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Results 401 - 450 of 25415
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Tarpley Mike M 1801 Fayetteville St, BRITE Bldg, Rm 1019, North Carolina Central University, Durham, NC 27707, U.S.A. - - 2014
Triple-negative breast cancer (TNBC) is an aggressive sub-type of breast cancer. Dasatinib and bosutinib are FDA-approved Src/Abl kinase inhibitor drugs. Dasatinib potently inhibits the proliferation of many TNBC cell lines. The cell viability/proliferation for a panel of 4 TNBC cell lines was measured by detection of cellular ATP levels and ...
Perchellet Jean-Pierre H JP Anti-Cancer Drug Laboratory, Kansas State University, Division of Biology, Ackert Hall, Manhattan, KS 66506-4901, U.S.A. - - 2014
Synthetic 6,7-annulated-4-substituted indole compounds, which elicit interesting antitumor effects in murine L1210 leukemia cells, were tested for their ability to inhibit human HL-60 tumor cell proliferation, disrupt mitosis and cytokinesis, and interfere with tubulin and actin polymerization in vitro. Various markers of metabolic activity, mitotic disruption and cytokinesis were used ...
Yamauchi Takahiro T Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Fukui 910-1193, Japan. - - 2014
Background/Aim: Clofarabine is transported into leukemic cells via the equilibrative nucleoside transporters (hENT) 1 and 2 and the concentrative nucleoside transporter (hCNT) 3, then phosphorylated by deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) to an active triphosphate metabolite. Cytarabine uses hENT1 and dCK for its activation. We hypothesized that cytarabine-resistant ...
Sekine Shota S Faculty of Science, Josai University, Sakado, Saitama 350-0295, Japan. - - 2014
We newly synthesized twenty 2-aminotropones with different lengths of methylene units, with or without introduction of isopropyl group at C-4 position of the cycloheptatriene ring, which were then subjected to quantitative structure-activity relationship (QSAR) analysis. Viable cell number was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The tumor specificity was ...
Kaku Yoshiko Y Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. - - 2014
Background/Aim: The phospholipid phosphatidylethanolamine regulates a wide range of cellular processes. The present study investigated the antitumor effect of 1,2-dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (DPPE) on malignant pleural mesothelioma cells. Activities of protein phosphatases (PPs) such as PP1, PP2A, and protein tyrosine phosphatase 1B (PTP1B) were assayed under cell-free conditions. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, ...
Toyama Masaaki M Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan. - - 2014
Adult T-cell leukemia (ATL) is caused by infection with human T-cell leukemia virus type-1 (HTLV-1). The tetrahydrotetramethylnaphthalene derivative TMNAA has recently been identified as a selective inhibitor of HTLV-1-infected T-cell lines and adult T-cell leukemia (ATL) cells but not of uninfected T-cell lines and peripheral blood mononuclear cells (PBMCs). In ...
Miyake Juliano Andreoli JA Department of Cell and Developmental Biology, University of São Paulo, São Paulo, CEP 05508-900, SP, Brazil. - - 2014
Aim: Gliomas are primary brain tumours. Gamma-linolenic acid (GLA) exerts anti-proliferative effects. Several ruthenium-containing complexes have antiproliferative effects and can be used as adjuvant therapies in cisplatin-resistant cancer. The present study reports on the anti-proliferative properties and effects on tumour morphology of a novel diruthenium-GLA complex (Ru2GLA) and its comparison ...
Hamad Shahnaz A SA Discipline of Biomedical Science, School of Medical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, 75 East Street, Lidcombe, NSW 1825, Australia. - - 2014
A trinuclear platinum compound with a cis-geometry for the terminal metal centers coded as QH5 has been synthesized and investigated for activity against the human ovarian A2780, A2780(cisR) and A2780(ZD0473R) cancer cell lines. Cellular accumulation of platinum, level of platinum-DNA binding and nature of interaction of the compound with pBR322 ...
Michor Franziska F Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02215, - - 2014
Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties ...
Eckert Richard L - - 2014
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact ...
