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Results 301 - 350 of 30359
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De Rybel Bert B Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703HA Wageningen, the - - 2014
Coordination of cell division and pattern formation is central to tissue and organ development, particularly in plants where walls prevent cell migration. Auxin and cytokinin are both critical for division and patterning, but it is unknown how these hormones converge upon tissue development. We identify a genetic network that reinforces ...
Bae Joonbeom J Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-701, Republic of - - 2014
Lymphocyte activation gene-3 (LAG-3; CD223), a structural homolog of CD4, binds to MHC class II molecules. Recent research indicated that signaling mediated by LAG-3 inhibits T cell proliferation, and LAG-3 serves as a key surface molecule for the function of regulatory T cells. Previous reports demonstrated that the majority of ...
Song Guiyun G Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, - - 2014
Clofarabine (Clo), fludarabine (Flu), and busulfan (Bu) are used in pre-transplant conditioning therapy for patients with myeloid leukemia. To further improve their efficacy in FLT3-ITD-positive AML, we investigated their synergism with sorafenib (Sor). Exposure of FLT3-ITD-positive MV-4-11 and MOLM 13 cells to [Bu+Clo+Flu+Sor] resulted in synergistic cytotoxicity; no such synergism ...
Chen B B Department of Urology and Chawnshang Chang Liver Cancer Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
Docetaxel-based therapy is one of the first-line options for castration-resistant prostate cancer (CRPC). However, a large proportion of CRPC patients show different extents of docetaxel resistance. The current study aims to investigate the role of testicular nuclear receptor 4 (TR4) in docetaxel resistance in CRPC. TR4 expression level in prostate ...
de Groot Martje W G D M MW Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL 3508 TD Utrecht, The Netherlands. Electronic address: - - 2014
Increasing exposure to extremely low frequency electromagnetic fields (ELF-EMF), generated by power lines and electric appliances, raises concern about potential adverse health effects of ELF-EMF. The central nervous system is expected to be particularly vulnerable to ELF-EMF as its function strongly depends on electrical excitability. We therefore investigated effects of ...
Cápiro Natalie L - - 2014
Contemporary microbial monitoring of aquifers relies on groundwater samples to enumerate non-attached cells of interest. One-dimensional column studies quantified the distribution of bacterial cells in solid and the aqueous phases as a function of microbial species, growth substrate availability and porous medium (i.e., Appling soil versus Federal Fine Ottawa sand ...
Matharu Zimple - - 2014
We developed cell-culture/biosensor platform consisting of aptamer-modified Au electrodes integrated with reconfigurable microfluidics for monitoring of TGF-β1 - an important inflammatory and pro-fibrotic cytokine. Aptamers were thiolated, labeled with redox reporters and self-assembled on gold surfaces. The biosensor was determined to be specific for TGF-β1 with experimental detection limit of ...
Gires Olivier O Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany, - - 2014
Formation of metastasis is the most important and lethal step in cancer progression. Circulating and disseminated cancer cells (CTCs/DTCs) in blood and bone marrow are considered as potential metastases-inducing cells. Their detection and characterization has, therefore, become a field of major interest in translational and clinical research in oncology. The ...
Kim Seong Chul SC The Ohio State - - 2014
The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. ...
Nisenholz Noam N Institute of Dental Sciences and Fritz Haber Center for Molecular Dynamics, Hebrew University of Jerusalem, 91120, Israel. - - 2014
The spreading area of cells has been shown to play a central role in the determination of cell fate and tissue morphogenesis; however, a clear understanding of how spread cell area is determined is still lacking. The observation that cell area and force generally increase with substrate rigidity suggests that ...
Li Yan Y Department of Obstetrics and Gynaecology, Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z - - 2014
Context: Inhibin β subunits and activin receptors are expressed by human trophoblast cells. Though activin A has been shown to enhance human trophoblast cell invasion, whether two additional activin isoforms, activin B and AB, exert similar effects remains unknown. Moreover, whether the expression of mesenchymal adhesion molecule neural cadherin (N-cadherin) ...
Liu Yonghua Y Department of Pathogen Biology, Medical College, Nantong University, Nantong, 226001, Jiangsu, People's Republic of - - 2014
Histone deacetylase 4 (HDAC4), a member of the class IIa HDACs subfamily, has emerged as a critical regulator of cell growth, differentiation, and migration in various cell types. It was reported that HDAC4 stimulated colon cell proliferation via repression of p21. Also, HDAC4 contributes to platelet-derived growth factor-BB-induced proliferation and ...
