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Aas-Hanssen Kristin K Centre for Immune Regulation, Department of Immunology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, 0424 Oslo, Norway; and kristin.aas-hanssen@medisin.uio.no bjarne.bogen@medisin.uio.no - - 2014
Systemic lupus erythematosus (SLE) is marked by a Th cell-dependent B cell hyperresponsiveness, with frequent germinal center reactions and hypergammaglobulinemia. The specificity of Th cells in lupus remains unclear, but B cell idiotypes (Ids) have been suggested. A hallmark is the presence of anti-dsDNA, mutated IgG autoantibodies with a preponderance ...
Tsai Robert Y L - - 2014
A quintessential trait of stem cells is embedded in their ability to self-renew without incurring DNA damage as a result of genome replication. One key self-renewal factor is the nucleolar GTP-binding protein nucleostemin (also known as guanine-nucleotide-binding protein-like 3, GNL3, in invertebrate species). Several studies have recently pointed to an ...
Chen Xiaojiao X Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing 100084, China. - - 2014
A multivalent recognition and alkaline phosphatase (ALP)-responsive electrogenerated chemiluminescence (ECL) biosensor for cancer cell detection and in situ evaluation of cell surface glycan expression was developed on a poly(amidoamine) (PAMAM) dendrimer-conjugated, chemically reduced graphene oxide (rGO) electrode interface. In this strategy, the multivalency and high affinity of the cell-targeted aptamers ...
Pietra Stefano S Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, SE-90187, Umeå, - - 2014
Patterned differentiation of distinct cell types is essential for the development of multicellular organisms. The root epidermis of Arabidopsis thaliana is composed of alternating files of root hair and non-hair cells and represents a model system for studying the control of cell fate acquisition. Epidermal cell fate is regulated by ...
Pampaloni Barbara B Barbara Pampaloni, Gaia Palmini, Carmelo Mavilia, Roberto Zonefrati, Annalisa Tanini, Maria Luisa Brandi, Department of Surgery and Translational Medicine, University of Florence, Florence 50139, - - 2014
To investigate the effects of quercetin and genistein on colon cancer cell proliferation and their estrogen receptor β (ERβ) expression. Colon cancer cells were stably transfected with a mammalian expression vector to overexpress ERβ (HCT8-β8-expressing cells) or a control vector (HCT8-pSV2neo-expressing cells). The proliferation of these cells was examined after ...
Hoffman Kathleen K American Dental Association Foundation, Biomaterials, Gaithersburg, Maryland, United States ; - - 2014
Electrospun polymer nanofibers have multiple applications in the tissue engineering field despite limited cell penetration within the scaffolds and slow synthesis rates. Airbrushing, a proposed alternative to traditional electrospinning, is a technique capable of synthesizing open structure nanofiber scaffolds at high rates. In this study, three biocompatible polymers; poly-D,L-lactic acid ...
Cardoso Rhanderson Miller Nascimento RM School of Medicine, Federal University of Goiás, Goiânia, - - 2014
Regulatory T (Treg) cells may play an important role in the pathogenesis of paracoccidioidomycosis (PCM), but data on the role of Treg cells in the context of oral PCM are still scarce. The objectives of this study were to investigate the density of FoxP3(+) T regulatory cells in oral PCM ...
Cologgi Dena L DL Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, - - 2014
Biofilms formed by dissimilatory metal reducers are of interest to develop permeable biobarriers for the immobilization of soluble contaminants such as uranium. Here we show that biofilms of the model uranium-reducing bacterium Geobacter sulfurreducens immobilized substantially more U(VI) than planktonic cells and for longer periods of time, reductively precipitating it ...
Jiang Maorong M Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, People's Republic of - - 2014
Chitosan-based tissue engineered nerve grafts are successfully used for bridging peripheral nerve gaps. The biodegradation products of chitosan are water-dissolvable chitooligosaccharides (COSs), which have been shown to support peripheral nerve regeneration. In this study, we aimed to examine in vitro interactions between COSs and Schwann cells (SCs), the principal glial ...
