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Zheng Shuyao S Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida College of Medicine, University of Florida, 1275 Center Dr, Room J597, Gainesville, FL, 32610-0275, - - 2014
Clinical onset of type 1 diabetes (T1D) is thought to result from a combination of overt beta cell loss and beta cell dysfunction. However, our understanding of how beta cell metabolic abnormalities arise during the pathogenesis of disease remains incomplete. Despite extensive research on the autoimmune nature of T1D, questions ...
Badowski Michael M Department of Immunobiology, College of Medicine, The University of Arizona, Tucson, Arizona, - - 2014
Cord tissue (CT) storage is promoted as an opportunity to preserve a source of mesenchymal stromal cells (MSCs) for future use. We analyzed maximal MSC yields from fresh and frozen CT including functional capacity after long-term cryopreservation as a means of assessing potential utility. CT was evaluated immediately upon harvest ...
Jongbloets Bart C BC Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, 3451 PM Utrecht, The - - 2014
Semaphorins are secreted and membrane-associated proteins that regulate many different developmental processes, including neural circuit assembly, bone formation and angiogenesis. Trans and cis interactions between semaphorins and their multimeric receptors trigger intracellular signal transduction networks that regulate cytoskeletal dynamics and influence cell shape, differentiation, motility and survival. Here and in ...
Tatematsu Tsutomu T Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, - - 2014
Advances in the molecular segmentation of lung cancer has raised the possibility that neurotrophic tyrosine kinase receptor (NTRK) 1 fusions and NTRK1-3 expression may be promising molecular targets for future therapeutic interventions. We investigated the antitumor effects of a selective pan-NTRK inhibitor, AZD7451, by evaluating its antiproliferative effects on the ...
England Ryan W RW From the Departments of *Surgery, †Obstetrics and Gynecology, and ‡Pathology, College of Physicians and Surgeons, Columbia University, New York, - - 2014
Infantile hemangiomas (IHs) are the most common tumor of infancy, yet there are no Food and Drug Administration-approved therapeutics to date. Recently, the nonselective β-adrenergic-blocker propranolol has been shown to be a safe and effective means of treating IHs, although its mechanism has yet to be elucidated. We have previously ...
Oróstica María L ML Laboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, ChileLaboratorio de Inmunología de la ReproducciónFacultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, Casilla 40, Correo 33, Santiago, ChileCentro para el Desarrollo en Nanociencia y Nanotecnología-CEDENNASantiago, ChileInstituto de Investigaciones Materno-InfantilUniversidad de Chile, Santiago, - - 2014
In the rat oviduct, estradiol (E2) accelerates egg transport by a nongenomic action that requires previous conversion of E2 to methoxyestrogens via catechol-O-methyltranferase (COMT) and activation of estrogen receptor (ER) with subsequent production of cAMP and inositol triphosphate (IP3). However, the role of the different oviductal cellular phenotypes on this ...
Zhang Biao B Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, Nanjing, Jiangsu 210029, P.R. - - 2014
Never in mitosis gene A-related kinase (Nek) 6 is a recently identified Nek that is required for mitotic cell cycle progression; however, the role and mechanism of Nek6 activity during hepatocarcinogenesis is not well known. The aim of this study was to investigate the potential roles and internal mechanism of ...
Zhang Xianqing X Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. - - 2014
The aim of the present study was to investigate the anti‑tumor effect of apogossypolone (ApoG2) on human LNCaP cells in vitro and in vivo. Cell viability was evaluated using an MTT assay. Cell autophagy and apoptosis were detected by flow cytometry and using a terminal deoxynucleotidyl transferase dUTP nick end labeling assay, ...
Lawson Tracy T School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, - - 2014
1064 I. 1064 II. 1066 III. 1066 IV. 1068 V. 1069 VI. 1070 VII. 1070 VIII. 1070 IX. 1071 X. 1072 XI. 1074 XII. 1074 1076 References 1076 SUMMARY: Stomata control gaseous fluxes between the internal leaf air spaces and the external atmosphere. Guard cells determine stomatal aperture and must ...
