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Gui Meng-Cui MC Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, - - 2014
Autophagy dysregulation, mitochondrial dynamic abnormality and cell cycle re-entry are implicated in the vulnerable neurons of patients with Alzheimer's disease. This study was designed to testify the association among autophagy, mitochondrial dynamics and cell cycle in dividing neuroblastoma (N2a) cells. The N2a cells were cultured in vitro and treated with ...
Qiao Peng-Yan PY Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China; Beijing Key Lab of Fine Ceramics, Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China; Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China; National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing 100081, - - 2014
Objective: To deliver cells deep into injectable calcium phosphate cement (CPC) through alginate-chitosan (AC) microcapsules and investigate the biological behavior of the cells released from microcapsules into the CPC. Methods: Mouse osteoblastic MC3T3-E1 cells were embedded in alginate and AC microcapsules using an electrostatic droplet generator. The two types of ...
Soza-Ried Cristian C Vertebrate Development and Developmental Genetics Laboratories, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, - - 2014
Formation of somites, the rudiments of vertebrate body segments, is an oscillatory process governed by a gene-expression oscillator, the segmentation clock. This operates in each cell of the presomitic mesoderm (PSM), but the individual cells drift out of synchrony when Delta/Notch signalling fails, causing gross anatomical defects. We and others ...
Kus Arkadiusz A Warsaw University of Technology, Institute of Micromechanics and Photonics, Photonics Engineering Division, Faculty of Mechatronics, Sw. A. Boboli 8 Street, 02-525 Warsaw, - - 2014
ABSTRACT. A successful application of self-interference digital holographic microscopy in combination with a sample-rotation-based tomography module for three-dimensional (3-D) label-free quantitative live cell imaging with subcellular resolution is demonstrated. By means of implementation of a hollow optical fiber as the sample cuvette, the observation of living cells in different 3-D ...
Fleurie Aurore A Bases Moléculaires et Structurales des Systèmes Infectieux, IBCP, Université Lyon 1, CNRS, UMR 5086, Lyon, - - 2014
Despite years of intensive research, much remains to be discovered to understand the regulatory networks coordinating bacterial cell growth and division. The mechanisms by which Streptococcus pneumoniae achieves its characteristic ellipsoid-cell shape remain largely unknown. In this study, we analyzed the interplay of the cell division paralogs DivIVA and GpsB ...
Chao Wang W Department of Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. - - 2014
Resveratrol (RE), a phytoestrogen, has antiestrogenic properties. Estrogen plays a key role in the development and progression of pituitary prolactinoma. Moreover, RE is a potent cancer chemopreventive agent that inhibits the initiation, promotion and progression of carcinogenesis. The present study investigated the antitumor effects of RE on GH3 pituitary tumor ...
Li Juan J College of Animal Science and Technology, Nanjing Agricultural University, Nanjing Weigang No. 1, Jiangsu Province, China. Electronic address: - - 2014
Epigenetic instability of donor cells due to long-term in vitro culture may influence the success rate of subsequent somatic cell nuclear transfer (SCNT). Therefore, the present study was designed (1) to investigate the epigenetic changes after prolonged culture in vitro of porcine embryonic germ (EG) cells, including differences in expression ...
Vandresen Fábio F Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Maringá, Av. Colombo, 5790, CEP 87020-900, Maringá, PR, Brazil. Electronic address: - - 2014
In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. ...
Dulińska-Molak Ida - - 2014
With a range of biological properties, single-walled carbon nanotubes (SWCNTs) are a promising material for nanobiotechnology. Concerns about their potential effect on human health have led to the interest in understanding the interaction between SWCNTs and cells. There are many reports showing the potential cellular effects of SWCNTs but this ...
Cipriano Aaron F - - 2014
The objective of this study was to investigate the adhesion and morphology of bone marrow derived stromal cells (BMSCs) on bulk titanium (Ti) substrates with precisely-patterned surfaces consisting of groove-based gratings with groove widths ranging from 50 micro m down to 0.5 micro m (500 nm). Although it is well ...
