Search Results
Results 401 - 450 of 30244
< 4 5 6 7 8 9 10 11 12 13 14 >
Ma Li L Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300050, P.R. - - 2014
AG1478 is a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. The effect of AG1478 on the A549/DDP (cisplatin-resistant human lung adenocarcinoma) cell line is unknown. The aim of the present study was to investigate the effects of AG1478 on the A549/DDP cell line and its sensitive parental A549 ...
Yang Yang Y Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. - - 2014
Saw palmetto extract can induce the apoptosis of prostate cancer cells. The aim of the present study was to investigate the effect of saw palmetto extract on the phosphatidylinositol 3-kinase (PI3K)/Akt signaling transduction pathway in human glioma U87 and U251 cell lines. Suspensions of U87 and U251 cells in a ...
Jin Gang G Department of Medical Imaging, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China ; The No. 211 Hospital of the People's Liberation Army, Harbin, Heilongjiang 150086, P.R. - - 2014
Protein O-glucosyltransferase 1 (POGLUT1) is a novel gene that was initially isolated and identified from the bone marrow cells of patients with myelodysplastic syndrome/acute myeloid leukemia. Previous findings have suggested that POGLUT1 promotes the proliferation of U937 human tissue lymphoma cells. Furthermore, POGLUT1 has been identified in other tissues, including ...
Li Yun Y Department of Respiratory Medicine, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, P.R. China ; Department of Respiratory Medicine, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, P.R. - - 2014
The aim of the present study was to investigate the potential role of microRNA (miRNA or miR) in invasion and metastasis of non-small cell lung cancer (NSCLC). miRNA-microarray analysis was used to detect the differentially expressed miRNAs between various metastatic levels of NSCLC cells. The microarray results were verified by ...
Zhang Dejun D Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. - - 2014
The aim of the present study was to investigate whether radiation induces the mammalian target of rapamycin (Rap) (mTOR) signaling pathway in esophageal carcinoma Eca109 cells, and whether mTOR inhibition by rapamycin increases Eca109 cell radiosensitivity. Changes in the levels of mTOR signaling pathway and DNA damage-repair proteins in Eca109 ...
Zhang Qiu-Yue QY Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China ; Pediatrics Intensive Care Units, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
The aim of the present study was to investigate water transport dysfunction in alveolar epithelial type II cells (AECII), which were exposed to hyperoxia, and to investigate the mechanism of pulmonary edema resulting from hyperoxic lung injury. The lung cells of newborn rats were isolated for primary cell culture and ...
Wang Wei W Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. - - 2014
This study aimed to investigate the lethal effect of the combination of bluetongue virus (BTV) and radiation on RM-1 murine prostate cancer cells in vitro and in vivo. Various cell lines were infected with BTV and the cytotoxicity was tested by a lactate dehydrogenase (LDH) release bioassay. Additionally, the RM-1 ...
Chen Zhangxing Z Department of Gastroenterology, The 174th Hospital of the PLA, Xiamen University, Xiamen, Fujian 361003, - - 2014
The role of LIM domain-containing protein 1 (LIMD1) in the multidrug resistance of colorectal carcinoma (CRC) has not yet been established. The aim of the current study was to investigate the chemosensitivity of CRC multidrug-resistant (MDR) cells following the silencing of LIMD1. The MDR phenotypic Colo205 and HCT-8 cell lines ...
Peng Zhengjun Z Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Guangdong Province Key Laboratory of Stomatology Guangzhou, Sun Yat-Sen University, Guangdong, - - 2014
During tooth development, the special structure of dental follicle and dental papilla enables dental papilla cells (DPCs) and dental follicle cells (DFCs) to make contact with each other. Octamer-binding transcription factor 4 (Oct-4), sex determining region Y box-2 (SOX-2), and cellular homologue of avian myelocytomatosis virus oncogene (MYC) (OSM) are associated ...
