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Ma Xiaohong X The Robert H. Smith Faculty of Agriculture Food and Environment, The Robert H. Smith Institute for Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, 76100, Rehovot, - - 2014
Enhancing the membrane content of PtdInsP 2 , the already-recognized protein-regulating lipid, increased the osmotic water permeability of tobacco protoplasts, apparently by increasing the abundance of active aquaporins in their membranes. While phosphoinositides are implicated in cell volume changes and are known to regulate some ion channels, their modulation of ...
Elhadad Dana D The Infectious Diseases Research Laboratory, Sheba Medical Center, Tel-Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, - - 2014
Human infection with typhoidal Salmonella serovars causes a febrile systemic disease, termed enteric-fever. Here we establish that in response to a temperature equivalent to fever (39-42°C) Salmonella enterica serovars Typhi, Paratyphi A and Sendai significantly attenuate their motility, epithelial cell invasion and uptake by macrophages. Under these fever-like conditions, the ...
Martín-Villar E E 1] Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), Madrid, Spain [2] Randall Division of Cell & Molecular Biophysics, King's College London, London, - - 2014
Invadopodia are actin-rich cell membrane projections used by invasive cells to penetrate the basement membrane. Control of invadopodia stability is critical for efficient degradation of the extracellular matrix (ECM); however, the underlying molecular mechanisms remain poorly understood. Here, we uncover a new role for podoplanin, a transmembrane glycoprotein closely associated ...
Stower Matthew J MJ Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, - - 2014
The elaboration of anterior-posterior (A-P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epithelial cells, the anterior visceral endoderm (AVE). ...
Matsuo Isao I Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan - - 2014
During mouse embryogenesis, diffusible growth factors, i.e. fibroblast growth factors, Wnt, bone morphogenetic protein and Hedgehog family members, emanating from localized areas can travel through the extracellular space and reach their target cells to specify the cell fate and form tissue architectures in coordination. However, the mechanisms by which these ...
Koutrolos Michail - - 2014
Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effects in the peripheral immune organs, their role within the central nervous system during experimental autoimmune encephalomyelitis is unclear. Here, by combining a ...
Höfte Herman H INRA, Institut Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Saclay Plant Sciences, RD10, F-78026 Versailles, FranceAgroParisTech, Institut Jean-Pierre Bourgin, UMR 1318, ERL CNRS 3559, Saclay Plant Sciences, RD10, F-78026 Versailles, France - - 2014
Understanding how developmental and environmental signals control plant cell expansion requires an intimate knowledge of the architecture of the primary cell wall and the chemo-rheological processes that underlie cell wall relaxation. In this review I discuss recent findings that reveal a more prominent role than previously suspected for covalent bonds ...
Lange Alexander W AW Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, - - 2014
The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell proliferation and differentiation to control organ size and stem/progenitor cell behavior. Following airway injury, Yap was dynamically regulated in regenerating airway epithelial cells. To determine the role of Hippo signaling in the lung, the mammalian Hippo kinases, Mst1 and ...
Campos Manuel M Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, - - 2014
Cell size control is an intrinsic feature of the cell cycle. In bacteria, cell growth and division are thought to be coupled through a cell size threshold. Here, we provide direct experimental evidence disproving the critical size paradigm. Instead, we show through single-cell microscopy and modeling that the evolutionarily distant ...
Carvalho Cátia A CA Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, - - 2014
Mitotic spindle orientation is essential to control cell-fate specification and epithelial architecture [1]. The tumor suppressor Lgl localizes to the basolateral cortex of epithelial cells, where it acts together with Dlg and Scrib to organize apicobasal polarity [2]. Dlg and Scrib also control planar spindle orientation [3, 4], but how ...
Park Tae Joo TJ Dept. of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea. Electronic address: - - 2014
Planar cell polarity (PCP) signaling controls polarized behaviors in diverse tissues, including the collective cell movements of gastrulation and the planar polarized beating of motile cilia. A major question in PCP signaling concerns the mechanisms linking this signaling cascade with more general cytoskeletal elements to drive polarized behavior. Previously, we ...
Schlunk Frieder F Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany, - - 2014
Little is known about the pathophysiology of oral anticoagulation-associated intracerebral hemorrhage (OAC-ICH). We compared hematoma volume, number of terminal deoxynucleotidyl dUTP nick-end labeling (TUNEL)-positive cells (indicating cell death), MMP-9 levels, and perilesional edema formation between warfarin-treated mice and controls. Intracerebral hemorrhage was induced by an injection of collagenase into the ...
