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Jandzik David D 1] Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309, USA [2] Department of Zoology, Comenius University, Bratislava 84215, - - 2014
A defining feature of vertebrates (craniates) is a pronounced head that is supported and protected by a robust cellular endoskeleton. In the first vertebrates, this skeleton probably consisted of collagenous cellular cartilage, which forms the embryonic skeleton of all vertebrates and the adult skeleton of modern jawless and cartilaginous fish. ...
Zuhdi Nora N California State University Northridge, Biology Deptartment, MC 8303 18111 Nordhoff Street Northridge, CA 91330, - - 2014
Neural crest cells emerge from the dorsal neural tube early in development and give rise to sensory and sympathetic ganglia, adrenal cells, teeth, melanocytes and especially enteric nervous system. Several inhibitory molecules have been shown to play important roles in neural crest migration, among them are the chemorepulsive Slit1-3. It ...
Nelson Thomas J TJ Blanchette Rockefeller Neurosciences Institute, Morgantown, WV 26505 USA. Electronic address: - - 2014
Synaptogenesis plays a central role in associative learning and memory. The biochemical pathways that underlie synaptogenesis are complex and incompletely understood. Nevertheless, research has so far identified three conceptually distinct routes to synaptogenesis: cell-cell contact mediated by adhesion proteins, cell-cell biochemical signaling from astrocytes and other cells, and neuronal signaling ...
Hu Na N Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 - - 2014
Neural crest stem cells arise within the central nervous system but then undergo an epithelial-to-mesenchymal transition to migrate away and contribute to the peripheral nervous system and craniofacial skeleton. Here we show that DNA methyltransferase 3B (DNMT3B) is responsible for the loss of competence of dorsal neural tube cells to ...
Levin Michael M Biology Department, Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155-4243 - - 2014
In addition to biochemical gradients and transcriptional networks, cell behavior is regulated by endogenous bioelectrical cues originating in the activity of ion channels and pumps, operating in a wide variety of cell types. Instructive signals mediated by changes in resting potential control proliferation, differentiation, cell shape, and apoptosis of stem, ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pcbi.1003857.].
Munoz-Pinto Dany J DJ Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street Troy, NY, 12180, - - 2014
Collagen hydrogels have been widely investigated as scaffolds for vascular tissue engineering due in part to the capacity of collagen to promote robust cell adhesion and elongation. However, collagen hydrogels display relatively low stiffness and strength, are thrombogenic, and are highly susceptible to cell-mediated contraction. In the current work, we ...
Jones Laura A LA Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, - - 2014
Cytoplasmic dynein 1 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we have used small interfering RNAs or morpholino oligonucleotides to deplete ...
Chen Haifen H School of Computer Engineering, Nanyang Technological University, Singapore 639798, Genome Institute of Singapore, Biopolis, Singapore 138672, Singapore, School of Electronics and Computer Science, University of Southampton, Highfield, Southampton SO17 1BJ, - - 2014
Transcriptional regulatory networks controlling cell fate decisions in mammalian embryonic development remain elusive despite a long time of research. The recent emergence of single-cell RNA profiling technology raises hope for new discovery. Although experimental works have obtained intriguing insights into the mouse early development, a holistic and systematic view is ...
Zhu Bofan - - 2014
Biocomposite matrices with high mechanical strength, high stability and the ability to direct matrix-specific stem cell differentiation are essential for the reconstruction of lesioned tissues in tissue engineering and cell therapeutics. Toward this end, we used the electrospinning technique to fabricate well-aligned composite fibers from collagen and spider dragline silk ...
Liu Kuan-Yu KY Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, ROC Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan, - - 2014
Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the cytoplasm, nuclei, and axons of neurons is a hallmark of Huntington's disease (HD), although how these fragments negatively impact neurons remains unclear. We followed the distribution of mHTT in the striata of transgenic R6/2-J2 HD mice as their motor function ...
