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Results 401 - 450 of 30333
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Saavedra-Ávila Noemí Alejandra NA http://orcid.org/0000-0003-3064-7254 Immunology Unit, Department of Experimental Medicine, Faculty of Medicine, University of Lleida, 25008 Lleida, Spain;Institut de Recerca Biomèdica de Lleida, 25198 Lleida, - - 2014
Type 1 diabetes is an autoimmune condition caused by the lymphocyte-mediated destruction of the insulin-producing β cells in pancreatic islets. We aimed to identify final molecular entities targeted by the autoimmune assault on pancreatic β cells that are causally related to β cell viability. Here, we show that cyclin D3 ...
Yang Zhang Z University of Copenhagen, - - 2014
The Chinese hamster ovary cell (CHO) is the major host cell factory for recombinant production of biological therapeutics primarily due to its "human-like" glycosylation features. CHO is used for production of several O-glycoprotein therapeutics including erythropoietin, coagulation factors, and chimeric receptor IgG1-Fc-fusion proteins, however, some O-glycoproteins are not produced efficiently ...
Nowotarski Stephanie H SH Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, - - 2014
Cells have evolved an elegant tuning mechanism to maintain tissue integrity, in which increasing mechanical tension stimulates actin assembly at cell-cell junctions. The mechanosensitive junctional protein α-catenin acts through vinculin and Ena/VASP proteins to reinforce the cell against mechanical stress.
Xu Huiming H Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, - - 2014
Tremendous efforts have been made to elucidate the molecular mechanisms that control the specification of definitive endoderm cell fate in gene-knockout mouse models and ESCs differentiation models, however the impact of unfolded protein response (UPR) due to the stress of the endoplasmic reticulum (ER) on the endodermal specification is not ...
Wang Wen-Horng WH Department of Medicinal Chemistry and Molecular - - 2014
The Syk protein-tyrosine kinase, a well characterized regulator of immune cell function, plays an increasingly recognized role in tumorigenesis as a promoter of cell survival in both hematological and nonhematological malignancies. We show here that the expression of Syk in MCF7 or MDA-MB-231 breast cancer cells or in DG75 B ...
Cronin Therese T Center for Advanced Retinal and Ophthalmic Therapeutics, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland jebennet@mail.med.upenn.edu - - 2014
In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. In particular, a therapeutic strategy under investigation for advanced ...
Wu Chia-Yen CY Department of Physiology, Tzu Chi University, No. 701, Sec. 3, Chung Yang Rd., Hualien, 97004, - - 2014
Hair cells are highly sensitive to environmental insults and other therapeutic drugs. The adverse effects of drugs such as aminoglycosides can cause hair cell death and lead to hearing loss and imbalance. The objective of the present study was to evaluate the protective activity of L-ascorbic acid, N-acetylcysteine (NAC) and ...
Park Jun Soo JS Chronic Disease Research Center, Keimyung University School of Medicine, Daegu 704-701, Republic of - - 2014
The inhibition of topoisomerase can suppress the growth of cancer cells and induce apoptosis. The aim of this study was to evaluate the anticancer effects and mechanisms of action of a novel topoisomerase inhibitor, 4-(furan-2-yl)-2-(pyridin-2-yl)-5,6-dihydro-1,10-phenanthroline (FPDHP). FPDHP suppressed the growth of Caki, A549, HT29 and MDA-MB-231 cells, and induced caspase-dependent ...
Dozawa Miki M Department of Life Science and Medical Bio-Science, School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, - - 2014
Background: Valproic acid (VPA) has been used to treat epilepsy and bipolar disorder. Several reports have demonstrated that VPA functions as a histone deacetylase (HDAC) inhibitor. While VPA is known to cause teratogenic changes in the embryonic zebrafish brain, its effects on neural stem cells (NSCs) in both the embryonic ...
Marques Juliana Mangolin JM Laboratory of Tissue and Cell Biology, Development and Research Institute, Universidade do Vale do Paraíba (UNIVAP), Urbanova, 12244-000 São José dos Campos, Brazil Laboratory of Dynamics of Cellular Compartments, Development and Research Institute, Universidade do Vale do Paraíba (UNIVAP), Urbanova, 12244-000 São José dos Campos, - - 2014
Low-level laser therapy has become an important tool for bio-modulation process. It can induce stimulatory or inhibitory effects according to cell behavior at specific irradiation. Our objective was to determine L929 cell line response to irradiation at λ 685 and 830 nm, concentrations of 5 and 10% fetal bovine serum and ...
