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Jones Laura A LA Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, - - 2014
Cytoplasmic dynein 1 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we have used small interfering RNAs or morpholino oligonucleotides to deplete ...
Chen Haifen H School of Computer Engineering, Nanyang Technological University, Singapore 639798, Genome Institute of Singapore, Biopolis, Singapore 138672, Singapore, School of Electronics and Computer Science, University of Southampton, Highfield, Southampton SO17 1BJ, - - 2014
Transcriptional regulatory networks controlling cell fate decisions in mammalian embryonic development remain elusive despite a long time of research. The recent emergence of single-cell RNA profiling technology raises hope for new discovery. Although experimental works have obtained intriguing insights into the mouse early development, a holistic and systematic view is ...
Zhu Bofan - - 2014
Biocomposite matrices with high mechanical strength, high stability and the ability to direct matrix-specific stem cell differentiation are essential for the reconstruction of lesioned tissues in tissue engineering and cell therapeutics. Toward this end, we used the electrospinning technique to fabricate well-aligned composite fibers from collagen and spider dragline silk ...
Liu Kuan-Yu KY Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, ROC Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan, - - 2014
Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the cytoplasm, nuclei, and axons of neurons is a hallmark of Huntington's disease (HD), although how these fragments negatively impact neurons remains unclear. We followed the distribution of mHTT in the striata of transgenic R6/2-J2 HD mice as their motor function ...
Richards Gemma Sian GS Sars Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, Bergen N-5008, - - 2014
Bilaterian neurogenesis is characterized by the generation of diverse neural cell types from dedicated neural stem/progenitor cells (NPCs). However, the evolutionary origin of NPCs is unclear, as neurogenesis in representatives of the bilaterian sister group, the Cnidaria, occurs via interstitial stem cells that also possess broader, non-neural, developmental potential. We ...
Lee Ji-Eun JE Department of Life Science and GT5 Program, Ewha Womans University, Seoul 120-750, - - 2014
The function of reactive oxygen species (ROS) as second messengers in cell differentiation has been demonstrated only for a limited number of cell types. Here, we used a wellestablished protocol for BMP2-induced neuronal differentiation of neural crest stem cells (NCSCs) to examine the function of BMP2-induced ROS during the process. ...
Ebrahimi-Barough Somayeh S Brain and Spinal Cord Injury Research Center (BASIR), Tehran University of Medical Sciences, Keshavarz Boulevard, Gharib Street, 6114185, Tehran, - - 2014
Human endometrium is a high-dynamic tissue that contains human endometrial stem cells (hEnSCs) which can be differentiated into a number of cell lineages. The differentiation of hEnSCs into many cell lineages such as osteoblast, adipocyte, and neural cells has been investigated previously. However, the differentiation of these stem cells into ...
Varga Csaba C Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United - - 2014
Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier) and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. Here we show that each of the three ...
Zhang Jian J Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA - - 2014
Microtubules are known to play an important role in cell polarity; however, the mechanism remains unclear. Using cells migrating persistently on micropatterned strips, we found that depolymerization of microtubules caused cells to change from persistent to oscillatory migration. Mathematical modeling in the context of a local-excitation-global-inhibition control mechanism indicated that ...
Mak Michael M Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Biomedical Engineering, Boston University, Boston, Massachusetts, United States of - - 2014
Dimensionality is a fundamental component that can have profound implications on the characteristics of physical systems. In cell biology, however, the majority of studies on cell physical properties, from rheology to force generation to migration, have been performed on 2D substrates, and it is not clear how a more realistic ...
Arancillo Marife M Baylor College of - - 2014
Purkinje cell activity is essential for controlling motor behavior. During motor behavior Purkinje cells fire two types of action potentials: simple spikes that are generated intrinsically, and complex spikes that are induced by climbing fiber inputs. And although the functions of these spikes are becoming clear, how they are established ...