Zdychová J J Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. - - 2014
The abnormal proliferation of vascular smooth muscle cells (VSMC) is thought to play a role in the pathogenesis of atherosclerosis. Adipocytes produce several bioactive paracrine substances that can affect the growth and migration of VSMCs. Our study focuses on the direct effect of the bioactive substances in conditioned media (CM) ...
Oliveira Mariana B MB 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909 Caldas das Taipas. Guimarães, Portugal; ICVS/3B's PT Government Associated Laboratory, Braga/Guimarães, - - 2014
A new methodology is reported for the continuous, solvent- and oil-free production of photopolymerizable microparticles containing encapsulated human dermal fibroblasts. A precursor solution of cells in photo-reactive PEG-fibrinogen (PF) polymer was transported through a transparent injector exposed to light-irradiation before being atomized in a jet-in-air nozzle. Shear rheometry data indicated ...
Vergara Daniele D Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, - - 2014
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Genes which have been implicated in autosomal-recessive PD include PARK2 which codes for parkin, an E3 ubiquitin ligase that participates in a variety of cellular activities. In this study, we compared parkin-mutant primary fibroblasts, from a patient with parkin ...
Hickman Graham J GJ The John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, NG11 8NS, UK; Biomolecular & Materials Interface Research Group, Nottingham Trent University, Nottingham, NG11 8NS, - - 2014
Developing materials that can preferentially select defined cancer cell populations for biological characterization will greatly enhance our understanding of cancer cell growth, differentiation, and invasion. The transitional events between epithelial and mesenchymal phenotypes are particularly crucial, as primary tumors and secondary metastasis are generally epithelial in nature, whereas circulating mesenchymal ...
Lin Nan N Cell Sciences and Development, SAFC/Sigma-Aldrich, 2909 Laclede Ave., St. Louis, MO 63103, USA. Electronic address: - - 2014
We report the discovery and validation of a novel CHO cell engineering target for improving IgG expression, serpin peptidase inhibitor, clade B, member 1 (Serpinb1). Transcriptomic studies using microarrays revealed that Serpinb1 was up-regulated in cultures with IgG heavy and light chain transcription transiently repressed compared with cultures treated with ...
Kramer Illan J IJ Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Road, Toronto, Ontario, M5S 3G4, Canada; IBM Canada Research & Development Centre, 120 Bloor Street East, Toronto, Ontario, M4W 1B7, - - 2014
A colloidal quantum dot solar cell is fabricated by spray coating under ambient conditions. By developing a room temperature spray coating technique and implementing a fully automated process with near monolayer control-an approach termed as sprayLD-an electronic defect is eliminated resulting in solar cell performance and statistical distribution superior to ...
Gellert Manuela M Institut für Biochemie und Molekularbiologie, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität, Greifswald, - - 2014
The cytoskeleton, unlike the bony vertebrate skeleton or the exoskeleton of invertebrates, is a highly dynamic meshwork of protein filaments that spans through the cytosol of eukaryotic cells. Especially actin filaments and microtubuli do not only provide structure and points of attachments, but they also shape cells, they are the ...
Liu Yongmin Y Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, CCR, National Cancer Institute, NIH, Bldg. 37, Rm 4032, 37 Convent Drive, MSC-4255, Bethesda, MD, 20892-4255, USA, - - 2014
The nucleoside reverse transcriptase inhibitors (NRTIs), used for treatment of the human immunodeficiency virus-1, compromise mitochondria in cardiomyocytes and other host cells, limiting the clinical use of these drugs. To explore underlying mechanisms, we overexpressed PGC-1α, a master regulator of mitochondrial biogenesis, twofold in H9c2 rat cardiomyocyte cultures, hypothesizing that ...
de la Encarnación Ana A Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, - - 2014
Null mutations in GRN are associated with frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). However, the influence of progranulin (PGRN) deficiency in neurodegeneration is largely unknown. In neuroblastoma cells, silencing of GRN gene causes significantly reduced cell survival after serum withdrawal. The following observations suggest that alterations of the CDK4/6/retinoblastoma ...
Bonnemay Louise L Département de Chimie, Ecole Normale Supérieure - PSL Research University, UMR 8640 - CNRS - ENS - UPMC, Paris, - - 2014
Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the toolbox currently available in cell biology. Among the increasing ...
Kuilman Thomas T Chromosome Segregation Laboratory, Cancer Research UK London Research Institute Lincoln's Inn Fields Laboratories, London, UK t.kuilman@nki.nl - - 2014
The final event of the eukaryotic cell cycle is cytokinesis, when two new daughter cells are born. How the timing and execution of cytokinesis is controlled is poorly understood. Here, we show that downregulation of cyclin-dependent kinase (Cdk) activity, together with upregulation of its counteracting phosphatase Cdc14, controls each of ...
