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Gong Maogang - - 2014
Single-walled carbon nanotubes (SWCNTs) have highly desirable attributes for solution-processable thin-film photovoltaics (TFPVs), such as broadband absorption, high carrier mobility, and environmental stability. However, previous TFPVs incorporating photoactive SWCNTs have utilized architectures that have limited current, voltage, and ultimately power conversion efficiency (PCE). Here, we report a solar cell geometry ...
Philippa Bronson B College of Science, Technology and Engineering, James Cook University, Townsville 4811, - - 2014
Charge carrier recombination is studied in operational organic solar cells made from the polymer:fullerene system PCDTBT:PC71BM (poly[N-9(') (')-heptadecanyl-2,7-carbazole-alt-5,5-(4('),7(')-di-2-thienyl-2('),1('),3(')-benzothiadiazole)]: [6,6]-phenyl-C70-butyric acid methyl ester). A newly developed technique High Intensity Resistance dependent PhotoVoltage is presented for reliably quantifying the bimolecular recombination coefficient independently of variations in experimental conditions, thereby resolving key limitations ...
Winzi Maria M University Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, - - 2014
Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.
Cao Xu - - 2014
Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomesase, is responsible for telomere maintenance and its reactivation is implicated in almost 90% human cancers. Recent evidences show that hTERT is essential for neoplastic transformation independent of its canonical function. However, the roles of hTERT in the process remain elusive. ...
He Wei-Ling WL Wei-Ling He, Shi-Rong Cai, Wu Song, Chang-Hua Zhang, Yu-Long He, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, - - 2014
To explore the efficacy of PCI-24781, a broad-spectrum, hydroxamic acid-derived histone deacetylase inhibitor, in the treatment of gastric cancer (GC). With or without treatment of PCI-24781 and/or cis-diamminedichloroplatinum (CDDP), GC cell lines were subjected to functional analysis, including cell growth, apoptosis and clonogenic assays. Chromatin immunoprecipitation and luciferase reporter assays ...
Zhai Hui-Hong HH Hui-Hong Zhai, Juan Meng, Department of Digestive Diseases, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, - - 2014
To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis. The expression of CacyBP/SIP protein in gastric cancer cell lines was detected by Western blot. Immunofluorescence experiments were performed on gastric cancer cell lines that had been either unstimulated or ...
Zhang Qing-Yu QY Qing-Yu Zhang, Ran Li, Guo-Fang Zeng, Bin Liu, Jie Liu, Yang Shu, Zhong-Kao Liu, Zhi-Dong Qiu, Dong-Jun Wang, Hui-Lai Miao, Ming-Yi Li , Run-Zhi Zhu, Key Laboratory of Hepatic Disease, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, - - 2014
To investigate the effects of dihydromyricetin (DHM) on the migration and invasion of human hepatic cancer cells. The hepatoma cell lines SK-Hep-1 and MHCC97L were used in this study. The cells were cultured in RPIM-1640 medium supplemented with 10% fetal bovine serum at 37 °C in a humidified 5% CO2 incubator. ...
Leroux Brian M BM Department of Biology, Central Michigan University, Mount Pleasant, Michigan 48859 - - 2014
• Premise of the study: Given the worldwide economic importance of maize endosperm, it is surprising that its development is not the most comprehensively studied of the cereals. We present detailed morphometric and cytological descriptions of endosperm development in the maize inbred line B73, for which the genome has been ...
Evans Stephanie K SK University of Glasgow, United - - 2014
The Target of Rapamycin Complex 1 (TORC1) is a key and conserved regulator of eukaryotic cell growth. The xenobiotic rapamycin is a potent inhibitor of the yeast complex. Surprisingly, the EGO complex, a non-essential in vivo activator of TORC1, is somehow required for yeast cells to recover efficiently from a ...
Madonna Rosalinda R Heart Failure Research, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, TX, USA; Institute of Cardiology, Department of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, - - 2014
Background and objective: Hyperglycemia leads to adaptive cell responses in part due to hyperosmolarity. In endothelial and epithelial cells, hyperosmolarity induces aquaporin-1 (AQP1) which plays a role in cytoskeletal remodeling, cell proliferation and migration. Whether such impairments also occur in human induced pluripotent stem cells (iPS) is not known. We ...
Santa Maria John P JP Jr Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA - - 2014
Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundant roles in regulating cell division. To gain insight into the underlying biology of S. aureus TAs, we used a small molecule inhibitor to screen a highly saturated ...
Deng Yingtian Y Wuhan - - 2014
In the life cycle of flowering plants, the sporophytic generation takes up most of the time and plays a dominant role in influencing plant growth and development. The embryo cell and endosperm free-nucleus divisions establish the critical initiation phase of early sporophyte development, which forms mature seeds through a series ...