Liu Kuai K Department of Hepatopancreatobiliary Surgery, The First Hospital, Jilin University, Changchun, Jilin Province, P.R. - - 2014
The miR‑222 cluster has been demonstrated to function as oncomiR in human hepatocellular carcinoma (HCC). miR‑222 confers chemotherapy drug resistance in various cancers, including HCC. However, the effects and mechanisms by which miR‑222 regulates liver tumorigenicity and confers sorafenib (SOR) resistance remain unclear. Here we first investigated the miR‑222 effect ...
Neves Erasmovlane S B ES Campus Senador Helvídio Nunes de Barros (CSHNB), Laboratório de Citogenética Vegetal e Animal, Núcleo de Pesquisa Aplicada à Saúde e ao Meio-Ambiente (NUPBSAM), Universidade Federal do Piauí (UFPI), Picos, PI, - - 2014
This study aimed to evaluate the effects of aqueous extracts of dried Phyllanthus niruri L. (stonebreaker) leaves on Allium cepa L. root meristem cells at four concentrations, 0.02 (usual concentration), 0.04, 0.06 and 0.08mg/mL and exposure times of 24 and 48 hours. For each concentration we used a group of ...
Zwollo Patty P Department of Biology, The College of William and Mary, Williamsburg, VA, 23185. Electronic address: - - 2014
Bacterial Cold Water Disease (BCWD) is a chronic disease of rainbow trout, and is caused by the gram-negative bacterium Flavobacterium psychrophilum (Fp), a common aquaculture pathogen. The National Center for Cool and Cold Water Aquaculture has bred two genetic lines of rainbow trout: a line of Fp-resistant trout (ARS-Fp-R or ...
Jia Zhuqing Z Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing 100191, P.R. - - 2014
Autophagy plays important roles in adipogenesis and neuron development. However, how autophagy contributes to cardiac development is not well understood. The main aim of our study was to determine the association between autophagy and myocardial differentiation and its roles in this process. Using a well-established an in vitro cardiomyocyte differentiation ...
Jowsey Paul A PA Medical Toxicology Centre, Wolfson Unit, Newscastle University, Newcastle upon Tyne, NE 4AA, United Kingdom. Electronic address: - - 2014
Sulphur mustard (SM) is a highly toxic chemical agent and poses a current threat to both civilians and military personnel in the event of a deliberate malicious release. Acute SM toxicity develops over the course of several hours and mainly affects the skin and mucosal surfaces of the eyes and ...
Crawshaw Adam D AD Institute for Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, 3rd Floor Cookson Building, Newcastle upon Tyne, NE2 4HH, - - 2014
Formation of endospores allows some bacteria to survive extreme nutrient limitation. The resulting dormant cell, the spore, persists in the environment and is highly resistant to physical and chemical stresses. During spore formation, cells divide asymmetrically and the mother cell engulfs the developing spore, encasing it within a double membrane ...
Ma Shouzhi S State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. - - 2014
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignant cancers worldwide, with a poor 5-year prognosis. Karyopherin α 2 (KPNA2) is a nuclear membrane protein that mediates nucleus-to-cytoplasm shuttling. Its expression is elevated in multiple forms of cancer, and it can be secreted into the serum. However, the concentration ...
Francisco-Morcillo Javier J Departamento de Biología Celular, Facultad de Ciencias, Universidad de Extremadura, Avda. de Elvas s/n, Badajoz, 06006, - - 2014
Programmed cell death (PCD), together with cell proliferation, cell migration, and cell differentiation, is an essential process during development of the vertebrate nervous system. The visual system has been an excellent model on which to investigate the mechanisms involved in ontogenetic cell death. Several phases of PCD have been reported ...
Lamoureux Francois F Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes F-44035, France; INSERM, UMR 957, Nantes F-44035, France; LUNAM Université; Equipe labellisée LIGUE 2012, Nantes, - - 2014
Purpose: Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants new strategies still needed to improve overall patient survival. Among new therapeutic approaches, zoledronic acid (ZOL) represents a promising adjuvant molecule to chemotherapy to limit the osteolytic component of bone tumors. However, ...