Díaz-Carballo David D 1 Institute of Molecular Oncology and Experimental Therapeutics, Marienhospital Herne, Ruhr University of Bochum Medical School , Herne, Germany - - 2014
Until recently, acquired resistance to cytostatics had mostly been attributed to biochemical mechanisms such as decreased intake and/or increased efflux of therapeutics, enhanced DNA repair, and altered activity or deregulation of target proteins. Although these mechanisms have been widely investigated, little is known about membrane barriers responsible for the chemical ...
Zorofchian Moghadamtousi Soheil - - 2014
Annona muricata leaves have been reported to have antiproliferative effects against various cancer cell lines. However, the detailed mechanism has yet to be defined. The current study was designed to evaluate the molecular mechanisms of A. muricata leaves ethyl acetate extract (AMEAE) against lung cancer A549 cells. The effect of ...
Ferris Robert L RL Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and Cancer Immunology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA - - 2014
T cell exhaustion is thought to be a natural mechanism for limiting immune pathology, although it may be desirable to circumvent this mechanism to help eliminate viral reservoirs or tumors. Although there are no definitive markers, a fingerprint for exhausted T cells has been described that includes the transmembrane proteins ...
Masetto Tathiana E TE Faculdade de Ciências Agrárias, Universidade Federal da Grande Dourados/UFGD, Dourados, MS, - - 2014
This work aimed to characterize the re-induction of desiccation tolerance (DT) in germinated seeds, using polyethylene glycol (PEG 8000). Cell changes were investigated through cytological assays (cell viability and transmission electronic microscopy) as well as DNA integrity during loss and re-establishment of DT. The loss of DT was characterized by ...
Kumar Kandikattu Hemanth KH Biochemistry and Nanosciences Discipline, Defence Food Research Laboratory, Siddarthanagar, Mysore, 570011, Karnataka, - - 2014
Identification, exploration and scientific validation of antioxidant rich herbal extracts to mitigate the radical induced cell damage provide new insights in the field of ayurvedic research/therapies. In the present study, we evaluated the anti-oxidant and anti-apoptotic potential of Celastrus paniculatus seed extract (CPSE) against tertiary butyl hydroperoxide (t-BHP) induced mice ...
Lima Ana Catarina AC 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, - - 2014
Platelet lysate (PL) was encapsulated in collagen (Coll) millimetric gel beads, on biomimetic superhydrophobic surfaces, under mild conditions, with the aim of obtaining easy-to-handle formulations able to provide sustained release of multiple growth factors for skin ulcers treatment. The gel particles were prepared with various concentrations of PL incorporating or ...
Zuryn Steven S Department of Development and Stem Cells, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104/INSERM U964, Université de Strasbourg, 67404 Illkirch CU Strasbourg, - - 2014
Natural interconversions between distinct somatic cell types have been reported in species as diverse as jellyfish and mice. The efficiency and reproducibility of some reprogramming events represent unexploited avenues in which to probe mechanisms that ensure robust cell conversion. We report that a conserved H3K27me3/me2 demethylase, JMJD-3.1, and the H3K4 ...
Yeo Siok-Koon SK Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800, Penang, - - 2014
This study aimed to evaluate the effects of electroporation on growth, bioconversion of isoflavones, and probiotic properties of parent organisms and subsequent passages of Bifidobacterium longum FTDC 8643. Electroporation with the strength of electric field at 7.5 kV cm(-1) for 3.5 ms was applied on B. longum FTDC 8643. The viability of B. ...
Sun Kai K Tianjin Medical University, Qi Xiangtai Road No. 22, Heping District, Tianjin, 300070, China, - - 2014
In this study, the silk fibroin blended constructs were produced, scaffold performances of different kinds of scaffold were analyzed, and the better type for tissue engineering was optimized. The silk fibroin/collagen (SF/C) and silk fibroin/chitosan (SF/CS) were made using a freeze-drying technique, porosity, water absorption expansion rate, mechanical properties and ...
Zhang Li-Guang LG Key Laboratory of Biorheological Science and Technology of the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR - - 2014
We have developed a polydimethylsiloxane (PDMS) pattern with arrays of microwells for the formation of multicellular aggregates by C17.2 neural stem cells. Upon interfacing with the patterns, the neural stem cells would firstly attach to the microwell sidewalls, forming cellular strips on day 1 after plating. For channel connected microwells, ...
