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Wang Ye Y School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, - - 2014
Here, we report a study on the biocompatibility, cell uptake and in vitro delivery of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by new nano-carriers called anodic alumina nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization process, which enables precise control of the nanotube geometry, ...
Zhang Biyuan B Internal Medicine-Oncology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, - - 2014
Background/Aims: Several studies have shown secreted clusterin (sCLU) silencing directed against sCLU mRNA in sCLU-rich lung cancer cell lines sensitized cells to chemotherapy. However, the molecular mechanisms underlying the effect of sCLU silencing on lung cancer cell chemosensitivity is not known. In the present study, we aimed to determine that ...
Sharma Shivani S Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA. - - 2014
Changes in cell stiffness (Young's modulus, E), as measured via Atomic Force Microscopy (AFM), is a newly recognized characteristic of cancer cells and may play a role in platinum drug resistance of ovarian cancers. We previously showed that, compared to their syngeneic cisplatin-sensitive counterpart, cisplatin-resistant ovarian cancer cells are stiffer, ...
Grogan Patrick T PT Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, - - 2014
Temozolomide (TMZ) has remained the chemotherapy of choice in patients with glioblastoma multiforme (GBM) primarily due to the lack of more effective drugs. Tumors, however, quickly develop resistance to this line of treatment creating a critical need for alternative approaches and strategies to resensitize the cells. Withaferin A (WA), a ...
Checa Sara S Julius Wolff Institute, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinkum, Institutsgebäude Süd/Südstraße 2, Augustenburger Platz 1, 13353 , Berlin, Germany, - - 2014
Physical cues play a fundamental role in a wide range of biological processes, such as embryogenesis, wound healing, tumour invasion and connective tissue morphogenesis. Although it is well known that during these processes, cells continuously interact with the local extracellular matrix (ECM) through cell traction forces, the role of these ...
Yamate Jyoji J Laboratories of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan. - - 2014
The original tumor, 4 cm in diameter, was found in the left testis of a 2-month old SD rat. The tumor consisted of well-differentiated, mature tissues such as bone, cartilage, adipose tissue, smooth and skeletal muscles, skin, hair, glands (salivary, sebaceous, apocrine and pancreatic exocrine glands) and trachea, as well ...
Zhong Aimei A Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
True macromastia is a rare but disabling condition characterized by massive breast growth. The aetiology and pathogenic mechanisms for this disorder remain largely unexplored because of the lack of in vivo or in vitro models. Previous studies suggested that regulation of epithelial cell growth and development by oestrogen was dependent ...
Lu Yangqing Y Guangxi University, State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Animal Reproduction Institute, 100 Daxue Road, Nanning, Guangxi, China, 530004, 86-13768580206, University of Georgia, Department of Animal and Dairy Science, Athens, Georgia, United States, University of Georgia, Regenerative Bioscience Center, Athens, Georgia, United States ; - - 2014
Germ cells are critically important as the vehicle that passes genetic information from one generation to the next. Correct development of these cells is essential and perturbation in their development often leads to reproductive failure and disease. Despite the importance of germ cells, little is known about the mechanisms underlying ...
Kim Mijung M Ophthalmology, Columbia University, 160 Fort Washington Ave. Rm#715, New York, NY, 10032, United - - 2014
Purpose: The efficacy of therapeutic cross-linking of the cornea using riboflavin photochemistry (commonly abbreviated as CXL) has caused its use to become widespread. Because there are known chemical agents to cross-link collagenous tissues, it may be possible to cross-link tissue pharmacologically. The present study was undertaken in order to compare ...
Lu Xiaowen X Cellular Biology and Anatomy, Georgia Regents University, 1459 Laney Walker Blvd., CB1101, Augusta, GA, 30912, United - - 2014
PURPOSE. Gap junctions are present in all corneal cell types and have been shown to play a critical role in cell phenotype determination. Vitamin D has been shown to influence cell differentiation, and recent work demonstrates the presence of vitamin D in the ocular anterior segment. This study measured and ...
da Costa Milene R MR Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; National Institute of Science and Technology for Structural Biology and Bioimaging, Rio de Janeiro, - - 2014
Acute kidney injury (AKI) is one of the more frequent and lethal pathological conditions seen in intensive care units. Currently-available treatments are not totally effective but stem cell-based therapies are emerging as promising alternatives, especially the use of mesenchymal stromal cells (MSC), although the signaling pathways involved in their beneficial ...
Engelsdorf Timo T Department of Biology, Høgskoleringen 5, Realfagbygget, Norwegian University of Science and Technology, 7491 Trondheim, - - 2014
BackgroundPlant cell walls form the interface between the cells and their environment. They perform different functions, such as protecting cells from biotic and abiotic stress and providing structural support during development. Maintenance of the functional integrity of cell walls during these different processes is a prerequisite that enables the walls ...
