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Benito-Gonzalez Ana A Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, and Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland - - 2014
Mechano-sensory hair cells (HCs), housed in the inner ear cochlea, are critical for the perception of sound. In the mammalian cochlea, differentiation of HCs occurs in a striking basal-to-apical and medial-to-lateral gradient, which is thought to ensure correct patterning and proper function of the auditory sensory epithelium. Recent studies have ...
Su Liyan L Université de Toulouse, INP-ENSA Toulouse, UMR990 Génomique et Biotechnologie des Fruits, Avenue de l'Agrobiopole, CS 32607, F-31326 Castanet-Tolosan, France. INRA, UMR990 Génomique et Biotechnologie des Fruits, 24 Chemin de Borde Rouge, CS 52627, F-31326 Castanet-Tolosan, - - 2014
Auxin is known to regulate cell division and cell elongation, thus controlling plant growth and development. Part of the auxin signaling pathway depends on the fine tuned degradation of the Aux/IAA transcriptional repressors. Recent evidence indicates that Aux/IAA proteins play a role in fruit development in tomato (Solanum lycopersicum Mill.), ...
Terry Natalie A NA Children's Hospital of Philadelphia - - 2014
Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of enteroendocrine cells is a known cause of severe congenital diarrhea. Further, enteroendocrine cells regulate glucose metabolism, with the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), playing critical roles ...
Chen Xing Judy XJ Cell Motility Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, - - 2014
Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the Ena/VASP EVH1 domain with an extended proline rich motif in ...
Rolland Yannève Y IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, - - 2014
The role of endocytic proteins and the molecular mechanisms underlying epithelial cell cohesion and tumor dissemination are not well understood. Here, we report that the endocytic F-BAR-containing CDC42-interacting protein 4 (CIP4) is required for ERBB2- and TGF-β1-induced cell scattering, breast cancer (BC) cell motility and invasion into 3D matrices, and ...
Macara Ian G IG Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: - - 2014
Epithelia form intelligent, dynamic barriers between the external environment and an organism's interior. Intercellular cadherin-based adhesions adapt and respond to mechanical forces and cell density, while tight junctions flexibly control diffusion both within the plasma membrane and between adjacent cells. Epithelial integrity and homeostasis are of central importance to survival, ...
Mallem Muralidhar M GlycoFi, Biologics Discovery, Merck & Co., Inc., Lebanon, New Hampshire, - - 2014
Human serum albumin (HSA) is a cysteine rich molecule that is most abundant in human blood plasma. To remain viable in the market due to lower marketing costs for HSA, it is important to produce a large quantity in an economical manner by recombinant technology. The objective of this study ...
Chung Cheng-Ho CH Sanford-Burnham Medical Research Institute, La Jolla, - - 2014
The maternal embryonic leucine zipper kinase (MELK) is expressed in stem/progenitor cells in some adult tissues, where it has been implicated in diverse biological processes, including the control of cell proliferation. Here, we described studies on its role in adult pancreatic regeneration in response to injury induced by duct ligation ...
Zhang Rui - - 2014
BackgroundmiRNAs are involved in coordinating a variety of cellular processes by regulating their target genes. Aberrant expression of miRNAs is correlated with various cancers. Previous studies have shown that miR-337 is significantly down-regulated in pancreatic ductal adenocarcinoma (PDAC) and that its expression is negatively correlated to the expression of HOXB7. ...
Heise Nicole N Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, and Department of Microbiology and Immunology, Columbia University, New York, NY - - 2014
Germinal centers (GCs) are the sites where memory B cells and plasma cells producing high-affinity antibodies are generated during T cell-dependent immune responses. The molecular control of GC B cell maintenance and differentiation remains incompletely understood. Activation of the NF-κB signaling pathway has been implicated; however, the distinct roles of ...
Fernandez Jessie J Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, - - 2014
The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through the rice cuticle and into the underlying epidermal cells, where the fungus grows for the ...
Chen Zaixing Z - - 2014
Epithelial sodium channels (ENaC) govern transepithelial salt and fluid homeostasis. ENaC contributes to polarization, apoptosis, epithelial-mesenchymal transformation etc. Fibrinolytic proteases play a crucial role in virtually all of these processes and are elaborated by the airway epithelium. We hypothesized that urokinase-like plasminogen activator (uPA) regulates ENaC function in airway epithelial ...
Youk Hyun H Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, - - 2014
Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.