Watanabe Yusaku Y Department of Digestive Surgery and Surgical Oncology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, - - 2014
Cancer stem cells (CSCs) have been studied for their self-renewal capacity and pluripotency, as well as their resistance to anticancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their population is quite low in tumor specimens. To overcome this problem, we established a ...
Morris Samantha A SA Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, - - 2014
Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but most protocols fail to faithfully recapitulate target cell properties. To address this, we developed CellNet, a network biology platform that determines whether engineered cells are equivalent to their target tissues, diagnoses aberrant gene regulatory networks, and prioritizes candidate transcriptional ...
Sharaby Yaara Y The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel; Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 5290002, - - 2014
Growth arrest-specific 2-like 3 (Gas2l3) is a newly discovered cell cycle protein and a cytoskeleton orchestrator that binds both actin filament and microtubule networks. Studies of cultured mammalian cells established Gas2l3 as a regulator of the cell division process, in particular cytokinesis and cell abscission. Thus far, the role of ...
Chanput Wasaporn W Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngamwongwan Rd., Lad Yao, Chatuchak, Bangkok 10900 Thailand. Electronic address: - - 2014
THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and nutrient and drug transport. This cell line has become a common model to estimate modulation of monocyte and macrophage activities. This review attempts to summarize and discuss recent publications ...
Jungebluth Philipp P Advanced Center for Translational Regenerative Medicine, Department for Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat, Stockholm, - - 2014
Tissue-engineered tracheal transplants have been successfully performed clinically. However, before becoming a routine clinical procedure, further preclinical studies are necessary to determine the underlying mechanisms of in situ tissue regeneration. Here we describe a protocol using a tissue engineering strategy and orthotopic transplantation of either natural decellularized donor tracheae or ...
Kwon Soon-Jae SJ Department of Food Science and Technology, Kyungpook National University, Daegu 702-701, Republic of - - 2014
Isoegomaketone (IK) is a major biologically active component of Perilla frutescens. In this study, we investigated the contribution of reactive oxygen species (ROS) to IK-induced apoptosis in human melanoma SK-MEL-2 cells. We found that IK inhibited the proliferation of SK-MEL-2 human melanoma cells in a dose-dependent manner. IK also induced ...
de Araújo Júnior Raimundo Fernandes RF Post Graduation Program Health Science, Department of Medicine, UFRN, Natal, RN, Cep: 59078-970, Brazil Post Graduation Program in Functional and Structural Biology, Department of Morphology, UFRN, Natal, RN, Cep: 59078-970, Brazil - - 2014
It has been well-characterized that the renin-angiotensin system (RAS) physiologically regulates systemic arterial pressure. However, RAS signaling has also been shown to increase cell proliferation during malignancy, and angiotensin receptor blockers (ARBs) are able to decrease pro-survival signaling by inhibiting anti-apoptotic molecules and suppressing caspase activity. In this study, the ...
Homem Catarina C F CC Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, - - 2014
Stem cells are highly abundant during early development but become a rare population in most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a specific time are not well understood. Here, we show that changes in energy metabolism induced by the steroid hormone ecdysone and the Mediator ...
Lallier Thomas E TE Department of Cell Biology and - - 2014
Objectives: The toxic effects of cigarette smoke often presents in smokers as increased incidences and severity of periodontal disease. These patients demonstrate symptomatic inflammation, increased pocket depth, and tooth loss likely due to the direct effects of cigarette smoke on periodontal ligament (PDL) fibroblasts. The goal of this in vitro ...
Wang Ning N Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, - - 2014
This study was to investigate the anticancer effects of baicalein (Bai) and its two sulfated derivatives, namely baicalein-7-O-sulfate (BoS) and baicalein-8-sodium sulfonate (BcS). BcS was shown to exhibit stronger growth inhibition against human breast cancer MCF-7 cells, compared with structurally related Bai and BoS, where IC50 values of BoS, Bai ...
Zhao Bin B Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, - - 2014
Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of ...