Gao Qi Q Department of Biochemistry, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. - - 2014
Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor which regulates various cellular functions. The aim of the present study was to analyze the function of PTEN gene expression in squamous cell carcinoma (SCC) cells. This gene exhibits a unique function in cell migration and proliferation during the early ...
Abera Metadel K - - 2014
The importance of cell division models in cellular pattern studies has been acknowledged since the 19th century. Most of the available models developed to date are limited to symmetric cell division with isotropic growth. Often, the actual growth of the cell wall is either not considered or is updated intermittently ...
Dai Bingling B School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Eupolyphaga sinensis Walker has been reported to have anticoagulation, antithrombotic, liver protective and antitumor effects. In the present study, the inhibitory effects on proliferation of A549 human non‑small cell lung cancer cells and the underlying mechanisms were examined. Firstly, three solvents, 70% ethanol, distilled water and 95% ethanol, were used ...
Lin Chuang-Yu CY Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou, Taoyuan, - - 2014
Chitosan is a choice material for scaffolds in regenerative medicine. One of the applications is to bridge the damaged peripheral nerves. Previous studies showed that combination of chitosan conduits and cultured Schwann cells could increase the opportunity for re-connection of broken nerves. It has also been known that Schwann cells ...
Shi Shuqing S Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. - - 2014
The present study aimed to investigate the effect of shikonin on autophagy in BXPC-3 human pancreatic cancer cells and its underlying mechanism. Cell viability was assessed using the Cell Counting Kit-8 assay and the expression of light chain (LC) 3, p62, phosphoinositide 3-kinase (PI3K), Akt, phosphorylated (p)-PI3K and p-Akt was ...
Chaijan Suthidarak S Inter-Departmental Program in Biomedical Sciences, Faculty of the Graduate School, Chulalongkorn University, Bangkok 10330, - - 2014
The function of the extracellular matrix (ECM) in the tumor microenvironment is not limited to forming a barrier against tumor invasion. As demonstrated in pathological specimens, cholangiocarcinoma samples exhibit an enrichment of the ECM surrounding the tumor cells. In this study, we examined involvement of the ECM in the regulation ...
Mu Qitian Q Department of Hematology, Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310003, P.R. China ; Key Laboratory of Hematopoietic Malignancies of Zhejiang Province, Hangzhou, Zhejiang 310003, P.R. China ; Laboratory of Stem Cell Transplantation, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. - - 2014
Adult T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis. Although it has been found that activation of Notch1 signaling occurs in >50% T-ALL patients, γ-secretase inhibitors that target Notch1 signaling are of limited efficacy. However, c-Myc is an important direct target of Notch1 and, thus, c-Myc is another potential ...
Wu Jianyue J Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. - - 2014
The present study aimed to investigate the effect of NVP-BEP800, a novel heat shock protein (Hsp) 90 inhibitor of the 2-aminothieno[2,3-d]pyrimidine class, in combination with radiation on glioblastoma cells. T98G human glioblastoma cells were treated with dimethyl sulfoxide (DMSO), NVP-BEP800, NVP-BEP800 in combination with X-ray irradiation (10 Gy, 20 min), ...
Axelrod Jeffrey D JD Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA - - 2014
A diverse group of researchers working on both plant and animal systems met at a Company of Biologists workshop to discuss 'Coordinating Cell Polarity'. The meeting included considerable free discussion as well as presentations exploring the ways that groups of cells in these various systems achieve coordinated cell polarity. Here, ...
Wang Yajun Y Institute of Respiratory Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524023, P.R. - - 2014
Metformin (Met) has been widely used in hypoglycemic therapy, and it is also able to reduce the incidence of tumors and tumor-related mortality. The present study investigated whether Met could inhibit the proliferation of lung cancer cells and enhance the sensitivity of a cisplatin-resistant lung cancer A549/CDDP cell line to ...
