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Results 201 - 250 of 30654
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Tellez Noelia N N Tellez, Diabetes, Nutrition and Endocrine Diseases, CIBER of Diabetes and metabolic diseases, CIBERDEM, Barcelona, Spain - - 2014
Induction of β-cell mass regeneration is a potentially curative treatment of diabetes. We have recently found that long-term gastrin treatment results in improved metabolic control and β-cell mass expansion in 95% pancreatectomised (Px) rats. In the present study, we investigated the underlying mechanisms of gastrin-induced β-cell mass expansion after pancreatectomy. ...
Messa Mirko M Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, United - - 2014
Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, ...
Máté Gábor G Department of General and Environmental Microbiology, Faculty of Sciences, University of Pécs, Pécs, - - 2014
In this study, the citrinin (CTN)-induced accumulation of reactive oxygen species (ROS) and the regulation of the activities of antioxidant enzymes were investigated in acute toxicity tests in Schizosaccharomyces pombe. 30% of the CTN was accumulated by the cells in 1000 μM CTN solution. In comparison with the control, exposure ...
Yin Ling L Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, China. - - 2014
Two-dimensional graphene has tremendous potential to be used as a transparent conducting electrode (TCE), owing to its high transparency and conductivity. To date graphene films have been applied to several kinds of solar cells except the Cu(In, Ga)Se2 (CIGS) solar cell. In this work, we present a novel TCE structure ...
Turner David A - - 2014
BackgroundThe formation of the Primitive Streak is the first visible sign of gastrulation, the process by which the three germ layers are formed from a single epithelium during early development. Embryonic Stem Cells (ESCs) provide a good system to understand the molecular and cellular events associated with these processes. Previous ...
Zhu Daqiang D Department of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of - - 2014
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mainly induces apoptosis through the extrinsic death receptor-induced pathway by ligation with death receptor 4 (DR4) and death receptor 5 (DR5). On the basis of the antitumor activity to cancer cells and no cytotoxity to normal cells of TRAIL and the target of the ...
Zhang Chen - - 2014
PPM1D (protein phosphatase, Mg2+/Mn2+ dependent, 1D) has been reported to be involved in multiple human tumors. This study was designed to investigate the functional role of PPM1D in lung cancer cells. Expression levels of PPM1D were analyzed in A549 and H1299 cells by real-time PCR and Western blotting. Lentivirus-mediated short ...
Unterlauft Jan Darius JD Department of Ophthalmology and Eye Hospital, University of Leipzig, - - 2014
The death of retinal ganglion cells (RGC) leads to visual impairment and blindness in ocular neurodegenerative diseases, primarily in glaucoma and diabetic retinopathy; hence, mechanisms that contribute to protecting RGC from ischemia/hypoxia are of great interest. We here address the role of retinal glial (Müller) cells and of pigment-epithelium-derived factor ...
Lee Do-Hyun DH Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of - - 2014
By virtue of the biocompatibility and physical properties of hydrogel, picoliter-sized hydrogel microcapsules have been considered as a biometric signature that contains several features that are similar to that of the encapsulated single cells, including phenotype, viability, and intracellular content. To maximize the experimental potential of encapsulating cells in hydrogel ...
Nistal Manuel M a Hospital La Paz, Universidad Autónoma de Madrid, - - 2014
Abstract 1.INTRODUCTION 2.DEVELOPMENT OF THE BIPOTENTIAL GONAD 2 a. Formation of gonadal ridge 2 b. Primordial germ cells. Origin, migration and formation of gonadal blastema 2 c. Male-female determination 3.TESTIS DIFFERENTIATION. DEVELOPMENT OF SEMINIFEROUS CORDS 3 a. Early organization of gonadal blastema 3 b. Migration of mesonephric elements 3 c. ...
Feihl Sebastian S Friedrich-Alexander-University Erlangen-Nuremberg, Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials, Egerlandstr. 3, 91058 Erlangen, Germany. ruben.costa@fau.de - - 2014
In the current work, we have explored a novel synthetic route towards metalated porphycenes and their use in p-type NiO-based dye-sensitized solar cells. Particular emphasis is placed on the influence that the relative positioning of the anchoring group exerts on the DSSC performance.
Goehring Nathan W NW Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: - - 2014
The par-titioning-defective or PAR proteins comprise the core of an essential cell polarity network that underlies polarization in a wide variety of cell types and developmental contexts. The output of this network in nearly every case is the establishment of opposing and complementary membrane domains that define a cell's polarity ...
Di Kaijun K Department of Neurological Surgery, UC Irvine School of Medicine, Sprague Hall, Irvine, CA, 92697, - - 2014
Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the expression pattern of Hsp90α/β mRNA ...