Wu Shuang S Department of Biology, University of Pennsylvania, Philadelphia, PA 19104; - - 2014
Formation of specialized cells and tissues at defined times and in specific positions is essential for the development of multicellular organisms. Often this developmental precision is achieved through intercellular signaling networks, which establish patterns of differential gene expression and ultimately the specification of distinct cell fates. Here we address the ...
Li Wenyan - - 2014
Nanocoating of a single-cell with biocompatible materials creates a defined microenvironment for cell differentiation and proliferation as well as a model for studies in cell biology. In addition, the acidic enviroment in the tissue of stroke victims necessitates drug release upon pH stimuli. Here we report the encapsulation of single ...
Iyer-Biswas Srividya S James Franck Institute and Institute for Biophysical - - 2014
Uncovering the quantitative laws that govern the growth and division of single cells remains a major challenge. Using a unique combination of technologies that yields unprecedented statistical precision, we find that the sizes of individual Caulobacter crescentus cells increase exponentially in time. We also establish that they divide upon reaching ...
Salehinejad Parvin P Institute of Bioscience, University Putra Malaysia, Kuala Lumpur, - - 2014
Many neural disorders are characterized by the loss of one or several types of neural cells. Human umbilical cord-derived mesenchymal cells (hUCMs) are capable of differentiating into neuron, astroglia-like and oligodendrocyte cell types. However, a reliable means of inducing the selective differentiation of hUCMs into neural cells in vitro has ...
Kim Kyeongmi K Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New - - 2014
Neural crest is a population of multipotent progenitor cells that form at the border of neural and non-neural ectoderm in vertebrate embryos, and undergo epithelial-mesenchymal transition and migration. According to the traditional view, the neural crest is specified in early embryos by signaling molecules including BMP, FGF and Wnt proteins. ...
Lee Yi-Ying YY Department of Marine Biotechnology, University of Maryland Baltimore County, and Institute of Marine and Environmental Technology, 701 East Pratt Street, Baltimore, MD - - 2014
Proteus mirabilis is a dimorphic motile bacterium well-known for its flagella-dependent swarming motility over surfaces. In liquid, P. mirabilis cells are 1.5-2.0 μm swimmer cells with 4-6 flagella. When P. mirabilis encounters a solid surface, where flagellar rotation is limited, swimmer cells differentiate into elongated (10-80 μm), highly flagellated swarmer ...
You Jingwen J Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, - - 2014
Solute carrier family 2 (facilitated glucose/fructose transporter) member 5 (SLC2A5)-inhibited seven different molecular Pearson mutual-positive-correlation networks constructed by 24 overlapping molecules from 368 GRNInfer and 34 Pearson under SLC2A5 CC ≤-0.25 in low human normal adjacent tissues were compared with high lung adenocarcinoma. Based on GO, KEGG, GenMAPP, BioCarta, and ...
Wu Ning N Univ. Grenoble Alpes, iRTSV-BGE, 38000, Grenoble, France, - - 2014
Extensive efforts have been made to understand the molecular actors that control epithelial cell fate. Although pieces of information have been obtained from single-gene function investigations, the entire picture of the molecular mechanisms involved in the regulation of epithelial homeostasis is still mysterious. Growing data indicate that gene networks rather ...
Kazemimoghadam Mahdieh - - 2014
Abstract Differentiation of bone marrow mesenchymal stem cells (BMSCs) into neural cells has received significant attention in recent years. However, there is still no practical method to evaluate differentiation process non-invasively and practically. The cellular quality evaluation method is still limited to conventional techniques, which are based on extracting genes ...
McDonald Angela C H AC Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, - - 2014
Little is known about the gene regulatory networks (GRNs) distinguishing extraembryonic endoderm (ExEn) stem (XEN) cells from those that maintain the extensively characterized embryonic stem cell (ESC). An intriguing network candidate is Sox17, an essential transcription factor for XEN derivation and self-renewal. Here, we show that forced Sox17 expression drives ...
