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Stower Matthew J MJ Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, - - 2014
The elaboration of anterior-posterior (A-P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epithelial cells, the anterior visceral endoderm (AVE). ...
Matsuo Isao I Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan - - 2014
During mouse embryogenesis, diffusible growth factors, i.e. fibroblast growth factors, Wnt, bone morphogenetic protein and Hedgehog family members, emanating from localized areas can travel through the extracellular space and reach their target cells to specify the cell fate and form tissue architectures in coordination. However, the mechanisms by which these ...
Vergara Daniele D Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, - - 2014
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Genes which have been implicated in autosomal-recessive PD include PARK2 which codes for parkin, an E3 ubiquitin ligase that participates in a variety of cellular activities. In this study, we compared parkin-mutant primary fibroblasts, from a patient with parkin ...
Hickman Graham J GJ The John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, NG11 8NS, UK; Biomolecular & Materials Interface Research Group, Nottingham Trent University, Nottingham, NG11 8NS, - - 2014
Developing materials that can preferentially select defined cancer cell populations for biological characterization will greatly enhance our understanding of cancer cell growth, differentiation, and invasion. The transitional events between epithelial and mesenchymal phenotypes are particularly crucial, as primary tumors and secondary metastasis are generally epithelial in nature, whereas circulating mesenchymal ...
Kramer Illan J IJ Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto, Ontario, M5S 3G4, Canada; IBM Canada Research & Development Centre, 120 Bloor Street East, Toronto, Ontario, M4W 1B7, - - 2014
A colloidal quantum dot solar cell is fabricated by spray coating under ambient conditions. By developing a room temperature spray coating technique and implementing a fully automated process with near monolayer control-an approach termed as sprayLD-an electronic defect is eliminated resulting in solar cell performance and statistical distribution superior to ...
Liu Yongmin Y Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, CCR, National Cancer Institute, NIH, Bldg. 37, Rm 4032, 37 Convent Drive, MSC-4255, Bethesda, MD, 20892-4255, USA, - - 2014
The nucleoside reverse transcriptase inhibitors (NRTIs), used for treatment of the human immunodeficiency virus-1, compromise mitochondria in cardiomyocytes and other host cells, limiting the clinical use of these drugs. To explore underlying mechanisms, we overexpressed PGC-1α, a master regulator of mitochondrial biogenesis, twofold in H9c2 rat cardiomyocyte cultures, hypothesizing that ...
de la Encarnación Ana A Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, - - 2014
Null mutations in GRN are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). However, the influence of progranulin (PGRN) deficiency in neurodegeneration is largely unknown. In neuroblastoma cells, silencing of GRN gene causes significantly reduced cell survival after serum withdrawal. The following observations suggest that alterations of the CDK4/6/retinoblastoma ...
Bonnemay Louise L Département de Chimie, Ecole Normale Supérieure - PSL Research University, UMR 8640 - CNRS - ENS - UPMC, Paris, - - 2014
Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the toolbox currently available in cell biology. Among the increasing ...
Kuilman Thomas T Chromosome Segregation Laboratory, Cancer Research UK London Research Institute Lincoln's Inn Fields Laboratories, London, UK t.kuilman@nki.nl - - 2014
The final event of the eukaryotic cell cycle is cytokinesis, when two new daughter cells are born. How the timing and execution of cytokinesis is controlled is poorly understood. Here, we show that downregulation of cyclin-dependent kinase (Cdk) activity, together with upregulation of its counteracting phosphatase Cdc14, controls each of ...
Mullineaux Conrad W CW School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, U.K.; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, - - 2014
Filamentous heterocyst-forming cyanobacteria are a beautiful example of prokaryotic multicellularity. The filaments can achieve simultaneous nitrogen fixation and oxygenic photosynthesis by co-operation between two cell types: the photosynthetic vegetative cells and the nitrogen-fixing heterocysts. The multicellular features exhibited by the system include differentiation of different cell types, metabolic interdependence and ...
Shi Runlin R Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, - - 2014
microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasis. On the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumor suppressors or oncogenes that target many cancer-related genes. This study aimed to investigate ...
Zhang Ting T Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu 610041, - - 2014
Recently, emerging evidence has shown that Stat3 controls tumor cell migration and invasion. However, the molecular mechanisms by which Stat3 controls the cell movement remain largely unknown. Embryonic gastrula progenitors display coordinated and orientated migration, called collective cell migration. Collective cell migration is the simultaneous movement of multiple cells and ...