Franke Jana J Institute of Pharmacology, Pharmacy and Toxicology, University of Leipzig, An den Tierkliniken 15, 04103 Leipzig, - - 2014
Altered airway cell proliferation plays an important role in the pathogenesis of human bronchial asthma and chronic obstructive pulmonary disease (COPD) as well as the equine recurrent airway obstruction (RAO) with consistent changes, i.e. narrowing the airway wall, explained by proliferation and differentiation of fibroblasts. In permanent cell lines, it ...
Li Na N Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, - - 2014
Cancer stem cells (CSCs) are a subset of cancer cells that play key roles in metastasis and cancer relapse. The elimination of CSCs is very important during cancer therapy. To develop drugs that target CSCs, the isolation and identification of putative CSCs are required. Some of the characteristics of CSCs ...
Bely Alexandra E AE Department of Biology, University of Maryland, College Park, MD 20742, USA - - 2014
The ability to regenerate extensive portions of the body is widespread among the phylum Annelida and this group includes some of the most highly regenerative animals known. Knowledge of the cellular and molecular basis of regeneration in this group is thus important for understanding how regenerative processes have evolved both ...
Marjanovic Ana Marija AM Radiation Dosimetry and Radiobiology Unit, Institute for Medical Research and Occupational Health , Zagreb , - - 2014
Abstract Aim of this study was to evaluate an influence of modulated radiofrequency field (RF) of 1800 MHz, strength of 30 V/m on oxidation-reduction processes within the cell. The assigned RF field was generated within Gigahertz Transversal Electromagnetic Mode cell equipped by signal generator, modulator, and amplifier. Cell line V79, was irradiated ...
Hagl Stephanie S Goethe-University, Frankfurt, - - 2014
Mitochondrial dysfunction plays an important role in brain aging and has emerged to be an early event in Alzheimer's disease (AD), contributing to neurodegeneration and the loss of physical abilities seen in patients suffering from this disease. We examined mitochondrial dysfunction in a cell culture model of AD (PC12APPsw cells) ...
Owonikoko Taofeek K TK Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, Georgia; Winship Cancer Institute of Emory University, Atlanta, - - 2014
Poly (ADP) ribose polymerase (PARP) plays a key role in DNA repair and is highly expressed in small cell lung cancer (SCLC). We investigated the therapeutic impact of PARP inhibition in SCLC. In vitro cytotoxicity of veliparib, cisplatin, carboplatin, and etoposide singly and combined was determined by MTS in 9 ...
Febles Nicole - - 2014
This article reports label-free, real-time, and single cell quantification of the invasion of spheroidal colon cancer cells through three-dimensional (3D) Matrigel using a resonant waveguide grating (RWG) imager. This imager employs a time-resolved swept wavelength interrogation scheme to monitor cell invasion and adhesion with a temporal resolution up to 3sec ...
Lin Zhaoyu Z Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Oral & Maxillofacial Surgery, Sun Yat-sen University, Guangzhou, - - 2014
Epithelial-to-mesenchymal transition (EMT) is implicated in embryonic development and various pathological events. TGFβ has been reported to induce EMT in tumor cells, which is a critical step in the process of metastasis leading to cancer spreading and treatment failure. However, the involvement of microRNA during the EMT process in tongue ...
Vorhagen Susanne S Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of - - 2014
Oriented cell division is a key regulator of tissue architecture and crucial for morphogenesis and homeostasis. Balanced regulation of proliferation and differentiation is an essential property of tissues not only to drive morphogenesis but also to maintain and restore homeostasis. In many tissues orientation of cell division is coupled to ...
Tian Dan - - 2014
BackgroundThe insulin-like growth factor (IGF) system impacts cell proliferation and is highly activated in ovarian cancer. While an attractive therapeutic target, the IGF system is complex with two receptors (IGF1R, IGF2R), two ligands (IGF1, IGF2), and at least six high affinity IGF-binding proteins (IGFBPs) that regulate the bioavailability of IGF ...
Setua Sonali S Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB3 0FF, UK. - - 2014
Glioblastoma multiforme (GBM) remains the most aggressive and challenging brain tumour to treat. We report the first successful chemo-radiotherapy on patient derived treatment resistant GBM cells using a cisplatin-tethered gold nanosphere. After intracellular uptake, the nanosphere effects DNA damage which initiates caspase-mediated apoptosis in those cells. In the presence of ...
Xia Lijie L Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, - - 2014
Antimicrobial peptides exist in the non-specific immune system of organism and participate in the innate host defense of each species. CecropinXJ, a cationic antimicrobial peptide, possesses potent anticancer activity and acts preferentially on cancer cells instead of normal cells, but the mechanism of cancer cell death induced by cecropinXJ remains ...
Zhang Hongyi H Department of Hepatobiliary Surgery, Air Force General Hospital, Beijing 100142, P.R. - - 2014
MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream SREBP-lipogenesis-cholesterogenesis metabolic pathway ...