Liu Jianhua J Department of Respiratory Medicine, The First Affiliated Hospital of Hebei North University, 075000, Zhangjiakou, - - 2014
Photodynamic therapy (PDT) involves the administration and activation of photosensitizing reagents in cancer tissues to induce cytotoxicity. Here we examined the effects of 5-5- (4-N, N-diacetoxylphenyl)-10,15,20- tetraphenylporphyrin (DTPP) -mediated PDT on cell morphology, viability, cell cycle, and cytotoxicity in a murine lung adenocarcinoma cell line. LA795 murine lung adenocarcinoma cell ...
Swierzy Izabela J IJ Institute for Medical Microbiology, University Medical Center, Georg-August-University, Kreuzbergring 57, D-37075 Göttingen, - - 2014
Toxoplasma gondii is a widespread intracellular parasite of mammals and birds and an important opportunistic pathogen of humans. Following primary infection, fast replicating tachyzoites disseminate within the host and are subsequently either eliminated by the immune system or transform to latent bradyzoites which preferentially persist in brain and muscle tissues. ...
Liu Yang Y Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA, 02114, United - - 2014
Purpose:Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease, a prevalent disorder severely affecting patients' quality of life but has no cure. We have discovered that azithromycin, a topical antibiotic used off-label to treat MGD-associated posterior blepharitis, directly acts on the human meibomian gland epithelial cells (HMGECs) ...
Jeong Dayeong D School of Interdisciplinary Bioscience and Bioengineering, POSTECH, 77 Cheongam-Ro, Pohang, Gyeongbuk 790-784, Republic of - - 2014
Extracellular vesicles (Exosomes and microvesicles) have drawn wide attentions in both diagnostic and therapeutic applications, since they are considered to shuttle biological signals intercellularly. However, further research on exosomes is limited by their rarity and heterogeneity even after lengthy isolation processes. In particular, these limitations are challenging in therapeutic applications. ...
- - 2014
The year 2014 marks Cell's 40th anniversary, and we are looking back at how discoveries over the last four decades have molded our understanding of biology, as well as considering which areas of inquiry are yielding the most exciting discoveries. Please join us and scroll along as we revisit a ...
Kim Kee-Pyo KP Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, - - 2014
The manufacturing of clinically relevant cells is a widely used strategy in regenerative medicine. Cahan et al. develop a network biology platform named CellNet to accurately assess the fidelity of such cells and spot aberrant regulatory networks, and Morris et al. apply this platform to improve cell manufacturing.
Lim Kyung-Geun KG Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31 Hyoja-dong, Nam-gu, Pohang, Gyungbuk, 790-784, Republic of - - 2014
A self-organized hole extraction layer (SOHEL) with high work function (WF) is designed for energy level alignment with the ionization potential level of CH3 NH3 PbI3 . The SOHEL increases the built-in potential, photocurrent, and power conversion efficiency (PCE) of CH3 NH3 PbI3 perovskite solar cells. Thus, interface engineering of ...
Luckie Douglas B DB Cystic Fibrosis Research Laboratory, Department of Physiology and Lyman Briggs College, 2100 Biomedical Sciences Bldg., Michigan State University, East Lansing, MI 48824. Electronic address: - - 2014
Cystic Fibrosis (CF) is caused by mutations in the gene for CFTR, a cAMP-activated anion channel expessed in apical membranes of wet epithelia. Since CFTR is permeable to HCO3-, and may regulate bicarbonate exchangers, it is not surprising evidence of changes in extracellular pH (pHo) have been found in CF. ...
Peng Jing J Laboratory of Genetics, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2014
1‑calcium phosphate‑uracil (1‑CP‑U), a synthetic pyrimidine derivative, has been documented to demonstrate a variety of different biological activities. However, the potency and mechanisms of this agent's anti-cancer activity have not been elucidated to date. In the present study, the anti‑cancer effects of 1‑CP‑U were examined in a range of in vitro ...
Gannon Nicholas P NP Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, - - 2014
Exercise has been shown to reduce risk and improve prognosis of several types of cancers. Irisin is a myokine linked to exercise and lean body mass, which is thought to favorably alter metabolism systemically, potentially providing benefit for metabolic disease (including cancer). We evaluated the effects of various concentrations of ...