Zheng Yun-Ling YL Cancer Prevention and Control; Lombardi Comprehensive Cancer Center; Georgetown University Medical Center; Washington, DC - - 2014
Telomere lengths are tightly regulated within a narrow range in normal human cells. Previous studies have extensively focused on how short telomeres are extended and have demonstrated that telomerase plays a central role in elongating short telomeres. However, much about the molecular mechanisms of regulating excessively long telomeres is unknown. ...
Kong Weiqian W Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Jiangsu 215123, China. yangl@suda.edu.cn - - 2014
The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH2 ...
Santos Thiago M A TM Department of Biochemistry, University of Wisconsin-Madison, 440 Henry Mall, Madison, WI 53706, - - 2014
Subcellular biomolecular localization is critical for the metabolic and structural properties of the cell. The functional implications of the spatiotemporal distribution of protein complexes during the bacterial cell cycle have long been acknowledged; however, the molecular mechanisms for generating and maintaining their dynamic localization in bacteria are not completely understood. ...
Liu Yisheng Y 1 Department of Medicine, Henan Provincial People's Hospital , Zhengzhou, Henan Province, China - - 2014
Triptolide (TPL) is a major active component isolated from the natural herb Tripteryglum wilfordii Hook. F. It has proved to possess a variety of pharmacological effects including anti-inflammatory and antitumor activities. The aim of the present study is to explore the efficiency of combination therapy with TPL and oxaliplatin (OXA) ...
Condello Maria M Department of Technology and Health, Italian National Institute of Health , Rome, - - 2014
In previous studies it has been demonstrated that the plant alkaloid voacamine (1), used at noncytotoxic concentrations, enhanced the cytotoxicity of doxorubicin and exerted a chemosensitizing effect on cultured multidrug-resistant (MDR) U-2 OS-DX osteosarcoma cells. The in vitro investigations reported herein gave the following results: (i) the chemosensitizing effect of ...
Miyoshi Hiromi H RIKEN Center for Advanced Photonics, Ultrahigh Precision Optics Technology Team, Wako, Saitama, Japan ; - - 2014
The physiological role of the actin cytoskeleton is well known: it provides mechanical support and endogenous force generation for formation of a cell shape and for migration. Furthermore, a growing number of studies have demonstrated another significant role of the actin cytoskeleton: it offers dynamic epigenetic memory for guiding cell ...
Wang Tuo - - 2014
The polysaccharide structure and dynamics in the primary cell wall of the model grass, Brachypodium distachyon, are investigated for the first time using solid-state NMR. While both monocotyledonous (monocot, i.e. grass) and dicotyledonous (dicot) cell walls contain cellulose as the main structural scaffold, the former contains xylan with arabinose and ...
Geng Shuo S Department of Biological Sciences, Virginia - - 2014
Coleusin factor (CF) is a diterpenoid compound isolated from the root of a tropical plant, coleus forskohlii. Although CF has been reported to suppress proliferation and to induce apoptosis of several types of cancer cells, the effects of CF towards osteosarcoma and the underlying mechanism are still not fully understood. ...
Guo Yang Eric YE Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536, - - 2014
In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding (nc) RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in the T cell receptor (TCR) signaling pathway, including GRB2. Accordingly, transfection of ...
Park Jin Wan JW Department of Obstetrics and Gynecology, College of Medicine, College of Dentistry, Dankook University, Cheonan 330-714, South - - 2014
The umbilical cord blood (UCB) cells have been reported to secret therapeutic signals, including a series of neurotrophic factors. This suggests the cell source provides suitable therapeutic environments for nerve regeneration that ultimately finds a possible cell therapy for nerves. In this study, we test a collagen hydrogel provides human ...
Dos-Anjos Vilaboa Severiano S Stem Center, Palma de Mallorca, Spain. Electronic address: - - 2014
The adipose stromal vascular fraction (SVF) is a heterogeneous population of mononuclear cells that includes approximately 1-10% mesenchymal stromal cells. These SVF cells can be freshly obtained from human lipo-aspirates and represent and ideal candidate for regenerative medicine applications. In the present study, we analyzed the SVF yield as a ...
Ingvarsson Pall Thor PT Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, - - 2014
One of the main reasons for the unmet medical need for mucosal vaccines is the lack of safe and efficacious mucosal adjuvants. The cationic liposome-based adjuvant system composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) is a versatile adjuvant that has shown potential for mucosal vaccination via the airways. ...
Diniz Ivana Márcia Alves IM Restorative Dentistry Departament, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, CEP 31270-901, Belo Horizonte, - - 2014
The antibacterial photodynamic therapy (aPDT) has been used in dentistry against oral microorganisms because of its excellent biocide effect. However, for carious lesions applications, there is little evidence that this therapy is safe for the pulp tissue. This study evaluates the effects of an aPDT protocol on human pulp cells ...