Guo Dawei - - 2014
Several studies have suggested that silver nanoparticles (AgNPs) have the potential to treat human cancers, including leukemia. However, the detailed cellular mechanisms for AgNPs to inhibit the growth of leukemic cells and their efficacy on clinical isolates of leukemic patients are not elucidated. In this study, the cellular uptake and ...
Park M H - - 2014
InGaAs-capped InAs quantum dots (QDs) and InAs QDs were adopted for the study of the effects through growth temperature and the band structure of InAs QDs on the performance of GaAs-based QD solar cell. It has been shown that the defects due to low temperature growth resulted in the decrease ...
Patki Mugdha M Barbara Ann Karmanos Cancer Institute, and Department of Oncology, Wayne State University, Detroit, - - 2014
Pemetrexed is an S-phase targeted drug in front-line or maintenance therapy of advanced nonsquamous non-small-cell lung cancer (NSCLC) but methods are needed for predicting the drug response. Dexamethasone is typically administered the day before, the day of, and the day after pemetrexed. As dexamethasone strongly regulates many genes including p53 ...
Willkomm Lena L German Sport University Cologne, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. Electronic address: - - 2014
Satellite cells (SCs) are the resident stem cells of skeletal muscle tissue which play a major role in muscle adaptation, e.g. as a response to physical training. The aim of this study was to examine the effects of an intermittent lactate (La) treatment on the proliferation and differentiation of C2C12 ...
Adams M N MN Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, - - 2014
Many cancers are dependent on inappropriate activation of epidermal growth factor receptor (EGFR), and drugs targeting this receptor can improve patient survival, although benefits are generally short-lived. We reveal a novel mechanism linking EGFR and the membrane-spanning, cancer-promoting protein CDCP1 (CUB domain-containing protein 1). Under basal conditions, cell surface CDCP1 ...
Zhang Shu-Yong SY Laboratory of Receptor-based Bio-medicine, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, - - 2014
Aim:GPR119 is a G protein-coupled receptor (GPCR) that is highly expressed in pancreatic β-cells and intestinal L-cells and facilitates glucose-stimulated insulin secretion (GSIS). GPR119 may represent a novel target for the treatment of metabolic disorders. Here, we sought to identify novel small-molecule GPR119 agonists.Methods:A cell-based high-throughput screening assay was established ...
Zhang Li L School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. - - 2014
Aloperine (ALO) is a quinolizidine alkaloid extracted from the leaves of Sophora alopecuroides (S. alopecuroides) and possesses anti-inflammatory, anti-allergenic, antitumor, and antiviral effects. In this study, when compared with seven other types of alkaloids extracted from S. alopecuroides, ALO treatment produced the most potent effects against HCT116 colon cancer cell types. ALO ...
Kim Younjoo Y Division of Gastroenterology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, - - 2014
Aberrant Hedgehog (HH) signaling activation is important in cancer growth and mediates the interaction between cancer cells and the surrounding stromal cells. This study investigated the role of HH signaling on the growth of cholangiocarcinoma (CC), focusing on the interaction of CC cells with stromal cells. To evaluate the interaction ...
O'Flanagan C H CH School of Biochemistry and Cell Biology, BioSciences Institute, University College Cork, Cork, - - 2014
PINK1 (phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced kinase 1), a Parkinson's disease-associated gene, was identified originally because of its induction by the tumor-suppressor PTEN. PINK1 promotes cell survival and potentially metastatic functions and protects against cell stressors including chemotherapeutic agents. However, the mechanisms underlying PINK1 function in ...