Lucía Zarzosa Ana A Center for Regenerative Therapies Dresden (CRTD), Technische Universität, Dresden, Fetscherstrasse 105, 01307 Dresden, - - 2014
How animals adjust the size of their organs is a fundamental, enduring question in biology. Here we manipulate the amount of neural crest (NC) precursors for the dorsal root ganglia (DRG) in axolotl. We produce embryos with an under- or over-supply of pre-migratory NC in order to find out if ...
Cerrone Federico F School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, - - 2014
A mathematically based fed-batch bioprocess demonstrated the suitability of using a relatively cheap and renewable substrate (butyric acid) for Pseudomonas putida CA-3 high cell density cultivation. Butyric acid fine-tuned addition is critical to extend the fermentation run and avoid oxygen consumption while maximising the biomass volumetric productivity. A conservative submaximal ...
Gerhardt Matthias - - 2014
The membrane and actin cortex of a motile cell can autonomously differentiate into two states, one typical of the front, the other of the tail. On the substrate-attached surface of Dictyostelium cells, dynamic patterns of front-like and tail-like states are generated that are best suited to monitor transitions between these ...
Zajkoska Petra P Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, - - 2014
This work demonstrates the first example of the immobilisation of MAO-N whole cells to produce a biocatalyst that remained suitable for repetitive use after 11 months of storage and stable up to 15 months after immobilisation. The production of Escherichia coli expressing recombinant MAO-N was scaled up to bioreactors under regulated, previously ...
Garvican Elaine R - - 2014
Autologous mesenchymal stem cell (MSC) injection into naturally-occurring equine tendon injuries has been shown to be safe and efficacious and protocols inform translation of the technique into humans. Efficient transfer of cells from the laboratory into tissue requires well-validated transport and implantation techniques. Cell viability in a range of media ...
Nagai Yu Y 1 Department of Orthopedic Surgery, Surugadai Nihon University Hospital , Tokyo, Japan - - 2014
Abstract Objective: The purpose of this study was to investigate the effectiveness of photodynamic therapy (PDT) with Na-pheophorbide A in anticancer treatment, using osteosarcoma cells in vitro. Background data: It has been reported that PDT with chlorophyll derivatives inhibits the proliferation of various cancer cells. However, there have been no ...
Jang Wooyoung W Department of Neurology, Hanyang University College of Medicine, Seoul, South - - 2014
The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxyvitamin D3 (calcitriol) on L-DOPA-induced NSC ...
Hu Yan-Jian YJ Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. - - 2014
Tumor invasion and metastasis are the main causes of mortality in patients with hepatocellular carcinoma (HCC). Thus, the effective inhibition of these tumorigenic processes is critical in order for HCC therapy to be effective. Previous studies have demonstrated that Notch1 is associated with metastasis in several human malignancies. However, the ...
Guan Tao - - 2014
Overlapping cells segmentation is one of the challenging topics in medical image processing. In this paper, we propose to approximately represent the cell contour as a set of sparse contour points, which can be further partitioned into two parts: the strong contour points and the weak contour points. We consider ...
Luca T T Fondazione Mediterranea "G.B. Morgagni", 95125, Catania, - - 2014
Overexpression or constitutive activation of epidermal growth factor receptors (EGFR) is involved in growth of human cancers. We investigated effects of EGFR and HER-2 blockade in colon cancer cell lines using cetuximab and trastuzumab, with the aim of developing novel approaches to cancer therapy. We studied effects of treatment on ...
Nair Nishanth Ulhas - - 2014
In cell differentiation, a cell of a less specialized type becomes one of a more specialized type,even though all cells have the same genome. Transcription factors and epigenetic marks like histonemodifications can play a significant role in the differentiation process. In this paper, we present a simple analysis of cell ...
Eldhose Binil B School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala-686560, - - 2014
Despite increased use of early detection methods and more aggressive treatment strategies, the worldwide incidence of colorectal cancer is still on the rise. Consequently, it remains urgent to identify novel agents with enhanced efficacy in prevention and/or therapeutic protocols. Our studies focused on the use of Plumbagin, a natural phytochemical ...
Elias Silvia T ST Faculty of Health Sciences, University of Brasília, SQN 205, bloco H apto 201, Asa Norte, Brasilia, DF, 70843-080, - - 2014
Antineoplastic effects of molecules derived from plants have recently gained increasing attention as an additive to traditional therapies. The aim of this study was to evaluate the cytotoxic activity of plant extracts from the Brazilian Cerrado biome associated with radiotherapy in head and neck carcinoma cells (HNSCC). Fifteen extracts derived ...