Richards Gemma Sian GS Sars Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, Bergen N-5008, - - 2014
Bilaterian neurogenesis is characterized by the generation of diverse neural cell types from dedicated neural stem/progenitor cells (NPCs). However, the evolutionary origin of NPCs is unclear, as neurogenesis in representatives of the bilaterian sister group, the Cnidaria, occurs via interstitial stem cells that also possess broader, non-neural, developmental potential. We ...
Lee Ji-Eun JE Department of Life Science and GT5 Program, Ewha Womans University, Seoul 120-750, - - 2014
The function of reactive oxygen species (ROS) as second messengers in cell differentiation has been demonstrated only for a limited number of cell types. Here, we used a wellestablished protocol for BMP2-induced neuronal differentiation of neural crest stem cells (NCSCs) to examine the function of BMP2-induced ROS during the process. ...
Ebrahimi-Barough Somayeh S Brain and Spinal Cord Injury Research Center (BASIR), Tehran University of Medical Sciences, Keshavarz Boulevard, Gharib Street, 6114185, Tehran, - - 2014
Human endometrium is a high-dynamic tissue that contains human endometrial stem cells (hEnSCs) which can be differentiated into a number of cell lineages. The differentiation of hEnSCs into many cell lineages such as osteoblast, adipocyte, and neural cells has been investigated previously. However, the differentiation of these stem cells into ...
Varga Csaba C Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United - - 2014
Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier) and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. Here we show that each of the three ...
Zhang Jian J Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA - - 2014
Microtubules are known to play an important role in cell polarity; however, the mechanism remains unclear. Using cells migrating persistently on micropatterned strips, we found that depolymerization of microtubules caused cells to change from persistent to oscillatory migration. Mathematical modeling in the context of a local-excitation-global-inhibition control mechanism indicated that ...
Mak Michael M Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Biomedical Engineering, Boston University, Boston, Massachusetts, United States of - - 2014
Dimensionality is a fundamental component that can have profound implications on the characteristics of physical systems. In cell biology, however, the majority of studies on cell physical properties, from rheology to force generation to migration, have been performed on 2D substrates, and it is not clear how a more realistic ...
Liu Ting T State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
Microtubule (MT)-dependent MT nucleation by γ-tubulin is required for interphase plant cells to establish a highly dynamic cortical MT network underneath the plasma membrane, which influences the deposition of cell wall materials and consequently governs patterns of directional cell expansion [1-6]. Newly formed MTs either assume 40° angles or are ...
Arancillo Marife M Baylor College of - - 2014
Purkinje cell activity is essential for controlling motor behavior. During motor behavior Purkinje cells fire two types of action potentials: simple spikes that are generated intrinsically, and complex spikes that are induced by climbing fiber inputs. And although the functions of these spikes are becoming clear, how they are established ...
Wu Shuang S Department of Biology, University of Pennsylvania, Philadelphia, PA 19104; - - 2014
Formation of specialized cells and tissues at defined times and in specific positions is essential for the development of multicellular organisms. Often this developmental precision is achieved through intercellular signaling networks, which establish patterns of differential gene expression and ultimately the specification of distinct cell fates. Here we address the ...
Li Wenyan - - 2014
Nanocoating of a single-cell with biocompatible materials creates a defined microenvironment for cell differentiation and proliferation as well as a model for studies in cell biology. In addition, the acidic enviroment in the tissue of stroke victims necessitates drug release upon pH stimuli. Here we report the encapsulation of single ...
Iyer-Biswas Srividya S James Franck Institute and Institute for Biophysical - - 2014
Uncovering the quantitative laws that govern the growth and division of single cells remains a major challenge. Using a unique combination of technologies that yields unprecedented statistical precision, we find that the sizes of individual Caulobacter crescentus cells increase exponentially in time. We also establish that they divide upon reaching ...