Yang Jie J National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210093, P. R. China. - - 2014
In situ grown nickel sulfide and cobalt sulfide hierarchical nanospheres on F-doped SnO2 (FTO) substrates exhibited comparable catalytic activities to sputtering Pt on the counter electrodes for dye-sensitized solar cells (DSSCs). The fresh cells with the nickel sulfide and cobalt sulfide on the counter electrodes could reach power conversion efficiencies ...
Brinkmann Jenny J MESA+ Institute for Nanotechnology and Department of Science and Technology, Laboratory Group of Bioinspired Molecular Engineering, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands. - - 2014
This article reviews the state of the art in the development of strategies for generating supramolecular systems for dynamic cell studies. Dynamic systems are crucial to further our understanding of cell biology and are consequently at the heart of many medical applications. Increasing interest has therefore been focused recently on ...
Gallaud Emmanuel E Cytoskeleton and Cell Proliferation, 2 Tubulin and Interacting Proteins, and 3 Spatio-temporal Regulation of Transcription, Biosit, Université de Rennes I, Centre National de la Recherche Scientifique, UMR 6290, 35043 Rennes, - - 2014
The mitotic spindle is crucial to achieve segregation of sister chromatids. To identify new mitotic spindle assembly regulators, we isolated 855 microtubule-associated proteins (MAPs) from Drosophila melanogaster mitotic or interphasic embryos. Using RNAi, we screened 96 poorly characterized genes in the Drosophila central nervous system to establish their possible role ...
Bhat Zeenat Yousuf ZY 1 Division of Nephrology, Department of Internal Medicine, Wayne State University , Detroit, - - 2014
Acute rejection (AR) includes T-cell-mediated and antibody-mediated rejection. The inflammatory infiltrate comprised not only T cells but also varying amounts of B cells (CD20(+)) and plasma cells (CD138(+)). The latter are associated with poor clinical outcomes, but their functional status is not clear. The phosphorylation of the S6 ribosomal protein ...
Niwas Ram R Microbiology Division, CSIR-Central Drug Research Institute, Lucknow, - - 2014
Production of cholesterol oxidase (COD) under batch conditions through Ca-alginate immobilized cells of Streptomyces sp. was investigated. The process was studied for optimal immobilization conditions, beads operational stability and comparisons were made with the COD production via free cells. Influence of Na-alginate concentration (1-5 g L(-1) ) and initial biomass loading on ...
Fathy Mohamed Yasmine Y Centre for Infection and Immunity, Queen's University Belfast, Belfast, BT9 7AE, United - - 2014
The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not been characterized. However, the B. cenocepacia genome contains homologues of genes encoding PG biosynthetic functions in other bacteria. PG biosynthesis involves the formation of the undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-MurNAc-pentapeptide, known as lipid II, which is built ...
Uesato Shinichi S Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, - - 2014
Non-small-cell lung carcinomas do not sufficiently respond to cancer chemotherapeutic drugs. Combination effects of cancer chemotherapy drugs (paclitaxel and carboplatin) with nobiletin or powdered Shiikuwasha extract from Citrus depressa were examined by isobologram and combination index analyses. It was demonstrated that the combination generated a synergistic inhibitory effect against the ...
Kuzu Omer F OF Department of Pharmacology, The Pennsylvania State - - 2014
Leelamine is a promising compound for the treatment of cancer; however the molecular mechanisms leading to leelamine-mediated cell death have not been identified. This report shows that leelamine is a weakly basic amine with lysosomotropic properties leading to its accumulation inside acidic organelles such as lysosomes. This accumulation leads to ...
Yang Aizhen A Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou 215006, - - 2014
Phagocytosis of apoptotic cells (efferocytosis) is essential for regulation of immune responses and tissue homeostasis and is mediated by phagocytic receptors. In this study, we found that urokinase plasminogen activator receptor (uPAR) plays an important role in internalization of apoptotic cells and also characterized the underlying mechanisms. In a flow ...