Boot Arnoud A Albinusdreef 2, 2333ZA Leiden, The Netherlands. - - 2014
Background/Aim: The potential of indolizine derivatives as anticancer agents has been shown through recent studies. Herein, we present our experimental results, showing that pyrido[2,3-b]indolizine derivatives are effective against colorectal cancer (CRC) cell lines. Several pyrido[2,3-b]indolizine derivatives were synthesized and their anticancer potential was evaluated against three CRC cell lines and ...
Cha Wonjae W Seoul National University Hospital, 101 Daehakro, Jongno-gu, Seoul 110-744, Korea. - - 2014
We investigated whether the endoplasmic reticulum (ER) stress response could be a cyclooxygenase-2 (COX2)-independent mechanism of growth inhibition by celecoxib in a head and neck squamous cell carcinoma (HNSCC) cell line. We performed western blotting and reverse transcription polymerase chain reaction to analyze the expression of ER stress response-associated proteins ...
Spengler Gabriella G Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. - - 2014
Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity. A series of new phenothiazine derivatives was investigated regarding their ABCB1-modulating effect on multidrug resistant mouse T-lymphoma cells by rhodamine ...
Lai Cheng-Kuo CK Chaoyang University of Technology, Taichung, Taiwan, R.O.C. Tel: +886 423323000 ext. 4471, - - 2014
Background/Aim: The current study aimed to identify an attractive target against human oral squamous cell carcinoma (OSCC). The effect of 3,3',4',5'-tetramethoxychalcone (TMC) on OSCC cell proliferation, cell-cycle phase distribution, expression of markers of cell apoptosis, and cell migration were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, western blot, and transwell ...
Iida Shinya S Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan. - - 2014
Background/Aim: AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC. We first immunolocalized the phosphorylated form of AXL in 112 lung adenocarcinoma cases and subsequently evaluated the anti-neoplastic effects of monoclonal antibody ...
Choi Yong-Ji YJ Department of Biotechnology and Bioengineering, Chonnam National University, Gwangju 500-757, South Korea. - - 2014
Deinoxanthin is unique carotenoid isolated from the radioresistant bacterium Deinococcus radiodurans. In the present study, the induction of apoptosis of cancer cells by deinoxanthin was investigated. Apoptotic effects were evaluated in HepG2, PC-3, and HT-29 cells, and were measured through cell viability, morphological changes, and a DNA fragmentation assay. Intracellular ...
Figueiró Fabrício F Ramiro Barcelos Street, 2600 Lab 22, Zip code: 90035-003, Porto Alegre/RS. - - 2014
Background/Aim: Glioblastoma multiforme is the most malignant type of glioma. Ecto-5'-nucleotidase (ecto-5'NT), a glioma-overexpressed enzyme can induce a protective effect on tumor cells. Monastrol, a kinesin spindle protein-specific inhibitor, is reported to be an interesting prototype for cancer therapy. We describe the effect of LaSOM 63, a monastrol derivative, on ...
Jasek Ewa E Department of Histology, Jagiellonian University Medical College, Kopernika 7, PL-31034 Krakow, Poland. - - 2014
Poly (ADP-ribose) polymerase (PARP) inhibitors and histone deacetylase (HDAC) inhibitors are new promising anticancer drugs. The aim of the present study was to investigate the effect of combination treatment with PARP inhibitor PJ34 and HDAC inhibitor vorinostat on human leukemia cell lines. Proliferation, apoptosis, mitochondrial membrane potential (ψm) and cell ...
Chiablaem Khajeelak K Laboratory of Biochemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6, Talat Bang Khen, Laksi, Bangkok 10210, Thailand. - - 2014
Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human hepatocellular carcinoma (HCC) cells. In vitro VM, cell migration, and ...
Sudan Sudhanshu S Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O Box 550, Truro, Nova Scotia B2N 5E3, Canada. - - 2014
Dietary flavonoids have been associated with reduced risk of cancer including hepatocellular carcinoma (HCC). Quercetin-3-O-glucoside (Q3G) has been shown to possess anti-proliferative and antioxidant activities. The objectives of this study were to assess the anti-proliferative properties of Q3G in human liver cancer cells (HepG2); assess the cytotoxicity on normal primary ...