Peng Gang G Department of Head and Neck Cancer, Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. - - 2014
The primary treatment for nasopharyngeal carcinoma (NPC) is radiotherapy, with or without concurrent chemotherapy. However, resistance to radiotherapy is not uncommon. The aim of the present study was to establish a radioresistant NPC cell line to study the molecular mechanisms of radioresistance by measuring the expression of cell cycle control ...
Nuñez Ortiz N N Dipartimento per l'Innovazione nei Sistemi Biologici Agroalimentari e Forestali, Università della Tuscia - - 2014
The gills of fish are a mucosal tissue that contains T cells involved in the recognition of non-self and pathogens, and in this work we describe some features of gill-associated T cells of European sea bass, a marine model species. A whole transcriptome was obtained by deep sequencing of RNA ...
Bastos Lilian Gonçalves Dos Reis LG Cellular Biology Program, Brazilian National Cancer Institute (INCA), 37André Cavalcanti Street, 5th Floor, Rio de Janeiro, RJ, Brazil, - - 2014
Radiotherapy remains a major approach to adjuvant therapy for patients with advanced colorectal cancer and the fractionation schedules frequently allow for the repopulation of surviving tumors cells, neoplastic progression, and subsequent metastasis. The aim of the present study was to analyze the transgenerational effects induced by radiation and evaluate whether ...
Chaabane Chiraz C Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, - - 2014
It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant number of ...
Mello Paola de Andrade PD Laboratory of Biochemical and Cytological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, - - 2014
In cervical cancer, HPV infection and disruption of mechanisms involving cell growth, differentiation and apoptosis are strictly linked with tumor progression and invasion. Tumor microenvironment is ATP and adenosine rich, suggesting a role for purinergic signaling in cancer cell growth and death. Here we investigated the impact of extracellular ATP ...
Mohan Shalini S a Plant Biotechnology Division, School of Bio Sciences and Technology, VIT University , Vellore 632 014 , Tamil Nadu , - - 2014
Although some polyphenols are known to possess anticancer activity against different cancer cell lines through induction of apoptosis, the mode of antiproliferative effect of ethyl gallate against human oral squamous carcinoma cell line KB was not studied until now. Therefore, the antiproliferative effect of ethyl gallate was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...
Podkowa Monika M Hospital for Sick Children Research Institute, Cell Biology - - 2014
Comment on: Lubanska D and Porter LA. The atypical cell cycle regulator Spy1 suppresses differentiation of the neuroblastoma stem cell population. Oncoscience. 2014; 1: 336-348.
Casarin Elisabetta E Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, - - 2014
A different behavior of the two dibenzocyclooctadiene lignans (+)-deoxyschisandrin (1) and (-)-gomisin N (2), from Schisandra chinensis fruits, was observed against two human tumour cell lines, (2008 and LoVo). These lignans inhibited cell growth in a dose-dependent manner on both cell lines, but inducing different types of cell death. In ...
Clarke Rachel R Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Northern Ireland, United Kingdom. Electronic address: - - 2014
Aflatoxin B1 (AFB1), ochratoxin A (OTA) and fumonisin B1 (FB1) are contaminants which have been shown to regularly co-occur in a range of foods. However, only a small number of studies have evaluated the interactive effect of binary and tertiary mycotoxins. The present study evaluated the effects of low levels ...
Pan Jie-Hong JH Departments of Medicine, Washington University, Saint Louis, MO, 63110, - - 2014
The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63(+) basal epithelial progenitor cell generates a ciliated or secretory cell ...
Penthala Narsimha R NR Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, - - 2014
(E)-13-(Aryl/heteroaryl)parthenolides (5a-i and 6a-i) were synthesized and evaluated for their ability to modify cell cycle progression during progesterone-stimulated Xenopus oocyte maturation and screened for their anticancer activity against a panel of 60 human cancer cell lines. (E)-13-(4-aminophenyl) parthenolide (5b) caused a significant inhibition of progesterone-stimulated oocyte maturation, and was determined ...
Jia Ling-Fei LF Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China; Laboratory of Molecular Biology, Peking University School and Hospital of Stomatology, Beijing 100081, - - 2014
miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. The expression of miR-29b was analyzed in TSCC tissues and cells. Functional studies were performed in TSCC cells. ...
Yu Qilin Q Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin, PR - - 2014
Candida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases. Iron acquisition is an important factor for pathogen-host interaction, and also a significant element for the pathogenicity of this organism. Ferric reductases, which convert ferric iron into ferrous iron, are important components of the ...
Canović Elizabeth P EP Department of Biomedical Engineering, Boston University, Boston MA, - - 2014
Local intracellular variations of cell mechanical properties, which are essential for vital cellular functions, have not been well characterized and are poorly understood. Here, we used results from our previous biomechanical imaging study to obtain relationships between intracellular shear modulus and prestress. We found that the subcellular shear modulus vs. ...