Ingeson-Carlsson Camilla C Sahlgrenska Cancer Center (SCC), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Göteborg, - - 2014
Normal thyrocytes grown as reconstituted follicles in collagen gel were evaluated for drug effects of small molecule kinase inhibitors on growth factor-induced cell migration in a 3D context. MEK inhibition by U0126 only partially antagonized EGF/serum-induced cell migration from the basal follicular surface into the matrix. Combined treatment with U0126 ...
Xu Jinshu J Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, - - 2014
Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies ...
Cui Shu-Xiang SX Evaluation Center for Food and Drug, Capital Medical University, Beijing, - - 2014
13F-1 is a 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO2) COOCH3 tripeptide. 13F-1 might possess the activity against cancer growth by targeting Aminopeptidase N (APN/CD13). Our goal in this study was to evaluate the inhibitory effect of 13F-1 on the growth of human colonic carcinoma by both in vitro and in ...
Taniuchi Keisuke K Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783-8505, - - 2014
We report a novel function of RUVBL1 molecule in pancreatic cancer cells. Previous reports describe that RUVBL1 belongs to the family of AAA+ ATPases that associate with chromatin-remodelling complexes and have important roles in transcriptional regulation, the DNA damage response, telomerase activity and cellular transformation. We show that knockdown of ...
Maltese William A WA Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio. Electronic address: - - 2014
Apoptosis is the most widely recognized form of physiological programmed cell death. During the past three decades, various nonapoptotic forms of cell death have gained increasing attention, largely because of their potential importance in pathological processes, toxicology, and cancer therapy. A recent addition to the panoply of cell death phenotypes ...
Bohnenpoll Tobias T Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, - - 2014
Otic fibrocytes tether the cochlear duct to the surrounding otic capsule but are also critically involved in maintenance of ion homeostasis in the cochlea, thus, perception of sound. The molecular pathways that regulate the development of this heterogenous group of cells from mesenchymal precursors are poorly understood. Here, we identified ...
Yan Shihan S State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, PR - - 2014
Plant roots mainly consist of division, elongation and maturation regions. Histone modifications of chromatin play a vital role in plant cell growth and differentiation. However, there has been no systematic attempt to investigate the distribution patterns of histone modifications in the different plant root zones. In this study, histone H3 ...
Oum Boo Sup BS Department of Ophthalmology, School of Medicine, Pusan National University and Medical Research Institute, Pusan National University Hospital, Pusan, South - - 2014
Aims: To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. Methods: We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxacin 0.5% and gatifloxacin 0.3% on cultured human corneal epithelial cells. ...
Ikeda Ryo R Pain Research Center, Department of Anesthesiology, The University of Cincinnati College of Medicine, PO Box 670531, 231 Albert Sabin Way, Cincinnati, OH 45267-0531, USA; Department of Orthopaedic Surgery, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, - - 2014
Sensory systems for detecting tactile stimuli have evolved from touch-sensing nerves in invertebrates to complicated tactile end organs in mammals. Merkel discs are tactile end organs consisting of Merkel cells and Aβ-afferent nerve endings and are localized in fingertips, whisker hair follicles, and other touch-sensitive spots. Merkel discs transduce touch ...
Chen Esther Z EZ Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, - - 2014
Deranged cap-mediated translation is implicated in the genesis, maintenance and progression of many human cancers including mesothelioma. In this study, disrupting the eIF4F complex by antagonizing the eIF4E-mRNA-cap interaction is assessed as a therapy for mesothelioma. Mesothelioma cells were treated with 4Ei-1, a membrane permeable prodrug that when converted to ...
Kumarathasan Prem P Environmental Health Science and Research Bureau, Health Canada , Ottawa, Ontario , Canada - - 2014
Abstract While production of engineered carbon nanotubes (CNTs) has escalated in recent years, knowledge of risk associated with exposure to these materials remains unclear. We report on the cytotoxicity of four CNT variants in human lung epithelial cells (A549) and murine macrophages (J774). Morphology, metal content, aggregation/agglomeration state, pore volume, ...
Kitagawa Norio N Department of Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0193, - - 2014
Epidermal keratinocytes proliferate in the basal layer, differentiate, migrate through the spinous layer, granular layer and cornified layer, and finally are peeled off from the surface of skin with layer-specific expression of differentiation markers, including cytokeratins and cell-cell junction proteins such as desmogleins. Basal cells express CK5, CK14 and Ki67. ...