Chen Chen C Graduate School of Health and Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Johnan-ku, Fukuoka, Fukuoka 814-0198, Japan. - - 2014
Although nobiletin has a potent antitumor activity against several types of human cancers, its inhibitory effects and possible mechanisms of action on breast cancer cells with different hormone receptor and HER2 status remains unknown. Using hormone receptor-positive MCF-7, HER2-positive SK-BR-3, and triple-negative MDA-MB-468 cell lines, we investigated the antitumor mechanisms ...
Iwen Ka K Department of Internal Medicine I, University of Lübeck, Lübeck, - - 2014
Human adipose-derived stroma cells (ADSCs) have successfully been employed in explorative therapeutic studies. Current evidence suggests that ADSCs are unevenly distributed in subcutaneous adipose tissue; therefore, the anatomic origin of ADSCs may influence clinical outcomes. This study was designed to investigate proliferation and differentiation capacities of ADSCs from the gluteal ...
Stata Matt M Department of Ecology and Evolutionary Biology, The University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S3B2, - - 2014
The evolution of C4 photosynthesis from C3 ancestors eliminates the RuBP carboxylation function in the mesophyll (M) cell chloroplast while activating PEP carboxylation in the cytosol. These changes may lead to fewer chloroplasts and different chloroplast positioning within M cells. To evaluate these possibilities, we compared chloroplast number, size and ...
Palumbo Silvia S Department of Biology and Biotechnology, University of Pavia, Pavia, - - 2014
Glioblastoma (GBM) remains the most aggressive and lethal brain tumor due to its molecular heterogeneity and high motility and invasion capabilities of its cells, resulting in high resistance to current standard treatments (surgery, followed by ionizing radiation combined with Temozolomide chemotherapy administration). Locus amplification, gene overexpression, and genetic mutations of ...
Tima Singkome S Nanoscience and Nanotechnology Program, Faculty of Graduate School, Chiang Mai University , Chiang Mai 50200, - - 2014
Leukemia is a hematologic malignancy with a frequent incidence and high mortality rate. Previous studies have shown that the FLT3 gene is overexpressed in leukemic blast cells, especially in acute myeloid leukemia. In this study, a commercially available curcuminoid mixture (1), pure curcumin (2), pure demethoxycurcumin (3), and pure bisdemethoxycurcumin ...
Del Debbio Carolina Beltrame CB Cell and Developmental Biology, University of Sao Paulo, Biomedical Sciences Institute, Sao Paulo, 05508-000, - - 2014
Purpose:Rho GTPases play a central role in actin-based cytoskeleton reorganization, and regulate multiple signaling pathways that control gene transcription, cell survival and proliferation. We investigated the effect of Rho GTPases on cell cycle regulation and progenitor genes expression on mouse ciliary epithelium (CE), a potential source of progenitor/stem cells in ...
Bird April M - - 2014
For animal cells, ciliation and mitosis appear to be mutually exclusive. While uniciliated cells can resorb their cilium to undergo mitosis, multiciliated cells apparently can never divide again. Nevertheless, many multiciliated epithelia in animals must grow or undergo renewal. The larval epidermis in a number of marine invertebrate larvae, such ...
Karlupia Neha - - 2014
Stroke is the second leading cause of death worldwide, claims six lives every 60 seconds and is a leading cause of adult disability across the globe. Tissue plasminogen activator, the only United States Food and Drug Administration (FDA)-approved drug currently available, has a narrow therapeutic time window of less than ...
van Embden Joel J CSIRO Materials Science and Engineering , Bayview Avenue, Clayton, Victoria 3168, - - 2014
A facile ligand exchange method for dispersing Cu2ZnSnS4 (CZTS) nanocrystals (NCs) in environmentally benign polar solvents, such as ethanol or n-propanol, at high concentrations (up to 200 mg/mL) is demonstrated. This approach has been applied to CZTS nanocrystals synthesized via scalable, noninjection methods to formulate colloidally stable inks that are ...
Sardar Adam J AJ Department of Computer Science, University of Bristol, Bristol, United - - 2014
Humans are composed of hundreds of cell types. As the genomic DNA of each somatic cell is identical, cell type is determined by what is expressed and when. Until recently, little has been reported about the determinants of human cell identity, particularly from the joint perspective of gene evolution and ...
