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Gakhar Gunjan G Department of Medicine, Weill Cornell Medical College, New York City, NY, - - 2014
Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. Cationic polymers effects on PC3 prostate cancer cells and normal prostate ...
Ortega-Calderón Yasmín Nansi YN Laboratory of Cell Biology, Department of Physiology, National Institute of Cardiology, Ignacio Chávez, - - 2014
Dehydroepiandrosterone (DHEA), an adrenal steroid which is most abundant in human plasma, has a protective role against several types of cancer; however, its mechanisms of action are unknown. We evaluated the effect of DHEA on the proliferation and migration of three cell lines derived from cervical cancer. Cell proliferation was ...
Saibu Morounke M Department of Biotechnology, University of the Western Cape, Bellville, South - - 2014
Quinone-containing compounds can induce cell death in cancer cells and are, therefore, promising lead compounds for the development of novel anti-cancer drugs. In the present study, we evaluated the cytotoxic effects of fifteen novel synthetic quinone-containing compounds in cell cultures in an attempt to establish structure/activity relationships for these compounds. ...
VON Schulz-Hausmann Sarah Annette SA University Hospital Bonn, Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Bonn, - - 2014
Advanced renal cancer still has a very poor prognosis. In this regard recent investigations demonstrated a constitutive activation of the Wnt signaling pathway in renal cell carcinoma (RCC) thereby promoting an exaggerated cell proliferation. Especially, β-catenin overactivation and the functional loss of endogenous Wnt antagonists are associated with RCC carcinogenesis ...
Umebayashi Masayo M Fukuoka General Cancer Clinic, Fukuoka, - - 2014
Cancer stem-like properties of various types of cancer, including pancreatic cancer, one of the most aggressive types, correlate with metastasis, invasion, and therapeutic resistance. More importantly, chemoresistance in cancer stem-like cells (CSLCs) is a critical problem for eradication of pancreatic cancer. Several cell surface markers, such as CD44 and epithelial ...
Wang Tongpeng T Department of Mathematics, Institute of Systems Biology, Shanghai University, Shanghai 200444, People's Republic of China. - - 2014
Simple mutual-inhibition networks are frequently occurring motifs in transcriptional regulatory networks for cell lineage commitment. Stable attractors represent cell commitment states. However, how progenitor-specific transcription factors stabilise progenitor cells and commit them to different cell fates remains unexplained. In this study, the authors represent the cell commitment motifs composed of ...
Blair Peter J PJ Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, - - 2014
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune cells and smooth muscle cells (SMCs). Over the last number of years the complexity of the interactions between these cell ...
Belova O V OV Research Institute of Physico-Chemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia, - - 2014
Subfraction with a molecular weight >250 kDa isolated from porcine skin and inhibiting the proliferation of A431 human carcinoma epidermoid cells was purifi ed by DEAE 32 anion exchange chromatography with NaCl concentration step-gradient. The effects of the initial subfraction and fractions obtained by separation in DEAE 32 on the ...
Momot Dariya D Carcinogen-DNA Interactions Section, LCBG, National Cancer Institute, NIH, Bethesda, - - 2014
The nucleoside reverse transcriptase inhibitor zidovudine (AZT) induces genotoxic damage that includes centrosomal amplification (CA > 2 centrosomes/cell) and micronucleus (MN) formation. Here we explored these end points in mice deficient in DNA repair and tumor suppressor function to evaluate their effect on AZT-induced DNA damage. We used mesenchymal-derived fibroblasts cultured from ...
Hong L L Department of Oncology, Huai He Hospital Affiliated to Henan University, Henan, - - 2014
The objective of the present study was to examine the antitumor efficacy of the ethanol extract from Artemisia dracunculus as well as the compounds isolated from it on cultured EC‑109 esophageal squamous cell carcinoma (ESCC) cells. Apoptotic activities of the compounds were also studied using flow cytometry. EC‑109 esophageal cancer ...
Zuo Chuantian C National Center for Nanoscience and Technology, Beijing 100190, China. - - 2014
The light-absorbing perovskite layer fabricated using the NH4Cl additive shows high crystallinity and better morphology. The resulting solar cells gave a decent power conversion efficiency of 9.93% and a fill factor record of 80.11%. This work provides a very simple but effective approach to enhance the power conversion efficiency of ...