Sancho Rocio R Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44, Lincoln's Inn Fields, London WC2A 3LY, - - 2014
The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition component Fbw7 ...
Baker Richard M RM Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, - - 2014
Understanding single and collective cell motility in model environments is foundational to many current research efforts in biology and bioengineering. To elucidate subtle differences in cell behaviour despite cell-to-cell variability, we introduce an algorithm for tracking large numbers of cells for long time periods and present a set of physics-based ...
Abouchar Laurent L Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, - - 2014
Developmental processes in multicellular organisms occur in fluctuating environments and are prone to noise, yet they produce complex patterns with astonishing reproducibility. We measure the left-right and inter-individual precision of bilaterally symmetric fly wings across the natural range of genetic and environmental conditions and find that wing vein patterns are ...
Chen Yan Y Department of Neurology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, - - 2014
Glucose is a necessary source of energy for sustaining cell activities and homeostasis in the brain. Enhanced glucose uptake protects cells during energy depletion including brain ischemia. Astrocytes enhance their glucose uptake during ischemia to supply substrates to neurons and thus support neuronal survival. Radiolabeled substrates are commonly used for ...
Nakamachi Tomoya T Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, - - 2014
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide considered to be a potent regulator of astrocytes. It has been reported that PACAP also affects astrocytoma cell properties, but the proliferative effects of this peptide in previous reports were inconsistent. The purpose of this study was to search for correlations ...
Fichter Christiane D CD Department of Pathology, University Medical Center, Breisacherstrasse 115A, 79106, Freiburg, - - 2014
ErbB family receptor tyrosine kinases (ErbBs) play a role in cell adhesion and migration and are frequently overexpressed in esophageal squamous cell carcinomas (ESCCs) or esophageal adenocarcinomas (EACs). Targeting ErbBs by tyrosine kinase inhibitors (TKIs) may therefore limit esophageal cancer cell migration. Here, we studied the impact of TKIs on ...
Gagliano Teresa T Section of Endocrinology, Department of Medical Sciences, University of Ferrara, Via A. Moro, 8, 44124, Ferrara, - - 2014
Mitotane is currently employed as adjuvant therapy as well as in the medical treatment of adrenocortical carcinoma (ACC), alone or in combination with chemotherapeutic agents. It was previously demonstrated that mitotane potentiates chemotherapeutic drugs cytotoxicity in cancer cells displaying chemoresistance due to P-glycoprotein (P-gp), an efflux pump involved in cancer ...
Kim Si Hyoung SH Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Republic of - - 2014
The effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG), an hsp90 inhibitor, alone or in combination with paclitaxel on survival of anaplastic thyroid carcinoma (ATC) was evaluated. In 8505C and CAL62 cells, after treatment of 17-AAG, cell viability decreased, and the percentage of dead cells increased. 17-AAG did not cause cleavage of caspase-3 protein, ...
Kobayashi Keisuke K Department of Pharmacy, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, - - 2014
Marine-derived Streptomyces sp. OPMA00072 was found to produce inhibitors of the synthesis of neutral lipids in a cell-based assay using Chinese hamster ovary (CHO) cells. A new 16-membered macrolide named bafilomycin L (BFL) (1) was isolated along with the known structurally related bafilomycin C1 (BFC1) (3) from the culture broth ...
Ostrovskaya Rita U - - 2014
BackgroundNoopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent ionic disbalance, excitotoxicity, free radicals and pro-inflammatory cytokines accumulation, ...
Cepko Connie C Departments of Genetics and Ophthalmology, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, - - 2014
Lineage studies conducted in the retina more than 25 years ago demonstrated the multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by individual RPCs, even from a single time point in development, were found to be highly variable. This raised the question of whether this ...
Burnette M M Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA. - - 2014
Drosophila cell culture is used as a model system with multiple applications including the identification of new therapeutic targets in screens, the study of conserved signal transduction pathway mechanisms, and as an expression system for recombinant proteins. However, in vitro methods for Drosophila cell and organ cultures are relatively undeveloped. ...
Chang Chia-Wen CW Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan. - - 2014
This paper reports a polydimethylsiloxane-polycarbonate (PDMS-PC) hybrid microfluidic device capable of performing cell culture under combinations of chemical and oxygen gradients. The microfluidic device is constructed of two PDMS layers with microfluidic channel patterns separated by a thin PDMS membrane. The top layer contains an embedded PC film and a ...