Huang Chuixiu - - 2014
In this work, a simple breath figure method was proposed to directly fabricate large-area and ordered honeycomb structures on commercial PMMA substrates or PS Petri dishes without use of an external polymer solution. The obtained honeycomb structure is indeed part of the substrate, providing the honeycomb layer with enough mechanical ...
Lee Benjamin E BE The Daniel and Gloria Blumenthal Cancer Center, Paramus, New Jersey; The Division of Thoracic Surgery, Department of Surgery, The Valley Hospital/Valley Health System, Ridgewood, New Jersey. Electronic address: - - 2014
Follicular dendritic cell sarcoma is a rare malignant neoplasm of immune accessory follicular dendritic cells and may be associated with Castleman's disease which is a known precursor to follicular dendritic cell sarcomas. We report a case of a follicular dendritic cell sarcoma arising in Castleman's disease in a 63-year-old man ...
Liu Ran - - 2014
Embryonic stem (ES) cells are an important factor in the development of cell-based therapeutic strategies. In this work, the use of digital holographic interferometric microscopy and statistical identification for automatic discrimination of ES cells and fibroblast (FB) cells is discussed in detail. The proposed algorithm first reduces the complex data ...
Hatori Yasuhiro - - 2014
Construction of surface is a crucial step toward the representation of shape through the integration of local information. Physiological studies have reported that the primary visual cortex (V1) codes the medial axis (MA) that is a skeletal structure equidistant from nearby contours, suggesting the early representation of surface in V1. ...
Aoki Takeshi T From the Divisions of *Hepato-Biliary-Pancreatic Surgery, and †Integrated Surgery and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan; ‡Division of International Cooperation for Disaster Medicine, International Research Institute of Disaster Science, Tohoku University, Aobaku, Sendai, Japan; and §Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Suita, Osaka, - - 2014
Although the somatostatin analog octreotide (OCT) has been used for uncontrollable insulinoma, the mechanism involved is still unknown. The aim of this study was to elucidate the therapeutic effect of OCT for insulinoma. Mouse insulinoma cell line MIN6 cells were cultured with OCT to clarify its antiproliferative effects, the expression ...
Kissei Maika M School of Pharmacy, Kitasato - - 2014
  Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT). In the present study, we investigated whether epigallocatechin gallate (EGCG), one of the tea catechins, affects the transport of FA by PCFT. EGCG inhibited the uptake of ...
Yu Xiao X University of South Florida, Department of Physics, Digital Holography and Microscopy Laboratory, Tampa, Florida - - 2014
ABSTRACT. Three-dimensional profiling and tracking by digital holography microscopy (DHM) provide label-free and quantitative analysis of the characteristics and dynamic processes of objects, since DHM can record real-time data for microscale objects and produce a single hologram containing all the information about their three-dimensional structures. Here, we have utilized DHM ...
Yang Gui G ENT Institute of Shenzhen University, Shenzhen, China; Longgang Central Hospital, Shenzhen ENT Institute, - - 2014
The functions of regulatory T (Treg) cells are important in immunity, and the regulatory mechanisms of Treg cell activities are not fully understood yet. We sought to investigate the role of insulin-like growth factor (IGF) 2 in the upregulation of Treg cell function. The expression of insulin-like growth factor 2 ...
Holmes William R WR Center for Mathematical and Computational Biology, Center for Complex Biological Systems, Department of Mathematics, University of California, Irvine, - - 2014
Regeneration of central nervous system (CNS) lesions requires movement of progenitor cells and production of their differentiated progeny. Although damage to the CNS clearly promotes these two processes, the interplay between these complex events and how it affects a response remains elusive. Here, we use spatial stochastic modeling to show ...
Kaliman Sara S Institute for Theoretical Physics and Cluster of Excellence: Engineering of Advanced Materials, University Erlangen-Nürnberg, - - 2014
It is well established that MDCK II cells grow in circular colonies that densify until contact inhibition takes place. Here, we show that this behavior is only typical for colonies developing on hard substrates and report a new growth phase of MDCK II cells on soft gels. At the onset, ...