Nistal Manuel M a Hospital La Paz, Universidad Autónoma de Madrid, - - 2014
Abstract The appropriate interpretation of testicular biopsies from infants and children we requires to keep in mind that the testis, as the rest of the child, is an organ in dynamic development, undergoing significant remodeling from birth to puberty in most of its components, featuring active and variably regulated proliferation ...
Eliaš Ján J UPMC, Laboratoire Jacques-Louis Lions, 4 Place Jussieu, F-75005 Paris, France & INRIA Paris-Rocquencourt, MAMBA project-team, Paris and Rocquencourt, - - 2014
The intracellular signalling network of the p53 protein plays important roles in genome protection and the control of cell cycle phase transitions. Recently observed oscillatory behaviour in single cells under stress conditions has inspired several research groups to simulate and study the dynamics of the protein with the aim of ...
Renju G L GL Department of Biochemistry, University of Kerala, Trivandrum, - - 2014
Even though the role of lycopene from tomato (trans form) in controlling prostate cancer was reported, lycopene (cis and trans 60:40) isolated from green algae Chlorella marina was not reported so far. The present study aimed to assess the anti-proliferative and apoptotic effect of lycopene from a new source and ...
Ge Yangyang Y Department of Radiation Oncology, Nantong Tumor Hospital, Nantong University, Nantong, - - 2014
Radiation therapy is widely used in esophageal squamous cell carcinoma (ESCC). Promoting radiation sensitivity is important. Recent studies have shown that fenofibrate can inhibit the growth of several cancer lines and hypoxia-inducible factor-1α (HIF-1α) expression in MCF-7 cells. However, few studies on the radiosensitive effect of fenofibrate on ESCCs under ...
Anttonen Tommi T Department of Biosciences, University of Helsinki, P.O. Box 56 (Viikinkaari 1), 00014, Helsinki, - - 2014
Hair cell death is a major cause of hearing impairment. Preservation of surface barrier upon hair cell loss is critical to prevent leakage of potassium-rich endolymph into the organ of Corti and to prevent expansion of cellular damage. Understanding of wound healing in this cytoarchitecturally complex organ requires ultrastructural 3D ...
Lee Jaewon J Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, - - 2014
A donor-acceptor conjugated copolymer enables the formation of nanowire systems that can be successfully introduced into bulk-heterojunction organic solar cells. A simple binary solvent mixture that makes polarity control possible allows kinetic control over the self-assembly of the crystalline polymer into a nanowire structure during the film-forming process. The enhanced ...
Gopalakrishnan Natarajan N Unit of Biochemistry, Department of Zoology, School of Life Sciences, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, - - 2014
The Wnt and Notch1 signaling pathways play major roles in intestinal development and tumorigenesis. Sub-cellular localization of β-catenin has been implicated in colorectal carcinogenesis. However, the β-catenin and Notch intracellular domain (NICD) interaction has to be addressed. Immunohistochemistries of β-catenin, NICD, and dual immunofluorescence of β-catenin and NICD were analyzed ...
Custódio Catarina A - - 2014
We present a phototriggerable system that allows spatiotemporal controlled attachment of selected cell types to a biomaterial using immobilized antibodies that specifically target individual cell phenotypes. o-nitrobenzyl caged-Biotin was used to functionalize chitosan membranes and mediate site-specific coupling of streptavidin and biotinylated antibodies after light activation. The ability of this ...
Kim Dae Sung DS Laboratory of Molecular Plant Pathology, College of Life Sciences and Biotechnology, Korea University, Anam-dong, Sungbuk-ku, Seoul, 136-713, Republic of - - 2014
Pepper CaMLO2 specifically interacts with CaCaM1 and translocates cytoplasmic CaCaM1 to the plasma membrane, leading to the suppression of Xanthomonas AvrBsT-triggered Ca (2+) influx, hypersensitive cell death and defense responses. Pathogen-induced cell death is closely linked with disease susceptibility and resistance in plants. Pepper (Capsicum annuum) mildew resistance locus O ...