D'Agostino Massimo M Department of Molecular medicine and Medical Biotechnology, University of Naples Federico II, Naples, - - 2014
The newly synthesized mutant L501fsX533 Frizzled-4 form and the alpha3beta4 nicotinic acetylcholine receptor expressed in the absence of nicotine accumulate in the endoplasmic reticulum of COS-7 cells and induce the formation of large areas of smooth and highly convoluted cisternae. This results in a generalized block of the transport to ...
Li Rong R Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, West Huaihai Road 241, Shanghai, China, - - 2014
Vitamin D has the capability to inhibit tumor cell proliferation and promote tumor cell apoptosis but whether this mechanism exists in lung adenocarcinoma cells remains to be studied. Our objective is to explore whether vitamin D has the capability to inhibit lung adenocarcinoma cell proliferation and synergize with cisplatin. Our ...
Jing Yu Y International Joint Cancer Institute, The Second Military Medical University, Shanghai, 200433, - - 2014
In laboratory scale therapeutical protein production, cell clumps form typically in shake flasks, which hinders cell growth and decreases protein yield. To minimize clumps during the culture of Chinese hamster ovary cells, we employed the combination of two reagents, dextran sulfate (DS) and recombinant trypsin (r-trypsin). Our results showed that ...
Panikov Nicolai S NS Department of Biology, Northeastern University, Boston, MA 02115; Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA - - 2014
Intensive microbial growth typically observed in laboratory rarely occurs in nature. Because of severe nutrient deficiency, natural populations exhibit near-zero growth (NZG). There is a long-standing controversy about sustained NZG; specifically, whether there is a minimum growth rate below which cells die or whether cells enter a non-growing maintenance state. ...
Pollen Alex A AA 1] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA. - - 2014
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell populations and lineage relationships but require efficient methods for cell capture and mRNA sequencing. Although cellular barcoding strategies allow parallel sequencing of single cells at ultra-low depths, the limitations of shallow sequencing have not been investigated directly. ...
Bagheri Fatemeh F Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, - - 2014
Alterations in expression of the DFF40 gene have been reported in some cancers. This study is an in vitro study of the therapeutic effects of gene transfer that lead to elevation in DFF40 expression within T-47D cells in the presence of sulfonamide drugs. In this study, we have constructed a ...
Li Jin J Regeneration Lab and Experimental Center of Life Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, - - 2014
Factors responsible for the rapid proliferative properties of embryonic stem (ES) cells are largely unknown. MicroRNA-221/222 (miR-221/222) regulate proliferation in many somatic cells, however, their roles in proliferation of ES cells are unclear. In this study, E14 mouse ES cells proliferation was determined by total cell counting, Cell Counting Kit ...
Jiang Lin L Institute of Biliary Tract Disease, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, - - 2014
Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chan Su, has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, no detailed studies have so far been reported on its action on human gallbladder carcinoma cells. In this study, ...
Rais Yoach Y Institute of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, P.O. Box 12, 76100, Rehovot, - - 2014
Mechanical load plays a significant role in bone and growth-plate development. Chondrocytes sense and respond to mechanical stimulation; however, the mechanisms by which those signals exert their effects are not fully understood. The primary cilium has been identified as a mechano-sensor in several cell types, including renal epithelial cells and ...
Rampon Christine C Centre Interdisciplinaire de Recherche en biologie (CIRB), CNRS UMR 7241//INSERM U1050, Collège de France, 11, Place Marcelin Berthelot, 75231, Paris Cedex 05, - - 2014
A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In this context, we explore its possible mode of action in ...
Fei Fei F State Key Laboratory of Cancer Biology, Cell Engineering Research Center & Department of Cell Biology, The Fourth Military Medical University, Xi'an, - - 2014
It has been reported that CD147 and CD98 heavy chain (CD98hc) form a complex on the cell plasma membrane of several cancers; however, whether this complex exists in non-small cell lung cancer (NSCLC) cells and affects the prognosis of patients remains to be elucidated. The expression of CD147 and CD98hc ...