Svajdler Marián M *Department of Pathology, Louis Pasteur University Hospital, Košice, Slovakia; †Clinic of Plastic, Reconstructive and Aesthetic Surgery, Louis Pasteur University Hospital, Košice, Slovakia; ‡Pavol Jozef Šafárik University, Košice, Slovakia; and §Šikl's Department of Pathology, Charles University in Prague, Faculty of Medicine in Pilsen, and Bioptical Laboratory, Pilsen, Czech - - 2014
: The authors report a case of cutaneous angiosarcoma, composed predominantly of cytologically bland foamy cells, mimicking cutaneous xanthoma, dermal clear cell mesenchymal neoplasm, or clear cell dermatofibroma. The tumor occurred on the forehead and scalp of an 86-year-old white man with no history of radiation exposure. The tumor cells ...
Osipovich Anna B AB Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2014
Insulinoma associated 1 (Insm1) plays an important role in regulating the development of cells in the central and peripheral nervous systems, olfactory epithelium and endocrine pancreas. To better define the role of Insm1 in pancreatic endocrine cell development we generated mice with an Insm1(GFPCre) reporter allele and used them to ...
Firulli Beth A BA Riley Heart Research Center, Herman B Wells Center for Pediatric Research, Division of Pediatric Cardiology, Departments of Anatomy and Medical, Biochemistry, and Molecular Genetics, Indiana Medical School, 1044 W. Walnut Street, Indianapolis, IN 46202-5225, - - 2014
In this study we examine the consequences of altering Hand1 phosphoregulation in the developing neural crest cells (NCCs) of mice. Whereas Hand1 deletion in NCCs reveals a nonessential role for Hand1 in craniofacial development and embryonic survival, altering Hand1 phosphoregulation, and consequently Hand1 dimerization affinities, in NCCs results in severe ...
Colopy Sara A SA Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, - - 2014
Homeostatic maintenance and repair of the bladder urothelium has been attributed to proliferation of keratin 5-expressing basal cells (K5-BC) with subsequent differentiation into superficial cells. Recent evidence, however, suggests that the intermediate cell layer harbors a population of progenitor cells. We use label-retaining cell (LRC) methodology in conjunction with a ...
Xu Xia X National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, People's Republic of China; Institute of Biomedical Engineering, Department of Engineering Science, Oxford University, - - 2014
There is a need to preserve cell-seeded scaffolds or cell-matrix constructs for tissue-engineering and other applications. Cryopreservation is likely to be the most practical method. The aim of this study was to investigate how cryopreservation affects cells attached to different substrates and how they respond differently from those in suspension. ...
Dastagir Khaled K 1 Department of Plastic, Hand, and Reconstructive Surgery, Hannover Medical , 30659 Hannover, Germany - - 2014
Abstract Various diseases, injuries, and congenital abnormalities may result in degeneration and loss of organs and tissues. Recently, tissue engineering has offered new treatment options for these common, severe, and costly problems in human health care. Its application is often based on the usage of differentiated stem cells. However, despite ...
Yang X-N XN Orthopedic Department, Xuzhou No. 1 Hospital, Xuzhou, China. - - 2014
To investigate the effect of targeted antiosteosarcoma methotrexate-bisphosphonate conjugate on growth inhibition and apoptosis in human osteosarcoma MG-63 cells. MG-63 cells were treated with various concentrations of methotrexate-bisphosphonate conjugate and apoptosis was monitored via an MTT assay, cell morphology, TUNEL assay and flow cytometry analysis. The survival rate of MG-63 ...
Gakhar Gunjan G Department of Medicine, Weill Cornell Medical College, New York City, NY, - - 2014
Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. Cationic polymers effects on PC3 prostate cancer cells and normal prostate ...
Ortega-Calderón Yasmín Nansi YN Laboratory of Cell Biology, Department of Physiology, National Institute of Cardiology, Ignacio Chávez, - - 2014
Dehydroepiandrosterone (DHEA), an adrenal steroid which is most abundant in human plasma, has a protective role against several types of cancer; however, its mechanisms of action are unknown. We evaluated the effect of DHEA on the proliferation and migration of three cell lines derived from cervical cancer. Cell proliferation was ...