Salehinejad Parvin P Institute of Bioscience, University Putra Malaysia, Kuala Lumpur, - - 2014
Many neural disorders are characterized by the loss of one or several types of neural cells. Human umbilical cord-derived mesenchymal cells (hUCMs) are capable of differentiating into neuron, astroglia-like and oligodendrocyte cell types. However, a reliable means of inducing the selective differentiation of hUCMs into neural cells in vitro has ...
Kim Kyeongmi K Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New - - 2014
Neural crest is a population of multipotent progenitor cells that form at the border of neural and non-neural ectoderm in vertebrate embryos, and undergo epithelial-mesenchymal transition and migration. According to the traditional view, the neural crest is specified in early embryos by signaling molecules including BMP, FGF and Wnt proteins. ...
Rohn Jennifer L JL Centre for Clinical Science and Technology, Division of Medicine, University College London, Wolfson House, London NW1 2HE, UK. Electronic address: - - 2014
During animal cell division, an actin-based ring cleaves the cell into two. Problems with this process can cause chromosome missegregation and defects in cytoplasmic inheritance and the partitioning of organelles, which in turn are associated with human diseases [1-3]. Although much is known about how chromosome segregation is coupled to ...
Yin Haipeng H Key Laboratory for Tumor Immunology and Traditional Chinese Medicine Immunology, Key Laboratory for Rare and Uncommon Diseases, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, PR - - 2014
Complement regulatory proteins (CD55 and CD59) were known to be expressed in many tumors and tumor cell lines including colorectal carcinoma, and were proposed as immunotherapy targets, however whether knocking down of CD55 and CD59 will affect the sensitivity of HT-29 cells to chemotherapy drugs for example, 5-Fluorouracil and Oxaliplatin and ...
Bai Xiangzhi X Image Processing Center, Beijing University of Aeronautics and Astronautics, Beijing 100191, China. Electronic address: - - 2014
A shortest path-based algorithm is proposed in this paper to find splitting lines for touching cell nuclei. First, an initial splitting line is obtained through the distance transform of a marker image and the watershed algorithm. The initial splitting line is then separated into different line segments as necessary, and ...
Lee Yi-Ying YY Department of Marine Biotechnology, University of Maryland Baltimore County, and Institute of Marine and Environmental Technology, 701 East Pratt Street, Baltimore, MD - - 2014
Proteus mirabilis is a dimorphic motile bacterium well-known for its flagella-dependent swarming motility over surfaces. In liquid, P. mirabilis cells are 1.5-2.0 μm swimmer cells with 4-6 flagella. When P. mirabilis encounters a solid surface, where flagellar rotation is limited, swimmer cells differentiate into elongated (10-80 μm), highly flagellated swarmer ...
You Jingwen J Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, - - 2014
Solute carrier family 2 (facilitated glucose/fructose transporter) member 5 (SLC2A5)-inhibited seven different molecular Pearson mutual-positive-correlation networks constructed by 24 overlapping molecules from 368 GRNInfer and 34 Pearson under SLC2A5 CC ≤-0.25 in low human normal adjacent tissues were compared with high lung adenocarcinoma. Based on GO, KEGG, GenMAPP, BioCarta, and ...
Wu Ning N Univ. Grenoble Alpes, iRTSV-BGE, 38000, Grenoble, France, - - 2014
Extensive efforts have been made to understand the molecular actors that control epithelial cell fate. Although pieces of information have been obtained from single-gene function investigations, the entire picture of the molecular mechanisms involved in the regulation of epithelial homeostasis is still mysterious. Growing data indicate that gene networks rather ...
Kazemimoghadam Mahdieh - - 2014
Abstract Differentiation of bone marrow mesenchymal stem cells (BMSCs) into neural cells has received significant attention in recent years. However, there is still no practical method to evaluate differentiation process non-invasively and practically. The cellular quality evaluation method is still limited to conventional techniques, which are based on extracting genes ...