Mullineaux Conrad W CW School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, U.K.; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, - - 2014
Filamentous heterocyst-forming cyanobacteria are a beautiful example of prokaryotic multicellularity. The filaments can achieve simultaneous nitrogen fixation and oxygenic photosynthesis by co-operation between two cell types: the photosynthetic vegetative cells and the nitrogen-fixing heterocysts. The multicellular features exhibited by the system include differentiation of different cell types, metabolic interdependence and ...
Shi Runlin R Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, - - 2014
microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasis. On the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumor suppressors or oncogenes that target many cancer-related genes. This study aimed to investigate ...
Zhang Ting T Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu 610041, - - 2014
Recently, emerging evidence has shown that Stat3 controls tumor cell migration and invasion. However, the molecular mechanisms by which Stat3 controls the cell movement remain largely unknown. Embryonic gastrula progenitors display coordinated and orientated migration, called collective cell migration. Collective cell migration is the simultaneous movement of multiple cells and ...
Brandão Rodolfo R Departamento de Física, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, - - 2014
Viscous fingering formation in flat Hele-Shaw cells is a classical and widely studied fluid mechanical problem. Recently, instead of focusing on the development of the fingering instability, researchers have devised different strategies aiming to suppress its appearance. In this work, we study a protocol that intends to inhibit the occurrence ...
Cardoso Henrique J HJ CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Covilhã, - - 2014
Maintaining the delicate balance between cell survival and death is of the utmost importance for the proper development of germ cells and subsequent fertility. On the other hand, the fine regulation of tissue homeostasis by mechanisms that control cell fate is a factor that can prevent carcinogenesis. c-KIT is a ...
Cerchiari Alec A UC Berkeley - UCSF, Bioengineering , Genentech Hall-N544, 600 16TH Street , San Francisco, California, United States, 94158 , 6174178212 ; - - 2014
Patterned 3D cell culture models aim to more accurately represent the in vivo architecture of a tissue for the purposes of testing drugs, studying multicellular biology, or engineering functional tissues. However, patterning 3D multicellular structures within very soft hydrogels (< 500 Pa) that mimic the physicochemical environment of many tissues ...
Cannet Aude A *Signaling and cytoskeleton dynamics group, CRBM-CNRS, University of Montpellier, 1919 route de Mende, 34293 Montpellier - - 2014
The Rho GTPases RhoA and Rac1 function as master regulators of cytokinesis by controlling the actomyosin cytoskeleton. RhoA and Rac1 have to be respectively activated and inactivated at the division plane for cytokinesis to occur properly. The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP. However, the ...
Graml Veronika V The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Genetics Department, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK; Institute of Biochemistry, ETH Zürich, Schafmattstrasse 18, HPM G16.2, Zürich 8093, - - 2014
Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to simultaneously survey the fission yeast genome with respect to three key cellular processes: ...
Davis George E GE Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: - - 2014
Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.
Balcerowicz Martin M Botanical Institute and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, BioCenter, Zuelpicher Str. 47b, 50674 Cologne, Germany. Electronic address: - - 2014
Three recent publications identify the phytohormone auxin as a novel regulator of stomata development and distribution. We discuss how auxin signaling and polar auxin transport blend in with the established signaling network that controls cell division and differentiation within the stomatal cell lineage.
van Dop Maritza M Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The - - 2014
Multicellular plant development requires strict control of cell division orientation. A key unanswered question is how developmental regulators interact with the generic cell division machinery to trigger oriented divisions. We discuss the Arabidopsis embryo as a model for addressing this question. Recent progress in 3D imaging and computation now allows ...
Miyako Eijiro E Nanotube Research Center (NTRC), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba 305-8565 (Japan). - - 2014
A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that ...
Durdu Sevi S European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, - - 2014
Morphogenesis is the process whereby cell collectives are shaped into differentiated tissues and organs. The self-organizing nature of morphogenesis has been recently demonstrated by studies showing that stem cells in three-dimensional culture can generate complex organoids, such as mini-guts, optic-cups and even mini-brains. To achieve this, cell collectives must regulate ...
Hennig Stefan S Institut für Genetik, Technische Universität Dresden, 01062, Dresden, Germany, - - 2014
We report on a pheromone-based inter-species communication system, allowing for a controlled cell-cell communication between the two species Saccharomyces cerevisiae and Schizosaccharomyces pombe as a proof of principle. It exploits the mating response pathways of the two yeast species employing the pheromones, α- or P-factor, as signaling molecules. The authentic ...