Buchheit Cassandra L CL 1] Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. - - 2014
Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial cells must adapt to and survive in the absence of ECM. During the past 20 years, several cellular changes, including anoikis, have been shown to regulate cell viability when cells become ...
da Rosa Marina Rolo Pinheiro MR Department of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Pará-UFPA, Belém, - - 2014
Ameloblastoma is an odontogenic tumor characterized by local invasiveness and frequent recurrence. The surrounding stroma, composed of different cell types and extracellular matrix (ECM), may influence ameloblastoma invasive behavior. Furthermore, tumor and stromal cells secrete matrix metalloproteases (MMPs), which, in turn, can modulate the matrix and promote the release of ...
Fan Yibo Y Department of Medical Oncology, The First Hospital of China Medical University, No.155, North Nanjing Street, Heping District, Shenyang, 110001, - - 2014
Trypsin is a digestive enzyme that is widely used for cell detachment, which is the first stage of tumor metastasis. Recent studies show that adhesion-related kinases are involved in cell detachment. Proline-rich tyrosine kinase 2 (Pyk2) is a crucial kinase in the regulation of cell adhesion and detachment. However, the ...
Rivas Eva-María EM CEI Campus Moncloa, UCM-UPM, Madrid, Spain; Departamento de Microbiología III. Facultad de Biología, Universidad Complutense de Madrid, C/ José Antonio Nováis, 2, 28040, Madrid, - - 2014
We propose a model, based on the Gompertz equation, to describe the growth of yeasts colonies on agar medium. This model presents several advantages: i) one equation describes the colony growth which previously needed two separate ones (linear increase of radius and of the squared radius); ii) a similar equation ...
Gong Maogang - - 2014
Single-walled carbon nanotubes (SWCNTs) have highly desirable attributes for solution-processable thin-film photovoltaics (TFPVs), such as broadband absorption, high carrier mobility, and environmental stability. However, previous TFPVs incorporating photoactive SWCNTs have utilized architectures that have limited current, voltage, and ultimately power conversion efficiency (PCE). Here, we report a solar cell geometry ...
Philippa Bronson B College of Science, Technology and Engineering, James Cook University, Townsville 4811, - - 2014
Charge carrier recombination is studied in operational organic solar cells made from the polymer:fullerene system PCDTBT:PC71BM (poly[N-9(') (')-heptadecanyl-2,7-carbazole-alt-5,5-(4('),7(')-di-2-thienyl-2('),1('),3(')-benzothiadiazole)]: [6,6]-phenyl-C70-butyric acid methyl ester). A newly developed technique High Intensity Resistance dependent PhotoVoltage is presented for reliably quantifying the bimolecular recombination coefficient independently of variations in experimental conditions, thereby resolving key limitations ...
Winzi Maria M University Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, - - 2014
Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.
Cao Xu - - 2014
Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences show that hTERT is essential for neoplastic transformation independent of its canonical function. However, the roles of hTERT in the process remain elusive. ...
He Wei-Ling WL Wei-Ling He, Shi-Rong Cai, Wu Song, Chang-Hua Zhang, Yu-Long He, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, - - 2014
To explore the efficacy of PCI-24781, a broad-spectrum, hydroxamic acid-derived histone deacetylase inhibitor, in the treatment of gastric cancer (GC). With or without treatment of PCI-24781 and/or cis-diamminedichloroplatinum (CDDP), GC cell lines were subjected to functional analysis, including cell growth, apoptosis and clonogenic assays. Chromatin immunoprecipitation and luciferase reporter assays ...
Zhai Hui-Hong HH Hui-Hong Zhai, Juan Meng, Department of Digestive Diseases, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, - - 2014
To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer cell lines that had been either unstimulated or ...
Zhang Qing-Yu QY Qing-Yu Zhang, Ran Li, Guo-Fang Zeng, Bin Liu, Jie Liu, Yang Shu, Zhong-Kao Liu, Zhi-Dong Qiu, Dong-Jun Wang, Hui-Lai Miao, Ming-Yi Li , Run-Zhi Zhu, Key Laboratory of Hepatic Disease, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, - - 2014
To investigate the effects of dihydromyricetin (DHM) on the migration and invasion of human hepatic cancer cells. The hepatoma cell lines SK-Hep-1 and MHCC97L were used in this study. The cells were cultured in RPIM-1640 medium supplemented with 10% fetal bovine serum at 37 °C in a humidified 5% CO2 incubator. ...
Leroux Brian M BM Department of Biology, Central Michigan University, Mount Pleasant, Michigan 48859 - - 2014
• Premise of the study: Given the worldwide economic importance of maize endosperm, it is surprising that its development is not the most comprehensively studied of the cereals. We present detailed morphometric and cytological descriptions of endosperm development in the maize inbred line B73, for which the genome has been ...