McDonald Angela C H AC Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, - - 2014
Little is known about the gene regulatory networks (GRNs) distinguishing extraembryonic endoderm (ExEn) stem (XEN) cells from those that maintain the extensively characterized embryonic stem cell (ESC). An intriguing network candidate is Sox17, an essential transcription factor for XEN derivation and self-renewal. Here, we show that forced Sox17 expression drives ...
Etxaniz Usue U Tissue Engineering Laboratory, Bioengineering Area, Instituto Biodonostia, Hospital Universitario Donostia, Paseo Dr. Begiristain s/n, 20014 San Sebastián, - - 2014
Resident neural precursor cells (NPCs) have been reported for a number of adult tissues. Understanding their physiological function or, alternatively, their activation after tissue damage or in vitro manipulation remains an unsolved issue. Here, we investigated the source of human dermal NPCs in adult tissue. By following an unbiased, comprehensive approach ...
Meyer Zum Gottesberge A M AM Department of Otorhinolaryngology, Research Laboratory, Medical Faculty, Heinrich-Heine-University Düsseldorf, No. 23.12, Universitätsstr. 1, 40225, Düsseldorf, Germany, - - 2014
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor activated by native collagen. DDRs regulate cell adhesion, migration and various other cell functions. Deletion of the DDR1 gene in mice is associated with a severe decrease in auditory function and substantial structural alterations in a heterogeneous group of cells, ...
Zhang Shihua S National Center for Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, - - 2014
Neph et al. (2012) (Circuitry and dynamics of human transcription factor regulatory networks. Cell, 150: 1274-1286) reported the transcription factor (TF) regulatory networks of 41 human cell types using the DNaseI footprinting technique. This provides a valuable resource for uncovering regulation principles in different human cells. In this paper, the architectures ...
Zouani Omar F OF Univ. Bordeaux, Institut Européen de Chimie et Biologie, CNRS UMR 5248, F-33607 Pessac, France. - - 2014
The interior of the cell nucleus is comparable to a solid network bathed in an interstitial fluid. From the extrapolation of low frequency data, it is expected that such network should dictate the response of the nucleus to mechanical stress at high frequencies, described by unique elastic moduli. However, none ...
Katzenmaier Eva-Maria EM Pathologisches Institut, Abteilung Angewandte Tumorbiologie, Ruprecht-Karls-Universität, Heidelberg, - - 2014
The physiological compound sodium butyrate can induce differentiation in colon cancer cells in vitro. Due to the role of galectins in growth control we explored its effect on this network beyond galectins-1 and -3, with deliberate consideration of the status of microsatellite stability, for nine cell lines. Microscopical monitoring and ...
Cajal Marieke M Université Paris Diderot, Sorbonne Paris Cité, Institut Jacques Monod, UMR7592 CNRS, Paris F-75013, - - 2014
During the early steps of head development, ectodermal patterning leads to the emergence of distinct non-neural and neural progenitor cells. The induction of the preplacodal ectoderm and the neural crest depends on well-studied signalling interactions between the non-neural ectoderm fated to become epidermis and the prospective neural plate. By contrast, ...
Fritz Andrew J AJ Department of Biological Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of - - 2014
The interchromosomal organization of a subset of human chromosomes (#1, 4, 11, 12, 16, 17, and 18) was examined in G1 and S phase of human WI38 lung fibroblast and MCF10A breast epithelial cells. Radial positioning of the chromosome territories (CTs) was independent of gene density, but size dependent. While ...
Valente Sabrina S DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Clinical Pathology, University of Bologna , Bologna , Italy - - 2014
Abstract Cells use several mechanisms to transfer information to other cells. In this study, we describe micro/nanotubular connections and exosome-like tubule fragments in multipotent mesenchymal stem cells (MSCs) from human arteries. Scanning and transmission electron microscopy allowed characterization of sinusoidal microtubular projections (700 nm average size, 200 µm average length, with bulging ...