D'Angelo Leonarda L Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy Center for Applied Biomedical Research (CRBA), S.Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Colorectal cancer (CRC) is one of the major causes of cancer death worldwide. The development of novel anti-CRC agents able to overcome drug resistance and/or off-target toxicity is of pivotal importance. The mammalian target of rapamycin (mTOR) plays a critical role in CRC, regulating protein translation and controlling cell growth, ...
Gudapati Hemanth H Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, - - 2014
Modified laser-induced forward transfer has emerged as a promising bioprinting technique. Depending on the operating conditions and cell properties, laser cell printing may cause cell injury and even death, which should be carefully elucidated for it to be a viable technology. This study has investigated the effects of alginate gelation, ...
Cahan Patrick P Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, - - 2014
Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent powerful approaches to engineer cells for research and regenerative medicine. We have developed CellNet, a network biology platform that more accurately assesses the fidelity of cellular engineering than existing methodologies and generates hypotheses for ...
Bonde Morris Reiner MR USDA_ARS, FDWSRU , 1301 Ditto Ave. , Fort Detrick , Frederick, Maryland, United States , 21702 , 301-619-2343 , 301-619-2880 ; - - 2014
Puccinia horiana Henn., causal agent of the disease commonly known as Chrysanthemum white rust (CWR), is a quarantine-significant fungal pathogen of chrysanthemum in the United States (U.S.) and indigenous to Asia. The pathogen was believed to have been eradicated in the U.S. but recently re-appeared on several occasions in northeastern ...
Chiappalupi Sara S Department of Experimental Medicine, University of Perugia, 06132 Perugia, ItalyInteruniversity Institute of Myology (IIM), - - 2014
Rhabdomyosarcoma is a muscle-derived malignant tumor mainly affecting childhood. The most frequent variant, embryonal rhabdomyosarcoma (ERMS) is characterized by overexpression of the transcription factor, PAX7 which prevents ERMS cells from exiting the cell cycle and terminally differentiating. However, a role for PAX7 in the invasive properties of ERMS cells has ...
Kulj Mihaela - - 2014
During development of recombinant monoclonal antibodies in Chinese hamster ovary (CHO) cells, C-terminal amidated species are observed. C-terminal amidation is catalysed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme known to be expressed in CHO cells. The significant variations between clones during clone selection, and the relatively high content of amidated ...
Wu Xin-Lin XL Xin-Lin Wu, Wan-Xiang Wang, Xing-Kai Meng, Ming-Xing Hou, Pei-De Dong, Jun-Jing Zhang, Zhao-Yang Wang, Department of General Surgery, the Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010059, Inner Mongolian Autonomous Region, - - 2014
To investigate the effects of osteopontin (OPN) gene expression knockdown on colon cancer Lovo cells in vitro. Four candidate small interfering RNA (siRNA) constructs targeting the OPN gene and a scrambled control sequence (NC-siRNA) were synthesized and inserted into a pGPU6/GFP/Neo expression vector. After confirmation by restriction enzyme digestion and ...
Wu Shuang S Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, - - 2014
Plant cells are able to convey positional and developmental information between cells through the direct transfer of transcription factors. One well-studied example of this is the SHORT-ROOT protein, which moves from the stele into the neighboring ground tissue layer to specify endodermis. While it has been shown that SHR trafficking ...
Breunig Hans Georg HG Department of Biophotonics and Laser Technology, Saarland University, Faculty of Mechatronics and Physics, Campus A5.1, 66123, Saarbrücken, Germany; JenLab GmbH, Schillerstr. 1, 07745 Jena, Germany and Science Park 2, Campus D1.2, 66123, Saarbrücken, - - 2014
We present a femtosecond-laser based nanoprocessing system for transient optical cell membrane poration to allow the introduction of foreign molecules into the interior of a cell with very high throughput. In the setup, cells flow through a micro-flow tube for spatial confinement and are simultaneously targeted by fs laser radiation. ...
Castilla Carolina C Hospital Universitario Virgen del Rocio, Instituto de Biomedicina de Sevilla - - 2014
PTTG1 protein, the human securin, has a central role in sister chromatid separation during mitosis and its altered expression has been reported in many tumor types. Paclitaxel is a widely used chemotherapeutic drug, whose mechanism of action is related to its ability to arrest cells in mitosis and the subsequent ...
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