Etxaniz Usue U Tissue Engineering Laboratory, Bioengineering Area, Instituto Biodonostia, Hospital Universitario Donostia, Paseo Dr. Begiristain s/n, 20014 San Sebastián, - - 2014
Resident neural precursor cells (NPCs) have been reported for a number of adult tissues. Understanding their physiological function or, alternatively, their activation after tissue damage or in vitro manipulation remains an unsolved issue. Here, we investigated the source of human dermal NPCs in adult tissue. By following an unbiased, comprehensive approach ...
Meyer Zum Gottesberge A M AM Department of Otorhinolaryngology, Research Laboratory, Medical Faculty, Heinrich-Heine-University Düsseldorf, No. 23.12, Universitätsstr. 1, 40225, Düsseldorf, Germany, - - 2014
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor activated by native collagen. DDRs regulate cell adhesion, migration and various other cell functions. Deletion of the DDR1 gene in mice is associated with a severe decrease in auditory function and substantial structural alterations in a heterogeneous group of cells, ...
Zhang Shihua S National Center for Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, - - 2014
Neph et al. (2012) (Circuitry and dynamics of human transcription factor regulatory networks. Cell, 150: 1274-1286) reported the transcription factor (TF) regulatory networks of 41 human cell types using the DNaseI footprinting technique. This provides a valuable resource for uncovering regulation principles in different human cells. In this paper, the architectures ...
Zouani Omar F OF Univ. Bordeaux, Institut Européen de Chimie et Biologie, CNRS UMR 5248, F-33607 Pessac, France. - - 2014
The interior of the cell nucleus is comparable to a solid network bathed in an interstitial fluid. From the extrapolation of low frequency data, it is expected that such network should dictate the response of the nucleus to mechanical stress at high frequencies, described by unique elastic moduli. However, none ...
Katzenmaier Eva-Maria EM Pathologisches Institut, Abteilung Angewandte Tumorbiologie, Ruprecht-Karls-Universität, Heidelberg, - - 2014
The physiological compound sodium butyrate can induce differentiation in colon cancer cells in vitro. Due to the role of galectins in growth control we explored its effect on this network beyond galectins-1 and -3, with deliberate consideration of the status of microsatellite stability, for nine cell lines. Microscopical monitoring and ...
Cajal Marieke M Université Paris Diderot, Sorbonne Paris Cité, Institut Jacques Monod, UMR7592 CNRS, Paris F-75013, - - 2014
During the early steps of head development, ectodermal patterning leads to the emergence of distinct non-neural and neural progenitor cells. The induction of the preplacodal ectoderm and the neural crest depends on well-studied signalling interactions between the non-neural ectoderm fated to become epidermis and the prospective neural plate. By contrast, ...
Fritz Andrew J AJ Department of Biological Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of - - 2014
The interchromosomal organization of a subset of human chromosomes (#1, 4, 11, 12, 16, 17, and 18) was examined in G1 and S phase of human WI38 lung fibroblast and MCF10A breast epithelial cells. Radial positioning of the chromosome territories (CTs) was independent of gene density, but size dependent. While ...
Valente Sabrina S DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Clinical Pathology, University of Bologna , Bologna , Italy - - 2014
Abstract Cells use several mechanisms to transfer information to other cells. In this study, we describe micro/nanotubular connections and exosome-like tubule fragments in multipotent mesenchymal stem cells (MSCs) from human arteries. Scanning and transmission electron microscopy allowed characterization of sinusoidal microtubular projections (700 nm average size, 200 µm average length, with bulging ...
Scuffi Denise D IIB CONICET - - 2014
Abscisic acid (ABA) is a well-studied regulator of stomatal movement. Hydrogen sulfide (H2S), a small signaling gas molecule involved in key physiological processes in mammals, has been recently reported as a new component of ABA signaling network in stomatal guard cells. In Arabidopsis, H2S is enzymatically produced in the cytosol ...
