorylated (p)-PI3K and p-Akt was ...
Xu Kaiwu K Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. - - 2014
Single nucleotide polymorphisms (SNPs) are associated with the development of certain types of cancer. The present study aimed to investigate the association between X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2) SNPs and colorectal cancer (CRC) cell sensitivity to the poly(ADP-ribose) polymerase (PARP) 1 inhibitor olaparib (AZD2281). ...
Yuan Ping P Department of Thoracic Surgery, First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. - - 2014
Telomerase Cajal body protein 1 (TCAB1) is a telomerase holoenzyme, which is markedly enriched in Cajal bodies (CBs) and facilitates the recruitment of telomerase to CBs in the S phase of the cell cycle. This recruitment is dependent on TCAB1 binding to a telomerase RNA component. The majority of cancer ...
Mu Qitian Q Department of Hematology, Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310003, P.R. China ; Key Laboratory of Hematopoietic Malignancies of Zhejiang Province, Hangzhou, Zhejiang 310003, P.R. China ; Laboratory of Stem Cell Transplantation, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. - - 2014
Adult T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis. Although it has been found that activation of Notch1 signaling occurs in >50% T-ALL patients, γ-secretase inhibitors that target Notch1 signaling are of limited efficacy. However, c-Myc is an important direct target of Notch1 and, thus, c-Myc is another potential ...
Zhang Xianqing X Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
The aim of the present study was to investigate the anti‑tumor effect of apogossypolone (ApoG2) on human LNCaP cells in vitro and in vivo. Cell viability was evaluated using an MTT assay. Cell autophagy and apoptosis were detected by flow cytometry and using a terminal deoxynucleotidyl transferase dUTP nick end labeling assay, ...
Wu Jianyue J Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. - - 2014
The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combination with X-ray irradiation (10 Gy, 20 min), ...
Gao Qi Q Department of Biochemistry, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. - - 2014
Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor which regulates various cellular functions. The aim of the present study was to analyze the function of PTEN gene expression in squamous cell carcinoma (SCC) cells. This gene exhibits a unique function in cell migration and proliferation during the early ...
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