Saibu Morounke M Department of Biotechnology, University of the Western Cape, Bellville, South - - 2014
Quinone-containing compounds can induce cell death in cancer cells and are, therefore, promising lead compounds for the development of novel anti-cancer drugs. In the present study, we evaluated the cytotoxic effects of fifteen novel synthetic quinone-containing compounds in cell cultures in an attempt to establish structure/activity relationships for these compounds. ...
VON Schulz-Hausmann Sarah Annette SA University Hospital Bonn, Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Bonn, - - 2014
Advanced renal cancer still has a very poor prognosis. In this regard recent investigations demonstrated a constitutive activation of the Wnt signaling pathway in renal cell carcinoma (RCC) thereby promoting an exaggerated cell proliferation. Especially, β-catenin overactivation and the functional loss of endogenous Wnt antagonists are associated with RCC carcinogenesis ...
Umebayashi Masayo M Fukuoka General Cancer Clinic, Fukuoka, - - 2014
Cancer stem-like properties of various types of cancer, including pancreatic cancer, one of the most aggressive types, correlate with metastasis, invasion, and therapeutic resistance. More importantly, chemoresistance in cancer stem-like cells (CSLCs) is a critical problem for eradication of pancreatic cancer. Several cell surface markers, such as CD44 and epithelial ...
Wang Tongpeng T Department of Mathematics, Institute of Systems Biology, Shanghai University, Shanghai 200444, People's Republic of China. - - 2014
Simple mutual-inhibition networks are frequently occurring motifs in transcriptional regulatory networks for cell lineage commitment. Stable attractors represent cell commitment states. However, how progenitor-specific transcription factors stabilise progenitor cells and commit them to different cell fates remains unexplained. In this study, the authors represent the cell commitment motifs composed of ...
Galluzzi Lorenzo L 1] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France [3] Gustave Roussy Comprehensive Cancer Center, Villejuif, - - 2014
In a majority of pathophysiological settings, cell death is not accidental - it is controlled by a complex molecular apparatus. Such a system operates like a computer: it receives several inputs that inform on the current state of the cell and the extracellular microenvironment, integrates them and generates an output. ...
Capel Blanche B Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, - - 2014
Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin ...
Zhou Huanping H Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA. California NanoSystems Institute, University of California, Los Angeles, CA 90095, - - 2014
Advancing perovskite solar cell technologies toward their theoretical power conversion efficiency (PCE) requires delicate control over the carrier dynamics throughout the entire device. By controlling the formation of the perovskite layer and careful choices of other materials, we suppressed carrier recombination in the absorber, facilitated carrier injection into the carrier ...
Vázquez Patricia P 3D (Development, Differentiation, Degeneration) Lab, Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, - - 2014
Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cell development. We studied the immunohistochemical ...
Zhao Zhenshan Z Department of Medicine and Division of Endocrinology, Gerontology & Meatbolism, Stanford University School of Medicine, Stanford, CA - - 2014
Loss of β-cell mass is a cardinal feature of diabetes. Consequently, developing medications to promote β-cell regeneration is a priority. 3'-5'-Cyclic adenosine monophosphate (cAMP) is an intracellular second messenger that modulates β-cell replication. We investigated whether medications that increase cAMP stability or synthesis selectively stimulate β-cell growth. To identify cAMP ...
Smith T B TB Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, - - 2014
We have shown previously that a network of mononuclear phagocytes (MPs) expressing macrophage and dendritic cell markers such as CD11c, F4/80 and CX3CR1, lines the base of the epididymal tubule. However, in the initial segment (IS) and only in that particular segment, epididymal MPs establish extremely close interactions with the ...
Yu Dayeon D Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Ku, Seoul, 120-752, - - 2014
CD44 is a cell surface protein and it is widely used as a cancer stem cell marker in various cancer types including gastric cancer. We conducted proteomic analysis in CD44(+) and CD44(-) gastric cancer cells to understand characteristics of CD44(+) and CD44(-) cells. In the present study, we sorted cells ...
Orenstein Jan Marc JM Department of Pathology, George Washington University Medical Center , Washington, DC , - - 2014
Abstract The so-called "enigmatic" unique "myofibroblast" has been erroneously substituted for virtually all things fibroblastic in soft tissue pathology and believed to be the ultimate fibrogenic cell. It is also internationally considered to be the mesenchymal cell in un-proven post-natal EMT, EMT organ/tissue fibrosis, and the assumption that EMT/MET is ...