Brisdelli Fabrizia F Department of Biotechnological and Applied Clinical Science, University of L'Aquila, Via Vetoio, Coppito 2, 67100, L'Aquila, Italy, - - 2014
This study investigated the effects of sinusoidal ELF-MF (1 mT; 50 Hz) on the apoptosis induced by four different compounds, namely vinblastine, etoposide, quercetin, and resveratrol, in human K562 chronic myeloid leukemia cells. The exposure to ELF-MF did not affect growth and viability of untreated K562 cells and did not influence the ...
Kim Wootae W Department of Pharmacology, School of Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-701, Republic of - - 2014
Melatonin exhibits oncostatic activity in several cancers but does not lead to cytotoxicity in estrogen receptor (ER)-negative non-small cell lung cancers (NSCLCs). In an effort to overcome the melatonin resistance of these cancers, we investigated whether cell cycle and apoptosis regulator 2 (CCAR2) depletion would promote apoptosis following genotoxic stress ...
Wesley Umadevi V UV Department of Neurological Surgery, University of Wisconsin, Box 8660 Clinical Science Center, 600 Highland Ave, Madison, WI, 53792, USA, - - 2014
Sphingomyelin synthase (SMS) is a key enzyme involved in the generation of sphingomyelin (SM) and regulation of cell growth and survival. However, the effects of SMS on neuronal cell proliferation and cell cycle progression are not completely elucidated. In this study, we examined the direct effects of SMS1 in regulating ...
Jiang LiBo L Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, - - 2014
Although glucosamine has been suggested to be effective in the treatment of osteoarthritis, its effect on disc degeneration remains unclear. We sought to explore whether glucosamine can activate autophagy in rat nucleus pulposus (NP) cells and protect cells treated with IL-1β or hydrogen peroxide (H2 O2 ). Autophagy in cells ...
Magableh Ali A Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, - - 2014
The pontine parabrachial nucleus (PBN) receives substantial descending input from higher order forebrain regions that exerts inhibitory and excitatory influences on taste-evoked responses. Somatostatin (Sst) and corticotrophin releasing hormone (Crh) reporter mice were used in conjunction with injection of the retrograde tracer CTb-488 into the caudal PBN to determine the ...
Bogado Rodrigo F E RF aFaculty of Exact, Chemical and Natural Sciences, University of Misiones, Argentina Departments of bGenetics cClinics dPediatrics, Ribeirão Preto School of Medicine eDepartment of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, - - 2014
Polo-like kinase 1 (PLK1), a key regulator of mitosis, is often overexpressed in childhood cancers and is associated with poor prognosis. Previous reports have shown that inhibition of PLK1 might serve as a promising anticancer treatment for osteosarcoma. In this study, we tested the second-generation PLK1 inhibitors BI 6727 and ...
Tian Li L aCancer Center, 307 Hospital of Academy of Military Medical Sciences bDepartment of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences cDepartment of Special Care Medical Center, Navy General Hospital dOrgan Transplantation Institute, 309 Hospital of Chinese People's Liberation Army, Beijing, - - 2014
Schlafen-11 (SLFN11) showed a highly significant positive correlation with the response of topoisomerase inhibitors in cancer cell lines derived from prostate, lung, etc. However, this finding has not been validated in colorectal cancers (CRCs). Although irinotecan (CPT-11), a topoisomerase inhibitor, is one of the most important drugs in the treatment ...
Hindle Paul P Department of Trauma and Orthopaedic Surgery, The Royal Infirmary of Edinburgh, Edinburgh, The United Kingdom; Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, Edinburgh, The United - - 2014
Cell viability is crucial for effective cell-based cartilage repair. The aim of this study was to determine the effect of handling the membrane during matrix-induced autologous chondrocyte implantation surgery on the viability of implanted chondrocytes. Images were acquired under five conditions: (i) Pre-operative; (ii) Handled during surgery; (iii) Cut edge; ...
Kozlova L V LV Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Science, Kazan, Lobachevskij str., 2/31, 420111, Russia - - 2014
Plant cell enlargement is unambiguously coupled to changes in cell wall architecture, and as such various studies have examined the modification of the proportions and structures of glucuronoarabinoxylan and mixed-linkage glucan in the course of cell elongation in grasses. However, there is still no clear understanding of the mutual arrangement ...