Zeng Yuze - - 2014
We have designed and fabricated a nanocomposite substrate that can deliver spatially and temporally defined mechanical forces onto cells. This nanocomposite substrate comprises a 1.5 mm-thick near infrared (NIR) mechanoresponsive bottom layer of few-walled carbon nanotubes (FWCNTs) that are uniformly distributed and covalently connected to thermally responsive poly(N-isopropylacrylamide), and an ...
Lee Mihyun M Department of Chemistry, Center for Nature-inspired Technology in KINC, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of - - 2014
An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called "spheroform" inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet ...
Santra Tuhin Subhra TS Institute of Nano Engineering and Microsystems, National Tsing Hua University, Taiwan. - - 2014
We introduce a localized single-cell membrane nano-electroporation with controllable sequential molecular delivery by millisecond to nanosecond electrical pulses. An intense electrical field was generated by a pair of transparent indium tin oxide (ITO)-based nano-electrodes, which was confined to a narrow region of the single-cell membrane surface near the nano-electrode edges ...
Mentink Remco A RA Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the - - 2014
Members of the Wnt family of secreted signaling proteins are key regulators of cell migration and axon guidance. In the nematode C. elegans, the migration of the QR neuroblast descendants requires multiple Wnt ligands and receptors. We found that the migration of the QR descendants is divided into three sequential phases ...
Walia Ankit A Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, - - 2014
Many differentiated animal cells, and all higher plant cells, build interphase microtubule arrays of specific architectures without benefit of a central organizer, such as a centrosome, to control the location and geometry of microtubule nucleation. These acentrosomal arrays support essential cell functions such as morphogenesis [1, 2], but the mechanisms ...
Keire Paul A PA Benaroya Research Institute, United - - 2014
Leiomyosarcoma (LMS) is a mesenchymal cancer that occurs throughout the body. Although LMS is easily recognized histopathologically, the cause of the disease remains unknown. Versican, an extracellular matrix (ECM) proteoglycan, increases in LMS. Microarray analyses of 80 LMS and 24 leiomyomas show a significant elevated expression of versican in human ...
Su Boxing B Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, - - 2014
High Mobility Group N (HMGN) proteins are a family of chromatin structural proteins that specifically bind to nucleosome core particles. HMGN5 is a novel and characteristic member of the HMGN protein family. We have previously found that HMGN5 is upregulated in prostate cancer and its downregulation had been demonstrated to ...
Wang Ji - - 2014
Extracellular matrix (ECM) is a fibrous natural cell environment, possessing complicated micro-and nano- architectures, which provide extracellular signaling cues and influence cell behaviors. Mimicking this three dimensional micro environment in vitro is a challenge in developmental and disease biology. Here, suspended multilayer hierarchical nanofiber assemblies (diameter from microns to less ...
Aparicio Ricardo R Centro de Biología Molecular "Severo Ochoa" CSIC-UAM., c)NicolásCabrera1, 28049, Madrid, - - 2014
Background: The control of organ growth is critical for correct animal development. From flies to mammals the mechanisms regulating growth are conserved and the role of microRNAs in this process is emerging. The conserved miR-7 has been described to control several aspects of development. Results: Here, we have analyzed the ...
Kurup Samarchith P SP Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, - - 2014
During invasion of host cells by Trypanosoma cruzi, the parasite that causes Chagas disease, the elongated, flagellated trypomastigotes remodel into oval amastigotes with no external flagellum. The underlying mechanism of this remodeling and the fate of the flagellum are obscure. We discovered that T. cruzi trypomastigotes discard their flagella via an ...
Nijhout H Frederik HF Department of Biology, Duke University, Durham, NC 27708; email: - - 2014
The developmental mechanisms that control body size and the relative sizes of body parts are today best understood in insects. Size is controlled by the mechanisms that cause growth to stop when a size characteristic of the species has been achieved. This requires the mechanisms to assess size and respond ...
Zuo Yan Y University of Texas Health Science Center at Houston, Department of Integrative Biology and Pharmacology, 6431 Fannin St., Houston, Texas - - 2014
Animal cell division is a fundamental process that requires complex changes in cytoskeletal organization and function. Aberrant cell division often has disastrous consequences for the cell and can lead to cell senescence, neoplastic transformation or death. As important regulators of the actin cytoskeleton, Rho GTPases play major roles in regulating ...
Le Pabic Pierre P Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of - - 2014
Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical cadherin, Fat3, and its partner Dachsous-2 (Dchs2), control polarized cell-cell intercalation of cartilage precursors during craniofacial development. ...
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