Shawky Eman E a Department of Pharmacognosy , Faculty of Pharmacy, University of Alexandria , Alkhartoom Square, Alexandria 21521 , - - 2014
This study compares the chloroform extracts of bulbs and roots of Narcissus papyraceus Ker Gawl. and Narcissus tazetta L. The cytotoxicity of the plant extracts was evaluated against human hepatocellular carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) in comparison to doxorubicin. The extracts from the after-flowering (AF) ...
Wang Ming M The Cardiology Department of Chongqing Hospital of Traditional Chinese Medicine and Chongqing the First Hospital, Chongqing, 400021, - - 2014
To observe the time-effect relation of extracts from ginseng, notoginseng and chuanxiong on angiotensin II (Ang II)-induced senescence of vascular endothelial cells and explore the feature of Chinese medicine against vascular diseases. Human umbilical vein endothelial cells (HUVECs) cultured in vitro were stimulated with 10(-6) mol/L AngII to induce cell ...
Zhu Ronghua - - 2014
Objective: The aims of this study were to observe the apoptosis effects of tetrandrine on human gallbladder carcinoma cell line (SGC-996), and to explore its related mechanism. Methods: First, the anti-proliferative activities of tetrandrine on SGC-996 cells were determined by using the MTT assays. Then, cell cycle changes were detected ...
Lu Yi-Ching YC Department of Physiology and Pharmacology, Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kuei-Shan, Tao-Yuan 33302, Taiwan, Republic of China. - - 2014
Nanoparticles may serve as carriers in targeted therapeutics; interaction of the nanoparticles with a biological system may determine their targeting effects and therapeutic efficacy. Epigallocatechin-3-gallate (EGCG), a major component of tea catechins, has been conjugated with nanoparticles and tested as an anticancer agent. We investigated whether EGCG may enhance nanoparticle ...
Jiang Wenting - - 2014
The poor permeability of glioma parenchyma represents a major hurdle for anti-glioblastoma drug delivery. In this study, gracilaria lemaneiformis polysaccharid (GLP), which has a high binding affinity to αvβ3 integrin overexpressed in glioma cells, was employed to functionalize selenium nanoparticles (SeNPs) to achieve anti-glioblastoma efficacy. GLP-SeNPs showed satisfactory size distribution, ...
Golson Maria L ML Tennessee Valley Healthcare System Department of Veteran Affairs, Nashville, - - 2014
The forkhead box transcription factor FoxM1, a positive regulator of the cell cycle, is required for β-cell mass expansion postnatally, during pregnancy, and after partial pancreatectomy. Upregulation of full-length FoxM1, however, is unable to stimulate increases in β-cell mass in unstressed mice or after partial pancreatectomy, likely due to lack ...
Hosokawa Masahito - - 2014
A straightforward in vivo monitoring technique for biomolecules would be an advantageous approach for understanding their spatiotemporal dynamics in living cells. However, the lack of adequate probes has hampered the quantitative determination of the chemical composition and metabolomics of cellular lipids at single-cell resolution. Here, we describe a method for ...
Qiu Yongcai - - 2014
Nitrogen-doped graphene (NG) is a promising conductive matrix material for fabricating high performance Li/S batteries. Here we report a simple, low-cost, and scalable method to prepare an additive-free nanocomposite cathode in which sulfur nanoparticles are wrapped inside the NG sheets (S@NG). We show that the Li/S@NG can deliver high specific ...
Hamm Rebecca R Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, - - 2014
Resistance of cancer cells towards chemotherapy is the major cause of therapy failure. Hence, the evaluation of cellular defense mechanisms is essential in the establishment of new chemotherapeutics. Archazolid B, a novel vacuolar H(+)-ATPase inhibitor, displayed cytotoxicity in the low nanomolar range on a panel of different tumor cell lines. ...
Zhao Ziqi - - 2014
3D multicellular spheroids (MCSs) mimic the structure and function of real tissue much better than the conventional 2D cell monolayers, however, their application was severely hindered by difficulties in their generation. An ideal method for MCS fabrication should produce spheroids with narrow size distribution and allow for control over their ...