Paradells Sara S Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avda Seminario, 46113, Moncada, Valencia, - - 2014
Ochratoxin A (OTA), a mycotoxin that was discovered as a secondary metabolite of the fungal species Aspergillus and Penicillium, is a common contaminant in food and animal feed. This mycotoxin has been described as teratogenic, carcinogenic, genotoxic, immunotoxic and has been proven a potent neurotoxin. Other authors have previously reported ...
Ezin Maxellende M Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United - - 2014
The anterior neural fold (ANF) is the only region of the neural tube that does not produce neural crest cells. Instead, ANF cells contribute to the olfactory and lens placodes, as well as to the forebrain and epidermis. Here, we test the ability of the ANF to form neural crest ...
Sassi Massimiliano M Laboratoire de Reproduction et Développement des Plantes, INRA, CNRS, ENS, UCB Lyon 1, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address: - - 2014
To control morphogenesis, molecular regulatory networks have to interfere with the mechanical properties of the individual cells of developing organs and tissues, but how this is achieved is not well known. We study this issue here in the shoot meristem of higher plants, a group of undifferentiated cells where complex ...
Zhang Ruiping R State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,Beijing 100101, - - 2014
Mesenchymal stem cells (MSCs) can differentiate into neural cells to treat nervous system diseases. Magnetic resonance is an ideal means for cell tracking through labeling cells with superparamagnetic iron oxide (SPIO). However, no studies have described the neural differentiation ability of SPIO-labeled MSCs, which is the foundation for cell therapy ...
Drumm Bernard T BT Department of Physiology &Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, - - 2014
Interstitial cells of Cajal (ICC) serve several critical physiological roles in visceral smooth muscle organs, including acting as electrical pacemakers to modulate phasic contractile activity and as intermediaries in motor neurotransmission. The major roles of ICC have been described in the gastrointestinal tract, however, ICC-like cells (ICC-LC) can also be ...
Zhang Dongcheng D Embryology Unit, Murdoch Childrens Research - - 2014
The neural crest is the name given to the strip of cells at the junction between neural and epidermal ectoderm in neurula-stage vertebrate embryos, which is later brought to the dorsal neural tube as the neural folds elevate. The neural crest is a heterogeneous and multipotent progenitor cell population whose ...
Noisa Parinya P Institute of Biomedicine/Physiology, University of Helsinki, Finland; School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, - - 2014
Neural crest cells are multipotent cells, which are specified in embryonic ectoderm in the border of neural plate and epiderm during early development by interconnection of extrinsic stimuli and intrinsic factors. Neural crest cells are capable of differentiating into various somatic cell types, including melanocytes, craniofacial cartilage and bone, smooth ...
Karunamuni Ganga H GH Department of Pediatrics, Case Western Reserve University School of Medicine, Case Medical Center Division of Pediatric Cardiology, Rainbow Babies and Children's Hospital, Cleveland, - - 2014
Neural crest cells play many key roles in embryonic development, as demonstrated by the abnormalities that result from their specific absence or dysfunction. Unfortunately, these key cells are particularly sensitive to abnormalities in various intrinsic and extrinsic factors, such as genetic deletions or ethanol-exposure that lead to morbidity and mortality ...
Badizadegan Kamran K Nemours Childrens - - 2014
The enteric nervous system (ENS) is composed of neural crest-derived neurons (also known as "ganglion cells") whose cell bodies are located in the submucosal and myenteric plexuses of the intestinal wall. Intramucosal ganglion cells are known to exist, but are rare and often considered ectopic. Also derived from the neural ...
Kilbride Peter P Institute of Liver and Digestive Health, Royal Free Hospital Campus, UCL, London, NW3 2PF, UK. Electronic address: - - 2014
The process of ice formation and propagation during cryopreservation impacts on the post-thaw outcome for a sample. Two processes, either network solidification or progressive solidification, can dominate the water-ice phase transition with network solidification typically present in small sample cryo-straws or cryo-vials. Progressive solidification is more often observed in larger ...