Annangi Balasubramanyam B Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona , Bellaterra , Spain - - 2014
Abstract A weak aspect of the in vitro studies devoted to get information on the toxic, genotoxic and carcinogenic properties of nanomaterials is that they are usually conducted under acute-exposure and high-dose conditions. This makes difficult to extrapolate the results to human beings. To overcome this point, we have evaluated ...
Ye Shuai S Department of Orthopedic Surgery, Chonbuk National University Medical School and Hospital, Jeonju, Republic of - - 2014
p63 is a member of the p53 protein family and plays a crucial role in epithelial development. p63 is expressed in many types of tumors including esophageal cancer; however, its function in cancer is controversial and its role in esophageal cancer has not been clearly established. In the present study, ...
Rajawat Jyotika J Department of Biochemistry, The Maharaja Sayajirao University of Baroda, - - 2014
Apoptosis involves a cascade of caspase activation leading to the ordered dismantling of critical cell components. However, little is known about the dismantling process in non-apoptotic cell death where caspases are not involved. D. discoideum is a good model system to study caspase independent cell death where experimental accessibility of ...
Panteris Emmanuel E Department of Botany; School of Biology; Aristotle University; Thessaloniki; Macedonia, - - 2014
Cell elongation requires directional deposition of cellulose microfibrils regulated by transverse cortical microtubules. Microtubules respond differentially to suppression of cell elongation along the developmental zones of Arabidopsis thaliana root apex. Cortical microtubule orientation is particularly affected in the fast elongation zone but not in the meristematic or transition zones of ...
Xie Min - - 2014
Early detection and isolation of circulating tumor cells (CTCs) can provide helpful information for diagnosis, and functional readouts of CTCs can give deep insight into tumor biology. In this work, we presented a new strategy for simple isolation and release of CTCs using engineered nanobioprobes. The nanobioprobes were constructed by ...
Lubarski Irina I The Weizmann - - 2014
FXYD5 (dysadherin or RIC) is a transmembrane auxiliary subunit of the Na(+)/K(+) ATPase shown to increase its Vmax. FXYD5 has also been identified as a cancer associated protein whose expression in tumor derived cell lines impairs cytoskeletal organization and increases cell motility. Previously, we have demonstrated that the expression of ...
Patil Vibha V Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; University of New South Wales; Sydney, NSW - - 2014
In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is crucial to normal development and cell differentiation. However, methylation of cytosines in the contexts of CpA, CpT, and CpC (non-CpG methylation) has been reported for decades, yet remains poorly understood. In recent years, whole genome bisulphite sequencing (WGBS) ...
Zhang Jian J *Arkansas Children's Nutrition Center, Little Rock, Arkansas, - - 2014
It has been suggested that the beneficial effects of soy protein isolate (SPI) on bone quality are due to either stimulation of estrogenic signaling via isoflavones or through a novel and as yet uncharacterized nonestrogenic pathway. In our study, SPI-fed rat serum inhibited the osteoblastic cell senescence pathway. This effect ...
Ralston Katherine S KS Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, - - 2014
Entamoeba histolytica is the causative agent of amoebiasis, a potentially fatal diarrhoeal disease in the developing world. The parasite was named "histolytica" for its ability to destroy host tissues, which is probably driven by direct killing of human cells. The mechanism of human cell killing has been unclear, although the ...
Seco-Rovira Vicente - - 2014
In the Syrian hamster (Mesocricetus auratus), an animal that displays testicular regression due to short photoperiod, germ cells are removed by apoptosis during these process and the apoptotic remains are phagocytized by Sertoli cells. The aim of this work was to investigate morphologically whether the testicular regression process due to ...
Evans Elizabeth B - - 2014
Continual sperm production relies on germ cells undergoing spermatogenesis asynchronously. As a result, the testis always contains a mixed population of germ cells at different stages of their differentiation process. The heterogeneous nature of the testis makes profiling gene expression within Sertoli cells or specific populations of germ cells impossible ...
Witte Christian C University of Glasgow, Division of Biomedical Engineering, G12 8LT, - - 2014
An optoelectronic tweezing (OET) device, within an integrated microfluidic channel, is used to precisely select single cells for lysis among dense populations. Cells to be lysed are exposed to higher electrical fields than their neighbours by illuminating a photoconductive film underneath them. Using beam spot sizes as low as 2.5 ...
Dong Shuping S Macromolecules and Interfaces Institute, ‡School of Biomedical Engineering and Sciences, §Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, and ∥Department of Sustainable Biomaterials, Virginia Tech , Blacksburg, Virginia 24061, United - - 2014
Elongated nanoparticles have recently been shown to have distinct advantages over spherical ones in targeted drug delivery applications. In addition to their oblong geometry, their lack of cytotoxicity and numerous surface hydroxyl groups make cellulose nanocrystals (CNCs) promising drug delivery vectors. Herein we report the synthesis of folic acid-conjugated CNCs ...
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