Feldman Steven A SA National Cancer Institute, Surgery Branch , 10 Center Drive, MSC 1201 , Bldg. 10, ACRF, 1B37A , Bethesda, Maryland, United States , 20892 , 3014964269 , 3014804968 ; - - 2014
Efforts to improve the biosafety of γ-retroviral mediated gene therapy have resulted in a shift towards the use of self-inactivating (SIN) γ-retroviral vectors. However, scale-up and manufacturing of such vectors requires significant optimization of transient transfection-based processes or development of novel platforms for the generation of stable producer cell clones. ...
Chiu M M Department of Biomedical Biotechnological and Translational Sciences (SBiBiT), University of Parma, Parma, - - 2014
Background:A subset of human hepatocellular carcinomas (HCC) exhibit mutations of β-catenin gene CTNNB1 and overexpress Glutamine synthetase (GS). The CTNNB1-mutated HCC cell line HepG2 is sensitive to glutamine starvation induced in vitro with the antileukemic drug Crisantaspase and the GS inhibitor methionine-L-sulfoximine (MSO).Methods:Immunodeficient mice with subcutaneous xenografts of the CTNNB1-mutated ...
Wong Hui Chyn HC Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, - - 2014
3,19-(3-Chloro-4-fluorobenzylidene)andrographolide (SRJ23), a new semisynthetic derivative of andrographolide (AGP), exhibited selectivity against prostate cancer cells in the US National Cancer Institute (NCI) in vitro anti-cancer screen. Herein, we report the in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis induced by SRJ23. 3-(4,5-Dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay ...
So Eui Young - - 2014
BRAT1 (BRCA1-associated ATM activator 1) interacts with both BRCA1, ATM and DNA-PKcs, and has been implicated in DNA damage responses. However, based on our previous results, it has been shown that BRAT1 may be involved in cell growth and apoptosis, besides DNA damage responses, implying that there are undiscovered functions ...
Sun Yang Y Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, One Blackfan Circle, 6th Floor, Boston, MA, 02115, - - 2014
Lymphangioleiomyomatosis (LAM) is a female-predominant lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis 2 (TSC2) mutations, leading to mTORC1 hyperactivation. The gender specificity of LAM suggests that female hormones contribute to disease progression. Clinical findings indicate that estradiol exacerbates LAM behaviors and symptoms. ...
Shah Mansi K MK College of Pharmacy and Health Sciences, St. John's University , Queens, NY , - - 2014
Abstract Enhanced oral bioavailability of poorly aqueous soluble drugs encapsulated in solid lipid nanoparticles (SLNs) via lymphatic delivery has been documented. Since no in-vitro lymphoid tissue is currently available, human excised Caco-2 cell monolayer could be alternative tissue for development of an in-vitro model to be used as a screening ...
Cheng Xin-Bing XB Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, PR - - 2014
Entrapment of free lithium in a 3D fibrous Li7 B6 framework allows LiB nanostructured anodes with stable interfaces between the electrolyte and the electrode, which retards the formation of lithium dendrites. A lithium-sulfur cell with a nanostructured anode is created with a high Coulombic efficiency and high capacity retention rate ...
Baldini Enke E E Baldini, Department of Experimental Medicine, "Sapienza" University of Rome, Rome, - - 2014
Aurora kinases are serine/threonine kinases that play an essential role in cell division. Their aberrant expression and/or function induce severe mitotic abnormalities resulting in either cell death or aneuploidy. Aurora kinases are often found overexpressed in several malignancies among which the anaplastic thyroid carcinoma (ATC). We previously demonstrated the in ...
Hawkins Kate K Stem Cell Research Group, The University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT, - - 2014
Mouse embryonic stem (mES) cells and epiblast stem cells (EpiSCs) represent the naïve and primed pluripotent states respectively. These cells self-renew via distinct signalling pathways and can transition between the two states in the presence of appropriate growth factors. Manipulation of signalling pathways has therefore allowed the isolation of novel ...
Miyai Tomohiro T Laboratory for Immune Regeneration,Graduate School of Frontier Biosciences, Osaka University, Yamada-oka, Suita, Osaka 565-0871, - - 2014
The immune system is influenced by the vital zinc (Zn) status, and Zn deficiency triggers lymphopenia; however, the mechanisms underlying Zn-mediated lymphocyte maintenance remain elusive. Here we investigated ZIP10, a Zn transporter expressed in the early B-cell developmental process. Genetic ablation of Zip10 in early B-cell stages resulted in significant ...