Chen Yu-Chih YC Department of Electrical Engineering and Computer Engineering, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA. - - 2014
Cancer-stromal interaction is a critical process in tumorigenesis. Conventional dish-based co-culture assays simply mix two cell types in the same dish; thus, they are deficient in controlling cell locations and precisely tracking single cell behavior from heterogeneous cell populations. Microfluidic technology can provide a good spatial-temporal control of microenvironments, but ...
Ni Xi-Lu XL School of Life Science, Northwest University, Xi'an, 710069, China; State Key Laboratory of Seedling Bioengineering, Ningxia Forestry Institute, Yinchuan, 750004, - - 2014
Some species of Allium in Liliaceae have fistular leaves. The fistular lamina of A. fistulosum undergoes a process from solid to hollow during development. The aims were to reveal the process of fistular leaf formation was involved in programmed cell death (PCD), and to compare the cytological events in the ...
Wilson S S SS Department of Microbiology, University of Washington, Seattle, Washington, - - 2014
Organoids mirror in vivo tissue organization and are powerful tools to investigate the development and cell biology of the small intestine. However, their application for the study of host-pathogen interactions has been largely unexplored. We have established a model using microinjection of organoids to mimic enteric infection, allowing for direct ...
Zajączkowska Urszula U Department of Forest Botany, Warsaw University of Life Sciences (WULS), 159 Nowoursynowska Str, 02-776, Warsaw, Poland, - - 2014
Stump overgrowth may serve as a unique model for studying cellular reorganization and mechanisms responsible for cell polarity changes during the process of vascular tissue differentiation from initially unorganized parenchymatous cells. Cellular ordering and tissue reorganization during the overgrowth process of the transverse surfaces of Douglas fir stumps in forest ...
Chen Yi-Hsin YH Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, Taipei, 106, - - 2014
In this study, we compared the detachment ratio of HaCaT and Hs68 cells from pH-responsive chitosan surface by raising medium pH from 7.20 to 7.65 for 60 min. The detachment ratio of elongated Hs68 cells was over 75%, but that of round-shaped HaCaT cells was less than 50%, even extending the incubation time ...
Sharp Thad T The University of Iowa, United - - 2014
Pitx2, Wnt/β-catenin signaling and microRNAs (miRs) play a critical role in the regulation of dental stem cells during embryonic development. In this report, we have identified a novel Pitx2:β-catenin regulatory pathway involved in epithelial cell differentiation and conversion of mesenchyme cells to amelogenin expressing epithelial cells via miR-200a. Pitx2 and ...
Jang Won-Jun WJ College of Pharmacy, Keimyung University, Daegu, 704-701, South - - 2014
Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been introduced for the treatment of non-small cell lung cancer (NSCLC), the emergence of secondary T790M mutation in EGFR or amplification of the Met proto-oncogene restrain the clinical success of EGFR-TKIs. Since heat shock protein-90 (Hsp90) stabilizes various oncoproteins including EGFR ...
Knox Aaron J - - 2014
IntroductionMany Luminal breast cancers are heterogeneous, containing substantial numbers of estrogen (ER) and progesterone (PR) receptor-negative cells among the ER¿+¿PR¿+¿ones. One such subpopulation we call ¿Luminobasal¿ is ER-, PR- and cytokeratin 5 (CK5)-positive. It is not targeted for treatment.MethodsTo address the relationships between ER¿+¿PR¿+¿CK5- and ER-PR-CK5+ cells in Luminal cancers ...
Lachambre Simon S CPBS, UMR 5236 CNRS-Université de Montpellier, 1919 Route de Mende, 34293, - - 2014
Cells, especially those of the immune system, can form long and thin connections termed tunneling nanotubes (TNTs). These structures can reach >100 μm in length and, in T-cells, contain actin but no tubulin and are not open ended. T-cell TNTs were found to form following cell contact and to enable ...
Singh Nimisha N Division of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South - - 2014
Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis. These cancers are deficient in glucocorticoid receptor (GR) expression, and therefore, resistant to glucocorticoids. Overexpression of the GR both in vivo and in vitro leads to apoptotic cell death suggesting that loss of GR is favorable for ...
Lin Rong R Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, - - 2014
The aim of this study was to investigate the influence of gut microbiota on autophagy activation in intestinal epithelial cells (IECs). In addition, the IEC autophagy response to different types of bacteria was also evaluated. IEC-18 cells were treated with lipopolysaccharide (LPS) derived from enteropathogenic Escherichia coli (EPEC) O127:B8 and ...
Wang Han H Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, - - 2014
Microfluidic live cell arrays with integrated concentration gradient or mixture generators have been utilized in screening cellular responses to various biomolecular cues. Microfluidic network-based gradient generators that can create concentration gradients by repeatedly splitting and mixing different solutions using networks of serpentine channels are commonly used. However, in this method ...