Giarola Naira Lígia Lima NL Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Brazil - UFRJ; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Brazil - - - 2014
Leishmania amazonensis is a protozoan parasite that induces mucocutaneous and diffuse cutaneous lesions upon infection. An important component in treatment failure is the emergence of drug-resistant parasites. It is necessary to clarify the mechanism of resistance that occurs in these parasites to develop effective drugs for leishmaniasis treatment. Promastigote forms ...
El Zawily Amr M AM University of - - 2014
Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically and dynamically from those in other eukaryotes. FRIENDLY, a member of the clu-superfamily, is conserved amongst eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY ...
Fernandez S S CNR Institute of Genetics and Biophysics, Naples, - - 2014
MicroRNAs (miRNAs) control cell cycle progression by targeting the transcripts encoding for cyclins, CDKs and CDK inhibitors, such as p27(KIP1) (p27). p27 expression is controlled by multiple transcriptional and posttranscriptional mechanisms, including translational inhibition by miR-221/222 and posttranslational regulation by the SCF(SKP2) complex. The oncosuppressor activity of miR-340 has been ...
Alvarez-Torres Daniel D Universidad de Málaga, Departamento de Genética, Facultad de Ciencias, 29071 Málaga, Spain; Universidad de Málaga, Departamento de Microbiología, Facultad de Ciencias, 29071 Málaga, - - 2014
Mx proteins are main effectors of the antiviral innate immune defence mediated by type I interferon (IFN I). The IFN I response is under a complex regulation; hence, one of the key issues in understanding virus-host interaction is the knowledge of the regulatory mechanisms governing this response. With this purpose, ...
Steinmann Vera V Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, - - 2014
Tin sulfide (SnS) as a promising absorber material in thin-film photovoltaic devices is described. Here, we confirm that SnS evaporates congruently, which provides facile composition control akin to cadmium telluride. We demonstrate a SnS heterojunction solar cell with a power conversion efficiency of 3.88% (certified), and we present an empirical ...
Derikvand Peyman P Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, IR - - 2014
Sulfur oxides released from the burning of oil causes severe environmental pollution. The sulfur can be removed via the 4S pathway in biodesulfurization (BDS). Immobilization approaches have been developed to prevent cell contamination of oil during the BDS process. The encapsulation of Rhodococcus erythropolis R1 in calcium alginate beads was ...
Zhou Weizhi W School of Environmental Science and Engineering, Shandong University, Jinan 250100, Shandong, China; State Key Lab of Microbial Technology, Shandong University, Jinan 250100, Shandong, China. Electronic address: - - 2014
Comparison of the bioremoval and recovery of Cd(II) by growing and grown marine bacterium Pseudoalteromonas sp. SCSE709-6 was performed in batch systems. Bioremoval with growing cells (Sorption I) showed better performance at low Cd(II) concentrations, whereas bioremoval with grown cells (Sorption II) had significant advantages in both removal efficiency and ...
Fu Xiao-Hong XH The State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, - - 2014
In telomerase negative yeast cells, Rad52-dependent recombination is activated to maintain telomeres. This recombination-mediated telomere elongation usually involves two independent pathways, type I and type II, and leads to generation of type I and type II survivors. It remains elusive whether the recombination-mediated telomere elongation prefers to take place on ...
Barthes Julien J Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1121, "Biomatériaux et Bioingénierie", 11 rue Humann, 67085 Strasbourg Cedex, - - 2014
In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells' behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional ...
Bandeira Carla Letícia CL Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, No. 1524, Cidade Universitária, 05508-900 São Paulo, SP, - - 2014
CRIPTO-(CR)1 is a protein associated with tumorigenesis and metastasis. Here we demonstrate that CR-1 expression in normal and creta placentas is associated with various degrees of uterine invasion. Cytokeratin (CK) and CR-1 protein expression was visualized by immunohistochemical staining of formalin-fixed, paraffin-embedded placental specimens (control placentas, n = 9; accreta, ...
Dong Peng P Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina 27708, - - 2014
A body of evidence has shown that the control of E2F transcription factor activity is critical for determining cell cycle entry and cell proliferation. However, an understanding of the precise determinants of this control, including the role of other cell-cycle regulatory activities, has not been clearly defined. Here, recognizing that ...