Cardoso Henrique J HJ CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Covilhã, - - 2014
Maintaining the delicate balance between cell survival and death is of the utmost importance for the proper development of germ cells and subsequent fertility. On the other hand, the fine regulation of tissue homeostasis by mechanisms that control cell fate is a factor that can prevent carcinogenesis. c-KIT is a ...
Cerchiari Alec A UC Berkeley - UCSF, Bioengineering , Genentech Hall-N544, 600 16TH Street , San Francisco, California, United States, 94158 , 6174178212 ; - - 2014
Patterned 3D cell culture models aim to more accurately represent the in vivo architecture of a tissue for the purposes of testing drugs, studying multicellular biology, or engineering functional tissues. However, patterning 3D multicellular structures within very soft hydrogels (< 500 Pa) that mimic the physicochemical environment of many tissues ...
Cannet Aude A *Signaling and cytoskeleton dynamics group, CRBM-CNRS, University of Montpellier, 1919 route de Mende, 34293 Montpellier - - 2014
The Rho GTPases RhoA and Rac1 function as master regulators of cytokinesis by controlling the actomyosin cytoskeleton. RhoA and Rac1 have to be respectively activated and inactivated at the division plane for cytokinesis to occur properly. The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP. However, the ...
Graml Veronika V The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Genetics Department, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK; Institute of Biochemistry, ETH Zürich, Schafmattstrasse 18, HPM G16.2, Zürich 8093, - - 2014
Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to simultaneously survey the fission yeast genome with respect to three key cellular processes: ...
Davis George E GE Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: - - 2014
Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.
Miyako Eijiro E Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba 305-8565 (Japan). - - 2014
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that ...
Durdu Sevi S European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, - - 2014
Morphogenesis is the process whereby cell collectives are shaped into differentiated tissues and organs. The self-organizing nature of morphogenesis has been recently demonstrated by studies showing that stem cells in three-dimensional culture can generate complex organoids, such as mini-guts, optic-cups and even mini-brains. To achieve this, cell collectives must regulate ...
Tulin Frej F The Rockefeller University, New York, New York - - 2014
Research in yeast and animals has resulted in a well-supported consensus model for eukaryotic cell cycle control. The fit of this model to early diverging eukaryotes, such as the plant kingdom, remains unclear. Using the green alga Chlamydomonas reinhardtii, we developed an efficient pipeline, incorporating robotics, semiautomated image analysis, and ...
Hennig Stefan S Institut für Genetik, Technische Universität Dresden, 01062, Dresden, Germany, - - 2014
We report on a pheromone-based inter-species communication system, allowing for a controlled cell-cell communication between the two species Saccharomyces cerevisiae and Schizosaccharomyces pombe as a proof of principle. It exploits the mating response pathways of the two yeast species employing the pheromones, α- or P-factor, as signaling molecules. The authentic ...
Zeng Yuze - - 2014
We have designed and fabricated a nanocomposite substrate that can deliver spatially and temporally defined mechanical forces onto cells. This nanocomposite substrate comprises a 1.5 mm-thick near infrared (NIR) mechanoresponsive bottom layer of few-walled carbon nanotubes (FWCNTs) that are uniformly distributed and covalently connected to thermally responsive poly(N-isopropylacrylamide), and an ...
Lee Mihyun M Department of Chemistry, Center for Nature-inspired Technology in KINC, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of - - 2014
An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called "spheroform" inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet ...
Santra Tuhin Subhra TS Institute of Nano Engineering and Microsystems, National Tsing Hua University, Taiwan. - - 2014
We introduce a localized single-cell membrane nano-electroporation with controllable sequential molecular delivery by millisecond to nanosecond electrical pulses. An intense electrical field was generated by a pair of transparent indium tin oxide (ITO)-based nano-electrodes, which was confined to a narrow region of the single-cell membrane surface near the nano-electrode edges ...
Mentink Remco A RA Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the - - 2014
Members of the Wnt family of secreted signaling proteins are key regulators of cell migration and axon guidance. In the nematode C. elegans, the migration of the QR neuroblast descendants requires multiple Wnt ligands and receptors. We found that the migration of the QR descendants is divided into three sequential phases ...