Evans Stephanie K SK University of Glasgow, United - - 2014
The Target of Rapamycin Complex 1 (TORC1) is a key and conserved regulator of eukaryotic cell growth. The xenobiotic rapamycin is a potent inhibitor of the yeast complex. Surprisingly, the EGO complex, a non-essential in vivo activator of TORC1, is somehow required for yeast cells to recover efficiently from a ...
Madonna Rosalinda R Heart Failure Research, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, TX, USA; Institute of Cardiology, Department of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, - - 2014
Background and objective: Hyperglycemia leads to adaptive cell responses in part due to hyperosmolarity. In endothelial and epithelial cells, hyperosmolarity induces aquaporin-1 (AQP1) which plays a role in cytoskeletal remodeling, cell proliferation and migration. Whether such impairments also occur in human induced pluripotent stem cells (iPS) is not known. We ...
Santa Maria John P JP Jr Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA - - 2014
Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundant roles in regulating cell division. To gain insight into the underlying biology of S. aureus TAs, we used a small molecule inhibitor to screen a highly saturated ...
Deng Yingtian Y Wuhan - - 2014
In the life cycle of flowering plants, the sporophytic generation takes up most of the time and plays a dominant role in influencing plant growth and development. The embryo cell and endosperm free-nucleus divisions establish the critical initiation phase of early sporophyte development, which forms mature seeds through a series ...
Nuñez Ortiz N N Dipartimento per l'Innovazione nei Sistemi Biologici Agroalimentari e Forestali, Università della Tuscia - - 2014
The gills of fish are a mucosal tissue that contains T cells involved in the recognition of non-self and pathogens, and in this work we describe some features of gill-associated T cells of European sea bass, a marine model species. A whole transcriptome was obtained by deep sequencing of RNA ...
Bastos Lilian Gonçalves Dos Reis LG Cellular Biology Program, Brazilian National Cancer Institute (INCA), 37André Cavalcanti Street, 5th Floor, Rio de Janeiro, RJ, Brazil, - - 2014
Radiotherapy remains a major approach to adjuvant therapy for patients with advanced colorectal cancer and the fractionation schedules frequently allow for the repopulation of surviving tumors cells, neoplastic progression, and subsequent metastasis. The aim of the present study was to analyze the transgenerational effects induced by radiation and evaluate whether ...
Chaabane Chiraz C Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, - - 2014
It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant number of ...
Mello Paola de Andrade PD Laboratory of Biochemical and Cytological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, - - 2014
In cervical cancer, HPV infection and disruption of mechanisms involving cell growth, differentiation and apoptosis are strictly linked with tumor progression and invasion. Tumor microenvironment is ATP and adenosine rich, suggesting a role for purinergic signaling in cancer cell growth and death. Here we investigated the impact of extracellular ATP ...
Mohan Shalini S a Plant Biotechnology Division, School of Bio Sciences and Technology, VIT University , Vellore 632 014 , Tamil Nadu , - - 2014
Although some polyphenols are known to possess anticancer activity against different cancer cell lines through induction of apoptosis, the mode of antiproliferative effect of ethyl gallate against human oral squamous carcinoma cell line KB was not studied until now. Therefore, the antiproliferative effect of ethyl gallate was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...
Casarin Elisabetta E Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, - - 2014
A different behavior of the two dibenzocyclooctadiene lignans (+)-deoxyschisandrin (1) and (-)-gomisin N (2), from Schisandra chinensis fruits, was observed against two human tumour cell lines, (2008 and LoVo). These lignans inhibited cell growth in a dose-dependent manner on both cell lines, but inducing different types of cell death. In ...
Clarke Rachel R Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Northern Ireland, United Kingdom. Electronic address: - - 2014
Aflatoxin B1 (AFB1), ochratoxin A (OTA) and fumonisin B1 (FB1) are contaminants which have been shown to regularly co-occur in a range of foods. However, only a small number of studies have evaluated the interactive effect of binary and tertiary mycotoxins. The present study evaluated the effects of low levels ...
Pan Jie-Hong JH Departments of Medicine, Washington University, Saint Louis, MO, 63110, - - 2014
The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63(+) basal epithelial progenitor cell generates a ciliated or secretory cell ...
Penthala Narsimha R NR Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, - - 2014
(E)-13-(Aryl/heteroaryl)parthenolides (5a-i and 6a-i) were synthesized and evaluated for their ability to modify cell cycle progression during progesterone-stimulated Xenopus oocyte maturation and screened for their anticancer activity against a panel of 60 human cancer cell lines. (E)-13-(4-aminophenyl) parthenolide (5b) caused a significant inhibition of progesterone-stimulated oocyte maturation, and was determined ...
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