Rihan F A FA Department of Mathematical Sciences, College of Science, UAE University, P.O. Box 15551, Al-Ain, UAE ; Department of Mathematics, Faculty of Science, Helwan University, Cairo 11795, - - 2014
We present a delay differential model with optimal control that describes the interactions of the tumour cells and immune response cells with external therapy. The intracellular delay is incorporated into the model to justify the time required to stimulate the effector cells. The optimal control variables are incorporated to identify ...
Luo Wei W 1] Department of Chemistry, Carolina Center for Genome Science, Carolina Center for Cancer Nanotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [2] Department of Chemistry and Biology, Centre for Research in Biomolecular Interactions, York University, Toronto, Ontario, M3J 1P3, - - 2014
We report a general cell surface molecular engineering strategy via liposome fusion delivery to create a dual photo-active and bio-orthogonal cell surface for remote controlled spatial and temporal manipulation of microtissue assembly and disassembly. Cell surface tailoring of chemoselective functional groups was achieved by a liposome fusion delivery method and ...
Stathopoulou Athanasia A Department of Cancer Biology, University College London Cancer Institute, London, United - - 2014
The agouti viable (Avy) locus is considered a model to understand how retroelements function as controlling elements in mammals. Epigenetic factors, principally CpG methylation, are widely held to play a dominant regulatory role in controlling the locus' activity. The purpose of this study was to examine its behavior in ES ...
Ikeda Miho M Division of Strategic Research and Development, Graduate School of Science and Engineering, Satitama University Saitama, - - 2014
In contrast to somatic mammalian cells, which cannot alter their fate, plant cells can dedifferentiate to form totipotent callus cells and regenerate a whole plant, following treatment with specific phytohormones. However, the regulatory mechanisms and key factors that control differentiation-dedifferentiation and cell totipotency have not been completely clarified in plants. ...
Green Samantha E - - 2013
Cobalt(II) and nickel(II) ions display similar chemical properties and act as hypoxia mimics in cells. However, only soluble Co(II) but not soluble Ni(II) is carcinogenic by inhalation. To explore potential reasons for these differences, we examined responses of human lung cells to both metals. We found that Co(II) showed almost ...
Abbott Rosalyn D RD School of Engineering, University of Vermont, Burlington, VT, - - 2013
Cells isolated from moderately and severely degenerated human intervertebral disks (IVDs) cultured in an alginate scaffold. To compare the regenerative potential of moderately versus severely degenerated cells using 3 proanabolic stimulants. Injection of soluble cell signaling factors has potential to slow the progression of IVD degeneration. Although degenerative grade is ...
Wang Jinheng - - 2013
Human T‑cell leukemia virus type 1 (HTLV‑1), the first retrovirus to be identified, is the etiological agent of an aggressive clonal malignancy of mature CD4+ T lymphocytes known as adult T‑cell leukemia (ATL). The prognosis of ATL patients remains poor despite the availability of a number of clinical chemotherapy drugs. In ...
Carr Brian I - - 2013
To evaluate the growth-inhibitory properties of the potent multi-kinase antagonist Regorafenib (Fluoro-Sorafenib), which was synthesized as a more potent Sorafenib, a Raf inhibitor and to determine whether similar mechanisms were involved, human hepatoma cell lines were grown in the presence or absence of Regorafanib and examined for growth inhibition. Western ...
Manzanares Miguel Vicente - - 2013
A new study reveals that non-muscle myosin II plays a central role in the durotaxis of mesenchymal stem cells, with the two major isoforms, II-A and II-B, being cooperatively required for this cell movement, and serine phosphorylation of the II-A isoform playing a negative role.
Jin Lin - - 2012
In this study, a novel three-dimensional fluffy PPy conductive fibrous scaffold (3D-cFSs) was fabricated by electrospinning technique combined with situ surface polymerization. Chemical compositions, morphology were characterized by fourier transform infrared (FTIR) and scanning electron microscopy (SEM). The results showed that the average diameter of PPy coated PLLA fibers in ...
Subramanian Anuradha A Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, USA. - - 2013
The need for tissue-engineered constructs as replacement tissue continues to grow as the average age of the world's population increases. However, additional research is required before the efficient production of laboratory-created tissue can be realized. The multitude of parameters that affect cell growth and proliferation is particularly daunting considering that ...
Trosan Peter P Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech - - 2012
Limbal stem cells (LSC), which reside in the basal layer of the limbus, are thought to be responsible for corneal epithelial healing after injury. When the cornea is damaged, LSC start to proliferate, differentiate, and migrate to the site of injury. To characterize the signaling molecules ensuring communication between the ...