Fumoto Seiko S Departments of Pediatrics - - 2014
No monochorionic dizygotic twins (MCDZTs) with cellular chimerism involving cells other than blood cells have been reported in the literature to date. Here we report a probable first case of MCDZTs with buccal cell chimerism. A 32-year-old woman conceived twins by in vitro fertilization by using 2 cryopreserved blastocysts that ...
Chen Xiaojiao - - 2014
We demonstrate a multivalent recognition and highly selective aptamer signal amplification strategy for electrochemical cytosensing and dynamic cell surface N-glycan expression evaluation by the combination of Con A, a mannose binding protein as model, conjugated poly(amidoamine) (PAMAM) dendrimer on chemically reduced graphene oxide (rGO-DEN) interface, and aptamer and horseradish peroxidase ...
Talbott Heather H H Talbott, Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, United - - 2014
Recent studies suggest that chemokines may mediate the luteolytic action of PGF2α (PGF). Our objective was to identify chemokines induced by PGF in vivo and to determine the effects of IL8 on specific luteal cell types in vitro. Midcycle cows were injected with saline or PGF, ovaries were removed after ...
Macvittie Kevin K Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. - - 2014
The electrochemical memristor based on a pH-switchable polymer-modified electrode integrated with a biofuel cell was designed and proposed for interfacing between biomolecular information processing and electronic systems. The present approach demonstrates a new application of biofuel cells in information processing systems, rather than for electrical power generation.
Czarny T L TL Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5 Canada; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, - - 2014
The emergence of antibiotic resistance in recent years has radically reduced the clinical efficacy of many antibacterial treatments and now poses a significant threat to public health. One of the earliest studied and well validated targets for antimicrobial discovery is the bacterial cell wall. The essential nature of this pathway, ...
Zhao Yan Y Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK Department of Anesthesiology, Peking University Third Hospital Beijing, - - 2014
Background: Neuroinflammation is a notable hallmark of Alzheimer's disease pathogenesis and can markedly exacerbate amyloid pathology. Celastrol, a pentacyclic-triterpene, has been found to possess anti-inflammatory properties. Objective: The purpose of this study was to characterize the effects of celastrol on cell viability and amyloid-β (Aβ) production induced by lipopolysaccharide (LPS) ...
Chandra S S Cornell SIMS Laboratory, Department of Biomedical Engineering, Cornell University, Ithaca, New York, - - 2014
Boron neutron capture therapy (BNCT) of cancer depends on the selective delivery of a sufficient number of boron-10 ((10) B) atoms to individual tumour cells. Cell killing results from the (10) B (n, α)(7) Li neutron capture and fission reactions that occur if a sufficient number of (10) B atoms ...
Mackay Craig C Authors' Affiliations: MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Science; Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School; and Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, United - - 2014
The genotoxin cisplatin is commonly used in chemotherapy to treat solid tumors, yet our understanding of the mechanism underlying the drug response is limited. In a focused siRNA screen, using an siRNA library targeting genes involved in ubiquitin and ubiquitin-like signaling, we identified the E3 ubiquitin ligase HOIP as a ...
Yang Bo B Department of Oncology - - 2014
Abstract Radioresistance is one of the main reasons for the failure of radiotherapy in laryngeal cancer. However, the mechanisms of radioresistance of tumor cells have remained elusive. This study was conducted to identify the ultrastructural changes of radiation-induced radioresistant laryngeal cancer hep-2 cell line. First, a radioresistant hep-2R cell line ...
Landreh Luise L Women's and Children's Health, Karolinska Institutet, Stockholm, - - 2014
Aim: We aim to examine the steroidogenic phenotype and the differentiation potential of human testicular peritubular cells (HTPC) and to explore their possible relationship to the adult Leydig cell lineage. Background: Cells of the adult Leydig cell lineage may reside in the peritubular compartment of the testis. This suggestion is ...