Scuffi Denise D Instituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, 7600 Mar del Plata, Argentina (D.S., N.L., L.L., C.G.-M.); andInstituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Científicas y Universidad de Sevilla, 41092 Seville, Spain (C.Á., - - 2014
Abscisic acid (ABA) is a well-studied regulator of stomatal movement. Hydrogen sulfide (H2S), a small signaling gas molecule involved in key physiological processes in mammals, has been recently reported as a new component of the ABA signaling network in stomatal guard cells. In Arabidopsis (Arabidopsis thaliana), H2S is enzymatically produced ...
Paradells Sara S Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avda Seminario, 46113, Moncada, Valencia, - - 2014
Ochratoxin A (OTA), a mycotoxin that was discovered as a secondary metabolite of the fungal species Aspergillus and Penicillium, is a common contaminant in food and animal feed. This mycotoxin has been described as teratogenic, carcinogenic, genotoxic, immunotoxic and has been proven a potent neurotoxin. Other authors have previously reported ...
Ezin Maxellende M Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United - - 2014
The anterior neural fold (ANF) is the only region of the neural tube that does not produce neural crest cells. Instead, ANF cells contribute to the olfactory and lens placodes, as well as to the forebrain and epidermis. Here, we test the ability of the ANF to form neural crest ...
Sassi Massimiliano M Laboratoire de Reproduction et Développement des Plantes, INRA, CNRS, ENS, UCB Lyon 1, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address: - - 2014
To control morphogenesis, molecular regulatory networks have to interfere with the mechanical properties of the individual cells of developing organs and tissues, but how this is achieved is not well known. We study this issue here in the shoot meristem of higher plants, a group of undifferentiated cells where complex ...
Zhang Ruiping R State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,Beijing 100101, - - 2014
Mesenchymal stem cells (MSCs) can differentiate into neural cells to treat nervous system diseases. Magnetic resonance is an ideal means for cell tracking through labeling cells with superparamagnetic iron oxide (SPIO). However, no studies have described the neural differentiation ability of SPIO-labeled MSCs, which is the foundation for cell therapy ...
Drumm Bernard T BT Department of Physiology &Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, - - 2014
Interstitial cells of Cajal (ICC) serve several critical physiological roles in visceral smooth muscle organs, including acting as electrical pacemakers to modulate phasic contractile activity and as intermediaries in motor neurotransmission. The major roles of ICC have been described in the gastrointestinal tract, however, ICC-like cells (ICC-LC) can also be ...
Zhang Dongcheng D Embryology Unit, Murdoch Childrens Research - - 2014
The neural crest is the name given to the strip of cells at the junction between neural and epidermal ectoderm in neurula-stage vertebrate embryos, which is later brought to the dorsal neural tube as the neural folds elevate. The neural crest is a heterogeneous and multipotent progenitor cell population whose ...
Noisa Parinya P Institute of Biomedicine/Physiology, University of Helsinki, Finland; School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, - - 2014
Neural crest cells are multipotent cells, which are specified in embryonic ectoderm in the border of neural plate and epiderm during early development by interconnection of extrinsic stimuli and intrinsic factors. Neural crest cells are capable of differentiating into various somatic cell types, including melanocytes, craniofacial cartilage and bone, smooth ...
Karunamuni Ganga H GH Department of Pediatrics, Case Western Reserve University School of Medicine, Case Medical Center Division of Pediatric Cardiology, Rainbow Babies and Children's Hospital, Cleveland, - - 2014
Neural crest cells play many key roles in embryonic development, as demonstrated by the abnormalities that result from their specific absence or dysfunction. Unfortunately, these key cells are particularly sensitive to abnormalities in various intrinsic and extrinsic factors, such as genetic deletions or ethanol-exposure that lead to morbidity and mortality ...
Badizadegan Kamran K Nemours Childrens - - 2014
The enteric nervous system (ENS) is composed of neural crest-derived neurons (also known as "ganglion cells") whose cell bodies are located in the submucosal and myenteric plexuses of the intestinal wall. Intramucosal ganglion cells are known to exist, but are rare and often considered ectopic. Also derived from the neural ...
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