Jahani Hoda H Department of Stem Cell Biology, Stem Cell Technology Research Center, Tehran, IRAN; Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, - - 2014
Differentiation of mesenchymal stem cells (MSCs) into neuron cells has great potential in therapy of damaged nerve tissue. It has been shown that three dimensional (3D) biomaterials have great ability to up regulate the expression of neuronal proteins. In this study, O2 plasma technology was used to enhance hydrophilicity of ...
Liu Chao C Department of Histology and Embryology, Institute of Stem Cell and Tissue Engineering, Anhui Medical University, Hefei, Anhui 230032, China; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, CA 94143, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: - - 2014
Directed neural differentiation of human embryonic stem cells (ESCs) enables researchers to generate diverse neuronal populations for human neural development study and cell replacement therapy. To realize this potential, it is critical to precisely understand the role of various endogenous and exogenous factors involved in neural differentiation. Cell density, one ...
Bristow Sara L - - 2014
BackgroundThe coupling of cyclin dependent kinases (CDKs) to an intrinsically oscillating network of transcription factors has been proposed to control progression through the cell cycle in budding yeast, Saccharomyces cerevisiae. The transcription network regulates the temporal expression of many genes, including cyclins, and drives cell-cycle progression, in part, by generating ...
Palazuelos Javier J Department of Pharmacological Sciences, Centers for Molecular Medicine, Stony Brook University, SUNY, New York - - 2014
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination. Our study identifies ADAM17, also called tumor necrosis factor-α converting enzyme (TACE), as a novel key modulator of ...
Aghamaleky Sarvestany Arwin - - 2014
Low levels of survival of motor neuron (SMN) protein cause the neuromuscular disease spinal muscular atrophy (SMA), characterized by degeneration of lower motor neurons and atrophy of skeletal muscle. Recent work demonstrated that low levels of SMN also trigger pathological changes in Schwann cells, leading to abnormal axon myelination and ...
Nafea Eman H EH a Graduate School of Biomedical Engineering , University of New South Wales , Sydney 2052 , NSW , - - 2014
Incorporation of extracellular matrix (ECM) components to synthetic hydrogels has been shown to be the key for successful cell encapsulation devices, by providing a biofunctional microenvironment for the encapsulated cells. However, the influence of adding ECM components into synthetic hydrogels on the permeability as well as the physical and mechanical ...
Ogai Kazuhiro K Department of Molecular Neurobiology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan; Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 9200942, - - 2014
The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI ...
Yao Chih-Wei CW Division of Pulmonary and Critical Care Medicine and Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan Department of Respiratory Therapy, China Medical University, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine and Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan Department of Respiratory Therapy, China Medical University, Taichung, - - 2014
The purpose of this study was to assess the relationship of pleural-ADA (P-ADA) and non-Hodgkin's lymphoma (NHL). We retrospectively analyzed 63 NHL patients with pleural effusions who accepted a diagnostic thoracentesis, and who had P-ADA available at the China Medical University Hospital (Taichung, Taiwan) between January 2003 and April 2012. ...
Yu Robert K RK Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA, - - 2014
In mammals, the central and peripheral nervous systems are developmentally derived from cells in the neural plate. Specific ectodermal cells in this area form the neural tube and neural crest during the early developmental stage. The neural tube is the origin of the central nervous system which consists of both ...
Yazdankhah M M 1] IRCCS Fondazione Santa Lucia, Rome 00143, Italy [2] Department of Biology, University of Rome Tor Vergata, Rome 00133, - - 2014
Autophagy is a conserved proteolytic mechanism required for maintaining cellular homeostasis. The role of this process in vertebrate neural development is related to metabolic needs and stress responses, even though the importance of its progression has been observed in a number of circumstances, both in embryonic and in postnatal differentiating ...
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