Ari F F Faculty of Science and Arts, Department of Biology, Uludag University, 16059, Bursa, - - 2014
Successful cancer treatments still require more compounds to be isolated from natural sources. Thus, we have investigated anti-proliferative/apoptotic effects of methanolic extracts of lichen species Parmelia sulcata Taylor and Usnea filipendula Stirt on human lung cancer (A549, PC3), liver cancer (Hep3B) and rat glioma (C6) cells. Anti-proliferative effects were monitored ...
Pessina P P Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Montevideo, - - 2014
Immunoreactive proteins in follicular cells, fibroblasts and endothelial cells were assessed in canine thyroid carcinomas and healthy thyroid glands. No differences were detected in thyrotropin receptor and thyroglobulin staining between cancer and normal tissues, but expression was higher in follicular cells than in fibroblasts. Fibroblast growth factor-2 staining was more ...
Scheffel Dls - - 2014
SUMMARY Objectives : To evaluate the transdentinal cytotoxicity of three different concentrations of carbodiimide (EDC) or 5% glutaraldehyde (GA) on MDPC-23 cells. Methods : Seventy 0.4-mm-thick dentin disks obtained from human molars were adapted to artificial pulp chambers. MDPC-23 cells were seeded on the pulpal surface of the disks. After ...
Nagao-Kitamoto Hiroko H Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, - - 2014
Aberrant activation of the Hedgehog (Hh) pathway has been reported in several malignancies. We previously demonstrated that knockdown of GLI2 inhibited proliferation of osteosarcoma cells through regulation of the cell cycle. In this study, we analyzed the function of GLI2 in the pathogenesis of osteosarcoma metastasis. Immunohistochemical studies showed that ...
Lerche Mathilde H - - 2014
Cellular components are routinely catalogued by omics-approaches. Methods for interrogating the dynamic function of these components with chemical detail in intact living samples are far less routine. During the last few years, spectroscopy has improved to a level that enables detailed insights into the inner workings of living cells. Due ...
Sha Lin L Department of Radiology, Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Street, Dalian, 116027, - - 2014
The function of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established. However, the regulatory mechanisms modulating this phenomenon remain unclear. Homeobox B9 (HOXB9) has been proposed as an oncogene in many cancer developments, but its function and underlying mechanisms in HCC metastasis remain unknown. HOXB9 modulates ...
Kimura Ayuko A Advanced Medical Research Center and Graduate School of Medical Life Science, Yokohama City University , Fukuura 3-9, Kanazawa, Yokohama 236-0004, - - 2014
Protein phosphorylation is one of the major factors involved in tumor progression and malignancy. We performed exploratory studies aimed at identifying phosphoproteins characteristic to cell lines derived from ovarian clear cell adenocarcinoma (CCA), a highly malignant type of ovarian cancer. Comparative phosphoproteome analysis revealed that the phosphopeptides of five SWI/SNF ...
Zhao X X State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, Xi'an, Shaanxi, - - 2014
Dysregulation of transcription factors (TFs) is associated with tumor progression, but little is known about TF expression patterns in the context of gastric cancer (GC) metastasis. Using array-based profile analysis, we found that 22 TFs showed differential activities between GC cell lines with low- and high-metastatic potential. Of this group ...
Kasper Stephen H SH SUNY College of Nanoscale Science & Engineering, Albany, NY, - - 2014
To design and synthesize a library of structurally-related, small molecules related to homologs of compounds produced by the plant Petiveria alliacea and determine their ability to interfere with AI-2 cell-cell communication and biofilm formation by oral bacteria. Many human diseases are associated with persistent bacterial biofilms. Oral biofilms (dental plaque) ...
Angelini Paola P Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, - - 2014
Nodular ganglioneuroblastoma is characterized by a macroscopic nodule of neuroblastoma within a ganglioneuromatous component. These two components have been considered to originate from separate clones, with the neuroblastoma clone accounting for the clinical behavior of nodular ganglioneuroblastoma. In order to investigate the clonal origin of the cellular components (neuroblasts, ganglion ...