Li Xiao-Ling XL College of Life Sciences and Technology, Jinan University, Guangzhou, China, - - 2014
Human islet amyloid polypeptide (hIAPP) aggregation is linked to loss of pancreatic beta cells in type 2 diabetes, in part due to oxidative stress. Currently, little is known about the effects of selenium-enriched Spirulina on beta cells with the presence of hIAPP. In this study, INS-1E rat insulinoma cells were ...
Shutova Maria S MS Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
Class II myosins generate contractile forces in cells by polymerizing into bipolar filaments and pulling on anchored actin filaments. Nonmuscle myosin II (NMII) plays central roles during cell adhesion, migration, cytokinesis, and tissue morphogenesis. NMII is present in virtually all mammalian cell types as tissue-specific combinations of NMIIA, NMIIB, and ...
Whipple C A CA Departments of Medicine, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, and Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, - - 2014
Background:Melanoma, the most lethal form of skin cancer, is responsible for over 80% of all skin cancer deaths and is highly metastatic, readily spreading to the lymph nodes or metastasising to other organs. The frequent genetic mutation found in metastatic melanoma, BRAF(V600E), results in constitutive activation of the mitogen-activated protein ...
Yamashita Takehiro T Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima, 890-8520, - - 2014
To determine the symmetry of the retinal thicknesses (RT) between the 32 pairs of superior and inferior sectors by posterior pole asymmetrical analysis (PPAA) of the spectral domain optical coherence tomographic (SD-OCT) images in healthy eyes. In addition, to determine their association with the position of the peak retinal nerve ...
Takahashi Akihisa A a  Advanced Scientific Research Leaders Development Unit, Gunma University, - - 2014
DNA double-strand breaks (DSBs) induced by ionizing radiation pose a major threat to cell survival. The cell can respond to the presence of DSBs through two major repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). Higher levels of cell death are induced by high-linear energy transfer (LET) radiation ...
Choi Jae Sue JS Department of Food and Life Science, College of Fisheries Science, Pukyong National University, Busan 608-737, Republic of - - 2014
Obesity is a complex, multifactorial, and chronic disease that increases the risk for type 2 diabetes, coronary heart disease and hypertension, and has become a major worldwide health problem. Developing novel anti-obesity drugs from natural products is a promising solution to the global health problem of obesity. While screening anti-obesity ...
Bi Hui-Chang HC Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China - - 2014
The cell metabolome comprises abundant information that may be predictive of cell functions in response to epigenetic or genetic changes at different stages of cell proliferation and metastasis. An unbiased UPLC-MS-based metabolomics study revealed a significantly altered metabolome for human pancreatic carcinoma PANC-1 cells with gain-of-function noncoding microRNA-1291 (miR-1291), which ...
Gopalan Vinod V Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, - - 2014
miR-498 is a non-coding RNA located intergenically in 19q13.41. Due to its predicted targeting of several genes involved in control of cellular growth, we examined the expression of miR-498 in colon cancer cell lines and a large cohort of patients with colorectal adenocarcinoma. Two colon cancer cancer cell lines (SW480 ...
Sahin Başak B Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2V2, - - 2014
Cutaneous T-cell lymphomas (CTCLs) arise from specific molecular aberrations that lead to uncontrolled cell proliferation. RNA interference (RNAi) with short interfering RNAs (siRNAs) is a feasible approach to interrupt aberrant signal processing in CTCL cells, but functional biomaterial carriers are needed to effectively deliver siRNAs intracellularly. Towards this goal, we ...
Chung Yuan-Chiang - - 2014
In the process of epithelial mesenchymal transition EMT, the disassembly of junctional adhesion complexes such as E-cadherin is a remarkable sign during changes in cell morphology and polarity. However, E-cadherin expression is dynamic, and is regulated by the cellular endocytic system; it is also involved in cell signaling mechanisms. In ...
Manning Alyssa J AJ Department of Biochemistry, Box 357350, The University of Washington, Seattle, WA - - 2014
Epithelia form the building blocks of many tissue and organ types. Epithelial cells often form a contiguous 2-dimensional sheet that is held together by strong adhesions. The mechanical properties conferred by these adhesions allow the cells to undergo dramatic three-dimensional morphogenetic movements while maintaining cell-cell contacts during embryogenesis and post-embryonic ...
Filla Mark S MS Department of Ophthalmology & Visual Sciences, Medical Science Center, 1300 University Ave., Madison, WI 53706. Electronic address: - - 2014
In this study, we examined the role(s) of syndecan-4 in regulating the formation of an actin geodesic dome structure called a cross-linked actin network (CLAN) in which syndecan-4 has previously been localized. CLANs have been described in several different cell types, but they have been most widely studied in human ...
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