Zhang Wei W School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. - - 2014
An immortalized mouse fetal liver stromal cell line, named KM3, has demonstrated the potential to support the growth and maintenance of human embryonic stem cells (hESCs). In this study, the characteristics of KM3 cells were examined following cryopreservation at -70°C and in liquid nitrogen for 15, 30 and 60 days ...
Wei Cong C Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P.R. - - 2014
The aim of the present study was to investigate whether ultrasound treatment combined with microbubbles inhibits cell invasion and migration in androgen-independent prostate cancer (PCa) cells and to identify the probable mechanism. Ultrasound was used in continuous wave mode at a frequency of 21 kHz and with a spatial-average temporal-average ...
Chaffee Blake R BR Department of Biology, Miami University, Oxford, OH 45056, - - 2014
Lens epithelial cells and early lens fiber cells contain the typical complement of intracellular organelles. However, as lens fiber cells mature they must destroy their organelles, including nuclei, in a process that has remained enigmatic for over a century, but which is crucial for the formation of the organelle-free zone ...
Freund Guillaume G Ecole Supérieure de Biotechnologie de Strasbourg, UMR 7242, CNRS/Université de Strasbourg, Boulevard Sébastien Brant, Illkirch, - - 2014
Intrabodies, when expressed in cells after genetic fusion to fluorescent proteins, are powerful tools to study endogenous protein dynamics inside cells. However, it remains challenging to determine the conditions for specific imaging and precise labelling of the target antigen with such intracellularly expressed antibody fragments. Here, we show that single-chain ...
Huang Xiang X Department of Urology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610041, P.R. - - 2014
Hypoxia-inducible factor (HIF)-1α has been reported to be associated with malignancy in a number of types of cancer. However, the role of HIF-1 α in the regulation of prostate cancer (PCa) growth has yet to be elucidated. The present study aimed to investigate the effect of HIF-1α on the biological ...
Ganji Yasaman Y Faculty of Biomedical Engineering, Amirkabir University of Technology, 424 Hafez Ave., Tehran, Iran. Electronic address: - - 2014
Gold nanotubes/nanowires (GNT/NW) were synthesized by using the template-assisted electrodeposition technique and mixed with castor oil-polyethylene glycol based polyurethane (PU) to fabricate porous composite scaffolds for biomedical application. 100 and 50ppm of GNT/NW were used to synthesize composites. The composite scaffolds were characterized by Fourier transform infrared spectroscopy, dynamic mechanical ...
Xu Kaiwu K Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. - - 2014
Single nucleotide polymorphisms (SNPs) are associated with the development of certain types of cancer. The present study aimed to investigate the association between X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2) SNPs and colorectal cancer (CRC) cell sensitivity to the poly(ADP-ribose) polymerase (PARP) 1 inhibitor olaparib (AZD2281). ...
Tubin Slavisa - - 2014
Abstract Purpose: This in vitro study evaluated the ability of prostate adenocarcinoma (ADC) cells to induce radiation-induced bystander effect (RIBE) exploring the factors that may be responsible and affect its intensity. The idea was to mimic a strong, clinically applicable RIBE that could lead to the development of innovative approaches ...
Faller K K Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United - - 2014
A 4-year old spayed male domestic shorthair cat was presented with a history of circling and behavioral changes. Neurologic examination showed mild proprioceptive deficits. The lesion was localized in the forebrain, and magnetic resonance imaging revealed the presence of a large midline intracranial mass extending from the frontal lobe to ...
Park Eun-Sil ES Department of Biology, Laboratory of Aging and Infertility Research, Northeastern University, Boston, Massachusetts 02115, - - 2014
Several laboratories have independently isolated mitotically active germ cells, termed female germline stem cells (fGSCs) or oogonial stem cells (OSCs), from adult mouse ovaries. However, a recent study from Liu and colleagues using Ddx4-Cre;Rosa26 reporter mice concluded that such germ cells do not exist. Given the disparity in conclusions drawn ...