Keire Paul A PA Benaroya Research Institute, United - - 2014
Leiomyosarcoma (LMS) is a mesenchymal cancer that occurs throughout the body. Although LMS is easily recognized histopathologically, the cause of the disease remains unknown. Versican, an extracellular matrix (ECM) proteoglycan, increases in LMS. Microarray analyses of 80 LMS and 24 leiomyomas show a significant elevated expression of versican in human ...
Su Boxing B Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, - - 2014
High Mobility Group N (HMGN) proteins are a family of chromatin structural proteins that specifically bind to nucleosome core particles. HMGN5 is a novel and characteristic member of the HMGN protein family. We have previously found that HMGN5 is upregulated in prostate cancer and its downregulation had been demonstrated to ...
Wang Ji - - 2014
Extracellular matrix (ECM) is a fibrous natural cell environment, possessing complicated micro-and nano- architectures, which provide extracellular signaling cues and influence cell behaviors. Mimicking this three dimensional micro environment in vitro is a challenge in developmental and disease biology. Here, suspended multilayer hierarchical nanofiber assemblies (diameter from microns to less ...
Aparicio Ricardo R Centro de Biología Molecular "Severo Ochoa" CSIC-UAM., c)NicolásCabrera1, 28049, Madrid, - - 2014
Background: The control of organ growth is critical for correct animal development. From flies to mammals the mechanisms regulating growth are conserved and the role of microRNAs in this process is emerging. The conserved miR-7 has been described to control several aspects of development. Results: Here, we have analyzed the ...
Kurup Samarchith P SP Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, - - 2014
During invasion of host cells by Trypanosoma cruzi, the parasite that causes Chagas disease, the elongated, flagellated trypomastigotes remodel into oval amastigotes with no external flagellum. The underlying mechanism of this remodeling and the fate of the flagellum are obscure. We discovered that T. cruzi trypomastigotes discard their flagella via an ...
Nijhout H Frederik HF Department of Biology, Duke University, Durham, NC 27708; email: - - 2014
The developmental mechanisms that control body size and the relative sizes of body parts are today best understood in insects. Size is controlled by the mechanisms that cause growth to stop when a size characteristic of the species has been achieved. This requires the mechanisms to assess size and respond ...
Zuo Yan Y University of Texas Health Science Center at Houston, Department of Integrative Biology and Pharmacology, 6431 Fannin St., Houston, Texas - - 2014
Animal cell division is a fundamental process that requires complex changes in cytoskeletal organization and function. Aberrant cell division often has disastrous consequences for the cell and can lead to cell senescence, neoplastic transformation or death. As important regulators of the actin cytoskeleton, Rho GTPases play major roles in regulating ...
Le Pabic Pierre P Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of - - 2014
Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical cadherin, Fat3, and its partner Dachsous-2 (Dchs2), control polarized cell-cell intercalation of cartilage precursors during craniofacial development. ...
Pigatti Fernanda Mombrini FM Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, SP, - - 2014
Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause. Malignant transformation in OLP lesions may be favored by changes in the expression of proteins that regulate cell proliferation and apoptosis. This study aimed to investigate these issues by immunohistochemical staining for Bcl-2 and Ki-67 and by correlating ...
Higuchi-Sanabria Ryo R Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, New York, NY, - - 2014
Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported to and/or enriched in the bud. Here, ...
Borawska Maria H MH a Department of Bromatology , Medical University of Bialystok , Bialystok , - - 2014
In the present study, we investigated the influence of extracts from Salix spp. honey (ESH), beebread (EBB), and royal jelly (ERJ) with and without temozolomide (TMZ) on cell lines derived from a patient with diffuse astrocytoma (DASC), human glioblastoma multiforme (U87MG), and normal human astroglia (SVGp12). DASC was identified by ...
Kim YongTae Y Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA - - 2014
Spatiotemporal regulation of cell contractility coordinates cell shape change to construct tissue architecture and ultimately directs the morphology and function of the organism. Here we show that contractility responses to spatially and temporally controlled chemical stimuli depend much more strongly on intercellular mechanical connections than on biochemical cues in both ...
Wang Ming M Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China; University of Chinese Academy of Sciences, Beijing, 100049, - - 2014
In Arabidopsis, stomata development initiates after protodermal cells acquire stomatal lineage cell fate. Stomata or their precursors communicate with their neighbor epidermal cells to ensure the "one cell spacing" rule. The signals from EPF/EPFL peptide ligands received by TOO MANY MOUTHS (TMM) and ERECTA-family receptors are supposed to be transduced ...