Ahadian Samad S WPI-Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. - - 2014
In this manuscript, we demonstrate the rapid formation of three-dimensional (3D) embryonic stem cell (ESC) aggregates with controllable sizes and shapes in hydrogels using dielectrophoresis (DEP). The ESCs encapsulated within a methacrylated gelatin (GelMA) prepolymer were introduced into a DEP device and, upon applying an electric field and crosslinking of ...
Blais Anne A UMR 914 INRA- AgroParisTech Nutrition Physiology and Ingestive Behaviour, 16 rue Claude Bernard, 75005, Paris, France, - - 2014
This study was designed to analyse the effects of human (h) and bovine lactoferrin (bLF) on the growth and differentiation of intestinal cells using the mice model supplemented with Lactoferrin (LF) and the enterocyte-like model of Caco-2 cells which spontaneously differentiate after confluency. In mice, bLF supplementation increased jejunal villus ...
Saeed Duaa D Department of Histopathology, Charing Cross Hospital, Imperial College Healthcare NHS Trust and Imperial College, London, - - 2014
Toker cells are clear cells present in the squamous epithelium of the nipple of some women. In contrast to squamous epithelium, they are cytokeratin 7 (CK7) positive. The origin of these cells is not completely understood. It has been suggested that they may represent abortive glands or migratory ductal cells; ...
Qi Wenxiu - - 2014
BackgroundAcute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, thus enhancing the antitumor activity of DNA damaging agents. In this study, we investigated MK-1775 in AML cell ...
Autsavapromporn Narongchai - - 2014
Abstract Purpose: Radiation induced bystander effects have important implication in radiotherapy. Their persistence in normal cells may contribute to risk of health hazards, including cancer. This study investigates the role of radiation quality and gap junction intercellular communication (GJIC) in the propagation of harmful effects in progeny of bystander cells. ...
Trousse Françoise F Université Montpellier 2, Montpellier F-34095, France INSERM U710, University Montpellier 2, Montpellier F-34095, France EPHE, Paris F-75007, - - 2014
Cajal-Retzius (CR) cells are essential for cortical development and lamination. These pioneer neurons arise from distinct progenitor sources, including the cortical hem and the ventral pallium at pallium-subpallium boundary (PSB). CXCR4, the canonical receptor for the chemokine CXCL12, controls the superficial location of hem-derived CR cells. However, recent studies showed ...
Guo Jinhong J Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, 138682, Singapore; School of Microelectronics and Solid-State Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, P. R. China; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637459, - - 2014
Label-free detection technique has emerged as a powerful platform for biomedical applications since it can avoid laborious multi-step sample preparation. In this paper, we demonstrate a dual analysis of biological cells using a single microfluidic system combining optofluidic microscopy and resistive pulse sensing. Both red blood cells (RBCs) and circulating ...
Fadel Tarek R TR Department of Chemical Engineering, Yale University, PO Box 208284, New Haven, Connecticut 06511, - - 2014
Clinical translation of cell therapies requires strategies that can manufacture cells efficiently and economically. One promising way to reproducibly expand T cells for cancer therapy is by attaching the stimuli for T cells onto artificial substrates with high surface area. Here, we show that a carbon nanotube-polymer composite can act ...
Bertelsen Lotte B LB The MR Research Centre, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. Electronic address: - - 2014
Endothelial progenitor cells (EPCs) represent a heterogeneous cell population that is believed to be involved in vasculogenesis after ischemic diseases. EPCs could have a potential for future therapies with the purpose of enhancing endothelial repair. However, due to the low amount of these cells in circulation they have to be ...
Kang Dong-Wan DW Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital and School of Medicine, Busan, 602-739, Republic of - - 2014
Artificial nerve guidance conduits (aNGCs) prepared from polymer scaffolds and carbon nanotubes (CNTs) possess unique chemical and physical properties, and have been widely used in preclinical trials to promote neuronal differentiation and growth. However, there have been only a few reports on the clinical applicability of CNT sheets for proliferation ...
< 4 5 6 7 8 9 10 11 12 13 14 >