Haratifar Sanaz S Department of Food Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1. - - 2014
Numerous studies have demonstrated that tea catechins form complexes with milk proteins, especially caseins. Much less work has been conducted to understand the metabolic conversions of tea-milk complexes during gastro-duodenal digestion. The objective of this study was to determine the significance of this association on the digestibility of the milk ...
Yang Kezhen K Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun, Beijing 100093, - - 2014
The Arabidopsis stoma is a specialized epidermal valve made up of a pair of guard cells around a pore whose aperture controls gas exchange between the shoot and atmosphere. Guard cells (GCs) are produced by a symmetric division of guard mother cells (GMCs). The R2R3-MYB transcription factor FOUR LIPS (FLP) ...
Demirel Yaşar Y Department of Chemical and Biomolecular Engineering, University of Nebraska Lincoln, - - 2014
This commentary is on the concept used by Ding and Luo (2013) to measure the rate of entropy production in normal cell and cancerous cell lines under an alternating electric field.
Fang Zhiqing Z Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. - - 2014
Previous studies have demonstrated that metformin (Met) may reduce the risk of cancer development. In the present study, the anti‑cancer effects of Met in A498 cells were investigated. It was found that Met inhibited A498 cell proliferation in a time‑ and dose‑dependent manner, as well as induced the activation of AMP‑activated ...
Yang Guang - - 2014
Background and purpose: A number of recent patents related to 125I seed and osteopontin have been awarded. In this study, we developed a new in vitro model to study the radiobiological effects of 125I seeds on cancer cells. Methods: We placed 125I seeds in a cell culture plate with cells ...
Chen X - - 2014
The epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells plays a key role in proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR), which lead to the loss of vision. The Jagged/Notch pathway has been reported to be essential in EMT during embryonic development, fibrotic diseases and cancer metastasis. However, ...
Popa Ioana I Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, Bucharest 060031, - - 2014
The receptor for advanced glycation end products (RAGE) is involved in multiple stages of tumor development and malignization. To gain further knowledge on the RAGE role in tumor progression, we investigated the receptor expression profile and its subcellular localization in melanoma cells at different stages of malignancy. We found that ...
Wright Jill J 3601 4(th) St Rm 5C119, Department of Cell Biology and Biochemistry, Texas Tech University, Health Sciences Center, Lubbock, TX 79430, - - 2014
When is less more? A new study reveals that decreased mitochondrial gene expression and reduced lipid biosynthesis may actually increase cell growth.
Heller Evan E Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, - - 2014
While gastrulation movements offer mechanistic paradigms for how collective cellular movements shape developing embryos, far less is known about coordinated cellular movements that occur later in development. Studying eyelid closure, we explore a case where an epithelium locally reshapes, expands, and moves over another epithelium. Live imaging, gene targeting, and ...
Gao Ju J Department of Anesthesiology, Subei People's Hospital of Jiangsu Province, Clinical Medical School of Yangzhou - - 2014
We aim to investigate the effects of preconditioning of physiological cyclic stretch on the alveolar epithelial cell apoptosis induced by pathologically mechanical stretch and barrier dysfunction and how these effects are linked to differential expression of small GTPases Rac and Rho mRNA. Pulmonary alveolar epithelial cells were subjected to different ...
Bénit Paule P INSERM, UMR1141, Hôpital Robert Debré, 75019 Paris, France; U.F.R. de Médecine Université Paris Diderot, 75019 Paris, - - 2014
Seventy years from the formalization of the Krebs cycle as the central metabolic turntable sustaining the cell respiratory process, key functions of several of its intermediates, especially succinate, and fumarate, have been recently uncovered. The presumably immutable organization of the cycle has been challenged by a number of observations, and ...
Katou Yasuhiro Y Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8678, - - 2014
Metarhizin A was originally isolated from Metarhizium flavoviride as a potent inhibitor of the growth of insect and mammalian cells. In this study, we aimed to understand the molecular targets of metarhizin A involved in its anti-proliferative activity against human cells. Cell cycle regulators and signaling molecules were examined by ...
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