Qin Qin - - 2014
BackgroundSurvivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we evaluated the radiosensitizaion potential of YM155 in human esophageal squamous cell carcinoma (ESCC).MethodsCell viability was determined by CCK8 assay. The ...
Li Yubin Y Department of Biosynthesis & The Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of - - 2014
Poly(amidoamine) (PAMAM) dendrimers are proposed as one of the most promising nanomaterials for biomedical applications because of their unique tree-like structure, monodispersity and tunable properties. In this study, we found that PAMAM dendrimers could induce the formation of autophagosomes and the conversion of microtubule-associated protein 1 light chain 3 (LC3) ...
Fernandez-Garcia Elisa E Nanomaterials and Nanotechnology Research Center (CINN), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Oviedo (UO), El Entrego, Spain - - 2014
Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3 Y-TZP/Ti materials with 25, 50 and 75 vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their ...
Trost A A Ophthalmology/Optometry, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020, Salzburg, Austria, - - 2014
Doublecortin (DCX) is predominantly expressed in neuronal precursor cells and young immature neurons of the developing and adult brain, where it is involved in neuronal differentiation, migration and plasticity. Moreover, its expression pattern reflects neurogenesis, and transgenic DCX promoter-driven reporter models have been previously used to investigate adult neurogenesis. In ...
Koekemoer T C TC Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, 6031, South - - 2014
To investigate anti-proliferatory activity of a selected N,N-[(8-hydroxyquinoline)methyl]-substituted benzylamine (JLK1486) on melanoma cells and to characterize its mechanism of cell population growth inhibition. In vitro cultures of B16F10 (mouse melanoma) cells were used as a model to characterize anti-proliferatory activity of JLK1486 using MTT growth assay, trypan blue viability assessment, ...
Kulkarni Rajan P RP Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Box 951600, Los Angeles, California 90095, USA. - - 2014
We highlight recent reports using microfluidic systems to perform single-cell analysis. It has been demonstrated on numerous occasions that population averages are often not representative of single-cell behavior. These differences in behavior can be caused by stochastic fluctuations in temporal response, changes in the surrounding instructive environment, or hard-coded genetic ...
Chera Simona S Department of Genetic Medicine &Development, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva-4, - - 2014
Total or near-total loss of insulin-producing β-cells occurs in type 1 diabetes. Restoration of insulin production in type 1 diabetes is thus a major medical challenge. We previously observed in mice in which β-cells are completely ablated that the pancreas reconstitutes new insulin-producing cells in the absence of autoimmunity. The ...
Egger Michael M University of Louisville, Surgery, Louisville, Kentucky, United States ; - - 2014
Melanoma exhibits variable resistance to the alkylating agent temozolomide (TMZ). We evaluated the potential of adenovirus expressing forkhead human transcription factor like 1 triple mutant (Ad-FKHRL1/TM) to sensitize melanoma cells to TMZ. Four melanoma cell lines were treated with Ad-FKHRL1/TM and TMZ, alone or in combination. Apoptosis was assessed by ...
Chen Zhi-Jie - - 2014
The discovery of hydrogen sulfide (H2S) as a novel gasotransmitter for cell signaling and other pathophysiological processes has spurred tremendous interest in developing analytical methods for its detection in biological systems. Herein, we report the development of a highly responsive and selective genetically encoded H2S probe, hsGFP, for the detection ...
Feng Xiujing X Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, 210014, - - 2014
Production of human α-lactalbumin (hα-LA) transgenic cloned dairy goats has great potential in improving the nutritional value and perhaps increasing the yield of dairy goat milk. Here, a mammary-specific expression vector 5A, harboring goat β-lactoglobulin (βLG) promoter, the hα-LA gene, neo(r) and EGFP dual markers, was constructed. Then, it was ...
Zhu Jiaoyan J Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, People's Republic of - - 2014
Interface states influence the operation of nanocrystal (NC) solar cell carrier transport, recombination and energetic mechanisms. In a typical CdTe NC solar cell with a normal structure of a ITO/p-CdTe NCs/n-acceptor (or without)/Al configuration, the contact between the ITO and CdTe is a non-ohm contact due to a different work ...