Xi Hao H Department of Pathology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. - - 2014
Peroxiredoxin 3 (Prx3) is a mitochondrial member of the antioxidant family of thioredoxin peroxidases that uses mitochondrial thioredoxin 2 as a source of reducing equivalents to scavenge hydrogen peroxide (H2O2). Here, we report that the protein levels of Prx3 are significantly reduced in VHL-deficient clear cell renal cell carcinoma (CCRCC). ...
Chiappini Florencia F Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos, Buenos Aires, - - 2014
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. In this study we have demonstrated that HCB induced loss of cell viability and alterations in cell cycle regulation in FRTL-5 rat thyroid cells. Analysis of cell cycle distribution by flow cytometric analysis demonstrated that HCB induced cell cycle ...
Lemmer Yolandy Y Material Science and Manufacturing, CSIR, Pretoria, South Africa - - 2014
A mathematical model is presented of the growth and death of bacilli in a granuloma. The granuloma is treated with isoniazid (INH), a drug that inhibits the synthesis of mycolic acids (MA). Since MA is an essential component of cell walls, the organisms fail to reach maturity if deficient in ...
Goo Hui-Gwan HG Division of Life Sciences, Korea University, Seoul 136-701, - - 2014
High temperature requirement A2 (HtrA2)/Omi is a serine protease localized in mitochondria. In response to apoptotic stimuli, HtrA2 is released to the cytoplasm and cleaves many proteins, including XIAP, Apollon/BRUCE, WT1, and Ped/Pea-15, to promote apoptosis. However, the function of HtrA2 in mitochondria under normal conditions remains unclear. Here, we ...
Tang Qiong Q Department of Nephrology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China 210011, PR - - 2014
Epithelial-to-mesenchymal transition (EMT) is a highly conserved physiological program involved in renal fibrosis. Previous studies have shown that transforming growth factor (TGF)-β1 induces EMT in human kidney proximal tubular epithelial cells (HK-2 cells), whereas salvianolic acid B (Sal B) has a protective effect against EMT. The molecular pathogenesis of such ...
Hartwig Kerstin K EVER Neuro Pharma GmbH, Unterach, - - 2014
Cerebrolysin (EVER Neuro Pharma GmbH, Austria) is a peptidergic drug indicated for clinical use in stroke, traumatic brain injury and dementia. The therapeutic effect of Cerebrolysin is thought to ensure from its neurotrophic activity, which shares some properties with naturally occurring neurotrophic factors. However, the exact mechanism of action of ...
Farmahin Reza R Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada; Environment Canada, National Wildlife Research Centre, Ottawa, Ontario K1A 0H3, - - 2014
Avian species differ in sensitivity to the toxic effects of dioxin-like compounds (DLCs) and recent reports have provided insight into the molecular mechanisms underlying this variability. The sensitivity of avian species to DLCs is associated with the identity of amino acids at positions 324 and 380 within the ligand-binding domain ...
Nueda María-Luisa ML School of Pharmacy, Biochemistry and Molecular Biology Branch, Department of Inorganic, Organic Chemistry and Biochemistry, Biomedical Research Unit CSIC/UCLM, Albacete, Spain. Electronic address: - - 2014
NOTCH receptors regulate cell proliferation and survival in several types of cancer cells. Depending on the cellular context, NOTCH1 can function as an oncogene or as a tumor suppressor gene. DLK1 is also involved in the regulation of cell growth and cancer, but nothing is known about the role of ...
William Wong G G Department of Physiology, Johns Hopkins University School of Medicine, Baltimore 21205, Maryland, USA. Electronic address: - - 2014
The sentinel roles of mammalian mast cells (MCs) in varied infections raised the question of their evolutionary origin. We discovered that the test cells in the sea squirt Ciona intestinalis morphologically and histochemically resembled cutaneous human MCs. Like the latter, C. intestinalis test cells stored histamine and varied heparin•serine protease ...
Weng Junquan J Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, - - 2014
The role of autophagy is still a controversy in cancer development. In our previous study, we confirmed that decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma (TSCC). However, the role of autophagy-related protein, Beclin1, has not well been documented in TSCC. In this study, we aim ...
Jadali Zohre Z Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis.A systematic review of ...
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