Benito-Gonzalez Ana A Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, and Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland - - 2014
Mechano-sensory hair cells (HCs), housed in the inner ear cochlea, are critical for the perception of sound. In the mammalian cochlea, differentiation of HCs occurs in a striking basal-to-apical and medial-to-lateral gradient, which is thought to ensure correct patterning and proper function of the auditory sensory epithelium. Recent studies have ...
Su Liyan L Université de Toulouse, INP-ENSA Toulouse, UMR990 Génomique et Biotechnologie des Fruits, Avenue de l'Agrobiopole, CS 32607, F-31326 Castanet-Tolosan, France. INRA, UMR990 Génomique et Biotechnologie des Fruits, 24 Chemin de Borde Rouge, CS 52627, F-31326 Castanet-Tolosan, - - 2014
Auxin is known to regulate cell division and cell elongation, thus controlling plant growth and development. Part of the auxin signaling pathway depends on the fine tuned degradation of the Aux/IAA transcriptional repressors. Recent evidence indicates that Aux/IAA proteins play a role in fruit development in tomato (Solanum lycopersicum Mill.), ...
Wu Lele L The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, PR China. Contributed equally to this - - 2014
The eukaryotic cell cycle is controlled by a complex regulatory network, which is still poorly understood. Here we demonstrate that TRPS1, an atypical GATA factor, modulates cell proliferation and controls cell cycle progression. Silencing TRPS1 had a differential effect on the expression of nine key cell cycle-related genes. Eight of ...
Terry Natalie A NA Children's Hospital of Philadelphia - - 2014
Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of enteroendocrine cells is a known cause of severe congenital diarrhea. Further, enteroendocrine cells regulate glucose metabolism, with the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), playing critical roles ...
Rolland Yannève Y IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, - - 2014
The role of endocytic proteins and the molecular mechanisms underlying epithelial cell cohesion and tumor dissemination are not well understood. Here, we report that the endocytic F-BAR-containing CDC42-interacting protein 4 (CIP4) is required for ERBB2- and TGF-β1-induced cell scattering, breast cancer (BC) cell motility and invasion into 3D matrices, and ...
Macara Ian G IG Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: - - 2014
Epithelia form intelligent, dynamic barriers between the external environment and an organism's interior. Intercellular cadherin-based adhesions adapt and respond to mechanical forces and cell density, while tight junctions flexibly control diffusion both within the plasma membrane and between adjacent cells. Epithelial integrity and homeostasis are of central importance to survival, ...
Chen Xing Judy XJ Cell Motility Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, - - 2014
Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the Ena/VASP EVH1 domain with an extended proline rich motif in ...
Mallem Muralidhar M GlycoFi, Biologics Discovery, Merck & Co., Inc., Lebanon, New Hampshire, - - 2014
Human serum albumin (HSA) is a cysteine rich molecule that is most abundant in human blood plasma. To remain viable in the market due to lower marketing costs for HSA, it is important to produce a large quantity in an economical manner by recombinant technology. The objective of this study ...
Chung Cheng-Ho CH Sanford-Burnham Medical Research Institute, La Jolla, - - 2014
The maternal embryonic leucine zipper kinase (MELK) is expressed in stem/progenitor cells in some adult tissues, where it has been implicated in diverse biological processes, including the control of cell proliferation. Here, we described studies on its role in adult pancreatic regeneration in response to injury induced by duct ligation ...
Zhang Rui - - 2014
BackgroundmiRNAs are involved in coordinating a variety of cellular processes by regulating their target genes. Aberrant expression of miRNAs is correlated with various cancers. Previous studies have shown that miR-337 is significantly down-regulated in pancreatic ductal adenocarcinoma (PDAC) and that its expression is negatively correlated to the expression of HOXB7. ...
Heise Nicole N Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, and Department of Microbiology and Immunology, Columbia University, New York, NY - - 2014
Germinal centers (GCs) are the sites where memory B cells and plasma cells producing high-affinity antibodies are generated during T cell-dependent immune responses. The molecular control of GC B cell maintenance and differentiation remains incompletely understood. Activation of the NF-κB signaling pathway has been implicated; however, the distinct roles of ...
Fernandez Jessie J Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, - - 2014
The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through the rice cuticle and into the underlying epidermal cells, where the fungus grows for the ...
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