Lv Siliu S Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, P. R. China. pangsp@qibebt.ac.cn - - 2014
Formamidinium (FA) lead triiodide perovskite with chlorine addition (NH2CH[double bond, length as m-dash]NH2PbI(3-x)Clx) is employed as a light harvester in mesoscopic solar cells for the first time. It is demonstrated that a phase-pure FAPbI(3-x)Clx perovskite layer can be synthesized using a one-step solution-process at 140 °C, and the resultant solar ...
Song Tianran T Nanjing Drum Tower Hospital, Department of Obstetrics and Gynecology, Nanjing, China ; - - 2014
A variety of diseases may lead to hysterectomies or uterine injuries, which may form a scar and lead to infertility. Due to the limitation of native materials, there are few effective methods to treat such damages. Tissue engineering combines cell and molecular biology with materials and mechanical engineering to replace ...
Mazzawi T T 1] Section for Gastroenterology, Department of Medicine, Stord Hospital, Stord, Norway [2] Section for Gastroenterology, Institute of Medicine, Bergen University, Bergen, - - 2014
Background/objectives:The gastric endocrine cells in patients with irritable bowel syndrome (IBS) tend to normalize following dietary guidance. The aim of the present study was to identify the gastric endocrine cell types that are changed following such dietary guidance.Subjects/methods:Fourteen IBS patients and 14 healthy subjects were included in the study. Patients ...
Akopian Abram A http://orcid.org/0000-0002-2200-215X Department of Biological and Vision Sciences, State University of New York College of Optometry, New York, New York 10036, Department of Physiology & Neuroscience, New York University School of Medicine, New York, New York - - 2014
Secondary cell death via gap junctions (GJs) plays a role in the propagation of neuronal loss under a number of degenerative disorders. Here, we examined the role of GJs in neuronal death in the retina, which has arguably the most diverse expression of GJs in the CNS. Initially, we induced ...
Kotton Darrell N DN 1] Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, Massachusetts, USA. [2] Pulmonary Center, Boston University, Boston, Massachusetts, USA. [3] Department of Medicine, Boston University, Boston, Massachusetts, - - 2014
Recent studies have shown that the respiratory system has an extensive ability to respond to injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably quiescent, but after insult or injury progenitor populations can be activated or remaining cells can re-enter the cell cycle. Techniques including cell-lineage ...
Yamamoto Hideaki H Waseda Institute for Advanced Study, Waseda University, 1-6-1 Nishi-waseda, Shinjuku-ku, Tokyo 169-8050, Japan. Nanotechnology Research Center, Waseda University, 513 Waseda Tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, - - 2014
We demonstrate a novel application of TiO2 photocatalysis for modifying the cell affinity of a scaffold surface in a cell-culture environment. An as-deposited octadecyltrichlorosilane self-assembled monolayer (OTS SAM) on TiO2 was found to be hydrophobic and stably adsorbed serum albumins that blocked subsequent adsorption of other proteins and cells. Upon ...
Wang Zhanhui Z Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, - - 2014
The molecular cochaperone CDC37 regulates the activities of multiple protein kinases, and is an attractive broad-spectrum target in many types of cancers in which it is over-expressed. This study investigates the anti-tumor effects of inhibiting CDC37 in human hepatocellular carcinoma (HCC). A total of 91 patients were enrolled for CDC37 ...
Izumi Hideki H Division of Cancer Therapeutics, Research Institute for Clinical Oncology, Saitama Cancer Center - - 2014
Asymmetric cell division (ACD) is a physiological process during development and tissue homeostasis. ACD produces two unequal daughter cells; one has stem/progenitor cell activity and the other has potential for differentiation. Recent studies showed that misregulation of the balance between self-renewal and differentiation by ACD may lead to tumorigenesis in ...
Kelwick Richard R School of Biological Sciences, Biomedical Research Centre, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, - - 2014
The ADAMTS proteinases are a family of secreted, matrix-associated enzymes that have diverse roles in the regulation of tissue organization and vascular homeostasis. Several of the 19 human family members have been identified as having either tumour promoting or suppressing roles. We previously demonstrated that decreased ADAMTS15 expression correlated with ...
Tsui Ho-Ching T HC Department of Biology, Indiana University Bloomington, Bloomington, IN - - 2014
The relative localization patterns of class B penicillin-binding proteins Pbp2x and Pbp2b were used as positional indicators of septal and peripheral (side-wall-like) peptidoglycan (PG) synthesis, respectively, in the midcell regions of Streptococcus pneumoniae cells at different stages of division. We confirm that Pbp2x and Pbp2b are essential in the strain ...
Zhang Kun K College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, P. R. - - 2014
In this study, we explored the mechanism of the killing effects of a moderate-intensity static magnetic field (SMF) and cisplatin (DDP) on K562 cells. We analyzed the metabolic activity of cells, the extracellular DDP content, and P-glycoprotein (P-gp) expression after K562 cells were exposed continuously to a uniform 8.8 mT SMF ...
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