Jadidian Armon A Department of Otolaryngology-Head and Neck Surgery, University of Florida College of Medicine, Gainesville, Florida, - - 2014
Mitoquinone (MitoQ) attenuates aminoglycoside (AG)-induced upregulation of the proapoptotic molecules Bak and harakiri (Hrk) and decreases the percentage of apoptotic House Ear Institute Organ of Corti 1 (HEI-OC1) cells. The primary mechanism of AG ototoxicity is the formation of reactive oxygen species, which leads to hair cell death via apoptotic ...
Nguyen Khanh-Quynh N KQ Rutgers Biomedical and Health Sciences, United - - 2014
MERTK, a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases, has complex and diverse roles in cell biology. On the one hand, knockout of MERTK results in age-dependent autoimmunity characterized by failure of apoptotic clearance, while on the other, MERTK overexpression in cancer drives classical oncogene pathways ...
Tao Jie J Jie Tao, Xin-Sen Xu, Kai Qu, Rui-Tao Wang, Fan-Di Meng, Ji-Chao Wei, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, - - 2014
To investigate the effect of knockdown of Forkhead box M1 (FoxM1) on the proliferation and invasion capacities of human gallbladder carcinoma (GBC)-SD cells. Four FoxM1 shRNAs were transfected into GBC-SD cells with Lipofectamine 2000 to select the appropriate shRNA for down-regulation of FoxM1. A recombinant lentivirus for shFoxM1 (Lv-shFoxM1), which ...
Zych Jaiesa J 1 Instituto Carlos Chagas , Fiocruz-Paraná, Curitiba, Brazil - - 2014
Although fibroblasts and multipotent stromal/stem cells, including adipose-derived stromal cells (ADSCs), have been extensively studied, they cannot be clearly distinguished from each other. We, therefore, investigated the cellular and molecular characteristics of ADSCs and fibroblasts. ADSCs and fibroblasts share several morphological similarities and surface markers, but were clearly found to ...
Rock Jason R JR Department of Anatomy, University of California, San Francisco, CA 94143, USA. Electronic address: - - 2014
Mammalian lungs are comprised of conducting airways and alveoli. How the distinct epithelial linings of these two zones are differentially specified and maintained is not fully understood. In this issue of Developmental Cell, two groups find critical roles for the Hippo pathway in regulation of lung progenitor cell differentiation.
Chen Jieyan V JV Department of Biomedical Sciences, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, - - 2014
In this issue of Developmental Cell, Fong et al. (2014) present evidence for a model of centriole duplication whereby the cartwheel-the starting building block in centriole biogenesis-assembles within the lumen of the mother centriole before templating the daughter centriole to ensure a single duplication event per cell cycle.
Bergström G G Division of Biotechnology, Dept. of Physics, Chemistry and Biology (IFM), Linköping University, 581 83 Linköping, Sweden. - - 2014
Macroporous gelatin beads (CultiSpher™ microcarriers) provide a convenient method for rapidly and reliably introducing cells cultured ex situ into a microfluidic device, where the spheres create a 3D environment for continued cell proliferation. We demonstrate the usefulness of this technique with a proof-of-concept viability analysis of cardiac cells after treatment ...
Lodhia Kunal A KA Department of Oncology, University of Oxford, Oxford, - - 2014
It is common practice to irrigate the operative site following tumor resection during major head and neck surgery. A variety of irrigation solutions are used, but there are few data on their relative efficacies in this context. The effect of different irrigation solutions on cell survival was assessed by clonogenic ...
Wei Jianfeng - - 2014
We investigated the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), alone and in combination, on apoptosis and intracellular calcium concentration in hepatocellular carcinoma (HepG2) cells. We used HepG2 cells to test the effects of ATRA and ATO, individually and in combination, on cell proliferation, apoptosis, and intracellular-free ...
Subrahmanyam Priyanka B PB Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD - - 2014
NKT cells are a unique subset of T cells that recognize glycolipid Ags presented in the context of CD1d molecules. NKT cells mount strong antitumor responses and are a major focus in developing effective cancer immunotherapy. It is known that CD1d molecules are constantly internalized from the cell surface, recycled ...
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