Chowdhury Jamil J ARC Centre of Excellence in Plant Cell Walls, School of Agriculture, Food and Wine, University of Adelaide, Waite Campus, Glen Osmond, SA, 5064, - - 2014
In plants, cell walls are one of the first lines of defence for protecting cells from successful invasion by fungal pathogens and are a major factor in basal host resistance. For the plant cell to block penetration attempts, it must adapt its cell wall to withstand the physical and chemical ...
Turrioni Aps - - 2014
SUMMARY Objective : The aim of this study was to investigate the effects of transdentinal irradiation with different light-emitting diode (LED) parameters on odontoblast-like cells (MDPC-23). Methods and Materials : Human dentin discs (0.2 mm thick) were obtained, and cells were seeded on their pulp surfaces with complete culture medium ...
Schmitt J J Department of Biology, University of York, York, YO10 5DD, - - 2014
Background:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethanolamine (Etn) metabolites released to the medium.Methods:Prostate epithelial cell lines P4E6, LNCaP and ...
Bellini Marco M Institute of Chemistry of Organometallic Compounds, ICCOM-CNR, Polo Scientifico Area CNR, Via Madonna del Piano 10, 50019 Sesto Fiorentino - - 2014
Invited for this month's cover are the groups of Hansjörg Grützmacher at ETH in Zürich and Francesco Vizza at ICCOM-CNR in Florence. The image shows in an allegoric form an organometallic fuel cell releasing energy and fine chemicals produced through the electrooxidation of renewable diols. The Communication itself is available ...
Kaistha B P BP Department of Medicine, Division of Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, - - 2014
Background:Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hardly improved, warranting the need to identify novel targets for therapeutic approaches.Methods:Quantitative ...
Alamri A A Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec, QC, Canada; Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi - - 2014
Smoking cigarettes increases the risk of oral tissue damage leading to periodontal disease. Gingival fibroblasts, the predominant cell type inhabiting gingival connective tissue, play a critical role in remodeling and maintaining gingival structure. The objective of this study was to investigate the effect of long-term exposure to cigarette smoke on ...
He Yingzi Y Department of Otolaryngology, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, People's Republic of - - 2014
Aminoglycoside-induced hair cell loss is a major cause of hearing impairment in children and deserves more attention in medical research. Epigenetic mechanisms have been shown to protect hair cells from ototoxic drugs. In this study, we focused on the role of dimethylated histone H3K4 (H3K4me2) in hair cell survival. To ...
Park Ji Hun JH Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon 305-701 - - 2014
Single-cell encapsulation promises the cytoprotection of the encased cells against lethal stressors, reminiscent of the sporulation process in nature. However, the development of a cytocompatible method for chemically mimicking the germination process (i.e., shell degradation on-demand) has been elusive, despite the shell degradation being pivotal for the practical use of ...
Dinić Jelena J Institute for Biological Research, Department of Neurobiology, University of Belgrade, Belgrade, - - 2014
Diarylheptanoids belong to polyphenols, a group of plant secondary metabolites with multiple biological properties. Many of them display antioxidative, cytotoxic, or anticancer actions and are increasingly recognized as potential therapeutic agents. The aim of this study was to evaluate antioxidant and cytoprotective activity of two diarylheptanoids: platyphylloside 5(S)-1,7-di(4-hydroxyphenyl)-3-heptanone-5-O-β-D-glucopyranoside (1) and ...
Marinowic D R DR Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul. Brazil, Porto Alegre, 90610-000, Brazil, - - 2014
Human umbilical cord blood is an attractive source of stem cells; however, it has a heterogeneous cell population with few mesenchymal stem cells. Cell reprogramming induced by different methodologies can confer pluripotency to differentiated adult cells. The objective of this study was to evaluate the reprogramming of fibroblasts and their ...
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