Lumelsky Nadya N Tissue Engineering and Regenerative Medicine Research Program, Integrative Biology and Infectious Disease Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6701 Democracy Boulevard, Bethesda, MD 20892-4878, USA. Electronic address: - - 2014
Obtaining large numbers of functional pancreatic islets via direct cellular reprogramming is an important clinically relevant goal. In a recent issue of Cell Stem Cell, Li et al. (2014) report a new step-wise protocol for generating islet cells from mouse embryonic fibroblasts using a combination of soluble molecules.
Manosroi Aranya A Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, (phone: +66-53-944338; fax: - - 2014
Six new limonoids, 7-benzoyl-17-epinimbocinol (5), 3-acetyl-7-tigloylnimbidinin (8), 1-isovaleroyl-1-detigloylsalanninolide (15), 2,3-dihydro-3α-methoxynimbolide (16), deacetyl-20,21-epoxy-20,22-dihydro-21-deoxyisonimbinolide (26), and deacetyl-20,21,22,23-tetrahydro-20,22-dihydroxy-21,23-dimethoxynimbin (27), along with 28 known limonoids, 1-4, 6, 7, 9-14, 17-25, and 28-34, and two known flavonoids, 35 and 36, have been isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica ...
Wade Alexander J AJ EW Group, Platts Lane, Old Moss, Stapleford, Tarvin, Chester, CH3 8HR, United - - 2014
Diseases such as avian influenza can destroy turkey flocks, potentially resulting in the loss of valuable or rare genetic material. Consequently, there is an urgent need to develop a means to archive such germplasm. Germline chimeras produced by intravascular transfer of primordial germ cells (PGC) have been reported in other ...
Tao Li L State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, - - 2014
Non-genetic phenotypic variations play a critical role in the adaption to environmental changes in microbial organisms. Candida albicans, a major human fungal pathogen, can switch between several morphological phenotypes. This ability is critical for its commensal lifestyle and for its ability to cause infections. Here, we report the discovery of ...
Eisenach Cornelia C Institute of Plant Biology, University of Zürich, Zollikerstrasse 107, CH-8008 Zürich, Switzerland. Electronic address: - - 2014
Petunia flower colour is dependent on vacuolar pH and is therefore used to study acidification mechanisms. Recently, it was shown that the concerted action of two tonoplast-localised P3-ATPases is required to hyperacidify vacuoles of petunia petal epidermis cells. Here we discuss how steep cross-tonoplast pH gradients may be established in ...
Preechaburana Pakorn P Department of Physics, Faculty of Science and Technology, Thammasat University, Pathumthani 12121, - - 2014
Continued progress in cell-phone devices has made them powerful mobile computers, equipped with sophisticated, permanent physical sensors embedded as the default configuration. By contrast, the incorporation of permanent biosensors in cell-phone units has been prevented by the multivocal nature of the stimuli and the reactions involved in biosensing and chemical ...
Harman James G JG Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas - - 2014
A typical clinical cis-diamminedichloroplatinum (II) (cisplatin) dosing regimen consists of repeated treatment cycles followed by a recovery period. While effective, this dosing structure results in a prolonged, often permanent, infertility in men. Spermatogonial stem cells (SSCs) are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. We propose ...
Morán María M Mitochondrial and Neuromuscular Diseases Laboratory, Hospital Universitario 12 de Octubre Research Institute (i+12), Madrid, Spain; Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain. Electronic address: - - 2014
Oxidative phosphorylation system (OXPHOS) deficiencies are rare diseases but constitute the most frequent inborn errors of metabolism. We analyzed the autophagy route in 11 skin fibroblast cultures derived from patients with well characterized and distinct OXPHOS defects. Mitochondrial membrane potential determination revealed a tendency to decrease in 5 patients' cells ...
Li Lian L Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, PR - - 2014
Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to be accessible to its ...
Gui Meng-Cui MC Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, - - 2014
Autophagy dysregulation, mitochondrial dynamic abnormality and cell cycle re-entry are implicated in the vulnerable neurons of patients with Alzheimer's disease. This study was designed to testify the association among autophagy, mitochondrial dynamics and cell cycle in dividing neuroblastoma (N2a) cells. The N2a cells were cultured in vitro and treated with ...
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