Van Vu Ba - - 2012
Upon infection, phytopathogenic fungi secrete an array of hydrolytic enzymes that can degrade components of the host epidermis, including waxes, the cuticle, and cell walls. Cellulases, which can hydrolyze crystalline cellulose in the plant cell wall, are among these hydrolytic enzymes. Here, we provide RNAi-based evidence to show that cellulases ...
Zhang Gao - - 2012
Considerable data support the idea that oncogene-induced senescence remains a barrier that needs to be overcome for malignant transformation of melanocytes. Human nevi stain positive for the senescence-associated β-galactosidase marker, suggesting that cells have lost their proliferative capacity. Most nevi harbor B-RAF or N-RAS mutations, implying that they are growth ...
Tian Pei Ying - - 2012
  To investigate the role of ghrelin in the gastric cancer cell line AGS and its probable mechanism.   Cell proliferation was detected by MTT assay after treated with ghrelin or des-acyl ghrelin. The expression of growth hormone secretagogue receptor 1a (GHS-R1a) and 1b (GHS-R1b) mRNA was detected using reverse ...
Xie You-Ke - - 2012
Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-2 inhibited ...
Peng Y - - 2012
Transcriptional positive coactivator 4 (PC4) is a multifunctional nuclear protein that has important roles in DNA transcription, replication, repair and heterochromatinization. However, the role of PC4 in cancer remains to be clarified. Several studies propose that PC4 may act as a putative tumor suppressor. Here, we demonstrate for the first ...
Zhao Wenxiu - - 2012
Abstract Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms ...
Proseus Timothy E - - 2012
Pectate (polygalacturonic acid) acts as a chelator to bind calcium and form cross-links that hold adjacent pectate polymers and thus plant cell walls together. When under tension from turgor pressure in the cell, the cross-links appear to distort and weaken. New pectate supplied by the cytoplasm is undistorted and removes ...
Yang Liu - - 2012
The purpose of this study was to investigate the impact of SAM- and SH3-domain containing 1 (SASH1) on the biological behavior of glioma cells, including its effects on cellular growth, proliferation, apoptosis, invasion, and metastasis, and thereby to provide an experimental basis for future therapeutic treatments. A pcDNA3.1-SASH1 eukaryotic expression ...
Chen Jian - - 2012
Glioblastoma multiforme is the most common primary malignant brain tumour, with a median survival of about one year. This poor prognosis is due to therapeutic resistance and tumour recurrence after surgical removal. Precisely how recurrence occurs is unknown. Using a genetically engineered mouse model of glioma, here we identify a ...
Wang Lin - - 2012
The successful use of transplanted cells and/or growth factors for tissue repair is limited by a significant cell loss and/or rapid growth factor diffusion soon after implantation. Highly porous alginate scaffolds formed with covalent crosslinking have been used to improve cell survival and growth factor release kinetics, but require open-wound ...
Driessens Gregory G Université Libre de Bruxelles, IRIBHM, Brussels B-1070, - - 2012
Recent studies using the isolation of a subpopulation of tumour cells followed by their transplantation into immunodeficient mice provide evidence that certain tumours, including squamous skin tumours, contain cells with high clonogenic potential that have been referred to as cancer stem cells (CSCs). Until now, CSC properties have only been ...
Schrader Stefan - - 2012
Purpose: Aim of this study was to evaluate the efficiency of human MRC-5 cells to act as a feeder layer for conjunctival epithelial cells in order to develop a complete xenobiotic-free culture system for the expansion of conjunctival epithelial progenitor cells for clinical applications. Methods: Human conjunctival epithelial cells were ...
Bongiorno Vagner Alexandre - - 2012
The cell cycle is controlled by numerous mechanisms that ensure correct cell division. If growth is not possible, cells may eventually promote autophagy, differentiation, or apoptosis. Microorganisms interrupt their growth and differentiate under general nutrient limitation. We analyzed the effects of phosphate limitation on growth and sporulation in the chytridiomycete ...
Nahata Alok - - 2012
PURPOSE: The study was designed to screen Sphaeranthus indicus, Ganoderma lucidum, and Urtica dioica for their anticancer activity against human cancer cell lines. Phytochemical screening of active extracts was also planned. METHODS: Petroleum ether, ethanolic, and aqueous extracts of S indicus Linn, G lucidum P Karst, and U dioica Linn ...
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